485 results on '"Nachira, Dania"'
Search Results
2. Survival Outcome After Surgery in Patients With Thymoma Distant Recurrence
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Chiappetta, Marco, Sassorossi, Carolina, Nachira, Dania, Lococo, Filippo, Meacci, Elisa, Ruffini, Enrico, Guerrera, Francesco, Lyberis, Paraskevas, Aprile, Vittorio, Lucchi, Marco, Ambrogi, Marcello Carlo, Bacchin, Diana, Dell’Amore, Andrea, Marino, Carlotta, Comacchio, Giovannimaria, Roca, Gabriella, Rea, Federico, and Margaritora, Stefano
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- 2024
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3. Surgeon experience influence lymphadenectomy during VATS lobectomy: National VATS database results
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Maurizio, Mancuso, Fausto, Pernazza, Majed, Refai, Franco, Stella, Desideria, Argnani, Giuseppe, Marulli, Angela, De Palma, Luigi, Bortolotti, Giovanna, Rizzardi, Piergiorgio, Solli, Giampiero, Dolci, Reinhold, Perkmann, Francesco, Zaraca, Roberto, Benvenuti Mauro, Diego, Gavezzoli, Roberto, Cherchi, Albino, Ferrari Paolo, Felice, Mucilli, Pierpaolo, Camplese, Giulio, Melloni, Federico, Mazza, Giorgio, Cavallesco, Pio, Maniscalco, Luca, Voltolini, Alessandro, Gonfiotti, Francesco, Sollitto, Pia, Ardò Nicoletta, Luca, Pariscenti Gian, Carlo, Risso, Corrado, Surrente, Camillo, Lopez, Andrea, Droghetti, Michele, Giovanardi, Cristiano, Breda, Fabio, Lo Giudice, Marco, Alloisio, Edoardo, Bottoni, Lorenzo, Spaggiari, Roberto, Gasparri, Massimo, Torre, Alessandro, Rinaldo, Mario, Nosotti, Davide, Tosi, Giampeiro, Negri, Alessandro, Bandiera, Alessandro, Baisi, Federico, Raveglia, Alessandro, Stefani, Pamela, Natali, Marco, Scarci, Emanuele, Pirondini, Carlo, Curcio, Dario, Amore, Ottavio, Rena, Samuele, Nicotra, Andrea, Dell' Amore, Alessandro, Bertani, Giorgia, Tancredi, Luca, Ampollini, Paolo, Carbognani, Francesco, Puma, Damiano, Vinci, Giuseppe, Cardillo, Francesco, Carleo, Nachira, Dania, Piero, Paladini, Marco, Ghisalberti, Roberto, Crisci, Duilio, Divisi, Diego, Fontana, Vittorio, Della Beffa, Angelo, Morelli, Francesco, Londero, Andrea, Imperatori, Nicola, Rotolo, Alberto, Andrea, Viti, Maurizio, Infante, Cristiano, Benato, Chiappetta, Marco, Sassorossi, Carolina, Lococo, Filippo, Curcio, Carlo, Crisci, Roberto, Sperduti, Isabella, Meacci, Elisa, and Margaritora, Stefano
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- 2024
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4. Impact of High-Grade Patterns in Early-Stage Lung Adenocarcinoma: A Multicentric Analysis
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Bertoglio, Pietro, Aprile, Vittorio, Ventura, Luigi, Cattoni, Maria, Nachira, Dania, Lococo, Filippo, and Perez, Maria Rodriguez
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Adenocarcinoma -- Prognosis -- Analysis ,Health - Abstract
Objective The presence of micropapillary and solid adenocarcinoma patterns leads to a worse survival and a significantly higher tendency to recur. This study aims to assess the impact of pT descriptor combined with the presence of high-grade components on long-term outcomes in early-stage lung adenocarcinomas. Methods We retrospectively collected data of consecutive resected pT1-T3N0 lung adenocarcinoma from nine European Thoracic Centers. All patients who underwent a radical resection with lymph-node dissection between 2014 and 2017 were included. Differences in Overall Survival (OS) and Disease-Free Survival (DFS) and possible prognostic factors associated with outcomes were evaluated also after performing a propensity score matching to compare tumors containing non-high-grade and high-grade patterns. Results Among 607 patients, the majority were male and received a lobectomy. At least one high-grade histological pattern was seen in 230 cases (37.9%), of which 169 solid and 75 micropapillary. T1a-b-c without high-grade pattern had a significant better prognosis compared to T1a-b-c with high-grade pattern (p = 0.020), but the latter had similar OS compared to T2a (p = 0.277). Concurrently, T1a-b-c without micropapillary or solid patterns had a significantly better DFS compared to those with high-grade patterns (p = 0.034), and it was similar to T2a (p = 0.839). Multivariable analysis confirms the role of T descriptor according to high-grade pattern both for OS (p = 0.024; HR 1.285 95% CI 1.033-1.599) and DFS (p = 0.003; HR 1.196, 95% CI 1.054-1.344, respectively). These results were confirmed after the propensity score matching analysis. Conclusions pT1 lung adenocarcinomas with a high-grade component have similar prognosis of pT2a tumors., Author(s): Pietro Bertoglio [sup.1], Vittorio Aprile [sup.2], Luigi Ventura [sup.3] [sup.4], Maria Cattoni [sup.5], Dania Nachira [sup.6], Filippo Lococo [sup.6], Maria Rodriguez Perez [sup.7], Francesco Guerrera [sup.8], Fabrizio Minervini [sup.9], [...]
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- 2022
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5. Role of Peripheral Blood Markers for Detecting Response and Predicting Prognosis in Patients with Non-small-cell Lung Cancer Undergoing Neoadjuvant Therapy and Surgery
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Lococo, Filippo, Chiappetta, Marco, Evangelista, Jessica, Sperduti, Isabella, Nachira, Dania, Porziella, Venanzio, and Congedo, Maria Teresa
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Medical research -- Health aspects ,Medicine, Experimental -- Health aspects ,Cancer -- Adjuvant treatment ,Neoadjuvant therapy -- Health aspects ,Lung cancer, Non-small cell -- Prognosis ,Surgery -- Health aspects ,Health - Abstract
Introduction To date, no validated predictors of response before neoadjuvant therapy (NAD) are currently available in locally advanced non-small-cell lung cancer (NSCLC). In this study, different peripheral blood markers were investigated before NAD (pre-NAD) and after NAD/before surgery (post-NAD) to evaluate their influence on the treatment outcomes. Methods Patients affected by locally advanced NSCLC (cT1-T4/N0-2/M0) who underwent NAD followed by surgery from January 1996 to December 2019 were considered for this retrospective analysis. The impact of peripheral blood markers on downstaging post-NAD and on overall survival (OS) was evaluated using multivariate logistic and Cox regression models. Time to event analysis was performed by means of Kaplan-Meier survival curves and Log Rank tests at 5 years from surgery. Results Two hundred and seventy-two consecutive patients were included. Most of the patients had Stage III NSCLC (83.5%). N2 disease was reported in 188 (69.1%) patients. Surgical resection was performed in patients with stable disease or downstaging post-NAD. Nodal downstaging was observed in 80% of clinical N2 (cN2) patients. The median follow-up of the total series was 74 months (range 6-302). Five-year OS in the overall population and in N2 population was 74.6% and 73.5%, respectively. The pre-surgery platelets level (PLT) (p = 0.019) and the variation (pre-NAD/post-NAD) of the neutrophil/lymphocyte ratio (p = 0.024) were identified as independent prognostic factors of OS. The preoperative PLT value (p value = 0.031) was confirmed as the only predictor of NAD response. Conclusions The clinical role of peripheral blood markers in locally advanced NSCLC needs to be further investigated. Based on these preliminary results, these factors may be used as auxiliary markers for the prediction of response to neoadjuvant treatment and as prognostic factors for stratification in multimodal approaches., Author(s): Filippo Lococo [sup.1] [sup.2], Marco Chiappetta [sup.1] [sup.2], Jessica Evangelista [sup.2], Isabella Sperduti [sup.3], Dania Nachira [sup.1] [sup.2], Venanzio Porziella [sup.1] [sup.2], Maria Teresa Congedo [sup.1] [sup.2], Emilio Bria [...]
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- 2022
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6. Effectiveness of autologous emulsified stromal vascular fraction tissue injection for the treatment of complex perianal fistulas in inflammatory bowel diseases patients: a pilot study.
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Potenza, Angelo Eugenio, Nachira, Dania, Sacchetti, Franco, Trivisonno, Angelo, Pugliese, Daniela, Boškoski, Ivo, Caudullo, Giuseppe, Minordi, Laura Maria, Larosa, Luigi, Caprino, Paola, Scaldaferri, Franco, Sofo, Luigi, and Porziella, Venanzio
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INFLAMMATORY bowel diseases , *CROHN'S disease , *MAGNETIC resonance imaging , *MESENCHYMAL stem cells , *ULCERATIVE colitis - Abstract
Complex fistulizing perianal disease is a disabling manifestation of inflammatory bowel disease (IBD), seriously compromising patients 'quality of life'. The success rate of available treatments is quite low, and nearly half of the patients will develop chronically active fistulas or experience fistula recurrence. Mesenchymal stem cell therapy has shown interesting results, but the complexity and the cost of production limit its widespread use. This study aims to report the results of the innovative use of autologous emulsified adipose-derived stromal vascular fraction tissue for treating complex fistulizing perianal disease. From March 2021 to March 2022, 10 patients underwent a two-step procedure: (1) examination under anaesthesia, with loose seton drainage and 4 weeks later and (2) curettage of the fistulous tract, internal fistula closure and an injection of autologous emulsified adipose-derived stromal vascular fraction tissue harvested from the subcutaneous layer of the patient's hip. Clinical and radiological (through magnetic resonance imaging) healing were assessed at 6 months. We included five patients affected by Crohn's disease, three by ulcerative colitis and two by indeterminate colitis. All patients were on concomitant biological therapy (50% on Infliximab). One patient required a re-treatment for a relapse and two different fistulas were separately treated in another one. Out of 12 total procedures performed, clinical healing was achieved in 10 cases (83%), while radiological healing in 6 patients (50%). No adverse events were recorded. Autologous emulsified adipose-derived stromal vascular fraction tissue can represent an effective, safe and cheap add-on therapy for patients with complex perianal fistulas in IBDs. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Uniportal Video-Assisted Thoracoscopic Anatomic Lung Resection after Neoadjuvant Chemotherapy for Lung Cancer: A Case-Matched Analysis †.
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Andolfi, Marco, Meacci, Elisa, Salati, Michele, Xiumè, Francesco, Roncon, Alberto, Guiducci, Gian Marco, Tiberi, Michela, Nanto, Anna Chiara, Nachira, Dania, Nocera, Adriana, Calabrese, Giuseppe, Congedo, Maria Teresa, Inchingolo, Riccardo, Margaritora, Stefano, and Refai, Majed
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TREATMENT of lung tumors ,VIDEO-assisted thoracic surgery ,CARDIOPULMONARY system physiology ,PROBABILITY theory ,PATIENT readmissions ,TREATMENT effectiveness ,RETROSPECTIVE studies ,OPERATIVE surgery ,SURGICAL complications ,LUNG tumors ,COMBINED modality therapy ,COMPARATIVE studies ,LENGTH of stay in hospitals ,PERIOPERATIVE care ,TIME - Abstract
Simple Summary: In cases of advanced lung cancer after neoadjuvant chemotherapy (nCT), the role of uniportal video-assisted thoracoscopic surgery (U-VATS) is still questionable, with concerns about safety, technical feasibility, and oncological completeness. The aim of this retrospective study was to assess the impact of nCT on patients who had undergone U-VATS anatomic lung resections for lung cancer. We compared the short-term outcomes of 60 patients with case-matched counterparts (treated by surgery alone) selected by propensity score analysis, finding that U-VATS after nCT is a feasible approach with a similar rate of cardiopulmonary complications, length of stay, and readmission when compared with the control group. However, it is still a challenging surgery due to the great technical complexity, which is responsible for the higher incidence of conversion. Background: The advantages of video-assisted thoracic surgery (VATS) are well-recognized in several studies. However, in the cases of advanced lung cancer after neoadjuvant chemotherapy (nCT), the role of VATS is still questionable, with concerns about safety, technical feasibility, and oncological completeness. The aim of this study was to assess the impact of nCT on patients who had undergone uniportal VATS (U-VATS) anatomic lung resections for lung cancer, by comparing the short-term outcomes of patients after nCT with case-matched counterparts (treated by surgery alone). Methods: We performed a retrospective, comparative study enrolling 927 patients (nCT: 60; non-nCT:867) who underwent U-VATS anatomic lung resections from 2014 to 2020 in two centers. Data were collected in a shared database with standardized variables' definition. Propensity score matching using 15 baseline preoperative patients' characteristics was performed in order to minimize selection-confounding factors between the two groups, which then were directly compared in terms of perioperative outcomes. Results: After propensity score matching, two groups of 60 patients had been defined. The nCT-group had a higher conversion rate compared to the control group (13.3% vs. 0%, p = 0.003) without an increase in operation time or cardiopulmonary complications. In addition, no differences between the two groups were recorded in terms of prolonged air leaks, length of stay, and readmission. Conclusions: U-VATS after nCT is a feasible approach, showing a similar rate of cardiopulmonary complications and length of stay when compared with the control group. However, it remains a challenging surgery due to its great technical complexity as well as the clinical status of the patients. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Uniportal Video-Assisted Thoracoscopic Surgery Completion Lobectomy Long after Wedge Resection or Segmentectomy in the Same Lobe: A Bicenter Study
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Meacci, Elisa, primary, Refai, Majed, additional, Nachira, Dania, additional, Salati, Michele, additional, Kuzmych, Khrystyna, additional, Tabacco, Diomira, additional, Zanfrini, Edoardo, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Congedo, Maria Teresa, additional, Chiappetta, Marco, additional, Petracca-Ciavarella, Leonardo, additional, Sassorossi, Carolina, additional, Andolfi, Marco, additional, Xiumè, Francesco, additional, Tiberi, Michela, additional, Guiducci, Gian Marco, additional, Vita, Maria Letizia, additional, Roncon, Alberto, additional, Nanto, Anna Chiara, additional, and Margaritora, Stefano, additional
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- 2024
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9. Letter to the Editor Regarding “Predictors of Compensatory Sweating Following Video-Assisted Thoracoscopic Sympathectomy in Primary Palmar Hyperhidrosis”
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Nachira, Dania, primary, Napolitano, Antonio Giulio, additional, Nocera, Adriana, additional, Congedo, Maria Teresa, additional, Meacci, Elisa, additional, Punzo, Giovanni, additional, and Margaritora, Stefano, additional
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- 2024
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10. The International Thymic Malignancy Interest Group Classification of Thymoma Recurrence: Survival Analysis and Perspectives
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Chiappetta, Marco, Lococo, Filippo, Zanfrini, Edoardo, Moroni, Rossana, Aprile, Vittorio, Guerrera, Francesco, Nachira, Dania, Congedo, Maria Teresa, Ambrogi, Marcello Carlo, Korasidis, Stylianos, Lucchi, Marco, Filosso, Pier Luigi, Ruffini, Enrico, Sperduti, Isabella, Meacci, Elisa, and Margaritora, Stefano
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- 2021
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11. The Efficacy of Continuous Serratus Anterior and Erector Spinae Plane Blocks vs Intercostal Nerve Block in Uniportal-Vats Surgery: A Propensity-Matched Prospective Trial
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Nachira, Dania, primary, Punzo, Giovanni, additional, Calabrese, Giuseppe, additional, Sessa, Flaminio, additional, Congedo, Maria Teresa, additional, Beccia, Giovanna, additional, Aceto, Paola, additional, Kuzmych, Khrystyna, additional, Cambise, Chiara, additional, Sassorossi, Carolina, additional, Nocera, Adriana, additional, Senatore, Alessia, additional, Vita, Maria Letizia, additional, Meacci, Elisa, additional, Sollazzi, Liliana, additional, and Margaritora, Stefano, additional
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- 2024
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12. Are the Efficacy and Safety of Chest Tubes in Uniportal Video-Assisted Thoracic Surgery Related to the Level of Intercostal Space Insertion or to the Drain Type? A Prospective Multicenter Study
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Nachira, Dania, primary, Bertoglio, Pietro, additional, Ismail, Mahmoud, additional, Napolitano, Antonio Giulio, additional, Calabrese, Giuseppe, additional, Kuzmych, Khrystyna, additional, Congedo, Maria Teresa, additional, Sassorossi, Carolina, additional, Meacci, Elisa, additional, Petracca Ciavarella, Leonardo, additional, Chiappetta, Marco, additional, Lococo, Filippo, additional, Solli, Piergiorgio, additional, and Margaritora, Stefano, additional
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- 2024
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13. The Role of Human Papilloma Virus (HPV) in Primary Lung Cancer Development: State of the Art and Future Perspectives
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Nachira, Dania, primary, Congedo, Maria Teresa, additional, D’Argento, Ettore, additional, Meacci, Elisa, additional, Evangelista, Jessica, additional, Sassorossi, Carolina, additional, Calabrese, Giuseppe, additional, Nocera, Adriana, additional, Kuzmych, Khrystyna, additional, Santangelo, Rosaria, additional, Rindi, Guido, additional, and Margaritora, Stefano, additional
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- 2024
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14. Successful Therapy of Esophageal Fistulas by Endoscopic Injection of Emulsified Adipose Tissue Stromal Vascular Fraction
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Nachira, Dania, Trivisonno, Angelo, Costamagna, Guido, Toietta, Gabriele, Margaritora, Stefano, Pontecorvi, Valerio, Punzo, Giovanni, Porziella, Venanzio, and Boškoski, Ivo
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- 2021
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15. Effect of Lymph Node Dissection on the Prognosis of Thymic Carcinomas and Thymic Neuroendocrine Tumors
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Wang, Zi-Ming, Li, Feng, Liu, Xin-Ying, Nachira, Dania, Badakhshi, Harun, Rückert, Jens-C, and Ismail, Mahmoud
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- 2021
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16. Cardiophrenic lymph nodes in advanced ovarian cancer
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Agusti, Nuria, primary, Bonaldo, Giulio, additional, Kahn, Ryan M, additional, Rosati, Andrea, additional, Nachira, Dania, additional, Pan, Teresa L, additional, Mburu, Anisa, additional, Kochiashvili, Gvantsa, additional, Paredes, Pilar, additional, Hsu, Heng-Cheng, additional, Davies-Oliveira, Jennifer, additional, and Ramirez, Pedro T, additional
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- 2023
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17. Unsolved Issues in Thymic Epithelial Tumour Stage Classification: The Role of Tumour Dimension
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Sassorossi, Carolina, primary, Bertoglio, Pietro, additional, Lococo, Filippo, additional, Santoro, Gloria, additional, Meacci, Elisa, additional, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Brandolini, Jury, additional, Petroncini, Matteo, additional, Nocera, Adriana, additional, Charles-Davies, Diepriye, additional, Solli, Piergiorgio, additional, Margaritora, Stefano, additional, and Chiappetta, Marco, additional
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- 2023
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18. ASO Author Reflections: Minimally Invasive Secondary Cytoreductive Surgery for Ovarian Cancer Lymph Node Recurrence: Shaping Treatment with All Arrows in our Quiver
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Loverro, Matteo, Ergasti, Raffaella, Conte, Carmine, Gallitelli, Vitalba, Nachira, Dania, Scaglione, Giulia, Fagotti, Anna, Scambia, Giovanni, and Gallotta, Valerio
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- 2022
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19. Cardiophrenic lymph nodes in advanced ovarian cancer.
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Agusti, Nuria, Bonaldo, Giulio, Kahn, Ryan M., Rosati, Andrea, Nachira, Dania, Pan, Teresa L., Mburu, Anisa, Kochiashvili, Gvantsa, Paredes, Pilar, Heng-Cheng Hsu, Davies-Oliveira, Jennifer, and Ramirez, Pedro T.
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- 2024
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20. Regenerative medicine approaches for the management of respiratory tract fistulas
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Trivisonno, Angelo, Nachira, Dania, Boškoski, Ivo, Porziella, Venanzio, Di Rocco, Giuliana, Baldari, Silvia, and Toietta, Gabriele
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- 2020
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21. Fast-Tracking Patients Through the Diagnostic and Therapeutic Pathways of Intrathoracic Conditions: The Role of Uniportal Video-Assisted Thoracic Surgery
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Ismail, Mahmoud, Swierzy, Marc, Nachira, Dania, and Rückert, Jens C.
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- 2017
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22. Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy
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Meacci, Elisa, primary, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Ibrahim, Mohsen, additional, Pariscenti, Gianluca, additional, Petrella, Francesco, additional, Casiraghi, Monica, additional, De Stefani, Alessandro, additional, del Regno, Laura del, additional, Peris, Ketty, additional, Triumbari, Elizabeth Katherine Anna, additional, Schinzari, Giovanni, additional, Rossi, Ernesto, additional, Petracca-Ciavarella, Leonardo, additional, Vita, Maria Letizia, additional, Chiappetta, Marco, additional, Siciliani, Alessandra, additional, Peritore, Valentina, additional, Manitto, Mattia, additional, Morelli, Lucia, additional, Zanfrini, Edoardo, additional, Tabacco, Diomira, additional, Calabrese, Giuseppe, additional, Bardoni, Claudia, additional, Evangelista, Jessica, additional, Spaggiari, Lorenzo, additional, and Margaritora, Stefano, additional
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- 2023
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23. Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study
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Sassorossi, Carolina, primary, Congedo, Maria Teresa, additional, Nachira, Dania, additional, Tabacco, Diomira, additional, Chiappetta, Marco, additional, Evangelista, Jessica, additional, di Gioia, Adele, additional, Di Resta, Velia, additional, Sorino, Claudio, additional, Mondoni, Michele, additional, Leoncini, Fausto, additional, Calabrese, Giuseppe, additional, Napolitano, Antonio Giulio, additional, Nocera, Adriana, additional, Lococo, Achille, additional, Margaritora, Stefano, additional, and Lococo, Filippo, additional
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- 2023
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24. Surgical Resection of Pulmonary Metastases from Melanoma in Oligometastatic Patients: Results from a Multicentric Study in the Era of Immunoncology and Targeted Therapy
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Meacci, Elisa, Nachira, Dania, Congedo, Maria Teresa, Ibrahim, M., Pariscenti, G., Petrella, F., Casiraghi, M., De Stefani, A., del Regno, L., Peris, Ketty, Triumbari, E. K. A., Schinzari, Giovanni, Rossi, E., Petracca-Ciavarella, L., Vita, Maria Letizia, Chiappetta, M., Siciliani, A., Peritore, V., Manitto, M., Morelli, L., Zanfrini, E., Tabacco, Diomira, Calabrese, Giuseppe, Bardoni, C., Evangelista, Jessica, Spaggiari, L., Margaritora, Stefano, Meacci E. (ORCID:0000-0001-8424-3816), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Peris K. (ORCID:0000-0002-5237-0463), Schinzari G. (ORCID:0000-0001-6105-7252), Vita M. L., Tabacco D., Calabrese G., Evangelista J., Margaritora S. (ORCID:0000-0002-9796-760X), Meacci, Elisa, Nachira, Dania, Congedo, Maria Teresa, Ibrahim, M., Pariscenti, G., Petrella, F., Casiraghi, M., De Stefani, A., del Regno, L., Peris, Ketty, Triumbari, E. K. A., Schinzari, Giovanni, Rossi, E., Petracca-Ciavarella, L., Vita, Maria Letizia, Chiappetta, M., Siciliani, A., Peritore, V., Manitto, M., Morelli, L., Zanfrini, E., Tabacco, Diomira, Calabrese, Giuseppe, Bardoni, C., Evangelista, Jessica, Spaggiari, L., Margaritora, Stefano, Meacci E. (ORCID:0000-0001-8424-3816), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Peris K. (ORCID:0000-0002-5237-0463), Schinzari G. (ORCID:0000-0001-6105-7252), Vita M. L., Tabacco D., Calabrese G., Evangelista J., and Margaritora S. (ORCID:0000-0002-9796-760X)
- Abstract
In the last decade, the emergence of effective systemic therapies (ESTs) in the form of both targeted and immuno-based therapies has revolutionized the treatment of patients with advanced stage III and stage IV melanoma. Even though lungs represent the most frequent site of melanoma metastases, only limited data are available on the role of surgery in isolated pulmonary metastases from malignant melanoma (PmMM) in the era of ESTs. The aim of this study is to describe the outcomes of patients who underwent metastasectomy of PmMM in the era of ESTs, in order to identify prognostic factors affecting survival and to provide a framework for more informed patient selection of treatmeant with lung surgery in the future. Clinical data of 183 patients who underwent metastasectomy of PmMM between June 2008 and June 2021 were collected among four Italian Thoracic Centers. The main clinical, surgical and oncological variables reviewed were: sex, comorbidities, previous oncological history, melanoma histotypes and primary site, date of primary cancer surgical treatment, melanoma growth phase, Breslow thickness, mutation pattern disease, stage at diagnosis, metastatic sites, DFI (Disease Free Interval), characteristics of lung metastases (number, side, dimension, type of resection), adjuvant therapy after lung metastasectomy, site of recurrence, disease-free survival (DFS) and cancer-specific survival (CSS; defined as the time interval between the first melanoma resection or lung metastasectomy and death from cancer). All patients underwent surgical resection of the primary melanoma before lung metastasectomy. Twenty-six (14.2%) patients already had a synchronous lung metastasis at the time of primary melanoma diagnosis. A wedge resection was performed in 95.6% of cases to radically remove the pulmonary localizations, while an anatomical resection was necessary in the remaining cases. The incidence of major post-operative complications was null, while only 21 patients (11.5%) dev
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- 2023
25. Reducing Post-Operative Alveolo-Pleural Fistula by Applying PGA-Sheets (Neoveil) after Major Lung Resection: A Historical Case-Control Study
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Sassorossi, Carolina, Congedo, Maria Teresa, Nachira, Dania, Tabacco, Diomira, Chiappetta, M., Evangelista, Jessica, di Gioia, A., Di Resta, V., Sorino, C., Mondoni, M., Leoncini, F., Calabrese, Giuseppe, Napolitano, A. G., Nocera, Adriana, Lococo, A., Margaritora, Stefano, Lococo, Filippo, Sassorossi C., Congedo M. T., Nachira D. (ORCID:0000-0003-2937-9678), Tabacco D., Evangelista J., Calabrese G., Nocera A., Margaritora S. (ORCID:0000-0002-9796-760X), Lococo F. (ORCID:0000-0002-9383-5554), Sassorossi, Carolina, Congedo, Maria Teresa, Nachira, Dania, Tabacco, Diomira, Chiappetta, M., Evangelista, Jessica, di Gioia, A., Di Resta, V., Sorino, C., Mondoni, M., Leoncini, F., Calabrese, Giuseppe, Napolitano, A. G., Nocera, Adriana, Lococo, A., Margaritora, Stefano, Lococo, Filippo, Sassorossi C., Congedo M. T., Nachira D. (ORCID:0000-0003-2937-9678), Tabacco D., Evangelista J., Calabrese G., Nocera A., Margaritora S. (ORCID:0000-0002-9796-760X), and Lococo F. (ORCID:0000-0002-9383-5554)
- Abstract
Alveolo-pleural fistula remains a serious post-operative complication in lung cancer patients after surgery, which is associated with prolonged hospital stay and higher healthcare costs. The aim of this study is to evaluate the efficacy of a polyglycol acid (PGA)-sheet known as Neoveil in preventing post-operative air-leak in cases of detected intra-operative air-leak after lung resection. Between 11/2021 and 7/2022, a total of 329 non-small cell lung cancer (NSCLC) patients were surgically treated in two institutions. Major lung resections were performed in 251 cases. Among them, 44 patients with significant intra-operative air-leak at surgery were treated by reinforcing staple lines with Neoveil (study group). On the other hand, a historical group (selected by propensity score matched analysis) consisting of 44 lung cancer patients with significant intra-operative air leak treated by methods other than the application of sealant patches were considered as the control group. The presence of prolonged air-leak (primary endpoint), pleural drainage duration, hospital stay, and post-operative complication rates were evaluated. The results showed that prolonged air-leak (>5 days after surgery) was not observed in study group, while this event occurred in four patients (9.1%) in the control group. Additionally, a substantial reduction (despite not statistically significant) in the chest tube removal was noted in the study group with respect to the control group (3.5 vs. 4.5, p = 0.189). In addition, a significant decrease in hospital stay (4 vs. 6 days, p = 0.045) and a reduction in post-operative complications (2 vs. 10, p = 0.015) were observed in the study group when compared with the control group. Therefore, in cases associated with intra-operative air-leak after major lung resection, Neoveil was considered a safer and more effective aerostatic tool and represents a viable option during surgical procedures.
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- 2023
26. Pathological and clinical features of multiple cancers and lung adenocarcinoma: a multicentre study
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Bertoglio, Pietro, Ventura, Luigi, Aprile, Vittorio, Cattoni, Maria Angela, Nachira, Dania, Lococo, Filippo, Rodriguez Perez, Maria, Guerrera, Francesco, Minervini, Fabrizio, Gnetti, Letizia, Lenzini, Alessandra, Franzi, Francesca, Querzoli, Giulia, Rindi, Guido, Bellafiore, Salvatore, Femia, Federico, Bogina, Giuseppe Salvatore, Bacchin, Diana, Kestenholz, Peter, Ruffini, Enrico, Paci, Massimiliano, Margaritora, Stefano, Imperatori, Andrea Selenito, Lucchi, Marco, Ampollini, Luca, Terzi, Alberto Claudio, Nachira, Dania (ORCID:0000-0003-2937-9678), Lococo, Filippo (ORCID:0000-0002-9383-5554), Rindi, Guido (ORCID:0000-0003-2996-4404), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Bertoglio, Pietro, Ventura, Luigi, Aprile, Vittorio, Cattoni, Maria Angela, Nachira, Dania, Lococo, Filippo, Rodriguez Perez, Maria, Guerrera, Francesco, Minervini, Fabrizio, Gnetti, Letizia, Lenzini, Alessandra, Franzi, Francesca, Querzoli, Giulia, Rindi, Guido, Bellafiore, Salvatore, Femia, Federico, Bogina, Giuseppe Salvatore, Bacchin, Diana, Kestenholz, Peter, Ruffini, Enrico, Paci, Massimiliano, Margaritora, Stefano, Imperatori, Andrea Selenito, Lucchi, Marco, Ampollini, Luca, Terzi, Alberto Claudio, Nachira, Dania (ORCID:0000-0003-2937-9678), Lococo, Filippo (ORCID:0000-0002-9383-5554), Rindi, Guido (ORCID:0000-0003-2996-4404), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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OBJECTIVES: Lung cancer is increasingly diagnosed as a second cancer. Our goal was to analyse the characteristics and outcomes of early-stage resected lung adenocarcinomas in patients with previous cancers (PC) and correlations with adenocarcinoma subtypes.METHODS: We retrospectively reviewed data of patients radically operated on for stage I-II lung adenocarcinoma in 9 thoracic surgery departments between 2014 and 2017. Overall survival (OS) and time to disease relapse were evaluated between subgroups.RESULTS: We included 700 consecutive patients. PC were present in 260 (37.1%). Breast adenocarcinoma, lung cancer and prostate cancer were the most frequent (21.5%, 11.5% and 11.2%, respectively). No significant differences in OS were observed between the PC and non-PC groups (P = 0.378), with 31 and 75 deaths, respectively. Patients with PC had smaller tumours and were more likely to receive sublobar resection and to be operated on with a minimally invasive approach. Previous gastric cancer (P = 0.042) and synchronous PC (when diagnosed up to 6 months before lung adenocarcinoma; P = 0.044) were related, with a worse OS. Colon and breast adenocarcinomas and melanomas were significantly related to a lower incidence of high grade (solid or micropapillary, P = 0.0039, P = 0.005 and P = 0.028 respectively), whereas patients affected by a previous lymphoma had a higher incidence of a micropapillary pattern (P = 0.008).CONCLUSIONS: In patients with PC, we found smaller tumours more frequently treated with minimally invasive techniques and sublobar resection, probably due to a more careful follow-up. The impact on survival is not uniform and predictable; however, breast and colon cancers and melanoma showed a lower incidence of solid or micropapillary patterns whereas patients with lymphomas had a higher incidence of a micropapillary pattern.
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- 2022
27. Surgical Effectiveness of Uniportal-VATS Lobectomy Compared to Open Surgery in Early-Stage Lung Cancer
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Nachira, Dania, Congedo, Maria Teresa, Tabacco, Diomira, Sassorossi, Carolina, Calabrese, Giuseppe, Ismail, Mahmoud, Vita, Maria Letizia, Petracca Ciavarella, Leonardo, Margaritora, Stefano, Meacci, Elisa, Nachira, Dania (ORCID:0000-0003-2937-9678), Petracca-Ciavarella, Leonardo, Margaritora, Stefano (ORCID:0000-0002-9796-760X), Meacci, Elisa (ORCID:0000-0001-8424-3816), Nachira, Dania, Congedo, Maria Teresa, Tabacco, Diomira, Sassorossi, Carolina, Calabrese, Giuseppe, Ismail, Mahmoud, Vita, Maria Letizia, Petracca Ciavarella, Leonardo, Margaritora, Stefano, Meacci, Elisa, Nachira, Dania (ORCID:0000-0003-2937-9678), Petracca-Ciavarella, Leonardo, Margaritora, Stefano (ORCID:0000-0002-9796-760X), and Meacci, Elisa (ORCID:0000-0001-8424-3816)
- Abstract
BackgroundAlthough the feasibility and safety of Uniportal-Video-Assisted thoracic surgery (U-VATS) has been proven, its surgical effectiveness is still debated. The aim of this study is to assess the equivalence of the U-VATS approach compared with an open technique in terms of surgical (nodal-upstaging, complications, and post-operative results) and short-term survival outcomes. MethodsThe clinical data of patients undergoing lobectomy for NSCLC at our center, from January 2014 to December 2019, were analyzed retrospectively. All patients undergoing open or U-VATS lobectomy with lymphadenectomy for early-stage lung cancer (cT1-T3N0, stages IA-IIB) were included in the study. Only 230 patients satisfied the inclusion criteria. Group bias was reduced through 1:1 propensity score matching, which resulted in 46 patients in each group (open surgery and U-VATS). ResultsThe intra- and post-operative mortality were null in both groups. There was no difference in the post-operative complications (p: 1.00) between U-VATS and open lobectomy. There was also no recorded difference in the pathological nodal up-staging [11 (23.9%) after thoracotomy vs. 8 (17.4%) after U-VATS, p: 0.440). The chest tube duration was longer in the open group (p: 0.025), with a higher post-operative pain (p: 0.001). Additionally, the 3-year overall survival (OS) was 78% after U-VATS lobectomy vs. 74% after open lobectomy (p: 0.204), while 3-year disease-specific survival (DSS) was 97 vs. 89% (p: 0.371), respectively. The 3-year disease-free survival (DFS) was 62% in the U-VATS group and 66% in the thoracotomy group, respectively (p: 0.917). ConclusionsUniportal-VATS lobectomy for the treatment of early-stage lung cancer seems to be a safe and effective technique with similar surgical and short-term survival outcomes as open surgery, but with lower post-operative pain and shorter in-hospital stay.
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- 2022
28. Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
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Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Evangelista, Jessica, Falcoz, Pierre Emmanuel, Ruffini, Enrico, Van Schil, Paul, Scarci, Marco, Furàk, Jòzsef, Sollitto, Francesco, Guerrera, Francesco, Spaggiari, Lorenzo, Aigner, Clemen, Evangelia, Liverakou, Billè, Andrea, Moser, Bernhard, Thomas, Pascal Alexandre, Liberman, Moishe, Boubia, Souheil, Campisi, Alessio, Ampollini, Luca, Toker, Alper, Enyed, Attila, Voltolini, Luca, Van Raemdonck, Dirk, Margaritora, Stefano, Ests Thymic Working Group, Null, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Evangelista, Jessica, Falcoz, Pierre Emmanuel, Ruffini, Enrico, Van Schil, Paul, Scarci, Marco, Furàk, Jòzsef, Sollitto, Francesco, Guerrera, Francesco, Spaggiari, Lorenzo, Aigner, Clemen, Evangelia, Liverakou, Billè, Andrea, Moser, Bernhard, Thomas, Pascal Alexandre, Liberman, Moishe, Boubia, Souheil, Campisi, Alessio, Ampollini, Luca, Toker, Alper, Enyed, Attila, Voltolini, Luca, Van Raemdonck, Dirk, Margaritora, Stefano, Ests Thymic Working Group, Null, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II-III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG-TCs 78% vs. 50% in MG-TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients.
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- 2022
29. Is Surgery Worthwhile in Locally-advanced NSCLC Patients with Persistent N2-disease After Neoadjuvant Therapy?
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Lococo, Filippo, Chiappetta, Marco, Sassorossi, Corolina, Nachira, Dania, Evangelista, Jessica, Ciavarella, Leonardo Petracca, Congedo, Maria Teresa, Porziella, Venanzio, Boldrini, Luca, Larici, Anna Rita, Bria, Emilio, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), Porziella, Venanzio (ORCID:0000-0001-6000-3172), Larici, Annarila (ORCID:0000-0002-1882-6244), Bria, Emilio (ORCID:0000-0002-2333-704X), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Lococo, Filippo, Chiappetta, Marco, Sassorossi, Corolina, Nachira, Dania, Evangelista, Jessica, Ciavarella, Leonardo Petracca, Congedo, Maria Teresa, Porziella, Venanzio, Boldrini, Luca, Larici, Anna Rita, Bria, Emilio, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), Porziella, Venanzio (ORCID:0000-0001-6000-3172), Larici, Annarila (ORCID:0000-0002-1882-6244), Bria, Emilio (ORCID:0000-0002-2333-704X), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
- Abstract
Aims To explore the long-term survival in lung cancer patients with persistent mediastinal lymph nodal disease after neoadjuvant followed by surgical resection and to analyse prognostic factors in this specific subset of patients Background Surgery in non-small-cell lung cancer (NSCLC) patients with N2-disease after neoadjuvant therapy (NAD) has been debated and has been even more questioned with the advent of immunotherapy. Objective Describe long-term results of a multimodal approach in locally-advanced NSCLC patients with persistence of N2-disease and identify prognostic factors to target the strategy of care. Methods We retrospectively reviewed data of 121 consecutive Stage IIIA-N2 NSCLC patients who underwent NAD (chemoradiotherapy or chemotherapy) from 01/00 to 12/19, focusing our analysis on 37 patients with persistent N2s status after surgery. Kaplan-Meier and Cox regression analysis explored the associations between mortality and potential risk factors. Results The 5-year survival was 29.8%. Cox regression analysis suggested that young age (HR=0.98, C.I.95%: 0.97- 1.00; p=0.062), male sex (HR=3.8,C.I.95%:1.06-13.73;p=0.04), and adjuvant therapy (HR=6.81,C.I.95%:0.96-53.94;p=0.06) influenced long-term outcomes in these patients. Conclusion We herein observed suboptimal long-term results in this NSCLC patient subset, and, considering emerging results adopting immunotherapy following chemoradiotherapy, surgery should be carefully considered in very selected cases (young and clinically fit patients) and combined with adjuvant therapy after surgery.
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- 2022
30. Autologous Fat Grafting Restores Soft-tissue Contour Deformities after Vascular Anomaly: Widening the Horizons of Employment of Autologous Fat Grafting
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Trivisonno, Angelo, Nachira, Dania, Boškoski, Ivo, Calcagni, Filippo, Tringali, Andrea, Costamagna, Guido, Margaritora, Stefano, and Porziella, Venanzio
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- 2019
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31. Uniportal-VATS vs. open McKeown esophagectomy: Surgical and long-term oncological outcomes
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Nachira, Dania, primary, Congedo, Maria Teresa, additional, Calabrese, Giuseppe, additional, Tabacco, Diomira, additional, Petracca Ciavarella, Leonardo, additional, Meacci, Elisa, additional, Vita, Maria Letizia, additional, Punzo, Giovanni, additional, Lococo, Filippo, additional, Raveglia, Federico, additional, Chiappetta, Marco, additional, Porziella, Venanzio, additional, Guttadauro, Angelo, additional, Cioffi, Ugo, additional, and Margaritora, Stefano, additional
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- 2023
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32. Quantum surgery: the quantum mechanics insight beyond the uniportal video-assisted thoracic surgery (VATS) approach
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Bertolaccini, Luca, primary, Nachira, Dania, additional, Margaritora, Stefano, additional, and Spaggiari, Lorenzo, additional
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- 2023
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33. Uniportal-video-assisted thoracoscopic surgery (VATS) resection of multiple left thoracic neurofibromas: a case report
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Napolitano, Antonio Giulio, primary, Nachira, Dania, additional, Vita, Maria Letizia, additional, Leoni, Chiara, additional, and Margaritora, Stefano, additional
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- 2023
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34. Early nasal high-flow versus Venturi mask oxygen therapy after lung resection: a randomized trial
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Pennisi, Mariano Alberto, Bello, Giuseppe, Congedo, Maria Teresa, Montini, Luca, Nachira, Dania, Ferretti, Gian Maria, Meacci, Elisa, Gualtieri, Elisabetta, De Pascale, Gennaro, Grieco, Domenico Luca, Margaritora, Stefano, and Antonelli, Massimo
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- 2019
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35. Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis
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Congedo, Maria Teresa, primary, Nachira, Dania, additional, Pennisi, Mariano Alberto, additional, Chiappetta, Marco, additional, Calabrese, Giuseppe, additional, Bello, Giuseppe, additional, Parrilla, Claudio, additional, Franza, Laura, additional, Covino, Marcello, additional, Petracca Ciavarella, Leonardo, additional, Porziella, Venanzio, additional, Vita, Maria Letizia, additional, Lococo, Filippo, additional, Margaritora, Stefano, additional, and Meacci, Elisa, additional
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- 2022
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36. Prognostic factors for survival in advanced thymomas: The role of the number of involved structures
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Chiappetta, Marco, Aprile, Vittorio, Lococo, Filippo, Zanfrini, Edoardo, Nachira, Dania, Meacci, Elisa, Korasidis, Styliano, Ambrogi, Marcello, Lucchi, Marco, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), Meacci, Elisa (ORCID:0000-0001-8424-3816), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Chiappetta, Marco, Aprile, Vittorio, Lococo, Filippo, Zanfrini, Edoardo, Nachira, Dania, Meacci, Elisa, Korasidis, Styliano, Ambrogi, Marcello, Lucchi, Marco, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), Meacci, Elisa (ORCID:0000-0001-8424-3816), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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Background and Objectives The Masoka-Koga and tumor node metastases staging systems for thymoma are based on structures involved, but the prognostic role of the number of infiltrated/involved structures is still debated. We analyzed the prognostic role of involved structures and their combinations in locally advanced thymomas patients. Methods Data on 174 surgically treated locally advanced thymoma patients from 1/01/1990 to 31/12/2015 were reviewed. Clinical and pathological characteristic, involved structures, number of involved structures and different combinations were correlated to cancer specific survival (CSS) using Kaplan-Meier product-limit method. Results Five and 10-year CSS was 92% and 87%. Masaoka Stage 3 (p < 0.001), absence of pericardial involvement (p = 0.001), number of involved structures (p = 0.018), R0 (p < 0.001) and adjuvant radiotherapy (p = 0.008) were favorable prognostic CSS factors. A significant better prognosis was present in <= 2 involved structures vs >2 involved structures (5- and 10-year CSS: 95% and 93% vs. 80% and 51%). Multivariable analysis confirmed as independent prognostic factor R0 (p = 0.033, hazard ratio [HR]: 0.093, 95% confidence interval [CI] 0.010-0.827) and number of involved structures (p = 0.046, HR: 0.187, 95% CI: 0.036-0.968). In Masaoka Stage 3, patients with <= 2 involved structures had a significant better CSS than patients with >2 (10-year CSS: 98% vs. 73%, p = 0.008). Conclusions The number of involved structures and the concomitant involvement of the pericardium seems to be associated with a poor prognosis in surgically treated advanced thymoma patients.
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- 2021
37. Factors Affecting Long-Term Survival in Locally Advanced NSCLC Patients With Pathologic Complete Response After Induction Therapy Followed by Surgical Resection
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Sassorossi, Carolina, Lococo, Filippo, Pogliani, Luca, Tabacco, Diomira, Iaffaldano, Amedeo, Zanfrini, Edoardo, Nachira, Dania, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Sassorossi, Carolina, Lococo, Filippo, Pogliani, Luca, Tabacco, Diomira, Iaffaldano, Amedeo, Zanfrini, Edoardo, Nachira, Dania, Margaritora, Stefano, Lococo, Filippo (ORCID:0000-0002-9383-5554), Nachira, Dania (ORCID:0000-0003-2937-9678), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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N/A
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- 2021
38. Rib-oriented Thoracoscopic Sympathetic Surgery for Hyperhidrosis: Prospective Long-term Results and Quality of Life
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Nachira, Dania, Meacci, Elisa, Congedo, Maria Teresa, Petracca Ciavarella, Leonardo, Zanfrini, Edoardo, Iaffaldano, Amedeo Giuseppe, Vita, Maria Letizia, Chiappetta, Marco, Griffo, Raffaella, Lococo, Filippo, Margaritora, Stefano, Nachira, Dania (ORCID:0000-0003-2937-9678), Meacci, Elisa (ORCID:0000-0001-8424-3816), Congedo, Maria T, Petracca-Ciavarella, Leonardo, Iaffaldano, Amedeo, Vita, Maria L, Lococo, Filippo (ORCID:0000-0002-9383-5554), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Nachira, Dania, Meacci, Elisa, Congedo, Maria Teresa, Petracca Ciavarella, Leonardo, Zanfrini, Edoardo, Iaffaldano, Amedeo Giuseppe, Vita, Maria Letizia, Chiappetta, Marco, Griffo, Raffaella, Lococo, Filippo, Margaritora, Stefano, Nachira, Dania (ORCID:0000-0003-2937-9678), Meacci, Elisa (ORCID:0000-0001-8424-3816), Congedo, Maria T, Petracca-Ciavarella, Leonardo, Iaffaldano, Amedeo, Vita, Maria L, Lococo, Filippo (ORCID:0000-0002-9383-5554), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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BACKGROUND: The optimal thoracoscopic sympathetic surgery for primary palmar and/or axillary hyperhidrosis (PPAH) is still unclear because of lack of uniform technique and qualitative/quantitative scales for definition of results. The aims of this study were to compare long-term outcomes based on the surgical technique and the level of sympathetic trunk interruption by clipping and to assess postoperative compensatory sweating (CS), patients' satisfaction, and quality of life (QoL).MATERIALS AND METHODS: Between September 2009 and April 2016, 94 patients who underwent 2-stage bilateral thoracoscopic rib-oriented (R) sympathetic clipping were prospectively followed up through the administration of standardized preoperative and postoperative questionnaires.Thirty-four (36.2%) patients underwent single-port transaxillary access instead of the standard two 5-mm incisions. The level of sympathetic clipping for PPAH was R3+4(top and bottom); in patients who complained associated facial or plantar hyperhidrosis R2-bottom and R5-top were clipped, respectively. Seventy-five patients completed bilateral surgery.RESULTS: There were no significant differences between single-port and biportal video-assisted thoracoscopic surgery in terms of operative times and postoperative results. At a mean follow-up of 72 (SD: 26) months, CS was reported in 42 (56%) patients, severe only in 6 (8%). It was higher in the case of R2-bottom clipping (P=0.03). Thirty-one of 60 (51.6%) patients who had a plantar hyperhidrosis declared an improvement of feet sweating after surgery. Postoperative satisfaction was excellent (86.11% on a 0 to 100 scale) and 95.4% of patients declared an improvement in QoL, which was statistically significant in all evaluated parameters. These results were not related to the level of clipping.CONCLUSION: Thoracoscopic R3 to R4 clipping appears to be a safe and effective treatment for PPAH. Although postoperative CS was common and higher after R2-bottom clipping, this di
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- 2021
39. Claiming more evidence for a potentially complete and promising block in VATS surgery
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Punzo, Giovanni, Nachira, Dania, Sollazzi, Liliana, Nachira, Dania (ORCID:0000-0003-2937-9678), Sollazzi, Liliana (ORCID:0000-0002-2973-6236), Punzo, Giovanni, Nachira, Dania, Sollazzi, Liliana, Nachira, Dania (ORCID:0000-0003-2937-9678), and Sollazzi, Liliana (ORCID:0000-0002-2973-6236)
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Claiming more evidence for a potentially complete and promising block in VATS surgery
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- 2021
40. A Delphi Consensus report from the 'Prolonged Air Leak: A Survey' study group on prevention and management of postoperative air leaks after minimally invasive anatomical resections
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Zaraca, Francesco, Brunelli, Alessandro, Pipitone, Marco Damiano, Abdellateef, Amr, Abu Akar, Firas, Augustin, Florian, Batchelor, Tim, Bertani, Alessandro, Crisci, Roberto, D'Amico, Thomas, D'Journo, Xavier Benoit, Droghetti, Andrea, Fang, Wentao, Gonfiotti, Alessandro, Janík, Miroslav, Jiménez, Marcelo, Kirschbaum, Andreas, Kostic, Marko, Lazzaro, Richard, Lucchi, Marco, Marra, Alessandro, Murthy, Sudish, Ng, Calvin S H, Nachira, Dania, Pardolesi, Alessandro, Perkmann, Reinhold, Petersen, René Horsleben, Pischik, Vadim, Russo, Michele Dario, Opitz, Isabelle, et al, and University of Zurich
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10255 Clinic for Thoracic Surgery ,2740 Pulmonary and Respiratory Medicine ,610 Medicine & health ,2705 Cardiology and Cardiovascular Medicine ,2746 Surgery - Published
- 2022
41. Learning Curve of Robot-Assisted Thymectomy: Single Surgeon's 7-Year Experience
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Meacci, Elisa, primary, Nachira, Dania, additional, Congedo, Maria Teresa, additional, Petracca-Ciavarella, Leonardo, additional, Vita, Maria Letizia, additional, Porziella, Venanzio, additional, Chiappetta, Marco, additional, Lococo, Filippo, additional, Tabacco, Diomira, additional, Triumbari, Elizabeth Katherine Anna, additional, and Margaritora, Stefano, additional
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- 2022
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42. Impact of high-grade patterns in early-stage lung adenocarcinoma: a multicentric analysis
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Bertoglio, Pietro, primary, Aprile, Vittorio, additional, Ventura, Luigi, additional, Cattoni, Maria Angela, additional, Nachira, Dania, additional, Lococo, Filippo, additional, Perez, Maria Rodriguez, additional, Guerrera, Francesco, additional, Minervini, Fabrizio, additional, Querzoli, Giulia, additional, Bocchialini, Giovanni, additional, Bacchin, Diana, additional, Franzi, Francesca, additional, Rindi, Guido, additional, Bellafiore, Salvatore, additional, Femia, Federico, additional, Bogina, Giuseppe Salvatore, additional, Solli, Piergiorgio, additional, Kestenholz, Peter, additional, Ruffini, Enrico, additional, Paci, Massimiliano, additional, Margaritora, Stefano, additional, Imperatori, Andrea Selenito, additional, Lucchi, Marco, additional, Gnetti, Letizia, additional, and Terzi, Alberto Claudio, additional
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- 2022
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43. Is Topographic Classification Effective for Lymph Node Metastasis in Patients Affected by Non-Small Cell Lung Cancer?
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Chiappetta, Marco, Congedo, Maria Teresa, Nachira, Dania, Meacci, Elisa, and Margaritora, Stefano
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- 2017
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44. Incidence and management of post-lobectomy and pneumonectomy bronchopleural fistula
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Fuso, Leonello, Varone, Francesco, Nachira, Dania, Leli, Ilaria, Salimbene, Ivano, Congedo, Maria Teresa, Margaritora, Stefano, and Granone, Pierluigi
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Fistulas -- Research -- Care and treatment -- Complications and side effects ,Lobectomy -- Usage -- Health aspects ,Health - Abstract
Introduction Bronchopleural fistula is a rare but potentially fatal complication of pulmonary resections and proper management is essential for its resolution. In this study, we analyzed the incidence of fistula after pulmonary resection and reported data about endoscopic and conservative treatments of this complication. Methods From January 2003 to December 2013, 835 patients underwent anatomic lung resections: 786 (94.1 %) had a lobectomy and 49 (5.9 %) a pneumonectomy. Bronchopleural fistula was suspected by clinical signs and confirmed by endoscopic visualization. Results Eighteen patients (2.2 %) developed a bronchopleural fistula, 11 in lobectomy group (1.4 %) and 7 in pneumonectomy group (14.3 %). The fistula size ranged between Conclusion Endoscopic therapy, associated with a conservative treatment, is a safe and useful option in the management of the postoperative bronchopleural fistula., Author(s): Leonello Fuso[sup.1] [sup.3] , Francesco Varone[sup.1] , Dania Nachira[sup.2] , Ilaria Leli[sup.1] , Ivano Salimbene[sup.1] , Maria Teresa Congedo[sup.2] , Stefano Margaritora[sup.2] , Pierluigi Granone[sup.2] Author Affiliations: (1) Bronchoscopy [...]
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- 2016
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45. CT-guided fine-needle ago-biopsy of pulmonary nodules: predictive factors for diagnosis and pneumothorax occurrence
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Chiappetta, Marco, Rosella, Francesco, Dall’armi, Valentina, Pomes, Leda Marina, Petracca Ciavarella, Leonardo, Nachira, Dania, Pirronti, Tommaso, Margaritora, Stefano, and Granone, Pierluigi
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- 2016
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46. A Delphi Consensus report from the 'Prolonged Air Leak: A Survey' study group on prevention and management of postoperative air leaks after minimally invasive anatomical resections
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Zaraca, F., Brunelli, A., Pipitone, M. D., Abdellateef, A., Abu Akar, F., Augustin, F., Batchelor, T., Bertani, A., Crisci, R., D'Amico, T., D'Journo, X. B., Droghetti, A., Fang, W., Gonfiotti, A., Janík, M., Jimenez, M., Kirschbaum, A., Kostic, M., Lazzaro, R., Lucchi, M., Marra, Angelo Alessandro, Murthy, S., Ng, C. S. H., Nachira, Dania, Pardolesi, A., Perkmann, R., Petersen, R. H., Pischik, V., Russo, M. D., Opitz, I., Spaggiari, L., Ugalde, P. A., Vannucci, F., Veronesi, G., Bertolaccini, L., Marra A. (ORCID:0000-0001-8384-5081), Nachira D. (ORCID:0000-0003-2937-9678), Zaraca, F., Brunelli, A., Pipitone, M. D., Abdellateef, A., Abu Akar, F., Augustin, F., Batchelor, T., Bertani, A., Crisci, R., D'Amico, T., D'Journo, X. B., Droghetti, A., Fang, W., Gonfiotti, A., Janík, M., Jimenez, M., Kirschbaum, A., Kostic, M., Lazzaro, R., Lucchi, M., Marra, Angelo Alessandro, Murthy, S., Ng, C. S. H., Nachira, Dania, Pardolesi, A., Perkmann, R., Petersen, R. H., Pischik, V., Russo, M. D., Opitz, I., Spaggiari, L., Ugalde, P. A., Vannucci, F., Veronesi, G., Bertolaccini, L., Marra A. (ORCID:0000-0001-8384-5081), and Nachira D. (ORCID:0000-0003-2937-9678)
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OBJECTIVES: This study reports the results of an international expert consensus process evaluating the assessment of intraoperative air leaks (IAL) and treatment of postoperative prolonged air leaks (PAL) utilizing a Delphi process, with the aim of helping standardization and improving practice.METHODS: A panel of 45 questions was developed and submitted to an international working group of experts in minimally invasive lung cancer surgery. Modified Delphi methodology was used to review responses, including 3 rounds of voting. The consensus was defined a priori as >50% agreement among the experts. Clinical practice standards were graded as recommended or highly recommended if 50-74% or >75% of the experts reached an agreement, respectively.RESULTS: A total of 32 experts from 18 countries completed the questionnaires in all 3 rounds. Respondents agreed that PAL are defined as >5 days and that current risk models are rarely used. The consensus was reached in 33/45 issues (73.3%). IAL were classified as mild (<100 ml/min; 81%), moderate (100-400 ml/min; 71%) and severe (>400 ml/min; 74%). If mild IAL are detected, 68% do not treat; if moderate, consensus was not; if severe, 90% favoured treatment.CONCLUSIONS: This expert consensus working group reached an agreement on the majority of issues regarding the detection and management of IAL and PAL. In the absence of prospective, randomized evidence supporting most of these clinical decisions, this document may serve as a guideline to reduce practice variation.
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- 2022
47. Risk Factors Associated with Post-Operative Complications in Multidisciplinary Treatment of Descending Necrotizing Mediastinitis
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Congedo, Maria Teresa, Nachira, Dania, Pennisi, Mariano Alberto, Chiappetta, M., Calabrese, G., Bello, Giuseppe, Parrilla, Claudio, Franza, Laura, Covino, Marcello, Petracca Ciavarella, Leonardo, Porziella, Venanzio, Vita, Maria Letizia, Lococo, Filippo, Margaritora, Stefano, Meacci, Elisa, Congedo M. T., Nachira D. (ORCID:0000-0003-2937-9678), Pennisi M. A. (ORCID:0000-0001-8761-5144), Bello G. (ORCID:0000-0003-2648-7235), Parrilla C., Franza L., Covino M. (ORCID:0000-0002-6709-2531), Petracca Ciavarella L., Porziella V. (ORCID:0000-0001-6000-3172), Vita M. L., Lococo F. (ORCID:0000-0002-9383-5554), Margaritora S. (ORCID:0000-0002-9796-760X), Meacci E. (ORCID:0000-0001-8424-3816), Congedo, Maria Teresa, Nachira, Dania, Pennisi, Mariano Alberto, Chiappetta, M., Calabrese, G., Bello, Giuseppe, Parrilla, Claudio, Franza, Laura, Covino, Marcello, Petracca Ciavarella, Leonardo, Porziella, Venanzio, Vita, Maria Letizia, Lococo, Filippo, Margaritora, Stefano, Meacci, Elisa, Congedo M. T., Nachira D. (ORCID:0000-0003-2937-9678), Pennisi M. A. (ORCID:0000-0001-8761-5144), Bello G. (ORCID:0000-0003-2648-7235), Parrilla C., Franza L., Covino M. (ORCID:0000-0002-6709-2531), Petracca Ciavarella L., Porziella V. (ORCID:0000-0001-6000-3172), Vita M. L., Lococo F. (ORCID:0000-0002-9383-5554), Margaritora S. (ORCID:0000-0002-9796-760X), and Meacci E. (ORCID:0000-0001-8424-3816)
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Background: Descending necrotizing mediastinitis (DNM) is a severe, life-threatening complication of oropharyngeal infections with cervical necrotizing fasciitis. In this study, we aimed to identify any possible factors that correlate with favorable outcomes. Methods: We retrospectively analyzed our series of 18 patients who underwent surgical treatment for DNM from a cervical abscess. Gender, age, symptoms, etiopathogenesis, comorbidities, time to surgery from diagnosis, degree of diffusion, identified microorganisms, surgical procedure, days in the intensive care unit, need for tracheostomy, complications, and surgical outcomes were reviewed. Results: The main type of surgery was thoracotomy + cervicotomy in eight cases (50.0%), followed by cervicotomy +VATS in four (22.2%). Seven patients (38.9%) had two or more surgeries; a bilateral operation was necessary for four patients. Evaluating the risk factors associated with post-operative complications, age ≥ 60 years (p:0.031), cervicotomy alone as surgical approach (p = 0.040), and the bilateral approach (p = 0.048) resulted in significance in terms of the univariate analysis; age ≥ 60 years (p = 0.04) and cervical approach (p = 0.05) maintained their significance in terms of the multivariate analysis. Conclusions: The low mortality of our series emphasizes the importance of an extensive and immediate surgical drainage of both the neck and the mediastinum. Mediastinal drainage from cervicotomy seems to be a risk factor for post-operative complications. Minimally invasive surgery on the chest cavity, such as with Uniportal-VATS, could be a good approach above all in elderly patients and all those cases where bilateral access is required.
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- 2022
48. Learning Curve of Robot-Assisted Thymectomy: Single Surgeon's 7-Year Experience
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Meacci, Elisa, Nachira, Dania, Congedo, Maria Teresa, Petracca-Ciavarella, L., Vita, Maria Letizia, Porziella, Venanzio, Chiappetta, M., Lococo, Filippo, Tabacco, Diomira, Triumbari, E. K. A., Margaritora, Stefano, Meacci E. (ORCID:0000-0001-8424-3816), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Vita M. L., Porziella V. (ORCID:0000-0001-6000-3172), Lococo F. (ORCID:0000-0002-9383-5554), Tabacco D., Margaritora S. (ORCID:0000-0002-9796-760X), Meacci, Elisa, Nachira, Dania, Congedo, Maria Teresa, Petracca-Ciavarella, L., Vita, Maria Letizia, Porziella, Venanzio, Chiappetta, M., Lococo, Filippo, Tabacco, Diomira, Triumbari, E. K. A., Margaritora, Stefano, Meacci E. (ORCID:0000-0001-8424-3816), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Vita M. L., Porziella V. (ORCID:0000-0001-6000-3172), Lococo F. (ORCID:0000-0002-9383-5554), Tabacco D., and Margaritora S. (ORCID:0000-0002-9796-760X)
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Background: Robot-assisted thymectomy (RAT) has rapidly emerged as the preferred approach over open trans-sternal or video-assisted thoracoscopy for the surgical treatment of thymomas and non-thymomatous myasthenia gravis (MG). The aim of this study was to describe and discuss the learning curve (LC) of a single surgeon performing 113 consecutive RATs. Methods: A single-center retrospective analysis of prospectively collected clinical data was performed on all patients who had been operated on by the same surgeon in an RAT setting between October 2013 and February 2020. The cumulative sum (CUSUM) analysis of the operative time was used to define the completion of the learning curve (CLC) in RAT. The CLC was separately calculated for myasthenic patients, non-myasthenic patients, and docking time. Results: In myasthenic patients, the CLC cut-off was found in 19 patients. Considering the CLC cut-off of 19 patients, the mean operative time in phase 1 (first 19 cases) was 229.79 ± 93.40 min, while it was 167.35 ± 41.63 min in phase 2 (last 51 cases), (Formula presented.). In non-myasthenic patients, the CLC cut-off was found in 16 cases. The mean operative time in phase 1 (first 16 cases) was 277.44 ± 90.50 min, while it was 169.63 ± 61.10 min in phase 2 (last 27 cases), p = 0.016. The LC for docking time was reached at 46 cases, recording a significant reduction of time after the first phase (28.09 ± 5.37 min vs. 19.75 ± 5.51 min, (Formula presented.)). The intraoperative and 30-day mortality were null in all phases of the LC in both myasthenic and non-myasthenic patients. There were no differences between the two phases of the LC in terms of blood loss, duration of postoperative drainage, and postoperative stay in both myasthenic and non-myasthenic groups. However, significantly higher hospital readmission at 30 days post surgery was recorded for myasthenic patients operated on during the first phase of the LC (2 cases vs. 0, p = 0.02). Conclusions: According to our da
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- 2022
49. Prognostic role of standard uptake value according to pathologic features of lung adenocarcinoma
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Bertoglio, Pietro, Ventura, Luigi, Aprile, Vittorio, Cattoni, Maria Angela, Nachira, Dania, Lococo, Filippo, Rodriguez Perez, Maria, Guerrera, Francesco, Minervini, Fabrizio, Gnetti, Letizia, Bacchin, Diana, Franzi, Francesca, Querzoli, Giulia, Rindi, Guido, Bellafiore, Salvatore, Femia, Federico, Viti, Andrea, Kestenholz, Peter, Ruffini, Enrico, Paci, Massimiliano, Margaritora, Stefano, Imperatori, Andrea Selenito, Lucchi, Marco, Carbognani, Paolo, Terzi, Alberto Claudio, Lococo, Filippo (ORCID:0000-0002-9383-5554), Rindi, Guido (ORCID:0000-0003-2996-4404), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Bertoglio, Pietro, Ventura, Luigi, Aprile, Vittorio, Cattoni, Maria Angela, Nachira, Dania, Lococo, Filippo, Rodriguez Perez, Maria, Guerrera, Francesco, Minervini, Fabrizio, Gnetti, Letizia, Bacchin, Diana, Franzi, Francesca, Querzoli, Giulia, Rindi, Guido, Bellafiore, Salvatore, Femia, Federico, Viti, Andrea, Kestenholz, Peter, Ruffini, Enrico, Paci, Massimiliano, Margaritora, Stefano, Imperatori, Andrea Selenito, Lucchi, Marco, Carbognani, Paolo, Terzi, Alberto Claudio, Lococo, Filippo (ORCID:0000-0002-9383-5554), Rindi, Guido (ORCID:0000-0003-2996-4404), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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Objective: To evaluate the influence of lung adenocarcinoma second predominant pattern on the maximal standard uptake value (SUVmax) and its prognostic effect in different histologic groups. Methods: We retrospectively collected surgically resected pathologic stage I and II lung adenocarcinoma from nine European institutions. Only patients who underwent preoperative PET-CT and with available information regarding SUVmax of T (SUVmaxT) and N1 (SUVmaxN1) component were included. Results: We enrolled 344 patients with lung adenocarcinoma. SUVmaxT did not show any significant relation according to the second predominant pattern (p = 0.139); this relationship remained nonsignificant in patients with similar predominant pattern. SUVmaxT influenced the disease-free survival in the whole cohort (p = 0.002) and in low- and intermediate-grade predominant pattern groups (p = 0.040 and p = 0.008, respectively). In the high-grade predominant pattern cohort and in the pathologic N1 cases, SUVmaxT lost its prognostic power. SUVmaxN1 did not show any significant correlation with predominant and second predominant patterns and did not have any prognostic impact on DFS. Conclusions: SUVmaxT is influenced only by the adenocarcinoma predominant pattern, but not by second predominant pattern. Concurrently, in high-grade predominant pattern and pN1 group the prognostic power of SUVmaxT becomes nonsignificant.
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- 2022
50. Multimodal therapy for synchronous bone oligometastatic NSCLC: The role of surgery
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Congedo, Maria Teresa, Nachira, Dania, Bertolaccini, Luca, Chiappetta, Marco, Zanfrini, Edoardo, Meacci, Elisa, Vita, Maria Letizia, Lococo, Filippo, D'Argento, Ettore, Spaggiari, Lorenzo, Margaritora, Stefano, Meacci, Elisa (ORCID:0000-0001-8424-3816), Lococo, Filippo (ORCID:0000-0002-9383-5554), Margaritora, Stefano (ORCID:0000-0002-9796-760X), Congedo, Maria Teresa, Nachira, Dania, Bertolaccini, Luca, Chiappetta, Marco, Zanfrini, Edoardo, Meacci, Elisa, Vita, Maria Letizia, Lococo, Filippo, D'Argento, Ettore, Spaggiari, Lorenzo, Margaritora, Stefano, Meacci, Elisa (ORCID:0000-0001-8424-3816), Lococo, Filippo (ORCID:0000-0002-9383-5554), and Margaritora, Stefano (ORCID:0000-0002-9796-760X)
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Objectives The study aimed to assess the feasibility of radical surgical treatment for selected bone-oligometastatic non-small cell lung cancer (NSCLC) patients and to identify prognostic factors associated with survival. Materials and methods The clinical records of 27 patients with bone synchronous oligometastatic NSCLC were retrospectively analyzed. Results Thirteen (48.1%) bone metastases were treated by surgery and 14 (51.9%) by local radiotherapy. Eighteen (66.7%) patients underwent induction chemotherapy before lung surgery, and 3 (11.1%) concurrent radiotherapy. Pulmonary surgery was a major lung resection in 23 (85.2%) cases. Intraoperative and 30-days mortality was null. Only one major (ARDS) and 10 (37.04%) mild complications (like air leakage, arrhythmia, and mucus retention) were recorded. 1-year and 5-years OS from the diagnosis and 1-year, 3- years disease-free survival (DFS) were 96%, 38%, and 66%, 30%, respectively. After stepwise Cox regression analysis, local recurrence (p = 0.05) and metachronous metastases (p = 0.04) maintained their independent prognostic value as overall survival negative determinants. Nodal upstaging (p = 0.04) and nonsurgical treatment of bone lesion (p = 0.03) turned out to be independent risk factors for shorter DFS; the vertebral localization of bone metastases showed only a remarkable trend towards significance (p = 0.06) as a risk factor for a worse DFS. Conclusions In selected patients, surgical treatment of primary NSCLC and bone synchronous metastasis seems to be safe and feasible and rewarding survivals may be expected.
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- 2022
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