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331 results on '"Nagai, E"'

5. Polymeric Materials for Microelectronic Applications

Author

HIROSHI ITO, SEIICHI TAGAWA, KAZUYUKI HORIE, Kazuyuki Horie, David Creed, Richard A. Cozad, Anselm C. Griffin, Charles E. Hoyle, Lixin Jin, Petharnan Subramanian, Sangya S. Varma, Krishnan Venkataram, Paul H. Kasai, Y. Aoki, H. Namba, F. Hosoi, S. Nagai, E. Reichmanis, M. E. Galvin, K. E. Uhrich, P.

Published
1995

18. Survival outcomes of 220 consecutive patients with three-staged thoracoscopic esophagectomy.

Author

Noshiro, H., Yoda, Y., Hiraki, M., Kono, H., Miyake, S., Uchiyama, A., and Nagai, E.

Subjects
TREATMENT of esophageal cancer, ESOPHAGECTOMY, CHEST endoscopic surgery, DISEASE relapse, ACQUISITION of data, RETROSPECTIVE studies
Abstract

Patients with thoracic esophageal cancer are often treated by minimally invasive esophagectomy. However, the long-term survival benefits of minimally invasive esophagectomy remain unclear. Two approaches are available for thoracoscopic surgery: one with the patient in the left lateral decubitus position ( LLDP), and the other with the patient in the prone position ( PP). We investigated the survival benefit of thoracoscopic esophagectomy according to the tumor stage and patient position during the thoracoscopic procedure. We reviewed the records of 220 consecutive patients with esophageal cancer treated from 1998 to 2012. In total, 146 and 74 patients were treated with thoracoscopic esophagectomy in the LLDP and PP, respectively. No patients were initially proposed to be candidates for esophagectomy by thoracotomy during the study period. Data collection was performed with a focus on survival and recurrent disease. Among all the 220 patients, the overall 5-year survival rates were 83.7%, 74.1%, 45.5%, 78.6%, 44.2%, 29.4% and 24.3% in the patients with pStage IA, IB, IIA, IIB, IIIA, IIIB and IIIC disease, respectively. Despite the greater number of dissected mediastinal lymph nodes in the PP procedure, there were no significant differences in the survival curves between the LLDP and PP procedures. The long-term results of thoracoscopic esophagectomy are comparable and acceptable. The PP procedure was not confirmed to offer a superior survival benefit to the LLDP procedure in this retrospective study. [ABSTRACT FROM AUTHOR]

Published
2016
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19. Genetic analysis of plant regeneration ability from cell suspension cultures of rice

Author

Tsukahara, M., Hirosawa, T., Nagai, E., Kato, H., Ikeda, R., and Maruyama, K.

Subjects
Genetic analysis, Cell culture, Cell suspensions, Plant regeneration
Abstract

This article 'Genetic analysis of plant regeneration ability from cell suspension cultures of rice' appeared in the International Rice Research Notes series, created by the International Rice Research Institute (IRRI) to expedite communication among scientists concerned with the development of improved technology for rice and rice-based systems. The series is a mechanism to help scientists keep each other informed of current rice research findings. The concise scientific notes are meant to encourage rice scientists to communicate with one another to obtain details on the research reported.

Published
1996
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20. Pleiotropic Effects of Mitiglinide in Type 2 Diabetes Mellitus

Author

Konya, H, primary, Miuchi, M, additional, Konishi, K, additional, Nagai, E, additional, Ueyama, T, additional, Kusunoki, Y, additional, Kimura, Y, additional, Nakamura, Y, additional, Ishikawa, T, additional, Inokuchi, C, additional, Katsuno, T, additional, Hamaguchi, T, additional, Miyagawa, J, additional, and Namba, M, additional

Published
2009
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28. Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival

Author

Ogura, Y, primary, Mizumoto, K, additional, Nagai, E, additional, Murakami, M, additional, Inadome, N, additional, Saimura, M, additional, Matsumoto, K, additional, Nakamura, T, additional, Maemondo, M, additional, Nukiwa, T, additional, and Tanaka, M, additional

Published
2005
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39. Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats.

Author

Takasuna, K, Hagiwara, T, Hirohashi, M, Kato, M, Nomura, M, Nagai, E, Yokoi, T, and Kamataki, T

Abstract

Purpose: SN-38, a metabolite of irinotecan hydrochloride (CPT-11), is considered to play a key role in the development of diarrhea as well as in the antitumor activity of CPT-11. We have previously found that the inhibition of beta-glucuronidase, which hydrolyzes detoxified SN-38 (SN-38 glucuronide) to reform SN-38, in the lumen by eliminating the intestinal microflora with antibiotics, markedly ameliorates the intestinal toxicity of CPT-11 in rats. In this study we compared the disposition of CPT-11 and its metabolites in rats treated with and without antibiotics.Methods: Rats were given drinking water containing 1 mg/ml penicillin and 2 mg/ml streptomycin from 5 days before the administration of CPT-11 (60 mg/kg i.v.) and throughout the experiment. CPT-11, SN-38 glucuronide and SN-38 concentrations in the blood, intestinal tissues and intestinal luminal contents were determined by HPLC.Results: Antibiotics had little or no effect on the pharmacokinetics of CPT-11, SN-38 glucuronide or SN-38 in the blood, or in the tissues or contents of the small intestine, which has less beta-glucuronidase activity in its luminal contents. In contrast, antibiotics markedly reduced the AUC1-24 h of SN-38 (by about 85%) in the large intestine tissue without changing that of CPT-11, and this was accompanied by a complete inhibition of the deconjugation of SN-38 glucuronide in the luminal contents.Conclusions: These results suggest that SN-38, which results from the hydrolysis of SN-38 glucuronide by beta-glucuronidase in the intestinal microflora, contributes considerably to the distribution of SN-38 in the large intestine tissue, and that inhibition of the beta-glucuronidase activity by antibiotics results in decreased accumulation of SN-38 in the large intestine. [ABSTRACT FROM AUTHOR]

Published
1998

50. Carcinoma of the ampulla of Vater synchronously associated with early gastric cancer—a report of two cases

Author

Yamashita, H., Higashijima, H., Fukushima, K., Nagai, E., Makino, I., Okamoto, S., Kuroki, S., Ichimiya, H., and Chijiiwa, K.

Abstract

We report two cases of carcinoma of the ampulla of Vater synchronously associated with early gastric cancers. The gastric lesions were diagnosed pre-operatively in one patient and at the time of examination of the resected specimen following pancreatoduodenectomy in the other. Specific problems in the diagnosis and management of these multiple primary carcinomas are discussed. Careful evaluation of the stomach prior to the surgical treatment for ampullary carcinoma is recommended.

Published
1995
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