Search

In this context, we aimed to investigate the effects of varying levels of Fumaric Acid (Fu), Malic Acid (Ma), Formic Acid (Fo), and their combinations on in-vitro degradability parameters, organic matter digestibility (OMD), metabolizable energy (ME) and net energy lactation (NEL) of alfalfa (Medicago polymorphia), white clover (Trifolium repens) and hairy vetch (Vicia villosa). Obtained data were analyzed as a completely randomized 3×8 factorial design, with GLM using SAS 9.4. The effects of legume forages and their interacion with organic acid were significant on ME, NEL and OMD values (p

OHEJP SimEx Handbook for National Exercise Leaders (NEL) and Local Exercise Leaders (LEL)

Doelstelling: Deze studie wil de betrouwbaarheid en validiteit van de Eigen-Wijsheidschaal (EWS) van de Nederlandse Empowerment Lijst (NEL) onderzoeken voor het meten van identiteit en hoop/zingeving bij de volgende christelijke patiëntengroepen: bevindelijk-gereformeerd, evangelisch en anders-protestanten. Daarbij wordt onderzocht in hoeverre het ervaren van de sturing door God op gespannen voet staat met het vertrouwen in eigen regie. Methode: Aan de hand van de COSMIN-criteria zijn de EWS-data van christelijke patiënten met angst- en depressiestoornissen (n=277) met betrouwbaarheidsanalyses, correlatieanalyses en MANCOVA geanalyseerd op de volgende aspecten: structurele validiteit, interne consistentie, convergente validiteit, divergente validiteit en interculturele validiteit. Resultaten: De interne consistentie is goed en de convergente en divergente validiteit zijn bevredigend. De EWS gedraagt zich bij de onderzochte christelijke doelgroepen op een vergelijkbare manier, zonder duidelijke verschillen tussen de groepen. Conclusie: De EWS is een betrouwbaar en valide instrument om de hoop/zingeving en identiteit te meten bij een (orthodox-)christelijke patiëntengroep. Implicaties voor de praktijk: De EWS geeft een indicatie in hoeverre patiënten perspectief en veerkracht ervaren. De antwoorden kunnen gebruikt worden als onderdeel van gesprekken in een ontwikkelrichting naar herstel.

The aim of the research was to compare the productivity and quality of several forage grasses in the climate conditions of south-eastern Europe. The research was conducted during 2012 and 2013, in the south-western part of the Pannonian basin (vicinity of Osijek, Croatia). The experiment included 5 grass species: Italian ryegrass (Lolium multiflorum), cocksfoot (Dactylis glomerata), hybrid ryegrass (Lolium x boucheanum), perennial ryegrass (Lolium perenne) and timothy (Phleum pratense) cut three times per year, i.e. 6 cuttings in total for two years. The results have shown that there were significant statistical differences for all investigated traits between the species, years and their interaction at the P˂0.05 levels. In average, the highest dry matter yield was achieved during the first year of using (10.4 and 9.1 t*ha-1). In average two years of using, the highest yields of dry matter had Italian ryegrass and cocksfoot. Quality results showed that the cocksfoot was the least digestible because it contained over 700 g*kg-1 of NDF and 450 g*kg-1 of ADF, unlike the perennial ryegrass which had 559 and 327 g*kg-1 of NDF and ADF. The final results showed the productivity per hectare where the most energy-producing species of Italian ryegrass with the possible production of 19, 739 liters of milk with 4% milk fat. On the base protein productivity, the most prominent was the cocksfoot which could produce 11, 878 liters of milk from 713 kg proteins in one year. The results show that none of the tested grasses had a balanced relationship between protein and energy.

Doelstelling: Deze studie wil de betrouwbaarheid en validiteit van de Eigen-Wijsheidschaal (EWS) van de Nederlandse Empowerment Lijst (NEL) onderzoeken voor het meten van identiteit en hoop/zingeving bij de volgende christelijke patiëntengroepen: bevindelijk-gereformeerd, evangelisch en anders-protestanten. Daarbij wordt onderzocht in hoeverre het ervaren van de sturing door God op gespannen voet staat met het vertrouwen in eigen regie. Methode: Aan de hand van de COSMIN-criteria zijn de EWS-data van christelijke patiënten met angst- en depressiestoornissen (n=277) met betrouwbaarheidsanalyses, correlatieanalyses en MANCOVA geanalyseerd op de volgende aspecten: structurele validiteit, interne consistentie, convergente validiteit, divergente validiteit en interculturele validiteit. Resultaten: De interne consistentie is goed en de convergente en divergente validiteit zijn bevredigend. De EWS gedraagt zich bij de onderzochte christelijke doelgroepen op een vergelijkbare manier, zonder duidelijke verschillen tussen de groepen. Conclusie: De EWS is een betrouwbaar en valide instrument om de hoop/zingeving en identiteit te meten bij een (orthodox-)christelijke patiëntengroep. Implicaties voor de praktijk: De EWS geeft een indicatie in hoeverre patiënten perspectief en veerkracht ervaren. De antwoorden kunnen gebruikt worden als onderdeel van gesprekken in een ontwikkelrichting naar herstel.

The metallopeptidases thimet oligopeptidase (THOP, EC 3.4.24.25) and neurolysin (NEL, EC 3.4.24.26) are enzymes that belong to the zinc endopeptidase M13 family. Numerous studies suggest that these peptidases participate in the processing of bioactive peptides such as angiotensins and bradykinin. Efforts have been conducted to develop biotechnological tools to make possible the use of both proteases to regulate blood pressure in mice, mainly limited by the low plasmatic stability of the enzymes. In the present study, it was investigated the use of nanotechnology as an efficient strategy for to circumvent the low stability of the proteases. Recombinant THOP and NEL were immobilized in gold nanoparticles (GNPs) synthesized in situ using HEPES and the enzymes as reducing and stabilizing agents. The formation of rTHOP-GNP and rNEL-GNP was characterized by the surface plasmon resonance band, zeta potential and atomic force microscopy. The gain of structural stability and activity of rTHOP and rNEL immobilized on GNPs was demonstrated by assays using fluorogenic substrates. The enzymes were also efficiently immobilized on GNPs fabricated with sodium borohydride. The efficient immobilization of the oligopeptidases in gold nanoparticles with gain of stability may facilitate the use of the enzymes in therapies related to pressure regulation and stroke, and as a tool for studying the physiological and pathological roles of both proteases.

This paper presents an overview of the first edition of HIPE (Identifying Historical People, Places and other Entities), a pioneering shared task dedicated to the evaluation of named entity processing on historical newspapers in French, German and English. Since its introduction some twenty years ago, named entity (NE) processing has become an essential component of virtually any text mining application and has undergone major changes. Recently, two main trends characterise its developments: the adoption of deep learning architectures and the consideration of textual material originating from historical and cultural heritage collections. While the former opens up new opportunities, the latter introduces new challenges with heterogeneous, historical and noisy inputs. In this context, the objective of HIPE, run as part of the CLEF 2020 conference, is threefold: strengthening the robustness of existing approaches on non-standard inputs, enabling performance comparison of NE processing on historical texts, and, in the long run, fostering efficient semantic indexing of historical documents. Tasks, corpora, and results of 13 participating teams are presented.

Geographical data can be obtained by converting place names from free-format text into geographical coordinates. The ability to geo-locate events in textual reports represents a valuable source of information in many real-world applications such as emergency responses, real-time social media geographical event analysis, understanding location instructions in auto-response systems and more. However, geoparsing is still widely regarded as a challenge because of domain language diversity, place name ambiguity, metonymic language and limited leveraging of context as we show in our analysis. Results to date, whilst promising, are on laboratory data and unlike in wider NLP are often not cross-compared. In this study, we evaluate and analyse the performance of a number of leading geoparsers on a number of corpora and highlight the challenges in detail. We also publish an automatically geotagged Wikipedia corpus to alleviate the dearth of (open source) corpora in this domain.

The aim of the research was to compare the productivity and quality of several forage grasses in the climate conditions of south-eastern Europe. The research was conducted during 2012 and 2013, in the south-western part of the Pannonian basin (vicinity of Osijek, Croatia). The experiment included 5 grass species: Italian ryegrass (Lolium multiflorum), cocksfoot (Dactylis glomerata), hybrid ryegrass (Lolium x boucheanum), perennial ryegrass (Lolium perenne) and timothy (Phleum pratense) cut three times per year, i.e. 6 cuttings in total for two years. The results have shown that there were significant statistical differences for all investigated traits between the years of the species and their interaction at the P˂0.05 levels. In average, the highest dry matter yield was achieved during the first year of usage (10.4 and 9.1 t/ha). The average usage of two years, the highest yields of dry matter had Italian ryegrass and cocksfoot. Quality results showed that the cocksfoot was the least digestible because it contained over 700 g/kg of neutral detergent fiber (NDF) and 450 g/kg of acid detergent fiber (ADF), unlike the perennial ryegrass which had 559 and 327 g/kg of NDF and ADF. Energetically most productive was Italian ryegrass with a production potential of 19,739 liters of milk and with milk fat of 4%. On the protein productivity base, the most prominent was the cocksfoot which could produce 11,878 liters of milk from 713 kg proteins in one year. The results show that none of the tested grasses had a balanced relationship between protein and energy., Istraživanje je imalo za cilj komparirati produktivnost i kvalitetu nekoliko vrsta trava u klimatskim uvjetima jugoistočne Europe. Istraživanje je provedeno tijekom 2012. i 2013. godine u jugozapadnom dijelu Panonske nizine (okolica Osijeka, Hrvatska). U pokusu su istraživani klupčasta oštrica, mačji repak, talijanski, hibridni i engleski ljulj u 4 repeticije. Provedene su 3 košnje po godini ili 6 otkosa za svaku vrstu tijekom pokusa. Rezultati su pokazali da postoje značajne statističke razlike za sva istraživana svojstva između vrsta, godina i njihove interakcije na nivou P˂0,05. U prosjeku, najveći prinos suhe tvari ostvaren je tijekom prve godine uporabe (10,4 i 9,1 t/ha). U prosjeku za dvije godine korištenja, najveći prinosi suhe tvari imali su talijanski ljulj i klupčasta oštrica. Rezultati kvalitete pokazali su da je klupčasta oštrica bila najmanje probavljiva, jer je sadržavala preko 700 g/kg vlakna topiva u neutralnom detrđentu (NDF) i 450 g/kg vlakna topiva u kiselom detrđentu (ADF), za razliku od engleskog ljulja koji je imao 559 i 327 g/kg NDF i ADF. Energetski najproduktivniji je bio talijanski ljulj sa proizvodnim potencijalom od 19.739 litara mlijeka uz mliječnu mast od 4%. Na osnovu proteina najprinosnija je bila klupčasta oštrica, koja može proizvesti 11.878 litara mlijeka iz 713 kg proteina u jednoj godini. Rezultati pokazuju da niti jedna testirana trava nije imala balansiran odnos proteina i energije.

In this report a risk assessment or evaluation system for agricultural pesticides is presented, which estimates the hazards for man and environment resulting from the use of these pesticides. The evaluation system has also been placed within the context of the Uniform System for the Evaluation of Substances (USES). The evaluation system for pesticides (ESPE) is divided in three parts: 1) emission of the pesticide ; 2) distribution over and within the different environmental compartments and calculation of exposure concentrations of organisms to the pesticide ; 3) hazard assessment. The mathematical descriptions of various parts of the assessment system for agricultural pesticides are presented in this report. In the first part, an estimation is made of the percentages of emission of the used dosage for the several environmental compartments. In the distribution part, the different transport and translation processes are assessed. This leads to Predicted (Initial) Environmental Concentrations (P(I)ECs) for the different environmental compartments and to transport fluxes between these compartments. In the third part, hazard assessment is carried out by comparing P(I)ECs with chronic or acute toxicity data (e.g. NOECs,L(E)C50s) for several non-target organisms. For the environmental hazard assessment decision trees, developed by the Support Group Environment of the CTB, are used. For human beings, in this system only consumers, no decision trees have been developed. Hazard assessment for indirect exposure is performed by comparing the total daily intake with the No Observed Adverse Effect Level (NOAEL).

Betreft Engelse vertaling van 710401023

Daphnia magna is used as a model organism to study the consequences of the impact of mutagenic chemicals to natural populations. Adult daphnids were exposed to a mutagenic test compound to test whether their offspring showed effects of induced mutations at exposure levels lower than the No Observed Effect Concentration for growth and reproduction. Life-history parameters were used as test parameters. A concentration-related toxic effect to reproduction could be measured reproducibly in the exposed adult daphnids. However, no indication of a mutagenic effect could be detected in their offspring. This may have been due to the inadequateness of the system to detect induced genetic change.

Bij dit rapport behoort een Appendix onder hetzelfde nummer getiteld: Appendix to integrated criteria document zinc. ecotoxicity. AU: Janus JAvoor de Engelse editie zie 710401028

The aim of the bachelor thesis was to find out in a one-year small land parcel vegetation experiment the yield reaction of maize (Zea mays L.) varieties LG 30.220 and LG 31.233 on split nitrogen application. In addition to the yield, the fertilizer effect on the quality of silage maize was investigated. The experiment was based on the experimental station in Vatín, nitrogen was applied in 4 variants: var. 1 - without fertilizing, var. 2 - 150 kg.ha-1 when sowing, var. 3 - 50 kg.ha-1 when sowing and 100 kg.ha-1 in phase V8, var. 4 - 100 kg.ha-1 for sowing and 50 kg.ha-1 for V8 phase. Inorganic plant analyzes characterizing the influence of fertilization on maize growth and development were made from plant withdrawals on 6 June 2016 and 17 July 2016. After harvest following indicators were evaluated such as green harvest yield, dry substance yield, dry matter yield, NEL value and organic matter digestibility. Hybrid factors and nitrogen fertilization were positively reflected in the yield of corn green. The probative effect of split nitrogen application was demonstrated only on dry mass production of hybrid LG 30.220. The dry matter of maize harvested, the digestibility of organic matter and the net energy for lactation did not differ significantly among the hybrids studied. From the monitored qualitative parameters, only the digestibility of the organic matter was significantly affected by the split nitrogen application.

The Navy’s eLearning (NeL) computer-based learning system relies on a Learning Management System (LMS) for content delivery and tracking learning information. One major obstacle with NeL’s current LMS implementation is that tracking of learning can only be done while a user is on a desktop computer using an Internet browser to connect to the LMS SOFtware. However, not all learning takes place within an Internet browser on a desktop computer. The Experience-API (xAPI), also known as Tin Can API and SCORM 2.0, is a standard maintained by Advanced Distributed Learning (ADL) that decouples the tracking of learning information from the content delivery. Any piece of SOFtware implementing the xAPI standard running on any networked device can track learning activity and store that data inside of a Learning Record Store (LRS). A prototype system was developed in a virtual environment to showcase the use of the xAPI/LRS to track quiz data, and the quiz data could then be synced from the LRS to the LMS. The prototype showed that xAPI, along with its LRS, can overcome the NeL’s AtlasPro LMS limitation of only tracking learning from a user’s desktop computer using an Internet browser. http://archive.org/details/nextgennavyelear1094544616 Civilian, Department of Defence, Defense Manpower Data Center Approved for public release; distribution is unlimited.

In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg benzylbutylphthalate (BBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH)) have been determined in liver homogenates. No effect has been observed on the liver weight. The body weight showed a significant decrease as the highest dose level. PCO and CAT showed no effect up to 600 mg BBP/kg diet. LAH was more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet, corresponding with 19.1 mg BBP/kg b.w./day. ECH appeared to be the most sensitive parameter with an effect in all dose levels used. Therefore, no overall no-observed effect level can be defined in this experiment.

In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg diethylphthalate (DEP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effects have been observed on the liver and body weights. PCO and LAH showed no effects up to 2000 and 600 mg DEP/kg diet, respectively. ECH was more sensitive with a dose-without-effect (DWE) of 200 mg/kg diet. Cat was the most sensitive parameter with an effect in all dose groups. Although CAT turned out the most sensitive parameter, this enzyme was not considered in the establishment of an overall no-observed-effect-level for peroxisome proliferation since it is not specific for peroxisome proliferation. The second most sensitive parameter was the ECH activity. Therefore an overall no-observed-effect-level for peroxisome proliferation of 200 mg DEP/kg diet was established corresponding to 19 mg DEP/kg b.w./day.

In a study in which male rats have been exposed to 0, 200, 600, 2000, 6000 and 20000 mg di(2-ethylhexyl)adipate (DEHA)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effect has been observed on the liver weight. The highest dose group showed a significant decrease in the body weight. PCO, CAT and LAH showed no effect up to 2000 mg DEHA/kg diet. ECH, an enzyme involved in the beta-oxidation, was more sensitive with a dose-without-effect (DWE) of 200 mg DEHA/kg diet. Therefore an overall no-observed-effect-level of 200 mg DEHA/KG diet was defined equal to 20.1 mg DEHA/kg b.w.day.

In a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg dibutylphthalate (DBP)/kg diet for 2 weeks, body weight and liver weight and a number of enzyme parameters which are related with peroxisome proliferation (palmitoyl coenzyme-A oxidase (PCO, enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effect has been observed on the body and liver weight. For PCO a dose-without-effect was determined of 600 mg BBP/kg diet. The three other enzymes, ECH, CAT and LAH were more sensitive with a dose-without-effect (DWE) of 200 mg BBP/kg diet. Therefore, an overall no-observed-effect-level of 200 mg BBP/kg diet was established in this experiment, corresponding with 19.9 mg BBP/kg b.w./day.

In a study in which male rats have been exposed to 0, 20, 60, 200, 600 and 2000 mg di(cyclohexyl)phthalate (DCHP)/kg diet for 2 weeks, body weight and liver weight and a number of enzym parameters which are related with peroxisome proliferation palmitoyl coenzyme-A oxidase (PCO), enoyl coenzyme-A hydratase (ECH), carnitine acetyl transferase (CAT) and lauric acid hydroxylase (LAH) have been determined in liver homogenates. No effects have been observed on the liver and body weights. CAT showed no effect up to 600 mg DCHP/kg diet. PCO and LAH were more sensitive with a dose-without-effect (DWE) of 200 mg DCHP/kg diet. ECH, an enzyme involved in the beta-oxidation, appeared to be the most sensitive parameter with a dose-without-effect of 60 mg DCHP/kg diet. Therefore an overall no-observed-effect-level of 60 mg DCHP/kg diet was defined corresponding to 5.8 mg DCHP/kg b.w./day.

dit rapport is de Engelse versie van rapport nummer 710401029

dit rapport is de Engelse versie van rapport nummer 710401029

Teneinde een "no effect level" van glycyrrhizine vast te stellen, werd een dubbelblind, gerandomiseerd, gecontroleerd onderzoek uitgevoerd bij 39 gezonde vrouwelijke vrijwilligers. Gedurende 8 weken werd glycyrrhizine in een dosis van 0, 1, 2 of 4 mg per kg lichaamsgewicht ingenomen. De doseringen en de keus voor vrouwelijke deelnemers waren gebaseerd op een voorafgaand pilot onderzoek. De volgende parameters werden bestudeerd: gewicht, bloeddruk, electrolyten concentratie in plasma, 24-uurs excretie van electrolyten in urine, plasma renine activiteit, plasma aldosteron concentratie, atriaal natriuretisch peptide concentratie en de concentratie van glycyrrhetinezuur in plasma. De deelnemers hielden een klachtenlogboek en eetdagboekjes bij. Alleen in de hoogste doseringsgroep van 4 mg glycyrrhizine per kg lichaamsgewicht werden effecten waargenomen. Deze betroffen volume expansie enerzijds en veranderingen in plasma electrolyten anderzijds. De volume expansie tijdens glycyrrhizine-inname kwam tot uiting in suppressie van het renine-angiotensine-aldosteron systeem en toename van gewicht. Tevens daalde de atriaal natriuretisch peptide-concentratie na het staken van de glycyrrhizine-inname. De electrolytveranderingen betroffen daling van plasma kalium en stijging van plasma bicarbonaat-concentratie tijdens de glycyrrhizine-inname. Op grond van deze gegevens kan een "no effect level" van 2 mg glycyrrhizine per kg lichaamsgewicht per dag worden afgeleid.