1. Anatomy and physiology of the male reproductive system and potential targets of toxicants
- Author
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Johnson, L., Ing, N.H., Curley, K.O., Graham, J., Welsh, T.H., STAUB, Christophe, Texas A&M University System, Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (Unité Expérimentale de Physiologie Animale de l‘Orfrasiére - UE PAO), Institut National de la Recherche Agronomique (INRA), NIH R25 ES 10735, NSF GK-12 0638738, NIH R25 RR 022711, Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO), and Michael Caplan (Editeur)
- Subjects
0301 basic medicine ,germ cells ,steroidogenesis ,[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT] ,anatomy ,Spermiogenesis ,media_common.quotation_subject ,sertoli cells ,testicular hormones ,Physiology ,excurrent ducts ,Semen ,physiologie de la reproduction ,Biology ,testis ,03 medical and health sciences ,chemistry.chemical_compound ,toxicant ,mâle ,0302 clinical medicine ,pituitary hormones ,Reproductive biology ,comportement sexuel ,meiosis ,hypothalamus ,Testicular Hormones ,hypothalamic neurohormones ,media_common ,pituitary gland ,toxic substances ,myoid cells ,standing reflex ,Anatomy ,accessory sex glands ,substance toxique ,spermatogenesis ,anatomie ,030104 developmental biology ,chemistry ,physiology ,Spermatocytogenesis ,leydig cells ,Reproduction ,système reproducteur ,Spermatogenesis ,030217 neurology & neurosurgery ,Toxicant - Abstract
Toxicology of Reproductive and Endocrine System; This introductory chapter offers a basic overview of male reproduction, specifically the anatomy and physiology of the male reproductive system. Comprehension of normal anatomy and physiology is necessary to (1) fully understand the severity of toxicant-induced damage to structures and/or functions of the male reproductive system, (2) design more powerful experiments that analyze potential male reproductive toxicants, and (3) identify numerous potential targets of toxicants in the male reproductive system. This chapter begins with an overview of the hypothalamic-pituitary-testicular axis and its interaction with additional components of the male reproductive system. This is then followed by detailed presentation of the composition of the testis and the interrelationships of the testicular cells, spermatogenesis, the excurrent ducts that carry spermatozoa out of the testis, the accessory sex glands that supply the seminal plasma of semen, the cellular communication within the testis, the reproductive tract's development, and normal male sexual behavior. The chapter's conclusion emphasizes the foundational importance of the male reproductive system to desgining, conducting, and interpreting reproductive toxicology research.
- Published
- 2015