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12 results on '"Naïmi, Mourad"'

7. [Nuclear FoxO1 as a bridge beetwen metabolism and mitogenesis.]

Author

Naïmi, Mourad, Van Obberghen, E., Laboratoire de biochimie, Hôpital Pasteur [Nice] (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), Dysfonctions métaboliques et diabètes: Mécanismes et approches thérapeutiques, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and Naïmi, Mourad

Subjects
endocrine system, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, nutritional and metabolic diseases, food and beverages, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, digestive system, hormones, hormone substitutes, and hormone antagonists
Abstract

National audience; The transcription factor FoxO1 plays a central role in the metabolic adaptations to fasting. Furthermore, FoxO1 and its homologs encode enzymes buffering ROS (reactive oxygen species) or repairing damaged DNA, and are involved in stalling the ageing process across evolution. Our recent work conducted in primary cultures of rat hepatocytes suggests new mechanisms by which Foxo1 exerts some of these functions. They revealed an unexpected role for Foxo1 in amplifying metabolic, survival, mitogenic and stress signals, and the existence of multiple feed-back loops by which Foxo1 integrates and controls these pathways. Furthermore, these effects were found to be independent of Foxo1 direct binding to DNA. double dagger.

Published
2008

9. Erratum: Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay

Author

Naïmi, Mourad, primary, Bannwarth, Sylvie, additional, Procaccio, Vincent, additional, Pouget, Jean, additional, Desnuelle, Claude, additional, Pellissier, Jean-François, additional, Rötig, Agnes, additional, Munnich, Arnold, additional, Calvas, Patrick, additional, Richelme, Christian, additional, Jonveaux, Philippe, additional, Castelnovo, Giovanni, additional, Simon, Mariella, additional, Clanet, Michel, additional, Wallace, Douglas, additional, and Paquis-Flucklinger, Véronique, additional

Published
2007
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10. Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay

Author

Naïmi, Mourad, primary, Bannwarth, Sylvie, additional, Procaccio, Vincent, additional, Pouget, Jean, additional, Desnuelle, Claude, additional, Pellissier, Jean-François, additional, Rötig, Agnes, additional, Munnich, Arnold, additional, Calvas, Patrick, additional, Richelme, Christian, additional, Jonveaux, Philippe, additional, Castelnovo, Giovanni, additional, Simon, Melvin, additional, Clanet, Michel, additional, Wallace, Douglas, additional, and Paquis-Flucklinger, Véronique, additional

Published
2006
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11. Inflammation: where is the SPARC in adipose-tissue inflammation?

Author

Naïmi, Mourad, Van Obberghen, Emmanuel, and Naïmi, Mourad

Subjects
*GLYCOPROTEINS, *ADIPOSE tissues, *INFLAMMATION, *INSULIN resistance, *EXTRACELLULAR matrix, *FIBRONECTINS, *CONNECTIVE tissue diseases, *ANIMALS
Abstract

The article discusses research on the role of a secreted protein, acidic, cysteine-rich (SPARC) glycoprotein in the growth of adipose-tissue and inflammation and insulin resistance. It references the study "Regulation of the Fibrosis and Angiogenesis Promoter SPARC/Osteonectin in Human Adipose Tissue by Weight Change, Leptin, Insulin and Glucose," by K. Kos et al in a 2009 issue of "Diabetes." The study cited the ability of SPARC to prevent adipogenesis by limiting the relationship between preadipocytes and extracellular matrix (ECM) with fibronectin.

Published
2009
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12. Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.

Author

Naïmi, Mourad, Bannwarth, Sylvie, Procaccio, Vincent, Pouget, Jean, Desnuelle, Claude, Pellissier, Jean-François, Rötig, Agnes, Munnich, Arnold, Calvas, Patrick, Richelme, Christian, Jonveaux, Philippe, Castelnovo, Giovanni, Simon, Mariella, Clanet, Michel, Wallace, Douglas, and Paquis-Flucklinger, Véronique

Subjects
*MITOCHONDRIAL DNA
Abstract

A correction to the article "Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay" that was published in a previous issue of the periodical is presented.

Published
2007
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