Author: "Nabhan AN" - Searchworks@Jio Institute Digital Library Search Results

7,330 results on '"Nabhan AN"'

1. Molecular analysis of primary and metastatic sites in patients with renal cell carcinoma.

Author: Gulati, Shuchi, Barata, Pedro, Elliott, Andrew, Bilen, Mehmet, Burgess, Earle, Choueiri, Toni, Darabi, Sourat, Dawson, Nancy, Gartrell, Benjamin, Hammers, Hans, Heath, Elisabeth, Magee, Daniel, Rao, Arpit, Ryan, Charles, Twardowski, Przemyslaw, Wei, Shuanzeng, Brugarolas, James, Zhang, Tian, Zibelman, Matthew, Nabhan, Chadi, and McKay, Rana
Subjects: Cancer, Oncology, Humans, Carcinoma, Renal Cell, Kidney Neoplasms, Tumor Microenvironment, Female, Male, Neoplasm Metastasis, Transcriptome, Middle Aged, Gene Expression Regulation, Neoplastic, Aged
Abstract: BACKGROUNDMetastases are the hallmark of lethal cancer, though underlying mechanisms that drive metastatic spread to specific organs remain poorly understood. Renal cell carcinoma (RCC) is known to have distinct sites of metastases, with lung, bone, liver, and lymph nodes being more common than brain, gastrointestinal tract, and endocrine glands. Previous studies have shown varying clinical behavior and prognosis associated with the site of metastatic spread; however, little is known about the molecular underpinnings that contribute to the differential outcomes observed by the site of metastasis.METHODSWe analyzed primary renal tumors and tumors derived from metastatic sites to comprehensively characterize genomic and transcriptomic features of tumor cells as well as to evaluate the tumor microenvironment at both sites.RESULTSWe included a total of 657 tumor samples (340 from the primary site [kidney] and 317 from various sites of metastasis). We show distinct genomic alterations, transcriptomic signatures, and immune and stromal tumor microenvironments across metastatic sites in a large cohort of patients with RCC.CONCLUSIONWe demonstrate significant heterogeneity among primary tumors and metastatic sites and elucidate the complex interplay between tumor cells and the extrinsic tumor microenvironment that is vital for developing effective anticancer therapies.
Published: 2024

2. Renal cell carcinoma histologic subtypes exhibit distinct transcriptional profiles.

Author: Barata, Pedro, Gulati, Shuchi, Elliott, Andrew, Hammers, Hans, Burgess, Earle, Gartrell, Benjamin, Darabi, Sourat, Bilen, Mehmet, Basu, Arnab, Geynisman, Daniel, Dawson, Nancy, Zibelman, Matthew, Zhang, Tian, Wei, Shuanzeng, Ryan, Charles, Heath, Elisabeth, Poorman, Kelsey, Nabhan, Chadi, and McKay, Rana
Subjects: Cancer, Genetics, Molecular genetics, Oncology, Urology, Humans, Carcinoma, Renal Cell, Kidney Neoplasms, Transcriptome, Female, Male, Gene Expression Regulation, Neoplastic, Middle Aged, Aged, Neoplasm Proteins, Gene Expression Profiling
Abstract: Molecular profiling of clear cell renal cell carcinoma (ccRCC) tumors of patients in a clinical trial has identified distinct transcriptomic signatures with predictive value, yet data in non-clear cell variants (nccRCC) are lacking. We examined the transcriptional profiles of RCC tumors representing key molecular pathways, from a multi-institutional, real-world patient cohort, including ccRCC and centrally reviewed nccRCC samples. ccRCC had increased angiogenesis signature scores compared with the heterogeneous group of nccRCC tumors, while cell cycle, fatty acid oxidation/AMPK signaling, and fatty acid synthesis/pentose phosphate signature scores were increased in one or more nccRCC subtypes. Among both ccRCC and nccRCC tumors, T effector scores statistically correlated with increased immune cell infiltration and were more commonly associated with immunotherapy-related markers (PD-L1+/TMBhi/MSIhi). In conclusion, this study provides evidence of differential gene transcriptional profiles among ccRCC versus nccRCC tumors, providing insights for optimizing personalized and histology-specific therapeutic strategies for patients with advanced RCC.
Published: 2024

3. Characterization and impact of non-canonical WNT signaling on outcomes of urothelial carcinoma.

Author: Meagher, Margaret, Krause, Harris, Elliott, Andrew, Farrell, Alex, Antonarakis, Emmanuel, Bastos, Bruno, Heath, Elisabeth, Jamieson, Christina, Stewart, Tyler, Bagrodia, Aditya, Nabhan, Chadi, Oberley, Matt, McKay, Rana, and Salmasi, Amirali
Subjects: FZD2, Non‐canonical, ROR, Urothelial carcinoma, WNT signaling, WNT5A, Humans, Wnt Proteins, Carcinoma, Transitional Cell, Urinary Bladder Neoplasms, Wnt Signaling Pathway, Receptor Tyrosine Kinase-like Orphan Receptors, Wnt-5a Protein
Abstract: BACKGROUND: Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. METHODS: NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as ≥ top and
Published: 2024

4. Surgical Evaluation of Autologous Platelet-rich Fibrin Membrane as a Coverage Layer in Repair of Urethrocutaneous Fistula after Hypospadias Surgeries: A Randomized Controlled Trial

Author: Wishahy, Ahmed Mohamed Kadry, Abdullateef, Khaled Salah Ahmed, Kaddah, Sherif Nabhan, Mohamed, Alaa Ali, and Mohamed, Mahmoud Tarek
Subjects: Medical research -- Analysis, Medicine, Experimental -- Analysis, Fistula -- Analysis, Hypospadias -- Analysis, Clinical trials -- Analysis, Fibrin -- Analysis
Abstract: ABSTRACT Purpose: It has recently been reported that the use of platelet-rich fibrin (PRF) as an extralayer over the urethroplasty has been related to a considerable reduction in fistula rates. Due to the lack of evidence supporting the usage of PRF in urethrocutaneous fistula (UCF) repair, we conducted this study to evaluate the efficacy of PRF in patients with UCF. Materials and Methods: We conducted a randomized controlled study on patients with distal fistula after hypospadias repair. Patients were randomized into two groups, one with local dartos coverage and the other with PRF coverage layer. Results: In the present study, we included 37 patients; 20 patients underwent local dartos coverage, and 17 patients underwent PRF. The mean age was 22.45 ± 4545 ± 4515 ± ±15.35 (range 11-56) months for the study group and 20.6 ± 66 ± 614 ± ±14.5 (range 6-45) months for the control group. The incidence of recurrent UCF was 11.8 in the treatment group (two patients), whereas the incidence was 30 (six patients) in the control group (P = 0.246). Conclusion: UCF surgery may benefit from the use of PRF as a supportive tissue that promotes wound healing, angiogenesis, and tissue restoration. We believe that the use of PRF as a new approach for UCF repair should be investigated further through clinical studies. Keywords: Fibrin glue, platelet-rich fibrin, urethrocutaneous fistula, Author(s): Ahmed Mohamed Kadry Wishahy [1]; Khaled Salah Ahmed Abdullateef [1]; Sherif Nabhan Kaddah [1]; Alaa Ali Mohamed [1]; Mahmoud Tarek Mohamed (corresponding author) [1] INTRODUCTION One in every 200-300 [...]
Published: 2024
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5. Ethnography and Catholic Studies: Reflections and Observations

Author: Nabhan-Warren, Kristy
Published: 2024
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6. The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease

Author: Martina B. William, Sharifa Hamed, Ali Shalash, Eman M. Khedr, Mohamed H. Yousef, Shaimaa El-Jaafary, Gharib Fawi, Asmaa Helmy, Eman Hamid, Mohamed Essam, Hamin Lee, Alina Jama, Mohamed Koraym, Doaa M. Mahmoud, Sara Elfarrash, Yasmin Elsaid, Asmaa S. Gabr, Nourhan Shebl, Nesreen Abdelwahhab, Tamer M. Belal, Nehal A. B. Elsayed, Mohamed El-Gamal, Shimaa Elgamal, Salma Ragab, Jaidaa Mekky, Lobna Aly, Samir Nabhan, Gaafar Ragab, Mohamed A. Hussein, Mohamed Tharwat Hegazy, Henry Houlden, Mohamed Salama, and Mie Rizig
Subjects: Neurology. Diseases of the nervous system, RC346-429
Abstract: Abstract The impact of LRRK2 variants on the risk of Parkinson’s disease in Egyptians remains unknown. We examined 1210 Egyptians (611 PD patients and 599 controls) from 16 governorates across Egypt for 12 LRRK2 pathogenic variants. The p.Gly2019Ser was the only variant detected, with a prevalence of 4.1% in sporadic cases, 6.5% in familial cases, and 0.68% in controls. Among p.Gly2019Ser carriers, all were heterozygous bar one homozygous patient, and all shared the common haplotype 1. Demographics and UPDRS scores did not differ between carriers and non-carriers, with most patients being males and developed PD in their fifties. Young and Early-onset PD prevalence was 37.5% in carriers and 33% in non-carriers. Familial cases were 16.6% in carriers and 11.5% in non-carriers. This study affirms that like other Mediterranean populations, Egyptians with PD have a higher prevalence of the p.Gly2019Ser variant compared to the global average. LRRK2 inhibitors could be promising therapeutic options for further exploration in this population.
Published: 2024
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7. Driver mutations associated with signatures of platinum sensitivity in germ cell tumors

Author: Yun Cheng Sawa, Liwei Jia, Harris Krause, Margaret Meagher, Frederick Millard, Andrew Elliott, John T. Lafin, Christina Jamieson, Emmanuel S. Antonarakis, Anishka D’Souza, Krinio Giannikou, James F. Amatruda, Siamak Daneshmand, Rana R. McKay, Matthew Oberley, Chadi Nabhan, and Aditya Bagrodia
Subjects: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Abstract We sought to evaluate the genomic and transcriptomic landscapes in primary and metastatic germ cell tumors (GCTs; N = 138) to uncover factors that drive cisplatin resistance. Prevalence was calculated for platinum-resistant alterations (PRAs; KRAS, TP53, and KIT mutations, and MDM2 amplification) and high copy number amplifications (CNA ≥ 6 copies). Tumors were designated as chemo-naïve (PreC, N = 66) or post-chemotherapy (PostC, N = 17). A transcriptomic signature associated with platinum sensitivity (PSS, high suggests increased sensitivity) was applied. KIT mutations were observed in 14.5% of primary versus 1.8% of met and 0% of lymph. TP53 mutations were identified in 10% of primary GCTs versus 17% of met and 16.7% of lymph. MDM2 CNAs were similar between sites. PRA-positive PreC GCTs had significantly lower average PSS scores compared to PRA-negative tumors. Lower PSS scores in chemo-naïve tumors were associated with PRAs, suggesting a potential mechanism for platinum resistance.
Published: 2024
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8. Dental students, interns, and junior dentists’ awareness and attitude toward the inferior alveolar nerve block technique and related failure

Author: Salah Sakka, Nasser Raqe Alqhtani, Abdullah Saad Alqahtani, Abdullah Bin Nabhan, Mohamed Kamal Eid, Maram Alagla, Khalid Alfaifi, and Mohammad Zakaria Nassani
Subjects: Dental education, Local anesthetic, Dentists' perception, Inferior alveolar nerve, Dentistry, RK1-715
Abstract: Background/purpose: Exploration of early practicing dental professionals' awareness and attitude toward inferior alveolar nerve block IANB will directly inform efforts to improve clinical practices and ensure patient safety. The aim was to highlight the students, interns, and junior dentists’ awareness and attitude toward the IANB, failure, and related complications in the Kingdom of Saudi Arabia (KSA). Materials and methods: An open web-based survey prepared according to the Checklist for reporting results of Internet e-surveys CHERRIES recommendations was designed and carried out across different regions of the KSA. The questionnaire was composed of four main sections including the participant's details, and qualifications; inferior alveolar nerve block delivery; participants' education, and training-related questions; and attitudes toward proposed solutions to overcome the related failure and complications. Results: 262 participants completed the questionnaire (94 dental students, 79 interns, and 89 junior dentists). There was a significant difference in the following findings: males performed IANBs more frequently than females (P
Published: 2024
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9. Surgical Evaluation of Autologous Platelet-rich Fibrin Membrane as a Coverage Layer in Repair of Urethrocutaneous Fistula after Hypospadias Surgeries: A Randomized Controlled Trial

Author: Ahmed Mohamed Kadry Wishahy, Khaled Salah Ahmed Abdullateef, Sherif Nabhan Kaddah, Alaa Ali Mohamed, and Mahmoud Tarek Mohamed
Subjects: fibrin glue, platelet-rich fibrin, urethrocutaneous fistula, Pediatrics, RJ1-570, Surgery, RD1-811
Abstract: Purpose: It has recently been reported that the use of platelet-rich fibrin (PRF) as an extralayer over the urethroplasty has been related to a considerable reduction in fistula rates. Due to the lack of evidence supporting the usage of PRF in urethrocutaneous fistula (UCF) repair, we conducted this study to evaluate the efficacy of PRF in patients with UCF. MATERIALS AND METHODS: We conducted a randomized controlled study on patients with distal fistula after hypospadias repair. Patients were randomized into two groups, one with local dartos coverage and the other with PRF coverage layer. Results: In the present study, we included 37 patients; 20 patients underwent local dartos coverage, and 17 patients underwent PRF. The mean age was 22.45 ± 4545 ± 4515 ± ±15.35 (range 11–56) months for the study group and 20.6 ± 66 ± 614 ± ±14.5 (range 6–45) months for the control group. The incidence of recurrent UCF was 11.8% in the treatment group (two patients), whereas the incidence was 30% (six patients) in the control group (P = 0.246). Conclusion: UCF surgery may benefit from the use of PRF as a supportive tissue that promotes wound healing, angiogenesis, and tissue restoration. We believe that the use of PRF as a new approach for UCF repair should be investigated further through clinical studies.
Published: 2024
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10. The dawn of ethnomicrobiology: an interdisciplinary research field on interactions between humans and microorganisms

Author: César Ojeda-Linares, Alejandro Casas, Tania González-Rivadeneira, and Gary P. Nabhan
Subjects: Ethnobiology, Microbiology, Traditional ecological knowledge, Sustainability, Social justice, Other systems of medicine, RZ201-999, Botany, QK1-989
Abstract: Abstract Background Ethnobiologists commonly analyze local knowledge systems related to plants, animals, fungi, and ecosystems. However, microbes (bacteria, yeasts, molds, viruses, and other organisms), often considered invisible in their interactions with humans, are often neglected. Microorganisms were the earliest life forms on Earth, and humans have interacted with them throughout history. Over time, humans have accumulated ecological knowledge about microbes through attributes such as smell, taste, and texture that guide the management of contexts in which microorganisms evolve. These human-microbe interactions are, in fact, expressions of biocultural diversity. Thus, we propose that ethnomicrobiology is a distinct interdisciplinary field within ethnobiology that examines the management practices and knowledge surrounding human-microbe interactions, along with the theoretical contributions that such an approach can offer. Methods We reviewed scientific journals, books, and chapters exploring human-microbe relationships. Our search included databases such as Web of Science, Scopus, Google Scholar, and specific journal websites, using keywords related to ethnomicrobiology and ethnozymology. To categorize activities involving deliberate human-microbial interactions, we examined topics such as fermentation, pickling, food preservation, silaging, tanning, drying, salting, smoking, traditional medicine, folk medicine, agricultural practices, composting, and other related practices. Results Our research identified important precedents for ethnomicrobiology through practical and theoretical insights into human-microbe interactions, particularly in their impact on health, soil, and food systems. We also found that these interactions contribute to biodiversity conservation and co-evolutionary processes. This emerging interdisciplinary field has implications for food ecology, public health, and the biocultural conservation of hidden microbial landscapes and communities. It is essential to explore the socioecological implications of the interwoven relationships between microbial communities and humans. Equally important is the promotion of the conservation and recovery of this vast biocultural diversity, along with sustainable management practices informed by local ecological knowledge. Conclusion Recognizing the dawn of ethnomicrobiology is essential as the field evolves from a descriptive to a more theoretical and integrative biological approach. We emphasize the critical role that traditional communities have played in conserving food, agriculture, and health systems. This emerging field highlights that the future of ethnobiological sciences will focus not on individual organisms or cultures, but on the symbiosis between microorganisms and humans that has shaped invisible but often complex biocultural landscapes.
Published: 2024
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11. The Genomic Landscape of Vulvar Squamous Cell Carcinoma.

Author: Corey, Logan, Wallbillich, John, Wu, Sharon, Farrell, Alex, Hodges, Kurt, Xiu, Joanne, Nabhan, Chadi, Guastella, Anthony, Kheil, Mira, Gogoi, Radhika, Winer, Ira, Bandyopadhyay, Sudeshna, Huang, Marilyn, Jones, Nathaniel, Wilhite, Annelise, Thaker, Premal, Herzog, Thomas, Oberley, Matthew, Korn, William, Vezina, Alex, Morris, Robert, Ali-Fehmi, Rouba, and Karnezis, Anthony
Abstract: Vulvar squamous cell cancer (VSC) accounts for 90% of vulvar cancers. Next-generation sequencing studies of VSC imply human papillomavirus (HPV) and p53 status play separate roles in carcinogenesis and prognosis. We sought to describe the genomic landscape and analyze the immunologic profiles of VSC with respect to HPV and p53 status. A total of 443 VSC tumors underwent tumor profiling. Next-generation sequencing was performed on genomic DNA isolated from formalin-fixed paraffin-embedded tumor samples. PD-L1, microsatellite instability were tested by fragment analysis, IHC, and next-generation sequencing. Tumor mutational burden-high was defined as >10 mutations per MB. HPV 16/18 positive (HPV+) status was determined using whole exome sequencing on 105 samples. Three cohorts were identified from 105 samples with known HPV: HPV+, HPV-/p53wt, and HPV-/p53mt. Where HPV and p53 status were examined, TP53 mutations were exclusive of HPV+ tumors. In all, 37% of samples were HPV+. Among the 66 HPV- tumors, 52 (78.8%) were HPV-/p53mt and 14 (21.2%) were HPV-/p53wt. The HPV-/p53wt cohort had a higher rate of mutations in the PI3KCA gene (42.9% HPV-/p53wt vs 26.3% HPV+ vs. 5.8% HPV-/p53mt, q =0.028) and alterations in the PI3K/AkT/mTOR pathway (57.1% HPV-/p53wt vs. 34.2% HPV+ vs. 7.7% HPV-/p53mt, q =0.0386) than the other 2 cohorts. Ninety-eight VSC tumors with HPV16/18 information underwent transcriptomic analysis and immune deconvolution method. No differences were observed in immune profiles. The HPV-/p53wt VSC tumors had significantly higher rates of mutations in the PI3KCA gene and alterations in the PI3K/AkT/mTOR pathway, a potential target that merits further investigation in this subgroup.
Published: 2023

12. The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease

Author: William, Martina B., Hamed, Sharifa, Shalash, Ali, Khedr, Eman M., Yousef, Mohamed H., El-Jaafary, Shaimaa, Fawi, Gharib, Helmy, Asmaa, Hamid, Eman, Essam, Mohamed, Lee, Hamin, Jama, Alina, Koraym, Mohamed, Mahmoud, Doaa M., Elfarrash, Sara, Elsaid, Yasmin, Gabr, Asmaa S., Shebl, Nourhan, Abdelwahhab, Nesreen, Belal, Tamer M., Elsayed, Nehal A. B., El-Gamal, Mohamed, Elgamal, Shimaa, Ragab, Salma, Mekky, Jaidaa, Aly, Lobna, Nabhan, Samir, Ragab, Gaafar, Hussein, Mohamed A., Hegazy, Mohamed Tharwat, Houlden, Henry, Salama, Mohamed, and Rizig, Mie
Published: 2024
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13. Driver mutations associated with signatures of platinum sensitivity in germ cell tumors

Author: Sawa, Yun Cheng, Jia, Liwei, Krause, Harris, Meagher, Margaret, Millard, Frederick, Elliott, Andrew, Lafin, John T., Jamieson, Christina, Antonarakis, Emmanuel S., D’Souza, Anishka, Giannikou, Krinio, Amatruda, James F., Daneshmand, Siamak, McKay, Rana R., Oberley, Matthew, Nabhan, Chadi, and Bagrodia, Aditya
Published: 2024
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14. The dawn of ethnomicrobiology: an interdisciplinary research field on interactions between humans and microorganisms

Author: Ojeda-Linares, César, Casas, Alejandro, González-Rivadeneira, Tania, and Nabhan, Gary P.
Published: 2024
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15. Biological comparisons between pre-eclampsia and placenta accreta spectrum

Author: Bartels, Helena C., Hameed, Sodiq, Young, Constance, Nabhan, Myriam, Downey, Paul, Curran, Kathleen M., McCormack, Janet, Fabre, Aurelie, Kolch, Walter, Zhernovkov, Vadim, and Brennan, Donal J.
Published: 2024
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16. Cervical cancer screening by cytology and the burden of epithelial abnormalities in low resource settings: a tertiary-center 42-year study

Author: Ezzelarab, Sahar, El-Husseiny, Amro, Nasreldin, Magda, Ali, Radwa, and Nabhan, Ashraf
Published: 2024
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17. Prevalence of anxiety and depression among Lebanese women using oral contraceptives: a cross-sectional study

Author: Jaafar, Kamel, Nabhan, Elias, Daoud, Rama, and Nasser, Zeina
Published: 2024
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18. Biological comparisons between pre-eclampsia and placenta accreta spectrum

Author: Helena C. Bartels, Sodiq Hameed, Constance Young, Myriam Nabhan, Paul Downey, Kathleen M. Curran, Janet McCormack, Aurelie Fabre, Walter Kolch, Vadim Zhernovkov, and Donal J. Brennan
Subjects: Women. Feminism, HQ1101-2030.7, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Abstract Placenta Accreta Spectrum (PAS) and pre-eclampsia are obstetric disorders associated with significant maternal morbidity and mortality. As pre-eclampsia is characterised by shallow placental invasion and PAS by abnormally deep invasion, we sought to compare the biological processes dysregulated in PAS to those reported in pre-eclampsia. We demonstrate that many of the processes contributing to unregulated placental invasion in PAS are the mirror findings of those previously reported in pre-eclampsia. These comparisons of PAS to a more common obstetric condition allow a greater understanding of the biological processes contributing to PAS, which remains a very rare obstetric complication.
Published: 2024
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19. Cervical cancer screening by cytology and the burden of epithelial abnormalities in low resource settings: a tertiary-center 42-year study

Author: Sahar Ezzelarab, Amro El-Husseiny, Magda Nasreldin, Radwa Ali, Ashraf Nabhan, and Early Cervical Cancer Detection Consortium
Subjects: Pap smear, Early detection of cancer, Cancer screening, Uterine cervical neoplasms, Cervical cancer, Squamous intraepithelial lesions of the cervix, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270
Abstract: Abstract Background Cytological screening remains a high-impact practice, particularly in low-resource settings, for preventing cervical cancer. The examination of screening practices over time and the prevalence of epithelial abnormalities have not been investigated in longitudinal studies in one of the largest countries in the Middle East and Africa. Methods Routine healthcare data, between March 1981 and December 2022, were extracted from the database of the Early Cancer Detection Unit in a tertiary referral university hospital in the Greater Cairo Region, Egypt. Cervical smears were obtained using a standardized technique and sent to the cytopathology laboratory for conventional cytology examination by expert pathologists. The anonymous data were analyzed to determine the temporal trend of the number of women screened each year and the prevalence of epithelial abnormalities. Results Data included the results of satisfactory smears from 95120 women. The mean age (SD) of the women at the time of screening was 38.5 (10.5). None of the included women received an HPV vaccine. Abnormal epithelial cells were reported in 5174 women (5.44%). Of these epithelial abnormalities, the majority were low-grade squamous intraepithelial lesions in 4144 women (4.36%). Other abnormalities included atypical squamous cells in 378 women (0.40%), high-grade squamous intraepithelial lesions in 226 women (0.24%), atypical glandular cells not otherwise specified in 184 women (0.19%), adenocarcinoma in 165 women (0.17%), squamous cell carcinoma in 70 women (0.07%), and atypical glandular cells favoring neoplasms in 7 women (0.01%). Women who were at an early age at first intercourse, those who opted for routine cervical cytology screening, and those who were older at screening were more likely to have epithelial abnormalities. The yearly number of screened women was positively associated with the detection of low-grade squamous intraepithelial lesions (correlation coefficient [95% CI] = 0.84 [0.72, 0.91]) and negatively associated with the detection of squamous cell carcinoma (correlation coefficient [95% CI] = -0.55 [-0.73, -0.29]). Conclusions The small number of annually screened Egyptian women and the temporal trend in epithelial abnormalities critically demonstrate the need for establishing and scaling up a structured population-based program to achieve the goal of eliminating cervical cancer.
Published: 2024
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20. Corticosteroids for improving patient-relevant outcomes in HELLP syndrome: a systematic review and meta-analysis

Author: Asmaa F. Kasem, Hamdy B. Alqenawy, Marwa A. Elgendi, Radwa R. Ali, Rania HM Ahmed, Mohammad N. Sorour, Khadiga MH Hegab, Rania G. El-skaan, Rowyna H. El Helw, Mohamed S. Elsewefy, Maya M. Abdelrazek, Yasser M. Elrefaey, Mohamed YG Albahaie, Mohamed H. Salama, and Ashraf F. Nabhan
Subjects: HELLP syndrome, Corticosteroids, Maternal death, Perinatal death, Platelet transfusion, Pulmonary edema, Gynecology and obstetrics, RG1-991
Abstract: Abstract Background We conducted this updated systematic review to assess the effects of corticosteroids vs. placebo or no treatment for improving patient-relevant outcomes in hemolysis, elevated liver enzymes and low platelets (HELLP) syndrome. Methods CENTRAL, MEDLINE/PubMed, Web of Science, and Scopus, from the date of inception of the databases to February 3, 2024 were searched. Reference lists of included studies and systematic reviews were thoroughly searched. We included RCTs that enrolled women with HELLP syndrome, whether antepartum or postpartum, to receive any corticosteroid versus placebo or no treatment. No language or publication date restrictions were made. We used a dual independent approach for screening titles and abstracts, full text screening, and data extraction. Risk of bias was assessed in the included studies using Cochrane’s RoB 2 tool. Pairwise meta-analyses were conducted, where two or more studies met methodological criteria for inclusion. GRADE approach was used to assess certainty of evidence for the pre-specified outcomes. Results Fifteen trials (821 women) compared corticosteroids with placebo or no treatment. The effect of corticosteroids is uncertain for the primary outcome i.e., maternal death (risk ratio [RR] 0.77, 95% confidence interval [CI] 0.25 to 2.38, very low certainty evidence). Out of 6 studies reporting maternal death, 5 were judged overall to have “low risk” of bias. The effect of corticosteroids is also uncertain for other important outcomes including pulmonary edema (RR 0.70, 95% CI 0.23 to 2.09), dialysis (RR 3, 95% CI 0.13 to 70.78), liver morbidity (hematoma, rupture, and failure; RR 0.22, 95% CI 0.03 to 1.83), or perinatal death (0.64, 95% CI 0.21 to 1.97) because of very low certainty evidence. Low certainty evidence suggests that corticosteroids have little or no effect on the need for platelet transfusion (RR 0.98, 95% CI 0.60 to 1.60) and may result in a slight reduction in acute renal failure (RR 0.67, 95% CI 0.40 to 1.12). Subgroup and sensitivity analyses showed results that were similar to the primary synthesis. Conclusions In women with HELLP syndrome, the effect of corticosteroids vs. placebo or no treatment is uncertain for patient-relevant outcomes including maternal death, maternal morbidity, and perinatal death. These uncertainties regarding this critical question should be addressed by adequately powered rigorous trials. Systematic review registration Center for Open Science, osf.io/yzku5.
Published: 2024
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21. A study of the effect of industrial and natural wastes on cement mortar properties

Author: Abdulkarem, Mais A., Rasool, Dalia Adil, and Nabhan, Baydaa Jaber
Published: 2024
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22. Introduction: The Union of Coyote Iguana and Lola Casanova Set in a Time of Crisis

Author: Nabhan, Gary Paul
Published: 2024
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23. How Good Is Oral History and What Is It Good For?

Author: Nabhan, Gary Paul and Monti, Laura
Published: 2024
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24. Account Given by Manuel Monroy of Jesús Ávila Sánchez, Dolores Casanova Villegas, and Victor Ávila Casanova

Author: Nabhan, Gary Paul and Monti, Laura
Published: 2024
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25. The Oral Histories of Coyote Iguana and Dolores Casanova Among the Comcaac

Author: Mellado, Alberto and Nabhan, Gary Paul
Published: 2024
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26. Sedimentological and Geomorphological Characteristics of Jabal Kudumbul Island, Southeast Red Sea, Saudi Arabia

Author: Nabhan, Abdullah, Widinly, Nawaf, Memesh, Abdullah, Khorsheed, Mustafa, El-Sorogy, Abdelbaset S., and Tawfik, Mohamed
Published: 2023

27. THE NUMBER OF EXTRANODAL SITES IN NODAL PTCL: A PROPOSAL FOR A FEASIBLE PROGNOSTIC MARKER FOR OUTCOMES IN LOW-INCOME COUNTRIES. A COLLABORATIVE STUDY GRUPO DE ESTUDIO LATINO-AMERICANO DE LINFOPROLIFERATIVO (GELL) & T-CELL BRAZIL PROJECT (TCBP)

Author: T Fischer, E Miranda, J Pereira, G Duffles, JV Tavares, NS Castro, RSA Silva, DLC Farias, SAB Brasil, CCG Macedo, C Colaço, RLR Baptista, KZ Cecyn, D Bortucchi, GFS Barros, S Nabhan, PPG Radtke, R Schaffel, N Zing, FL Nogueira, AD Cunha-Junior, DV Clé, JTDS Filho, VLP Figueiredo, MD Pont, R Gaiolla, N Hamerschlak, EFO Ribeiro, A Hallack-Neto, MA Dias, Y Gonzaga, YS Rabelo, L Teixeira, G Perini, MALHM Conhalato, P Cury, H Idrobo, D Castro, B Beltran, D Enriquez, J Vasquez, C Roche, D Artiles, F Valvert, L Villela, C Oliver, L Korin, C Pena, M Roa, MAT Viera, AV Gasenapp, A Quiroz, CS Figari, R Rios, S Paredes, EE Saul, C Bermack, K Meza, B Valcarcel, CA Souza, L Malpica, and CS Chiattone
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introduction: PTCL accounts for 10-15% of all NHL. As previously demonstrated, Latin America has its own epidemiological distribution, with a high frequency of ATLL and ENKT, likely influenced by distinct genetic profiles and viral epidemiology. 3-year OS is about 40%. Treatment advances have also been limited, except for BV-CHP in some countries. The IPI, which includes extranodal (EN) site as a variable, has been validated for PTCL. However, the specific impact of EN involvement on nodal PTCL (such as PTCL-NOS, AIT, ALCL ALK+/ALK-) and its biological implications remain unclear. Simplification could improve the reproducibility and applicability of these models, especially in low-income countries. Objective: To evaluate number of EN sites in nodal PTCL lymphomas as a risk factors or surrogate for outcomes, as OS and PFS in Latin America cohort. Methodology: Patients (pts) aged ≥18 years with newly diagnosed nodal PTCL-NOS, AITL and ALCL ALK+/ALK-) from GELL (n = 339, 2000-2023, retrospective), TCBP (n = 427, 2015-2022, ambispective). Treatment outcome was determined by OS and PFS. REDcap Platform (by Vanderbilt) was used to collect and store data, whereas statistical analysis the IBM-SPSS v.24. This trial is registered at Clinical trials (NCT03207789). Results: 766 pts [427pts - TCBP and 339 - GELL] diagnosed with nodal PTCL were grouped according to the number of EN: no EN involvement (No EN - 383); one EN involvement (EN1 -168); and 32 (EN2 - 215). Considering all, 61% male; median age 56 y/o; 74% were staged III/IV; 69% IPI 32; 60% was PTCL-NOS, 19% ALCL ALK- and 12% AITL. 61% had B symptoms and 55% elevated LDH. CHOEP was used in 47% and 34% CHOP, and 47% achieved CR after first line; 16% used transplant as consolidation. No EN, EN1 and EN2 were similar regarding clinical characteristics, except, for stage III/IV (58% vs. 79% vs 96%; p < .0001); IPI 32 (58% vs. 59% vs. 99%; p < .0001); ECOG>1 (58% vs. 92% vs. 99%; p < .0001); BMO involvement (16% vs. 24% vs. 63%%; p
Published: 2024
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28. SARCOMA DE KAPOSI, SÍNDROME DE CASTLEMAN MULTICÊNTRICA E LINFOMA DIFUSO DE GRANDES CÉLULAS B RELACIONADOS AO HHV-8: UM DESAFIO CLÍNICO

Author: JC Faccin, FF Campos, CC Miranda, IS Barbosa, ACB Edir, GRO Medeiros, I Menezes, PZ Rebutini, and SK Nabhan
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: As doenças causadas pela infecção pelo HHV-8 incluem, além do sarcoma de Kaposi, um espectro de doenças linfoproliferativas que afetam especialmente pacientes HIV. Geralmente, resultam da interação entre o vírus e um sistema imune desregulado, formando nichos inflamatórios nos quais as células B, em diferentes estágios de desenvolvimento, são infectadas, proliferam e podem passar de um estado policlonalpara monoclonal/neoplásico. Objetivo: Reportar um caso que envolve o espectro de doenças linfoproliferativas associadas ao HHV-8 em paciente diagnóstico recente de HIV em fase AIDS. Relato de caso: Homem de 34 anos, com diagnóstico de HIV recente, em uso de terapia antirretroviral há 1 mês, é encaminhado para investigação de quadro febril e bicitopenia (anemia normocítica normocrômica e plaquetopenia, ambas com requerimento transfusional). À admissão, apresentava linfonodos aumentados em número em cadeias cervicais, axilares e inguinais, hepatoesplenomegalia e manchas amarronzadas, irregulares e assintomáticas em membros inferiores. Demais exames laboratoriais alterados: hiponatremia, hipoalbuminemia e provas inflamatórias elevadas. As tomografias evidenciaram derrame pleural moderado bilateral e ascite pequena, ambos negativos para malignidade. Biópsias da lesão cutânea e de linfonodo com alterações morfológicas sugestivas de doença associada à infecção pelo HHV-8, manifestação cutânea compatível com Sarcoma de Kaposi e linfonodo compatível com Doença de Castleman Multicêntrica (DCM). A medula óssea continha apenas alterações reativas e a investigação foi ampliada com endoscopia e colonoscopia. Foi identificada lesão em corpo gástrico compatível com neoplasia de células linfoides de morfologia centroblástica e plasmablástica, com expressão de CD30, MUM-1 e Ki67 de 95%, também positiva para o HHV-8 compatível com o diagnóstico de um Linfoma Difuso de Grandes Células B associado ao HHV-8 (HHV-8 + LDGCB NOS). O paciente iniciou tratamento com quimioterapia (CHOP) e manteve a terapia antirretroviral com melhora clínica exuberante e resolução das citopenias ainda no 1° ciclo. Ao término do 6° ciclo, apresentou resposta metabólica completa bem como resolução das lesões do Kaposi. Discussão: A DCM é uma hiperplasia angiofolicular que leva à proliferação clonal de células B e tem as características histopatológicas presentes em mais de uma porção do linfonodo. Apresenta curso clínico com exacerbações intermitentes e 50% dos casos são positivos para HHV-8, diferindo em tratamento e prognóstico. Poucos casos de HHV-8 + LDGCB NOS ocorrem na ausência de DCM concomitante. Nesta entidade, os plasmablastos neoplásicos formam folhas e aglomerados confluentes que destroem a arquitetura do tecido subjacente e confere um prognóstico pior. No entanto, o número limitado de casos relatados dificulta a definição de uma terapia ideal. Conclusão: Relatamos o caso raro de um paciente com diagnóstico de três neoplasias sincrônicas associadas ao HHV-8, tratado com poliquimioterapia e desfecho favorável.
Published: 2024
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29. LINFOMA DE CÉLULAS DO MANTO POSITIVO PARA CICLINA D1 CRÍPTICA ATÍPICA: UM RELATO DE CASO

Author: JC Faccin, FB Patricio, CC Miranda, IS Barbosa, ACB Edir, T Borgonovo, LW Merfort, GMO Rosendo, AP Azambuja, and SK Nabhan
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: O linfoma de células do manto (LCM) representa 5% de todos os linfomas não-Hodgkin e o seu diagnóstico requer a integração entre morfologia e imunofenótipo apoiada pela superexpressão da ciclina D1 através da t(11; 14)(q13; q32) em 95% dos casos. Apesar disso, a superexpressão de ciclina D1 pode ocorrer sem rearranjo gênico detectado por citogenética ou FISH. Objetivo: Reforçar a possibilidade do diagnóstico de LCM na ausência do rearranjo gênico clássico. Relato de caso: Masculino de 70 anos, hipertenso bem controlado, encaminhado para a hematologia, assintomático, por bicitopenia discreta (anemia normocítica e normocrômica normoproliferativa e plaquetopenia) além de leucocitose às custas de células de aspecto imaturo com características linfoides. À admissão, apresentou-se com linfonodomegalias pequenas em cadeia cervical, axilar e inguinal bem como hepatoesplenomegalia pequena. O hemograma tinha hemoglobina de 11,2, leucócitos de 15.300 com 64% de células de características linfoides e plaquetas de 123.000. As tomografias evidenciaram linfonodomegalias em tórax, abdome e pelve, algumas formando conglomerados (a maior na cadeia para-aórtica esquerda, de 43 mm) além de nódulos não calcificados no lobo inferior direito suspeitos para lesões de natureza neoplásica. A biópsia do linfonodo cervical identificou proliferação de linfócitos B, CD5+ e com superexpressão de ciclina D1 além de Ki67 de 40 a 50%, compatível com LCM. A medula óssea estava infiltrada pelas mesmas células, mas o cariótipo apresentava 36̃45,XY,+mar(4)/46,XY(16) e o FISH para t(11;14) e 17p era negativo. Discussão: Dentre os casos de LCM a t(11; 14)(q13; q32) é identificada por citogenética convencional e FISH ematé 75% e entre 80 e 100% dos casos, respectivamente. Embora a ausência do rearranjo gênico detectado por citogenética ou FISH questione o diagnóstico de LCM, outros fatores podem justificar a superexpressão da ciclina D1 como erros técnicos na realização do exame, mosaicismo baixo, outras alterações citogenéticas incluindo translocações crípticas (principalmente em casos com cromossomo marcador). A justaposição do gene da cadeia pesada de imunoglobulina com o gene da ciclina D1 ativa quinases dependentes de ciclina que fosforilam e superam efeitos inibitórios do ciclo celular corroborando para a proliferação das células. Dentre as alterações citogenéticas alternativas estão: t(2;11)(p11;q13), t(11;22)(q13;q11.2), t(6;14)(p21.2;q32), ins(14;11)(q32,q13q13), t(11:19,14)(q13;q13;q32), t(14;16)(q32;q23), t(14;20)(q32;q12), t(1;11;14)(q32;q13;q32), t(3;14;11)(q21;q32;q13) e t(4;14) (16;q32). Conclusão: Relatamos o caso raro de um paciente com diagnóstico de LCM sem rearranjo gênico clássico detectado por citogenética ou FISH, mas com superexpressão da ciclina D1 possivelmente justificada por translocação críptica visto presença de marcador (resultante de alterações estruturais de origem indefinida).
Published: 2024
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30. ANÁLISE PROGNÓSTICA DA LEUCEMIA LINFOCÍTICA CRÔNICA: CORRELAÇÃO ENTRE ALTERAÇÕES CROMOSSÔMICAS DETECTADAS POR FISH E ESTADIAMENTO CLÍNICO EM PACIENTES DE UM HOSPITAL DA REDE SUS

Author: I Barbosa, ACB Edir, R Romano, CC Miranda, JC Faccin, L Merfort, VR Jamur, SK Nabhan, T Borgonovo, and AP Azambuja
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: A Leucemia Linfocítica Crônica (LLC) é uma doença caracterizada por heterogeneidade biológica e clínica significativa. Enquanto a maioria dos pacientes apresenta um curso indolente, alguns podem apresentar manifestações mais agressivas, com resistência ao tratamento e redução na sobrevida. Objetivo: Identificar alterações cromossômicas detectadas por hibridização in situ por fluorescência (FISH) em pacientes com diagnóstico de LLC e correlacioná-las com o prognóstico da doença. Métodos: Análise retrospectiva de pacientes com diagnóstico de LLC acompanhados ambulatoriamente no Hospital das Clínicas da UFPR, entre janeiro de 2006 e junho de 2024. Utilizou-se a análise cromossômica por bandeamento gênico convencional e o protocolo FISH em células fixadas de sangue periférico, conforme as instruções do fabricante. O painel utilizado foi o Vysis CLL FISH probe (Abbott, USA), que inclui quatro sondas: LSI ATM (11q22.3), LSI TP53 (17p13.1), CEP12 (12p11.1-q11), LSI D13S319 (13q14.3) e LSI 13q34. Os laudos foram elaborados de acordo com a nomenclatura internacional (ISCN, 2016). Resultado: 55 pacientes com LLC, 31M/23F, idade mediana de 65,4 anos (variando de 24 a 92 anos) e tempo mediano de acompanhamento de 4,8 anos (de 0,15 a 27 anos) foram avaliados. Os pacientes foram classificados segundo os critérios do hemograma em Binet A (31 pacientes), Binet B (10 pacientes) e Binet C (13 pacientes). Houve diferenças significativas na dosagem de hemoglobina, contagem de plaquetas e leucócitos entre os grupos (p < 0,05). A citometria de fluxo revelou um padrão típico de marcação de antígenos de membrana (CD5, CD23 e CD200 positivos; CD22, CD79a, IgM e FMC7 negativos ou com baixa expressão) em todos os pacientes. A citogenética convencional foi realizada em 24 pacientes (43,6%), dos quais 6 apresentaram alterações cromossômicas. O exame FISH detectou alterações em 48 pacientes (87,3%): 37 (67,3%) com deleção do cromossomo 13; 12 (21,8%) com trissomia do cromossomo 12; sete (12,7%) com del14 e 6 pacientes (10,9%) com deleção 11q (ATM). Apenas 4 pacientes (7,3%) apresentaram deleção 17p, e 13 pacientes tiveram mais de uma alteração cromossômica identificada pelo FISH. Durante o acompanhamento, ocorreram 20 óbitos (36,3%), sendo 8 no grupo Binet A (25,8%), 4 no Binet B (40,0%) e 8 no Binet C (61,5%). Os óbitos foram associados a trissomia 12 (6 casos), perda do ATM (5 casos), deleção 17p (4 casos) e deleção isolada do 13q (7 casos). Uma paciente com deleção 13q e 11q associadas desenvolveu a Síndrome de Richter. A sobrevida global mediana foi de 12,4 anos nesta coorte, com diferença entre os grupos de risco citogenético: 12,4 anos no grupo com del 13q; 4,25 anos nos pacientes com trissomia do 12 e apenas 4,4 anos no grupo conjunto del11q e del17p, p < 0,05. Pacientes sem alterações citogenéticas ou no FISH parecem ter sobrevida semelhante aos grupos de pior prognóstico (4,92 anos). Não houve diferença na sobrevida mediana entre os grupos Binet: 11.4 anos Binet A; 10.0 Binet B e 5.9 no Binet C (p = 0,56). Discussão: O percentual de pacientes com deleções 11q e 17p e trissomia do 12 estão alinhados com a literatura atual sobre alterações genéticas na LLC. No entanto, a prevalência da deleção 13q na nossa coorte foi de 67,3%, significativamente maior do que os 35% reportados na literatura. Essa discrepância pode ser atribuída ao perfil temporal da nossa coorte. Apesar disso, a estratificação prognóstica realizada por FISH demonstrou ser valiosa para a caracterização dos pacientes, enquanto o estadiamento de Binet parece não ter relevância significativa no contexto local, especialmente considerando que os tratamentos utilizados não incluíram terapias direcionadas.
Published: 2024
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31. IMPACTO DA RECAÍDA E PERFIL MUTACIONAL NA SOBREVIDA DE PACIENTES COM LEUCEMIA MIELÓIDE CRÔNICA (LMC) EXPOSTOS A INIBIDORES DE TIROSINO QUINASE (ITQ) E SUBMETIDOS A TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOIÉTICAS (TCTH): UMA ANÁLISE DE LONGO PRAZO

Author: VAM Funke, GRO Medeiros, ACM Lima, ALV Mion, I Menezes, DC Setubal, CBDS Sola, R Marchesini, SK Nabhan, and R Pasquini
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: O TCTH alogênico continua a ser considerado a terapia padrão para pacientes com LMC refratária aos Inibidores de Tirosina Quinase (ITQs). No entanto, os desfechos pós transplante, incluindo os fatores de risco para recaída e o comportamento das mutações nesses pacientes, permanecem sendo um ponto de debate na literatura. Objetivo: Avaliar o perfil mutacional pré e pós transplante e as demais variáveis que influenciaram o desfecho de recaída, em uma coorte de pacientes submetidos a TCTH após exposição aos ITQs. Métodos: Estudo retrospectivo, observacional e analítico, realizado a partir de registros de dados. Foram avaliados 70 pacientes com diagnóstico de LMC que haviam recebido tratamento prévio com ITQ, e foram transplantados no período de 2001 a 2021, sendo identificados 27 pacientes que recaíram após o transplante. Para análise estática, foram utilizadas curvas de incidência cumulativa e o Teste de Gray na análise univariada e regressão de Fine-Gray na análise multivariada para incidência de recaída. A análise comparativa entre as curvas de sobrevida foi realizada através do Log-Rank Test. Resultados: Nesta coorte, a incidência cumulativa de recidiva foi de 27,1% em 1 ano (17,3%‒38%) e 38,9% em 5 anos (27,3%‒50,3%). A única variável associada ao risco de recidiva foi o uso de sangue periférico como fonte de células (SHR 2,85; 1,27‒6,36). No entanto, esses dados devem ser interpretados com cautela, pois a maioria dos pacientes estavam em estágios avançados de doença. Dos 27 pacientes que recaíram, a maioria teve recaída molecular (14), 3 tiveram recaída citogenética e 6 recaída hematológica, sendo que 4 tiveram falha do enxerto. Dos pacientes em recaída hematológica, 2 estavam em fase acelerada e 4 em crise blastica. Quanto à terapia após recaída, 7 receberam Infusão de Linfócitos do Doador (ILD), 17 utilizaram ITQs e 6 pacientes utilizaram ambos. Cinco pacientes alcançaram remissão molecular sustentada após ITQ/ILD. Dos 19 pacientes com mutações pré-transplante, apenas 4 tinham mutações na recaída; 2 deles apresentaram novas mutações. Dos 6 pacientes com mutação T315I antes do TCTH, apenas 1 paciente permaneceu com a mutação na recaída, 1 paciente apresentou E255K e 4 não tinham mutação. Até o último follow-up, 15 pacientes haviam falecido (55%), principalmente devido à progressão da doença. Entre os 12 pacientes vivos (45%), 3 tinham leucemia molecularmente indetectável, 1 alcançou RM 4.5, 2 alcançaram RM 4.0, 2 alcançaram RMM, 3 alcançaram CCyR e um estava em MCyR. A sobrevida global (SG) estimada em 5 anos do grupo que recaiu foi de 50%, em 10 anos de 40% e em 20 anos de 25%. A mediana de sobrevida foi de 2001 dias versus não atingida para o grupo dos pacientes em remissão. Conclusão: Este estudo de seguimento de 20 anos relata resultados a longo prazo do TCTH na LMC após falha aos ITQs. Descrevemos uma incidência cumulativa de recaída de 38,9% em 5 anos e observamos o impacto negativo da recaída na sobrevida global destes pacientes, sugerindo que estratégias para evitar este evento (manutenção com ITQ? ILD profilático?) devem ser testadas. Quanto ao perfil mutacional, houve um padrão diferente de mutações na recaída, sugerindo que elas devem ser sempre reavaliadas.
Published: 2024
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32. RELATO DE TRANSPLANTE AUTÓLOGO PARA LINFOMA DE CÉLULAS DO MANTO EM PACIENTE OBESO MÓRBIDO COM MÚLTIPLAS COMORBIDADES

Author: JP Resende, FB Patricio, CB Sola, G Tagliari, R Marchesini, D Csetubal, M Cuollo, S Nabhan, and VAM Funke
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Introdução: O tratamento do Linfoma de Células do Manto é desafiador. No cenário do SUS, traz um desafio maior devido às limitações das opções terapêuticas, nesse contexto o transplante autólogo se torna imprescindível. Objetivos: Relatar a experiência do transplante autólogo no paciente com obesidade mórbida e com múltiplas comorbidades. Materiais e métodos: Revisão de prontuário sem identificação da paciente. Relato de caso: Paciente sexo masculino, 52 anos, casado, natural e procedente de Curitiba-PR. Em setembro de 2023 evoluiu com linfonodomegalia em região cervical, associado a febre e sudorese noturna . Negava perda ponderal. Realizou biópsia de linfonodo supraclavicular direito que confirmou diagnóstico de Linfoma de Células do Manto com MIPI score de alto risco. Os antecedentes patológicos do paciente incluíam Flutter atrial, síndrome metabólica (HAS, DM2, Hipertrigliceridemia) e obesidade mórbida (IMC > 40). Devido às múltiplas comorbidades foi proposto um tratamento quimioterápico menos intensivo, o R-CHOP. Após seis ciclos do R-CHOP, foi feito reestadiamento com PET-CT em maio de 2024, que mostrava resposta completa, Deauville 2. Diante desse cenário de resposta completa, foi encaminhado para o serviço de Transplante de Medula óssea, com objetivo de consolidar o tratamento com transplante autólogo, seguido de manutenção com rituximabe. Nesse contexto, foi optado por um condicionamento alternativo ao BuCyE, sendo escolhido o BuFlu (Bussufalno 9,6 mg/kg e Fludarabina 150 mg/m2). As doses de quimioterapia foram corrigidas para o peso ideal ajustado do paciente. Durante internamento paciente apresentou pouca toxicidade, mucosite grau II sem impacto na alimentação e não apresentou neutropenia febril no internamento. Apresentou pega neutrofílica e plaquetária no D+13 com boa evolução no seguimento. Discussão: A escolha do condicionamento é um dos pilares para o transplante. A individualização do mesmo deve levar em consideração o diagnóstico hematológico, o status da doença, status performance de cada paciente, além das comorbidades pregressas. Na atualidade, a obesidade vem comprometendo uma parcela significativa da população. Junto a isso, inúmeros estudos vêm demonstrando piores desfechos do tratamento de doenças oncológicas na população obesa. O impacto negativo da obesidade sobre o desfecho do transplante de medula óssea, sobretudo no transplante alogênico, é frequentemente descrito na literatura. Além do mais, a compreensão do impacto sobre a farmacocinética dos quimioterápicos ainda é muito limitada, especialmente nas doses empregadas nos condicionamentos. Acredita-se que a depuração dos fármacos nesta população é mais lenta, desse modo, algumas recomendações existem, mas não são unânimes na literatura para algumas drogas. Para o bussulfano, por exemplo, a correção para o peso ideal ajustado é indicada, bem como a monitorização dos níveis séricos da droga. Já para a fludarabina, as recomendações na literatura são conflitantes, alguns autores recomendam o uso da dose pelo peso real do paciente, enquanto outros recomendam a correção para o peso ideal. Diante disso, o objetivo deste relato é trazer à luz a discussão e desafio de adaptar o regime de condicionamento para população com obesidade mórbida especialmente diante da falta de solidez em alguns dados na literatura e reforçar a necessidade de mais estudos que norteiem as condutas do manejo da população obesa no TMO.
Published: 2024
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33. Judicial Review of Congressional Power to Tax under U.S. Constitution: Tensions between Framers’ Intent and Imperatives of Reality

Author: Jawad Nabhan Salman
Subjects: Separation of Powers, Taxing Power, Taxation Clauses, Taxable Income, Checks and Balances, Law, Islamic law, KBP1-4860
Abstract: This paper discusses authority granted to Congress over imposing federal taxes in general, and income tax in specific. The author used the critical analytical method to analyze the rulings of the U.S. Supreme Court, the U.S. Income Tax Law, and the U.S. Constitution, to reach the policy followed by the court in ruling on the constitutionality of legal provisions related to the constitutionality of such tax legislations. The importance of this article comes in that it is one of the few studies that analyzed and criticized the policy of the U.S. Supreme Court in its ruling on the constitutionality of tax federal legislations. The author explains the role of the U.S. Supreme Court in identifying what is considered as income in some gray areas that the U.S. tax code (26 U.S. Code of 1986) did not provide an answer for, or petitioners claimed that such income does not fall in gross income inclusions. In addition, the author explains the philosophy behind granting Congress such power, and the effects of such authority. Although the author believes that many amendments to the tax code has political backgrounds rather than economic, granting this power to Congress would be less arbitrary compared to the political scenarios that could appear if it granted to the Executive Branch. At last, the author discusses the constitutional limits on congressional power of taxing and how these limits would affect tax legislations that Congress was trying to pass, considering people’s right of equity in tax treatment under Uniformity Clause.
Published: 2024
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34. They Call You Back: A Lost History, a Search, a Memoir by Tim Z. Hernandez (review)

Author: Nabhan, Gary Paul
Published: 2024
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35. Utilizing cellulose nanofibers to enhance spent engine oil performance: A sustainable environmental solution

Author: Mohamed Taha, Hamouda M. Mousa, Husain Alfadhel, Emad Abouel Nasr, A.H. Abdelbaky Elbatran, Ahmed Nabhan, and Mohamed R. El-Sharkawy
Subjects: Recycling, Used engine oil, Cellulose nanofiber, Lubricant, sustainable environment, Technology
Abstract: Spent engine oil is a major source of environmental pollution that affects the aquatic ecosystem and human health. Cellulose nanofibers (CNF) are natural nanomaterials that can be used as additives in spent engine oil to enhance its performance, especially at high temperatures and pressures. Utilizing sulfur-based unbleached rice straw pulping technique, the rice straw was grinded in a solution with 10 % sodium sulfite and 2 % sodium carbonate, that heated to 160 °C for 2 h. This produces unbleached sulfur pulp, which is then analyzed for ash, cellulose, and lignin content. A subsequent bleaching step at 80 °C with a sodium chlorite/acetic acid mix completes the process. This technique was adopted to produce CNF. In this study, preparation and characteriztion of CNF-additives to spent engine oil was performed using different techniquessuch as; IR spectra analysis, kinematic viscosity, and wear scar width. It was also evaluated on the oil adsorption, vibration, and noise reduction properties of the resulted additive oil. The results showed that CNF improved viscosity, lubrication, and anti-wear properties of the oil, and decreased its friction, vibration, and noise. The optimal concentration of CNF was 2.0 wt%, which increased the kinematic viscosity by 14.5 % and reduced the wear scar width by 31 % compared to the spent oil sample. Moreovere, CNF reduced the environmental impact of oil disposal and recycling. Overall, CNF are promising nanofillers for improving the performance of spent engine oil and lowering its environmental impact.
Published: 2024
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36. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries

Author: Dönmez, A Eylül, Goswami, Aakansha Giri, Raheja, Aashna, Bhadani, Aayush, El Kady, Abd Elrahman Safwat, Alniemi, Abdalaziz, Awad, Abdalkarim, Aladl, Abdalla, Younis, Abdalla, Alwali, Abdallah, Khalil, Abdallah, Mansour, Abdallah, Elkhouly, Abdallah Mohamed, Rashad Temerik, Abdallah, Hasan, Abdallatef, Chied, Abdelhafid, Abdraba, Abdelhamid, Hrora, Abdelmalek, Abdelshafi, Abdelrahman, Alwali, Abdelrahman, Maraqa, Abdelrahman, Ghaffar, Abdul, Chekfa, Abdul Jabar, Al Balushi, Abdul Majeed, Quddus, Abdul, Hammadieh, Abdul Rahman, Muntaka, Abdul-Jalilu Mohammed, Asekun, Abdulazeez, Alshahrani, Abdulaziz, Jowharji, Abdulaziz, Alshukre, Abdulbaset, Khair Etareig, Abdulhafid, Abubakar Abdulkarim, Abdulhafiz, Ashiru, Abdulhafiz, Alailesh, Abdulhamid, Al-Mallah, Abdullah, Baydoun, Abdullah, Chaudhry, Abdullah, Askin, Abdullah Emre, Almutairi, Abdulmjeed, Belkhair, Abdulmunem, Abdllah, Abdulrahman, Alhammali, Abdulrahman, Basalim, Abdulrahman, Abouelnagah, Abdulrahman Galal Mohamed Mostafa, Ghazal, Abdulrahman, Mohammed, Abdulrahman, Qasem, Abdulrahman, Anadani, Abdulrazak, Jimoh, Abdulrazaq, Lawal, Abdulrazzaq Oluwagbemiga, Khaity, Abdulrhman, Lawal, Abdulwahab, Elzoubi, Abdurrahim Esseid, Sheshe, Abdurrahman Abba, Cetişli, Abdurrahman Furkan, Oyedele, Abeeb, Aljahdali, Abeer, Aboelnasr, Abeer Gamal Elsyed, Demessie, Abel, Bhargava, Abhilasha, Sonkar, Abhinav Arun, Bavaharan, Abhirame, Khan, Abid, Campbell, Abigail, Oyelekan, Abimbola Adeola Akintunde, Okunlola, Abiodun Idowu, Ojewuyi, Abiodun, Ekerin, Abiola, Saleh, Abobakr, Khairy, Abouelatta, Muthunayagam, Abraham Benjamin, Botha, Abraham, Teshome Sahilemariam, Abraham, Nawawi, Abrar, Muhammad, Abubakar Bala, Dahiru, Abubakar, Yahaya, Abubakar, Abdelmalik, Abubaker, Anuar, Abul Akmal Arif, Ousseini, Adakal, Leon -Del- Angel, Adalberto, Frankel, Adam, Gyedu, Adam, Lim, Adam, Lukáč, Adam, Peckham-Cooper, Adam, Sabbah, Adam, Varga, Adam, Sanou, Adama, Issaka, Adamu, Ningi, Adamu, Yeshitila, Addis, Yingess, Addisu, Olugbami, Adebayo, Moses, Damola-Okesiji, Adebola, Lawal, Adedayo, Ojo, Adedoyin, Hashmi, Adeel, Fakoya, Adegbolahan, Ishola, Adegoke, Abiodun, Adekunle, Ajayi, Adekunle, Mouffokes, Adel, Bonelli, Adele, Adekoya, Adeleke, Akeem Aderogba, Adeleke, Özcan, Adem, Ayoade, Ademidun, Adeyeye, Ademola, Agbaje, Ademola, Talabi, Ademola, Ademuyiwa, Adesoji, Adewumiya, Adesoji, Ademuyiwa, Adesoji O, Aderounmu, Adewale, Adisa, Adewale, Oke, Adewale, Ragab, Adham, Alzadjali, Adil, Baksi, Aditya, Jayapalan, Aditya, Md Yunos, Adnan, Pisanu, Adolfo, Salazar, Adolfo, Salinas Barragan, Adrian Alberto, Fox, Adrian, Stollberg, Adrian, Franco, Adriana, Neves, Adriana, Vricheva, Adriana, Hodonou, Adrien Montcho, Aghayeva, Afag, Liaquat, Affifa, Alsultan, Afnan, Morad, Afnan, Kalidis, Afroditi Angella, Gkouniaroudi, Agathi, Karakosta, Agathi, Lovi, Agbenya, Yevide, Agossou Barthélémy, Duro, Agustin, Rodriguez Gonzalez, Agustin, Tariq, Ahbala, Abaidalla, Ahmad, Abuhammad, Ahmad, Abuhantash, Ahmad, Mansour, Ahmad Adel, Ahmad Zaidi, Ahmad Al Hafeez, Alahmad Alismael, Ahmad, Alayed, Ahmad, Alfarwan, Ahmad, Alhaj, Ahmad, Ali, Ahmad, Alroobi, Ahmad, Alsheikh, Ahmad, Alusef, Ahmad, Alzu'Bi, Ahmad, Kayali, Ahmad Amir, Bouhuwaish, Ahmad, Doghaim, Ahmad, El-Sherbiney, Ahmad, Ghazal, Ahmad, Ramly, Ahmad Nasir, Raza, Ahmad, Qureshi, Ahmad Uzair, Arnaout, Ahmad Yamen, Abdelhamid, Ahmed, Abuthaher, Ahmed, Adel, Ahmed, Ahmayda, Ahmed, Al-Mouahhed, Ahmed, Alagha, Ahmed, Albalawi, Ahmed, Albhaisi, Ahmed, Alrifaee, Ahmed, Azam, Ahmed, Barakat, Ahmed, Al-Hajjaj, Ahmed Basim Abed, Dawoud, Ahmed, El Shamarka, Ahmed, El-Bastwesy, Ahmed, Elghrieb, Ahmed, Elkhalifa, Ahmed, Elmosalamy, Ahmed, Elshazli Mahmoud, Ahmed, Montaser, Ahmed G., Gbeadese, Ahmed, Haty, Ahmed, K. 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Daniel, Montwedi, Daniel, Muñoz, Daniel, Patterson, Daniel, Reim, Daniel, Agbley, Daniel Yao Dodzie, Patiño García, Daniela Cristina, Di Pietrantonio, Daniela, Pais, Daniela, Rosado, Daniela, Tavares, Daniela, Alberti, Daniele, Fusario, Daniele, Massaro, Daniele, Paglione, Daniele, Pironi, Daniele, Kurochka, Daniil, Centonze, Danilo Corrado, Hackner, Danilo, Herrera, Danilo, Amangaliyev, Daniyar, Silva-Cano, Danny Wladimir, Chaudhry, Daoud, Palmisano, Dario, Ribero, Dario, Vukosav, Dario, Misca, Darius, Lowen, Darren, Rattray, Darren, Walia, Darshanjit Singh, Maan, Darvesh, Muyenzi, Daryle, Verdi, Daunia, Bardsley, David, Reyes Rodríguez, David Estuardo, Fra Corral, David, Garcia López De Goicoechea, David, Gavit, David, Gómez, David, Idowu, David, Konkin, David, Labadah, David Kplorla Kekeli, Liu, David, Merlini, David, Mitchell, David, Moro-Valdezate, David, Osifo, David, Proud, David, Ridder, David, Gobatti, Davide, Muschitiello, Davide, Pertile, Davide, Zulian, Davide, Mengiste, Dawit, Mikami, Dean, Mohanty, Debajyoti, Chatterjee, Debarghya, Komolafe, Deborah Olaitan, Scotto Di Carlo, Deborah, Wright, Deborah, Rahme, Deema, Talreja, Deep Parkash, Jain, Deepak, Rajput, Deepak, Singh, Deepak, Anbu, Deepika, Ibrahim, Dena, Phom, Denchu, Hili, Denise, Osei, Dennis Broni, Daary, Dennis, Kyeremeh, Dennis, Shen, Dennis, Uymaz, Derya Salim, Cianflocca, Desiree, Ashitey, Desmond, Evripidou, Despo, Papageorgouli, Despoina, Kaushal, Devesh, Abeysirigunawardana, Dewmi, Dugar, Dharmendra, Mallik, Dhiraj, Ghosh, Dhruva, Houmran, Diaa, Abdulrahman, Diala, Pantoja Pachajoa, Diana Alejandra, Cardona Gomez, Diana Catalina, Fenner, Diana, Gonzalez, Diana Samantha, Siriwardena, Diana, Garcés Palacios, Diana Sofía, Stoian, Diana, Zuikyte, Diana, Sosa Méndez, Dianne Alitzá, Wickramarathna, Dickson, Mutter, Didier, Palma Portillo, Diego Andrés, Chavez Fernandez, Diego, Córdova García, Diego, Enjuto, Diego, Giulitti, Diego, Sasia, Diego, Visconti, Diego, Yiğit, Dilara, George, Dilip, Rabaia, Dima, Georgiev, Dimitar, Hadzhiev, Dimitar, Alexandrou, Dimitrios, Balalis, Dimitrios, Giakoustidis, Dimitrios, Manatakis, Dimitrios K., Korkolis, Dimitrios, Lytras, Dimitrios, Massaras, Dimitrios, Moris, Dimitrios, Politis, Dimitrios, Sampanis, Dimitrios, Schizas, Dimitrios, Tsiardas, Dimitrios, Vardakostas, Dimitrios, Kotsaris, Dimitris, Khattab, Dina Hesham, M. Awad, Dina, Alrokh, Dina Sami, Schippers, Dina, Waleed, Dina, Salinovic, Dinko, Gonçalves Múrias Gomes, Diogo Miguel, Silva, Diogo, Vaz Acosta, Diogo, Morton, Dion, Panagopoulos, Dionisios, Kelgiorgi, Dionysia, Dellaportas, Dionysios, Prevezanos, Dionysios, Joshi, Dipti, Ozal, Direm, Yigit, Direnc, Chimkaomasiri, Divine, Jabbar, Diya, Nepogodiev, Dmitri, Belekar, Dnyanesh, Abdalaziz, Doaa, Abunemer, Doaa, Attia, Doaa, Elkafrawy, Doaa, Dimitrov, Dobromir, Pignatelli, Domenica, Merlicco, Domenico, Soriero, Domenico, Zerbo, Domenico, Atouguia, Domingas, Fairbrass, Dominic, T. Enti, Donald, Venskutonis, Donatas, Rukavina, Dora, Caruso, Dorena, Herappe, Dorihela, Lee, Dorinda Norbetha, Ofosuhene, Doris, Hajela, Apoorva, Badwan, Basem, Kulkarni, Datta, Dhawan, Deep, Dhillon, Jeevanjit, Mehmood, Manzer, Mahmood, Namrah, Nikam, Narendra, Ramchandani, Radhakrishna, Thind, Ravinder Singh, Riazhussain, D Hafiz, Maqsood, Saliha, Alalawi, Yousef, Tyagi, Harshdeep, Kshirsagar, Shivani, Ahmed, Hisham, Juan Carlos, Luna Cydejko, Kone, Dramane, Omar, Duaa, Alves, Duarte Gil, Subasinghe, Duminda, Ommi, Durgesh, Joshiba, Durshney, Chakarov, Dzhevdet, Arkoh, Ebenezer Ameyaw, Frimpong-Manso, Ebenezer, Ada, Ece, Lincango, Eddy P., Lozada Hernandez, Edgard Efren, Hodžić, Edin, Di Marco, Edith, Baccalini, Edoardo Andrea, Baldini, Edoardo, González Marín, Eduardo, Gutierrez, Eduardo, Sepúlveda, Eduardo, Dainius, Edvinas, Zhang, Edward, Yenli, Edwin Mwintiereh Ta-Ang, Antoniou, Efstathios, Kapasakis, Efstathios, Baili, Efstratia, Poulios, Efthymios, Kubiliute, Egle, Osaze, Ehioghae, Afeikhena, Ehis, Elshennawy, Eiad, Athanasopoulou, Eirini, Synekidou, Eirini, Ekaladze, Eka, Tampaki, Ekaterini Christina, Adam, Elaf, Adel Hamdoun Aziz, Elaf, Yousuf, Elamin, Gialamas, Eleftherios, Spartalis, Eleftherios, Bedzhanyan, Elen, Toma, Elena Adelina, Daukšaitė, Elena, Desiato, Elena, Dvivedi, Elena, Hadzhieva, Elena, Martí Cuñat, Elena, Montalbán Martínez, Elena, Montanari, Elena, Signaroli, Elenasofia, Efremidou, Eleni, Gavriil, Eleni, Karakeke, Eleni, Mavrodimitraki, Eleni, Papamattheou, Eleni, Jose, Elenza, Cianci, Eleonora, Ciccioli, Eleonora, Daleva, Eleonora, Locci, Eleonora, Lori, Eleonora, Silanos, Eleonora, Ayala, Elí, Bankart, Eliana, Brolese, Eliane, Efstathiou, Elias, Salloum, Elias, Colak, Elif, Terzi, Elif Didem, Ametefe, Elikem, Cagigal Ortega, Elima Pilar, Donnarumma, Elio, Mina, Elisa, Reitano, Elisa, Wallner, Elisabeth, Moggia, Elisabetta, Betz, Elise, Kontis, Elissaios, Anestiadou, Elissavet, Gimson, Eliza, Lun, Elizabeth, Fraser, Elizabeth, Li, Elizabeth, Torres De Anda, Elizabeth Magaly, Murphy, Elizabeth Mary Ann, O'Connell, Elizabeth, Redondo, Elizabeth, Lun, Elizabeth Weng Yan, Francis, Ella, Haiden, Elmar, Hamed, Elmonzir, Alkhalifa, Elmustafa, Dexter, Eloise, Daketsey, Elorm, Setsoafia, Elorm, Mohamed, Elsagad, Mohammed, Elsamoual, Hegab, Elsayed, Ay, Elvin, Adinolfi, Elvira, Mbanzabugabo, Elvis, Chin, Elynn, Ahmed, Emad Ali, Younes, Eman, Basile, Emanuela, Gessa, Emanuela, Pontecorvi, Emanuele, Romairone, Emanuele, Hatangimana, Eméry, Ndizeye, Emile, Ciofic, Emilia, Dijan, Emilio, López-Negrete Cueto, Emilio, Baker, Emily, Reid, Emily, Schmidt, Emily, Alić, Emir, Bičakčić, Emir, Agbowada, Emma, Colton, Emma, Downing, Emma, Haege, Emma, O'Neill, Emma, Roussos, Emmanouel, Nachelleh, Emmanuel Aadereyir, Adebunmi, Emmanuel, Obiesie, Emmanuel Ahuizechukwu, Akakpo, Emmanuel Bismark, Konlan, Emmanuel Dammigu Francis, Nwangwu, Emmanuel Ifeanyi, Kafui Ayodeji, Emmanuel, Ofori, Emmanuel Owusu, Spanoudakis, Emmanuel, Abate, Emmanuele, Balik, Emre, Bozdağ, Emre, Bozkurt, Emre, Karabulut, Emre Cagri, Ozoran, Emre, Tunçcan, Emre, Tuzuner, Emre, Halilović, Emsad, Alabed, Enaam, Zidan, Enas, Hodžić, Enes, Aybar, Engin, Yildirim, Engin Okan, Wong, Enoch, Yhoshu, Enono, Bisogno, Enrica, Andolfi, Enrico, Ferri, Enrico, Potenza, Enrico, Spalice, Enrico, Volpin, Enrico, González, Enrique, Downes, Eoin, Gallo, Erdachew, Kamer, Erdinc, Naidoo, Eressa, Erginöz, Ergin, Bara, Eric, Irungu, Eric, García-Villegas, Eric Yusif, Mazzotta, Erica, Monati, Erica, Chan, Erick, Gómez Mejía, Erika, Dylja, Eris, Somuncu, Erkan, Yavuz, Erkan, Begunić, Ernes, Margelis, Ernest, Osei, Ernest Owusu, Saitoglou, Ertzan, Agastra, Ervis, Mazumdar, Eshan, Soyer Güldoğan, Esra, Abu Siam, Esra'A, Abdelbaset, Esraa, Abdu, Esraa, Adel Mahmod Sultan, Esraa, Nubi Mohamed, Esraa Gamal, Abuobaida Banaga Hag El Tayeb, Essam Eldien, Ali, Essraa, Page-Taylor, Estelle, Marra, Ester, Garcia Santos, Esther Pilar, Elsheikh, Ethar, Unal, Ethem, Tan, Eugene, De Leo, Eugenio, Borges, Eva, Gáspár, Éva, Ruiz-Daum, Eva, Apostolopoulos, Evaggelos, Samara, Evangelia, Barkolias, Evangelos, Fradelos, Evangelos, Hopping, Eve, Romo Ascencio, Evelia Veronica, Sosa Ferreira, Ever David, Shestakov, Evgenii, Tyurina, Evgenya, Hristova, Evguenia, Efthymiou, Evripidis, Tokidis, Evripidis, Harrison, Ewen, Dontoh, Ewurama Akroma, Mansour, Eyad, Yeshialem, Eyosiyas, Dabbagh, Ezeddin, Amer, Ezzeldin, Manasci, Fabiana, Gomes, Fabio, Medas, Fabio, d'Acapito, Fabrizio, Vassallo, Fabrizio, Haddad, Fadi, Elhabishi, Fadwa, Akhtar, Fahad, Tauheed, Fahad, Al Abbood, Fahd, Gareb, Fahed, Ghazali, Fairuz, Alnazawi, Faisal, Ondago, Faith, Rasoaherinomenjanahary, Fanjandrainy, Wiese, Fanny, González Ponce, Fanny Yesenia, Georgiades, Fanourios, Ali, Farah, Galley, Fareeda, Huda, Farhanul, Amir, Farhat Naaz, Ashraf, Fariha, Alfarsi, Faris, Ayasra, Faris, Ali, Farman, Mahmoud, Faten, Aliskander, Fater, Tahir Lwdie, Fathea, Buyuker, Fatih, Aguilar Del Castillo, Fátima, Mohammed Daoud, Fatima Ahmed, Alowjaly, Fatima, Oni, Fatima, Rauf, Fatima, Elkhafeefi, Fatimah, Hourri, Fatine, Monib, Fatma A., Alshreef, Fatma, Benghalbon, Fatma, Ntirenganya, Faustin, Ashraf, Fauziyah, Chahrour, Fayez, Ahmad, Fazal, Parray, Fazlul Qadir, Philips, Febi, Campus, Federica, Di Marco, Federica, Ferraina, Federica, Frongia, Federica, Maffeis, Federica, Natali, Federica, Pederiva, Federica, Scolari, Federica, Tofani, Federica, Marin, Federico Alberto Niccolò, Biolchini, Federico, Cappellacci, Federico, Corronca, Federico, Mazzola, Federico, Suldrup, Federico, Nyarko, Felicia, Casas J, Felipe, Zapata, Felipe, Aigner, Felix, Alakaloko, Felix, Amoako, Felix, Camacho, Felix, Hammett, Felix, Kuubetersob B. N, Felix, Alahmad, Feras, Alnimri, Feras, Haddad, Feras, Gool, Ferhana, Castro, Fernanda, Diaz, Fernanda, Lucero, Fernanda, Vovola, Fernanda, Mahnic, Fernando, Mercado Sanchez, Fernando, Prieto La Noire, Fernando, Soggiu, Fiammetta, Tsige, Fikreab, Brzeszczyński, Filip, Rudisch, Filip, Valente Costa Pinto, Filipa, Ramalho De Almeida, Filipe, Banchini, Filippo, Palomino Escalante, Fiorella, Fadzlullah, Fitri, Terefe, Fitsum, Sulo, Fjorenta, Ciccarone, Flavia, Tirelli, Flavio, Krämer, Florian, Grama, Florin, Spanos, Foivos, Solimene, Folco, Akinwande, Foluso, Osman, Forzia, Stefou, Foteini, Kyramargios, Fotios, Stavratis, Fotios, Alassani, Fousseni, Ascari, Francesca, Cammelli, Francesca, D'Agostino, Francesca, Tropeano, Francesca Paola, Peters, Francesca, Ré, Francesca, Brucchi, Francesco, Casti, Francesco, Coratti, Francesco, Ferrara, Francesco, Floris, Francesco, Izzo, Francesco, Maffei, Francesco, Palmieri, Francesco, Pata, Francesco, Porcelli, Francesco, Selvaggi, Francesco, Velluti, Francesco, Mulita, Francesk, Bello, Francis, Caiquo, Francis, Dossou, Francis, Eshun, Francis Junior, Opoku Twene, Francis, Tierenye, Francis, Quayson, Francis William, Romo Rosales, Francisco David, Ibañez Ortiz, Francisco, León Frutos, Francisco Javier, Redondo Calvo, Francisco Javier, Silva Rivera, Francisco Javier, Barbosa Camacho, Francisco José, Bujalance Cabrera, Francisco Manuel, Ruescas, Francisco, Irakiza, Franck Fanon, Corvatta, Franco, Pascual, Franco Raúl, Roviello, Franco, Roodt, Francois, Gyamfi, Frank Enoch, Olaniru, Frank, Owusu, Frank, Bader, Franz G., Anzinger, Franz-Xaver, Agbodo, Fred David Anku, Ris, Frederic, Agbemafoh, Frederick Mawuli, Afonso, Frederico, Nazareth, Frederico, Berrevoet, Frederik, Hounde, Fréjus, Demiral, Furkan, Hassooni, Furqan Ridha Hassooni, Kafa, Gabi, Cárdenas Rivera, Gabriel, Ntwari, Gabriel, Szydlo Shein, Gabriel, Ambriz González, Gabriela, Nita, Gabriela Elisa, Bellio, Gabriele, Moitzi, Gabriele, Urdang, Gabriella, Marom, Gad, Gallo, Gaetano, Luglio, Gaetano, Poillucci, Gaetano, Singh, Gagandeep, Saletta, Gaia, Abouelnagah, Galal, Yarovenko, Galina, Kazobinka, Gallina, Ahmed, Gamal Mutwakil Gamal, Rahman, Ganiyu Adebisi, Smith, Garett, Pillai, Gargi, Saxena, Garima, Gbessi, Gaspard, Nkunguzi, Gaston, Jalal, Gaurav, Chillarge, Gauri, Singh, Gautam, Mevognon, Gedeon, Getachew, Gedion, George, Gejoe, De La Peña González, Gema, Martínez Izquierdo, Gema, Grande, Gennaro, Birikorang, Geoffrey, Weber, Georg F., Singer, Georg, Ansong, George, Bashour, George, Brown, George Darko, Hneino, George, Kavalieratos, George, Kenchadze, George, Nagy, George, Pappas Gogos, George, Skroubis, George, Waiyaki, George, Cox, Georgia, Zeringa, Georgia, De Wee, Georgin, Hart, Georgina, Bekakos, Georgios, Fragulidis, Georgios, Kapogiannatos, Georgios, Karakaidos, Georgios, Kokkinos, Georgios, Kostoulas, Georgios, Koukoulis, Georgios, Peros, Georgios, Rados, Georgios, Tsoulfas, Georgios, Verras, Georgios-Ioannis, Berger, Geraint, Adoro, Gerard Ayuka, Chamoso Mialdea, Gerardo, Palmieri, Gerardo, Procaccini, Gerardo, Steenkamp, Gerhard, Viscido, Germán Rodrigo, Dajti, Gerti, Alemayehu, Getachew, Seyfu, Gezachew, Birqeeq, Ghada, Alsheikh, Ghadeer, Alrayyes, Ghaith, El Hunjul, Ghalib Nashaat, Zaza, Ghayath, Matroud, Ghazlah, Alhadwah, Ghena, Maltinti, Gherardo, Awais, Ghina, Shamsi, Ghina, Calini, Giacomo, Carganico, Giacomo, Zanus, Giacomo, Canu, Gian Luigi, Mendiola, Gian, Ibero Casadiego, Giana Pamela, Cocorullo, Gianfranco, Baronio, Gianluca, Pellino, Gianluca, Zanni, Gianluca, Poto, Gianmario Edoardo, Gravante, Gianpiero, Aduroja, Gideon, Almogy, Gidon, Bond-Smith, Giles, Natchagande, Gilles, Bechara, Gio, Brachini, Gioia, Riccioli, Giordana, Ercolani, Giorgio, Farris, Giorgio, Giraudo, Giorgio, Mammolo, Giovanna, Pavone, Giovanna, Sgarzini, Giovanna, Aprea, Giovanni, Fonsi, Giovanni Battista, Boroni, Giovanni, De Angeli, Giovanni, De Palma, Giovanni Domenico, Emiliani, Giovanni, Grava, Giovanni, Guercio, Giovanni, De Carlo, Giulia, Del Corpo, Giulia, Duranti, Giulia, Galatioto, Giulia, Grassi, Giulia, Graziano, Giulia, Marini, Giulia Maria Francesca, Munzi, Giulia, Tarantino, Giulia, Borda-Luque, Giuliano, Pellicano', Giuseppe Antonino, Canonico, Giuseppe, Carollo, Giuseppe, Ietto, Giuseppe, Palomba, Giuseppe, Pascarella, Giuseppe, Salamone, Giuseppe, Sica, Giuseppe, Sorrentino, Giuseppe, Orlando, Giuseppina, Pignata, Giusto, Pisarevi, Givi, Akcakoca, Gizem, Owusu, Godfred, Yohanna Abrak, Godwin, Kurtoglu, Gokalp Kagan, Kurtoglugk, Gokalp Kagan, Alıcı, Gökhan, Kurtoglu, Goktug Mert, Delgado Hernandez, Gonzalo, Augustin, Goran, Bhat, Gowhar Aziz, Sundaram Venkatesan, Gowtham, Chang, Grace, Eke, Grace, Lee, Grace, Massarra, Grace, Travaglini, Grazia, Scialandrone, Grazisa, Stavrou, Gregor A., Di Franco, Gregorio, Charalambous, Gregory, Christodoulidis, Gregory, Kouraklis, Gregory, Goodwin, Gregory Richard, Devidze, Grigol, Fialho, Guilherme, Santos, Guilherme, Cabezudo, Guillermo, García-Santos, Guillermo, Pou, Guillermo, Romero Reyna, Guillermo, Yanowsky-Reyes, Guillermo, Ozyuksel, Gul, Karadeniz Cakmak, Guldeniz, Kucuk, Gultekin Ozan, Bulbuloglu, Guney Cem, Sarp, Guray, Kaur, Gurleen, Nibogora, Guy Darcy, Hamdan, Gymar, Ogundipe, Habeeb, Yunes, Habib, Ayesh, Hadeel, Al Atassi, Hadi, Jalilehvand, Hadis, Masalma, Hafez, Jafarkhan, Hafis, Shahid, Hafiz Huzaifa, Younus, Hafsa, Al-Derume, Hail, Shames, Haitam, Mimouni, Haithem Ahmed, Aldare, Hajar, Odah Bashi, Hajar Omar, Abusnina, Hajer, Altounsi, Hajir, Qayum, Hajra, Baysal, Hakan, Bolukbasi, Hakan, Yigitbas, Hakan, Alkhatib, Hala, Afzal, Haleema, Mftah, Halima, Oyinlola, Halimah, Tümer, Haluk, Dolo, Hamadoun, Braham, Hamdi, Ozsahin, Hamdi, Abu-Arish, Hamdoon, Al-Aamri, Hamed, Fadlalmola, Hammad Ali, Abu Obead, Hamza, Al-Fahel, Hamza, Al-Zoubi, Hamza, Asaad, Hamza, Ejaz, Hamza, Jaber, Hamza, Bhatti, Hamza Waqar, Mohammadi Sardoo, Hamzeh, Farhat, Hana, Idheiraj, Hanadi, Zwaraa, Hanady, Al Sohabi, Hanan, Basharat, Hanan, Said, Hanan, Al-Abdallat, Haneen, Foad, Haneen, Daaboul, Hanen, Al Qadhi, Hani, Elhallaq, Hani, Alhusaini, Hanin, Lidbetter, Hannah, Reilly, Hannah, Moya- Ambriz, Hannia Betzabeth, Lederhuber, Hans, Fehrer, Hans-Jörg, Xiao, Haotian, Iswariah, Harish, Kaur, Harmeena, Cheema, Harnoor Kaur, Foda, Haroun, Chauhan, Harpreet, Kaur, Harpreet, Sagar, Harry, Unwin, Harry, Kaur, Harsharan, Panga, Harshavardhan, Gupta, Harshit, Prabhakar, Harshit Kumar, Anand, Harshitha, Pahwa, Harvinder Singh, Abbadi, Hasan, Amoudi, Hasan, Zaini, Hasan Hadi Zaini, Škiljo, Hasan, Miyasika, Hasangi, Altabbaa, Hashem, Haj Freej, Hasn, Abdelazim, Hassan, Habiba, Hassan, Kamal, Hassan, Sabir, Hassan, Zaigham, Hassan, Pehlivan, Hatice, Telci, Hatice, Abuobaida, Hayat, Tetley, Heather, Taher, Heba, Aguado López, Héctor, Askarpour, Hedyeh, Sherif Farouk Ahmed Hassan, Heidi, Devesa, Helena, Arbogast, Helmut, Nuñez Del Barrio, Henar, Abiyere, Henry, Delacave, Henry, Rice, Henry E., Pleass, Henry, Bradly, Hera, 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Rugambwa, Jean Paul, Jordaan, Jean- Jacques, Razafindrahita, Jeannie Ba, Do, Jee Eun, Senavirathna, Jeewantha, Kalyanapu, Jeffrey A, Chan, Jeffrey, Ofori, Jeffrey, Otote, Jeffrey, Akiely, Jehad, Cassiano Neves, Jelena, Gillingham, Jemima, Herrera Batres, Jenifer Olga María, Ezeh, Jennifer, Okei, Jennifer, Vu, Jennifer, Guevara, Jenny, Siu, Jenny, Rolinger, Jens, Skaff, Jeolle, Uys, Jernelle, Makama, Jerry Godfrey, Barklimore, Jessica, Dei-Asamoa, Jessica, Jahjah, Jessica, Jones, Jessica, Ng, Jessica, Ricardo, Jéssica, Schembri Higgans, Jessica, You, Jessica, Annan, Jessie, Aguilar, Jesus Antonio, Pizarro Lozano, Jesús, Lim, Jia Hui, Zhu, Jiang, Wang, Jianxue, Abbasy, Jibran, Ugwu, Jideofor, Rathod, Jignesh, Albalushi, Jihan, Najajra, Jinan, Fu, Jing Hui, Tefay, Joan Sia Tan, Domingues, Joana Cristina, Simoes, Joana FF, Figueiredo, Joana, Fontaínhas, Joana, Frazão, Joana, Marques Antunes, Joana, Simoes, Joana, Marx, Joanna Naemi, Dias-Ferreira, João, Fernandes, João, Mendes, João, Pinho, João, Ribeiro, João, Vaz, João, Dominguez, Joaquina, Abutu John, Job, Chen, Joe Jun Qiao, Enaholo, Joel, Alaji, Joelle, Miller, Johanna, Binder, Johannes, Daleku, John, Katogiritis, John, Khoury, John, Anyorigiya, John Noah, Reilly, John, Abebrese, John Tabiri, Ahale, Johnny Lordson, Tabora-Zepeda, Johnny, Barrutia Leonardo, Jon, Demma, Jonathan Abraham, Hong, Jonathan, Chejfec-Ciociano, Jonathan Matias, Oppong, Jonathan, Quansah, Jonathan, Sutcliffe, Jonathan, Taiwo, Jones, Nyamekye - Baidoo, Joojo, Prat-Ortells, Jordi, Dongmo, Jordy, Kleeff, Jorg, Jimenez Flores, Jorge Alberto, Pellecer Cano, Jorge Bernardo, Chóliz, Jorge, Giubi Bobeda, Jorge Eduardo, Escartin, Jorge, Febré, Jorge, Gass, Jörn-Markus, Calvache, Jose A, Guzman Barba, Jose Aldo, Gutiérrez Gómez, José Alonso, Calvache, Jose Andres, Acevedo Parrales, José Danilo, Orozco Navarro, José Esteban, Viñas, José Federico, Gomez, José, Goncalves-Nobre, Jose Guilherme, Valenzuela, José Ignacio, Garcia Galocha, Jose Luis, 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Marcella, Pisano, Marcello, Doniquian, Marcelo Alejandro, Martínez Bareiro, Marcelo Nicolás, Pagani, Marcelo, Scortechini, Marcelo, Carvalho, Márcia, Sánchez Audelo, Marco Antonio, Brizzolari, Marco, Ceresoli, Marco, De Prizio, Marco, Amisano, Marco Francesco, Gramellini, Marco, Marcianò, Marco, Mariani, Marco, Milone, Marco, Montagna, Marco, Piccino, Marco, Santos, Marco, Dyer, Marcus, Kang, Marcus, Mahadi, Mardhiana, Zawadzki, Marek, Yinusa, Margaret, Bernardo, Margarida, Nunes Luís, Margarida, Gambelli, Margherita, Flint, Margot, Aggelidou, Maria, Bequis, Maria Agustina, Sotiriou, Maria Aikaterini, Ñañez, Maria Alejandra, Tahir, Maria Ambreen, Gascón Domínguez, María Ángeles, Asimakidou, Maria, Mourato, Maria Beatriz, Blanco, Maria, Christou, Maria, Coronas Soucheiron, Maria, Pignanelli, Maria Costanza, Kalaydjian, María Cristina, Martí-Ejarque, Maria del Mar, Olmedo Reinoso, María Del Mar, Cebollero, María Del Pilar, Derattani, Maria, Gama Caldeira, Maria Do Carmo, Drogouti, Maria, Gonzalez-Gonzalez, Maria Elena, Muñoz Fernández, María Elena, Muriel, María Emilia, Duran, María Eugenia, Zarate Casas, María Fernanda, Florou, Maria, Piacentini, Maria Gaia, Seixo, Maria Inês, Bellini, Maria Irene, Peña Soria, Maria Jesús, Martínez, María José, Medina, Maria José, Rueda Medécigo, María José, Karakeke, Maria, Kausar, Maria, Kyriazi, Maria, Marqueta De Salas, Maria, Modolo, Maria Marta, Mateu, Maria, Mavri, Maria, El Ghoul Miliotou, Maria Melina, Moreno Gijon, Maria, Papadoliopoulou, Maria, Proclamà, Maria Pia, Picciochi, Maria, Reis, Maria, Rennis, Maria, D'Anna, Maria Rosa, Ruffoli, Maria, Ruiz Soriano, María, Sánchez Ramirez, Maria, Sánchez-Rubio, María, Schüler, Maria, Sotiropoulou, Maria, Barrio Renteria, Maria Teresa, Tsopozidi, Maria, Vasconcelos, Maria, Facchino, Maria Vittoria, Wikar, Maria, Aguilera-Arevalo, Maria-Lorena, Abdu, Mariam, Asarbakhsh, Mariam, Elmiesiry, Mariam, Ashong, Marian Esi, Gomes, Mariana, Capuano, Marianna, Lill, Marianne, Nieto Galvan, 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Nathan, Michael, Maclean, Michael, Nortey, Michael, Pellen, Michael, Pham, Michael, Pitiakoudis, Michael, Singh, Michael Prodip, Spartalis, Michael, Van Der Colf, Michael, Wilson, Michael, Billis, Michail, Karanikas, Michail, Papamichail, Michail, Vailas, Michail, Kisielewski, Michał, Kusiński, Michał, Nycz, Michał, Święch, Michał, Fagbayimu, Micheal, Adamina, Michel, Fiogbe, Michel, Prudhomme, Michel, Angelucci, Michela, Campanelli, Michela, Cricrì, Michele, Grande, Michele, Manigrasso, Michele, Scopelliti, Michele, George, Michelle, Mozel, Michelle, Galasyuk, Mick, Chevallay, Mickael, Giuliano, Micol, Dobón Rascón, Miguel Ángel, Fernandez Romero, Miguel Angel, García Ureña, Miguel Ángel, Zaragoza Mendieta, Miguel Ángel, Bejarano Serrano, Miguel, Brito, Miguel, Calderon, Miguel, Jurado Román, Miguel, Palas, Miguel, Li Valencia, Miguel Roberto, Sebastián-Mendoza, Miguel-Julián, Muresan, Mihai-Stefan, Slavchev, Mihail, Agapov, Mikhail, Milentijević, Milica, Catterall, Millie, 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Abosedra, Mohammed, Sarker, Mohammed Abu Kawsar, Abudabbous, Mohammed, Abuwarda, Mohammed, Elgak, Mohammed Ahmed, Al Hinai, Mohammed, Al Zebda, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Ali, Mohammed, Ismael Alamin, Mohammed Ali, Alqadasi, Mohammed, Alshanwani, Mohammed, Alshehri, Mohammed, Asaad, Mohammed, Bashir, Mohammed, Bohlala, Mohammed, Meghaizerou, Mohammed El Amine, Albanna, Mohammed Emad Hashem, Ghunaim, Mohammed, Goga, Mohammed, Hajhamad, Mohammed, Hamada Takrouney, Mohammed, Hammoda, Mohammed, Hamoud Almahly, Mohammed, Muragi, Mohammed, Mohammed, Mohammed Mustafa Hassan, Obaid, Mohammed, Omar, Mohammed, Said, Mohammed, Salah, Mohammed, Saleh Khatab, Mohammed, Aliyu, Mohammed Salele, Shakhshir, Mohammed, Sheriff, Mohammed, Tageldin, Mohammed, Abdelfattah, Mohanad, Daher, Mohanad, Lotfy, Mohanad, Alqedrh, Mohannad, Nasani, Mohannad, Mohd Shah, Mohd Shahrulsalam, Madany, Mohie El-Din Mostafa, Mobolaji-Ojibara, Mojisola, Nkogatse, Moleseng, Alazabi, Mona, Gupta, 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Mamduh, Samah, Omar, Samah, Altaf, Saman, Dos Santos Rocha Ferreira, Samantha, Quoy, Samantha, Emile, Sameh, Abu Salem, Samer, Al Athath, Samer, Yigman, Samet, Eldirdiri, Sami, Imam, Sami, Jomaa, Sami, Errami, Samia, Kessab, Samia, Muhammad, Saminu, Delibegovic, Samir, Kanaan, Samir, Aliozor, Sampson, Olori, Samson, Sani, Samuel Ali, Anim, Samuel, Bennett, Samuel, Debrah, Samuel, Ghattas, Samuel, Brenu, Samuel Gyasi, Robinson, Samuel James Alexander, Arthur, Samuel Joseph, Mcclintock, Samuel, Mensah, Samuel, Ogunlade, Samuel, Tingle, Samuel, Jabeen, Sana, Borrego Canovaca, Sandra, De La Cruz Ahufinger, Sandra, Tsoti, Sandra Maria, Paterna -Lopez, Sandra, Sanz, Sandra, Tsatsu, Sandra, Hügli, Sandro, Yunusa, Sani Abdullahi, Aji, Sani Ali, Katragadda, Sanjay, Edem, Sanketh, Irrinki, Santhosh, Shivashankar Chikkanayakanahalli, Santhosh, Bertone, Santiago, Karmarkar, Santosh, Abbas, Sara, Alashhab, Sara, Alsaeiti, Sara, Andrade, Sara, Egreara, Sara, Elfallah, Sara, Galati, Sara, García López, Sara, Giovampietro, Sara, Ismail, Sara, Kamari, Sara, Lauricella, Sara, Marzorati, Sara, Mohammed, Sara, Moschella, Sara, Mostafa Yassin, Sara, Patrocínio, Sara, Massa, Sara Tiziana, Vertaldi, Sara, Abdelmohsen, Sarah, Al Sharie, Sarah, Barbosa Castelo Branco, Sarah, Bowman, Sarah, Condron, Sarah, Elfurdag, Sarah, Ellouzy, Sarah, Fennelly, Sarah, Mansour, Sarah, Molfino, Sarah, Qwyder, Sarah, Rennie, Sarah, Robinson, Sarah, Segnitome, Sarah, Staight, Sarah, Yassin, Sarah, Alsibai, Sareyah, Khan, Sarfaraz, Khurana, Sarita, Rafiq, Sarmad, Malhi, Sarvpreet Singh, Dognia, Satchmo, D A, Sathiafrey, Babu, Satia, Subbiah Nagaraj, Satish, Meena, Satya Prakash, Vasquez, Saul, Bradulskis, Saulius, Mikalauskas, Saulius, Laura, Saura García, Verhage, Savannah Skye, Simeonidis, Savvas, Sarwary, Sayed Haschmatullah, Naidu, Sayuri, Schimpke, Scott, Davis, Sean, Stevens, Sean, Sierra, Sebastian, Dos Santos, Sebastiano, Strachan, Sebastien, Bektas, Sebnem, Atupra, Sedinam Adjoa Asiedua, Kreid, Sedra, Bugren, Seeraj, Saudí-Moro, Sef, Ashini, Sehar, Aboseif, Seif, Abdul Rahman, Seif-Aldin, Karim, Seiver, Öztürk, Selen, Akuffo, Selma, Awad, Selmy, Srishankar, Selvaratnam, Tobome, Sèmèvo Romaric, Malek, Sepand, Quartarone, Serafino, Grimaldi, Serena, Guarriello, Serena, Kalenga, Serge, Katorkin, Sergei, Trujillo Ponce, Sergio Adrian, Villeda, Sergio Alejandro, Intini, Sergio Giuseppe, Vázquez-Sánchez, Sergio Jiram, Salido, Sergio, Valeri, Sergio, Yilmaz, Serhan, Meriç, Serhat, Bensalem, Serien, Sucu, Serkan, Yılmaz, Serkan, Uludağ, Server Sezgin, Torres Rodríguez, Servio Tulio, Ooi, Sett, Luciano, Severino, Houndji, Sèwou Francklin Albert, Agordjor, Seyram, Ward, Sezar, Samardali, Shaden, Altoume, Shadi, Mahfoud, Shafik, Razaq, Shahad, Khan, Shahbano, Husanov, Shahboz, Ahmed, Shaheer, Islam, Shahnoor, Waqar, Shahzad Hussain, Kumaran, Shairashree, Magrhi, Shamsa, Zhang, Shane, Kashyap, Shankarsai, Karandikar, Sharad, Sundaramurthy, Sharada, Chowdhury, Sharfuddin, Jayasekara, Sharitha, Laura, Sharon, Shanker, Shashwat, Ababneh, Shatha, Gilbert, Shaun, Kenworthy, Shaunna, Ng, Shawn Hong Ming, Mackenzie, Shawn, Salindera, Shehnarz, Khattak, Shehrbano, Loke, Sheih Nee, Manzoor, Sheikh Viqar, Alwardi, Sheikha, Allam, Shereen, Tawfik, Sherifa, Francis, Shikha, Cai, Shirley, Dindyal, Shiva, Pandya, Shivangi, Chopra, Shreya, Ingley, Shreya, Kulkarni, Shrirang, Kosna, Shuba, Nayak, Shubhalaxmi, Ahuja, Shubham, Hariharan, Shubhang, Karuppusamy Krishnasamy, Shyam, Khare, Siddhant, Handa, Siddhartha, Amin Omar Alsiddig, Siddig, Alqurashi, Siddiga, Al-Tahayneh, Sief-Addeen, Sibiya, Silindokuhle, Perretta, Silvana, Ibarra Camargo, Silvia Alejandra, Montisci, Silvia, Mungo, Silvia, Puddu, Silvia, Severi, Silvia, Agudelo Mendoza, Silvia Valentina, Makkai-Popa, Silviu Tiberiu, Boyes, Simon, Monkhouse, Simon, Stock, simon, Alberti, Simona, Meneghini, Simona, Giudici, Simone, Guadagni, Simone, Birolo, Simone Lorenzo, Novello, Simone, Oliveira, Simone, Gumede, Simphiwe, Dhole, Simran, Budhwani, Simran Saleem, Ramjit, Sinead, Yumurtacilar, Sinem, Mahendra, Sirigi Naga, Abeykoon, Sithira, Moh Pauzi, Siti Farhan, Rajendra, Sittampalam, Sundararajan, Siva, Gananadha, Sivakumar, Kamarajah, Sivesh K, Marawu, Siyasanga, Basu, Sk, Hassan, Sleman, Reddy, Snigdha Mettu, Anaya Sanchez, Sofia, Gaspar Reis, Sofia, Gomez, Sofía, Gamba, Sofia Lucia, Pimentel Morais, Sofia, Ashry, Soha, Abdullateef, Sohaila, Bandyopadhyay, Soham, Samadi, Soheil, Pathan, Sohilkhan R., Lakew, Solomon, Basu, Somprakas, Ohri, Sonali, Alonso Marcos, Sonia, Amoza Pais, Sonia, Fortuna Martins, Sónia, Gill, Sonia, Matthiess, Sonia, Sabbatini, Sonia, Soto Schütte, Sonia, Engel, Sophie, Eam, Sothseyhakmonique, Botaitis, Sotirios, Lawani, Souliath, Jamil, Soumaya, Kondpan, Sourav, Oum, Sovannarith, Govender, Sovishnee, Christodoulou, Spyridon, Davakis, Spyridon, Vernadakis, Spyridon, Gkogkos, Spyros, Gobishangar, Sreekanthan, Suresh, Sreelakshmi, Vembar, Sridhar, M, Srikanth, Abdelrasoul Elnour Ismail, Srraa, Zourntou, Stamatina-Emmanouela, Nwabuoku, Stanley Emeka, Ideh, Stanley, Charitonos, Stavria, Liapis, Stavros Chrysovalantis, Faber, Stefan, Piccioni, Stefania Angela, Romano, Stefania, Silvestre, Stefania, Jarmusch, Stefanie, Soelling, Stefanie, Cardelli, Stefano, Chaifouroosh Mamagany, Stefano, Corso, Stefano, Basso, Stefano Maria Massimiliano, Megna, Stefano, Bitsianis, Stefanos, Tsatsos, Stefanos, Morales, Steffanía, Gerdes, Stephan, Göller, Stephanie, Hanna, Stephanie, Tabiri, Stephen, Agana, Stephen, Theivendran, Stephen Arthur, Kache, Stephen, Knight, Stephen R, Smith, Stephen, Stonelake, Stephen, Wrenn, Stephen, Gopaul, Steven, Vederaki, Styliani, Kapiris, Stylianos, Kykalos, Stylianos, Hlaing, Su Su, Chia, Su Yin Denise, Abu Khousa, Suad, M. Udwan, Suad, Raul, Subrat, Chase, Suchita, Nair, Sudharrshan, Joseph, Sudhir, Singh, Sudhir Kumar, Singh, Sudhir, Timmalah, Suhaylah, Alsuwiyah, Suhir, Thalgaspitiya, Sujeewa Priyantha Bandara, Sellahewa, Sujeewa, Neogi, Sujoy, Burger, Sule, Polat, Süleyman, Alkadi, Sulman, Asiri, Sultan, Otho, Sumaira, Mewa Kinoo, Suman, Ebrahim, Sumayyah, Tontus, Sumeyya, Midya, Sumit, Thuraisamy Sarma, Sundaramoorthy Iyer, Payyanur Thotan, Sundeep, Kumar Venkatappa, Sunil, Techapongsatorn, Suphakarn, Kaur, Supreet, Jp, Supritha, Tan, Suqi, Djote, Surafel Mulatu, Surendran, Suraj, Singh, Surendra, Chilaka, Suresh, Lee, Susan, Henriques, Susana, Giridaran, Suseendirarajah, Achugatla, Sushma, Kumar, Suvam, Brincat, Svetlana, Deshpande, Swati, Batista, Sylvia, Akharaekpanya, Tachporn, Moges, Tadesse Girma, Türkmen, Taha Berkay, Alhaj Hasan, Taima, Alshawabkeh, Taima', Majed, Taima', Lawal, Taiwo Akeem, Ibiyeye, Taiye Taibat, Rashid, Tajamul, Košir Božič, Tajda, Mohammed, Tajudeen, Khewater, Talal, Abelman, Talia, Al Barhi, Tamadher, Mogne, Tamiris, Salazar-Lorenzana, Tania Abril, Akter, Tania, Gómez Sanz, Tania, Motiwala, Tanmay, Valizadeh Elizeh, Tanya, Almahdi, Tanzeel, Albushary, Tanzel Alrahman, Abdulrahman, Taofeeq, Finlay, Tara, Chouari, Tarak, Awad, Tarek, Sabra, Tarek, M. Abubasheer, Tareq, Alhusban, Tariq, Yılmaz, Tarık Emre, Aloqaili, Tasneem, Aldirawi, Tayef, Karahasanoğlu, Tayfun, Gülşen, Taygun, Jemal, Tebarek, Nadeem, Tehmina, Singh, Tejinder Paul, Alinger, Temsula, Longkumer, Temsutoshi, Lo, Terence, Gimenez Maurel, Teresa, Uprak, Tevfik Kıvılcım, Petropoulou, Thalia, Rawther, Thampi, Techapongsatorn, Thawin, Manickam, Thendral, Padioti, Theodora, Kozonis, Theodoros, Sidiropoulos, Theodoros, Tsirlis, Theodoros, Theodosopoulos, Theodosios, Hessou, Thierry Kinnongni, Uiyapat, Thitapon, Agyen, Thomas, Harris, Thomas, Hugh, Thomas J, Jorgensen, Thomas W., Theivendrampillai, Thrshegan, Pham, Thuy Vy, Branco, Tiago, Nagwamutse, Tijjani Nasiru, Tony V, Tina, Devabalan Koil, Titus, Pilia, Tiziana, Abdulmola, Tmador Mahmed Ali, Oyeyemi, Tobiloba, Kebede, Tolera, Ibarra-Hurtado, Tomás Ramón, Reichelt, Tomas, Gach, Tomasz, Stefura, Tomasz, Wojewoda, Tomasz, Soric, Tomislav, Risteski, Toni, Tridip, Tridip Dutta Baruah, Yotsov, Tsanko, Doma Bhutia, Tshering, Girma, Tsion, Kwan, Tsun Yu, Ivanov, Tsvetomir, Iahmo, TT, Ashkar, Tuleen, Mabogoane, Tumi, Olobatoke, Tunde, Sholadoye, Tunde T., Mishra, Tushar Subhadarshan, Parker, Tyla, Ezomike, Uchechukwu, Dilibe, Uchenna, Kumbhar, Uday, Una, Uduak-Abasi, Grossi, Ugo, Ezidiegwu, Ugochukwu, Edith, Ugwuoke, Daspal, Ujjwal, Kalu, Ukoha Agwu, Dietz, Ulrich, Ronellenfitsch, Ulrich, Wirth, Ulrich, Abdullah, Umar, Rivolta, Umberto, Jayarajah, Umesh, Kanyan Kassim, Umu-Hera, Govindan, Unnikrishnan, Fernandes, Urânia, Akram, Usman, Mohammed Bello, Usman, Omara, Usra, Naidoo, Uvarasen, Mahendravarman, Vaishnaivy, Negoita, Valentina Madalina, Mariottini, Valentina, Murzi, Valentina, Zucchini, Valentina, Agbakwuru, Valentine, Armenta Tapia, Valeria Estefania, Gentilino, Valerio, Borgogni, Vanessa, Ng, Vanessa, Wolfschluckner, Vanessa, Silvestri, Vania, Žufić, Vanja, Gunasaegaram, Varman, Kamalathevan, Vasan, Pillay, Vasanthan, Neykov, Vasil, Kalles, Vasileios, Mousafeiris, Vasileios, Papadopoulos, Vasileios, Tsaousis, Vasileios, Tselepidis, Vasileios, Vougas, Vasileios, Georgilaki, Vasiliki, Nikolaou, Vasiliki, Themelidi, Vasiliki, Manchev, Vassil, Ioannou, Veatriki, Jha, Vedant Shekhar, Dragisic, Vedran, Sutharshan, Vengadasalam, Alonso, Veronica, Brocco, Veronica, Ongil Rodríguez, Verónica, Schirinzi, Veronica, Budyakova, Veronika, Naunova, Vesna, Panduro-Correa, Vicky, Ruiz López, Víctor Andrés, Bill, Victor, Dassah, Victor, Gonzabay, Víctor Eduardo, Etwire, Victor, Modekwe, Victor, Serna-Alarcon, Victor, De Donato, Victor Ugo, Duque Mallén, Victoria, Liu, Victoria, Sharma, Vidushi, Kumar, Vijaya, Muralidharan, Vijayaragavan, Kakotkin, Viktor, Enemuo, Vincent, Kudoh, Vincent, Osoka, Vincent, Siepaal, Vincent, Granata, Vincenza, Dinuzzi, Vincenza Paola, Lizzi, Vincenzo, Ricchiuti, Vincenzo, Mosca, Vinicio, Kanna D, Vinoth, Nair, Vipin Venugopal, Ledda, Virginia, Michael, Vishal, Singh, Vishavdeep, Govindasamy, Vishendran, Kollengode, Viswanathan V, Giordano, Vittoria, Morinelli, Vittoria, Lin, Vivian, Cuk, Vladica, Cijan, Vladimir, Çalik, Volkan, Bakshi, Vrushank, Ten, Vyacheslav, Ratheesh, Vysakh, Alsado, Wael, Mayo, Wafik, Yang, Wah, Rehman, Wajeeh Ur, Abbas, Walaa, Al-Khyatt, Waleed, Mabood, Waleed, Santucci, Walter, Yew, Wan Ting, Tahir, Warda, De Silva, Warusha Dhammika Dulantha, Wijenayake, Wasantha, Almadhoun, Waseem J.N., Alhroub, Wasef, Ebrahim, Wesam, Jabłoński, Wiktor, Krawczyk, Wiktor, Bhatti, William, Lai, William Kwan Ho, Petrushnko, Wilson, Afedo, Wisdom, Kasetsermwiriya, Wisit, Serednicki, Wojciech, Wysocki, Wojciech, Zerefa, Wondwossen Amtataw, Vagena, Xanthoula, Tarrado, Xavier, Papazarkadas, Xenofon, Po, Xiang Yuen, Ouadi, Yacine, Myla, Yacob, Haido, Yacoub, Hasan, Yafea, Karataş, Yağmur, Carpio Colmenares, Yahaira, Galvañ Félix, Yaiza, Balogun, Yakub Lekan, Maktabi, Yaman, Nerabani, Yaman, Fulgence, Yamuremye, De Silva, Yannick, Asar, Yara, Samer Morsy, Yara, Ghaleb, Yasameen Saif Saeed Mohammed, Vashishth, Yash, M S, Yashas, Manickchund, Yashoda, Sakaray, Yashwant, Kara, Yasin, Tosun, Yasin, Zwain, Yasir, Farag, Yasmeen, Jedidi, Yasmine, Seada, Yasmine, Aldebasi, Yasser, Ashour, Yasser, Badr, Yassin, Sarpong, Yaw, Alawneh, Yazan, Aung, Yee Lay, Orabi, Yehia, Lam, Yick Ho, Şen, Yigit Kaan, Koyluoglu, Yilmaz Onat, Huang, Yining, Mintz, Yoav, Perez, Yocarli, Chamara, Yohan, Melkamu, Yohannes, Maestre González, Yolanda, Dean, Yomna, Metaferia, Yonas Yilma, Malki, Yosra, Mohamed, Younis, A. Omar, Yousef, Alhammoud, Yousef, Allaoua, Yousef, Tanas, Yousef, El Okazy, Youssef, Kerolous, Youssef, Mohamed, Youssef, Al-Junaidi, Youssuf, Lakdawala, Yousuf, Lu, Yuann, Asano, Yukio, Altinel, Yuksel, Aktimur, Yunus Emre, Fishman, Yuri, Kudryavcev, Yurii, Tandoğan, Yusuf Iskender, Razafimandimby, Yves Michaël, Adofo-Asamoah, Yvonne, Şenol, Zafer, Odeh, Zahra, Benamrouche, Zahra Rayane, Alkhaier, Zahraa, Al-Sheikh Ali, Zaid, Zaher, Zain Aldin, Alnajjar, Zaina, Al-Balushi, Zainab, Alkhuzaie, Zainab, Khraim, Zakaria, Toutounji, Zakaria, Djama, Zakarya, Farraj, Zamil, Shah, Zamir Ahmad, Khan, Zara, Khan, Zarnigar, Abo Alarous, Zayn Alabden, Asaad, Zaynab, Demetrashvili, Zaza, Lorenc, Zbigniew, Brekalo, Zdrinko, Hannouneh, Zein Alabdin, Robertson, Zelda, Bady, Zeyad, Durna, Zeynep, Wong, Zhen Yu, Fozo, Zien Alabdin, Klib, Zienab, Chin, Ziling, Tamou, Zime Farid, Johnson, Zina, Shabello, Ziyad, Orzeszko, Zofia, Aljalabi, Zohal, Al-Azher El-Hamel, Zohour, Karampotaki, Zoi Rafaila, Valera Sanchez, Zoraida, Matkovic, Zoran, Azhar, Zubair, Qureshi, Zubaria, Correa López, Zulema Margarita, Balciscueta, Zutoia, Musilová, Zuzana, Katusic, Zvonimir, Osama, Zyad, and Dauksa, Zygimantas
Published: 2024
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37. EM Fault Injection-Induced Clock Glitches: From Mechanism Analysis to Novel Sensor Design.

Author: Roukoz Nabhan, Jean-Max Dutertre, Jean-Baptiste Rigaud, Jean-Luc Danger, and Laurent Sauvage
Published: 2024
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38. New Media and Convergence: The Existence Of The Banyumas Wayang Museum As One Of Indonesia’s Cultural Heritage In The Era Of Disruption 5.0

Author: Qolban, Anas Azimi, Muttaqin, Ahmad, Herdiyana, Hendra, Nabhan, Naufal, Putri, Inggit Melani, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Hidayat, Nasrullah, editor, Soiman, Soiman, editor, Yusriani, Irma, editor, Kamalia, Kamalia, editor, Khatibah, Khatibah, editor, and Rozi, Fakhrur, editor
Published: 2024
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39. Review of Completeness of Safety Equipment and Certification for Traditional Ships at Simanindo Port, Samosir Regency, North Sumatera Province

Author: Tungkup, Doharman Lumban, Santoso, Dalimunte, Irham Hasahatan, Nabhan, Sultan Naufal, Appolloni, Andrea, Series Editor, Caracciolo, Francesco, Series Editor, Ding, Zhuoqi, Series Editor, Gogas, Periklis, Series Editor, Huang, Gordon, Series Editor, Nartea, Gilbert, Series Editor, Ngo, Thanh, Series Editor, Striełkowski, Wadim, Series Editor, Pusriansyah, Ferdinand, editor, Sutrisno, Slamet Prasetyo, editor, Diani, Oktrianti, editor, Amanda, Monica, editor, and Triwahyuni, Siti Nurlaili, editor
Published: 2024
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40. Primary pulmonary mucosa-associated lymphoid tissue lymphoma with extensive lung involvement and negative autoimmune and inflammatory background: A case report and literature review

Author: Abdulrahman I. Alabdulgader, Arwa A. Nabhan, Arwa M. Althubaity, Abir H. Alsaid, Hind S. Alsaif, Hossain A. Abualola, Mohammed A. Al-Mulhim, Ahmed A. Alsayyah, and Mohammed I. Aldarweesh
Subjects: extranodal marginal zone lymphoma, negative autoimmune mucosa-associated lymphoid tissue lymphoma, primary pulmonary mucosa-associated lymphoid tissue lymphoma, Public aspects of medicine, RA1-1270
Abstract: Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a very rare presentation of MALT lymphoma. The presence of a completely negative autoimmune and inflammatory background makes it a real challenge and very rare presentation (probably the second reported case in the literature). We report a case of primary pulmonary MALT lymphoma with negative autoimmune background, demonstrating as multifocal bulky variceal masses causing significant clinical symptoms.
Published: 2024
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41. Implementing Deep Learning-Based Intelligent Inspection for Investment Castings

Author: Yousef, Nabhan and Sata, Amit
Published: 2024
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42. Characterization of β-glucan obtained from Candida albicans of caprine mastitis

Author: Saddam Hussein Mahmoud and Shaimaa Nabhan Yassein
Subjects: subclinical mastitis, mycotic mastitis, hplc, electron microscopy, iraq, Zoology, QL1-991
Abstract: Background: Beta-glucan (β-glucan) is a polysaccharide containing β-glycosidic bonds that is an important structure part of different yeast cells. Aim: The purpose of the study is to characterize β-glucan that obtained from Candida albicans (C. albicans) isolated from caprine mastitis. Methods: The β-glucan was extracted by using utilizing an Alkaline-acidic extraction technique. The dry weight of extracted β-glucan was 7.47/150 gm with 4.98%. Results: The findings demonstrated that the extracted β-glucan had similarity in the primary peak 5.78 of liquid samples using the method of High-Performance Liquid Chromatography (HPLC) when compared to the standard form of β-glucan. However, Scanning Electron Microscopy (SEM) studies revealed which the standard of β-glucan was distinct in morphology but similar to β-glucan isolated from C. albicans in terms of particle sizes in the range of 1.60-2.65 m and the lack of cell wall traces. The findings of an investigation using Energy Dispersive X-ray Fluorescence Spectroscopy (EDS/EDX) of extracted and standard β-glucan, showed the principal elements discovered were carbon (C), oxygen (O), and nitrogen (N). Aluminum (Al), silicon (Si), nickel (Ni), and gold (Au) were also present, but in less amounts. Conclusion: The extracted β-glucan displayed a high degree of similarity and purity to the standard β-glucan, according to the findings of Fourier Transform Infrared Spectroscopy (FT-IR) research. [Open Vet J 2024; 14(5.000): 1269-1280]
Published: 2024
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43. Account Given by Ernesto Molina, Great-Great-Grandson and Descendant of Jesús Ávila Sánchez and Dolores Casanova Villegas

Author: Nabhan, Gary Paul and Monti, Laura
Published: 2024
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44. Effects of electromagnetic therapy on proprioception in a rodent animal model of rheumatoid arthritis

Author: Mahmoud Nabhan, Haitham Sharaf El-Din Mohammed, Nabila S. Hassan, Tasneem Mohammad, Nagwa Abu Elwafa, Hend Wageh, and Mirna M. Elias
Subjects: electromagnetic therapy, mechanoreceptor, proprioception, fascia, freund’s adjuvant, rheumatoid arthritis, Medicine
Abstract: Introduction This study aimed primarily to investigate the effect of a PEMF on proprioception in terms of mechanoreceptor number and function and secondarily to assess the gait quality (sciatic function index) and arthritis severity (paw volume and body weight) in adjuvant-induced arthritis (AIA) RA model. Methods Twenty-eight healthy adult male Wistar rats were randomly divided into 3 groups: (I) RA experimental model treated with a PEMF (10 animals), (II) positive control (10 animals), and (III) negative control (8 animals). Group I was exposed to a PEMF (0.3 mT 1 h/day for 2 weeks), while Groups II and III were placed in the same setup, except that the PEMF was turned off. The proprioceptive function [as tactile response (TR) / hopping response (HR) / forelimb placing test (FPT)], paw volume (PF), and mechanoreceptor numbers were then tested. Results There was a significant preservation of mechanoreceptor numbers and proprioception in group I compared to group II, as follows: the number of Ruffini corpuscles mechanoreceptors ( p = 0.007) and TR on days 9 and 14 ( p = 0.002, 0.012, respectively) with no significant difference compared to group III. Also, PV decreased significantly in group I relative to group II ( p = 0.01) with no significant difference for group III. Conclusions PEMF significantly preserved proprioception receptors and function and decreased inflammation severity in the AIA-RA model.
Published: 2024
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45. List of contributors

Author: Adu, Agatha Oluwafunmilayo, primary, Alshammari, Nawaf Abbas, additional, Amponsah, Mark Kwaku Owusu, additional, Andrade, Gabriel, additional, Asante, Kwaku Oppong, additional, Ashworth, Georgia, additional, Bedewy, Dalia, additional, Bonfá-Araujo, Bruno, additional, Boutoleau-Bretonnière, Claire, additional, Bulteau, Samuel, additional, Carvalho, Lucas de Francisco, additional, Çelik, Eyüp, additional, Cevasco, Jazmín, additional, Cheal, Beth, additional, Chiclana-Actis, Carlos, additional, Coxon, Kristy, additional, EL Haj, Mohamad, additional, Elhai, Jon D., additional, Elsantil, Yasmeen, additional, Hamza, Eid Abo, additional, Hronis, Anastasia, additional, Humbert, Ilia, additional, Ismail, Nurzali, additional, Khalil, Elham A., additional, Küçükkambak, Selçuk Efe, additional, Laurin, Andrew, additional, Lima-Costa, Ariela R., additional, Lisasi, Jessica, additional, Ma, Samuel, additional, Machado, Gisele Magarotto, additional, Mahama, Inuusah, additional, Mestre-Bach, Gemma, additional, Miezah, Daniel, additional, Montag, Christian, additional, Montejo-González, Ángel Luis, additional, Moustafa, Ahmed, additional, Nabhan-Abou, Nidal, additional, Nkrumah, Ivy Kesewaa, additional, Noor, Shuhaida Md., additional, Otanga, Habil, additional, Oti-Boadi, Mabel, additional, Pispira, Joselyn, additional, Sassover, Eli, additional, Sauvaget, Anne, additional, Schmitt, Helena, additional, Silva, María Luisa, additional, Testa, Giulia, additional, and Weinstein, Aviv, additional
Published: 2024
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46. Impulsivity and intimate partner violence

Author: Humbert, Ilia, primary, Laurin, Andrew, additional, Sauvaget, Anne, additional, Nabhan-Abou, Nidal, additional, and Bulteau, Samuel, additional
Published: 2024
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47. Exploring the differences in the tumor microenvironment and immuno-oncologic targets in pancreatic ductal adenocarcinomas (PDAC) according to KRAS mutational status

Author: E.B. Faber, Y. Baca, J. Xiu, P. Walker, G. Manji, S. Gholami, A. Saeed, A. Prakash, G.P. Botta, D. Sohal, H.J. Lenz, A.F. Shields, C. Nabhan, W. El-Deiry, A. Seeber, V. Chiu, J. Hwang, and E. Lou
Subjects: pancreatic cancer, pancreatic adenocarcinoma, KRAS, genomics, tumor microenvironment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Background: The majority of pancreatic ductal adenocarcinomas (PDACs) are driven by mutant (mt) KRAS. How mt KRAS and co-driver mutations affect the immune cell (IC) landscape of PDAC remains uncertain. Herein, we characterize the types of IC in the PDAC tumor microenvironment (TME) and the prevalence of immuno-oncologic (IO) biomarkers by genomic and transcriptomic analysis in the context of KRAS status. Materials and methods: 4142 PDAC and 3727 colorectal cancer (CRC) cases with KRAS mt were analyzed using next-generation DNA sequencing, immunohistochemistry, and whole-transcriptome RNA sequencing. Microsatellite instability and deficiency in mismatch repair (MSI-H/dMMR) and tumor mutational burden (TMB) were also assessed. Results: We found KRAS mt in 81% of PDAC, with the most common variant being G12D in PDAC, and fewer cases of KRAS mt were co-expressed with the predictive IO marker MSI-H/dMMR than KRAS-wild-type (wt). However, KRASG12D, KRASG12V, and KRASQ61 mutations had significantly lower TMB than KRAS wt tumors in PDAC. The IC environment of KRAS mt PDAC showed significant differences in nearly all IC types; a similar pattern was observed in CRC but was less pronounced. Conclusions: Therapeutic IO targets like programmed death-ligand 1 are enriched in pancreatic adenocarcinoma cases harboring specific targetable variants of KRAS mt PDAC. Better understanding of the TME could lead to tailored immunotherapeutic strategies to overcome these barriers in KRAS mt PDAC, possibly in combination with molecularly targeted treatment strategies.
Published: 2024
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48. Developing E-Module Accounting Cycle based on Problem-Based Learning (PBL): Can it Improve Students' Critical Thinking Abilities?

Author: Yeyen Suryani, Iskandar, Fifit Nabhan Nurfitriani, Rani Tania Pratiwi, Muhammad Hasan, Nur Arisah, Nur Aeni, and Akhtem A. Dzhelilov
Subjects: E-Module Accounting, Problem Based Learning, Critical Thinking Ability, Education, Education (General), L7-991
Abstract: The limitations of teaching materials in the new curriculum, namely the independent curriculum and technological advances. It has a good impact on education to support the achievement of 21st century skills. E-modules could be used as an alternative learning resource that was practical and contextual, because they could be used anywhere and the material presented was relevant to real life. The article aimed to produce e-module based on PBL valid, practical, and accounting cycles to determine the effectiveness of the e-module on students' critical thinking skills. The researchers used development research, adapting the ADDIE model (analyze, design, develop, implement, and evaluate). In testing the effectiveness of this e-module, there was a significant increase because the value of the learning effectiveness of students after being given treatment was higher than without being given treatment. The implication of this research showed that educators must implement PBL assisted by e-modules, especially in accounting subjects, to improve students' critical thinking. Students were able to formulate learning problems, analyze problems, students used clear language, and draw learning conclusions. It gave an implication provision for students to develop their critical thinking skills. An important implication for the future that could be made was by paying attention to designs that were more appropriate to student needs, integrating content that was relevant to real life, and providing adequate training to teachers, it can increase the effectiveness of the module in improving students' critical thinking abilities.
Published: 2024
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49. Clinical Manifestations of Runny nose among Patients Attending Baqubah Teaching Hospital

Author: Qays Jaafar Khalaf,, Ali Lafta Salman,, Mohammad Abdelmajid Al katatbeh,, and Sura Nabhan Hussein
Subjects: Runny nose, nasal obstractions, nasal pruritis, stuffy nose, Medicine
Abstract: Background: The runny nose refers to a discharge (fluid) coming from the nasal passages.Runny nose is associated with inflammation and swelling (congestion) of the inner lining of the nasal passages and sinuses. May associated with atopic condition the patient complain from nasal obstruction, runny nose, episode of sneezing, and nasal pruritis. Objective: To examine the demographic distribution, clinical features, and age disparities among male and female patients with Runny nose (Rhinorrhea). Patients and Methods: A study was done on 100 AR patients at Baqubah Teaching Hospital. Information on demographics, clinical symptoms, and age variations between males and females were gathered and examined through the use of descriptive statistics and independent sample t-tests. Results: The Findings revealed that most of the subjects were women (56%) and homemakers (38%), with an average age of 29.73 years. Frequent symptoms comprised of sneezing (93%), runny nose (83%), itchy nose (74%), and stuffy nose (92%). There was no notable variation in age between males and females (p = 0.139). Conclusion: Clinical symptoms of runny nose are often recognized consist of rhinorrhea, sneezing, obstruction of the nasal passages with lacrimation and pruritus of the nasal mucosa, conjunctiva and oropharynx with history of allergic rhinitis. Conditions commonly associated with allergic rhinitis include asthma, sinusitis, allergic conjunctivitis and atopic dermatitis. Long standing disease can lead to mucosa remodeling, atrophic skin changes, nasal infection and overall increased morbidity.
Published: 2024
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50. Flexural behavior of RC beams incorporating recycled concrete aggregate and reclaimed asphalt pavement exposed to elevated temperatures

Author: Ahmed Ashteyat, Ala Obaidat, Mujahed Nabhan, and Tarik Kharabsheh
Subjects: Flexural behavior, Reinforced concrete (RC) beams, Recycled coarse aggregate (RCA, Recycled asphalt paving (RAP), Elevated temperatures, Technology
Abstract: Reducing the environmental footprint of concrete is one of the most effective methods to mitigate climate change since cement production contributes to about 8 % of global CO2 emissions. This paper presents an experimental investigation into the strength and flexural performance of reinforced concrete (RC) beams incorporating natural aggregate (NA), recycled concrete aggregate (RCA), and reclaimed asphalt pavement concrete (RAP) at normal and elevated temperatures. The NA was replaced by RAP at three replacement ratios of 40 %, 60 % and 80 %. Additionally, there were four mixes of 80 % RCA-20 % RAP, 60 % RCA-40 % RAP, 40 % RCA-60 % RAP, and 20 % RCA-80 % RAP. A total of 16 beams (L: 1400 mm, W: 150 mm, H: 250 mm) and 128 cylinders (H: 200 m, D: 100 mm) were tested to evaluate the flexural capacity and material strength. Eight RC beams were tested after exposure to a temperature of 600 °C for 3 h. The compressive strength, ultimate flexural load, and mid-span deflection were measured. The results showed that temperature has an adverse effect on the s compressive strength, flexural load capacity, and deflection of RC beams. Specimens made with the RAP and RCA combination showed a significant loss in their load-carrying capacity under elevated temperature by (55 %–65 %), while the temperature effect was relatively less severe in specimens made with high RAP replacement of NA. Increasing the RAP percentage increased the reduction of flexural capacity in RCA-RAP mixes by (3 %–10 %), while in NA-RAP mixes, the effect is similar except for 60 % RAP, which has a smaller reduction compared to 40 % and 80 % RAP.
Published: 2024
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