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1. Humoral antibody response following mRNA vaccines against SARS-CoV-2 in solid organ transplant recipients; a status after a fifth and bivalent vaccine dose

Author

Emma Christophorou, Anna Christine Nilsson, Inge Petersen, Susan O. Lindvig, Jesper R. Davidsen, Rozeta Abazi, Mikael K. Poulsen, Rune M. Pedersen, Ulrik S. Justesen, Nicolai E. Johansen, Claus Bistrup, Lone W. Madsen, and Isik S. Johansen

Subjects
COVID-19 vaccination, solid organ transplant, humoral response, fifth dose, bivalent vaccines, BA.1, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundIn solid organ transplant (SOT) recipients, the humoral response following COVID-19 vaccination is reduced, as a result of their immunosuppressed treatment. In this study, we investigated antibody concentrations after booster vaccinations until the fifth dose, the latter by monovalent or bivalent BA1 or BA4/5 vaccines. In addition, we evaluated the efficacy of vaccination by recording breakthrough infections, hospitalizations, and deaths.MethodThis prospective cohort study included 438 SOT recipients (>18 years) vaccinated with mRNA vaccines against COVID-19 from January 2021 until March 2023. Blood samples were drawn before and after each vaccination and tested for SARS-CoV-2 spike RBD IgG antibodies with the lowest and highest cut-off at 7.1 and 5,680 BAU/mL, respectively. Vaccine information, breakthrough infections, and hospitalizations were collected from the medical records.ResultsMost participants received BNT162b2 and 61.4% received five vaccine doses. The response proportion in SOT recipients increased from 86.7% after the fourth dose to 93.0% following the fifth dose. Antibody concentration decreased with 142.7 BAU/mL between the third and fourth dose (median 132 days, Quartile 1: 123, Quartile 3: 148) and 234.3 BAU/mL between the fourth and fifth (median 250 days, Quartile 1: 241, Quartile 3: 262) dose among those without breakthrough infection (p=0.34). When comparing the Omicron BA.1 or Omicron BA.4/BA.5 adapted vaccines, no significant differences in antibody concentration were found, but 20.0% of SOT recipients receiving a monovalent fifth vaccine dose had a breakthrough infection compared to 4.0% and 7.9% among those who received BA.1 and BA.4/BA.5 adapted vaccines, respectively (p=0.04). Since January 2021, 240 (54.8%) participants had a breakthrough infection, and 22 were hospitalized, but no deaths were observed.ConclusionsThe fifth COVID-19 vaccine dose raised antibody response to 93.0% of the study population. Additional booster doses, as well as bivalent vaccines, led to higher levels of antibody concentration in SOT recipients. We found a lower incidence of breakthrough infections among SOT recipients after receiving a bivalent vaccine as a fifth dose compared to those receiving a monovalent dose. Antibody concentrations did not wane when the time between doses was prolonged from four to eight months.

Published
2023
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4. Follow-up and comparative assessment of SARS-COV-2 IGA, IGG, neutralizing, and total antibody responses after BNT162B2 or MRNA-1273 heterologous booster vaccination

Author

Younes, S., primary, Nicolai, E., additional, Pieri, M., additional, Sergio, B., additional, Daas, H.I., additional, Al-Sadeq, D.W., additional, Younes, N., additional, Shurrab, F.M., additional, Nizamuddin, P., additional, Humaira, F., additional, Al-Dewik, N., additional, Yassine, H.M., additional, Abu-Raddad, L.J., additional, Ismail, A., additional, and Nasrallah, G., additional

Published
2024
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5. Wastewater-based epidemiology surveillance as an early warning system for SARS-CoV-2 in Indonesia

Author

Nicolai, E, Murni, IK, Oktaria, V, McCarthy, DT, Supriyati, E, Nuryastuti, T, Handley, A, Donato, CM, Wiratama, BS, Dinari, R, Laksono, IS, Thobari, JA, Bines, JE, Nicolai, E, Murni, IK, Oktaria, V, McCarthy, DT, Supriyati, E, Nuryastuti, T, Handley, A, Donato, CM, Wiratama, BS, Dinari, R, Laksono, IS, Thobari, JA, and Bines, JE

Abstract

BACKGROUND: Wastewater-based epidemiology (WBE) surveillance has been proposed as an early warning system (EWS) for community SARS-CoV-2 transmission. However, there is limited data from low-and middle-income countries (LMICs). This study aimed to assess the ability of WBE surveillance to detect SARS-CoV-2 in formal and informal environments in Indonesia using different methods of sample collection, to compare WBE data with patterns of clinical cases of COVID-19 within the relevant communities, and to assess the WBE potential to be used as an EWS for SARS-CoV-2 outbreaks within a community. MATERIALS AND METHODS: We conducted WBE surveillance in three districts in Yogyakarta province, Indonesia, over eleven months (27 July 2021 to 7 January 2022 [Delta wave]; 18 January to 3 June 2022 [Omicron wave]). Water samples using grab, and/or passive sampling methods and soil samples were collected either weekly or fortnightly. RNA was extracted from membrane filters from processed water samples and directly from soil. Reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) was performed to detect the SARS-CoV-2 N and ORF1ab genes. RESULTS: A total of 1,582 samples were collected. Detection rates of SARS-CoV-2 in wastewater reflected the incidence of community cases, with rates of 85% at the peak to 2% at the end of the Delta wave and from 94% to 11% during the Omicron wave. A 2-week lag time was observed between the detection of SARS-CoV-2 in wastewater and increasing cases in the corresponding community. CONCLUSION: WBE surveillance for SARS-CoV-2 in Indonesia was effective in monitoring patterns of cases of COVID-19 and served as an early warning system, predicting the increasing incidence of COVID-19 cases in the community.

Published
2024

7. 2-deoxy-2[F-18] fluoro-D-glucose positron emission tomography Deauville scale and core-needle biopsy to determine successful management after six doxorubicin, bleomycin, vinblastine and dacarbazine cycles in advanced-stage Hodgkin lymphoma

Author

Picardi, M., Fonti, R., Della Pepa, R., Giordano, C., Pugliese, N., Nicolai, E., Salvatore, M., Mainolfi, C., Venetucci, P., Rascato, M.G., Cappuccio, I., Mascolo, M., Vigliar, E., Troncone, G., Del Vecchio, S., and Pane, F.

Published
2020
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9. Humoral antibody response following mRNA vaccines against SARS-CoV-2 in solid organ transplant recipients; a status after a fifth and bivalent vaccine dose

Author

Christophorou, Emma, primary, Nilsson, Anna Christine, additional, Petersen, Inge, additional, Lindvig, Susan O., additional, Davidsen, Jesper R., additional, Abazi, Rozeta, additional, Poulsen, Mikael K., additional, Pedersen, Rune M., additional, Justesen, Ulrik S., additional, Johansen, Nicolai E., additional, Bistrup, Claus, additional, Madsen, Lone W., additional, and Johansen, Isik S., additional

Published
2023
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11. New Identification Approach and Methods for Plasma Equilibrium Reconstruction in D-Shaped Tokamaks

Author

Yuri V. Mitrishkin, Pavel S. Korenev, Artem E. Konkov, Valerii I. Kruzhkov, and Nicolai E. Ovsiannikov

Subjects
tokamak, plasma equilibrium reconstruction, linear plasma models, identification, state observer, LMI, Mathematics, QA1-939
Abstract

The paper deals with the identification of plasma equilibrium reconstruction in D-shaped tokamaks on the base of plasma external magnetic measurements. The methods of such identification are directed to increase their speed of response when plasma discharges are relatively short, like in the spherical Globus-M2 tokamak (Ioffe Inst., St. Petersburg, Russia). The new approach is first to apply to the plasma discharges data the off-line equilibrium reconstruction algorithm based on the Picard iterations, and obtain the gaps between the plasma boundary and the first wall, and the second is to apply new identification methods to the gap values, producing plasma shape models operating in real time. The inputs for on-line robust identification algorithms are the measurements of magnetic fluxes on magnetic loops, plasma current, and currents in the poloidal field coils measured by the Rogowski loops. The novel on-line high-performance identification algorithms are designed on the base of (i) full-order observer synthesized by linear matrix inequality (LMI) methodology, (ii) static matrix obtained by the least square technique, and (iii) deep neural network. The robust observer is constructed on the base of the LPV plant models which have the novelty that the state vector contains the gaps which are estimated by the observer, using input and output signals. The results of the simulation of the identification systems on the base of experimental data of the Globus-M2 tokamak are presented.

Published
2021
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12. Digital Governance

Author

Hanisch, Marvin, Goldsby, Curtis, Fabian, Nicolai E., Oehmichen, Jana, and Department of Technology and Operations Management

Subjects
Marketing, Digital transformation, Artificial intelligence, Blockchain, Corporate governance, Algorithmic management, Interorganizational governance, Digital governance
Abstract

The rapid expansion of digital technologies has paved the way for new forms of organizing, facilitated by increased data and knowledge exchange between individuals and organizations. However, this poses major new challenges for designing effective governance mechanisms. This paper highlights the critical role of digital governance in facilitating digitally enabled exchange relationships. To this end, we propose a typology of analog, augmented, and automated governance modes, each associated with specific control, coordination, incentive, and trust mechanisms. Additionally, we provide a heuristic for determining the optimal governance choice via the interplay of transactivity (i.e., the contributors, connections, and consistency in an exchange network) and corresponding governance costs. Our study advances the governance literature by defining digital governance as a distinct form and outlining key governance mechanisms and choices in the digital era. Finally, we identify avenues for future research in this field.

Published
2023

16. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

Author

Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, A, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, M, Deandreis, D, Dottorini, M, Esposito, F, Farsad, M, Gasparini, M, Grana, C, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, M, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, M, Marzola, M, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, A, Durmo, R, Vellani, C, Ceriani, V, Albano D., Bertagna F., Alongi P., Baldari S., Baldoncini A., Bartolomei M., Boccaletto F., Boero M., Borsatti E., Bruno A., Burroni L., Capoccetti F., Castellani M., Cervino A. R., Chierichetti F., Ciarmiello A., Corso A., Cuocolo A., De Rimini M. L., Deandreis D., Dottorini M. E., Esposito F., Farsad M., Gasparini M., Grana C. M., Gregianin M., Guerra L., Loreti F., Lupi A., Martino G., Milan E., Modoni S., Morbelli S., Muni A., Nicolai E., Palumbo B., Papa S., Papaleo A., Pellerito R., Poti C., Romano P., Rossetti C., Rossini P., Rubini G., Ruffini L., Sacchetti G., Savelli G., Schiavariello S., Sciagra R., Sciuto R., Seregni E., Sestini S., Sicolo M., Spanu A., Storto G., Balducci M. T., Trifiro G., Versari A., Vignati A., Volterrani D., Calcagni M. L., Marzola M. C., Garufo A., Evangelista L., Maroldi R., Schillaci O., Giubbini R., Bonacina M., Laudicella R., Spallino M., Palucci A., Cuzzocrea M., Donner M., Maurea S., Ceci F., Dei Rossi F., Tranfaglia B., Sartorello A., Gandolfo P., Buschiazzo A., Scarale A., Kirienko M., Merenda N., Nappi A. G., Durmo R., Vellani C., Ceriani V., Albano, D, Bertagna, F, Alongi, P, Baldari, S, Baldoncini, A, Bartolomei, M, Boccaletto, F, Boero, M, Borsatti, E, Bruno, A, Burroni, L, Capoccetti, F, Castellani, M, Cervino, A, Chierichetti, F, Ciarmiello, A, Corso, A, Cuocolo, A, De Rimini, M, Deandreis, D, Dottorini, M, Esposito, F, Farsad, M, Gasparini, M, Grana, C, Gregianin, M, Guerra, L, Loreti, F, Lupi, A, Martino, G, Milan, E, Modoni, S, Morbelli, S, Muni, A, Nicolai, E, Palumbo, B, Papa, S, Papaleo, A, Pellerito, R, Poti, C, Romano, P, Rossetti, C, Rossini, P, Rubini, G, Ruffini, L, Sacchetti, G, Savelli, G, Schiavariello, S, Sciagra, R, Sciuto, R, Seregni, E, Sestini, S, Sicolo, M, Spanu, A, Storto, G, Balducci, M, Trifiro, G, Versari, A, Vignati, A, Volterrani, D, Calcagni, M, Marzola, M, Garufo, A, Evangelista, L, Maroldi, R, Schillaci, O, Giubbini, R, Bonacina, M, Laudicella, R, Spallino, M, Palucci, A, Cuzzocrea, M, Donner, M, Maurea, S, Ceci, F, Dei Rossi, F, Tranfaglia, B, Sartorello, A, Gandolfo, P, Buschiazzo, A, Scarale, A, Kirienko, M, Merenda, N, Nappi, A, Durmo, R, Vellani, C, Ceriani, V, Albano D., Bertagna F., Alongi P., Baldari S., Baldoncini A., Bartolomei M., Boccaletto F., Boero M., Borsatti E., Bruno A., Burroni L., Capoccetti F., Castellani M., Cervino A. R., Chierichetti F., Ciarmiello A., Corso A., Cuocolo A., De Rimini M. L., Deandreis D., Dottorini M. E., Esposito F., Farsad M., Gasparini M., Grana C. M., Gregianin M., Guerra L., Loreti F., Lupi A., Martino G., Milan E., Modoni S., Morbelli S., Muni A., Nicolai E., Palumbo B., Papa S., Papaleo A., Pellerito R., Poti C., Romano P., Rossetti C., Rossini P., Rubini G., Ruffini L., Sacchetti G., Savelli G., Schiavariello S., Sciagra R., Sciuto R., Seregni E., Sestini S., Sicolo M., Spanu A., Storto G., Balducci M. T., Trifiro G., Versari A., Vignati A., Volterrani D., Calcagni M. L., Marzola M. C., Garufo A., Evangelista L., Maroldi R., Schillaci O., Giubbini R., Bonacina M., Laudicella R., Spallino M., Palucci A., Cuzzocrea M., Donner M., Maurea S., Ceci F., Dei Rossi F., Tranfaglia B., Sartorello A., Gandolfo P., Buschiazzo A., Scarale A., Kirienko M., Merenda N., Nappi A. G., Durmo R., Vellani C., and Ceriani V.

Abstract

Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

Published
2021

21. Erratum: Handedness side and magnetization transfer ratio in the primary sensorimotor cortex central sulcus (BioMed Research International (2019) 2019 (5610849) DOI: 10.1155/2019/5610849)

Author

Mascalchi M., Ciulli S., Bianchi A., Marzi C., Orsolini S., Gavazzi G., Aiello M., Nicolai E., Soricelli A., Giannelli M., Diciotti S., Mascalchi M., Ciulli S., Bianchi A., Marzi C., Orsolini S., Gavazzi G., Aiello M., Nicolai E., Soricelli A., Giannelli M., and Diciotti S.

Subjects
not applicable
Abstract

In the article titled "Handedness side and magnetization transfer ratio in the primary sensorimotor cortex central sulcus" [1], affiliation 3 was incorrect. The correct affiliation is "IRCCS SDN, Naples, Italy," and it is corrected above.

Published
2020

24. Sevoflurane Sparing Effect of Morphine in Tegus (Salvator merianae) – A Preliminary Study

Author

Adriano Bonfim Carregaro, Thais Feres Bressan, Nathalia Villaça Xavier, André Nicolai E. Silva, André Augusto Justo, Vitor Yuji Myiashiro, and Mariana Cardoso Sanches

Subjects
Methyl Ethers, Sevoflurane, Cross-Over Studies, Morphine, Anesthetics, Inhalation, Animals, Lizards, Prospective Studies, Small Animals
Abstract

This study aimed to determine the minimum anesthetic concentration (MAC) of sevoflurane in tegus (Salvator merianae) and the morphine-sparing effect on this variable. In a prospective, non-blinded, crossover study, MAC was first determined in 6 tegus under sevoflurane anesthesia alone (MAC

Published
2022
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27. Dexamethasone alleviates tumor-associated brain damage and angiogenesis.

Author

Zheng Fan, Tina Sehm, Manfred Rauh, Michael Buchfelder, Ilker Y Eyupoglu, and Nicolai E Savaskan

Subjects
Medicine, Science
Abstract

Children and adults with the most aggressive form of brain cancer, malignant gliomas or glioblastoma, often develop cerebral edema as a life-threatening complication. This complication is routinely treated with dexamethasone (DEXA), a steroidal anti-inflammatory drug with pleiotropic action profile. Here we show that dexamethasone reduces murine and rodent glioma tumor growth in a concentration-dependent manner. Low concentrations of DEXA are already capable of inhibiting glioma cell proliferation and at higher levels induce cell death. Further, the expression of the glutamate antiporter xCT (system Xc-; SLC7a11) and VEGFA is up-regulated after DEXA treatment indicating early cellular stress responses. However, in human gliomas DEXA exerts differential cytotoxic effects, with some human glioma cells (U251, T98G) resistant to DEXA, a finding corroborated by clinical data of dexamethasone non-responders. Moreover, DEXA-resistant gliomas did not show any xCT alterations, indicating that these gene expressions are associated with DEXA-induced cellular stress. Hence, siRNA-mediated xCT knockdown in glioma cells increased the susceptibility to DEXA. Interestingly, cell viability of primary human astrocytes and primary rodent neurons is not affected by DEXA. We further tested the pharmacological effects of DEXA on brain tissue and showed that DEXA reduces tumor-induced disturbances of the microenvironment such as neuronal cell death and tumor-induced angiogenesis. In conclusion, we demonstrate that DEXA inhibits glioma cell growth in a concentration and species-dependent manner. Further, DEXA executes neuroprotective effects in brains and reduces tumor-induced angiogenesis. Thus, our investigations reveal that DEXA acts pleiotropically and impacts tumor growth, tumor vasculature and tumor-associated brain damage.

Published
2014
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28. The Acidic Brain—Glycolytic Switch in the Microenvironment of Malignant Glioma

Author

Dominik Groos, Anna Maria Reuss, Michael Buchfelder, and Nicolai E. Savaskan

Subjects
Angiogenic Switch, QH301-705.5, Angiogenesis, MCT4, Review, MCT1, Catalysis, Inorganic Chemistry, angiogenesis, Downregulation and upregulation, glioma, Glioma, medicine, HIF, Animals, Humans, tumor microenvironment, Lactic Acid, ddc:610, Biology (General), Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Transcription factor, Spectroscopy, Carbonic Anhydrases, Brain Chemistry, acidic, lactate, Tumor microenvironment, Neovascularization, Pathologic, Brain Neoplasms, Chemistry, Organic Chemistry, Brain, General Medicine, Hydrogen-Ion Concentration, medicine.disease, Computer Science Applications, Anaerobic glycolysis, Cancer cell, Cancer research, glycolytic, Glycolysis, carbonic anhydrase (CA)IX
Abstract

Malignant glioma represents a fatal disease with a poor prognosis and development of resistance mechanisms against conventional therapeutic approaches. The distinct tumor zones of this heterogeneous neoplasm develop their own microenvironment, in which subpopulations of cancer cells communicate. Adaptation to hypoxia in the center of the expanding tumor mass leads to the glycolytic and angiogenic switch, accompanied by upregulation of different glycolytic enzymes, transporters, and other metabolites. These processes render the tumor microenvironment more acidic, remodel the extracellular matrix, and create energy gradients for the metabolic communication between different cancer cells in distinct tumor zones. Escape mechanisms from hypoxia-induced cell death and energy deprivation are the result. The functional consequences are more aggressive and malignant behavior with enhanced proliferation and survival, migration and invasiveness, and the induction of angiogenesis. In this review, we go from the biochemical principles of aerobic and anaerobic glycolysis over the glycolytic switch, regulated by the key transcription factor hypoxia-inducible factor (HIF)-1α, to other important metabolic players like the monocarboxylate transporters (MCTs)1 and 4. We discuss the metabolic symbiosis model via lactate shuttling in the acidic tumor microenvironment and highlight the functional consequences of the glycolytic switch on glioma malignancy. Furthermore, we illustrate regulation by micro ribonucleic acids (miRNAs) and the connection between isocitrate dehydrogenase (IDH) mutation status and glycolytic metabolism. Finally, we give an outlook about the diagnostic and therapeutic implications of the glycolytic switch and the relation to tumor immunity in malignant glioma.

Published
2021

32. Digital Governance: How Blockchain Technologies Revolutionize the Governance of Interorganizational Relationships

Author

Hanisch, Marvin, Theodosiadis, Vasileios, Teixeira, Filipe, Baalmans, Bas S., Broekhuizen, Thijs L. J., and Fabian, Nicolai E.

Subjects
blockchain, practitioner, digital governance
Abstract

Digital technologies are changing the business world at a rapid pace, bringing new challenges and opportunities for companies. This is especially true for blockchain technologies, which are increasingly being used to manage interorganizational transactions. Blockchains are distributed ledger technologies where data is replicated, shared, and synchronized over a network of computers without central servers. The main advantages of blockchains over standard contracts are that they are particularly secure, easily scalable, and comparatively inexpensive. At the same time, blockchains also present managers with a number of challenges in terms of network participation rules, control mechanisms, technology choices, and legal affairs. In this book chapter, we discuss these aspects and provide practical guidance for decision-makers. This discussion makes it easier for managers to determine whether and under what conditions blockchains offer an advantage for their business.

Published
2021

33. Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

Author

Albano, D., Bertagna, F., Alongi, P., Baldari, S., Baldoncini, A., Bartolomei, M., Boccaletto, F., Boero, M., Borsatti, E., Bruno, A., Burroni, L., Capoccetti, F., Castellani, M., Cervino, A. R., Chierichetti, Franca, Ciarmiello, A., Corso, A., Cuocolo, A., De Rimini, M. L., Deandreis, D., Dottorini, M. E., Esposito, Francesca, Farsad, Mohsen, Gasparini, M., Grana, C. M., Gregianin, M., Guerra, L., Loreti, F., Lupi, Alessandro, Martino, G., Milan, E., Modoni, S., Morbelli, S., Muni, A., Nicolai, E., Palumbo, B., Papa, S., Papaleo, A., Pellerito, R., Poti, C., Romano, P., Rossetti, Chiara, Rossini, Paolo Maria, Rubini, G., Ruffini, L., Sacchetti, G., Savelli, Giordano, Schiavariello, Saverio, Sciagra, R., Sciuto, R., Seregni, E., Sestini, S., Sicolo, M., Spanu, A., Storto, G., Balducci, M. T., Trifiro, G., Versari, A., Vignati, A., Volterrani, D., Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, A., Evangelista, L., Maroldi, R., Schillaci, O., Giubbini, R., Bonacina, M., Laudicella, R., Spallino, M., Palucci, A., Cuzzocrea, M., Donner, M., Maurea, S., Ceci, F., Dei Rossi, F., Tranfaglia, B., Sartorello, A., Gandolfo, P., Buschiazzo, A., Scarale, A., Kirienko, M., Merenda, N., Nappi, A. G., Durmo, R., Vellani, C., Ceriani, V., Chierichetti F., Esposito F., Farsad M., Lupi A., Rossetti C., Rossini P. (ORCID:0000-0003-2665-534X), Savelli G., Schiavariello S., Calcagni M. L. (ORCID:0000-0002-0805-8245), Marzola M. C., Albano, D., Bertagna, F., Alongi, P., Baldari, S., Baldoncini, A., Bartolomei, M., Boccaletto, F., Boero, M., Borsatti, E., Bruno, A., Burroni, L., Capoccetti, F., Castellani, M., Cervino, A. R., Chierichetti, Franca, Ciarmiello, A., Corso, A., Cuocolo, A., De Rimini, M. L., Deandreis, D., Dottorini, M. E., Esposito, Francesca, Farsad, Mohsen, Gasparini, M., Grana, C. M., Gregianin, M., Guerra, L., Loreti, F., Lupi, Alessandro, Martino, G., Milan, E., Modoni, S., Morbelli, S., Muni, A., Nicolai, E., Palumbo, B., Papa, S., Papaleo, A., Pellerito, R., Poti, C., Romano, P., Rossetti, Chiara, Rossini, Paolo Maria, Rubini, G., Ruffini, L., Sacchetti, G., Savelli, Giordano, Schiavariello, Saverio, Sciagra, R., Sciuto, R., Seregni, E., Sestini, S., Sicolo, M., Spanu, A., Storto, G., Balducci, M. T., Trifiro, G., Versari, A., Vignati, A., Volterrani, D., Calcagni, Maria Lucia, Marzola, Maria Cristina, Garufo, A., Evangelista, L., Maroldi, R., Schillaci, O., Giubbini, R., Bonacina, M., Laudicella, R., Spallino, M., Palucci, A., Cuzzocrea, M., Donner, M., Maurea, S., Ceci, F., Dei Rossi, F., Tranfaglia, B., Sartorello, A., Gandolfo, P., Buschiazzo, A., Scarale, A., Kirienko, M., Merenda, N., Nappi, A. G., Durmo, R., Vellani, C., Ceriani, V., Chierichetti F., Esposito F., Farsad M., Lupi A., Rossetti C., Rossini P. (ORCID:0000-0003-2665-534X), Savelli G., Schiavariello S., Calcagni M. L. (ORCID:0000-0002-0805-8245), and Marzola M. C.

Abstract

Purpose: To assess the presence and pattern of incidental interstitial lung alterations suspicious of COVID-19 on fluorine-18-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) ([18F]FDG PET/CT) in asymptomatic oncological patients during the period of active COVID-19 in a country with high prevalence of the virus. Methods: This is a multi-center retrospective observational study involving 59 Italian centers. We retrospectively reviewed the prevalence of interstitial pneumonia detected during the COVID period (between March 16 and 27, 2020) and compared to a pre-COVID period (January–February 2020) and a control time (in 2019). The diagnosis of interstitial pneumonia was done considering lung alterations of CT of PET. Results: Overall, [18F]FDG PET/CT was performed on 4008 patients in the COVID period, 19,267 in the pre-COVID period, and 5513 in the control period. The rate of interstitial pneumonia suspicious for COVID-19 was significantly higher during the COVID period (7.1%) compared with that found in the pre-COVID (5.35%) and control periods (5.15%) (p < 0.001). Instead, no significant difference among pre-COVID and control periods was present. The prevalence of interstitial pneumonia detected at PET/CT was directly associated with geographic virus diffusion, with the higher rate in Northern Italy. Among 284 interstitial pneumonia detected during COVID period, 169 (59%) were FDG-avid (average SUVmax of 4.1). Conclusions: A significant increase of interstitial pneumonia incidentally detected with [18F]FDG PET/CT has been demonstrated during the COVID-19 pandemic. A majority of interstitial pneumonia were FDG-avid. Our results underlined the importance of paying attention to incidental CT findings of pneumonia detected at PET/CT, and these reports might help to recognize early COVID-19 cases guiding the subsequent management.

Published
2021

40. Risk-related 18F-FDG PET/CT and new diagnostic strategies in patients with solitary pulmonary nodule: the ITALIAN multicenter trial

Author

Spadafora, M, Pace, L, Evangelista, L, Mansi, L, Del Prete, F, Saladini, G, Miletto, P, Fanti, S, Del Vecchio, S, Guerra, L, Pepe, G, Peluso, G, Nicolai, E, Storto, G, Ferdeghini, M, Giordano, A, Farsad, M, Schillaci, O, Gridelli, C, Cuocolo, A, Spadafora M., Pace L., Evangelista L., Mansi L., Del Prete F., Saladini G., Miletto P., Fanti S., Del Vecchio S., Guerra L., Pepe G., Peluso G., Nicolai E., Storto G., Ferdeghini M., Giordano A., Farsad M., Schillaci O., Gridelli C., Cuocolo A., Spadafora, M, Pace, L, Evangelista, L, Mansi, L, Del Prete, F, Saladini, G, Miletto, P, Fanti, S, Del Vecchio, S, Guerra, L, Pepe, G, Peluso, G, Nicolai, E, Storto, G, Ferdeghini, M, Giordano, A, Farsad, M, Schillaci, O, Gridelli, C, Cuocolo, A, Spadafora M., Pace L., Evangelista L., Mansi L., Del Prete F., Saladini G., Miletto P., Fanti S., Del Vecchio S., Guerra L., Pepe G., Peluso G., Nicolai E., Storto G., Ferdeghini M., Giordano A., Farsad M., Schillaci O., Gridelli C., and Cuocolo A.

Abstract

Purpose: Diagnosis of solitary pulmonary nodule (SPN) is an important public health issue and 18F-FDG PET/CT has proven to be more effective than CT alone. Pre-test risk stratification and clinical presentation of SPN could affect the diagnostic strategy. A relevant issue is whether thoracic segmental (s)-PET/CT could be implemented in patients with SPN. This retrospective multicenter study compared the results of FDG whole-body (wb)-PET/CT to those of s-PET/CT. Methods: 18F-FDG PET/CT of 502 patients, stratified for pre-test cancer risk, were retrospectively analyzed. The thoracic part of wb-PET/CT, considered s-PET/CT, was compared to wb-PET/CT. Clinical and PET/CT variables were investigated for SPN characterization as well as for identification of patients in whom s-PET/CT could be performed. Histopathology or follow-up data were used as a reference. Results: In the study population, 36% had malignant, 35% benign, and 29% indeterminate SPN. 18F-FDG uptake indicative of thoracic and extra-thoracic lesions was detectable in 13% and 3% of the patients. All patients with extra-thoracic metastases (n = 13) had thoracic lymph node involvement and highest 18F-FDG uptake at level of SPN (negative predictive value 100%). Compared to wb-PET/CT, s-PET/CT could save about 2/3 of 18F-FDG dose, radiation exposure or scan-time, without affecting the clinical impact of PET/CT. Conclusion: Pre-test probability of malignancy can guide the diagnostic strategy of 18FDG-PET/CT in patients with SPN. In subjects with low-intermediate pretest probability s-PET/CT imaging might be planned in advance, while in those at high risk and with thoracic lymph node involvement a wb-PET/CT is necessary

Published
2018

41. Small interfering RNA--mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

Author

Savaskan, Nicolai E., Heckel, Alexandra, Hahnen, Eric, Engelhorn, Tobias, Doerfler, Arnd, Ganslandt, Oliver, Nimsky, Christopher, Buchfelder, Michael, and Eyupoglu, Ilker Y.

Subjects
Brain tumors -- Complications and side effects, Brain tumors -- Diagnosis, Brain tumors -- Care and treatment, Brain tumors -- Research, Glutamate -- Health aspects, Glutamate -- Research, Cerebral edema -- Risk factors, Cerebral edema -- Control, Cerebral edema -- Research, Nervous system -- Degeneration, Nervous system -- Risk factors, Nervous system -- Control, Nervous system -- Research
Abstract

Neurodegeneration and brain edema are hallmarks of human malignant brain tumors. Here we show that genetic or pharmacological inhibition of the glutamate transporter xCT ([X.sub.bar.c] system, encoded by SLC7a11) in vivo leads to abrogated neurodegeneration, attenuated perifocal edema and prolonged survival. These results show a crucial role for xCT in glioma-induced neurodegeneration and brain edema, corroborating the concept that edema formation may be in part a consequence of peritumoral cell death., Malignant brain tumors represent one of the most aggressive neoplasias, and they still have a poor prognosis despite aggressive cytotoxic therapies. In addition to uncontrolled proliferation and diffuse tissue invasion, [...]

Published
2008

47. Abstracts

Author

Nicolai, E., Cuocolo, A., Acampa, W., Varrone, A., Pace, A., and Salvatore, M.

Published
1999
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49. T02.02.24 THE EFFECTS OF ORAL NUTRITIONAL SUPPLEMENTS ON THE NUTRITIONAL STATUS OF A GROUP OF MALNOURISHED OUT-PATIENTS WITH MULTIPLE COMORBIDITIES

Author

Lanzi, P., primary, Noè, D., additional, Nicolai, E., additional, Spiti, R., additional, Tagliabue, V., additional, Zanoni, M.C., additional, Raschioni, E., additional, Ferrari, E.G., additional, Marini, M., additional, Combi, S., additional, Masi, F., additional, Barsi, M., additional, and Soncini, M., additional

Published
2020
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