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5. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial

Author

Packer, M, Anker, S, Butler, J, Filippatos, G, Pocock, S, Zannad, F, Ferreira, JP, Brueckmann, M, George, J, Jamal, W, Welty, FK, Palmer, M, Clayton, T, Parhofer, KG, Pedersen, TR, Greenberg, B, Konstam, MA, Lees, KR, Carson, P, Doehner, W, Miller, A, Haas, M, Pehrson, S, Komajda, M, Anand, I, Teerlink, J, Rabinstein, A, Steiner, T, Kamel, H, Tsivgoulis, G, Lewis, J, Freston, J, Kaplowitz, N, Mann, J, Petrie, J, Perrone, S, Nicholls, S, Janssens, S, Bocchi, E, Giannetti, N, Verma, S, Zhang, J, Spinar, J, Seronde, M-F, Boehm, M, Merkely, B, Chopra, V, Senni, M, Taddi, S, Tsutsui, H, Choi, D-J, Chuquiure, E, La Rocca, HPB, Ponikowski, P, Juanatey, JRG, Squire, I, Januzzi, J, Pina, I, Bernstein, R, Cheung, A, Green, J, Kaul, S, Lam, C, Lip, G, Marx, N, McCullough, P, Mehta, C, Rosenstock, J, Sattar, N, Scirica, B, Shah, S, Wanner, C, Aizenberg, D, Cartasegna, L, Colombo Berra, F, Colombo, H, Fernandez Moutin, M, Glenny, J, Alvarez Lorio, C, Anauch, D, Campos, R, Facta, A, Fernandez, A, Ahuad Guerrero, R, Lobo Márquez, L, Leon de la Fuente, RA, Mansilla, M, Hominal, M, Hasbani, E, Najenson, M, Moises Azize, G, Luquez, H, Guzman, L, Sessa, H, Amuchástegui, M, Salomone, O, Perna, E, Piskorz, D, Sicer, M, Perez de Arenaza, D, Zaidman, C, Nani, S, Poy, C, Resk, J, Villarreal, R, Majul, C, Smith Casabella, T, Sassone, S, Liberman, A, Carnero, G, Caccavo, A, Berli, M, Budassi, N, Bono, J, Alvarisqueta, A, Amerena, J, Kostner, K, Hamilton, A, Begg, A, Beltrame, J, Colquhoun, D, Gordon, G, Sverdlov, A, Vaddadi, G, Wong, J, Coller, J, Prior, D, Friart, A, Leone, A, Vervoort, G, Timmermans, P, Troisfontaines, P, Franssen, C, Sarens, T, Vandekerckhove, H, Van De Borne, P, Chenot, F, De Sutter, J, De Vuyst, E, Debonnaire, P, Dupont, M, Pereira Dutra, O, Canani, LH, Vieira Moreira, MdC, de Souza, W, Backes, LM, Maia, L, De Souza Paolino, B, Manenti, ER, Saporito, W, Villaça Guimarães Filho, F, Franco Hirakawa, T, Saliba, LA, Neuenschwander, FC, de Freitas Zerbini, CA, Gonçalves, G, Gonçalves Mello, Y, Ascenção de Souza, J, Beck da Silva Neto, L, Bocchi, EA, Da Silveira, J, de Moura Xavier Moraes Junior, JB, de Souza Neto, JD, Hernandes, M, Finimundi, HC, Sampaio, CR, Vasconcellos, E, Neves Mancuso, FJ, Noya Rabelo, MM, Rodrigues Bacci, M, Santos, F, Vidotti, M, Simões, MV, Gomes, FL, Vieira Nascimento, C, Precoma, D, Helfenstein Fonseca, FA, Ribas Fortes, JA, Leães, PE, Campos de Albuquerque, D, Kerr Saraiva, JF, Rassi, S, Alves da Costa, FA, Reis, G, Zieroth, S, Dion, D, Savard, D, Bourgeois, R, Constance, C, Anderson, K, Leblanc, M-H, Yung, D, Swiggum, E, Pliamm, L, Pesant, Y, Tyrrell, B, Huynh, T, Spiegelman, J, Lavoie, J-P, Hartleib, M, Bhargava, R, Straatman, L, Virani, S, Costa-Vitali, A, Hill, L, Heffernan, M, Khaykin, Y, Ricci, J, Senaratne, M, Zhai, A, Lubelsky, B, Toma, M, Yao, L, McKelvie, R, Noronha, L, Babapulle, M, Pandey, A, Curnew, G, Lavoie, A, Berlingieri, J, Kouz, S, Lonn, E, Chehayeb, R, Zheng, Y, Sun, Y, Cui, H, Fan, Z, Han, X, Jiang, X, Tang, Q, Zhou, J, Zheng, Z, Zhang, X, Zhang, N, Zhang, Y, Shen, A, Yu, J, Ye, J, Yao, Y, Yan, J, Xu, X, Wang, Z, Ma, J, Li, Y, Li, S, Lu, S, Kong, X, Song, Y, Yang, G, Yao, Z, Pan, Y, Guo, X, Sun, Z, Dong, Y, Zhu, J, Peng, D, Yuan, Z, Lin, J, Yin, Y, Jerabek, O, Burianova, H, Fiala, T, Hubac, J, Ludka, O, Monhart, Z, Vodnansky, P, Zeman, K, Foldyna, D, Krupicka, J, Podpera, I, Busak, L, Radvan, M, Vomacka, Z, Prosecky, R, Cifkova, R, Durdil, V, Vesely, J, Vaclavik, J, Cervinka, P, Linhart, A, Brabec, T, Miklik, R, Bourhaial, H, Olbrich, H-G, Genth-Zotz, S, Kemala, E, Lemke, B, Böhm, M, Schellong, S, Rieker, W, Heitzer, T, Ince, H, Faghih, M, Birkenfeld, A, Begemann, A, Ghanem, A, Ujeyl, A, von Haehling, S, Dorsel, T, Bauersachs, J, Prull, M, Weidemann, F, Darius, H, Nickenig, G, Wilke, A, Sauter, J, Rauch-Kroehnert, U, Frey, N, Schulze, CP, König, W, Maier, L, Menzel, F, Proskynitopoulos, N, Ebert, H-H, Sarnighausen, H-E, Düngen, H-D, Licka, M, Stellbrink, C, Winkelmann, B, Menck, N, López-Sendón, JL, de la Fuente Galán, L, Delgado Jiménez, JF, Manito Lorite, N, Pérez de Juan Romero, M, Galve Basilio, E, Cereto Castro, F, González Juanatey, JR, Gómez, JJ, Sanmartín Fernández, M, Garcia-Moll Marimon, X, Pascual Figal, D, Bover Freire, R, Bonnefoy Cudraz, E, Jobbe Duval, A, Tomasevic, D, Habib, G, Isnard, R, Picard, F, Khanoyan, P, Dubois-Rande, J-L, Galinier, M, Roubille, F, Alexandre, J, Babuty, D, Delarche, N, Berneau, J-B, Girerd, N, Saxena, M, Rosano, G, Yousef, Z, Clifford, C, Arden, C, Bakhai, A, Boos, C, Jenkins, G, Travill, C, Price, D, Koenyves, L, Lakatos, F, Matoltsy, A, Noori, E, Zilahi, Z, Andrassy, P, Kancz, S, Simon, G, Sydo, T, Vorobcsuk, A, Kiss, RG, Toth, K, Szakal, I, Nagy, L, Barany, T, Nagy, A, Szolnoki, E, Chopra, VK, Mandal, S, Rastogi, V, Shah, B, Mullasari, A, Shankar, J, Mehta, V, Oomman, A, Kaul, U, Komarlu, S, Kahali, D, Bhagwat, A, Vijan, V, Ghaisas, NK, Mehta, A, Kashyap, J, Kothari, Y, TaddeI, S, Scherillo, M, Zacà, V, Genovese, S, Salvioni, A, Fucili, A, Fedele, F, Cosmi, F, Volpe, M, Mazzone, C, Esposito, G, Doi, M, Yamamoto, H, Sakagami, S, Oishi, S, Yasaka, Y, Tsuboi, H, Fujino, Y, Matsuoka, S, Watanabe, Y, Himi, T, Ide, T, Ichikawa, M, Kijima, Y, Koga, T, Yuda, S, Fukui, K, Kubota, T, Manita, M, Fujinaga, H, Matsumura, T, Fukumoto, Y, Kato, R, Kawai, Y, Hiasa, G, Kazatani, Y, Mori, M, Ogimoto, A, Inoko, M, Oguri, M, Kinoshita, M, Okuhara, K, Watanabe, N, Ono, Y, Otomo, K, Sato, Y, Matsunaga, T, Takaishi, A, Miyagi, N, Uehara, H, Takaishi, H, Urata, H, Kataoka, T, Matsubara, H, Matsumoto, T, Suzuki, T, Takahashi, N, Imamaki, M, Yoshitama, T, Saito, T, Sekino, H, Furutani, Y, Koda, M, Shinozaki, T, Hirabayashi, K, Tsunoda, R, Yonezawa, K, Hori, H, Yagi, M, Arikawa, M, Hashizume, T, Ishiki, R, Koizumi, T, Nakayama, K, Taguchi, S, Nanasato, M, Yoshida, Y, Tsujiyama, S, Nakamura, T, Oku, K, Shimizu, M, Suwa, M, Momiyama, Y, Sugiyama, H, Kobayashi, K, Inoue, S, Kadokami, T, Maeno, K, Kawamitsu, K, Maruyama, Y, Nakata, A, Shibata, T, Wada, A, Cho, H-J, Na, JO, Yoo, B-S, Choi, J-O, Hong, SK, Shin, J-H, Cho, M-C, Han, SH, Jeong, J-O, Kim, J-J, Kang, SM, Kim, D-S, Kim, MH, Llamas Esperon, G, Illescas Díaz, J, Fajardo Campos, P, Almeida Alvarado, J, Bazzoni Ruiz, A, Echeverri Rico, J, Lopez Alcocer, I, Valle Molina, L, Hernandez Herrera, C, Calvo Vargas, C, Padilla Padilla, FG, Rodriguez Briones, I, Chuquiure Valenzuela, EJJR, Aguilera Real, ME, Carrillo Calvillo, J, Alpizar Salazar, M, Cervantes Escárcega, JL, Velasco Sanchez, R, Al - Windy, N, van Heerebeek, L, Bellersen, L, Brunner-La Rocca, H-P, Post, J, Linssen, GCM, van de Wetering, M, Peters, R, van Stralen, R, Groutars, R, Smits, P, Yilmaz, A, Kok, WEM, Van der Meer, P, Dijkmans, P, Troquay, R, van Alem, AP, Van de Wal, R, Handoko, L, Westendorp, ICD, van Bergen, PFMM, Rensing, BJWM, Hoogslag, P, Kietselaer, B, Kragten, JA, den Hartog, FR, Alings, A, Danilowicz-Szymanowicz, L, Raczak, G, Piesiewicz, W, Zmuda, W, Kus, W, Podolec, P, Musial, W, Drelich, G, Kania, G, Miekus, P, Mazur, S, Janik, A, Spyra, J, Peruga, J, Balsam, P, Krakowiak, B, Szachniewicz, J, Ginel, M, Grzybowski, J, Chrustowski, W, Wojewoda, P, Kalinka, A, Zurakowski, A, Koc, R, Debinski, M, Fil, W, Kujawiak, M, Forys, J, Kasprzak, M, Krol, M, Michalski, P, Mirek-Bryniarska, E, Radwan, K, Skonieczny, G, Stania, K, Skoczylas, G, Madej, A, Jurowiecki, J, Firek, B, Wozakowska-Kaplon, B, Cymerman, K, Neutel, J, Adams, K, Balfour, P, Deswal, A, Djamson, A, Duncan, P, Hong, M, Murray, C, Rinde-Hoffman, D, Woodhouse, S, MacNevin, R, Rama, B, Broome-Webster, C, Kindsvater, S, Abramov, D, Barettella, M, Pinney, S, Herre, J, Cohen, A, Vora, K, Challappa, K, West, S, Baum, S, Cox, J, Jani, S, Karim, A, Akhtar, A, Quintana, O, Paukman, L, Goldberg, R, Bhatti, Z, Budoff, M, Bush, E, Potler, A, Delgado, R, Ellis, B, Dy, J, Fialkow, J, Sangrigoli, R, Ferdinand, K, East, C, Falkowski, S, Donahoe, S, Ebrahimi, R, Kline, G, Harris, B, Khouzam, R, Jaffrani, N, Jarmukli, N, Kazemi, N, Koren, M, Friedman, K, Herzog, W, Silva Enciso, J, Cheung, D, Grover-McKay, M, Hauptman, P, Mikhalkova, D, Hegde, V, Hodsden, J, Khouri, S, McGrew, F, Littlefield, R, Bradley, P, McLaurin, B, Lupovitch, S, Labin, I, Rao, V, Leithe, M, Lesko, M, Lewis, N, Lombardo, D, Mahal, S, Malhotra, V, Dauber, I, Banerjee, A, Needell, J, Miller, G, Paladino, L, Munuswamy, K, Nanna, M, McMillan, E, Mumma, M, Napoli, M, Nelson, W, O'Brien, T, Adlakha, A, Onwuanyi, A, Serota, H, Schmedtje, J, Paraschos, A, Potu, R, Sai-Sudhakar, C, Saltzberg, M, Sauer, A, Shah, P, Skopicki, H, Bui, H, Carr, K, Stevens, G, Tahirkheli, N, Tallaj, J, Yousuf, K, Trichon, B, Welker, J, Tolerico, P, Vest, A, Vivo, R, Wang, X, Abadier, R, Dunlap, S, Weintraub, N, Malik, A, Kotha, P, Zaha, V, Kim, G, Uriel, N, Greene, T, Salacata, A, Arora, R, Gazmuri, R, Kobayashi, J, Iteld, B, Vijayakrishnan, R, Dab, R, Mirza, Z, Marques, V, Nallasivan, M, Bensimhon, D, Peart, B, Saint-Jacques, H, Barringhaus, K, Contreras, J, Gupta, A, Koneru, S, Nguyen, V, Verma, Subodh, Dhingra, Nitish K, Butler, Javed, Anker, Stefan D, Ferreira, Joao Pedro, Filippatos, Gerasimos, Januzzi, James L, Lam, Carolyn S P, Sattar, Naveed, Peil, Barbara, Nordaby, Matias, Brueckmann, Martina, Pocock, Stuart J, Zannad, Faiez, and Packer, Milton

Published
2022
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6. An Effective Staff Scheduling for Shift Workers in Social Welfare Facilities for the Disabled

Author

Hee Jun Ryu, Ye Na Jo, Won Jun Lee, Ji Won Cheong, Boo Yong Moon, and Young Dae Ko

Subjects
social worker, job satisfaction, staff scheduling, mathematical model, operations research, optimization, Industrial engineering. Management engineering, T55.4-60.8, Electronic computers. Computer science, QA75.5-76.95
Abstract

The efficient management of social worker personnel is important since it involves a huge portion in its operations. However, the burnout and turnover rates of social workers are very high, which is due to dissatisfaction with the irregular and unequal schedules, despite the continuous improvement in the treatment of social workers and the enactment of work-related legislation in Korea. This means that changes in policy do not significantly contribute to improving worker satisfaction, which shows the necessity of the strategies to prevent the turnover of workers. Therefore, this study aims to propose a strategy for the staff scheduling of workers that considers the fairness in the shift distribution among workers and the individual preference for shift work by using the linear programming. A survey about the preferences for shift work is conducted that targeted the employees of a welfare facility in Korea to enhance the practicality of the model. The effectiveness and applicability of the developed mathematical model are verified by deriving a deterministic schedule for a worker via the system parameters that were obtained based on the survey and the rules of the welfare facility in the numerical experiment. Compared to the conventional schedule, the derived schedule shows an improvement in the deviations in the number of shifts workers and a reflection of the personal preferences. This can raise the social worker’s satisfaction, which will decrease intention on burnouts and turnover. It will consequently facilitate on managing human resources in welfare facilities.

Published
2023
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7. Prediction of first acute exacerbation using COPD subtypes identified by cluster analysis

Author

Yoon HY, Park SY, Lee CH, Byun MK, Na JO, Lee JS, Lee WY, Yoo KH, Jung KS, and Lee JH

Subjects
Clustering, Prognosis, Phenotype, asthma-COPD overlap, Exacerbation, Comorbidity, Diseases of the respiratory system, RC705-779
Abstract

Hee-Young Yoon,1 So Young Park,1 Chang Hoon Lee,2 Min-Kwang Byun,3 Joo Ock Na,4 Jae Seung Lee,5 Won-Yeon Lee,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Jin Hwa Lee11Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans Seoul Hospital, Ewha Womans University, Seoul, Korea; 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea; 3Division of Pulmonary Medicine, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea; 4Division of Pulmonology, Department of Internal Medicine, Soonchunhyang University, College of Medicine, Cheonan, Korea; 5Department of Pulmonary and Critical Care Medicine, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Korea; 6Department of Internal Medicine, Wonju Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea; 7Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea; 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, KoreaPurpose: In patients with COPD, acute exacerbation (AE) is not only an important determinant of prognosis, but also an important factor in choosing therapeutic agents. In this study, we evaluated the usefulness of COPD subtypes identified through cluster analysis to predict the first AE. Patients and methods: Among COPD patients in the Korea COPD Subgroup Study (KOCOSS) cohort, 1,195 who had follow-up data for AE were included in our study. We selected seven variables for cluster analysis – age, body mass index, smoking status, history of asthma, COPD assessment test (CAT) score, post-bronchodilator (BD) FEV1 % predicted, and diffusing capacity of carbon monoxide % predicted. Results: K-means clustering identified four clusters for COPD that we named putative asthma-COPD overlap (ACO), mild COPD, moderate COPD, and severe COPD subtypes. The ACO group (n=196) showed the second-best post-BD FEV1 (75.5% vs 80.9% [mild COPD, n=313] vs 52.4% [moderate COPD, n=345] vs 46.7% [severe COPD, n=341] predicted), the longest 6-min walking distance (424 m vs 405 m vs 389 m vs 365 m), and the lowest CAT score (12.2 vs 13.7 vs 15.6 vs 17.5) among the four groups. ACO group had greater risk for first AE compared to the mild COPD group (HR, 1.683; 95% CI, 1.175–2.410). The moderate COPD and severe COPD group HR values were 1.587 (95% CI, 1.145–2.200) and 1.664 (95% CI, 1.203–2.302), respectively. In addition, St. George’s Respiratory Questionnaire score (HR: 1.019; 95% CI, 1.014–1.024) and gastroesophageal reflux disease were independent factors associated with the first AE (HR: 1.535; 95% CI, 1.116–2.112). Conclusion: Our cluster analysis revealed an exacerbator subtype of COPD independent of FEV1. Since these patients are susceptible to AE, a more aggressive treatment strategy is needed in these patients.Keywords: clustering, prognosis, phenotype, asthma-COPD overlap, exacerbation, comorbidity

Published
2019

8. ROCK and PDE-5 Inhibitors for the Treatment of Dementia: Literature Review and Meta-Analysis

Author

Dong-Hun Lee, Ji Young Lee, Dong-Yong Hong, Eun Chae Lee, Sang-Won Park, Yu Na Jo, Yu Jin Park, Jae Young Cho, Yoo Jin Cho, Su Hyun Chae, Man Ryul Lee, and Jae Sang Oh

Subjects
Alzheimer’s disease, cGMP, ERM, LIMK, meta-analysis, MLC, Biology (General), QH301-705.5
Abstract

Dementia is a disease in which memory, thought, and behavior-related disorders progress gradually due to brain damage caused by injury or disease. It is mainly caused by Alzheimer’s disease or vascular dementia and several other risk factors, including genetic factors. It is difficult to treat as its incidence continues to increase worldwide. Many studies have been performed concerning the treatment of this condition. Rho-associated kinase (ROCK) and phosphodiesterase-5 (PDE-5) are attracting attention as pharmacological treatments to improve the symptoms. This review discusses how ROCK and PDE-5 affect Alzheimer’s disease, vascular restructuring, and exacerbation of neuroinflammation, and how their inhibition helps improve cognitive function. In addition, the results of the animal behavior analysis experiments utilizing the Morris water maze were compared through meta-analysis to analyze the effects of ROCK inhibitors and PDE-5 inhibitors on cognitive function. According to the selection criteria, 997 publications on ROCK and 1772 publications on PDE-5 were screened, and conclusions were drawn through meta-analysis. Both inhibitors showed good improvement in cognitive function tests, and what is expected of the synergy effect of the two drugs was confirmed in this review.

Published
2022
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9. Viral Load as a Factor Affecting the Fatality of Patients Suffering from Severe Fever with Thrombocytopenia Syndrome

Author

Heyon-Na Jo, Jieun Kim, Seong-Yeon Hwang, Jun-Won Seo, Da Young Kim, Na-Ra Yun, Dong-Min Kim, Choon-Mee Kim, Sook In Jung, Uh Jin Kim, Seong Eun Kim, Hyunah Kim, Eu Suk Kim, Jian Hur, Young Keun Kim, Hye Won Jeong, Jung Yeon Heo, Dong Sik Jung, Hyungdon Lee, Sun Hee Park, Yee Gyung Kwak, Sujin Lee, and Seungjin Lim

Subjects
SFTS phlebovirus, viral RNA load, mortality, Microbiology, QR1-502
Abstract

The clinical characteristics and the effect of viral RNA loads on fatality in 56 patients with severe fever with thrombocytopenia syndrome (SFTS) were analyzed. The non-survival group (12 patients) demonstrated a significantly higher mean age (77 years) than the survival group (44 patients, 65 years) (p = 0.003). The survival rates were 91.7% and 8.3% in patients with Ct values ≥30 and differed significantly (p = 0.001) in the survival and non-survival groups, respectively. The survival rates were 52.4% and 47.6% in patients with viral copy numbers ≥10,000 and 94.3% and 5.7% in patients with viral copy numbers p = 0.001). In a multivariate analysis, viral copy numbers and initial Acute Psychologic Assessment and Chronic Health Evaluation II (APACHE II) scores were identified as the factors affecting fatality (p = 0.015 and 0.011, respectively). SFTS viral RNA loads can be useful markers for the clinical prediction of mortality and survival.

Published
2022
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10. Studies on Preformulation and Formulation of JIN-001 Liquisolid Tablet with Enhanced Solubility

Author

Han-Sol Kim, Chang-Min Kim, An-Na Jo, and Joo-Eun Kim

Subjects
JIN-001, heat shock protein 90 inhibitor, capryol 90, colloidal silicon dioxide, liquisolid, solubility, Medicine, Pharmacy and materia medica, RS1-441
Abstract

This study aimed to develop a heat shock protein 90 (Hsp90) inhibitor liquisolid tablet with improved solubility to overcome low bioavailability issues. As an active pharmaceutical ingredient (API), JIN-001, a novel Hsp90 inhibitor, was reported to have substantial in vitro antiproliferative and in vivo antitumor activity; however, JIN-001 was a crystalline solid with very low solubility in an aqueous solution, and therefore, Capryol 90, which has excellent solubilization ability, was selected as an optimal liquid vehicle based on solubility studies. JIN-001 liquisolid (JLS) powder was successfully prepared by dissolving JIN-001 in Capryol 90 and mixing colloidal silicon dioxide (CSD) used as an oil adsorption agent. The prepared JLS was confirmed to be amorphous. Based on the result of the solubility test of JLS, compared to JIN-001, the solubility of the former was significantly improved in all solvents regardless of pH. JLS tablets were prepared through wet granulation using JIN-001 and stable excipients based on the compatibility test. The developed JLS tablet significantly increased the drug release rate in all tested solutions; however, the liquisolid method had no significant effect on bioavailability in the pharmacokinetics study in beagle dogs. In conclusion, the liquisolid system influenced the solubility and dissolution rate of JIN-001.

Published
2022
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11. Which GOLD B patients progress to GOLD D with the new classification?

Author

Choi HS, Na JO, Lee JD, Shin KC, Rhee CK, Hwang YI, Lim SY, Yoo KH, Jung KS, and Park YB

Subjects
COPD, GOLD B, Progression, Diseases of the respiratory system, RC705-779
Abstract

Hye Sook Choi,1 Ju Ock Na,2 Jong Deog Lee,3 Kyeong-Cheol Shin,4 Chin Kook Rhee,5 Yong Il Hwang,6 Seong Yong Lim,7 Kwang Ha Yoo,8 Ki Suck Jung,6 Yong Bum Park9 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kyunghee University Hospital, Seoul, Republic of Korea; 2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Pulmonary Medicine, Soonchunhyang University Cheonan Hospital, Cheonan-si, Republic of Korea; 3Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University, Jinju, Republic of Korea; 4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Republic of Korea; 5Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea; 6Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Republic of Korea; 9Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea Background: The 2017 GOLD guidelines revised assessment of COPD by eliminating the FEV1 criterion.Aim: First, we explored the redistribution of 2011 GOLD groups by reference to the 2017 GOLD criteria. Second, we investigated the characteristics of GOLD B patients and the natural course of GOLD B patients according to the 2017 GOLD guidelines.Methods: In total, 2,010 COPD patients in the Korean COPD Subgroup Study cohort were analyzed at baseline and 1 year after enrollment.Results: The 2011 GOLD C patients were redistributed to the 2017 A (64.5%) and C (35.4%) groups. The 2011 GOLD D patients were redistributed to the 2017 B (61.6%) and D (38.6%) groups. The GOLD B patients constituted 62.7% of all patients according to the 2017 classification. Such patients exhibited higher % predicted FEV1 values, longer six-minute walk distances, fewer symptoms, and lower inflammatory marker levels than GOLD D patients. Most GOLD B patients remained in that group (69.1%), but 13.8% progressed to group D at 1-year follow-up. The factors associated with progression from GOLD B to GOLD D were older age, higher modified Medical Research Council (mMRC) and St George’s Respiratory Questionnaire (SGRQ) symptom scores, and a lower % predicted FEV1 value.Conclusion: Severe symptoms, poorer health status, and greater airflow limitation increased patients’ risk of exacerbation and progression from group B to group D when the 2017 GOLD criteria were applied. Keywords: COPD, GOLD B, progression

Published
2018

13. Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

Author

Choi JY, Yoon HK, Park SJ, Park YB, Shin KC, Na JO, Yoo KH, Jung KS, Kim YK, and Rhee CK

Subjects
chronic obstructive pulmonary disease, chronic bronchitis, COPD assessment test, Diseases of the respiratory system, RC705-779
Abstract

Joon Young Choi,1 Hyoung Kyu Yoon,2 Seoung Ju Park,3 Yong Bum Park,4 Kyeong-Cheol Shin,5 Ju Ock Na,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Young Kyoon Kim,1 Chin Kook Rhee1 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, 4Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, 5Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, 6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea Background: The chronic bronchitis (CB) phenotype has been associated with poor quality of life and an increased risk of disease in patients with COPD. However, little information exists regarding the relationship between the CB phenotype and the COPD assessment test (CAT) score. The goal of this study was to reveal the different pattern of CAT scores between CB and non-CB patients. Moreover, we aimed to investigate whether the CB phenotype is an independently associated factor for more symptom and high-risk groups.Methods: Data were obtained from the Korea COPD Subgroup Study cohort recruited from 46 centers in South Korea since April 2012. CB patients were defined as having a chronic cough and sputum for 3 months per year, for a period of 2 consecutive years. We investigated the pattern of CAT and subquestionnaire scores between CB and non-CB patients. We also analyzed the proportion of CB phenotypes in each Global initiative for chronic Obstructive Lung Disease (GOLD) stage. Finally, we performed a logistic regression analysis to identify whether the CB phenotype was an independently associated factor for more symptom and high-risk groups.Results: Of the 1,106 study patients, 11.5% of patients were found to have a CB phenotype. CB phenotypes were most common in GOLD III (GOLD 2006) and GOLD D (GOLD 2015) stages. CAT scores were significantly higher in CB patients not only in terms of the total score but also for each subquestionnaire. Logistic regression revealed that the CB phenotype is an independently associated factor for more symptom and high-risk groups.Conclusion: The present study revealed that CB patients have higher CAT scores and subquestionnaire results compared to non-CB patients. Additionally, we demonstrated that the CB phenotype is an independently associated factor for both more symptom and high-risk groups. Keywords: chronic obstructive pulmonary disease, chronic bronchitis, COPD assess­ment test

Published
2016

18. Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3

Author

Kyung Hoon Chang, Mi Na Jo, Kee-Tae Kim, and Hyun-Dong Paik

Subjects
Aspergillus niger, β-glucosidase, ginsenoside Rg3, Panax ginseng, transformation, Botany, QK1-989
Abstract

The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography were evaluated to develop a new biologically active material. The conversion of ginsenoside Rb1 generated Rd, Rg3, Rh2, and compound K although the reaction rates were low due to the low concentration. In enzymatic conversion, all of the ginsenoside Rb1 was converted to ginsenoside Rd and ginsenoside Rg3 after 24 h of incubation. The crude enzyme (β-glucosidase) from A. niger KCCM 11239 hydrolyzed the β-(1→6)-glucosidic linkage at the C-20 of ginsenoside Rb1 to generate ginsenoside Rd and ginsenoside Rg3. Our experimental demonstration showing that A. niger KCCM 11239 produces the ginsenoside-hydrolyzing β-glucosidase reflects the feasibility of developing a specific bioconversion process to obtain active minor ginsenosides.

Published
2014
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22. Production of protein hydrolysate from Protaetia brevitarsis seulensis (Kolbe) larvae by enzyme treatment under high pressure

Author

Young-Jae Song, So-Jin Lee, Seong-Oh Kim, YongJin Cho, Mi-Na Jo, Yong-Deok Jeon, Hyeon-Jae Sim, Chong-Tai Kim, Hoon-Yeon Lee, Jong-Sik Jin, Dong-Keun Kim, and Tae-eun Kim

Subjects
0106 biological sciences, chemistry.chemical_classification, Larva, Atmospheric pressure, Extraction (chemistry), 04 agricultural and veterinary sciences, 040401 food science, 01 natural sciences, Applied Microbiology and Biotechnology, Article, Hydrolysate, Amino acid, 0404 agricultural biotechnology, Enzyme, chemistry, 010608 biotechnology, Enzymatic hydrolysis, Yield (chemistry), Food science, Food Science, Biotechnology
Abstract

To improve the industrial use of health-functional materials based on edible insects, the objective of this study was to establish optimal conditions for improving the quality of Protaetia brevitarsis seulensis larval (PBSL) hydrolysates. PBSL was extracted using four methodologies: atmospheric pressure 50 °C-water extraction, atmospheric pressure 95 °C-water extraction, atmospheric pressure 50 °C-water enzymatic hydrolysis, and enzyme treatment under high pressure (HPE). The quality characteristics of soluble solid content, extraction yield, total protein content, protein yield, protein content with low molecular weight (LMW) (

Published
2020

23. Schlieren visualization of micro gas turbine exhaust plume with different shapes of nozzle

Author

Ha Na Jo, Jae Won Kim, Jeong Seok Lee, Seong Man Choi, and Rho-Shin Myong

Subjects
Flow visualization, Materials science, Nozzle, Exhaust gas, 020207 software engineering, 02 engineering and technology, Mechanics, Propelling nozzle, Condensed Matter Physics, 01 natural sciences, Turbine, Aspect ratio (image), 010305 fluids & plasmas, Plume, Schlieren, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering
Abstract

Schlieren visualization of the plume ejected from the microgas turbine nozzle was conducted to understand infrared signal characteristics of various shapes of the exhaust nozzle. At the same time, the precise temperature distribution and infrared signal measurement were performed and compared. The maximum thrust of the microgas turbine used in the experiment is 230 N, the maximum speed of revolution is 108,500 rpm, and the maximum exhaust gas temperature is 750 °C. Seven nozzles were used for this experiment which included a cone nozzle, five square nozzles with aspect ratios (AR) ranging from 1 to 5 and an S-shaped nozzle with aspect ratio 6. The infrared signal emitted from the exhaust plume decreased as the aspect ratio increased. Schlieren flow visualization images show that cone nozzle had a uniform flow pattern, while square nozzle had a bright triangle pattern in the dispersed plume. As the aspect ratio of square nozzles increased, a bright triangle pattern reduced in size. On comparing Schlieren visualization with the temperature distribution, it can be understood that the triangular shape of core plume plays a major role in the temperature diffusion with the surrounding air. Based on the temperature distribution and the results of the Schlieren visualization, three types of exhaust plume models are suggested. These three models are homogenous plume, intermediate plume and two-dimensional plume with hot core, which correspond to the cone nozzle, the AR2 square nozzle and AR5 square nozzle, respectively.

Published
2020

26. Enzymatic Hydrolysis of Egg White Protein Exerts a Hypotensive Effect in Spontaneously Hypertensive Rats

Author

Yu-Na Jo, Sung-Seob Yun, Tae-Hwan Jung, Da-Eon Lee, and Kyoung-Sik Han

Subjects
medicine.medical_specialty, hypotensive effect, Diastole, angiotensin II, Article, Hydrolysate, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, nitric oxide, Enzymatic hydrolysis, Internal medicine, medicine, Ingestion, Food science, Chemistry, 0402 animal and dairy science, 04 agricultural and veterinary sciences, egg white protein hydrolysate, 040201 dairy & animal science, Angiotensin II, Papain, Endocrinology, 030221 ophthalmology & optometry, Animal Science and Zoology, spontaneously hypertensive rats, Food Science, Egg white
Abstract

This study was conducted to investigate the hypotensive effect of egg white protein (EWP) hydrolysate (EWH) in spontaneously hypertensive rats (SHRs). The hydrolysis of EWP was effectively performed with a combination of 0.5% bromelain and 1% papain at 50°C for 60 min. The resulting hydrolysate did not elicit an allergic reaction as confirmed by human mast cell activation test. The systolic and diastolic blood pressures of the SHRs fed the EWH diet were observed to be significantly or numerically lower than those of the other groups during the experimental period of 28 d. EWH treatment significantly (p

Published
2019

27. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial

Author

Verma, Subodh, primary, Dhingra, Nitish K, additional, Butler, Javed, additional, Anker, Stefan D, additional, Ferreira, Joao Pedro, additional, Filippatos, Gerasimos, additional, Januzzi, James L, additional, Lam, Carolyn S P, additional, Sattar, Naveed, additional, Peil, Barbara, additional, Nordaby, Matias, additional, Brueckmann, Martina, additional, Pocock, Stuart J, additional, Zannad, Faiez, additional, Packer, Milton, additional, Packer, M, additional, Anker, S, additional, Butler, J, additional, Filippatos, G, additional, Pocock, S, additional, Zannad, F, additional, Ferreira, JP, additional, Brueckmann, M, additional, George, J, additional, Jamal, W, additional, Welty, FK, additional, Palmer, M, additional, Clayton, T, additional, Parhofer, KG, additional, Pedersen, TR, additional, Greenberg, B, additional, Konstam, MA, additional, Lees, KR, additional, Carson, P, additional, Doehner, W, additional, Miller, A, additional, Haas, M, additional, Pehrson, S, additional, Komajda, M, additional, Anand, I, additional, Teerlink, J, additional, Rabinstein, A, additional, Steiner, T, additional, Kamel, H, additional, Tsivgoulis, G, additional, Lewis, J, additional, Freston, J, additional, Kaplowitz, N, additional, Mann, J, additional, Petrie, J, additional, Perrone, S, additional, Nicholls, S, additional, Janssens, S, additional, Bocchi, E, additional, Giannetti, N, additional, Verma, S, additional, Zhang, J, additional, Spinar, J, additional, Seronde, M-F, additional, Boehm, M, additional, Merkely, B, additional, Chopra, V, additional, Senni, M, additional, Taddi, S, additional, Tsutsui, H, additional, Choi, D-J, additional, Chuquiure, E, additional, La Rocca, HPB, additional, Ponikowski, P, additional, Juanatey, JRG, additional, Squire, I, additional, Januzzi, J, additional, Pina, I, additional, Bernstein, R, additional, Cheung, A, additional, Green, J, additional, Kaul, S, additional, Lam, C, additional, Lip, G, additional, Marx, N, additional, McCullough, P, additional, Mehta, C, additional, Rosenstock, J, additional, Sattar, N, additional, Scirica, B, additional, Shah, S, additional, Wanner, C, additional, Aizenberg, D, additional, Cartasegna, L, additional, Colombo Berra, F, additional, Colombo, H, additional, Fernandez Moutin, M, additional, Glenny, J, additional, Alvarez Lorio, C, additional, Anauch, D, additional, Campos, R, additional, Facta, A, additional, Fernandez, A, additional, Ahuad Guerrero, R, additional, Lobo Márquez, L, additional, Leon de la Fuente, RA, additional, Mansilla, M, additional, Hominal, M, additional, Hasbani, E, additional, Najenson, M, additional, Moises Azize, G, additional, Luquez, H, additional, Guzman, L, additional, Sessa, H, additional, Amuchástegui, M, additional, Salomone, O, additional, Perna, E, additional, Piskorz, D, additional, Sicer, M, additional, Perez de Arenaza, D, additional, Zaidman, C, additional, Nani, S, additional, Poy, C, additional, Resk, J, additional, Villarreal, R, additional, Majul, C, additional, Smith Casabella, T, additional, Sassone, S, additional, Liberman, A, additional, Carnero, G, additional, Caccavo, A, additional, Berli, M, additional, Budassi, N, additional, Bono, J, additional, Alvarisqueta, A, additional, Amerena, J, additional, Kostner, K, additional, Hamilton, A, additional, Begg, A, additional, Beltrame, J, additional, Colquhoun, D, additional, Gordon, G, additional, Sverdlov, A, additional, Vaddadi, G, additional, Wong, J, additional, Coller, J, additional, Prior, D, additional, Friart, A, additional, Leone, A, additional, Vervoort, G, additional, Timmermans, P, additional, Troisfontaines, P, additional, Franssen, C, additional, Sarens, T, additional, Vandekerckhove, H, additional, Van De Borne, P, additional, Chenot, F, additional, De Sutter, J, additional, De Vuyst, E, additional, Debonnaire, P, additional, Dupont, M, additional, Pereira Dutra, O, additional, Canani, LH, additional, Vieira Moreira, MdC, additional, de Souza, W, additional, Backes, LM, additional, Maia, L, additional, De Souza Paolino, B, additional, Manenti, ER, additional, Saporito, W, additional, Villaça Guimarães Filho, F, additional, Franco Hirakawa, T, additional, Saliba, LA, additional, Neuenschwander, FC, additional, de Freitas Zerbini, CA, additional, Gonçalves, G, additional, Gonçalves Mello, Y, additional, Ascenção de Souza, J, additional, Beck da Silva Neto, L, additional, Bocchi, EA, additional, Da Silveira, J, additional, de Moura Xavier Moraes Junior, JB, additional, de Souza Neto, JD, additional, Hernandes, M, additional, Finimundi, HC, additional, Sampaio, CR, additional, Vasconcellos, E, additional, Neves Mancuso, FJ, additional, Noya Rabelo, MM, additional, Rodrigues Bacci, M, additional, Santos, F, additional, Vidotti, M, additional, Simões, MV, additional, Gomes, FL, additional, Vieira Nascimento, C, additional, Precoma, D, additional, Helfenstein Fonseca, FA, additional, Ribas Fortes, JA, additional, Leães, PE, additional, Campos de Albuquerque, D, additional, Kerr Saraiva, JF, additional, Rassi, S, additional, Alves da Costa, FA, additional, Reis, G, additional, Zieroth, S, additional, Dion, D, additional, Savard, D, additional, Bourgeois, R, additional, Constance, C, additional, Anderson, K, additional, Leblanc, M-H, additional, Yung, D, additional, Swiggum, E, additional, Pliamm, L, additional, Pesant, Y, additional, Tyrrell, B, additional, Huynh, T, additional, Spiegelman, J, additional, Lavoie, J-P, additional, Hartleib, M, additional, Bhargava, R, additional, Straatman, L, additional, Virani, S, additional, Costa-Vitali, A, additional, Hill, L, additional, Heffernan, M, additional, Khaykin, Y, additional, Ricci, J, additional, Senaratne, M, additional, Zhai, A, additional, Lubelsky, B, additional, Toma, M, additional, Yao, L, additional, McKelvie, R, additional, Noronha, L, additional, Babapulle, M, additional, Pandey, A, additional, Curnew, G, additional, Lavoie, A, additional, Berlingieri, J, additional, Kouz, S, additional, Lonn, E, additional, Chehayeb, R, additional, Zheng, Y, additional, Sun, Y, additional, Cui, H, additional, Fan, Z, additional, Han, X, additional, Jiang, X, additional, Tang, Q, additional, Zhou, J, additional, Zheng, Z, additional, Zhang, X, additional, Zhang, N, additional, Zhang, Y, additional, Shen, A, additional, Yu, J, additional, Ye, J, additional, Yao, Y, additional, Yan, J, additional, Xu, X, additional, Wang, Z, additional, Ma, J, additional, Li, Y, additional, Li, S, additional, Lu, S, additional, Kong, X, additional, Song, Y, additional, Yang, G, additional, Yao, Z, additional, Pan, Y, additional, Guo, X, additional, Sun, Z, additional, Dong, Y, additional, Zhu, J, additional, Peng, D, additional, Yuan, Z, additional, Lin, J, additional, Yin, Y, additional, Jerabek, O, additional, Burianova, H, additional, Fiala, T, additional, Hubac, J, additional, Ludka, O, additional, Monhart, Z, additional, Vodnansky, P, additional, Zeman, K, additional, Foldyna, D, additional, Krupicka, J, additional, Podpera, I, additional, Busak, L, additional, Radvan, M, additional, Vomacka, Z, additional, Prosecky, R, additional, Cifkova, R, additional, Durdil, V, additional, Vesely, J, additional, Vaclavik, J, additional, Cervinka, P, additional, Linhart, A, additional, Brabec, T, additional, Miklik, R, additional, Bourhaial, H, additional, Olbrich, H-G, additional, Genth-Zotz, S, additional, Kemala, E, additional, Lemke, B, additional, Böhm, M, additional, Schellong, S, additional, Rieker, W, additional, Heitzer, T, additional, Ince, H, additional, Faghih, M, additional, Birkenfeld, A, additional, Begemann, A, additional, Ghanem, A, additional, Ujeyl, A, additional, von Haehling, S, additional, Dorsel, T, additional, Bauersachs, J, additional, Prull, M, additional, Weidemann, F, additional, Darius, H, additional, Nickenig, G, additional, Wilke, A, additional, Sauter, J, additional, Rauch-Kroehnert, U, additional, Frey, N, additional, Schulze, CP, additional, König, W, additional, Maier, L, additional, Menzel, F, additional, Proskynitopoulos, N, additional, Ebert, H-H, additional, Sarnighausen, H-E, additional, Düngen, H-D, additional, Licka, M, additional, Stellbrink, C, additional, Winkelmann, B, additional, Menck, N, additional, López-Sendón, JL, additional, de la Fuente Galán, L, additional, Delgado Jiménez, JF, additional, Manito Lorite, N, additional, Pérez de Juan Romero, M, additional, Galve Basilio, E, additional, Cereto Castro, F, additional, González Juanatey, JR, additional, Gómez, JJ, additional, Sanmartín Fernández, M, additional, Garcia-Moll Marimon, X, additional, Pascual Figal, D, additional, Bover Freire, R, additional, Bonnefoy Cudraz, E, additional, Jobbe Duval, A, additional, Tomasevic, D, additional, Habib, G, additional, Isnard, R, additional, Picard, F, additional, Khanoyan, P, additional, Dubois-Rande, J-L, additional, Galinier, M, additional, Roubille, F, additional, Alexandre, J, additional, Babuty, D, additional, Delarche, N, additional, Berneau, J-B, additional, Girerd, N, additional, Saxena, M, additional, Rosano, G, additional, Yousef, Z, additional, Clifford, C, additional, Arden, C, additional, Bakhai, A, additional, Boos, C, additional, Jenkins, G, additional, Travill, C, additional, Price, D, additional, Koenyves, L, additional, Lakatos, F, additional, Matoltsy, A, additional, Noori, E, additional, Zilahi, Z, additional, Andrassy, P, additional, Kancz, S, additional, Simon, G, additional, Sydo, T, additional, Vorobcsuk, A, additional, Kiss, RG, additional, Toth, K, additional, Szakal, I, additional, Nagy, L, additional, Barany, T, additional, Nagy, A, additional, Szolnoki, E, additional, Chopra, VK, additional, Mandal, S, additional, Rastogi, V, additional, Shah, B, additional, Mullasari, A, additional, Shankar, J, additional, Mehta, V, additional, Oomman, A, additional, Kaul, U, additional, Komarlu, S, additional, Kahali, D, additional, Bhagwat, A, additional, Vijan, V, additional, Ghaisas, NK, additional, Mehta, A, additional, Kashyap, J, additional, Kothari, Y, additional, TaddeI, S, additional, Scherillo, M, additional, Zacà, V, additional, Genovese, S, additional, Salvioni, A, additional, Fucili, A, additional, Fedele, F, additional, Cosmi, F, additional, Volpe, M, additional, Mazzone, C, additional, Esposito, G, additional, Doi, M, additional, Yamamoto, H, additional, Sakagami, S, additional, Oishi, S, additional, Yasaka, Y, additional, Tsuboi, H, additional, Fujino, Y, additional, Matsuoka, S, additional, Watanabe, Y, additional, Himi, T, additional, Ide, T, additional, Ichikawa, M, additional, Kijima, Y, additional, Koga, T, additional, Yuda, S, additional, Fukui, K, additional, Kubota, T, additional, Manita, M, additional, Fujinaga, H, additional, Matsumura, T, additional, Fukumoto, Y, additional, Kato, R, additional, Kawai, Y, additional, Hiasa, G, additional, Kazatani, Y, additional, Mori, M, additional, Ogimoto, A, additional, Inoko, M, additional, Oguri, M, additional, Kinoshita, M, additional, Okuhara, K, additional, Watanabe, N, additional, Ono, Y, additional, Otomo, K, additional, Sato, Y, additional, Matsunaga, T, additional, Takaishi, A, additional, Miyagi, N, additional, Uehara, H, additional, Takaishi, H, additional, Urata, H, additional, Kataoka, T, additional, Matsubara, H, additional, Matsumoto, T, additional, Suzuki, T, additional, Takahashi, N, additional, Imamaki, M, additional, Yoshitama, T, additional, Saito, T, additional, Sekino, H, additional, Furutani, Y, additional, Koda, M, additional, Shinozaki, T, additional, Hirabayashi, K, additional, Tsunoda, R, additional, Yonezawa, K, additional, Hori, H, additional, Yagi, M, additional, Arikawa, M, additional, Hashizume, T, additional, Ishiki, R, additional, Koizumi, T, additional, Nakayama, K, additional, Taguchi, S, additional, Nanasato, M, additional, Yoshida, Y, additional, Tsujiyama, S, additional, Nakamura, T, additional, Oku, K, additional, Shimizu, M, additional, Suwa, M, additional, Momiyama, Y, additional, Sugiyama, H, additional, Kobayashi, K, additional, Inoue, S, additional, Kadokami, T, additional, Maeno, K, additional, Kawamitsu, K, additional, Maruyama, Y, additional, Nakata, A, additional, Shibata, T, additional, Wada, A, additional, Cho, H-J, additional, Na, JO, additional, Yoo, B-S, additional, Choi, J-O, additional, Hong, SK, additional, Shin, J-H, additional, Cho, M-C, additional, Han, SH, additional, Jeong, J-O, additional, Kim, J-J, additional, Kang, SM, additional, Kim, D-S, additional, Kim, MH, additional, Llamas Esperon, G, additional, Illescas Díaz, J, additional, Fajardo Campos, P, additional, Almeida Alvarado, J, additional, Bazzoni Ruiz, A, additional, Echeverri Rico, J, additional, Lopez Alcocer, I, additional, Valle Molina, L, additional, Hernandez Herrera, C, additional, Calvo Vargas, C, additional, Padilla Padilla, FG, additional, Rodriguez Briones, I, additional, Chuquiure Valenzuela, EJJR, additional, Aguilera Real, ME, additional, Carrillo Calvillo, J, additional, Alpizar Salazar, M, additional, Cervantes Escárcega, JL, additional, Velasco Sanchez, R, additional, Al - Windy, N, additional, van Heerebeek, L, additional, Bellersen, L, additional, Brunner-La Rocca, H-P, additional, Post, J, additional, Linssen, GCM, additional, van de Wetering, M, additional, Peters, R, additional, van Stralen, R, additional, Groutars, R, additional, Smits, P, additional, Yilmaz, A, additional, Kok, WEM, additional, Van der Meer, P, additional, Dijkmans, P, additional, Troquay, R, additional, van Alem, AP, additional, Van de Wal, R, additional, Handoko, L, additional, Westendorp, ICD, additional, van Bergen, PFMM, additional, Rensing, BJWM, additional, Hoogslag, P, additional, Kietselaer, B, additional, Kragten, JA, additional, den Hartog, FR, additional, Alings, A, additional, Danilowicz-Szymanowicz, L, additional, Raczak, G, additional, Piesiewicz, W, additional, Zmuda, W, additional, Kus, W, additional, Podolec, P, additional, Musial, W, additional, Drelich, G, additional, Kania, G, additional, Miekus, P, additional, Mazur, S, additional, Janik, A, additional, Spyra, J, additional, Peruga, J, additional, Balsam, P, additional, Krakowiak, B, additional, Szachniewicz, J, additional, Ginel, M, additional, Grzybowski, J, additional, Chrustowski, W, additional, Wojewoda, P, additional, Kalinka, A, additional, Zurakowski, A, additional, Koc, R, additional, Debinski, M, additional, Fil, W, additional, Kujawiak, M, additional, Forys, J, additional, Kasprzak, M, additional, Krol, M, additional, Michalski, P, additional, Mirek-Bryniarska, E, additional, Radwan, K, additional, Skonieczny, G, additional, Stania, K, additional, Skoczylas, G, additional, Madej, A, additional, Jurowiecki, J, additional, Firek, B, additional, Wozakowska-Kaplon, B, additional, Cymerman, K, additional, Neutel, J, additional, Adams, K, additional, Balfour, P, additional, Deswal, A, additional, Djamson, A, additional, Duncan, P, additional, Hong, M, additional, Murray, C, additional, Rinde-Hoffman, D, additional, Woodhouse, S, additional, MacNevin, R, additional, Rama, B, additional, Broome-Webster, C, additional, Kindsvater, S, additional, Abramov, D, additional, Barettella, M, additional, Pinney, S, additional, Herre, J, additional, Cohen, A, additional, Vora, K, additional, Challappa, K, additional, West, S, additional, Baum, S, additional, Cox, J, additional, Jani, S, additional, Karim, A, additional, Akhtar, A, additional, Quintana, O, additional, Paukman, L, additional, Goldberg, R, additional, Bhatti, Z, additional, Budoff, M, additional, Bush, E, additional, Potler, A, additional, Delgado, R, additional, Ellis, B, additional, Dy, J, additional, Fialkow, J, additional, Sangrigoli, R, additional, Ferdinand, K, additional, East, C, additional, Falkowski, S, additional, Donahoe, S, additional, Ebrahimi, R, additional, Kline, G, additional, Harris, B, additional, Khouzam, R, additional, Jaffrani, N, additional, Jarmukli, N, additional, Kazemi, N, additional, Koren, M, additional, Friedman, K, additional, Herzog, W, additional, Silva Enciso, J, additional, Cheung, D, additional, Grover-McKay, M, additional, Hauptman, P, additional, Mikhalkova, D, additional, Hegde, V, additional, Hodsden, J, additional, Khouri, S, additional, McGrew, F, additional, Littlefield, R, additional, Bradley, P, additional, McLaurin, B, additional, Lupovitch, S, additional, Labin, I, additional, Rao, V, additional, Leithe, M, additional, Lesko, M, additional, Lewis, N, additional, Lombardo, D, additional, Mahal, S, additional, Malhotra, V, additional, Dauber, I, additional, Banerjee, A, additional, Needell, J, additional, Miller, G, additional, Paladino, L, additional, Munuswamy, K, additional, Nanna, M, additional, McMillan, E, additional, Mumma, M, additional, Napoli, M, additional, Nelson, W, additional, O'Brien, T, additional, Adlakha, A, additional, Onwuanyi, A, additional, Serota, H, additional, Schmedtje, J, additional, Paraschos, A, additional, Potu, R, additional, Sai-Sudhakar, C, additional, Saltzberg, M, additional, Sauer, A, additional, Shah, P, additional, Skopicki, H, additional, Bui, H, additional, Carr, K, additional, Stevens, G, additional, Tahirkheli, N, additional, Tallaj, J, additional, Yousuf, K, additional, Trichon, B, additional, Welker, J, additional, Tolerico, P, additional, Vest, A, additional, Vivo, R, additional, Wang, X, additional, Abadier, R, additional, Dunlap, S, additional, Weintraub, N, additional, Malik, A, additional, Kotha, P, additional, Zaha, V, additional, Kim, G, additional, Uriel, N, additional, Greene, T, additional, Salacata, A, additional, Arora, R, additional, Gazmuri, R, additional, Kobayashi, J, additional, Iteld, B, additional, Vijayakrishnan, R, additional, Dab, R, additional, Mirza, Z, additional, Marques, V, additional, Nallasivan, M, additional, Bensimhon, D, additional, Peart, B, additional, Saint-Jacques, H, additional, Barringhaus, K, additional, Contreras, J, additional, Gupta, A, additional, Koneru, S, additional, and Nguyen, V, additional

Published
2022
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28. Trend Review of Solar Energy Forecasting Technique

Author

Yong-Heack Kang, Hyun-Goo Kim, Chang-Yeol Yun, Boyoung Kim, Jae ho Cheon, Jung Tae Lee, Jin Young Kim, Tae Hyun Kim, Yu Yeon Park, Ha Na Jo, and Chang Ki Kim

Subjects
Meteorology, business.industry, Environmental science, Solar energy, business
Published
2019

29. Unusual Thermal Conductivity of Carbon Nanosheets with Self-Emerged Graphitic Carbon Dots

Author

Gun Young Jung, Su-Young Son, Sungho Lee, Han-Ik Joh, Min Park, Hae-Na Jo, and Dong Su Lee

Subjects
chemistry.chemical_classification, Materials science, Graphene, Carbonization, Oxide, chemistry.chemical_element, 02 engineering and technology, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, law.invention, chemistry.chemical_compound, symbols.namesake, Thermal conductivity, chemistry, Chemical engineering, law, symbols, Molecule, General Materials Science, 0210 nano-technology, Raman spectroscopy, Carbon
Abstract

The thermal conductivity (κ) of two-dimensional conducting and transparent carbon nanosheets (CNSs) prepared by a catalyst- and transfer-free process is calculated for the first time by the optothermal Raman technique. A systematic structural analysis of CNSs reveals that the thickness of polymer films affects the interaction between molecules and a Si wafer significantly, thus helping to determine the ratio of sp2 and sp3 bonding configurations of carbon (C) atoms in the CNS. Notably, the holding time of carbonization can realize a hierarchical structure with graphitic carbon dots emerging from the CNS through the rearrangement of carbon atoms, leading to the excellent κ value of 540 W/(m·K) at 310 K. It is demonstrated that an appropriate increase in carbonization time can be an effective approach for improving the ratio of sp2- to sp3-bonded C atoms in the CNS. The thermal conductivity of the CNS with the highest ratio of sp2- to sp3-bonded C atoms exhibits superior behavior and is comparable to that of reduced graphene oxide and supported graphene, respectively. Finally, when the CNS with the highest κ value of 540 W/(m·K) was applied to a heater as the heat-dissipating material, the heater showed the temperature decrease by 14 °C compared to the case without the CNS. The catalyst- and transfer-free approach for the synthesis of CNSs is highly desirable for use as heat sink materials or substrates with heat dissipation functions for extensively integrated electronic devices.

Published
2019

31. Development of an Electrooculogram (EOG) and Surface Electromyogram (sEMG)-Based Human Computer Interface (HCI) Using a Bone Conduction Headphone Integrated Bio-Signal Acquisition System

Author

Ha Na Jo, Sung Woo Park, Han Gyeol Choi, Seok Hyun Han, and Tae Seon Kim

Subjects
Computer Networks and Communications, Hardware and Architecture, Control and Systems Engineering, Signal Processing, Electrical and Electronic Engineering, human–computer interface (HCI), electrooculogram (EOG), surface electromyogram (sEMG), horizontal gaze angle, virtual keyboard
Abstract

Human–computer interface (HCI) methods based on the electrooculogram (EOG) signals generated from eye movement have been continuously studied because they can transmit the commands to a computer or machine without using both arms. However, usability and appearance are the big obstacles to practical applications since conventional EOG-based HCI methods require skin electrodes outside the eye near the lateral and medial canthus. To solve these problems, in this paper, we report development of an HCI method that can simultaneously acquire EOG and surface-electromyogram (sEMG) signals through electrodes integrated into bone conduction headphones and transmit the commands through the horizontal eye movements and various biting movements. The developed system can classify the position of the eyes by dividing the 80-degree range (from −40 degrees to the left to +40 degrees to the right) into 20-degree sections and can also recognize the three biting movements based on the bio-signals obtained from the three electrodes, so a total of 11 commands can be delivered to a computer or machine. The experimental results showed the interface has accuracy of 92.04% and 96.10% for EOG signal-based commands and sEMG signal-based commands, respectively. As for the results of virtual keyboard interface application, the accuracy was 97.19%, the precision was 90.51%, and the typing speed was 5.75–18.97 letters/min. The proposed interface system can be applied to various HCI and HMI fields as well as virtual keyboard applications.

Published
2022

32. An Interactive Fire Animation on a Mobile Environment

Author

SangHyuk Woo, DoHoon Lee, Mi-Ri-Na Jo, and DongGyu Park

Subjects
Multimedia, business.industry, Computer science, Mobile computing, Application software, computer.software_genre, Computer graphics, Mobile phone, Mobile technology, Mobile telephony, business, Physically based animation, computer, Computer animation, ComputingMethodologies_COMPUTERGRAPHICS
Abstract

In computer graphics, fluid-like motion is an important and challenging problem with many applications. Currently, the graphical performance and resolution of the mobile phone is highly improved; therefore, mobile 3D games are more and more popular items in the field of mobile services. Yet interactive physically-based fluid simulation is still challenging for mobile platforms. Stable and fast fluid simulation methods are well developed in PC and console games, but fluid simulation and interactive fluid models still have many problems in the mobile environment. We studied and implemented physically- based models for fluids like fire and smoke effects on a Mobile 3D environment.

Published
2021

40. Work function control in carbon nanosheets via chloride-based metal precursors and their applications as transparent electrodes

Author

Myong-Hoon Lee, Jun-Seok Yeo, Seok-In Na, Han-Ik Joh, Sungho Lee, Su-Young Son, Hae-Na Jo, and Sae-Mi Park

Subjects
Spin coating, Materials science, General Chemical Engineering, Metal ions in aqueous solution, Energy conversion efficiency, Inorganic chemistry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Chloride, 0104 chemical sciences, Electron transfer, chemistry, Electrode, medicine, Work function, 0210 nano-technology, Carbon, medicine.drug
Abstract

Work function of carbon nanosheets (CNSs) is easily controlled using various chloride-based metal precursors. The metal ions in the precursors are reduced despite the simple spin coating without post-treatment due to electron transfer from the CNSs to the ions. The work function of CNSs doped with AuCl3, ZnCl2, and CoCl2 presented values of 4.91, 4.77, and 4.69 eV, respectively, which are significantly higher than pristine CNSs (4.60 eV). The reduced metal nanoparticles locally induced electronic modification of the CNSs located in the vicinity, leading to transparent conducting electrodes with high work functions and subsequently a high power conversion efficiency of ∼2.01% for an ITO-free OPV incorporating a AuCl3-doped CNS electrode.

Published
2017

41. The Impact of CEO's Values System and Employee's Awareness, Sympathy on Organizational Performance

Author

Mi-Na Jo and Dong-Hyun Lee

Subjects
030506 rehabilitation, Financial performance, Employee research, business.industry, media_common.quotation_subject, 05 social sciences, Public relations, Organizational performance, 03 medical and health sciences, Political science, 0502 economics and business, Sympathy, Corporate social responsibility, 0305 other medical science, business, Social psychology, 050203 business & management, media_common
Published
2016

44. The Effect of the Corporate Social Responsibility of Franchise Coffee Shops on Corporate Image and Behavioral Intention

Author

Mi-Na Jo and Jae-Bin Cha

Subjects
Renewable Energy, Sustainability and the Environment, 05 social sciences, Geography, Planning and Development, Management, Monitoring, Policy and Law, Antecedent (grammar), corporate image, Sustainable management, behavioral intention, 0502 economics and business, Accountability, Corporate social responsibility, 050211 marketing, Business, Franchise, Product (category theory), Marketing, CSR, Social responsibility, 050203 business & management, Consumer behaviour
Abstract

This study investigated the effects of the corporate social responsibility (CSR) of franchise coffee shops on their corporate image and their customers&rsquo, behavioral intention. From 5 October 2017 to 26 October 2017, a total of 300 survey questionnaires were distributed, out of which 285 were analyzed. Accordingly, among the dimensions of CSR, only the economic, discretionary, and legal responsibilities had significant effects on corporate image. Moreover, corporate image had a significant effect on customers&rsquo, behavioral intention. Therefore, the CSR of franchise coffee shops is an important antecedent of corporate image, while corporate image is an important antecedent of behavioral intention. With respect to the pyramid of CSR, economic responsibilities should be first fulfilled prior to other social responsibilities. In addition, CSR programs will become the core task of corporate sustainable management because CSR can potentially influence consumers to have a positive behavioral intention and can result in product preferences by conveying a particular corporate image.

Published
2019

45. Changes in physical properties of Yukwa (fried rice snack) by soybean extract concentration and incubation time

Author

Mi Na Jo and Seong-Jun Cho

Subjects
0301 basic medicine, 030109 nutrition & dietetics, Expansion rate, Chemistry, fungi, food and beverages, Oil absorption, Applied Microbiology and Biotechnology, Article, Incubation period, 03 medical and health sciences, Response surface methodology, Food science, Food Science, Biotechnology
Abstract

This study assessed the effects of soybean extract concentration and incubation time on the physical properties of Yukwa, a traditional Korean oil-puffed snack. Notably, whiteness decreased, while redness and yellowness increased as the soybean extract concentration increased. The expansion rate of Yukwa increased as the soybean extract concentration increased. Moreover, that in the 0 and 7% soybean extract groups decreased, followed by slight increase as the incubation time increased, and the 14% soybean extract treatment group showed increased expansion with incubation time. The oil absorption rate of Yukwa increased with soybean extract concentration and incubation time, and the hardness of Yukwa was decreased as the soybean extract concentration and incubation time increased. Peak number increased with soybean extract concentration, but decreased with incubation time. Finally, response surface analysis showed that a soybean extract concentration of 7.69% and incubation time of 6.41 h were optimal for achieving the desired peak number.

Published
2018

48. Effect of anthocyanins from rabbit-eye blueberry (Vaccinium virgatum) on cognitive function in mice under trimethyltin-induced neurotoxicity

Author

Dae-Ok Kim, Yu Na Jo, Ji Hee Jeong, Hyeon Ju Kim, Ho Jin Heo, and Dong Eun Jin

Subjects
ABTS, biology, Vaccinium virgatum, Neurotoxicity, food and beverages, biology.organism_classification, medicine.disease, Applied Microbiology and Biotechnology, Lipid peroxidation, chemistry.chemical_compound, Biochemistry, chemistry, In vivo, Anthocyanin, medicine, Viability assay, Delphinidin, Food Science, Biotechnology
Abstract

Extracts of rabbit-eye blueberries (Vaccinium virgatum) were investigated for in vitro neuroprotective and in vivo learning and memory effects in mice under trimethyltin (TMT)-induced neurotoxicity. Blueberry anthocyanins showed high in vitro antioxidant activities in ABTS and 2’,7’-dichlorofluorescein diacetate (DCF-DA) assays. In a cell viability assay using MTT, anthocyanins showed protective effects, and lactate dehydrogenase release into the medium was effectively inhibited. Drug-induced cognitive deficits, examined in vivo using Y-maze and passive avoidance testing, were ameliorated by the anthocyanin fraction. HPLC analysis showed that delphinidin was the predominant anthocyanin. After behavioral testing, acetylcholinesterase (AChE) activities and lipid peroxidation in the mouse brain were investigated for biochemical changes. Administration of blueberry anthocyanins reduced the level of TMT-induced memory injury via inhibition of the AChE activity and lipid peroxidation.

Published
2015

49. Edoxaban versus warfarin in patients with atrial fibrillation

Author

Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. Jr, Reissner C, Smith K, Ostroske J, Ron A, Giugliano R, Connolly S, Camm J, Ezekowitz M, Halperin J, Waldo A, Paolasso E, Aylward P, Heidbuchel H, Nicolau JC, Goudev A, Roy D, Weitz J, Corbalán R, Yang Y, Botero R, Bergovec M, Ŝpinar J, Grande P, Hassager C, Voitk J, Huikuri H, Nieminen M, Blanc JJ, LeHeuzey JY, Mitrovic V, Alexopoulos D, Sotomora G, Kiss R, SomaRaju B, Lewis B, Merlini P, Metra M, Koretsune Y, Yamashita T, García Castillo A, Ophuis T, White H, Atar D, Horna M, Babilonia N, Ruzyllo W, Morais J, Dorobantu M, Ruda M, Ostojic M, Duris T, Dalby A, Chung N, Zamorano JL, Juul Möller S, Moccetti T, Chen SA, Sritara P, Oto A, Parkhomenko A, Senior R, Verheugt F, Skene A, Anderson J, Bauer K, Easton JD, Goto S, Wiviott S, Lowe C, Awtry E, Berger CJ, Croce K, Desai A, Gelfand E, Goessling W, Greenberger NJ, Ho C, Leeman DE, Link MS, Norden AD, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita JA, Vogelmann O, Gonzalez C, Ahuad Guerrero R, Rodriguez M, Albisu J, Rosales E, Allall O, Reguero M, Alvarez C, Garcia M, Ameriso S, Ameriso P, Amuchastegui M, Caceres M, Beloscar J, Petrucci J, Berli M, Budassi N, Valle M, Bustamante Labarta G, Saravia M, Caccavo A, Fracaro V, Cartasegna L, Novas V, Caruso O, Zarandon RS, Colombo H, Morandini M, Cuello J, Rosell M, Cuneo C, Bocanera M, D'Amico A, Cendali G, Dran R, Moreno V, Estol C, Davolos M, Facello A, Facello M, Falu E, Iriarte M, Femenia F, Arrieta M, Fuselli J, Zanotti A, Gant Lopez J, Meiller F, Garcia Duran R, Perlo D, Garrido M, Ceirano C, Giacomi G, Eden M, Giannaula R, Huerta M, Goicoechea R, von Wulffen M, Hominal M, Bianchini M, Jure H, Jure D, Kevorkian R, Monaco F, Lanternier G, Belcuore M, Liniado G, Iglesias M, Litvak B, Nigro A, Llanos J, Vignau S, Lorente C, Shatsky K, Lotti J, Raimondi G, Mackinnon I, Carne M, Manuale O, Calderon M, Marino J, Funes I, Muntaner J, Gandur H, Nul D, Verdini E, Piskorz D, Tommasi A, Povedano G, Casares E, Pozzer D, Fernandez E, Prado A, Venturini C, Ramos H, Navarrete S, Alvarez M, Sanchez A, Bowen L, Sanjurjo M, Codutti O, Saravia Toledo S, Formoso I, Schmidberg J, Goloboulicz A, Schygiel P, Buzzetti C, Severino P, Morara P, Sosa Liprandi M, Teves M, Vico M, Morell Y, Anderson C, Paraskevaidis T, Arstall M, Hoffmann B, Colquhoun D, Price Smith S, Crimmins D, Slattery A, Dart A, Kay S, Davis S, Silver G, Flecknoe Brown S, Roberts J, Gates P, Jones S, Lehman R, Morrison H, McKeirnan M, Li J, Paul V, Batta C, Purnell P, Perrett L, Szto G, O'Shea V, Capiau L, Banaeian F, De Bleecker J, de Koning K, De Tollenaere M, De Bruyne L, Desfontaines P, Tincani G, Meeusen K, Herzet J, Malmendier D, Mairesse G, Raepers M, Parqué J, Clinckemaille N, Scavée C, Huyberechts D, Stockman D, Jacobs C, Vandekerckhove Y, Derycker K, Vanwelden J, van Welden J, Vervoort G, Mestdagh I, Vrolix M, Beerts C, Wollaert B, Denie D, Amato Vincenzo de Paola A, Coutinho E, Andrade Lotufo P, de Melo RF, Atie J, Motta C, Augusto Alves da Costa F, Ferraz RF, Bertolim Precoma D, Sehnem E, Botelho R, Cunha S, Brondani R, Fleck N, Chaves Junior H, Silva J, Costantini C, Barroso D, De Patta M, Pereira V, Duda N, Laimer R, Dutra O, Morgado S, Faustino Saporito W, Seroqui M, Ferreira L, Araújo E, Finimundi H, Daitz C, Gagliardi R, Pereira G, Gomes M, Gomes A, Guimarães A, Ninho L, Jaeger C, Pereira L, Jorge J, Cury C, Kaiser S, Almeida A, Kalil C, Radaelli G, Kunz Sebba Barroso de Souza W, Morales K, Leaes P, Luiz RO, Pimenta Almeida J, Gozalo A, Reis G, Avellar K, Reis Katz Weiand L, Leipelt J, Rocha J, Barros R, Rodrigues L, Rocha MR, Rodrigues A, Rodrigues D, Rossi dos Santos F, Pagnan LG, Sampaio R, do Val R, Saraiva J, Vicente C, Simoes M, Carraro A, Sobral Filho D, Lustosa E, Villas Boas F, Almeida M, Zimmermann S, Zimmermann EB, Chompalova B, Parishev G, Denchev S, Milcheva N, Donova T, Gergova V, Georgiev B, Kostova E, Kinova E, Hergeldjieva V, Kamenova P, Manolova A, Vasilev I, Mihov A, Miteva B, Mincheva V, Stoyanovski V, Nikolov F, Vasilev D, Pencheva G, Kostov K, Petranov S, Milusheva T, Popov A, Staneva A, Momchilova Lozeva D, Todorov G, Nyagina M, Tumbev H, Tumbeva D, Tzekova M, Kitova M, Manoylov E, Archibald J, Antle S, Bhargava R, Stafford C, Bose S, Hundseth M, Cha J, Otis J, Chehayeb R, Lepage C, Chilvers M, Vansickle L, Cleveland D, Valley S, Constance C, Gauthier M, Costi P, Masson C, Coutu B, Denis I, du Preez M, Kubanska A, Dufresne M, Krider J, Eikelboom J, Zondag M, Fortin C, Viau C, Green M, Houbraken D, Hatheway R, Mabee J, Heath J, Scott L, Ho K, Ho V, Hoag G, Standring R, Huynh T, Perkins L, Kouz S, Roy M, Labonte R, Dewar C, Lainesse A, St Germain L, Lam S, Lam H, Lichtenstein T, Roberts P, Luton R, Douglas S, Ma P, Seib M, MacCallum C, Matthews J, Malette P, Vaillancourt T, Maranda C, Studenikow E, Mawji A, Morely A, Morrison D, Roth M, Mucha M, Najarali A, Lamoureux U, Nicholson R, O'Hara G, Banville P, O'Mahony W, Bolton R, Parkash R, Carroll L, Pesant Y, Sardin V, Polasek P, Turri L, Qureshi A, Nethercott C, Ricci J, Bozek B, Rupka D, Marchand C, Shu D, Silverio G, St Hilaire R, Morissette A, Sussman J, Kailey P, Syan G, Bobbie C, Talajic M, David D, Talbot P, Tremblay M, Teitelbaum I, Teitelbaum J, Velthuysen G, Giesbrecht L, Wahby R, Morley A, Wharton S, Caterini T, Woodford T, Balboa W, Matus LR, Bugueño C, Mondaca PM, Cobos J, Obreque C, Corbalan R, Parada A, Florenzano F, Diaz PA, Lopetegui M, Rebolledo C, Manriquez L, Silva LM, Martinez D, Llamas RR, Opazo M, Pérez MC, Pincetti C, Carrasco GT, Potthoff S, Staub JZ, Campisto Y, Stockins B, Lara CL, Yovaniniz P, Azua MG, Bai F, Xu GL, Chen JZ, Xie XD, Chen XP, Zhang X, Dong YG, Feng C, Fu GS, Zhang P, Hong K, You ZG, Hong L, Qiu Y, Jiang XJ, Qu Z, Li L, Liu H, Li TF, Kong YQ, Li WM, Liu B, Li ZQ, Liu Y, Liao DN, Gu XJ, Liu L, Lu ZH, Ma SM, Yang ZY, Wang DM, Qi SY, Wang GP, Shi XJ, Wei M, Huang D, Wu SL, Li YE, Xu JH, Gu JY, Xu YM, Liang YZ, Yang K, Li AY, Yang YJ, Zheng X, Zheng Y, Gao M, Yin YH, Xu YP, Yu B, Li LL, Yuan ZY, Qiang H, Zhang HQ, Lin YN, Zhang Z, Kang H, Zhao RP, Han RJ, Zhao XL, Wang JQ, Zheng ZQ, Li BG, Zhou SX, Zhang YL, Accini J, Accini M, Cano N, Pineda LL, Delgado Restrepo J, Arroyave C, Fernández Ruiz R, Diaz IA, Hernandez H, Delgado P, Jaramillo Muñoz C, Builes A, Manzur F, Rodriguez ER, Moncada Corredor M, Giraldo DL, Orozco Linares L, Fonseca J, Quintero A, Gonzales C, Sanchez Vallejo G, Mejia IP, Bagatin J, Carevic V, Car S, Jeric M, Ciglenecki N, Tusek S, Ferri Certic J, Romic I, Francetic I, Ausperger KM, Jelic V, Jurinjak SJ, Knezevic A, Buksa B, Samardzic P, Lukenda KC, Steiner R, Kirner D, Sutalo K, Bakliza Z, Vrazic H, Lucijanic T, Bar M, Brodova P, Berka L, Kunkelova V, Brtko M, Burianova H, Cermak O, Elbl L, Ferkl R, Florian J, Francek L, Golan L, Gregor P, Honkova M, Hubac J, Jandik J, Jarkovsky P, Jelinek Z, Jerabek O, Jirmar R, Kobza R, Kochrt M, Kostkova G, Kosek Z, Kovar P, Kuchar R, Kvasnicka J, Ludka O, Machova V, Krocova E, Melichar M, Nechanicky R, Olsr J, Peterka K, Petrova I, Havlova I, Pisova J, Podrazil P, Jirsova E, Reichert P, Slaby J, Spacek R, Spinar J, Labrova R, Vodnansky P, Samkova D, Zidkova E, Dodt K, Christensen H, Christensen L, Loof A, Ibsen H, Madsen H, Iversen H, Veng Olsen T, Nielsen H, Olsen R, Overgaard K, Petrovic V, Raymond I, Raae D, Sand N, Svenningsen A, Torp Pedersen C, Jakobsen U, Wiggers H, Serup Hansen K, Kaik J, Stern A, Kolk R, Laane E, Rivis L, Paumets M, Laheäär M, Rosenthal A, Rajasalu R, Vahula V, Ratnik E, Kaarleenkaski S, Hussi E, Valpas S, Jäkälä P, Lappalainen T, Mäenpää A, Viitaniemi J, Nyman K, Sankari T, Rasi H, Salminen O, Virtanen V, Nappila H, Le Heuzey J, Agraou B, El Jarroudi F, Amarenco P, Boursin P, Babuty D, Boyer M, Belhassane A, Berbari H, Blanc J, Dias P, Coisne D, Berger N, Decoulx E, El Jarroudi M, Dinanian S, Arfaoui M, Hermida J, Deruche E, Kacet S, Corbut S, Poulard J, Leparree S, Roudaut R, Duprat C, Al Zoebi A, Wurow A, Bernhardt P, Dichristin U, Berrouschot J, Vierbeck S, Beyer Westendorf J, Sehr B, Bouzo M, Schnelzer P, Braun R, Ladenburger K, Buhr M, Weihrauch D, Contzen C, Kara M, Daut W, Ayasse D, Degtyareva E, Kranz P, Drescher T, Herfurth B, Faghih M, Forck Boedeker K, Schneider K, Fuchs R, Manuela W, Grigat C, Otto A, Hartmann A, Peitz M, Heuer H, Dieckheuer U, Hoffmann U, Dorn S, Hoffmann S, Schuppe M, Horacek T, Fink P, Junggeburth J, Schmid S, Jungmair W, Schoen B, Kleinecke Pohl U, Meusel P, Koenig H, Bauch F, Lohrbaecher Kozak I, Grosse B, Lueders S, Venneklaas U, Luttermann M, Wulf M, Maus O, Hoefer K, Meissner G, Braemer U, Meyer Pannwitt U, Frahm E, Vogt S, Muegge A, Barbera S, Mueller Glamann M, Raddatz K, Piechatzek R, Lewinsky D, Pohl W, Proskynitopoulos N, Kuhlmann M, Rack K, Pilipenko H, Rinke A, Kühlenborg A, Schaefer A, Szymanowski N, Schellong S, Frommhold R, Schenkenberger I, Finsterbusch T, Dreykluft K, Schiewe C, Schmidt A, Schmidt M, Schreckenberg A, Hellmers J, Seibert H, Gold G, Sohn H, Baylacher M, Spitzer S, Bonin K, Stoehring R, Taggeselle J, Zarpentin C, Veltkamp R, Ludwig I, Voehringer, Buchholz M, Weyland K, Winkelmann B, Buelow Johansen B, Wolde C, Winter K, Mavronasiou E, Bourlios P, Tziortziotis A, Karamitsos C, Exarchou E, Kifnidis K, Daskalaki A, Moschos N, Dimitra K, Olympios C, Kartsagkoulis E, Pyrgakis V, Korantanis K, Ayau Milla O, Ramirez Vde L, Guzman Melgar I, Jimenez T, Ovando Lavagnino A, Guevara S, Rodas Estrada M, Sanchez M, Pozuelos JM, Sanchez Samayoa C, Guerra L, Velasquez Camas L, Almaraz SP, Dioszeghy P, Muskoczki E, Edes I, Szatmari J, Fiok J, Varga A, Kanakaridisz N, Kosztyu M, Kis E, Feil JF, Jakal A, Koczka M, Kovacs I, Baranyai M, Kovacs Z, Lupkovics G, Karakai HH, Matoltsy A, Kiss T, Medvegy M, Kiss K, Merkely B, Kolumban E, Nagy A, Palinkas A, Toth SR, Sayour A, Bognar A, Simor T, Ruzsa D, Sipos T, Szakal I, Tomcsanyi J, Marosi A, Vertes A, Kincses M, Malhan S, Abdullakutty J, Agarwal D, Ranka R, Arneja J, Memon A, Arora V, Shree R, Avvaru G, Shaikh A, Babu P, Rao B, Babu R, 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H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., Murphy, Stephen D., Wiviott, Jonathan L., Halperin, Albert L., Waldo, Michael D., Ezekowitz, Jeffrey I., Weitz, Jind?ich, ?pinar, Witold, Ruzyllo, Mikhail, Ruda, Yukihiro, Koretsune, Joshua, Betcher, Minggao, Shi, Laura T., Grip, Shirali P., Patel, Indravadan, Patel, James J., Hanyok, Michele, Mercuri, Elliott M., Antman, Morin, Se, Hoffman, Eb, Deenadayalu, N, Grip, L, Lanz, H, Curt, V, Duggal, A, Hanyok, J, Davé, J, Morgan, D, Choi, Y, Jin, J, Xie, J, Crerand, W, Kappelhof, J, Maxwell, W, Skinner, M, Patel, S, Selicato, G, Otto C., Jr, Reissner, C, Smith, K, Ostroske, J, Ron, A, Giugliano, R, Connolly, S, Camm, J, Ezekowitz, M, Halperin, J, Waldo, A, Paolasso, E, Aylward, P, Heidbuchel, H, Nicolau, Jc, Goudev, A, Roy, D, Weitz, J, Corbalán, R, Yang, Y, Botero, R, Bergovec, M, Ŝpinar, J, Grande, P, Hassager, C, Voitk, J, Huikuri, H, Nieminen, M, Blanc, Jj, Leheuzey, Jy, Mitrovic, V, Alexopoulos, D, Sotomora, G, Kiss, R, Somaraju, B, Lewis, B, Merlini, P, Metra, M, Yamashita, T, García Castillo, A, Ophuis, T, White, H, Atar, D, Horna, M, Babilonia, N, Morais, J, Dorobantu, M, Ostojic, M, Duris, T, Dalby, A, Chung, N, Zamorano, Jl, Juul Möller, S, Moccetti, T, Chen, Sa, Sritara, P, Oto, A, Parkhomenko, A, Senior, R, Verheugt, F, Skene, A, Anderson, J, Bauer, K, Easton, Jd, Goto, S, Wiviott, S, Lowe, C, Awtry, E, Berger, Cj, Croce, K, Desai, A, Gelfand, E, Goessling, W, Greenberger, Nj, Ho, C, Leeman, De, Link, M, Norden, Ad, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, Ja, Vogelmann, O, Gonzalez, C, Ahuad Guerrero, R, Rodriguez, M, Albisu, J, Rosales, E, Allall, O, Reguero, M, Alvarez, C, Garcia, M, Ameriso, S, Ameriso, P, Amuchastegui, M, Caceres, M, Beloscar, J, Petrucci, J, Berli, M, Budassi, N, Valle, M, Bustamante Labarta, G, Saravia, M, Caccavo, A, Fracaro, V, Cartasegna, L, Novas, V, Caruso, O, Zarandon, R, Colombo, H, Morandini, M, Cuello, J, Rosell, M, Cuneo, C, Bocanera, M, D'Amico, A, Cendali, G, Dran, R, Moreno, V, Estol, C, Davolos, M, Facello, A, Facello, M, Falu, E, Iriarte, M, Femenia, F, Arrieta, M, Fuselli, J, Zanotti, A, Gant Lopez, J, Meiller, F, Garcia Duran, R, Perlo, D, Garrido, M, Ceirano, C, Giacomi, G, Eden, M, Giannaula, R, Huerta, M, Goicoechea, R, von Wulffen, M, Hominal, M, Bianchini, M, Jure, H, Jure, D, Kevorkian, R, Monaco, F, Lanternier, G, Belcuore, M, Liniado, G, Iglesias, M, Litvak, B, Nigro, A, Llanos, J, Vignau, S, Lorente, C, Shatsky, K, Lotti, J, Raimondi, G, Mackinnon, I, Carne, M, Manuale, O, Calderon, M, Marino, J, Funes, I, Muntaner, J, Gandur, H, Nul, D, Verdini, E, Piskorz, D, Tommasi, A, Povedano, G, Casares, E, Pozzer, D, Fernandez, E, Prado, A, Venturini, C, Ramos, H, Navarrete, S, Alvarez, M, Sanchez, A, Bowen, L, Sanjurjo, M, Codutti, O, Saravia Toledo, S, Formoso, I, Schmidberg, J, Goloboulicz, A, Schygiel, P, Buzzetti, C, Severino, P, Morara, P, Sosa Liprandi, M, Teves, M, Vico, M, Morell, Y, Anderson, C, Paraskevaidis, T, Arstall, M, Hoffmann, B, Colquhoun, D, Price Smith, S, Crimmins, D, Slattery, A, Dart, A, Kay, S, Davis, S, Silver, G, Flecknoe Brown, S, Roberts, J, Gates, P, Jones, S, Lehman, R, Morrison, H, Mckeirnan, M, Li, J, Paul, V, Batta, C, Purnell, P, Perrett, L, Szto, G, O'Shea, V, Capiau, L, Banaeian, F, De Bleecker, J, de Koning, K, De Tollenaere, M, De Bruyne, L, Desfontaines, P, Tincani, G, Meeusen, K, Herzet, J, Malmendier, D, Mairesse, G, Raepers, M, Parqué, J, Clinckemaille, N, Scavée, C, Huyberechts, D, Stockman, D, Jacobs, C, Vandekerckhove, Y, Derycker, K, Vanwelden, J, van Welden, J, Vervoort, G, Mestdagh, I, Vrolix, M, Beerts, C, Wollaert, B, Denie, D, Amato Vincenzo de Paola, A, Coutinho, E, Andrade Lotufo, P, de Melo, Rf, Atie, J, Motta, C, Augusto Alves da Costa, F, Ferraz, Rf, Bertolim Precoma, D, Sehnem, E, Botelho, R, Cunha, S, Brondani, R, Fleck, N, Chaves Junior, H, Silva, J, Costantini, C, Barroso, D, De Patta, M, Pereira, V, Duda, N, Laimer, R, Dutra, O, Morgado, S, Faustino Saporito, W, Seroqui, M, Ferreira, L, Araújo, E, Finimundi, H, Daitz, C, Gagliardi, R, Pereira, G, Gomes, M, Gomes, A, Guimarães, A, Ninho, L, Jaeger, C, Pereira, L, Jorge, J, Cury, C, Kaiser, S, Almeida, A, Kalil, C, Radaelli, G, Kunz Sebba Barroso de Souza, W, Morales, K, Leaes, P, Luiz, Ro, Pimenta Almeida, J, Gozalo, A, Reis, G, Avellar, K, Reis Katz Weiand, L, Leipelt, J, Rocha, J, Barros, R, Rodrigues, L, Rocha, Mr, Rodrigues, A, Rodrigues, D, Rossi dos Santos, F, Pagnan, Lg, Sampaio, R, do Val, R, Saraiva, J, Vicente, C, Simoes, M, Carraro, A, Sobral Filho, D, Lustosa, E, Villas Boas, F, Almeida, M, Zimmermann, S, Zimmermann, Eb, Chompalova, B, Parishev, G, Denchev, S, Milcheva, N, Donova, T, Gergova, V, Georgiev, B, Kostova, E, Kinova, E, Hergeldjieva, V, Kamenova, P, Manolova, A, Vasilev, I, Mihov, A, Miteva, B, Mincheva, V, Stoyanovski, V, Nikolov, F, Vasilev, D, Pencheva, G, Kostov, K, Petranov, S, Milusheva, T, Popov, A, Staneva, A, Momchilova Lozeva, D, Todorov, G, Nyagina, M, Tumbev, H, Tumbeva, D, Tzekova, M, Kitova, 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G, St Hilaire, R, Morissette, A, Sussman, J, Kailey, P, Syan, G, Bobbie, C, Talajic, M, David, D, Talbot, P, Tremblay, M, Teitelbaum, I, Teitelbaum, J, Velthuysen, G, Giesbrecht, L, Wahby, R, Morley, A, Wharton, S, Caterini, T, Woodford, T, Balboa, W, Matus, Lr, Bugueño, C, Mondaca, Pm, Cobos, J, Obreque, C, Corbalan, R, Parada, A, Florenzano, F, Diaz, Pa, Lopetegui, M, Rebolledo, C, Manriquez, L, Silva, Lm, Martinez, D, Llamas, Rr, Opazo, M, Pérez, Mc, Pincetti, C, Carrasco, Gt, Potthoff, S, Staub, Jz, Campisto, Y, Stockins, B, Lara, Cl, Yovaniniz, P, Azua, Mg, Bai, F, Xu, Gl, Chen, Jz, Xie, Xd, Chen, Xp, Zhang, X, Dong, Yg, Feng, C, Fu, G, Zhang, P, Hong, K, You, Zg, Hong, L, Qiu, Y, Jiang, Xj, Qu, Z, Li, L, Liu, H, Li, Tf, Kong, Yq, Li, Wm, Liu, B, Li, Zq, Liu, Y, Liao, Dn, Gu, Xj, Liu, L, Lu, Zh, Ma, Sm, Yang, Zy, Wang, Dm, Qi, Sy, Wang, Gp, Shi, Xj, Wei, M, Huang, D, Wu, Sl, Li, Ye, Xu, Jh, Gu, Jy, Xu, Ym, Liang, Yz, Yang, K, Li, Ay, Yang, Yj, Zheng, X, Zheng, Y, Gao, M, Yin, Yh, Xu, Yp, Yu, B, Li, Ll, Yuan, Zy, Qiang, H, Zhang, Hq, Lin, Yn, Zhang, Z, Kang, H, Zhao, Rp, Han, Rj, Zhao, Xl, Wang, Jq, Zheng, Zq, Li, Bg, Zhou, Sx, Zhang, Yl, Accini, J, Accini, M, Cano, N, Pineda, Ll, Delgado Restrepo, J, Arroyave, C, Fernández Ruiz, R, Diaz, Ia, Hernandez, H, Delgado, P, Jaramillo Muñoz, C, Builes, A, Manzur, F, Rodriguez, Er, Moncada Corredor, M, Giraldo, Dl, Orozco Linares, L, Fonseca, J, Quintero, A, Gonzales, C, Sanchez Vallejo, G, Mejia, Ip, Bagatin, J, Carevic, V, Car, S, Jeric, M, Ciglenecki, N, Tusek, S, Ferri Certic, J, Romic, I, Francetic, I, Ausperger, Km, Jelic, V, Jurinjak, Sj, Knezevic, A, Buksa, B, Samardzic, P, Lukenda, Kc, Steiner, R, Kirner, D, Sutalo, K, Bakliza, Z, Vrazic, H, Lucijanic, T, Bar, M, Brodova, P, Berka, L, Kunkelova, V, Brtko, M, Burianova, H, Cermak, O, Elbl, L, Ferkl, R, Florian, J, Francek, L, Golan, L, Gregor, P, Honkova, M, Hubac, J, Jandik, J, Jarkovsky, P, Jelinek, Z, Jerabek, O, Jirmar, R, Kobza, R, Kochrt, M, Kostkova, G, 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M, Dinanian, S, Arfaoui, M, Hermida, J, Deruche, E, Kacet, S, Corbut, S, Poulard, J, Leparree, S, Roudaut, R, Duprat, C, Al Zoebi, A, Wurow, A, Bernhardt, P, Dichristin, U, Berrouschot, J, Vierbeck, S, Beyer Westendorf, J, Sehr, B, Bouzo, M, Schnelzer, P, Braun, R, Ladenburger, K, Buhr, M, Weihrauch, D, Contzen, C, Kara, M, Daut, W, Ayasse, D, Degtyareva, E, Kranz, P, Drescher, T, Herfurth, B, Faghih, M, Forck Boedeker, K, Schneider, K, Fuchs, R, Manuela, W, Grigat, C, Otto, A, Hartmann, A, Peitz, M, Heuer, H, Dieckheuer, U, Hoffmann, U, Dorn, S, Hoffmann, S, Schuppe, M, Horacek, T, Fink, P, Junggeburth, J, Schmid, S, Jungmair, W, Schoen, B, Kleinecke Pohl, U, Meusel, P, Koenig, H, Bauch, F, Lohrbaecher Kozak, I, Grosse, B, Lueders, S, Venneklaas, U, Luttermann, M, Wulf, M, Maus, O, Hoefer, K, Meissner, G, Braemer, U, Meyer Pannwitt, U, Frahm, E, Vogt, S, Muegge, A, Barbera, S, Mueller Glamann, M, Raddatz, K, Piechatzek, R, Lewinsky, D, Pohl, W, Proskynitopoulos, N, Kuhlmann, M, Rack, K, Pilipenko, H, Rinke, A, Kühlenborg, A, Schaefer, A, Szymanowski, N, Schellong, S, Frommhold, R, Schenkenberger, I, Finsterbusch, T, Dreykluft, K, Schiewe, C, Schmidt, A, Schmidt, M, Schreckenberg, A, Hellmers, J, Seibert, H, Gold, G, Sohn, H, Baylacher, M, Spitzer, S, Bonin, K, Stoehring, R, Taggeselle, J, Zarpentin, C, Veltkamp, R, Ludwig, I, Voehringer, Buchholz, M, Weyland, K, Winkelmann, B, Buelow Johansen, B, Wolde, C, Winter, K, Mavronasiou, E, Bourlios, P, Tziortziotis, A, Karamitsos, C, Exarchou, E, Kifnidis, K, Daskalaki, A, Moschos, N, Dimitra, K, Olympios, C, Kartsagkoulis, E, Pyrgakis, V, Korantanis, K, Ayau Milla, O, Ramirez Vde, L, Guzman Melgar, I, Jimenez, T, Ovando Lavagnino, A, Guevara, S, Rodas Estrada, M, Sanchez, M, Pozuelos, Jm, Sanchez Samayoa, C, Guerra, L, Velasquez Camas, L, Almaraz, Sp, Dioszeghy, P, Muskoczki, E, Edes, I, Szatmari, J, Fiok, J, Varga, A, Kanakaridisz, N, Kosztyu, M, Kis, E, Feil, Jf, Jakal, A, Koczka, M, Kovacs, I, Baranyai, M, Kovacs, Z, Lupkovics, G, Karakai, Hh, Matoltsy, A, Kiss, T, Medvegy, M, Kiss, K, Merkely, B, Kolumban, E, Nagy, A, Palinkas, A, Toth, Sr, Sayour, A, Bognar, A, Simor, T, Ruzsa, D, Sipos, T, Szakal, I, Tomcsanyi, J, Marosi, A, Vertes, A, Kincses, M, Malhan, S, Abdullakutty, J, Agarwal, D, Ranka, R, Arneja, J, Memon, A, Arora, V, Shree, R, Avvaru, G, Shaikh, A, Babu, P, Rao, B, Babu, R, Reddy, J, Banker, D, Sheth, T, Benjarge, P, Surushe, S, Bharani, A, Solanki, R, Bhargava, V, Rathi, A, Biniwale, A, Bhuti, M, Calambur, N, Karnwal, N, Chopda, M, Mali, N, Goyal, N, Saini, A, Gupta, J, Singh, P, Hadan, S, Savanth, P, Hardas, S, Thakor, G, Hiremath, J, Ghume, A, Jain, R, Pahuja, M, Joseph, S, Oommen, D, Joseph, J, Thomas, R, Joshi, H, Iby, Kale, V, Raut, N, Kandekar, B, Kandekar, S, Kishore, R, Krishnan, H, Kotiwale, V, Kulkarni, R, Deokar, M, Kulkarni, G, Lawande, A, Kumar, P, Karpuram, M, Kumar, A, Francis, J, Kumbla, M, Anthony, A, Lavhe, P, Kale, M, Mardikar, H, Bhaskarwar, P, Mathur, A, Sharma, 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Grammer, M.

Subjects
Male, Pyridines, [SDV]Life Sciences [q-bio], Embolism, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Edoxaban, Atrial Fibrillation, MESH: Double-Blind Method, 030212 general & internal medicine, MESH: Warfarin, Stroke, MESH: Aged, MESH: Middle Aged, Cardiovascular diseases [NCEBP 14], Hazard ratio, General Medicine, MESH: Follow-Up Studies, Middle Aged, 3. Good health, MESH: Atrial Fibrillation, Cardiovascular Diseases, Anesthesia, Cardiology, Female, Adult, Aged, Anticoagulants, Double-Blind Method, Follow-Up Studies, Hemorrhage, Humans, Thiazoles, Warfarin, MESH: Hemorrhage, Andexanet alfa, medicine.drug, medicine.medical_specialty, MESH: Enoxaparin, MESH: Anticoagulants, MESH: Stroke, Dabigatran, 03 medical and health sciences, Internal medicine, medicine, MESH: Kaplan-Meier Estimate, Rivaroxaban, MESH: Humans, business.industry, MESH: Cardiovascular Diseases, MESH: Adult, medicine.disease, Confidence interval, MESH: Male, chemistry, business, MESH: Female, MESH: Embolism
Abstract

Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P

Published
2013

50. Highly flexible and bendable carbon nanosheets as transparent conducting electrodes for organic solar cells

Author

Su-Young Son, Jin-Mun Yun, Yong-Jin Noh, Sungho Lee, Han-Ik Joh, Hae-Na Jo, and Seok-In Na

Subjects
Materials science, Organic solar cell, Graphene, Energy conversion efficiency, chemistry.chemical_element, Nanotechnology, General Chemistry, Substrate (electronics), Chemical vapor deposition, Exfoliation joint, law.invention, chemistry, law, General Materials Science, Carbon, Sheet resistance
Abstract

We synthesized highly flexible carbon nanosheets (CNSs) as transparent conducting electrodes (TCEs) suitable for flexible organic solar cells (OSCs). The flexible electrodes were obtained by transferring CNSs, which were synthesized on recyclable silicon wafers using a catalyst-free process, onto a polyethylene terephthalate substrate. The TCEs exhibited a sheet resistance of ∼2.5 kohm/sq. and a transmittance of 61% even after 200 bending cycles, leading to a high power conversion efficiency of approximately ∼1.33%, which is very high compared to that of flexible OSCs composed of pristine graphene generated by chemical vapor deposition or chemical exfoliation methods.

Published
2015

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