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5. Most Survivors Are Glad to Have a VAD

Author

Stevenson, L.W., primary, Lindenfeld, J., additional, Grady, K., additional, Vader, J., additional, Givertz, M., additional, Naftel, D., additional, Baldwin, T., additional, Myers, S., additional, Kormos, R., additional, and Kirklin, J.K., additional

Published
2017
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6. Glad to Have a VAD Across Intermacs Profiles

Author

Pagani, F., primary, Kittleson, M., additional, Stewart, G., additional, DeVore, A., additional, Brinkley, M., additional, Myers, S., additional, Miller, M., additional, Naftel, D., additional, Teuteberg, J.J., additional, and Stevenson, L.W., additional

Published
2017
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7. The Duration of Inotropic Support and Survival After Left Ventricular Assist Device

Author

Grandin, E., primary, Mooney, D., additional, Kennedy, K., additional, Kiernan, M.S., additional, Kociol, R.D., additional, Teuteberg, J.J., additional, Pagani, F.D., additional, Gaffey, A.C., additional, Atluri, P., additional, Birati, E.Y., additional, Myers, S., additional, Naftel, D., additional, Oliveira, G., additional, Simpson, K.E., additional, Yeh, R.W., additional, Kirklin, J.K., additional, Kormos, R.L., additional, and Rame, J., additional

Published
2017
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9. The impact of flow PRA on outcome in pediatric heart recipients in modern era: An analysis of the Pediatric Heart Transplant Study database.

Author

the Pediatric Heart Transplant Study Investigators, Das, B. B., Pruitt, E., Kirklin, J. K., Naftel, D. C., Molina, K., Ravekes, W., Auerbach, S., Savage, A., Knox, L., and Hsu, D.

Subjects
HEART transplantation, TRANSPLANTATION of organs, tissues, etc. in children, GRAFT rejection, IMMUNOSUPPRESSION, HEALTH outcome assessment, MEDICAL databases, FLOW cytometry
Abstract

Abstract: Data from patients in the Pediatric Heart Transplant Study (PHTS) registry transplanted between 2010 and 2014 were analyzed to determine the association between HLA antibody (PRA) determined by SPA using Luminex or flow cytometry with a positive retrospective cross‐match and the post‐transplant outcomes of acute rejection and graft survival. A total of 1459 of 1596 (91%) recipients had a PRA reported pretransplant; 26% had a PRA > 20%. Patients with a PRA > 20% were more likely to have CHD, prior cardiac surgery, ECMO support at listing, and waited longer for transplantation than patients with a PRA <20%. Patients with higher PRA% determined by SPA were predictive of a positive retrospective cross‐match determined by flow cytometric method (P < .001). A PRA > 50% determined by SPA was independently associated with worse overall graft survival after first month of transplant in both unadjusted and adjusted for all other risk factors. In this large multicenter series of pediatric heart transplant recipients, an elevated PRA determined by SPA remains a significant risk factor in the modern era. [ABSTRACT FROM AUTHOR]

Published
2018
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20. The Influence of Race and Common Genetic Variations on Outcomes After Pediatric Heart Transplantation

Author

Green, D. J., Brooks, M. M., Burckart, G. J., Chinnock, R. E., Canter, C., Addonizio, L. J., Bernstein, D., Kirklin, J. K., Naftel, D. C., Girnita, D. M., Zeevi, A., and Webber, S. A.

Abstract

Significant racial disparity remains in the incidence of unfavorable outcomes following heart transplantation. We sought to determine which pediatric posttransplantation outcomes differ by race and whether these can be explained by recipient demographic, clinical, and genetic attributes. Data were collected for 80 black and 450 nonblack pediatric recipients transplanted at 1 of 6 centers between 1993 and 2008. Genotyping was performed for 20 candidate genes. Average follow‐up was 6.25 years. Unadjusted 5‐year rates for death (p = 0.001), graft loss (p = 0.015), acute rejection with severe hemodynamic compromise (p = 0.001), late rejection (p = 0.005), and late rejection with hemodynamic compromise (p = 0.004) were significantly higher among blacks compared with nonblacks. Black recipients were more likely to be older at the time of transplantation (p < 0.001), suffer from cardiomyopathy (p = 0.004), and have public insurance (p < 0.001), and were less likely to undergo induction therapy (p = 0.0039). In multivariate regression models adjusting for age, sex, cardiac diagnosis, insurance status, and genetic variations, black race remained a significant risk factor for all the above outcomes. These clinical and genetic variables explained only 8–19% of the excess risk observed for black recipients. We have confirmed racial differences in survival, graft loss, and several rejection outcomes following heart transplantation in children, which could not be fully explained by differences in recipient attributes. Significant racial differences persist in pediatric heart transplant outcomes and can only be partly explained by common genetic variations.

Published
2017
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26. 532: Genetic Polymorphisms Impact the Risk of Infection in Pediatric Heart Transplantation – A Multi-Center Study

Author

Girnita, D.M., primary, Brooks, M.M., additional, Webber, S.A., additional, Burckart, G.J., additional, Ferrell, R., additional, Girnita, A.L., additional, Chinnock, R., additional, Canter, C., additional, Addonizio, L., additional, Bernstein, D., additional, Kirklin, J.K., additional, Naftel, D., additional, and Zeevi, A., additional

Published
2009
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27. 26-OR: Impact of genetic polymorphisms on rejection with hemodynamic compromise – A multi-institutional study

Author

Girnita, D.M., primary, Webber, S.A., additional, Brooks, M.M., additional, Burckart, G.J., additional, Ferrell, R., additional, Chinnock, R., additional, Canter, C., additional, Addonizio, L., additional, Bernstein, D., additional, Kirklin, J.K., additional, Naftel, D., additional, Girnita, A.L., additional, and Zeevi, A., additional

Published
2008
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28. 314: Genotypic Variation and Phenotypic Characterization of Granzyme B Gene Polymorphisms

Author

Girnita, D.M., primary, Webber, S.A., additional, Ferrell, R., additional, Brooks, M.M., additional, DeCroo, S., additional, Burckart, G., additional, Zdanowicz, G., additional, Chinnock, R., additional, Canter, C., additional, Addonizio, L., additional, Bernstein, D., additional, Kirklin, J.K., additional, Naftel, D., additional, Smith, L., additional, Girnita, A.L., additional, and Zeevi, A., additional

Published
2008
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32. 40-OR: The combination high VEGF/high IL-6 and low IL-10 gene polymorphism impact the risk of acute rejection in pediatric heart transplantation – a multicenter study

Author

Girnita, D.M., primary, Brooks, M., additional, Webber, S., additional, Burckart, G., additional, Ferrell, R., additional, Zdanowicz, G., additional, Chinnock, R., additional, Canter, C., additional, Addonizio, L., additional, Bernstein, D., additional, Kirklin, J., additional, Naftel, D., additional, Girnita, A., additional, and Zeevi, A., additional

Published
2007
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