Search

Your search keyword '"Nadine Nguendjoung Fainguem"' showing total 2 results
Start Over Author "Nadine Nguendjoung Fainguem"
2 results on '"Nadine Nguendjoung Fainguem"'

1. Evaluation of Viral Suppression in Paediatric Populations: Implications for the Transition to Dolutegravir-Based Regimens in Cameroon: The CIPHER-ADOLA Study

Author

Joseph Fokam, Yagai Bouba, Rogers Awoh Ajeh, Dominik Tameza Guebiapsi, Suzane Essamba, Albert Franck Zeh Meka, Ebiama Lifanda, Rose Armelle Ada, Liman Yakouba, Nancy Barbara Mbengono, Audrey Raissa Dzaddi Djomo, Suzie Ndiang Tetang, Samuel Martin Sosso, Jocelyne Carmen Babodo, Olivia Francette Ndomo Ambomo, Edith Michele Temgoua, Caroline Medouane, Sabine Ndejo Atsinkou, Justin Leonel Mvogo, Roger Martin Onana, Jean de Dieu Anoubissi, Alice Ketchaji, Alex Durand Nka, Davy-Hyacinthe Anguechia Gouissi, Aude Christelle Ka’e, Nadine Nguendjoung Fainguem, Rachel Simo Kamgaing, Désiré Takou, Michel Carlos Tommo Tchouaket, Ezechiel Ngoufack Jagni Semengue, Marie Amougou Atsama, Julius Nwobegahay, Comfort Vuchas, Anna Nya Nsimen, Bertrand Eyoum Bille, Sandra kenmegne Gatchuessi, Francis Ndongo Ateba, Daniel Kesseng, Serge Clotaire Billong, Daniele Armenia, Maria Mercedes Santoro, Francesca Ceccherini-Silberstein, Paul Ndombo Koki, Hadja Cherif Hamsatou, Vittorio Colizzi, Alexis Ndjolo, Carlo-Federico Perno, and Anne-Cecile Zoung-Kanyi Bissek

Subjects
viral suppression, low-level viremia, children, adolescents, young adults, DTG-based regimen, Biology (General), QH301-705.5
Abstract

Mortality in children accounts for 15% of all AIDS-related deaths globally, with a higher burden among Cameroonian children (25%), likely driven by poor virological response. We sought to evaluate viral suppression (VS) and its determinants in a nationally representative paediatric and young adult population receiving antiretroviral therapy (ART). A cross-sectional and multicentric study was conducted among Cameroonian children (p < 0.001. VS was 85.1% on a DTG-based regimen versus 80.0% on efavirenz/nevirapine and 65.6% on lopinavir/ritonavir or atazanavir/ritonavir. VS was higher in females versus males (85.8% versus 78.2%, p < 0.001). The VS rate remained stable around 85% at 12 and 24 months but dropped to about 80% at 36 months after ART initiation, p < 0.009. Independent predictors of non-VS were younger age, longer ART duration (>36 months), backbone drug (non-TDF/3TC) and anchor drug (non-DTG based). In this Cameroonian paediatric population with varying levels of transition to DTG, overall VS remains below the 95% targets. Predictors of non-VS are younger age, non-TDF/3TC- and non-DTG-based regimens. Thus, efforts toward eliminating paediatric AIDS should prioritise the transition to a DTG-based regimen in this new ART era.

Published
2024
Full Text
View/download PDF

2. High concordance in SARSCoV- 2 detection between automated (Abbott m2000) and manual (DaAn gene) RT-PCR systems: The EDCTP PERFECT-Study in Cameroon

Author

Nadine Nguendjoung Fainguem, Joseph Fokam, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Désiré Takou, Joshua Ageboh Nkembi-leke, Claudia Alteri, Luna Colagrossi, Roméo Bouba Yagai, Collins Ambe Chenwi, Michel Carlos Tchouaket Tommo, Grace Angong Beloumou, Aude Christelle Ka’e, Sandrine Claire Ndjeyep Djupsa, Aissatou Abba, Laeticia Grace Heunko Yatchou, Krystel Nnomo Zam, Rachel Kamgaing, Samuel Martin Sosso, Lucien Mama, Nicaise Ndembi, Vittorio Colizzi, Carlo-Federico Perno, Giulia Cappelli, and Alexis Ndjolo

Subjects
Public Health, Environmental and Occupational Health
Abstract

Molecular diagnosis of COVID-19 is critical to the control of the pandemic, which is a major threat to global health. Several molecular tests have been validated by WHO, but would require operational evaluation in the field to ensure their interoperability in diagnosis. In order to ensure field interoperability in molecular assays for detection of SARS-CoV-2 RNA, we evaluated the diagnostic concordance of SARS-CoV-2 between an automated (Abbott) and a manual (DaAn gene) realtime PCR (rRT-PCR), two commonly used assays in Africa. A comparative study was conducted on 287 nasopharyngeal specimens at the Chantal BIYA International Reference Centre (CIRCB) in Yaounde-Cameroon. Samples were tested in parallel with Abbott and DaAn gene rRT-PCR, and performance characteristics were evaluated by Cohen’s coefficient and Spearman’s correlation. A total of 273 participants [median age (IQR) 36 (26-46) years] and 14 EQA specimens were included in the study. Positivity was on 30.0% (86/287) Abbott and 37.6% (108/287) DaAn gene. Overall agreement was 82.6% (237/287), with k=0.82 (95%CI: 0.777-0.863), indicating an excellent diagnostic agreement. The positive and negative agreement was 66.67% (72/108) and 92.18 % (165/179) respectively. Regarding Viral Load (VL), positive agreement was 100% for samples with high VLs (CT80%) between the Abbott and DaAn gene rRTPCR platforms supports interoperability between the two assays. Discordance occurs at low-VL, thus underscoring these tools as efficient weapons in limiting SARS-CoV-2 community transmission.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results