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2. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schneider, Markus P., Schultheiss, Ulla T., Friedrich, Nele, and Nauck, Matthias

Published
2023
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5. Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease

Author

Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Paul, Rainer, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Cejka, Vladimir, Störk, Stefan, Nadal, Jennifer, Sitter, Thomas, Meiselbach, Heike, Busch, Martin, Schneider, Markus P., Saritas, Turgay, Schultheiss, Ulla T., Kotsis, Fruzsina, Wanner, Christoph, Eckardt, Kai-Uwe, and Krane, Vera

Published
2023
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7. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Alberth-Schmidt, Ulrike, Marschall, Sabine, Schefler, Eugenia, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Schmidt-Ott, Kai, Zeier, Martin, Sommerer, Claudia, Aykac, Mehtap, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Müller-Krebs, Sandra, Schultheiss, Ulla T., Friedrich, Nele, Nauck, Matthias, Nußhag, Christian, Reiser, Jochen, and Hayek, Salim S.

Published
2023
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8. Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort

Author

Winitzki, Doris, Zacharias, Helena U., Nadal, Jennifer, Baid-Agrawal, Seema, Schaeffner, Elke, Schmid, Matthias, Busch, Martin, Bergmann, Manuela M., Schultheiss, Ulla, Kotsis, Fruzsina, Stockmann, Helena, Meiselbach, Heike, Wolf, Gunter, Krane, Vera, Sommerer, Claudia, Eckardt, Kai-Uwe, Schneider, Markus P., Schlieper, Georg, Floege, Jürgen, and Saritas, Turgay

Published
2022
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10. Efficacy of Intensified Hygiene Measures with or without the Addition of Doxycycline in the Management of Filarial Lymphedema: A Randomized Double-Blind, Placebo-Controlled Clinical Trial in Tanzania.

Author

Ngenya, Abdallah, Klarmann-Schulz, Ute, John, Winfrida, Jebett Korir, Patricia, Kamugisha, Mathias, Nadal, Jennifer, Moshi, Dennis, Ricchiuto, Arcangelo, Oriyo, Ndekya, Sullivan, Sarah Mary, Laizer, Ruth, Horton, John, Demitrius, Max, Feichtner, Anja, Marandu, Thomas F., Mgaya, Yusuph, Kellings, Angelika, Kroidl, Inge, Ogondiek, John, and Kuehlwein, Janina M.

Published
2024
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11. Adherence to Hygiene Protocols and Doxycycline Therapy in Ameliorating Lymphatic Filariasis Morbidity in an Endemic Area Post-Interruption of Disease Transmission in Ghana.

Author

Batsa Debrah, Linda, Klarmann-Schulz, Ute, Osei-Mensah, Jubin, Kuehlwein, Janina M., Mubarik, Yusif, Nadal, Jennifer, Ayisi-Boateng, Nana Kwame, Ricchiuto, Arcangelo, Serwaa Opoku, Vera, Sullivan, Sarah M., Adu Mensah, Derrick, Horton, John, Rahamani, Abu Abudu, Budge, Philip J., Gbedema, Stephen, Jebett Korir, Patricia, Opoku, John, Pfarr, Kenneth, Boateng Kontoh, Derrick, and Kellings, Angelika

Published
2024
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12. Long-term outcomes of patients with IgA nephropathy in the German CKD cohort.

Author

Stamellou, Eleni, Nadal, Jennifer, Hendry, Bruce, Mercer, Alex, Seikrit, Claudia, Bechtel-Walz, Wibke, Schmid, Matthias, Moeller, Marcus J, Schiffer, Mario, Eckardt, Kai-Uwe, Kramann, Rafael, Floege, Jürgen, and investigators, the GCKD study

Subjects
*MAJOR adverse cardiovascular events, *RENAL replacement therapy, *PROPORTIONAL hazards models, *IGA glomerulonephritis, *CHRONIC kidney failure
Abstract

Background The importance of albuminuria as opposed to proteinuria in predicting kidney outcomes in primary immunoglobulin A nephropathy (IgAN) is not well established. Methods From 2010 to 2012, 421 patients with biopsy-proven IgAN have been enrolled into the German Chronic Kidney Disease (GCKD) cohort, a prospective observational cohort study (N  = 5217). Adjudicated endpoints include a composite kidney endpoint (CKE) consisting of eGFR decline >40%, eGFR <15 ml/min/1.73 m2 and initiation of kidney replacement therapy; the individual components of the CKE; and combined major adverse cardiac events (MACE), including non-fatal myocardial infarction, non-fatal stroke and all-cause mortality. The associations between the incidence of CKE and baseline factors, including demographics, laboratory values and comorbidities were analysed using the Cox proportional hazards regression model. Results The mean age of IgAN patients at baseline was 51.6 years (± 13.6) and 67% were male. The patient-reported duration of disease at baseline was 5.9 ± 8.1 years. Baseline median urine albumin:creatinine ratio (UACR) was 0.4 g/g [interquartile range (IQR) 0.1–0.8] and mean eGFR was 52.5 ± 22.4 ml/min/1.73 m2. Over a follow-up of 6.5 years, 64 (15.2%) patients experienced a >40% eGFR decline, 3 (0.7%) reached eGFR <15 ml/min/1.73 m2, 53 (12.6%) initiated kidney replacement therapy and 28% of the patients experienced the CKE. Albuminuria, with reference to <0.1 g/g, was most associated with CKE. Hazard ratios (HRs) at UACRs of 0.1–0.6 g/g, 0.6–1.4 g/g, 1.4–2.2 g/g and >2.2 g/g were 2.03 [95% confidence interval (CI) 1.02–4.05], 3.8 (95% CI 1.92–7.5), 5.64 (95% CI 2.58–12.33) and 5.02 (95% CI 2.29–11-03), respectively. Regarding MACE, the presence of diabetes [HR 2.53 (95% CI 1.11–5.78)] was the most strongly associated factor, whereas UACR and eGFR did not show significant associations. Conclusion In the GCKD IgAN subcohort, more than every fourth patient experienced a CKE event within 6.5 years. Our findings support the use of albuminuria as a surrogate to assess the risk of poor kidney outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Low adherence to CKD-specific dietary recommendations associates with impaired kidney function, dyslipidemia, and inflammation

Author

Kaesler, Nadine, Baid-Agrawal, Seema, Grams, Sabine, Nadal, Jennifer, Schmid, Matthias, Schneider, Markus P., and Eckardt, Kai-Uwe

Subjects
Chronic kidney failure -- Diet therapy -- Complications and side effects, Patient compliance -- Influence, Inflammation -- Risk factors, Dyslipidemias -- Risk factors, Food/cooking/nutrition, Health
Abstract

Background/Objectives A diet following chronic kidney disease (CKD)-specific recommendations is considered essential for optimal management of patients with CKD. However, data on the adherence to these recommendations and its implications for health-relevant biomarkers are lacking. The objectives were to estimate adherence to CKD-specific dietary recommendations, to identify characteristics and lifestyle variables associated with poor adherence, and to investigate the relationship of adherence with biomarkers. Methods In this cross-sectional analysis, average dietary intake was estimated in 3193 participants with moderately severe CKD enrolled into the observational multicenter German CKD study using a food frequency questionnaire. A CKD diet score was developed to assess adherence to CKD-specific dietary recommendations based on intake of sodium, potassium, fiber, protein, sugar, and cholesterol. The associations of dietary adherence with characteristics, lifestyle variables, and biomarker levels were determined. Results Logistic regression analysis revealed younger age, higher body mass index, male gender, lower educational attainment, various lifestyle variables (cigarette smoking, infrequent alcohol consumption, low physical activity), and lower estimated glomerular filtrate rate associated with lower adherence to dietary recommendations. Low adherence to dietary recommendations was further associated with dyslipidemia, higher uric acid, and C-reactive protein levels. Associations between low dietary adherence and biomarkers were mostly driven by low intake of fiber and potassium, and high intake of sugar and cholesterol. Conclusions This study revealed differential characteristics and biomarkers associated with lower adherence to CKD-specific dietary recommendations. Promotion of CKD-specific dietary recommendations may help to mitigate the adverse prognosis in CKD patients., Author(s): Nadine Kaesler [sup.1] , Seema Baid-Agrawal [sup.2] , Sabine Grams [sup.3] , Jennifer Nadal [sup.4] , Matthias Schmid [sup.4] , Markus P. Schneider [sup.5] [sup.6] , Kai-Uwe Eckardt [sup.5] [...]

Published
2021
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15. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schachtl-Riess, Johanna F., Kheirkhah, Azin, Grüneis, Rebecca, Di Maio, Silvia, Schoenherr, Sebastian, Streiter, Gertraud, Losso, Jamie Lee, Paulweber, Bernhard, Lamina, Claudia, and Coassin, Stefan

Published
2021
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18. Long-term outcomes of adults with FSGS in the German Chronic Kidney Disease cohort.

Author

Stamellou, Eleni, Nadal, Jennifer, Hendry, Bruce, Mercer, Alex, Bechtel-Walz, Wibke, Schiffer, Mario, Eckardt, Kai-Uwe, Kramann, Rafael, Moeller, Marcus J, Floege, Jürgen, and investigators, GCKD study

Subjects
*MAJOR adverse cardiovascular events, *PROPORTIONAL hazards models, *DISEASE risk factors, *CHRONIC kidney failure, *RENAL replacement therapy
Abstract

Background Focal segmental glomerulosclerosis (FSGS) can lead to kidney failure in adults. This study examines the progression of FSGS in the German Chronic Kidney Disease (GCKD) cohort. Methods The GCKD study (N  = 5217), a prospective cohort, included 159 patients with biopsy-confirmed FSGS recruited from 2010 to 2012. Baseline was defined as the first study visit. Adjudicated endpoints included a composite kidney endpoint (CKE), including an estimated glomerular filtration rate (eGFR) decrease >40%, eGFR <15 ml/min/1.73 m2 or initiation of kidney replacement therapy and combined major adverse cardiovascular events (MACE), including non-fatal myocardial infarction or stroke and all-cause mortality. Associations between baseline demographics, laboratory data, comorbidity and CKE and MACE were analysed using the Cox proportional hazards regression model. Results The mean age at baseline was 52.1 ± 13.6 years, with a disease duration of 4.72 years (quartile 1: 1; quartile 3: 6) before joining the study. The median urinary albumin:creatinine ratio (UACR) at baseline was 0.7 g/g (IQR 0.1;1.8), while mean eGFR was 55.8 ± 23 ml/min/1.73 m2. Based on clinical and pathological features, 69 (43.4%) patients were categorized as primary FSGS, 55 (34.6%) as secondary FSGS and 35 (22%) as indeterminate. Over a follow-up of 6.5 years, 44 patients reached the composite kidney endpoint and 16 individuals had at least one MACE. UACR ≥0.7 g/g was strongly associated with both the composite kidney endpoint {hazard ratio [HR] 5.27 [95% confidence interval (CI) 2.4–11.5]} and MACE [HR 3.37 (95% CI 1.05–10.82)] compared with <0.7 g/g, whereas a higher eGFR at baseline (per 10 ml/min) was protective for both endpoints [HR 0.8 (95% CI 0.68–0.95) and HR 0.63 (95% CI 0.46–0.88), respectively]. Patients with secondary FSGS experienced a greater rate of eGFR decline than patients with primary FSGS. Conclusions Lower eGFR and higher albuminuria are key risk factors for kidney disease progression and cardiovascular events in patients with FSGS. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, Nadal, Jennifer, Fazzini, Federica, Lamina, Claudia, Schultheiss, Ulla T., and Steinbrenner, Inga

Published
2020
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20. Association Between Dietary Patterns and Kidney Function in Patients With Chronic Kidney Disease: A Cross-Sectional Analysis of the German Chronic Kidney Disease Study

Author

Heindel, Judith, Baid-Agrawal, Seema, Rebholz, Casey M., Nadal, Jennifer, Schmid, Matthias, Schaeffner, Elke, Schneider, Markus P., Meiselbach, Heike, Kaesler, Nadine, Bergmann, Manuela, Ernst, Sabine, Krane, Vera, Eckardt, Kai-Uwe, Floege, Jürgen, Schlieper, Georg, and Saritas, Turgay

Published
2020
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23. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Krane, Vera, additional, Saritas, Turgay, additional, Busch, Martin, additional, Schultheiss, Ulla T., additional, Meiselbach, Heike, additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Floege, Jürgen, additional, Kronenberg, Florian, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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24. No evidence to support the impact of migration background on treatment response rates and cancer survival: a retrospective matched-pair analysis in Germany

Author

Rüdiger, Roman, Geiser, Franziska, Ritter, Manuel, Brossart, Peter, Keyver-Paik, Mignon-Denise, Faridi, Andree, Vatter, Hartmut, Bootz, Friedrich, Landsberg, Jennifer, Kalff, Jörg C., Herrlinger, Ulrich, Kristiansen, Glen, Pietsch, Torsten, Aretz, Stefan, Thomas, Daniel, Radbruch, Lukas, Kramer, Franz-Josef, Strassburg, Christian P., Gonzalez-Carmona, Maria, Skowasch, Dirk, Essler, Markus, Schmid, Matthias, Nadal, Jennifer, Ernstmann, Nicole, Sharma, Amit, Funke, Benjamin, and Schmidt-Wolf, Ingo G. H.

Published
2021
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25. Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease - Prospective data from the German Chronic Kidney Disease cohort

Author

Ruhe, Johannes, primary, Nadal, Jennifer, additional, Bärthlein, Barbara, additional, Meiselbach, Heike, additional, Schultheiss, Ulla T, additional, Kotsis, Fruzsina, additional, Stockmann, Helena, additional, Krane, Vera, additional, Sommerer, Claudia, additional, Löffler, Ivonne, additional, Saritas, Turgay, additional, Kielstein, Jan T, additional, Sitter, Thomas, additional, Schneider, Markus P, additional, Schmid, Matthias, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Wolf, Gunter, additional, and Busch, Martin, additional

Published
2023
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26. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Sommerer, Claudia, primary, Müller-Krebs, Sandra, additional, Nadal, Jennifer, additional, Schultheiss, Ulla T., additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Schmid, Matthias, additional, Nußhag, Christian, additional, Reiser, Jochen, additional, Eckardt, Kai-Uwe, additional, Zeier, Martin, additional, Hayek, Salim S., additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Kraska, Detlef, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Alberth-Schmidt, Ulrike, additional, Marschall, Sabine, additional, Schefler, Eugenia, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Schmidt-Ott, Kai, additional, Sommerer, Claudia, additional, Aykac, Mehtap, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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31. Differential prognostic utility of adiposity measures in chronic kidney disease

Author

Cejka, Vladimir, primary, Störk, Stefan, additional, Nadal, Jennifer, additional, Schmid, Matthias, additional, Sommerer, Claudia, additional, Sitter, Thomas, additional, Meiselbach, Heike, additional, Busch, Martin, additional, Schneider, Markus P., additional, Saritas, Turgay, additional, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Krane, Vera, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Zeier, Martin, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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34. Prenatal ultrasound in fetuses with polycystic kidney appearance — expanding the diagnostic algorithm.

Author

Simonini, Corinna, Fröschen, Eva-Maria, Nadal, Jennifer, Strizek, Brigitte, Berg, Christoph, Geipel, Annegret, and Gembruch, Ulrich

Subjects
AUTOSOMAL recessive polycystic kidney, POLYCYSTIC kidney disease, GONADAL dysgenesis, KIDNEY diseases, AMNIOTIC liquid, LAURENCE-Moon-Biedl syndrome
Abstract

Purpose: Report on the diagnosis of prenatally detected fetal kidneys with bilateral polycystic appearance in a single center between 1999 and 2020 with special focus on renal morphology and biometry, amniotic fluid and extrarenal findings and proposal for an diagnostic algorithm. Methods: Retrospective observational study including pregnancies with prenatally detected kidneys with bilateral polycystic appearance (n = 98). Cases and outcomes were compared according to prenatal findings with special focus on renal morphology, amount of amniotic fluid, and presence of extrarenal abnormalities. Results: Most frequent diagnoses were autosomal recessive polycystic kidney disease (ARPKD, 53.1%), Meckel–Gruber syndrome (MKS, 17.3%) and autosomal dominant polycystic kidney disease (ADPKD, 8.2%). Other diagnoses included: Joubert-, Jeune-, McKusick–Kaufman- and Bardet–Biedl syndrome, overgrowth syndromes, Mainzer–Saldino syndrome and renal tubular dysgenesis. Renal abnormalities most frequently observed were hyperechogenic parenchyma, kidney enlargement, changes of corticomedullary differentiation and cystic changes of various degree. Oligo- and anhydramnios were mainly seen in ARPKD, RTD and second-trimester MKS. Extrarenal findings included skeletal (35.7%) and cardiac (34.7%) abnormalities as well as abnormalities of the central nervous system (27.6%). Conclusion: Gestational age at manifestation, kidney size, visibility of cysts, echogenicity, amniotic fluid volume, and the presence of associated extrarenal malformations allow to differentiate between the most frequent underlying diseases presenting with bilateral polycystic kidneys on prenatal ultrasound by following a diagnostic algorithm. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Heart-Type Fatty Acid Binding Protein, Cardiovascular Outcomes, and Death: Findings From the German CKD Cohort Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Wanner, Christoph, additional, Krane, Vera, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Busch, Martin, additional, Sitter, Thomas, additional, Friedrich, Nele, additional, Stockmann, Helena, additional, Meiselbach, Heike, additional, Nauck, Matthias, additional, Kronenberg, Florian, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2022
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40. Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study.

Author

Steinbrenner, Inga, Sekula, Peggy, Kotsis, Fruzsina, Cube, Maja von, Cheng, Yurong, Nadal, Jennifer, Schmid, Matthias, Schneider, Markus P, Krane, Vera, Nauck, Matthias, Eckardt, Kai-Uwe, Schultheiss, Ulla T, and investigators, the GCKD

Subjects
CHRONIC kidney failure, KIDNEY physiology, CHRONICALLY ill, RENAL fibrosis, OSTEOPONTIN, KIDNEY failure
Abstract

Background Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated OPN's association with kidney markers and KF. Methods OPN was measured from baseline serum samples of German Chronic Kidney Disease study participants. Cross-sectional regression models for estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) as well as Cox regression models for all-cause mortality and KF were evaluated to estimate the OPN effect. Additionally, the predictive ability of OPN and time-dependent population-attributable fraction were evaluated. Results Over a median follow-up of 6.5 years, 471 KF events and 629 deaths occurred among 4950 CKD patients. One-unit higher log(OPN) was associated with 5.5 mL/min/1.73 m2 lower eGFR [95% confidence interval (95% CI) –6.4 to –4.6] and 1% change in OPN with 0.7% higher UACR (estimated effect 0.7, 95% CI 0.6–0.8). Moreover, higher OPN levels were associated with a higher risk of KF [hazard ratio (HR) 1.4, 95% CI 1.2–1.7] and all-cause mortality (HR 1.5, 95% CI 1.3–1.8). After 6 years, 31% of the KF events could be attributed to higher OPN levels (95% CI 3%–56%). Conclusions In this study, higher OPN levels were associated with kidney function markers worsening and a higher risk for adverse outcomes. A larger proportion of KF could be attributed to higher OPN levels, warranting further research on OPN with regards to its role in CKD progression and possible treatment options. [ABSTRACT FROM AUTHOR]

Published
2023
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43. The Cardiovascular Literature-Based Risk Algorithm (CALIBRA): Predicting Cardiovascular Events in Patients With Non-Dialysis Dependent Chronic Kidney Disease

Author

Neri, Luca, primary, Lonati, Caterina, additional, Titapiccolo, Jasmine Ion, additional, Nadal, Jennifer, additional, Meiselbach, Heike, additional, Schmid, Matthias, additional, Baerthlein, Barbara, additional, Tschulena, Ulrich, additional, Schneider, Markus P., additional, Schultheiss, Ulla T., additional, Barbieri, Carlo, additional, Moore, Christoph, additional, Steppan, Sonia, additional, Eckardt, Kai-Uwe, additional, Stuard, Stefano, additional, and Bellocchio, Francesco, additional

Published
2022
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45. Validation of a Novel Predictive Algorithm for Kidney Failure in Patients Suffering from Chronic Kidney Disease: The Prognostic Reasoning System for Chronic Kidney Disease (PROGRES-CKD)

Author

Bellocchio, Francesco, primary, Lonati, Caterina, additional, Ion Titapiccolo, Jasmine, additional, Nadal, Jennifer, additional, Meiselbach, Heike, additional, Schmid, Matthias, additional, Baerthlein, Barbara, additional, Tschulena, Ulrich, additional, Schneider, Markus, additional, Schultheiss, Ulla T., additional, Barbieri, Carlo, additional, Moore, Christoph, additional, Steppan, Sonja, additional, Eckardt, Kai-Uwe, additional, Stuard, Stefano, additional, and Neri, Luca, additional

Published
2021
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46. Urine Metabolite Levels, Adverse Kidney Outcomes, and Mortality in CKD Patients: A Metabolome-wide Association Study

Author

Steinbrenner, Inga, primary, Schultheiss, Ulla T., additional, Kotsis, Fruzsina, additional, Schlosser, Pascal, additional, Stockmann, Helena, additional, Mohney, Robert P., additional, Schmid, Matthias, additional, Oefner, Peter J., additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Sekula, Peggy, additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla T., additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, and Nadal, Jennifer, additional

Published
2021
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49. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Schachtl-Riess, Johanna F., primary, Kheirkhah, Azin, additional, Grüneis, Rebecca, additional, Di Maio, Silvia, additional, Schoenherr, Sebastian, additional, Streiter, Gertraud, additional, Losso, Jamie Lee, additional, Paulweber, Bernhard, additional, Eckardt, Kai-Uwe, additional, Köttgen, Anna, additional, Lamina, Claudia, additional, Kronenberg, Florian, additional, Coassin, Stefan, additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, Gronwald, Wolfram, additional, Schmid, Matthias, additional, and Nadal, Jennifer, additional

Published
2021
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50. Short-term real-world outcomes following intravitreal brolucizumab for neovascular AMD: SHIFT study.

Author

Maria Bulirsch, Louisa, Saßmannshausen, Marlene, Nadal, Jennifer, Liegl, Raffael, Thiele, Sarah, and Holz, Frank G.

Abstract

Background Brolucizumab has recently been approved in Europe as a novel treatment for patients with neovascular age-related macular degeneration (nAMD). We report on early experiences with real-world outcomes of switch to brolucizumab therapy in previously anti-vascular endothelial growth factor (anti-VEGF)- treated patients. Methods Patients with recalcitrant nAMD were switched to brolucizumab therapy. Functional and structural parameters 4 weeks after first brolucizumab injection were evaluated including best-corrected visual acuity (BCVA (logMAR)), foveal centre point (FCP (µm)), central subfield retinal thickness (CSRT (µm)) and macular volume (mm2). Results Sixty-three eyes of 57 patients with nAMD (52.6% females) with a mean (±SD) age of 79.5±6.7 years were included. Mean change of BCVA was 0.03±0.14 logMAR (p=0.115). Significant reductions were recorded for FCP with a mean (±SD) change of -66.81±72.63 µm, -66.76±60.71 µm for CSRT and -0.27±0.24 mm2 for macular volume (all p<0.001). Intraocular inflammation was observed in seven eyes of seven patients, including one case of retinal vasculitis. Conclusions The results of the SHIFT study indicate that switch to brolucizumab may represent a treatment option in patients with nAMD poorly responsive to other anti-VEGF agents. Further long-term analyses appear prudent to assess efficacy and safety of brolucizumab in a routine clinical setting. [ABSTRACT FROM AUTHOR]

Published
2022
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