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4 results on '"Nabiha, Bashir"'

1. Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways

Author

Fawad Inayat, Imad Tariq, Nabiha Bashir, Fawad Ullah, and Hadiqa Aimen

Subjects
urothelial carcinoma, urological tumors, single nucleotide polymorphism (snp) sites, transitional cell carcinoma and next-generation sequencing (ngs), Medicine
Abstract

Urologic cancers, with bladder cancer as a pivotal subtype, pose substantial challenges to global health, necessitating a profound understanding of their molecular underpinnings. This article explores recent genomic research, with a focus on transitional cell carcinoma, the primary histological form of transitional cell carcinoma, aiming to elucidate the intricate molecular processes that underlie the onset and advancement of disease. Leveraging advanced genomic and transcriptomic analyses such as next-generation sequencing (NGS) and molecular subtyping techniques, this review delves into the diverse genetic and molecular subtypes inherent in bladder cancer. It emphasizes the critical role of molecular subtyping in guiding treatment decisions and refining patient stratification for precision medicine approaches. Furthermore, the review examines emerging diagnostic biomarkers such as methylation markers and single nucleotide polymorphism (SNP) sites, highlighting their potential in enabling early detection and targeted therapies. Their integration promises to enhance diagnostic accuracy and therapeutic monitoring in bladder cancer patients. Collaboration among multidisciplinary teams comprising clinicians, researchers, and bioinformaticians is paramount for unraveling the molecular complexities of urologic cancers and advancing personalized cancer care. This thorough review seeks to offer a detailed examination of the existing understanding on urologic oncology, offering valuable insights into the molecular intricacies of urothelial carcinoma and while also laying the groundwork for future research directions aimed at optimizing patient outcomes globally.

Published
2024
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2. Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients

Author

Mehreen Ishfaq, Nabiha Bashir, Syeda Kiran Riaz, Shumaila Manzoor, Jahangir Sarwar Khan, Yamin Bibi, Rokayya Sami, Amani H. Aljahani, Saif A. Alharthy, and Ramla Shahid

Subjects
Genetics, aerobic glycolysis, breast cancer, HK2, PFKM, PKM2, Warburg effect, Genetics (clinical)
Abstract

The reprogramming of energy metabolism is one of the hallmarks of cancer and is crucial for tumor progression. Altered aerobic glycolysis is a well-known characteristic of cancer cell metabolism. In the present study, the expression profiles of key metabolic genes (HK2, PFKM, and PKM2) were assessed in the breast cancer cohort of Pakistan using quantitative polymerase chain reaction (qPCR) and IHC. Expression patterns were correlated with molecular subtypes and clinical parameters in the patients. A significant upregulation of key glycolytic genes was observed in tumor samples in comparison to their adjacent controls (p < 0.0001). The expression of the studied glycolytic genes was significantly increased in late clinical stages, positive nodal involvement, and distant metastasis (p < 0.05). HK2 and PKM2 were found to be upregulated in luminal B, whereas PFKM was overexpressed in the luminal A subtype of breast cancer. The genes were positively correlated with the proliferation marker Ki67 (p < 0.001). Moreover, moderate positive linear correlations between HK2 and PKM2 (r = 0.476), HK2 and PFKM (r = 0.473), and PKM2 and PFKM (r = 0.501) were also observed (p < 0.01). These findings validate that the key regulatory genes in glycolysis can serve as potential biomarkers and/or molecular targets for breast cancer management. However, the clinical significance of these molecules needs to be further validated through in vitro and in vivo experiments.

Published
2022
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3. Expression of

Author

Mehreen, Ishfaq, Nabiha, Bashir, Syeda Kiran, Riaz, Shumaila, Manzoor, Jahangir Sarwar, Khan, Yamin, Bibi, Rokayya, Sami, Amani H, Aljahani, Saif A, Alharthy, and Ramla, Shahid

Subjects
Thyroid Hormones, Phosphofructokinase-1, Muscle Type, Hexokinase, Humans, Membrane Proteins, Breast Neoplasms, Female, Pakistan, Age of Onset, Neoplasm Metastasis, Carrier Proteins, Glycolysis
Abstract

The reprogramming of energy metabolism is one of the hallmarks of cancer and is crucial for tumor progression. Altered aerobic glycolysis is a well-known characteristic of cancer cell metabolism. In the present study, the expression profiles of key metabolic genes (

Published
2022

4. Association of reduced XRCC2 expression with lymph node metastasis in breast cancer tissues

Author

Syeda Sana, Nabiha Bashir, Mahmood Akhtar Kayani, and Ishrat Mahjabeen

Subjects
Oncology, Cancer Research, medicine.medical_specialty, Breast Neoplasms, Real-Time Polymerase Chain Reaction, Metastasis, XRCC2, Breast cancer, Internal medicine, Epidemiology, Gene expression, Genetics, medicine, Humans, Lymph node, Genetics (clinical), business.industry, medicine.disease, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Real-time polymerase chain reaction, Ki-67 Antigen, Lymphatic Metastasis, Cohort, Female, business
Abstract

The main purpose of this study was to evaluate the association between reduction in XRCC2 gene and involvement of lymph node metastasis in breast cancer. In first part of the study, meta-analysis of 14 published XRCC2 studies was performed to define the role of XRCC2 gene as diagnostic marker and in second part of the study XRCC2 gene expression was observed using real time PCR in study cohort of 100 females (50 breast cancer patients and 50 controls). A statistically significant down regulation of XRCC2 (p

Published
2014

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