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93 results on '"NEDD8 Protein genetics"'

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1. Upregulation of Cullin1 neddylation promotes glycolysis and M1 polarization of macrophage via NF-κB p65 pathway in sepsis.

2. Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation.

3. TRAF2 associates with cullin neddylation complex assembly.

4. Inhibition of neddylation disturbs zygotic genome activation through histone modification change and leads to early development arrest in mouse embryos.

5. DCUN1D1 and neddylation: Potential targets for cancer therapy.

6. Crotonylation of NAE1 Modulates Cardiac Hypertrophy via Gelsolin Neddylation.

7. Neddylation signaling inactivation by tetracaine hydrochloride suppresses cell proliferation and alleviates vemurafenib-resistance of melanoma.

8. The Role of Neddylation in Malaria Parasites.

9. Prognostic prediction and immune checkpoint profiling in glioma patients through neddylation-associated features.

10. Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration.

11. NEDD8 enhances Hippo signaling by mediating YAP1 neddylation.

12. Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses.

13. Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway.

14. Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.

15. MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation.

16. RAPSYN-mediated neddylation of BCR-ABL alternatively determines the fate of Philadelphia chromosome-positive leukemia.

17. Targeted degradation of oncogenic BCR-ABL by silencing the gene of NEDD8 E3 ligase RAPSYN.

18. Identification of Potential Neddylation-related Key Genes in Ischemic Stroke based on Machine Learning Methods.

19. Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.

20. Mechanism of Ψ-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase.

21. Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).

22. Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy.

23. Targeting neddylation as a novel approach to lung cancer treatment (Review).

24. Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration.

25. Inhibition of NEDD8 NEDDylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway.

26. DYRK2 maintains genome stability via neddylation of cullins in response to DNA damage.

27. Blocking neddylation elicits antiviral effect against hepatitis B virus replication.

28. Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.

29. Quantitative analyses for effects of neddylation on CRL2 VHL substrate ubiquitination and degradation.

30. Analysis of multiple gene co-expression networks to discover interactions favoring CFTR biogenesis and ΔF508-CFTR rescue.

31. A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).

32. Structural and functional consequences of NEDD8 phosphorylation.

33. CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation.

34. Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation.

35. NEDD8 Deamidation Inhibits Cullin RING Ligase Dynamics.

36. MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma.

37. Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas.

38. Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade.

39. Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.

40. Neddylation of PTEN regulates its nuclear import and promotes tumor development.

41. TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.

42. 20-HETE downregulates Na/K-ATPase α1 expression via the ubiquitination pathway.

43. Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.

44. A competing endogenous RNA network reveals key lncRNAs associated with sepsis.

45. Characterization of Plasmodium falciparum NEDD8 and identification of cullins as its substrates.

46. Neddylation is critical to cortical development by regulating Wnt/β-catenin signaling.

47. Ubiquitin-Like Modifiers: Emerging Regulators of Protozoan Parasites.

48. Neddylation promotes protein translocation between the cytoplasm and nucleus.

49. Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27 Kip1 .

50. Neddylation-mediated Nedd4-2 activation regulates ubiquitination modification of renal NBCe1.

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