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633 results on '"Nabi, Faisal"'

1. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Stuijfzand, Wijnand J., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, de Waard, Guus A., Sprengers, Ralf W., Raijmakers, Pieter G., Nurmohamed, Nick S., Danad, Ibrahim, Jukema, Ruurt A., de Winter, Ruben W., de Groot, Robin J., Driessen, Roel S., Bom, Michiel J., van Diemen, Pepijn, Pontone, Gianluca, Andreini, Daniele, Chang, Hyuk-Jae, Katz, Richard J., Stroes, Erik S.G., Wang, Hao, Chan, Chung, Crabtree, Tami, Aquino, Melissa, Min, James K., Earls, James P., Bax, Jeroen J., Choi, Andrew D., Knaapen, Paul, and van Rosendael, Alexander R.

Published
2024
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8. Rationale and design of the CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) study

Author

van Rosendael, Alexander R., Crabtree, Tami, Bax, Jeroen J., Nakanishi, Rine, Mushtaq, Saima, Pontone, Gianluca, Andreini, Daniele, Buechel, Ronny R., Gräni, Christoph, Feuchtner, Gudrun, Patel, Toral R., Choi, Andrew D., Al-Mallah, Mouaz, Nabi, Faisal, Karlsberg, Ronald P., Rochitte, Carlos E., Alasnag, Mirvat, Hamdan, Ashraf, Cademartiri, Filippo, Marques, Hugo, Kalra, Dinesh, German, David M., Gupta, Himanshu, Hadamitzky, Martin, Deaño, Roderick C., Khalique, Omar, Knaapen, Paul, Hoffmann, Udo, Earls, James, Min, James K., and Danad, Ibrahim

Published
2024
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11. Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity

Author

Jonas, Rebecca, Patel, Toral, Crabtree, Tami R., Jennings, Robert S., Heo, Ran, Park, Hyung-Bok, Marques, Hugo, Chang, Hyuk-Jae, Stuijfzand, Wijnand J., van Rosendael, Alexander R., Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Al-Mallah, Mouaz H., Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, Bax, Jeroen J., Choi, Andrew D., Earls, James P., Hoffmann, Udo, Min, James K., and Villines, Todd C.

Published
2023
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16. AI Evaluation of Stenosis on Coronary CTA, Comparison With Quantitative Coronary Angiography and Fractional Flow Reserve: A CREDENCE Trial Substudy

Author

Griffin, William F., Choi, Andrew D., Riess, Joanna S., Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall, Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, and Earls, James P.

Published
2023
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28. The effect of scan and patient parameters on the diagnostic performance of AI for detecting coronary stenosis on coronary CT angiography

Author

Jonas, Rebecca A., Barkovich, Emil, Choi, Andrew D., Griffin, William F., Riess, Joanna, Marques, Hugo, Chang, Hyuk-Jae, Choi, Jung Hyun, Doh, Joon-Hyung, Her, Ae-Young, Koo, Bon-Kwon, Nam, Chang-Wook, Park, Hyung-Bok, Shin, Sang-Hoon, Cole, Jason, Gimelli, Alessia, Khan, Muhammad Akram, Lu, Bin, Gao, Yang, Nabi, Faisal, Nakazato, Ryo, Schoepf, U. Joseph, Driessen, Roel S., Bom, Michiel J., Thompson, Randall C., Jang, James J., Ridner, Michael, Rowan, Chris, Avelar, Erick, Généreux, Philippe, Knaapen, Paul, de Waard, Guus A., Pontone, Gianluca, Andreini, Daniele, Guglielmo, Marco, Al-Mallah, Mouaz H., Jennings, Robert S., Crabtree, Tami R., and Earls, James P.

Published
2022
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29. A Case Study of Cyber Subversion Attack based Design Flaw in Service Oriented Component Application Logic.

Author

Nabi, Faisal, Zhou, Xujuan, Iftikhar, Umna, and Attaullah, Hafiz Muhammad

Subjects
CYBERTERRORISM, DESIGN services, SERVICE design, SERVICE-oriented architecture (Computer science), LOGIC, TRANSACTION systems (Computer systems), ASSURANCE services
Abstract

Modern e-commerce systems are more likely focused on mechanisms of security, such as secure transactional protocols, cryptographic schemes and parameter sanitization, and it is assumed that putting these in place will guarantee a secure e-commerce application. However, vulnerabilities in the business application logic itself are often ignored which can make the effect of these security mechanisms null and void. Essentially, the weakest link can be at the server rather than client because of business logic and insecure server-side business components, its security ignoring is another factor, which is done at developer's peril. This paper focuses on the weakest link (component's logic subversion) in the e-commerce system. We outline a logical attack (subversion attack, class Design Flaw) that would not be prevented by the deployment of the mechanisms commonly used in e-commerce systems. To further investigate this problem, we propose a security assurance methodology for service component-oriented application that will be practiced through threat modeling and component fault detection model with further modeling component and its application using unified modeling language secure-design approach with a valid technique (verification, validation model for security-by-design testing) for design flaw detection to avoid the business logic problem in component-based e-commerce applications from existing application logic. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Natural compound plumbagin based inhibition of hIAPP revealed by Markov state models based on MD data along with experimental validations.

Author

Nabi, Faisal, Ahmad, Owais, Khan, Adeeba, Hassan, Md Nadir, Hisamuddin, Malik, Malik, Sadia, Chaari, Ali, and Khan, Rizwan Hasan

Abstract

Human islet amyloid polypeptide (amylin or hIAPP) is a 37 residue hormone co‐secreted with insulin from β cells of the pancreas. In patients suffering from type‐2 diabetes, amylin self‐assembles into amyloid fibrils, ultimately leading to the death of the pancreatic cells. However, a research gap exists in preventing and treating such amyloidosis. Plumbagin, a natural compound, has previously been demonstrated to have inhibitory potential against insulin amyloidosis. Our investigation unveils collapsible regions within hIAPP that, upon collapse, facilitates hydrophobic and pi‐pi interactions, ultimately leading to aggregation. Intriguingly plumbagin exhibits the ability to bind these specific collapsible regions, thereby impeding the aforementioned interactions that would otherwise drive hIAPP aggregation. We have used atomistic molecular dynamics approach to determine secondary structural changes. MSM shows metastable states forming native like hIAPP structure in presence of PGN. Our in silico results concur with in vitro results. The ThT assay revealed a striking 50% decrease in fluorescence intensity at a 1:1 ratio of hIAPP to Plumbagin. This finding suggests a significant inhibition of amyloid fibril formation by plumbagin, as ThT fluorescence directly correlates with the presence of these fibrils. Further TEM images revealed disappearance of hIAPP fibrils in plumbagin pre‐treated hIAPP samples. Also, we have shown that plumbagin disrupts the intermolecular hydrogen bonding in hIAPP fibrils leading to an increase in the average beta strand spacing, thereby causing disaggregation of pre‐formed fibrils demonstrating overall disruption of the aggregation machinery of hIAPP. Our work is the first to report a detailed atomistic simulation of 22 μs for hIAPP. Overall, our studies put plumbagin as a potential candidate for both preventive and therapeutic candidate for hIAPP amyloidosis. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia

Author

Nurmohamed, Nick S., primary, Danad, Ibrahim, additional, Jukema, Ruurt A., additional, de Winter, Ruben W., additional, de Groot, Robin J., additional, Driessen, Roel S., additional, Bom, Michiel J., additional, van Diemen, Pepijn, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Chang, Hyuk-Jae, additional, Katz, Richard J., additional, Stroes, Erik S.G., additional, Wang, Hao, additional, Chan, Chung, additional, Crabtree, Tami, additional, Aquino, Melissa, additional, Min, James K., additional, Earls, James P., additional, Bax, Jeroen J., additional, Choi, Andrew D., additional, Knaapen, Paul, additional, van Rosendael, Alexander R., additional, Heo, Ran, additional, Park, Hyung-Bok, additional, Marques, Hugo, additional, Stuijfzand, Wijnand J., additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Al-Mallah, Mouaz H., additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, de Waard, Guus A., additional, Sprengers, Ralf W., additional, and Raijmakers, Pieter G., additional

Published
2024
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41. Extracellular Volume in Primary Mitral Regurgitation

Author

Kitkungvan, Danai, Yang, Eric Y., El Tallawi, Kinan C., Nagueh, Sherif F., Nabi, Faisal, Khan, Mohammad A., Nguyen, Duc T., Graviss, Edward A., Lawrie, Gerald M., Zoghbi, William A., Bonow, Robert O., Quinones, Miguel A., and Shah, Dipan J.

Published
2021
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42. Rationale and design of the CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) study

Author

Cardiologie, Team Medisch, van Rosendael, Alexander R., Crabtree, Tami, Bax, Jeroen J., Nakanishi, Rine, Mushtaq, Saima, Pontone, Gianluca, Andreini, Daniele, Buechel, Ronny R., Gräni, Christoph, Feuchtner, Gudrun, Patel, Toral R., Choi, Andrew D., Al-Mallah, Mouaz, Nabi, Faisal, Karlsberg, Ronald P., Rochitte, Carlos E., Alasnag, Mirvat, Hamdan, Ashraf, Cademartiri, Filippo, Marques, Hugo, Kalra, Dinesh, German, David M., Gupta, Himanshu, Hadamitzky, Martin, Deaño, Roderick C., Khalique, Omar, Knaapen, Paul, Hoffmann, Udo, Earls, James, Min, James K., Danad, Ibrahim, The CONFIRM 2 investigators, Cardiologie, Team Medisch, van Rosendael, Alexander R., Crabtree, Tami, Bax, Jeroen J., Nakanishi, Rine, Mushtaq, Saima, Pontone, Gianluca, Andreini, Daniele, Buechel, Ronny R., Gräni, Christoph, Feuchtner, Gudrun, Patel, Toral R., Choi, Andrew D., Al-Mallah, Mouaz, Nabi, Faisal, Karlsberg, Ronald P., Rochitte, Carlos E., Alasnag, Mirvat, Hamdan, Ashraf, Cademartiri, Filippo, Marques, Hugo, Kalra, Dinesh, German, David M., Gupta, Himanshu, Hadamitzky, Martin, Deaño, Roderick C., Khalique, Omar, Knaapen, Paul, Hoffmann, Udo, Earls, James, Min, James K., Danad, Ibrahim, and The CONFIRM 2 investigators

Published
2024

43. Rationale and design of the CONFIRM2 (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) study

Author

van Rosendael, Alexander R, Crabtree, Tami, Bax, Jeroen J, Nakanishi, Rine, Mushtaq, Saima, Pontone, Gianluca, Andreini, Daniele, Buechel, Ronny R; https://orcid.org/0000-0001-8064-8904, Gräni, Christoph, Feuchtner, Gudrun, Patel, Toral R, Choi, Andrew D, Al-Mallah, Mouaz, Nabi, Faisal, Karlsberg, Ronald P, Rochitte, Carlos E, Alasnag, Mirvat, Hamdan, Ashraf, Cademartiri, Filippo, Marques, Hugo, Kalra, Dinesh, German, David M, Gupta, Himanshu, Hadamitzky, Martin, Deaño, Roderick C, Khalique, Omar, Knaapen, Paul, Hoffmann, Udo, Earls, James, Min, James K, et al, van Rosendael, Alexander R, Crabtree, Tami, Bax, Jeroen J, Nakanishi, Rine, Mushtaq, Saima, Pontone, Gianluca, Andreini, Daniele, Buechel, Ronny R; https://orcid.org/0000-0001-8064-8904, Gräni, Christoph, Feuchtner, Gudrun, Patel, Toral R, Choi, Andrew D, Al-Mallah, Mouaz, Nabi, Faisal, Karlsberg, Ronald P, Rochitte, Carlos E, Alasnag, Mirvat, Hamdan, Ashraf, Cademartiri, Filippo, Marques, Hugo, Kalra, Dinesh, German, David M, Gupta, Himanshu, Hadamitzky, Martin, Deaño, Roderick C, Khalique, Omar, Knaapen, Paul, Hoffmann, Udo, Earls, James, Min, James K, and et al

Abstract

BACKGROUND In the last 15 years, large registries and several randomized clinical trials have demonstrated the diagnostic and prognostic value of coronary computed tomography angiography (CCTA). Advances in CT scanner technology and developments of analytic tools now enable accurate quantification of coronary artery disease (CAD), including total coronary plaque volume and low attenuation plaque volume. The primary aim of CONFIRM2, (Quantitative COroNary CT Angiography Evaluation For Evaluation of Clinical Outcomes: An InteRnational, Multicenter Registry) is to perform comprehensive quantification of CCTA findings, including coronary, non-coronary cardiac, non-cardiac vascular, non-cardiac findings, and relate them to clinical variables and cardiovascular clinical outcomes. DESIGN CONFIRM2 is a multicenter, international observational cohort study designed to evaluate multidimensional associations between quantitative phenotype of cardiovascular disease and future adverse clinical outcomes in subjects undergoing clinically indicated CCTA. The targeted population is heterogenous and includes patients undergoing CCTA for atherosclerotic evaluation, valvular heart disease, congenital heart disease or pre-procedural evaluation. Automated software will be utilized for quantification of coronary plaque, stenosis, vascular morphology and cardiac structures for rapid and reproducible tissue characterization. Up to 30,000 patients will be included from up to 50 international multi-continental clinical CCTA sites and followed for 3-4 years. SUMMARY CONFIRM2 is one of the largest CCTA studies to establish the clinical value of a multiparametric approach to quantify the phenotype of cardiovascular disease by CCTA using automated imaging solutions.

Published
2024

50. Corrigendum to ‘Relation of Gender to Atherosclerotic Plaque Characteristics by Differing Angiographic Stenosis Severity’ The American Journal of Cardiology, Volume 204, 1 October 2023, Pages 276-283

Author

Jonas, Rebecca, primary, Patel, Toral, additional, Crabtree, Tami R., additional, Jennings, Robert S., additional, Heo, Ran, additional, Park, Hyung-Bok, additional, Marques, Hugo, additional, Chang, Hyuk-Jae, additional, Stuijfzand, Wijnand J., additional, Rosendael, Alexander R. van, additional, Choi, Jung Hyun, additional, Doh, Joon-Hyung, additional, Her, Ae-Young, additional, Koo, Bon-Kwon, additional, Nam, Chang-Wook, additional, Shin, Sang-Hoon, additional, Cole, Jason, additional, Gimelli, Alessia, additional, Khan, Muhammad Akram, additional, Lu, Bin, additional, Gao, Yang, additional, Nabi, Faisal, additional, Al-Mallah, Mouaz H., additional, Nakazato, Ryo, additional, Schoepf, U. Joseph, additional, Driessen, Roel S., additional, Bom, Michiel J., additional, Thompson, Randall C., additional, Jang, James J., additional, Ridner, Michael, additional, Rowan, Chris, additional, Avelar, Erick, additional, Généreux, Philippe, additional, Knaapen, Paul, additional, de Waard, Guus A., additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Bax, Jeroen J., additional, Choi, Andrew D., additional, Earls, James P., additional, Hoffmann, Udo, additional, Min, James K., additional, and Villines, Todd C., additional

Published
2023
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