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6. Medical Informatics and Data Analysis.

Author

Nieminen, Pentti and Nieminen, Pentti

Subjects
Medicine, Active Contour Models, GLM, GVF, ICD coding, Iterative simulation, Long-term care (LTC), Monte Carlo, South Korean female, Type I error, age-dependent stretched exponent, biostatistics, bird swarm algorithm, case study, castration-resistant prostate cancer, cervical injury, characteristic life, compartmental model, data analysis, data anonymization, data mining, data presentation, decision support system, deep belief network, deep learning, diabetes control, electronic healthcare, health, health care, heart disease diagnosis, heuristic approach, hierarchical classification, importance-satisfaction (I-S) model, inertial sensors, mathematical models, maximum lifespan, medical informatics, medicine, mobile assistant, modified stretched exponential function, n/a, neck pain, neck surface accelerometer, performance evaluation matrix (PEM), phased long short-term memory, power simulation, prostate cancer, prostate imaging, publications, reporting, retirement threshold, service quality performance matrix (SQPM), skewed data, snake segmentation, software tool, sparse FCM, statistical computing, statistics, surgery scheduling, t-test, vocal distance dose, vocal fatigue, voice of customer (VOC)
Abstract

Summary: During recent years, the use of advanced data analysis methods has increased in clinical and epidemiological research. This book emphasizes the practical aspects of new data analysis methods, and provides insight into new challenges in biostatistics, epidemiology, health sciences, dentistry, and clinical medicine. This book provides a readable text, giving advice on the reporting of new data analytical methods and data presentation. The book consists of 13 articles. Each article is self-contained and may be read independently according to the needs of the reader. The book is essential reading for postgraduate students as well as researchers from medicine and other sciences where statistical data analysis plays a central role.

11. Initiative on #4openScienceStandsForUkraine scientists and students

Author

Brücher Björn LDM, Brembs Björn, Bartsch Detlef, Przygodzki Ronald, Gosselin Romain-Daniel, Rupnik Marijan Slak, Calu Valentin, Birkenmaier Christof, Hayden Oliver, Schmidt Annette, Elias Nelson, Stein Hubert J, Restrepo Cesar, Pliquett Rainer U, Petersen Björn, Spychalla Arkadiusz, Nguyen David H, Santos Lúcio Lara, Szold Amir, Tez Mesut, Roviello Franco, Macri Paolo, Loroch Vanya, Scherer Michael A, Pasche Boris, Polom Karol, Wesarg Stefan, Matevossian Edouard, Zilberstein Bruno, Kryvoruchko Igor A, Correia da Costa José M, Nigri Giuseppe, Weissig Volkmar, Ralon Sergio, Kermansaravi Mohammad, Oleas Raúl, Seno Masaharu, Baum Michael, Voskuil Jan, Mintz Yoav, Rödiger Stefan, Schueler Gudrun, Kühn Hartmut, Delrio Paolo, Wallner Grzegorz, Rivkind Avraham, Nieminen Pentti, Armstrong David G, Schlegel Martin P, Daumer Martin, Ööpik Vahur, Araujo Raimund JC, Lapeña Jose Florencio F, Perkins Ray, Anogianakis Georgios, Salber Jochen, Tenne Reshef, and Jamall Ijaz S

Subjects
Medicine, Science
Published
2022
Full Text
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27. 2022 4open Initiative to support Ukraine scientists and students

Author

Brembs, Bj��rn, Bartsch, Detlef, Przygodzki, Ronald, Romain-Daniel Gosselin, Rupnik, Marjan Slak, Calu, Valentin, Birkenmaier, Christof, Hayden, Oliver, Schmidt, Annette, Elias, Nelson, Stein, Hubert, Restrepo, Cesar, Pliquett, Rainer U, Petersen, Bj��rn, Spycha��a, Arkadiusz, Nguyen, David, Santos, Lucio Lara, Szold, Amir, Tez, Mesut, Roviello, Franco, Macri, Paolo, Loroch, Vanya, Scherer, Michael A, Pasche, Boris, Kryvoruchko, Igor A., Da Costa, Jos�� Manuel Correia, Nigri, Giuseppe, Weissig, Volkmar, Ralon, Sergio, Kermansaravi, Mohammad, Oleas, Ra��l, Seno, Masaharu, Baum, Michael, Voskuil, Jan, Mintz, Yoav, R��diger, Stefan, Schueler, Gudrun, K��hn, Hartmut, Delrio, Paolo, Wallner, Grzegorz, Rivkind, Avraham I, Nieminen, Pentti, Armstrong, David G., Schlegel, Martin, Daumer, Martin, ����pik, Vahur, Junior, Raimundo Araujo, Lapena, Jose Florencio Fabella, Perkins, Ray, Anogianakis, Georgios, Salber, Jochen, Tenne, Reshef, Jamall, Ijaz S., and Br��cher, Bj��rn L.D.M.

Published
2022
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36. Sputum Vitamin D Binding Protein (VDBP) GC1S/1S Genotype Predicts Airway Obstruction: A Prospective Study in Smokers with COPD

Author

Gao,Jing, Törölä,Tanja, Li,Chuan-Xing, Ohlmeier,Steffen, Toljamo,Tuula, Nieminen,Pentti, Hattori,Noboru, Pulkkinen,Ville, Iwamoto,Hiroshi, Mazur,Witold, Gao,Jing, Törölä,Tanja, Li,Chuan-Xing, Ohlmeier,Steffen, Toljamo,Tuula, Nieminen,Pentti, Hattori,Noboru, Pulkkinen,Ville, Iwamoto,Hiroshi, and Mazur,Witold

Abstract

Jing Gao,1,* Tanja Törölä,1,* Chuan-Xing Li,2 Steffen Ohlmeier,3 Tuula Toljamo,4 Pentti Nieminen,5 Noboru Hattori,6 Ville Pulkkinen,1 Hiroshi Iwamoto,6 Witold Mazur1 1Heart and Lung Centre, Department of Pulmonary Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; 2Pulmonomics Group, Respiratory Medicine Unit, Department of Medicine & Centre for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; 3Proteomics Core Facility, Biocentre Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland; 4Department of Pulmonary Medicine, Lapland Central Hospital, Rovaniemi, Finland; 5Medical Informatics and Statistics Group, University of Oulu, Oulu, Finland; 6Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan*These authors contributed equally to this workCorrespondence: Jing GaoHeart and Lung Centre, Department of Pulmonary Medicine, University of Helsinki and Helsinki University Hospital, FinlandTel +358417071559Email jing.gao@helsinki.fi, HelsinkiIntroduction: The vitamin D binding protein (VDBP, also known as GC-globulin) and vitamin D deficiency have been associated with chronic obstructive pulmonary disease (COPD). rs7041 and rs4588 are two single nucleotide polymorphisms of the VDBP gene, including three common allelic variants (GC1S, GC1F and GC2). Previous studies primarily assessed the serum levels of vitamin D and VDBP in COPD. However, less is known regarding the impact of the local release of VDBP on COPD lung function. Thus, we examined the association of sputum and plasma VDBP with lung function at baseline and at four years, and examined potential genetic polymorphism interactions.Methods: The baseline levels of sputum VDBP, plasma VDBP and plasma 25-OH vitamin D, as well as the GC rs4588 and rs7041 genotypes, were assessed in a 4-year Finnish follow-up cohort (n = 233) of non-smoke

Published
2020

41. Links between creativity and mental disorder

Author

Lauronen, Erika, Veijola, Juha, Isohanni, Irene, Jones, Peter B., Nieminen, Pentti, and Isohanni, Matti

Subjects
Creative ability, Mental illness, Psychology and mental health
Abstract

A link between mental disorder and decreased ability is commonly assumed, but evidence to the contrary also exists. In reviewing any association between creativity and mental disorder, our aim is not only to update the literature but also to include an epidemiological and theoretical discussion of the topic. For literature retrieval, we used Medline, PsycINFO, and manual literature searches. Studies are numerous: most are empirical, many having methodological difficulties and variations in definitions and concepts. There is little consensus. However, some trends are apparent. We found 13 major case series (over 100 cases), case-control studies, or population-based studies, with valid, reliable measures of mental disorders. The results of all but one of these studies supported the association, at least when concerning particular groups of mental disorders; the findings were somewhat unclear in two studies. Most of the remainder that are not included in our more detailed examination also show a fragile association between creativity and mental disorder, but the link is not apparent for all groups of mental disorders or for all forms of creativity. In conclusion, evidence exists to support some form of association between creativity and mental disorder, but the direction of any causal link remains obscure.

Published
2004

46. Use of statistical techniques in studies of suicide seasonality, 1970 to 1997

Author

Hakko, Helina, Rasanen, Pirkko, Tiihonen, Jari, and Nieminen, Pentti

Subjects
Suicide -- Environmental aspects, Seasonal affective disorder -- Research, Psychology and mental health
Abstract

The effect of seasons on suicides has been suggested repeatedly. In order to reveal a true seasonal pattern, an appropriate statistical technique, which is sensitive to a specific type of cyclic variation in the data, must be chosen. This study is a review of the use of statistical techniques for seasonality and of some important characteristics of study samples that were evaluated from 46 original suicide seasonality articles published in major psychiatric journals. The results showed that statistical techniques were applied in a majority of articles, but they were commonly lacking regarding analyses, which compared seasonal patterns among subgroups of a population. In recent studies more sophisticated statistical techniques were utilized for seasonality, like spectral analyses, as compared with earlier studies, in which the emphasis was on chi-square tests. Lack of reporting essential features of the data, such as the sample size and monthly values of suicides, were frequent. The calendar effect was adjusted only in 11 studies. Some recommendations concerning the methodological and reporting issues are summarized for future articles on the seasonal affect on suicides.

Published
2002

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