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2,167 results on '"NEGRO, FRANCESCO"'

1. Bisogni linguistici specifici e comprensione del testo narrativo

Author

Negro, Francesco

Subjects
BiLS. Ditactics. Dyslexia. Italian literature. Reading comprehension, Language. Linguistic theory. Comparative grammar, P101-410
Abstract

The purpose of this study is to analyse difficulties and special needs of Language Specific Needs students (BiLS, Bisogni Linguistici Specifici) in the field of comprehension of a narrative text and, specifically, in the study of fiction. This paper summarises the theories on which this study is built and, in a second stage, describes the particular case that brought at the compilation and practice of specific teaching method on the narrative category of the character. Our goal is to verify the efficacy and strength of this teaching method built specifically for BiLS students to facilitates the reading approach of a narrative text book, allowing the student to get closer with reading and consulting a narrative text book. The results of the case study are particularly satisfying, specifically regarding the positive approach of the student with the text analysis and fiction learning.

Published
2017
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3. High-density magnetomyography is superior to high-density surface electromyography for motor unit decomposition: a simulation study

Author

Klotz, Thomas, Lehmann, Lena, Negro, Francesco, and Röhrle, Oliver

Subjects
Quantitative Biology - Tissues and Organs, Quantitative Biology - Cell Behavior, Quantitative Biology - Neurons and Cognition, Quantitative Biology - Quantitative Methods
Abstract

Objective: Studying motor units (MUs) is essential for understanding motor control, the detection of neuromuscular disorders and the control of human-machine interfaces. Individual motor unit firings are currently identified in vivo by decomposing electromyographic (EMG) signals. Due to our body's properties and anatomy, individual motor units can only be separated to a limited extent with surface EMG. Unlike electrical signals, magnetic fields do not interact with human tissues. This physical property and the emerging technology of quantum sensors make magnetomyography (MMG) a highly promising methodology. However, the full potential of MMG to study neuromuscular physiology has not yet been explored. Approach: In this work, we perform in silico trials that combine a biophysical model of EMG and MMG with state-of-the-art algorithms for the decomposition of motor units. This allows the prediction of an upper-bound for the motor unit decomposition accuracy. Main results: It is shown that non-invasive high-density MMG data is superior over comparable high-density surface EMG data for the robust identification of the discharge patterns of individual motor units. Decomposing MMG instead of EMG increased the number of identifiable motor units by 76%. Notably, MMG exhibits a less pronounced bias to detect superficial motor units. Significance: The presented simulations provide insights into methods to study the neuromuscular system non-invasively and in vivo that would not be easily feasible by other means. Hence, this study provides guidance for the development of novel biomedical technologies.

Published
2023

8. Proposal of a Multi-parametric Ergonomic Assessment Protocol Integrating Intra-operative Use of Wearable Technology to Evaluate Musculoskeletal Discomfort for Surgeon During Laryngeal Surgery

Author

Sala, Emma, Mazzali, Marco, Paraggio, Emilio, Rossetto, Gianluca, Cassiolas, Giorgio, Scalona, Emilia, Negro, Francesco, De Palma, Giuseppe, Piazza, Cesare, Lopomo, Nicola Francesco, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Duffy, Vincent G., editor, Krömker, Heidi, editor, A. Streitz, Norbert, editor, and Konomi, Shin'ichi, editor

Published
2023
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9. Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study

Author

Razavi-Shearer, Devin, Gamkrelidze, Ivane, Pan, Calvin, Jia, Jidong, Berg, Thomas, Gray, Richard, Lim, Young-Suk, Chen, Chien-Jen, Ocama, Ponsiano, Desalegn, Hailemichael, Abbas, Zaigham, Abdallah, Ayat, Aghemo, Alessio, Ahmadbekova, Sabohat, Ahn, Sang Hoon, Aho, Inka, Akarca, Ulus, Al Masri, Nasser, Alalwan, Abduljaleel, Alavian, Seyed, Al-Busafi, Said, Aleman, Soo, Alfaleh, Faleh, Alghamdi, Abdullah, Al-Hamoudi, Waleed, Aljumah, Abdulrahman, Al-Naamani, Khalid, Al-Rifai, Ahmad, Alserkal, Yousif, Altraif, Ibrahim, Amarsanaa, Jazag, Anderson, Motswedi, Andersson, Monique, Armstrong, Paige, Asselah, Tarik, Athanasakis, Kostas, Baatarkhuu, Oidov, Ben-Ari, Ziv, Bensalem, Aicha, Bessone, Fernando, Biondi, Mia, Bizri, Abdul Rahman, Blach, Sarah, Braga, Wornei, Brandão-Mello, Carlos, Brosgart, Carol, Brown, Kimberly, Brown, Jr, Robert, Bruggmann, Philip, Brunetto, Maurizia, Buti, Maria, Cabezas, Joaquin, Casanovas, Teresa, Chae, Chungman, Chan, Henry Lik Yuen, Cheinquer, Hugo, Chen, Pei-Jer, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura, Coffin, Carla, Contreras, Fernando, Coppola, Nicola, Cornberg, Markus, Cowie, Benjamin, Cramp, Matthew, Craxi, Antonio, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris, Dalgard, Olav, De Knegt, Robert, De Ledinghen, Victor, Dore, Gregory, Drazilova, Sylvia, Duberg, Ann-Sofi, Egeonu, Steve, Elbadri, Mohammed, El-Kassas, Mohamed, El-Sayed, Manal, Estes, Chris, Etzion, Ohad, Farag, Elmobashar, Ferradini, Laurent, Ferreira, Paulo, Flisiak, Robert, Forns, Xavier, Frankova, Sona, Fung, James, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana, Gholam, Pierre, Gish, Robert, Goleij, Pouya, Gottfredsson, Magnus, Grebely, Jason, Gschwantler, Michael, Guingane, Nanelin Alice, Hajarizadeh, Behzad, Hamid, Saeed, Hamoudi, Waseem, Harris, Aaron, Hasan, Irsan, Hatzakis, Angelos, Hellard, Margaret, Hercun, Julian, Hernandez, Javier, Hockicková, Ivana, Hsu, Yao-Chun, Hu, Ching-Chih, Husa, Petr, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jelev, Deian, Jeruma, Agita, Johannessen, Asgeir, Kåberg, Martin, Kaita, Kelly, Kaliaskarova, Kulpash, Kao, Jia-Horng, Kelly-Hanku, Angela, Khamis, Faryal, Khan, Aamir, Kheir, Omer, Khoudri, Ibtissam, Kondili, Loreta, Konysbekova, Aliya, Kristian, Pavol, Kwon, Jisoo, Lagging, Martin, Laleman, Wim, Lampertico, Pietro, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice, Lee, Mei-Hsuan, Liakina, Valentina, Lukšić, Boris, Malekzadeh, Reza, Malu, Abraham, Marinho, Rui, Mendes-Correa, Maria Cássia, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mohamed, Rosmawati, Mokhbat, Jacques, Mooneyhan, Ellen, Moreno, Christophe, Mortgat, Laure, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Naveira, Marcelo, Negro, Francesco, Nersesov, Alexander, Nguyen, Van Thi Thuy, Ning, Qing, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin, Oguche, Stephen, Omuemu, Casimir, Ong, Janus, Opare-Sem, Ohene, Örmeci, Necati, Orrego, Mauricio, Osiowy, Carla, Papatheodoridis, George, Peck-Radosavljevic, Markus, Pessoa, Mário, Pham, Trang, Phillips, Richard, Pimenov, Nikolay, Pincay-Rodríguez, Loreley, Plaseska-Karanfilska, Dijana, Pop, Cora, Poustchi, Hossein, Prabdial-Sing, Nishi, Qureshi, Huma, Ramji, Alnoor, Rautiainen, Henna, Razavi-Shearer, Kathryn, Remak, William, Ribeiro, Sofia, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo, Robalino, Marcia, Roberts, Lewis, Roberts, Stuart, Rodríguez, Manuel, Roulot, Dominique, Rwegasha, John, Ryder, Stephen, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa, Salupere, Riina, Sanai, Faisal, Sanchez-Avila, Juan F, Saraswat, Vivek, Sargsyants, Narina, Sarrazin, Christoph, Sarybayeva, Gulya, Schréter, Ivan, Seguin-Devaux, Carole, Seto, Wai-Kay, Shah, Samir, Sharara, Ala, Sheikh, Mahdi, Shouval, Daniel, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta, Sinn, Dong Hyun, Sonderup, Mark, Sonneveld, Milan, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf, Stedman, Catherine, Sypsa, Vana, Tacke, Frank, Tan, Soek-Siam, Tanaka, Junko, Tergast, Tammo, Terrault, Norah, Thompson, Alexander, Thompson, Peyton, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsang, Tak-Yin, Uzochukwu, Benjamin, Van Welzen, Berend, Vanwolleghem, Thomas, Vince, Adriana, Voeller, Alexis, Waheed, Yasir, Waked, Imam, Wallace, Jack, Wang, Cong, Weis, Nina, Wong, Grace, Wong, Vincent, Wu, Jaw-Ching, Yaghi, Cesar, Yesmembetov, Kakharman, Yip, Terry, Yosry, Ayman, Yu, Ming-Lung, Yuen, Man-Fung, Yurdaydin, Cihan, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie

Published
2023
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10. A global research priority agenda to advance public health responses to fatty liver disease

Author

Lazarus, Jeffrey V., Mark, Henry E., Allen, Alina M., Arab, Juan Pablo, Carrieri, Patrizia, Noureddin, Mazen, Alazawi, William, Alkhouri, Naim, Alqahtani, Saleh A., Arrese, Marco, Bataller, Ramon, Berg, Thomas, Brennan, Paul N., Burra, Patrizia, Castro-Narro, Graciela E., Cortez-Pinto, Helena, Cusi, Kenneth, Dedes, Nikos, Duseja, Ajay, Francque, Sven M., Hagström, Hannes, Huang, Terry T-K., Wajcman, Dana Ivancovsky, Kautz, Achim, Kopka, Christopher J., Krag, Aleksander, Miller, Veronica, Newsome, Philip N., Rinella, Mary E., Romero, Diana, Sarin, Shiv Kumar, Silva, Marcelo, Spearman, C. Wendy, Tsochatzis, Emmanuel A., Valenti, Luca, Villota-Rivas, Marcela, Zelber-Sagi, Shira, Schattenberg, Jörn M., Wong, Vincent Wai-Sun, Younossi, Zobair M., Aberg, Fredrik, Adams, Leon, Al-Naamani, Khalid, Albadawy, Reda M., Alexa, Zinaida, Allison, Michael, Alnaser, Faisal A., Alswat, Khalid, Alvares-da-Silva, Mario Reis, Alvaro, Domenico, Alves-Bezerra, Michele, Andrade, Raul J., Anstee, Quentin M., Awuku, Yaw Asante, Baatarkhuu, Oidov, Baffy, Gyorgy, Bakieva, Shokhista, Bansal, Meena B., Barouki, Robert, Batterham, Rachel L., Behling, Cynthia, Belfort-DeAguiar, Renata, Berzigotti, Annalisa, Betel, Michael, Bianco, Cristiana, Bosi, Emanuele, Boursier, Jerome, Brunt, Elizabeth M., Bugianesi, Elisabetta, Byrne, Christopher J., Cabrera Cabrejos, Maria Cecilia, Caldwell, Stephen, Carr, Rotonya, Castellanos Fernández, Marlen Ivón, Castera, Laurent, Castillo-López, Maria Gabriela, Caussy, Cyrielle, Cerda-Reyes, Eira, Ceriello, Antonio, Chan, Wah- Kheong, Chang, Yoosoo, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chung, Raymond T., Colombo, Massimo, Coppell, Kirsten, Cotrim, Helma P., Craxi, Antonio, Crespo, Javier, Dassanayake, Anuradha, Davidson, Nicholas O., De Knegt, Robert, de Ledinghen, Victor, Demir, Münevver, Desalegn, Hailemichael, Diago, Moises, Dillon, John F., Dimmig, Bruce, Dirac, M. Ashworth, Dirchwolf, Melisa, Dufour, Jean-François, Dvorak, Karel, Ekstedt, Mattias, El-Kassas, Mohamed, Elsanousi, Osama M., Elsharkawy, Ahmed M., Elwakil, Reda, Eskridge, Wayne, Eslam, Mohammed, Esmat, Gamal, Fan, Jian- Gao, Ferraz, Maria Lucia, Flisiak, Robert, Fortin, Davide, Fouad, Yasser, Freidman, Scott L., Fuchs, Michael, Gadano, Adrian, Gastaldelli, Amalia, Geerts, Anja, Geier, Andreas, George, Jacob, Gerber, Lynn H., Ghazinyan, Hasmik, Gheorghe, Liana, Kile, Denise Giangola, Girala, Marcos, Boon Bee, George Goh, Goossens, Nicolas, Graupera, Isabel, Grønbæk, Henning, Hamid, Saeed, Hebditch, Vanessa, Henry, Zachary, Hickman, Ingrid J., Hobbs, L. Ansley, Hocking, Samantha L., Hofmann, Wolf Peter, Idilman, Ramazan, Iruzubieta, Paula, Isaacs, Scott, Isakov, Vasily A., Ismail, Mona H., Jamal, Mohammad H., Jarvis, Helen, Jepsen, Peter, Jornayvaz, François, Sudhamshu, K.C., Kakizaki, Satoru, Karpen, Saul, Kawaguchi, Takumi, Keating, Shelley E., Khader, Yousef, Kim, Seung Up, Kim, Won, Kleiner, David E., Koek, Ger, Joseph Komas, Narcisse Patrice, Kondili, Loreta A., Koot, Bart G., Korenjak, Marko, Kotsiliti, Eleni, Koulla, Yiannoula, Kugelmas, Carina, Kugelmas, Marcelo, Labidi, Asma, Lange, Naomi F., Lavine, Joel E., Lazo, Mariana, Leite, Nathalie, Lin, Han-Chieh, Lkhagvaa, Undram, Long, Michelle T., Lopez-Jaramillo, Patricio, Lozano, Adelina, Macedo, Maria Paula, Malekzadeh, Reza, Marchesini, Giulio, Marciano, Sebastian, Martinez, Kim, Martínez Vázquez, Sophia E., Mateva, Lyudmila, Mato, José M., Nlombi, Charles Mbendi, McCary, Alexis Gorden, McIntyre, Jeff, McKee, Martin, Mendive, Juan M., Mikolasevic, Ivana, Miller, Pamela S., Milovanovic, Tamara, Milton, Terri, Moreno-Alcantar, Rosalba, Morgan, Timothy R., Motala, Ayesha, Muris, Jean, Musso, Carla, Nava-González, Edna J., Negro, Francesco, Nersesov, Alexander V., Neuschwander-Tetri, Brent A., Nikolova, Dafina, Norris, Suzanne, Novak, Katja, Ocama, Ponsiano, Ong, Janus P., Ong-Go, Arlinking, Onyekwere, Charles, Padilla, Martin, Pais, Raluca, Pan, Calvin, Panduro, Arturo, Panigrahi, Manas K., Papatheodoridis, Georgios, Paruk, Imran, Patel, Keyur, Gonçalves, Carlos Penha, Figueroa, Marlene Pérez, Pérez-Escobar, Juanita, Pericàs, Juan M., Perseghin, Gianluca, Pessoa, Mário Guimarães, Petta, Salvatore, Marques Souza de Oliveira, Claudia Pinto, Prabhakaran, Dorairaj, Pyrsopoulous, Nikolaos, Rabiee, Atoosa, Ramji, Alnoor, Ratziu, Vlad, Ravendhran, Natarajan, Ray, Katrina, Roden, Michael, Romeo, Stefano, Romero-Gómez, Manuel, Rotman, Yaron, Rouabhia, Samir, Rowe, Ian A., Sadirova, Shakhlo, Alkhatry, Maryam Salem, Salupere, Riina, Satapathy, Sanjaya K., Schwimmer, Jeffrey B., Sebastiani, Giada, Seim, Lynn, Seki, Yosuke, Serme, Abdel Karim, Shapiro, David, Sharvadze, Lali, Shaw, Jonathan E., Shawa, Isaac Thom, Shenoy, Thrivikrama, Shibolet, Oren, Shimakawa, Yusuke, Shubrook, Jay H., Singh, Shivaram Prasad, Sinkala, Edford, Skladany, Lubomir, Skrypnyk, Igor, Song, Myeong Jun, Sookoian, Silvia, Sridharan, Kannan, Stefan, Norbert, Stine, Jonathan G., Stratakis, Nikolaos, Sheriff, Dhastagir Sultan, Sundaram, Shikha S., Svegliati-Baroni, Gianluca, Swain, Mark G., Tacke, Frank, Taheri, Shahrad, Tan, Soek-Siam, Tapper, Elliot B., Targher, Giovanni, Tcaciuc, Eugen, Thiele, Maja, Tiniakos, Dina, Tolmane, Ieva, Torre, Aldo, Torres, Esther A., Treeprasertsuk, Sombat, Trenell, Michael, Turcan, Svetlana, Turcanu, Adela, Valantinas, Jonas, van Kleef, Laurens A., Velarde Ruiz Velasco, Jose Antonio, Vesterhus, Mette, Vilar-Gomez, Eduardo, Waked, Imam, Wattacheril, Julia, Wedemeyer, Heiner, Wilkins, Fonda, Willemse, José, Wong, Robert J., Yilmaz, Yusuf, Yki-Järvinen, Hannele, Yu, Ming-Lung, Yumuk, Volkan, Zeybel, Müjdat, Zheng, Kenneth I., Zheng, Ming-Hua, and Huang, Terry T.-K.

Published
2023
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12. Unsupervised decoding of spinal motor neuron spike trains for estimating hand kinematics following targeted muscle reinnervation

Author

Andalib, Arash, Farina, Dario, Vujaklija, Ivan, Negro, Francesco, Aszmann, Oskar C, Bashirullah, Rizwan, and Principe, Jose C

Subjects
Electrical Engineering and Systems Science - Signal Processing
Abstract

The performance of upper-limb prostheses is currently limited by the relatively poor functionality of unintuitive control schemes. This paper proposes to extract, from multichannel electromyographic signals (EMG), motor neuron spike trains and project them into lower dimensional continuous signals, which are used as multichannel proportional inputs to control the prosthetic's actuators. These control signals are an estimation of the common synaptic input that the motor neurons receive. We use the simplest of metric learning approaches known as principal component analysis (PCA), as a linear unsupervised metric projection to extract the spectral information of high dimensional data into the subspace of the prosthetic hand degrees of freedom. We also investigate the importance of a rotation in the projection space that best aligns the PCA subspace with the space of degrees of freedom of the prosthetic hand, to attempt to approximate the sparseness properties of the motor axes (which are orthogonal), while no sparseness is enforced by PCA. Proof of concept for the feedforward path (open loop) is given by successful estimation of concurrent movements with up to three degrees of freedom. We also analyze and quantify the performance of the proposed decoding algorithm under implementation constraints and hardware limitations and propose a space-time subsampling strategy, to maximize projection fidelity, in each extracted source over time. The results confirm that the proposed decoding approach can directly project the motor neuron spike trains into kinematics for simultaneous and proportional prosthesis control that can be extended to multiple degrees of freedom. We show that the method is robust to reducing the training data in space (number of sources) and time, which makes it potentially suitable for clinical applications., Comment: 24 pages, 11 figures, 3 tables

Published
2019

13. Dependence of the static quark free energy on $\mu_B$ and the crossover temperature of $N_f = 2+1$ QCD

Author

D'Elia, Massimo, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We study the dependence of the static quark free energy on the baryon chemical potential for $N_f = 2+1$ QCD with physical quark masses, in a range of temperature spanning from 120~MeV up to 1~GeV and adopting a stout staggered discretization with two different values of the Euclidean temporal extension, $N_t = 6$ and $N_t = 8$. In order to deal with the sign problem, we exploit both Taylor expansion and analytic continuation, obtaining consistent results. We show that the dependence of the free energy on $\mu_B$ is sensitive to the location of the chiral crossover, in particular the $\mu_B$-susceptibility, i.e. the linear term in $\mu_B^2$ in the Taylor expansion of the free energy, has a peak around 150 MeV. We also discuss the behavior expected in the high temperature regime based on perturbation theory, and obtain a good quantitative agreement with numerical results., Comment: 9 pages, 6 figures

Published
2019
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20. QCD phase diagram in a magnetic background for different values of the pion mass

Author

D'Elia, Massimo, Manigrasso, Floriano, Negro, Francesco, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We investigate the behavior of the pseudo-critical temperature of $N_f = 2+1$ QCD as a function of a static magnetic background field for different values of the pion mass, going up to $m_\pi \simeq 660$ MeV. The study is performed by lattice QCD simulations, adopting a stout staggered discretization of the theory on lattices with $N_t = 6$ slices in the Euclidean temporal direction; for each value of the pion mass the temperature is changed moving along a line of constant physics. We find that the decrease of $T_c$ as a function of $B$, which is observed for physical quark masses, persists in the whole explored mass range, even if the relative variation of $T_c$ appears to be a decreasing function of $m_\pi$, approaching zero in the quenched limit. The location of $T_c$ is based on the renormalized quark condensate and its susceptibility; determinations based on the Polyakov loop lead to compatible results. On the contrary, inverse magnetic catalysis, i.e. the decrease of the quark condensate as a function of $B$ in some temperature range around $T_c$, is not observed when the pion mass is high enough. That supports the idea that inverse magnetic catalysis might be a secondary phenomenon, while the modifications induced by the magnetic background on the gauge field distribution and on the confining properties of the medium could play a primary role in the whole range of pion masses, Comment: 13 pages, 15 figures

Published
2018
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21. The curvature of the chiral pseudocritical line from LQCD: analytic continuation and Taylor expansion compared

Author

Bonati, Claudio, D'Elia, Massimo, Negro, Francesco, Sanfilippo, Francesco, and Zambello, Kevin

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We present a determination of the curvature $\kappa$ of the chiral pseudocritical line from $N_f=2+1$ lattice QCD at the physical point obtained by adopting the Taylor expansion approach. Numerical simulations performed at three lattice spacings lead to a continuum extrapolated curvature $\kappa = 0.0145(25)$, a value that is in excellent agreement with continuum limit estimates obtained via analytic continuation within the same discretization scheme, $\kappa = 0.0135(20)$. The agreement between the two calculations is a solid consistency check for both methods., Comment: Quark Matter 2018

Published
2018
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22. Topology in full QCD at high temperature: a multicanonical approach

Author

Bonati, Claudio, D'Elia, Massimo, Martinelli, Guido, Negro, Francesco, Sanfilippo, Francesco, and Todaro, Antonino

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We investigate the topological properties of $N_f = 2+1$ QCD with physical quark masses, at temperatures around 500 MeV. With the aim of obtaining a reliable sampling of topological modes in a regime where the fluctuations of the topological charge $Q$ are very rare, we adopt a multicanonical approach, adding a bias potential to the action which enhances the probability of suppressed topological sectors. This method permits to gain up to three orders of magnitude in computational power in the explored temperature regime. Results at different lattice spacings and physical spatial volumes reveal no significant finite size effects and the presence, instead, of large finite cut-off effects, with the topological susceptibility which decreases by 3-4 orders of magnitude while moving from $a \simeq 0.06$ fm towards the continuum limit. The continuum extrapolation is in agreeement with previous lattice determinations with smaller uncertainties but obtained based on ansatzes justified by several theoretical assumptions. The parameter $b_2$, related to the fourth order coefficient in the Taylor expansion of the free energy density $f(\theta)$, has instead a smooth continuum extrapolation which is in agreement with the dilute instanton gas approximation (DIGA); moreover, a direct measurement of the relative weights of the different topological sectors gives an even stronger support to the validity of DIGA., Comment: 23 pages, 13 figures

Published
2018
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23. Roberge-Weiss endpoint and chiral symmetry restoration in $N_f = 2+1$ QCD

Author

Bonati, Claudio, Calore, Enrico, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Sanfilippo, Francesco, Schifano, Sebastiano Fabio, Silvi, Giorgio, and Tripiccione, Raffaele

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We investigate the fate of the Roberge-Weiss endpoint transition and its connection with the restoration of chiral symmetry as the chiral limit of $N_f = 2+1$ QCD is approached. We adopt a stout staggered discretization on lattices with $N_t = 4$ sites in the temporal direction; the chiral limit is approached maintaining a constant physical value of the strange-to-light mass ratio and exploring three different light quark masses, corresponding to pseudo-Goldstone pion masses $m_\pi \simeq 100, 70$ and 50 MeV around the transition. A finite size scaling analysis provides evidence that the transition remains second order, in the 3D Ising universality class, in all the explored mass range. The residual chiral symmetry of the staggered action also allows us to investigate the relation between the Roberge-Weiss endpoint transition and the chiral restoration transition as the chiral limit is approached: our results, including the critical scaling of the chiral condensate, are consistent with a coincidence of the two transitions in the chiral limit; however we are not able to discern the symmetry controlling the critical behavior, because the critical indexes relevant to the scaling of the chiral condensate are very close to each other for the two possible universality classes (3D Ising or O(2))., Comment: 12 pages, 18 figure, 5 tables

Published
2018
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24. Effects of a strong magnetic field on the QCD flux tube

Author

Bonati, Claudio, Calì, Salvatore, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

In this work we investigate the effect of an external magnetic field B on the shape of flux tubes in QCD by means of lattice simulations, performed with N_f=2+1 flavors of stout improved dynamical staggered quarks with physical masses. After having discussed some difficulties in the practical definition of the flux tube at B=0, we show that these ambiguities do not affect the determination of the flux tube modifications induced by the magnetic field. Different results are obtained depending on the relative orientations of the flux tube and of the magnetic field: they confirm that the magnetic field acts as transverse confinement catalyser and longitudinal confinement inhibitor; moreover, the flux tube itself loses its axial symmetry when it is not directed along the magnetic background., Comment: 11 pages, 14 eps figures, minor corrections

Published
2018
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25. Curvature of the pseudocritical line in QCD: Taylor expansion matches analytic continuation

Author

Bonati, Claudio, D'Elia, Massimo, Negro, Francesco, Sanfilippo, Francesco, and Zambello, Kevin

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We determine the curvature of the pseudo-critical line of $N_f = 2 + 1$ QCD with physical quark masses via Taylor expansion in the quark chemical potentials. We adopt a discretization based on stout improved staggered fermions and the tree level Symanzik gauge action; the location of the pseudocritical temperature is based on chiral symmetry restoration. Simulations are performed on lattices with different temporal extent ($N_t = 6, 8, 10$), leading to a continuum extrapolated curvature $\kappa = 0.0145(25)$, which is in very good agreement with the continuum extrapolation obtained via analytic continuation and the same discretization, $\kappa = 0.0135(20)$. This result eliminates the possible tension emerging when comparing analytic continuation with earlier results obtained via Taylor expansion., Comment: 11 pages, 7 figures

Published
2018
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26. Portable multi-node LQCD Monte Carlo simulations using OpenACC

Author

Bonati, Claudio, Calore, Enrico, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Sanfilippo, Francesco, Schifano, Sebastiano Fabio, Silvi, Giorgio, and Tripiccione, Raffaele

Subjects
High Energy Physics - Lattice, Physics - Computational Physics
Abstract

This paper describes a state-of-the-art parallel Lattice QCD Monte Carlo code for staggered fermions, purposely designed to be portable across different computer architectures, including GPUs and commodity CPUs. Portability is achieved using the OpenACC parallel programming model, used to develop a code that can be compiled for several processor architectures. The paper focuses on parallelization on multiple computing nodes using OpenACC to manage parallelism within the node, and OpenMPI to manage parallelism among the nodes. We first discuss the available strategies to be adopted to maximize performances, we then describe selected relevant details of the code, and finally measure the level of performance and scaling-performance that we are able to achieve. The work focuses mainly on GPUs, which offer a significantly high level of performances for this application, but also compares with results measured on other processors., Comment: 22 pages, 8 png figures

Published
2018
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28. Gauge-invariant screening masses and static quark free energies in $N_f = 2+1$ QCD at non-zero baryon density

Author

Andreoli, Michele, Bonati, Claudio, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We discuss the extension of gauge-invariant electric and magnetic screening masses in the Quark-Gluon Plasma to the case of a finite baryon density, defining them in terms of a matrix of Polyakov loop correlators. We present lattice results for $N_f=2+1$ QCD with physical quark masses, obtained using the imaginary chemical potential approach, which indicate that the screening masses increase as a function of $\mu_B$. A separate analysis is carried out for the theoretically interesting case $\mu_B/T=3 i \pi$, where charge conjugation is not explicitly broken and the usual definition of the screening masses can be used for temperatures below the Roberge-Weiss transition. Finally, we investigate the dependence of the static quark free energy on the baryon chemical potential, showing that it is a decreasing function of $\mu_B$ which displays a peculiar behavior as the pseudocritical transition temperature at $\mu_B=0$ is approached., Comment: 11 pages, 3 tables, 10 figures

Published
2017
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34. Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

Author

Blach, Sarah, Terrault, Norah A, Tacke, Frank, Gamkrelidze, Ivane, Craxi, Antonio, Tanaka, Junko, Waked, Imam, Dore, Gregory J, Abbas, Zaigham, Abdallah, Ayat R, Abdulla, Maheeba, Aghemo, Alessio, Aho, Inka, Akarca, Ulus S, Alalwan, Abduljaleel M, Alanko Blomé, Marianne, Al-Busafi, Said A, Aleman, Soo, Alghamdi, Abdullah S, Al-Hamoudi, Waleed K, Aljumah, Abdulrahman A, Al-Naamani, Khalid, Al Serkal, Yousif M, Altraif, Ibrahim H, Anand, Anil C, Anderson, Motswedi, Andersson, Monique I, Athanasakis, Kostas, Baatarkhuu, Oidov, Bakieva, Shokhista R, Ben-Ari, Ziv, Bessone, Fernando, Biondi, Mia J, Bizri, Abdul Rahman N, Brandão-Mello, Carlos E, Brigida, Krestina, Brown, Kimberly A, Brown, Jr, Robert S, Bruggmann, Philip, Brunetto, Maurizia R, Busschots, Dana, Buti, Maria, Butsashvili, Maia, Cabezas, Joaquin, Chae, Chungman, Chaloska Ivanova, Viktorija, Chan, Henry Lik Yuen, Cheinquer, Hugo, Cheng, Kent Jason, Cheon, Myeong-Eun, Chien, Cheng-Hung, Chien, Rong-Nan, Choudhuri, Gourdas, Christensen, Peer Brehm, Chuang, Wan-Long, Chulanov, Vladimir, Cisneros, Laura E, Coco, Barbara, Contreras, Fernando A, Cornberg, Markus, Cramp, Matthew E, Crespo, Javier, Cui, Fuqiang, Cunningham, Chris W, Dagher Abou, Lucy, Dalgard, Olav, Dao, Doan Y, De Ledinghen, Victor, Derbala, Moutaz F, Deuba, Keshab, Dhindsa, Karan, Djauzi, Samsuridjal, Drazilova, Sylvia, Duberg, Ann-Sofi, Elbadri, Mohammed, El-Sayed, Manal H, Esmat, Gamal, Estes, Chris, Ezzat, Sameera, Färkkilä, Martti A, Ferradini, Laurent, Ferraz, Maria Lucia G, Ferreira, Paulo R A, Filipec Kanizaj, Tajana, Flisiak, Robert, Frankova, Sona, Fung, James, Gamkrelidze, Amiran, Gane, Edward, Garcia, Virginia, García-Samaniego, Javier, Gemilyan, Manik, Genov, Jordan, Gheorghe, Liliana S, Gholam, Pierre M, Goldis, Adrian, Gottfredsson, Magnus, Gray, Richard T, Grebely, Jason, Gschwantler, Michael, Hajarizadeh, Behzad, Hamid, Saeed S, Hamoudi, Waseem, Hatzakis, Angelos, Hellard, Margaret E, Himatt, Sayed, Hofer, Harald, Hrstic, Irena, Hunyady, Bela, Husa, Petr, Husic-Selimovic, Azra, Jafri, Wasim S M, Janicko, Martin, Janjua, Naveed, Jarcuska, Peter, Jaroszewicz, Jerzy, Jerkeman, Anna, Jeruma, Agita, Jia, Jidong, Jonasson, Jon G, Kåberg, Martin, Kaita, Kelly D E, Kaliaskarova, Kulpash S, Kao, Jia-Horng, Kasymov, Omor T, Kelly-Hanku, Angela, Khamis, Faryal, Khamis, Jawad, Khan, Aamir G, Khandu, Lekey, Khoudri, Ibtissam, Kielland, Knut B, Kim, Do Young, Kodjoh, Nicolas, Kondili, Loreta A, Krajden, Mel, Krarup, Henrik Bygum, Kristian, Pavol, Kwon, Jisoo A, Lagging, Martin, Laleman, Wim, Lao, Wai Cheung, Lavanchy, Daniel, Lázaro, Pablo, Lazarus, Jeffrey V, Lee, Alice U, Lee, Mei-Hsuan, Li, Michael K K, Liakina, Valentina, Lim, Young-Suk, Löve, Arthur, Lukšić, Boris, Machekera, Shepherd Mufudzi, Malu, Abraham O, Marinho, Rui T, Maticic, Mojca, Mekonnen, Hailemichael D, Mendes-Correa, Maria Cássia, Mendez-Sanchez, Nahum, Merat, Shahin, Meshesha, Berhane Redae, Midgard, Håvard, Mills, Mike, Mohamed, Rosmawati, Mooneyhan, Ellen, Moreno, Christophe, Muljono, David H, Müllhaupt, Beat, Musabaev, Erkin, Muyldermans, Gaëtan, Nartey, Yvonne Ayerki, Naveira, Marcelo C M, Negro, Francesco, Nersesov, Alexander V, Njouom, Richard, Ntagirabiri, Rénovat, Nurmatov, Zuridin S, Obekpa, Solomon A, Oguche, Stephen, Olafsson, Sigurdur, Ong, Janus P, Opare-Sem, Ohene K, Orrego, Mauricio, Øvrehus, Anne L, Pan, Calvin Q, Papatheodoridis, George V, Peck-Radosavljevic, Markus, Pessoa, Mário G, Phillips, Richard O, Pimenov, Nikolay, Plaseska-Karanfilska, Dijana, Prabdial-Sing, Nishi N, Puri, Pankaj, Qureshi, Huma, Rahman, Aninda, Ramji, Alnoor, Razavi-Shearer, Devin M, Razavi-Shearer, Kathryn, Ridruejo, Ezequiel, Ríos-Hincapié, Cielo Y, Rizvi, S M Shahriar, Robaeys, Geert K M M, Roberts, Lewis R, Roberts, Stuart K, Ryder, Stephen D, Sadirova, Shakhlo, Saeed, Umar, Safadi, Rifaat, Sagalova, Olga, Said, Sanaa S, Salupere, Riina, Sanai, Faisal M, Sanchez-Avila, Juan F, Saraswat, Vivek A, Sarrazin, Christoph, Sarybayeva, Gulya, Seguin-Devaux, Carole, Sharara, Ala I, Sheikh, Mahdi, Shewaye, Abate B, Sievert, William, Simojoki, Kaarlo, Simonova, Marieta Y, Sonderup, Mark W, Spearman, C Wendy, Sperl, Jan, Stauber, Rudolf E, Stedman, Catherine A M, Su, Tung-Hung, Suleiman, Anita, Sypsa, Vana, Tamayo Antabak, Natalia, Tan, Soek-Siam, Tergast, Tammo L, Thurairajah, Prem H, Tolmane, Ieva, Tomasiewicz, Krzysztof, Tsereteli, Maia, Uzochukwu, Benjamin S C, Van De Vijver, David A M C, Van Santen, Daniela K, Van Vlierberghe, Hans, Van Welzen, Berend, Vanwolleghem, Thomas, Vélez-Möller, Patricia, Villamil, Federico, Vince, Adriana, Waheed, Yasir, Weis, Nina, Wong, Vincent W-S, Yaghi, Cesar G, Yesmembetov, Kakharman, Yosry, Ayman, Yuen, Man-Fung, Yunihastuti, Evy, Zeuzem, Stefan, Zuckerman, Eli, and Razavi, Homie A

Published
2022
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39. Influence of magnetic fields on the color screening masses

Author

Bonati, Claudio, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice
Abstract

We present some recent results obtained in the study of the color magnetic and electric screening masses in the QCD plasma. In particular, we discuss how the masses get modified by strong external fields which are expected to be created in physical situations such as heavy-ion collisions., Comment: Talk presented at the 35th annual International Symposium on Lattice Field Theory (LATTICE 2017), 18-24 June 2017, Granada, Spain. 8 Pages, 7 Figures

Published
2017
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40. Flux tubes in $N_f=2+1$ QCD with external magnetic fields

Author

Bonati, Claudio, Cali, Salvatore, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice
Abstract

We study the behavior of the confining flux tube in $N_f=2+1$ QCD at the physical point, discretized with the stout smearing improved staggered quark action and the tree level Symanzik gauge action. We discuss how it depends on a uniform external magnetic field, showing how it displays anisotropies with respect to the magnetic field direction. Moreover, we compare the observed anisotropy pattern with that of the static quark-antiquark potential we obtained in our previous works., Comment: 8 pages, 35th International Symposium on Lattice Field Theory, Granada, Spain

Published
2017
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41. Screening masses in strong external magnetic fields

Author

Bonati, Claudio, D'Elia, Massimo, Mariti, Marco, Mesiti, Michele, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We present results for the (color)magnetic and (color)electric screening masses of the Quark-Gluon Plasma in the presence of an external magnetic field. The screening masses are extracted from the correlators of Polyakov loops, determined by lattice QCD simulations at the physical point. We explore temperatures in the range $200\,\mathrm{MeV}\lesssim T\lesssim 330\,\mathrm{MeV}$ and magnetic field intensities up to $|e|B \sim 1.3\,\mathrm{GeV}^2$. We find that both screening masses are increasing functions of the magnetic field and that the dependence on $B$ becomes weaker for larger temperatures. In the case of the magnetic screening mass a slight anisotropy is also observable., Comment: 8 pages, 2 tables, 10 eps figures; This version matches the published one

Published
2017
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42. Effects of magnetic fields on quark-antiquark interactions

Author

Bonati, Claudio, D'Elia, Massimo, Mariti, Marco, Mesiti, Michele, Negro, Francesco, Rucci, Andrea, and Sanfilippo, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

We discuss some recent results obtained in the study of strong quark-antiquark interactions in the presence of intense external magnetic fields by means of lattice QCD simulations. We confirm previous findings and show that both at zero and finite temperature the external field induces anisotropies in the static quark potential. An in-depth study suggests that the effects are essentially due to the variation of the string tension whose angular dependence can be nicely parametrized by the first allowed term in a Fourier expansion. In the confined phase at high temperature, we observe that the suppression of the string tension is enhanced as the strength of the external field increases. Our results support the idea that the loss of confining properties is the dominant effect related to the decrease of $T_c$ as a function of $B$., Comment: Talk presented at the 34th annual International Symposium on Lattice Field Theory (LATTICE 2016), 24-30 July 2016, University of Southampton, UK. 7 pages, 9 figures

Published
2017

43. Design and optimization of a portable LQCD Monte Carlo code using OpenACC

Author

Bonati, Claudio, Calore, Enrico, Coscetti, Simone, D'Elia, Massimo, Mesiti, Michele, Negro, Francesco, Schifano, Sebastiano Fabio, Silvi, Giorgio, and Tripiccione, Raffaele

Subjects
High Energy Physics - Lattice, Physics - Computational Physics
Abstract

The present panorama of HPC architectures is extremely heterogeneous, ranging from traditional multi-core CPU processors, supporting a wide class of applications but delivering moderate computing performance, to many-core GPUs, exploiting aggressive data-parallelism and delivering higher performances for streaming computing applications. In this scenario, code portability (and performance portability) become necessary for easy maintainability of applications; this is very relevant in scientific computing where code changes are very frequent, making it tedious and prone to error to keep different code versions aligned. In this work we present the design and optimization of a state-of-the-art production-level LQCD Monte Carlo application, using the directive-based OpenACC programming model. OpenACC abstracts parallel programming to a descriptive level, relieving programmers from specifying how codes should be mapped onto the target architecture. We describe the implementation of a code fully written in OpenACC, and show that we are able to target several different architectures, including state-of-the-art traditional CPUs and GPUs, with the same code. We also measure performance, evaluating the computing efficiency of our OpenACC code on several architectures, comparing with GPU-specific implementations and showing that a good level of performance-portability can be reached., Comment: 26 pages, 2 png figures, preprint of an article submitted for consideration in International Journal of Modern Physics C

Published
2017
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44. Voluntary co‐contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.

Author

Gomes, Matheus M., Jenz, Sophia T., Beauchamp, James A., Negro, Francesco, Heckman, C. J., and Pearcey, Gregory E. P.

Subjects
MOTOR neurons, MUSCLE contraction, ANKLE, TIBIALIS anterior, DORSIFLEXION
Abstract

Motoneuronal persistent inward currents (PICs) are facilitated by neuromodulatory inputs but are highly sensitive to local inhibitory circuits. Estimates of PICs are reduced by group Ia reciprocal inhibition, and increased with the diffuse actions of neuromodulators released during remote muscle contraction. However, it remains unknown how motoneurons function in the presence of simultaneous excitatory and inhibitory commands. To probe this topic, we investigated motor unit discharge patterns and estimated PICs during voluntary co‐contraction of ankle muscles, which simultaneously demands the contraction of agonist–antagonist pairs. Twenty participants performed triangular ramps of both co‐contraction (simultaneous dorsiflexion and plantar flexion) and isometric dorsiflexion to a peak of 30% of their maximum muscle activity from a maximal voluntary contraction. Motor unit spike trains were decomposed from high‐density surface EMG activity recorded from tibialis anterior using blind source separation algorithms. Voluntary co‐contraction altered motor unit discharge rate characteristics. Discharge rate at recruitment and peak discharge rate were modestly reduced (∼6% change; P < 0.001; d = 0.22) and increased (∼2% change; P = 0.001, d = −0.19), respectively, in the entire dataset but no changes were observed when motor units were tracked across conditions. The largest effects during co‐contraction were that estimates of PICs (ΔF) were reduced by ∼20% (4.47 vs. 5.57 pulses per second during isometric dorsiflexion; P < 0.001, d = 0.641). These findings suggest that, during voluntary co‐contraction, the inhibitory input from the antagonist muscle overcomes the additional excitatory and neuromodulatory drive that may occur due to the co‐contraction of the antagonist muscle, which constrains PIC behaviour. Key points: Voluntary co‐contraction is a unique motor behaviour that concurrently provides excitatory and inhibitory synaptic input to motoneurons.Co‐contraction of agonist–antagonist pairs alters agonist motor unit discharge characteristics, consistent with reductions in persistent inward current magnitude. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Durability against wood-destroying fungi of sweet chestnut and mixed sweet chestnut-poplar OSB.

Author

Thévenon, Marie-France, Cremonini, Corrado, Negro, Francesco, and Zanuttini, Roberto

Subjects
CHESTNUT, WOOD-decaying fungi, ORIENTED strand board, POPLARS, WOOD decay, PLYWOOD, WOOD, DURABILITY
Abstract

The demand for wooden raw materials is constantly on the rise. Meeting this interest requires developing new timber supply chains, tackling illegal trade, using timber more efficiently, and enhancing the service life of wood-based products. From this point of view, sweet chestnut wood can be successfully used, alone or mixed with poplar, to manufacture Oriented Strand Board (OSB). This article assesses the fungal resistance of OSB/3 (load-bearing boards for use in humid conditions) made with different fractions of poplar (P) and sweet chestnut (SC) wood, in order to take advantage of the protective action of the tannins contained in the latter. Four types of OSB/3 were manufactured on an industrial scale: 100% P; 80% P and 20% SC; 50% P and 50% SC; 100% SC. The durability of the experimental boards was determined in accordance with the EN 113-3 standard (2023). No significant differences in mass loss were found for OSB/3 with different sweet chestnut wood fractions. Instead, the mass loss of these panels was significantly lower (i.e. fungal resistance was higher) than that of the poplar OSB/3 and poplar plywood tested for comparison. Based on the results, the use of sweet chestnut wood has interesting potential for the manufacturing of OSB/3 made with adequate gluing quality, suitable for applications in environments where fungal decay may occur. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Recent progress on QCD inputs for axion phenomenology

Author

Bonati, Claudio, D'Elia, Massimo, Mariti, Marco, Martinelli, Guido, Mesiti, Michele, Negro, Francesco, Sanfilippo, Francesco, and Villadoro, Giovanni

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

The properties of the QCD axion are strictly related to the dependence of strong interactions on the topological parameter theta. We present a determination of the topological properties of QCD for temperatures up to around 600 MeV, obtained by lattice QCD simulations with 2+1 flavors and physical quark masses. Numerical results for the topological susceptibility, when compared to instanton gas computations, differ both in size and in the temperature dependence. We discuss the implications of such findings for axion phenomenology, also in comparison to similar studies in the literature, and the prospects for future investigations., Comment: Invited talk at XII Quark Confinement, 29 August - 3 September, 2016, Thessaloniki, Greece, 9 pages, 6 figures

Published
2016
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47. Field-strength correlators for QCD in a magnetic background

Author

Meggiolaro, Enrico, D'Elia, Massimo, Mesiti, Michele, and Negro, Francesco

Subjects
High Energy Physics - Lattice, High Energy Physics - Phenomenology, High Energy Physics - Theory
Abstract

We present the results of an exploratory study (by means of Monte Carlo simulations on the lattice) of the properties of the gauge-invariant two-point correlation functions of the gauge-field strengths for $N_f=2$ QCD at zero temperature and in the presence of a magnetic background field: the analysis provides evidence for the emergence of anisotropies in the nonperturbative part of the correlators and for an increase of the gluon condensate as a function of the external magnetic field., Comment: To appear in the proceedings of the "38th International Conference on High Energy Physics" (ICHEP 2016), Chicago (USA), 3-10 August 2016; 6 pages, 1 figure

Published
2016

48. Real-World Outcomes in Historically Underserved Patients with Chronic Hepatitis C Infection Treated with Glecaprevir/Pibrentasvir

Author

Aghemo, Alessio, Horsmans, Yves, Bourgeois, Stefan, Bondin, Mark, Gschwantler, Michael, Hofer, Harald, Semmo, Nasser, Negro, Francesco, Zhang, Zhenzhen, Marcinak, John, Veitsman, Ella, Hazzan, Rawi, Mimidis, Konstantinos, Goulis, Ioannis, Marques, Nuno, Flisiak, Robert, Mazur, Wlodzimierz, Roncero, Carlos, Marra, Fiona, Pageaux, Georges Philippe, Asselah, Tarik, and Lampertico, Pietro

Published
2021
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49. Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

Author

Younossi, Zobair M, Loomba, Rohit, Anstee, Quentin M, Rinella, Mary E, Bugianesi, Elisabetta, Marchesini, Giulio, Neuschwander‐Tetri, Brent A, Serfaty, Lawrence, Negro, Francesco, Caldwell, Stephen H, Ratziu, Vlad, Corey, Kathleen E, Friedman, Scott L, Abdelmalek, Manal F, Harrison, Stephen A, Sanyal, Arun J, Lavine, Joel E, Mathurin, Philippe, Charlton, Michael R, Goodman, Zachary D, Chalasani, Naga P, Kowdley, Kris V, George, Jacob, and Lindor, Keith

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Disease, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Clinical Research, Hepatitis, Oral and gastrointestinal, Good Health and Well Being, Biomarkers, Collagen, Humans, Liver, Liver Cirrhosis, Non-alcoholic Fatty Liver Disease, Medical Biochemistry and Metabolomics, Immunology, Gastroenterology & Hepatology, Clinical sciences
Abstract

Nonalcoholic fatty liver disease (NAFLD) is a spectrum comprised of isolated steatosis, nonalcoholic steatohepatitis (NASH), advanced fibrosis, and cirrhosis. The majority of NAFLD subjects do not have NASH and do not carry a significant risk for liver-related adverse outcomes (cirrhosis and mortality). Globally, the prevalence of NAFLD is approximately 25%. In Asia, a gradient of high to low prevalence rates is noted from urban to rural areas. Given the prevalence of NAFLD, the clinical and economic burden of NAFLD and NASH can be substantial. With increasing recognition of NASH as an important liver disease, the diagnosis of NASH still requires a liver biopsy that is suboptimal. Although liver biopsy is the most accurate modality to diagnose and stage the severity of NASH, this method suffers from being invasive, costly, associated with potential complications, and plagued with interobserver variability of individual pathological features. A number of noninvasive modalities to diagnose NASH and stage liver fibrosis are being developed. These modalities include predictive models (NAFLD fibrosis score) and serum biomarkers such as enhanced liver fibrosis (ELF). Other tests are based on radiological techniques, such as transient elastography (TE) or magnetic resonance elastography (MRE), which are used to estimate liver stiffness as a potential surrogate of hepatic fibrosis. Although a dynamic field of research, most of these diagnostic modalities have area under the curve ranging between 0.76 and 0.90%, with MRE having the best predictive performance. In summary, developing safe and easily accessible noninvasive modalities to accurately diagnose and monitor NASH and associated fibrosis is of utmost importance in clinical practice and clinical research. These tests are not only important to risk stratify subjects at the greatest risk for progressive liver disease, but also to serve as appropriate surrogate endpoints for therapeutic clinical trials of NASH. (Hepatology 2018;68:349-360).

Published
2018

50. Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Author

Younossi, Zobair M, Loomba, Rohit, Rinella, Mary E, Bugianesi, Elisabetta, Marchesini, Giulio, Neuschwander‐Tetri, Brent A, Serfaty, Lawrence, Negro, Francesco, Caldwell, Stephen H, Ratziu, Vlad, Corey, Kathleen E, Friedman, Scott L, Abdelmalek, Manal F, Harrison, Stephen A, Sanyal, Arun J, Lavine, Joel E, Mathurin, Philippe, Charlton, Michael R, Chalasani, Naga P, Anstee, Quentin M, Kowdley, Kris V, George, Jacob, Goodman, Zachary D, and Lindor, Keith

Subjects
Hepatitis, Liver Disease, Chronic Liver Disease and Cirrhosis, Prevention, Clinical Trials and Supportive Activities, Clinical Research, Digestive Diseases, Rare Diseases, Oral and gastrointestinal, Good Health and Well Being, Clinical Trials as Topic, Exercise, Humans, Liver Transplantation, Non-alcoholic Fatty Liver Disease, Obesity, Weight Loss, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology, Gastroenterology & Hepatology
Abstract

Nonalcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH), are rapidly becoming among the top causes of cirrhosis, hepatocellular carcinoma, and indications for liver transplantation. Other than lifestyle modification through diet and exercise, there are currently no other approved treatments for NASH/NAFLD. Although weight loss can be effective, it is difficult to achieve and sustain. In contrast, bariatric surgery can improve metabolic conditions associated with NAFLD, and has been shown to improve liver histology. To have approved regimens for the treatment of NASH/NAFLD, several issues must be addressed. First, all stakeholders must agree on the most appropriate clinical trial endpoints for NASH. Currently, resolution of NASH (without worsening fibrosis) or reduction of fibrosis stage (without worsening NASH) are the accepted endpoints by the regulatory authorities. It is important to recognize the prognostic implication of histologic features of NASH. In this context, although histologic NASH has been associated with advanced fibrosis, it is not an independent predictor of long-term mortality. In contrast, there are significant data to suggest that fibrosis stage is the only robust and independent predictor of liver-related mortality. In addition to the primary endpoints, several important secondary endpoints, including noninvasive biomarkers, long-term outcomes, and patient-reported outcomes must be considered. In 2018, a few phase 3 clinical trials for the treatment of NASH have been initiated. Additionally, a number of phase 2a and 2b clinical trials targeting different pathogenic pathways in NASH are in the pipeline of emerging therapies.ConclusionOver the next 5 years, some of these regimens are expected to provide potential new treatment options for patients with NASH/NAFLD. (Hepatology 2018;68:361-371).

Published
2018

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