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193 results on '"NISHIHIRA, K."'

1. Characterization of lipidic coronary atheroma under control of low-density lipoprotein <1.8 mmol/l and lipoprotein (a) <50 mg/dl in patients with coronary artery disease

Author

Shishikura, D, primary, Kataoka, Y K, additional, Kusumoto, H K, additional, Yamauchi, Y Y, additional, Sakane, K S, additional, Fujisaka, T F, additional, Morita, H M, additional, Mitsui, K M, additional, Murai, K M, additional, Kitahara, S K, additional, Iwai, T I, additional, Nishihira, K N, additional, Takamisawa, I T, additional, Hoshiga, M H, additional, and Noguchi, T N, additional

Published
2023
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2. Cardiovascular outcomes, mortality, and bleeding in patients with acute myocardial infarction and a history of cancer: a report from the multi-center, nationwide prospective database JAMIR

Author

Adachi, A, primary, Oyama, K, additional, Takahashi, J, additional, Honda, S, additional, Nishihira, K, additional, Kojima, S, additional, Takegami, M, additional, Asaumi, Y, additional, Yamashita, J, additional, Kosuge, M, additional, Takayama, M, additional, Sumiyoshi, T, additional, Ogawa, H, additional, Kimura, K, additional, and Yasuda, S, additional

Published
2023
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4. Characterization of residual lipid-rich plaques despite achieving LDL-C <1.8mmol/l with a statin in patients with coronary artery disease: insights from the REASSURE-NIRS registry

Author

Kitahara, S, primary, Kataoka, Y, additional, Iwai, T, additional, Sawada, K, additional, Matama, H, additional, Honda, S, additional, Fujino, M, additional, Yoneda, S, additional, Takagi, K, additional, Nishihira, K, additional, Kanaya, T, additional, Otsuka, F, additional, Asaumi, Y, additional, Tsujita, K, additional, and Noguchi, T, additional

Published
2021
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7. Characterization of plaque features exhibiting physiological mismatch between fractional flow reserve and resting index: near-infrared spectroscopy imaging analysis

Author

Murai, K, primary, Kataoka, Y, additional, Hosoda, H, additional, Nakashima, T, additional, Honda, S, additional, Fujino, M, additional, Nakao, K, additional, Yoneda, S, additional, Otsuka, F, additional, Nishihira, K, additional, Kanaya, T, additional, Asaumi, Y, additional, Noguchi, T, additional, and Yasuda, S, additional

Published
2020
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8. Sex differences in door-to-balloon time and long-term adverse events after percutaneous coronary intervention for acute coronary syndrome: a sub-study from the Prospective JAMIR study

Author

Kimura, T, primary, Ito, T.I, additional, Honda, S, additional, Nishihira, K, additional, Kojima, S, additional, Takegami, M, additional, Asaumi, Y, additional, Suzuki, M, additional, Kosuge, M, additional, Takahashi, J, additional, Sakata, Y, additional, Takayama, M, additional, Sumiyoshi, T, additional, Kimura, K, additional, and Yasuda, S, additional

Published
2020
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13. P5635Predictive ability of lipdic burden for FFR-derived physiological measures: insights from near-infrared spectroscopy imaging analysis

Author

Murai, K, primary, Kataoka, Y, additional, Hirayama, A, additional, Hosoda, H, additional, Nakashima, T, additional, Honda, S, additional, Fujino, M, additional, Nakao, K, additional, Yoneda, S, additional, Otsuka, F, additional, Nishihira, K, additional, Kanaya, T, additional, Asaumi, Y, additional, Noguchi, T, additional, and Yasuda, S, additional

Published
2019
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14. P6198Lipoprotein(a) as a potential residual risk associated with coronary lipid-rich atheroma in type2 diabetic subjects with coronary artery disease who achieved lowdense lipoprotein cholesterol<1.7mmol/l

Author

Nakamura, H, primary, Kataoka, Y K, additional, Hosoda, H H, additional, Nakashima, T N, additional, Honda, S H, additional, Fujino, M F, additional, Nakao, K N, additional, Yoneda, S Y, additional, Otsuka, F O, additional, Nishihira, K N, additional, Kanaya, T K, additional, Asaumi, Y A, additional, Noguchi, T N, additional, and Yasuda, S Y, additional

Published
2019
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16. P639Triglyceride associated with cholesterol crystallization of atheroma in patients with coronary artery disease who received a statin: optical coherence tomographic analysis

Author

Usami, S., primary, Kataoka, Y., additional, Nakano, H., additional, Nakashima, T., additional, Kawakami, S., additional, Fujino, M., additional, Nakao, K., additional, Nagai, T., additional, Nishihira, K., additional, Kanaya, T., additional, Tahara, Y., additional, Asaumi, Y., additional, Noguchi, T., additional, Goto, Y., additional, and Yasuda, S., additional

Published
2017
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18. P6236Clinical characteristics and cardiovascular outcomes in subjects who developed acute myocardial infarction despite statin therapy

Author

Tsuda, K., primary, Kataoka, Y., additional, Nishikawa, R., additional, Doi, T., additional, Nakashima, T., additional, Kawakami, S., additional, Fujino, M., additional, Nakao, K., additional, Nishihira, K., additional, Kanaya, T., additional, Tahara, Y., additional, Asaumi, Y., additional, Noguchi, T., additional, Goto, Y., additional, and Yasuda, S., additional

Published
2017
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20. Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery

Author

Yamashita, A., Shoji, K., Tsuruda, T., Furukoji, E., Takahashi, M., Nishihira, K., Tamura, S., and Asada, Y.

Subjects
616 - Patología. Medicina clínica. Oncología, Macrophages, cardiovascular system, cardiovascular diseases, Atherosclerosis
Abstract

Expansive vascular remodeling is considered a feature of vulnerable plaques. Although inflammation is upregulated in the media and adventitia of atherosclerotic lesions, its contribution to expansive remodeling is unclear. We investigated this issue in injured femoral arteries of normo- and hyperlipidemic rabbits fed with a conventional (CD group; n=20) or a 0.5% cholesterol (ChD group; n=20) diet. Four weeks after balloon injury of the femoral arteries, we examined vascular wall alterations, localization of macrophages and matrix metalloproteases (MMP)-1, -2, -9, and extracellular matrix. Neointimal formation with luminal stenosis was evident in both groups, while expansive remodeling was observed only in the ChD group. Areas immunopositive for macrophages, MMP-1, -2 and -9 were larger not only in the neointima, but also in the media and/or adventitia in the injured arterial walls of the ChD, than in the CD group. Areas containing smooth muscle cells (SMCs), elastin and collagen were smaller in the injured arterial walls of the ChD group. MMP-1, -2 and -9 were mainly localized in infiltrating macrophages. MMP-2 was also found in SMCs and adventitial fibroblasts. Vasa vasorum density was significantly increased in injured arteries of ChD group than in those of CD group. These results suggest that macrophages in the media and adventitia play an important role in expansive atherosclerotic remodeling via extracellular matrix degradation and SMC reduction.

Published
2008

31. Serotonin induces vasoconstriction of smooth muscle cell‐rich neointima through 5‐hydroxytryptamine2Areceptor in rabbit femoral arteries

Author

NISHIHIRA, K., YAMASHITA, A., TANAKA, N., MORIGUCHI‐GOTO, S., IMAMURA, T., ISHIDA, T., KAWASHIMA, S., YAMAMOTO, R., KITAMURA, K., and ASADA, Y.

Abstract

Background: Smooth muscle cell (SMC)‐rich intima is a morphological feature of atherosclerotic lesions that is observed in eroded plaque and spastic arteries. Arteries with SMC‐rich intima are susceptible to vasoconstriction or vasospasm against some vasoactive agents. Objective: The present study evaluates the contribution of SMC‐rich intima to thrombogenic vasoconstriction. Methods: We established SMC‐rich neointima by damaging rabbit femoral arteries using balloons and then measured the isometric tension of the femoral strips against 5‐hydroxytryptamine (5‐HT), adenosine diphosphate, adenosine triphosphate and thrombin. Results: Among these agents, only 5‐HT induced a hypercontractile response of the injured arteries with SMC‐rich neointima, compared with non‐injured arteries. Smooth muscle cells of both the neointima and media expressed 5‐HT2Areceptor, and sarpogrelate, a selective 5‐HT2Areceptor antagonist significantly inhibited the hypercontraction. Furthermore, 5‐HT induced contraction of separated neointima and hypercontraction of separated media compared with non‐injured media. Sarpogrelate and fasudil, a specific Rho‐kinase inhibitor, significantly suppressed such contraction of both the neointima and media of injured arteries. Conclusions: These results suggest that 5‐HT plays a crucial role in thrombogenic vasoconstriction, and that SMC‐rich intima as well as media directly contributes to the hypercontractile response of atherosclerotic vessels through the 5‐HT2Areceptor and the Rho‐kinase pathway.

Published
2008
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32. Inhibition of 5‐hydroxytryptamine2Areceptor prevents occlusive thrombus formation on neointima of the rabbit femoral artery

Author

NISHIHIRA, K., YAMASHITA, A., TANAKA, N., KAWAMOTO, R., IMAMURA, T., YAMAMOTO, R., ETO, T., and ASADA, Y.

Abstract

Background: Thrombus propagation on disrupted plaque is a major cause of acute coronary events and serious complication after coronary intervention. 5‐hydroxytryptamine (5‐HT) is a potent vasoactive and platelet‐aggregating substance that is predominantly mediated by 5‐HT2Areceptor. However, the roles of 5‐HT2Areceptor in occlusive thrombus formation on disrupted plaque remain obscure. Objective: We investigated the role of 5‐HT2Areceptor in thrombus formation using a rabbit model of repeated balloon‐injury. Methods: Three weeks after a first balloon‐injury of the femoral arteries, luminal diameter, neointimal growth, and vasoconstriction by 5‐HT in vitrowere examined. Thrombus propagation and the role of 5‐HT2Areceptor after a second balloon‐injury were evaluated using sarpogrelate, a selective 5‐HT2Areceptor antagonist. Results: Three weeks after the first balloon‐injury, luminal stenosis was evident in the femoral arteries, where the neointima expressed tissue factor and 5‐HT2Areceptor. The hypercontractile response of the stenotic arteries to 5‐HT was significantly reduced by sarpogrelate. Balloon‐injury of the neointima with substantially reduced blood flow promoted the formation of occlusive thrombus that was immunoreactive against glycoprotein IIb‐IIIa, 5‐HT2Areceptor and fibrin. Intravenous injection of sarpogrelate significantly inhibited ex vivoplatelet aggregation induced by adenosine 5′‐diphosphate, thrombin and collagen alone as well as with 5‐HT, and significantly prevented occlusive thrombus formation in vivo. Conclusions: The 5‐HT2Areceptor appears to play a crucial role in occlusive thrombus formation in diseased arteries via platelet aggregation and vasoconstriction. Inhibition of 5‐HT2Areceptor might help reduce the onset of acute coronary events and of acute coronary occlusion after the intervention.

Published
2006
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35. BASIC RESEARCH ON PEROXIDE CURE

Author

Imoto, M., primary, Minoura, Y., additional, Goto, K., additional, Harada, H., additional, Nishihira, K., additional, Fujita, H., additional, Izuta, T., additional, Kono, K., additional, Fujioka, K., additional, Siota, A., additional, Oba, M., additional, Oshita, H., additional, and Usamoto, T., additional

Published
1968
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37. EFFECTS OF QUINONE DIOXIME ON THE PEROXIDE CURE OF ETHYLEN-PROPYLENE RUBBER

Author

Imoto, M., primary, Minoura, Y., additional, Goto, K., additional, Harada, H., additional, Nishihira, K., additional, Fugita, H., additional, Fugimoto, K., additional, Izuta, T., additional, Kiino, G., additional, Fugioka, K., additional, Shiota, A., additional, Oba, N., additional, Oshita, H., additional, Usamoto, T., additional, and Kubo, T., additional

Published
1968
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38. STUDIES ON THE ETHYLENE-PROPYLENE RUBBER POLYBLENDS

Author

Imoto, M., primary, Minoura, Y., additional, Goto, K., additional, Harada, H., additional, Nishihira, K., additional, Fujita, H., additional, Fujimoto, K., additional, Izuta, T., additional, Kono, K., additional, Fujioka, K., additional, Shiota, A., additional, Oba, M., additional, Oshita, H., additional, and Usamoto, T., additional

Published
1969
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40. Relationships between Chemical Structures of Crosslink Sites and Physical Properties of Vulcanized Rubbers. Part V. Analysis of Chemical Structures of Combined Sulfur in Crosslink Sites for Various EPDM Vulcanizates

Author

Imoto, M., primary, Minoura, Y., primary, Goto, K., primary, Harada, H., primary, Nishihira, K., primary, Fujita, H., primary, Fujimoto, K., primary, Izuta, T., primary, Kono, K., primary, Fujioka, K., primary, Shiota, A., primary, Oba, M., primary, Oshita, H., primary, and Usamoto, T., primary

Published
1970
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41. EPDM AND EPM IN THE PRESENCE RGANIC COMPOUNDS

Author

Imoto, M., primary, Minoura, Y., additional, Goto, K., additional, Harada, H., additional, Nishihira, K., additional, Fujita, H., additional, Fujimoto, K., additional, Izuta, T., additional, Kono, G., additional, Fujioka, K., additional, Shiota, A., additional, Oba, M., additional, Oshita, H., additional, and Usamoto, T., additional

Published
1969
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42. STUDIES ON THE ETHYLENE-PROPYLENE RUBBER BLENDS

Author

Imoto, M., primary, Minoura, Y., additional, Goto, K., additional, Harada, H., additional, Nishihira, K., additional, Fujita, H., additional, Fujimoto, K., additional, Izuta, T., additional, Kono, K., additional, Fujioka, K., additional, Shiota, A., additional, Oba, M., additional, Oshita, H., additional, and Usamoto, T., additional

Published
1969
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44. Relationships between Chemical Structures of Crosslink Sites and Physical Properties of Vulcanized Rubbers. Part VI. Oxidative Degradation of EPDM Vulcanizates

Author

Imoto, M., primary, Minoura, Y., primary, Goto, K., primary, Harada, H., primary, Nishihira, K., primary, Fujita, H., primary, Fujimoto, K., primary, Izuta, T., primary, Kono, K., primary, Fujioka, K., primary, Shiota, A., primary, Oba, M., primary, Oshita, H., primary, and Usamoto, T., primary

Published
1970
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46. Characteristics and In-Hospital Outcomes of Patients With Myocardial Infarction With Non-Obstructive Coronary Arteries　- Insights From the Real-World JAMIR Database.

Author

Onuma S, Takahashi J, Shiroto T, Godo S, Hao K, Honda S, Nishihira K, Kojima S, Takegami M, Sakata Y, Itoh T, Watanabe T, Watanabe M, Takayama M, Sumiyoshi T, Kimura K, and Yasuda S

Abstract

Background: Few studies have investigated the clinical characteristics and in-hospital outcomes of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) using real-world databases in the coronary intervention era., Methods and Results: We conducted a retrospective analysis of 22,236 patients (mean [±SD] age 68±13 years, 23.4% female) enrolled in the Japan Acute Myocardial Infarction Registry (JAMIR) between 2011 and 2016. Based on urgent coronary angiography findings, 286 (1.3%) patients were diagnosed as MINOCA, and the remaining 21,950 (98.7%) as MI with obstructive coronary artery disease (MI-CAD). MINOCA patients were characterized by younger age, fewer coronary risk factors, lower rate of ST-elevation myocardial infarction, lower Killip classification, and lower peak creatinine phosphokinase levels than MI-CAD patients. In-hospital all-cause mortality did not differ between the MINOCA and MI-CAD groups (5.2% vs. 5.7%, respectively; P=0.82). Comparing cause-specific mortality, non-cardiac mortality was higher in the MINOCA than MI-CAD group (4.2% vs. 1.6%; P<0.01). Importantly, non-cardiac death was more prevalent among elderly (≥65 years) than younger (<65 years) patients in the MI-CAD group, whereas this trend was not observed in the MINOCA group., Conclusions: Analysis of the real-world JAMIR database revealed a relatively high prevalence of non-cardiac death among MINOCA patients, underscoring the need for comprehensive management to improve disease prognosis, particularly in younger patients.

Published
2024
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47. Clinical Comparison of Drug-Coated Balloon and Drug-Eluting Stent for Femoropopliteal Lesions in Chronic Limb-Threatening Ischemia With Wounds.

Author

Ogata K, Nishihira K, Asano Y, Honda Y, Yamamoto K, Emori H, Kadooka K, Kimura T, Kudo T, Ashikaga K, Shibata Y, and Tsujita K

Subjects
Humans, Male, Female, Aged, Retrospective Studies, Middle Aged, Aged, 80 and over, Angioplasty, Balloon adverse effects, Angioplasty, Balloon instrumentation, Chronic Limb-Threatening Ischemia surgery, Coated Materials, Biocompatible, Wound Healing, Limb Salvage, Vascular Patency, Amputation, Surgical, Treatment Outcome, Drug-Eluting Stents, Popliteal Artery, Femoral Artery surgery, Peripheral Arterial Disease therapy
Abstract

Background: Endovascular therapy (EVT) with devices such as drug-coated balloons (DCBs) and drug-eluting stents (DESs) for atherosclerotic disease in the femoropopliteal (FP) artery has been established. However, EVT using drug-based devices for chronic limb-threatening ischemia (CLTI) remains challenging. The optimal device for FP lesions in patients with CLTI remains unknown. This study compared the clinical efficacy of DCB and DES in patients with CLTI and FP lesions., Methods and Results: This retrospective single-center study included 539 consecutive patients (562 lesions) treated with EVT between January 2018 and December 2022; 166 patients with CLTI and Rutherford Class 5 or 6 wounds underwent EVT with DCB or DES. Clinical outcomes were compared between 53 pairs after propensity score matching. There were no significant differences between the DCB and DES groups in the incidence of complete wound healing without death or major amputation (84.8% vs. 80.2%, respectively; P=0.99), primary patency (69.4% vs. 75.6%, respectively; P=0.65), and freedom from target lesion revascularization at 1 year (78.6% vs. 78.0%, respectively; P=0.92). Multivariate analysis showed that complete wound healing at 1 year is negatively associated with hemodialysis and Wound, Ischemia, and foot Infection Stage 4, but positively associated with Global Limb Anatomic Staging System FP Grade 3 or 4., Conclusions: No significant differences in clinical outcomes were found between DCB and DES for patients with CLTI and FP lesions.

Published
2024
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49. Basal inferoseptal segment is highly susceptible to deformation in the clinical spectrum of transthyretin-derived amyloid cardiomyopathy.

Author

Tsuruda T, Nakada H, Yamamura Y, Matsuura Y, Ogata M, Tanaka M, Suiko Y, Komaki S, Tanaka H, Moribayashi K, Ideguchi T, Terada T, Ota T, Yamamoto K, Nishihira K, Shibata Y, and Kaikita K

Abstract

Aims: While the prevalence of transthyretin-derived amyloid cardiomyopathy (ATTR-CM) is on the rise, detailed understanding of its morphological and functional characteristics within the left ventricle (LV) across heart failure (HF) remains limited., Methods and Results: Utilizing two-dimensional (2D) speckle-tracking echocardiography, we assessed longitudinal strain (LS) in 63 histology-confirmed ATTR-CM patients. Additionally, cardiac magnetic resonance (CMR) images measured native T1 and extracellular volume (ECV), compared with LS across 18 LV segments. Patients were categorized into three groups based on HF status: Group 1 (no HF symptoms), Group 2 (HF with preserved LV ejection fraction), and Group 3 (HF with reduced LV ejection fraction). LS analysis unveiled susceptibility to deformation in the basal inferoseptal segment, persisting even in asymptomatic cases. CMR demonstrated increasing native T1 deviation, particularly evident in segments distant from the inferoseptal region. Contrastingly, maximal ECV was consistently observed in the basal and mid-ventricular inferior-septum, even in asymptomatic individuals. Segmental LS decline correlated with ECV expansion but not with native T1 values., Conclusion: Our findings suggest that the inferoseptal segment is highly susceptible to amyloid infiltration, and 2D speckle-tracking echocardiography and CMR may serve as a valuable tool for its early detection., Competing Interests: Conflict of interest: T.T. received lecture fees from Pfizer Japan Inc and Alnylam Japan. K.K. received lecture fees from Bayer Yakuhin, Daiichi-Sankyo, Novartis Pharma AG, Otsuka Pharmaceutical, Bristol-Myers K.K., and Kowa, as well as scholarship funds from Abbott Medical., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2024
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50. Clinical outcomes of adjusted-dose versus standard-dose prasugrel in East Asian patients with acute myocardial infarction.

Author

Honda S, Lee S, Cho KH, Takegami M, Nishihira K, Kojima S, Asaumi Y, Saji M, Yamashita J, Hibi K, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Sim DS, Kim HK, Kim W, Ahn Y, Jeong MH, and Yasuda S

Subjects
Aged, Female, Humans, Male, Middle Aged, Cohort Studies, Dose-Response Relationship, Drug, East Asian People, Hemorrhage chemically induced, Hemorrhage epidemiology, Japan epidemiology, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors adverse effects, Registries, Republic of Korea epidemiology, Treatment Outcome, Myocardial Infarction epidemiology, Percutaneous Coronary Intervention methods, Prasugrel Hydrochloride administration & dosage, Prasugrel Hydrochloride adverse effects
Abstract

Background: The comparative efficacy and safety of adjusted- and standard-dose prasugrel in East Asian patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) remain unclear. This study aimed to comparatively assess the ischaemic and bleeding outcomes of adjusted-dose (maintenance dose: 3.75 mg) and standard-dose (maintenance dose: 10 mg) prasugrel in East Asian patients with AMI undergoing PCI., Methods: From a combined dataset sourced from nationwide AMI registries in Japan and South Korea (n = 17,118), patients treated with either adjusted- or standard-dose prasugrel were identified. Patients who did not undergo emergent PCI, those on oral anticoagulants, and those meeting the criteria of contraindication of prasugrel in South Korea (age ≥ 75 years, body weight < 60 kg, or history of stroke) were excluded. Major adverse cardiovascular events (MACE) and Thrombolysis in Myocardial Infarction (TIMI) major bleeding events were compared between the adjusted-dose (n = 1160) and standard-dose (n = 1086) prasugrel groups., Results: Within the propensity-matched cohort (n = 702 in each group), no significant difference was observed in the in-hospital MACE between the adjusted- and standard-dose prasugrel groups (1.85% vs. 2.71%, odds ratio [OR] 0.68, 95% confidence interval [CI] 0.33-1.38, p = 0.286). However, the incidence of in-hospital major bleeding was significantly lower in the adjusted-dose prasugrel group than in the standard-dose group (0.43% vs. 1.71%, OR 0.25, 95% CI 0.07-0.88, p = 0.031). The cumulative 12-month incidence of MACE was equivalent in both groups (4.70% vs. 4.70%, OR 1.00, 95% CI 0.61-1.64, p = 1.000)., Conclusions: Among East Asian patients with AMI undergoing PCI, those administered adjusted-dose prasugrel exhibited a lower risk of in-hospital bleeding events than those administered standard-dose prasugrel, while maintaining a comparable 1-year incidence of MACE., Competing Interests: Declaration of competing interest Dr. Yasuda reports remuneration for lectures from Takeda, Daiichi Sankyo, and Bristol-Myers Squibb and trust research/joint research funds from Takeda and Daiichi Sankyo; Dr. Takayama reports lecture fees from Daiichi Sankyo; and Dr. Ogawa reports lecture fees and research grants from Abbot Medical Japan, Bayer, Daiichi Sankyo, Eisai, Kowa, Takeda Pharmaceutical, and Teijin. Other authors have no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2024
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