1. Translation, psychometric validation, and baseline results of the Patient-Reported Outcomes Measurement Information System (PROMIS) pediatric measures to assess health-related quality of life of patients with pediatric lymphoma in Malawi
- Author
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Helena Correia, Amy Amuquandoh, Atupele Mpasa, Nader El-Mallawany Kim, Olivia Manthalu, Peter Wasswa, Idah Mtete, Mary Chasela, Paula Ward, Katherine D. Westmoreland, Christopher C. Stanley, Steven S. Martin, Peter N. Kazembe, Mary Chikasema, Satish Gopal, Mary Mtunda, Ande Salima, Mercy Butia, Bryce B. Reeve, Salama Itimu, Stella Wachepa, and Toon van der Gronde
- Subjects
Male ,Malawi ,medicine.medical_specialty ,Patient-Reported Outcomes Measurement Information System ,Lymphoma ,Psychometrics ,Validity ,Context (language use) ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Surveys and Questionnaires ,Humans ,Medicine ,Patient Reported Outcome Measures ,030212 general & internal medicine ,Child ,Reliability (statistics) ,Depression (differential diagnoses) ,business.industry ,Hematology ,Translating ,Oncology ,030220 oncology & carcinogenesis ,Scale (social sciences) ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Physical therapy ,Anxiety ,Female ,medicine.symptom ,business - Abstract
INTRODUCTION Internationally validated tools to measure patient-reported health-related quality of life (HRQoL) are available, but efforts to translate and culturally validate such tools in sub-Saharan Africa (SSA) are scarce, particularly among children. METHODS The Patient-Reported Outcomes Measurement Information System 25-item pediatric short form (PROMIS-25) assesses six HRQoL domains-mobility, anxiety, depression, fatigue, peer relationships, and pain interference-by asking four questions per domain. There is a single-item pain intensity item. The PROMIS-25 was translated into Chichewa and validated for use in Malawi using mixed qualitative and quantitative methods. The validity and reliability of the PROMIS-25 was assessed. RESULTS Fifty-four pediatric patients with lymphoma completed the PROMIS-25. Structural validity was supported by interitem correlations and principal component analysis. Reliability of each scale was satisfactory (range alpha = 0.71-0.93). Known group validity testing showed that anemic children had worse fatigue (P = 0.016) and children with poor performance status had worse mobility (P
- Published
- 2018
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