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This randomized clinical trial was carried out to compare post cementation sensitivity in vital abutments of metal-ceramic fixed partial dentures using glass ionomer luting cement and resin based luting cement. It analyzed the results of 182 patients whose records were completed during study duration of 09 months at Department of Prosthodontics, AFID, Rawalpindi. Cold sensitivity tests were used to compare post cementation sensitivity in vital abutments of fixed partial dentures using resin based luting cement and glass ionomer luting cement. Sensitivity was assessed on a modified visual analogue scale of 0-10; scores of 1-4 signified mild sensitivity, 5-7 moderate sensitivity, 8-10 severe sensitivity and score of 0 signified no response. The sensitivity results were checked at base line, at 1 week, at 1 month, at 3 months. Data of 182 subjects of mean age 26.15±3.15 was evaluated. Chi-sqaure test was used to see the association of type of cement used and the postoperative sensitivity. The p values for the chi square test were insignificant P- values (P>0.05) at all appointments in abutments of fixed partial denture with either resin based or glass ionomer luting cement. The study showed that there is no significant difference between resin based luting cements and glass ionomer luting cements in terms of post cementation sensitivity in vital teeth. [ABSTRACT FROM AUTHOR]