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Background/Aim: Familial resemblance in dietary patterns has been a subject of interest, with both genetic and environmental factors playing crucial roles. This study aims to investigate trends in macronutrient intake correlations over a 9-year period among different familial pairs, including parent-offspring, siblings, and spouses, using data from the Tehran Lipid and Glucose Study (TLGS). Methods: This longitudinal study, conducted within the framework of the TLGS, analyzed data from 1,814 families over a 9-year period. Dietary intakes were assessed using a validated 168-item food frequency questionnaire. Macronutrient intakes were calculated and adjusted for age. Familial correlations were estimated using intraclass correlation coefficients for various familial pairs (parent-offspring, siblings, and spouses) across four consecutive surveys. Changes in correlations were analyzed over 3-year, 6-year, and 9-year intervals, as well as across all four surveys, to determine overall trends in macronutrient intake correlations. Results: The results revealed diverse trends in intake correlations for carbohydrates, proteins, fats, and specific fatty acids across familial relationships. Parent-offspring dyads exhibited varied patterns, with some nutrients showing regression to the mean. Sister-sister pairs demonstrated strengthening correlations for energy, carbohydrates, fats, and saturated fatty acids over time. Conversely, brother-sister pairs displayed weakening correlations for most macronutrients, particularly energy, proteins, cholesterol, and fiber. Spouse correlations tended towards regression to the mean for energy, carbohydrates, and fats, and fiber. Conclusions: The present study illuminates the dynamic nature of familial dietary correlations over time. The contrasting trends between sister-sister and brother-sister dyads suggest a significant influence of gender on shared dietary patterns. These findings underscore the complex interplay of genetic and environmental factors in shaping family dietary behaviors and highlight the importance of considering both gender and relationship type when examining familial nutritional habits. [ABSTRACT FROM AUTHOR]

ABSTRACT Dementia is a public health concern in the aging population with an estimated 55 million people impacted globally. Public health initiatives that focus on minimizing dementia risk factors may support efforts to reduce the incidence of dementia in at‐risk populations. Exposomics considers both modifiable and non‐modifiable risk factors for disease, including genetic changes with age and lifetime exposures to environmental, social, and behavioral risk factors. Dementia precursors may remain undetected for up to 20 years. An understanding and application of the dementia exposome may promote healthy brain interventions, screening, and risk mitigation. The proposed dementia public health exposome (DPHE) provides a framework for understanding and addressing the complex interactions between genetics, health behavior, and environment (natural, built, and social) linked to modifiable and non‐modifiable risk factors for dementia. The DPHE may be used to inform public health strategies and advancements in healthy brain initiatives. [ABSTRACT FROM AUTHOR]

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Understanding the extent to which genetics × environment plays a role in shaping individual strategies to environmental challenges is of considerable interest for future selection of more resilient animals. The objective of this study was to evaluate the metabolic responses of goats, selected for functional longevity, to a nutritional challenge. This evaluation was based on plasma metabolites and was repeated across 2 experimental farms over 2 years. We carried out 6 different experimental trials from 2018 to 2022 (4 trials on site Bourges, 2018–2021 and 2 trials on site Grignon, 2021–2022) in which 267 first kidding goats, daughters of Alpine bucks divergently selected for functional longevity, longevity plus (n = 137), and longevity minus (n = 130), were exposed to a 2-d nutritional challenge in early lactation. The experiments consisted of a 5 or 7-d control period (prechallenge) on a standard lactation diet followed by a 2-d nutritional challenge with straw-only feeding, and then a 7- or 10-d recovery period on a standard lactation diet, for site Bourges and Grignon, respectively. During the challenge plasma metabolite composition was measured. Linear mixed models were used to analyze all traits, considering the individual as a random effect and the 2 × 2 treatments (i.e., genetic line and year nested in site) and litter size as fixed effects. The linear mixed-effects model using a piecewise arrangement was used to analyze the response/recovery profiles to the nutritional challenge. The estimates of the random effect for each individual, using the mixed models without the fixed effects of genetic line, were used in a sparse partial least square discriminant analysis (sPLS-DA) to compare the goat metabolism response to the challenge on a multivariate scale. The plasma glucose, BHB, nonesterified fatty acids (NEFA), and urea concentrations significantly responded to the 2-d nutritional challenge. Selection for functional longevity did not affect plasma glucose, NEFA, BHB, and urea response/recoveries to a 2-d nutritional challenge. However, site, trial, and litter size significantly affected these responses. Moreover, the plasma metabolites seem not to fully recover to prechallenge levels after the recovery phase. The sPLS-DA analysis did not discriminate between the 2 longevity lines. We observed meaningful between-individuals variability in plasma BHB, especially on the prechallenge and rate of response and rate of recovery from the 2-d nutritional challenge (CV = 26.2%, 36.1%, and 41.2%, repeatability = 0.749, 0.322, and 0.741, respectively). Plasma NEFA recovery from challenge also demonstrated high between-individuals variability (CV = 16.4%, repeatability = 0.323). Selection for functional longevity did not affect plasma metabolites responses to a 2-d nutritional challenge in dairy goats. Plasma NEFA and BHB response and recovery presented high between-individuals variability, indicating that individual adaptative characteristics to nutritional challenges are not related to the environmental conditions but to inherent individual characteristics. [ABSTRACT FROM AUTHOR]

Recent scholarship on organizational change has de-emphasized environment, core competencies at founding, and structural inertia in favor of the study of strategic management. We encourage renewed consideration of forces over which managers have less control. In a reconsideration and conceptual extension of Hager and Brudney's nature and nurture influences on nonprofit efforts to recruit volunteers, we introduce central dimensions of organizational ecology theory. We assert that more attention to the tenets of organizational ecology will sensitize the field to the influence of environments in which organizations operate. Consistent with Hager and Brudney, our longitudinal assessment of nonprofits not only records the value of purposeful adjustments of programs but also highlights how the evolution of structural conditions plays an essential role in core organizational outcomes in volunteer management. Beyond the usual validation of strategic management, we emphasize that the influence of environment and structure is an essential determinant of the fates of organizations over time. [ABSTRACT FROM AUTHOR]

Background Methods Results Conclusions Food fussiness (FF) describes the tendency to eat a small range of foods, due to pickiness and/or reluctance to try new foods. A common behaviour during childhood, and a considerable cause of caregiver concern; its causes are poorly understood. This is the first twin study of genetic and environmental contributions to the developmental trajectory of FF from toddlerhood to early adolescence, and stability and change over time.Participants were from Gemini, a population‐based British cohort of n = 4,804 twins born in 2007. Parents reported on FF using the Child Eating Behaviour Questionnaire ‘FF’ scale when children were 16 months (n = 3,854), 3 (n = 2,666), 5 (n = 2,098), 7 (n = 703), and 13 years old (n = 970). A mixed linear model examined the trajectory of FF, and a correlated factors twin model quantified genetic and environmental contributions to variation in and covariation between trajectory parameters. A longitudinal Cholesky twin model examined genetic and environmental influences on FF at each discrete age.We modelled a single FF trajectory for all children, which was characterised by increases from 16 months to 7 years, followed by a slight decline from 7 to 13 years. All trajectory parameters were under strong genetic influence (>70%) that was largely shared, indicated by high genetic correlations. Discrete age analyses showed that genetic influence on FF increased significantly after toddlerhood (16 months: 60%, 95% CI: 53%–67%; 3 years: 83%; 81%–86%), with continuing genetic influence as indicated by significant genetic overlap across every age. Shared environmental influences were only significant during toddlerhood. Unique environmental influences explained 15%–26% of the variance over time, with some enduring influence from 5 years onwards.Individual differences in FF were largely explained by genetic factors at all ages. Fussy eating also shows a significant proportion of environmental influence, especially in toddlerhood, and may, therefore, benefit from early interventions throughout childhood. Future work needs to refine the FF trajectory and explore specific trajectory classes. [ABSTRACT FROM AUTHOR]

Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains: the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders. [ABSTRACT FROM AUTHOR]

Improving the understanding of the complex relationship between genetic predispositions, environmental influences, and sociocultural factors in the development and progression of mental illness is crucial for optimizing treatment efficacy and addressing longstanding health disparities. This paper discusses the ethical, legal, and social implications (ELSI) of recent advancements in biomedical research, particularly in genome-wide association studies (GWAS), phenome-wide association studies (PheWAS), and genome-wide environment interaction studies (GWEIS). Despite recent scientific progresses, challenges such as inadequate study methodology (e.g., correlational studies) and lack of diversity within study samples persist. Recent discoveries of several genetic variants of diseases, could augment and improve, or even challenge, existing understanding of the onset and management of mental illness. Leveraging real-world data (RWD), including electronic health record data (EHRs) focused on social determinant of health alongside biobank data, offers further opportunities to enhance the understanding of gene-environment interactions and inform efforts for reducing disparities in mental healthcare. Increased knowledge can support timely, holistic, evidence-based, and personalized care. Addressing ELSI considerations and maximizing the use of RWD is essential for advancing ethical and inclusive psychiatric genetics research, ultimately improving patient outcomes and promoting equitable access to evidence-based treatments. [ABSTRACT FROM AUTHOR]

Background: In the excitement about genomics, it is easy to lose sight of one of the most important findings from behavioural genetics: At least half of the variance of psychopathology is caused by environmental effects that are not shared by children growing up in the same family, which includes error of measurement. However, a 30‐year search for the systematic causes of nonshared environment in a line‐up of the usual suspects, especially parenting, has not identified the culprits. Method: I briefly review this research, but primarily consider the conceptual framework of the search for 'missing' nonshared environmental effects. Results: The search has focused on exogenous events like parenting, but nonshared environment might not be caused by anything we would call an event. Instead, it might reflect endogenous processes such as noisy biological systems (such as somatic mutations and epigenetics) or, at a psychological level, idiosyncratic subjective perceptions of past and present experiences, which could be called nonshared environmental experience to distinguish it from exogenous events. Although real, nonshared environment might be random in the philosophy of science sense of being unpredictable, even though it can have stable effects that predict subsequent behaviour. Conclusion: I wade into the weeds of randomness and suggest that this so‐called 'gloomy prospect' might not be so gloomy. [ABSTRACT FROM AUTHOR]

The purpose of this paper is to discuss the idea that the misdeeds of ancestors will have negative consequences for their descendants, as encapsulated by biblical quotes about 'the sins of the fathers'. The prevalence of these ideas in religion and folklore, through the notion of family curses, is discussed, as is an analysis of what constitutes 'sin'. How the so-called sins of our forebears might reach across future generations is considered in two ways. The first is that detrimental characteristics, behaviours, and health conditions can be transmitted to descendants via genetic, epigenetic, environmental, and psychosocial mechanisms (and the interactions between these). The second is that descendants can feel guilt and shame as a result of the actions of their ancestors. Overcoming the effects of ancestral fault and disadvantage may occur through improvements in living standards, medical advances, more tolerant and inclusive cultural beliefs, as well as other environmental and social changes. These processes are also likely to be assisted by greater knowledge and understanding of one's own family history. Such knowledge, in historical context, has the potential to facilitate both personal psychotherapeutic change and decisions about appropriate reparations where these are indicated. [ABSTRACT FROM AUTHOR]

Copyright of Kölner Zeitschrift für Soziologie und Sozialpsychologie ( KZfSS) is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Recent decades have seen substantial increases in wealth inequality; this is particularly troubling given the high persistence of this inequality across generations. Yet, we have surprisingly little understanding of how and why wealth is transmitted across generations. Is this persistence driven by innate biological differences across families? Or is it driven by growing up in a different environment with access to different opportunities? In the 2024 Downing Public Lecture, Professor Sandra E. Black discusses the economics research that tries to answer this question, focusing on how one can disentangle the role of nature versus nurture. [ABSTRACT FROM AUTHOR]

A major challenge to implementing effective soil health assessments is how to distinguish the effects of management from underlying soil variability driven by inherent soil properties. This challenge has important consequences for the use of soil health indicators as tools for monitoring and assessment because soil‐forming factors constrain the range of indicator values and the magnitude of management‐induced changes. Here, we present results from a statewide survey of 15 soil health indicators measured on 30 fields on commercial farms across four major land resource areas in Minnesota. Fields included in the study differed in tillage, cover crop implementation, and crop rotation. Within each field, we collected samples from upper and lower hillslope positions to quantify the effect of topography. We consistently detected differences in soil health indicators between regions (13/15 indicators) and hillslope positions (8/15 indicators). However, only wet aggregate stability was sensitive to management across regions and years, highlighting the importance of physical indicators of soil health. This result was surprising in light of existing literature supporting the sensitivity of many soil health indicators to management, but it is consistent with other studies conducted in high organic matter soils in the Upper US Midwest. Our results highlight the need for regionally representative datasets to guide the development of interpretations and benchmarks for soil health indicators. This is particularly important when soil health indicators are applied outside traditional research contexts (such as in commercial soil health testing), where interpretation must take place without the benefit of historical baseline data. [ABSTRACT FROM AUTHOR]

Atlantic salmon (Salmo salar) is an important source of food globally; however, fillet color can significantly affect consumer purchasing, leading to potential food waste. Fish diets can be supplemented with astaxanthin to increase the organic pigment, carotenoid, responsible for flesh coloration; however, there is variation in the amount of overall fillet coloration in response to feeding astaxanthin. The uptake of this pigment is influenced by the environment and genetics and has been shown to be heritable. Therefore, we set out to determine the genomic associations of two separate year classes of farmed North American Atlantic salmon with measured Minolta Chroma Meter (lightness, redness, and yellowness) and SalmoFan phenotypic traits. Using ASReml-R genome-wide association, two genetic markers on chromosome 26 were significantly associated with almost all color traits, and these two markers explained between 6.0% and 12.5% of the variances. The genomic region on chromosome 26 was importantly found to be associated with the beta-carotene oxygenase 1 (bco1) gene, which is essential in the conversion of beta-carotenoids to vitamin A, implying that this gene may also play an important role in flesh coloration in North American Atlantic salmon. Additionally, there were several genomic regions significantly associated with color traits, in which the accompanying genes had functions in line with thermogenesis, immune function, and pathogenic responses. Understanding how environmental and genetic factors work together to affect fillet quality traits will help inform genetic improvement. [ABSTRACT FROM AUTHOR]

Modern societies are challenged by a range of problems; most, if not all, are aggravated by the way people behave. Our minds are shaped by the combined effect of nature and nurture. The only practical option for modifying behavior is to adjust the impact of the environment. All societies try to mold their citizens; thus, the question is not whether we should attempt to form the brains of future generations, but how to optimize the outcome. I shall discuss desirable features, brain plasticity, and strategies for enhancing society by tweaking the mindset, and thus the behavioral propensities, of the population. [ABSTRACT FROM AUTHOR]

Copyright of International Journal of Positivity & Well-Being (IJPW) is the property of International Journal of Positivity & Well-Being (IJPW) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The brain undergoes extensive development during late childhood and early adolescence. Cortical thinning is a prominent feature of this development, and some researchers have suggested that differences in cortical thickness may be related to internalizing symptoms, which typically increase during the same period. However, research has yielded inconclusive results. We utilized a new method that estimates the combined effect of individual differences in vertex‐wise cortical thickness on internalizing symptoms. This approach allows for many small effects to be distributed across the cortex and avoids the necessity of correcting for multiple tests. Using a sample of 8763 children aged 8.9 to 11.1 from the ABCD study, we decomposed the total variation in caregiver‐reported internalizing symptoms into differences in cortical thickness, additive genetics, and shared family environmental factors and unique environmental factors. Our results indicated that individual differences in cortical thickness accounted for less than 0.5% of the variation in internalizing symptoms. In contrast, the analysis revealed a substantial effect of additive genetics and family environmental factors on the different components of internalizing symptoms, ranging from 06% to 48% and from 0% to 34%, respectively. Overall, while this study found a minimal association between cortical thickness and internalizing symptoms, additive genetics, and familial environmental factors appear to be of importance for describing differences in internalizing symptoms in late childhood. Research Highlights: We utilized a new method for modelling the total contribution of vertex‐wise individual differences in cortical thickness to internalizing symptoms in late childhood.The total contribution of individual differences in cortical thickness accounted for <0.5% of the variance in internalizing symptoms.Additive genetics and shared family environmental variation accounted for 17% and 34% of the variance in internalizing symptoms, respectively.Our results suggest that cortical thickness is not an important indicator for internalizing symptoms in childhood, whereas genetic and environmental differences have a substantial impact. [ABSTRACT FROM AUTHOR]

We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 (BARD1) gene that were predicted to be damaging by computational analyses. We conducted functional assays, essential for accurate interpretation of missense variants, in primary fibroblasts that we established in tissue culture from a patient carrying the heterozygous BARD1V523A mutation. We found that these cells had genomic instability, reduced DNA repair, and impaired apoptosis. Investigating the underlying signaling pathways, we found that BARD1 forms a trimeric protein complex with p53 and SERCA2 that regulates calcium signaling and apoptosis. We validated these findings in BARD1-silenced primary human mesothelial cells exposed to asbestos. Our study elucidated mechanisms of BARD1 activity and revealed that heterozygous germline BARD1 mutations favor the development of mesothelioma and increase the susceptibility to asbestos carcinogenesis. These mesotheliomas are significantly less aggressive compared to mesotheliomas in asbestos workers. [ABSTRACT FROM AUTHOR]

Simple Summary: Similar to humans, dogs could suffer a syndrome similar to Attention-Deficit/Hyperactivity Disorder (ADHD). Several studies suggest that dogs can serve as a model for studying ADHD. This condition leads to behavioral issues like impulsivity, attention problems, hyperactivity, and sometimes aggression, affecting both the dog's and their caregiver's quality of life. ADHD-like behavior in dogs is linked to disruptions in neurotransmitters like serotonin and dopamine, similar to humans. It seems to result from a mix of genetics and environment. In addition to the mentioned symptoms, dogs with ADHD-like behavior may also display compulsive behaviors, aggression, inappropriate elimination, fearfulness, epilepsy, foreign body ingestion, and itchiness. While there is no clear veterinary diagnosis for ADHD-like behavior in dogs, validated questionnaires can be helpful, but these cannot be used as a unique diagnostic tool. Treatment may involve medications like fluoxetine, along with environmental enrichment, relaxation techniques, and behavior modification to improve the dog's and caregiver's quality of life. Similar to humans, dogs could suffer an Attention-Deficit/Hyperactivity Disorder-like syndrome (ADHD-like). In fact, several studies highlight the use of dogs as a model for studying ADHD. This condition entails behavioral problems expressed through impulsivity, attention issues, hyperactivity, and/or aggression, compromising the quality of life for both the caregiver and the dog. The pathophysiology of ADHD-like is complex and is associated with dysregulation of various neurotransmitters such as serotonin and dopamine. The expression of ADHD-like behavior in dogs would appear to depend on a classical gene–environment interaction as is the case with many neurological disorders in humans. In addition to the described symptomatology, ADHD-like dogs can exhibit strong comorbidities with compulsive behaviors, aggressiveness, inappropriate elimination and fearfulness, in addition to epilepsy, foreign body ingestion, and pruritus. In spite of the fact that there is no veterinary consensus about the diagnosis of ADHD-like, some validated questionnaires could be helpful, but these cannot be used as a unique diagnostic tool. The use of drugs, such as fluoxetine, in addition to an adequate environmental enrichment, relaxation protocols, and behavior modification can achieve an adequate quality of life for both the dog and caregivers. [ABSTRACT FROM AUTHOR]

Introduction: Crown width (CW) is a significant variable of tree growth, but measuring crown width is laborious and time-consuming. Diameter at breast height (D) is a commonly used growth variable in crown width prediction. Here, a CW-D model was developed to estimate the crown width of larch. Methods: The data of 1,515 larch trees were collected in Guandi mountain, the northern China. We chose linear function, quadratic function, and other form of base functions to develop the CW models, and we introduced non-linear least squares techniques (NLS), non-linear mixed-effect (NLME), and Bayesian method in modeling process. Because the data was from different plot, we added a plot level random effect in NLME method to predict the effect from environment. For equally comparing the Bayesian method with the NLME, we also added the plot level random effect to the Bayesian MCMC procedure. We selected Akaike's information criterion and logarithm likelihood to evaluate NLS and NLME models, and chose deviance information criterion and stationary test to test Bayesian method. These methods had another three same indicators (the determination coeffcient, rootmean square error, andmean absolute deviation) in model evaluation. Results and discussion: Heteroskedasticity wasn't occurred in this study. The model I.2 (quadratic formula) showed a best fitting effect in each method, and Bayesian method with random effect was slightly superior than other methods. Therefore, the selected final model was quadratic function by Bayesian method with plot level random effect, this combination had the highest prediction accuracy in the larch trees' crown width estimation of Guandi mountain. [ABSTRACT FROM AUTHOR]

Reflexive environmental law (REL) enables an understanding of how law builds potential for private company reflexivity. Reflexivity helps to avoid lock-in, and enhances learning and self-organization to resolve complex sustainability challenges. Thus far, REL theory has excluded traditional command-and-control regulation as a form of REL. This limits the potential of REL to understand how legislation can drive reflexivity and create more effective governance. Our framework expands the definition of REL and sets out six types of regulatory instrument found in legislation that may, or may not, constitute forms of REL. The framework comprises three reflexive drivers – autonomy, accountability, and adjustability – and, under these, eleven REL techniques. Through examples taken from European environmental legislation, we explain the drivers' relationship with different regulatory instruments. This taxonomy empowers regulators and scholars to understand both the reflexive potential of regulatory instruments and the possibility to make instruments more reflexive in specific contexts. [ABSTRACT FROM AUTHOR]

Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders. Mental disorders are often linked with cardiometabolic disorders, but the mechanism remains unclear. Here, the authors use comprehensive health data from Denmark and to shed light on the genetic and environmental factors influencing the co-occurrence of six mental disorders and 15 cardiometabolic disorders. [ABSTRACT FROM AUTHOR]

Body mass results from a complex interplay between genetics and environment. Previous studies of the genetic contribution to body mass have excluded repetitive regions due to the technical limitations of platforms used for population scale studies. Here we apply genome-wide approaches, identifying an association between adult body mass and the copy number (CN) of 47S-ribosomal DNA (rDNA). rDNA codes for the 18 S, 5.8 S and 28 S ribosomal RNA (rRNA) components of the ribosome. In mammals, there are hundreds of copies of these genes. Inter-individual variation in the rDNA CN has not previously been associated with a mammalian phenotype. Here, we show that rDNA CN variation associates with post-pubertal growth rate in rats and body mass index in adult humans. rDNA CN is not associated with rRNA transcription rates in adult tissues, suggesting the mechanistic link occurs earlier in development. This aligns with the observation that the association emerges by early adulthood. Many genetic variants have been associated with body size, but the contribution of copy number of rDNA is unknown. Here, the authors explore the association between rDNA copy number and body size in both rats and humans, finding that lower rDNA CN is associated with higher weight and BMI. [ABSTRACT FROM AUTHOR]

Chromatin is densely packed with nucleosomes, which limits the accessibility of many chromatin-associated proteins. Pioneer factors (PFs) are usually viewed as a special group of sequence-specific transcription factors (TFs) that can recognize nucleosome-embedded motifs, invade compact chromatin, and generate open chromatin regions. Through this process, PFs initiate a cascade of events that play key roles in gene regulation and cell differentiation. A current debate in the field is if PFs belong to a unique subset of TFs with intrinsic "pioneering activity", or if all TFs have the potential to function as PFs within certain cellular contexts. There are also different views regarding the key feature(s) that define pioneering activity. In this review, we present evidence from the literature related to these alternative views and discuss how to potentially reconcile them. It is possible that both intrinsic properties, like tight nucleosome binding and structural compatibility, and cellular conditions, like concentration and co-factor availability, are important for PF function. [ABSTRACT FROM AUTHOR]

Republic of Learning (RoL) was an experimental program bringing people together to learn about resilience in times of planetary health crisis, environmental change, and growing uncertainty. Eleven sessions took place between 2019 and 2022, planting seeds for an informal community to emerge with a unique approach to shared learning. RoL combined artistic craft-making with cooperative thinking—slowing down debate to sideline confrontations and argument in favor of more gentle forms of colearning and collaboration. This article explores the methods, outcomes, and opportunities that this process opens up for new forms of action and engagement with issues of climate change, resilience, and reciprocity. [ABSTRACT FROM AUTHOR]

Simple Summary: Growth traits have been widely studied as economically important traits in the beef cattle industry. However, traditional studies often miss how these traits change under different environmental conditions, only focusing on single genetic changes that affect traits directly. In our study, we analyzed how genetics and environment interact to affect growth in beef cattle, considering four growth traits and two environmental factors. This analysis uncovered several genetic markers for growth traits that are not usually evident in standard studies, showing that some genes have effects that can be obliterated by environmental conditions Further testing showed whether these genetic markers are grouped in specific genes or functional pathways, helping us understand how genetics can influence growth under different environmental conditions. By uncovering novel genetic loci, genes, and candidate biological mechanisms associated with growth traits, our study provides valuable information for selection prediction and breeding decisions in the beef cattle industry. Complex traits are widely considered to be the result of a compound regulation of genes, environmental factors, and genotype-by-environment interaction (G × E). The inclusion of G × E in genome-wide association analyses is essential to understand animal environmental adaptations and improve the efficiency of breeding decisions. Here, we systematically investigated the G × E of growth traits (including weaning weight, yearling weight, 18-month body weight, and 24-month body weight) with environmental factors (farm and temperature) using genome-wide genotype-by-environment interaction association studies (GWEIS) with a dataset of 1350 cattle. We validated the robust estimator's effectiveness in GWEIS and detected 29 independent interacting SNPs with a significance threshold of 1.67 × 10−6, indicating that these SNPs, which do not show main effects in traditional genome-wide association studies (GWAS), may have non-additive effects across genotypes but are obliterated by environmental means. The gene-based analysis using MAGMA identified three genes that overlapped with the GEWIS results exhibiting G × E, namely SMAD2, PALMD, and MECOM. Further, the results of functional exploration in gene-set analysis revealed the bio-mechanisms of how cattle growth responds to environmental changes, such as mitotic or cytokinesis, fatty acid β-oxidation, neurotransmitter activity, gap junction, and keratan sulfate degradation. This study not only reveals novel genetic loci and underlying mechanisms influencing growth traits but also transforms our understanding of environmental adaptation in beef cattle, thereby paving the way for more targeted and efficient breeding strategies. [ABSTRACT FROM AUTHOR]

Objective: To characterize disease manifestations in Hispanic American patients with systemic sclerosis (SSc) in comparison with non‐Hispanic White and Black patients. Methods: Longitudinal clinical characteristics were collected prospectively in the Genetics versus Environment in Scleroderma Outcome Study cohort. All patients fulfilled the classification criteria for SSc and had a disease duration less than five years at enrollment. Results: A cohort of 427 patients, consisting of 124 Hispanic, 220 non‐Hispanic White, and 83 non‐Hispanic Black participants were examined. At enrollment, Hispanic patients were significantly younger but had longer disease duration, higher frequency of U1‐RNP positivity as well as concurrent systemic lupus erythematosus (SLE) diagnosis, and lower income and educational levels in comparison to non‐Hispanic White patients. Compared with non‐Hispanic Black patients, Hispanic patients had more frequently limited cutaneous involvement and anticentromere antibodies. In the longitudinal analysis, Hispanic patients had significantly lower forced vital capacity percents predicted (point estimate, −9.3%; P < 0.001) than non‐Hispanic White but not Black patients. Hispanic patients had similar longitudinal modified Rodnan Skin Scores like non‐Hispanic White patients but lower measurements than non‐Hispanic Black patients (point estimate, −3.2; P = 0.029). Hispanic patients had significantly higher serially obtained perceived functional disability scores than White patients (point estimate, 0.29; P < 0.001). Hispanic patients also had higher mortality rates than White Americans even after adjustment for age, gender, and socioeconomic statuses. Conclusion: Hispanic patients have higher likelihood of having U1‐RNP positivity and SLE overlap, more severe restrictive lung disease, as well as higher rate of mortality than non‐Hispanic White patients. [ABSTRACT FROM AUTHOR]

Objectives: Hashimoto's thyroiditis (HT) is a common autoimmune disease whose etiology involves a complex interplay between genetics and environment. Previous studies have demonstrated an association between immune cells and HT. However, the casual relationship was not clear. We aimed to explore the causal associations between signatures of immune cells and HT. Methods: In this study, bidirectional two-sample Mendelian randomization (MR) analysis was conducted to investigate the potential causal relationship between 731 immune cell signatures and HT by using genome-wide association study (GWAS) data. Heterogeneity and horizontal pleiotropy were detected through extensive sensitivity analyses. Results: The increased levels of six immune phenotypes were observed to be causally associated with increased risk of HT P < 0.01, which were CD3 on CM CD8br, CD3 on CD39+ secreting Treg, HLA DR on CD33dim HLA DR+ CD11b-, CD3 on CD4 Treg, CD62L-plasmacytoid DC %DC, and CD3 on CD45RA+ CD4+. In addition, the levels of FSC-A on HLA DR+ T cell and CD62L on monocyte were associated with disease risk of HT P < 0.01. In addition, HT also had causal effects on CD3 on CM CD8br, CCR2 on monocyte, CD25 on CD39+ resting Treg, and CCR2 on CD62L+ myeloid DC P < 0.05. Conclusions: In this study, we demonstrated the genetic connection between immune cell traits and HT, thereby providing guidance and direction for future treatment and clinical research. [ABSTRACT FROM AUTHOR]

For many animals, faces are a vitally important visual stimulus. Hence, it is not surprising that face perception has become a very popular research topic in neuroscience, with ca. 2000 papers published every year. As a result, significant progress has been made in understanding the intricate mechanisms underlying this phenomenon. However, the ontogeny of face perception, in particular the role of innate predispositions, remains largely unexplored at the neural level. Several influential studies in monkeys have suggested that seeing faces is necessary for the development of the face-selective brain domains. At the same time, behavioural experiments with newborn human babies and newlyhatched domestic chicks demonstrate that a spontaneous preference towards faces emerges early in life without pre-existing experience. Moreover, we were recently able to record face-selective neural responses in the brain of young, face-naïve chicks, thus demonstrating the existence of an innate face detection mechanism. In this review, we discuss these seemingly contradictory results and propose potential experimental approaches to resolve some of the open questions. [ABSTRACT FROM AUTHOR]

Millets, comprising a diverse group of small‐seeded grains, have emerged as vital crops with immense nutritional, environmental, and economic significance. The comprehension of complex traits in millets, influenced by multifaceted genetic determinants, presents a compelling challenge and opportunity in agricultural research. This review delves into the transformative roles of phenomics and genomics in deciphering these intricate genetic architectures. On the phenomics front, high‐throughput platforms generate rich datasets on plant morphology, physiology, and performance in diverse environments. This data, coupled with field trials and controlled conditions, helps to interpret how the environment interacts with genetics. Genomics provides the underlying blueprint for these complex traits. Genome sequencing and genotyping technologies have illuminated the millet genome landscape, revealing diverse gene pools and evolutionary relationships. Additionally, different omics approaches unveil the intricate information of gene expression, protein function, and metabolite accumulation driving phenotypic expression. This multi‐omics approach is crucial for identifying candidate genes and unfolding the intricate pathways governing complex traits. The review highlights the synergy between phenomics and genomics. Genomically informed phenotyping targets specific traits, reducing the breeding size and cost. Conversely, phenomics identifies promising germplasm for genomic analysis, prioritizing variants with superior performance. This dynamic interplay accelerates breeding programs and facilitates the development of climate‐smart, nutrient‐rich millet varieties and hybrids. In conclusion, this review emphasizes the crucial roles of phenomics and genomics in unlocking the genetic enigma of millets. [ABSTRACT FROM AUTHOR]

Endosymbiotic dinoflagellates (Symbiodiniaceae) influence coral thermal tolerance at both local and regional scales. In isolation, the effects of host genetics, environment, and thermal disturbances on symbiont communities are well understood, yet their combined effects remain poorly resolved. Here, we investigate Symbiodiniaceae across 1300 km in Australia's Coral Sea Marine Park to disentangle these interactive effects. We identified Symbiodiniaceae to species‐level resolution for three coral species (Acropora cf humilis, Pocillopora verrucosa, and Pocillopora meandrina) by sequencing two genetic markers of the symbiont (ITS2 and psbAncr), paired with genotype‐by‐sequencing of the coral host (DArT‐seq). Our samples predominantly returned sequences from the genus Cladocopium, where Acropora cf humilis affiliated with C3k, Pocillopora verrucosa with C. pacificum, and Pocillopora meandrina with C. latusorum. Multivariate analyses revealed that Acropora symbionts were driven strongly by local environment and thermal disturbances. In contrast, Pocillopora symbiont communities were both partitioned 2.5‐fold more by host genetic structure than by environmental structure. Among the two Pocillopora species, the effects of environment and host genetics explained four times more variation in symbionts for P. meandrina than P. verrucosa. The concurrent bleaching event in 2020 had variable impacts on symbiont communities, consistent with patterns in P. verrucosa and A. cf humilis, but not P. meandrina. Our findings demonstrate how symbiont macroscale community structure responses to environmental gradients depend on host species and their respective population structure. Integrating host, symbiont, and environmental data will help forecast the adaptive potential of corals and their symbionts amidst a rapidly changing environment. [ABSTRACT FROM AUTHOR]

The surface [C/N] ratios of evolved giants are strongly affected by the first dredge-up (FDU) of nuclear-processed material from stellar cores. C and N also have distinct nucleosynthetic origins and serve as diagnostics of mixing and mass-loss. We use subgiants to find strong trends in the birth [C/N] with [Fe/H], which differ between the low-α and high-α populations. We demonstrate that these birth trends have a strong impact on the surface abundances after the FDU. This effect is neglected in current stellar models, which use solar-scaled C and N. We map out the FDU as a function of evolutionary state, mass, and composition using a large and precisely measured asteroseismic data set in first-ascent red giant branch (RGB) and core He-burning, or red clump (RC), stars. We describe the domains where [C/N] is a useful mass diagnostic and find that the RC complements the RGB and extends the range of validity to higher mass. We find evidence for extra mixing on the RGB below [Fe/H] = −0.4, matching literature results, for high-α giants, but there is no clear evidence of mixing in the low-α giants. The predicted signal of mass-loss is weak and difficult to detect in our sample. We discuss implications for stellar physics and stellar population applications. [ABSTRACT FROM AUTHOR]

This article considers the novel's possibilities for depicting and responding to the climate crisis by analyzing Richard Powers's efforts to write a biocentric perspective in The Overstory (2018). In biocentric narratives, humans, typically the focal point of the novel, are decentered in favor of perspectives that attempt to encompass more of the living world. Efforts to evade narrative anthropocentrism, which are often encouraged by ecocritics, may not offer an effective frame through which to articulate the climate crisis. The article defends narrative anthropocentrism against the charge that it is unambiguously problematic and challenges the claim that it is potentially avoidable through the adoption of a theoretically biocentric narrative perspective. Rather, strategic awareness of narrative anthropocentrism can help novelists foster visions of strong connections to our environments and inspire reader engagement with environmental concerns. Powers's effort to move beyond anthropocentrism, which is motivated by positive intentions to impact reader interest in environmental issues, is stymied by the inevitability of the human perspectives and interests that attend the construction of any narrative. The article concludes that some instances of anthropocentrism in novels like The Overstory, in which Powers cannot altogether supplant anthropocentrism with a biocentric perspective, are more constructive and positive vis-à-vis nonhuman nature and the environment than others, such as Powers's portrayal of reverence for nonhuman nature. If reverence reveals the attachment of human values and emotions to nonhuman entities, it suggests how anthropocentrism might be harnessed for the benefit of the wider environment. [ABSTRACT FROM AUTHOR]

Popular Hindi cinema in India has come a long way in portraying women. From the 1910s, when male actors used to play heroine characters, to the 1950s, when female actors started playing lead roles, women's depiction has undergone various forms of experimentation. One such aspect constantly discussed in cinema, literature, and other art forms are their depiction of the extremes and their take on the marginalities. This paper attempts to analyse the representation of women in refugee camps in popular Hindi cinema. There are works available focussing on the depiction of women in cinema content-wise. However, the cinematographic portrayal explicitly referring to refugee camps is not widely explored. This paper attempts to fill these existing gaps. It also discusses the current political landscape of India vis-à-vis popular Hindi cinema. The cinematographic representation of women exemplifies their nurturing and caring nature. The screen time shrinks when the focus shifts to their inner conflicts and emotions. [ABSTRACT FROM AUTHOR]

Test weight (TW) is a unit of bulk density that is influenced by several factors, including both genetics and environment. A subset of the trials in the Uniform Soybean Tests—Southern States was used to correlate seed composition traits of oil and protein percentages, and seed weight (SW) with TW to investigate the interaction of these traits in multi‐environments for four different maturity group (MG) tests. The results indicate that environment (location and year combination) had a larger impact on TW than genetic effect in all MG tests. This difference was greater in the earlier MGs, compared to MG VI and MG VII. In all tests across four MGs, the genotype interaction with environment effect was significant, but practically was not as important as genotype or environment effects. Significant negative correlations between TW and SW (MG V, VI, and VII tests), and TW and oil (MG V and VI tests) were observed but not consistent in all environments within these tests. TW and protein correlations were inconsistent with a negative relationship in MG V but a positive relationship in MG VII. As anticipated, the inconsistencies in the relationships across MGs for TW and seed composition traits suggest that selection strategies for improving TW will differ across soybean breeding programs. In the future, a similar study using a diverse panel of cultivars that do not change from year to year may shed more light on the influence of seed composition and environmental conditions on TW. Core Ideas: Soybean test weights are heritable.Test weight and seed trait correlations differ across maturity groups.Test weight values across Uniform Soybean Test—Southern States were lower than the standard 60 lb bu‐1. [ABSTRACT FROM AUTHOR]

A few cases of multiple sclerosis (MS) onset after COVID-19 vaccination have been reported, although the evidence is insufficient to establish causality. The aim of this study is to compare cases of newly diagnosed relapsing–remitting MS before and after the outbreak of the COVID-19 pandemic and the impact of COVID-19 vaccination. Potential environmental and genetic predisposing factors were also investigated, as well as clinical patterns. This is a single-centre retrospective cohort study including all patients who presented with relapsing–remitting MS onset between January 2018 and July 2022. Data on COVID-19 vaccination administration, dose, and type were collected. HLA-DRB1 genotyping was performed in three subgroups. A total of 266 patients received a new diagnosis of relapsing–remitting MS in our centre, 143 before the COVID-19 pandemic (until and including March 2020), and 123 during the COVID-19 era (from April 2020). The mean number of new MS onset cases per year was not different before and during the COVID-19 era and neither were baseline patients' characteristics, type of onset, clinical recovery, or radiological patterns. Fourteen (11.4%) patients who subsequently received a new diagnosis of MS had a history of COVID-19 vaccination within one month before symptoms onset. Patients' characteristics, type of onset, clinical recovery, and radiological patterns did not differ from those of patients with non-vaccine-related new diagnoses of MS. The allele frequencies of HLA-DRB1*15 were 17.6% and 22.2% in patients with non-vaccine-related disease onset before and during the COVID-19 era, respectively, while no case of HLA-DRB1*15 was identified among patients with a new diagnosis of MS post-COVID-19 vaccine. In contrast, HLA-DRB1*08+ or HLA-DRB1*10+ MS patients were present only in this subgroup. Although a causal link between COVID-19 vaccination and relapsing–remitting MS cannot be detected, it is interesting to note and speculate about the peculiarities and heterogeneities underlying disease mechanisms of MS, where the interactions of genetics and the environment could be crucial also for the follow-up and the evaluation of therapeutic options. [ABSTRACT FROM AUTHOR]

The junction of genetics and athleticism reveals a complex interplay that influences a person's sports potential and training response. This investigation digs into the genetic basis of muscle fiber composition, cardiovascular efficiency, and the larger landscape of training adaptation. As genetics takes the front stage in talent discovery and personalized training regimens, privacy permission, and the possibility of discrimination become major focus points. The dynamic interaction of nature and nurture adds dimension to the discussion, emphasizing the varied character of athletic development. The ramifications range from precise training and talent optimization to larger social concerns, necessitating the development of strong regulatory frameworks. Navigating this genetic frontier necessitates a careful balance between releasing our DNA's potential and respecting the ideals of justice, diversity, and ethical practice in sports. In essence, the ramifications of genetics in athletics go beyond individual performance and into ethical, social, and scientific realms. Navigating this complicated terrain demands a concerted effort from athletes, academics, legislators, and the sporting community to maximize potential [ABSTRACT FROM AUTHOR]

TwinsMX registry is a national research initiative in Mexico that aims to understand the complex interplay between genetics and environment in shaping physical and mental health traits among the country's population. With a multidisciplinary approach, TwinsMX aims to advance our knowledge of the genetic and environmental mechanisms underlying ethnic variations in complex traits and diseases, including behavioral, psychometric, anthropometric, metabolic, cardiovascular and mental disorders. With information gathered from over 2800 twins, this article updates the prevalence of several complex traits; and describes the advances and novel ideas we have implemented such as magnetic resonance imaging. The future expansion of the TwinsMX registry will enhance our comprehension of the intricate interplay between genetics and environment in shaping health and disease in the Mexican population. Overall, this report describes the progress in the building of a solid database that will allow the study of complex traits in the Mexican population, valuable not only for our consortium, but also for the worldwide scientific community, by providing new insights of understudied genetically admixed populations. [ABSTRACT FROM AUTHOR]

Zing-Yang Kuo (1898–1970), hailed as China's behaviorist psychologist, earned "Out-Watsons Mr. Watson" in the international anti-instinct movement. His contributions to the field on behavioral neuroembryology (1929–1939) are often overlooked in comparison to his achievements in psychology. We retrieved the titles of all of Kuo's publications from 1929 to 1939 and examined those related to his research on the origins and development of embryonic behavioral ontogeny and the neural basis of embryonic behavior. Remarkably, Kuo concurrently focused on embryos during the same period as North American neuroembryologists. He maintained an independent stance in the debate over the sequence of behavioral ontogeny, represented by the embryonic neuroscientists Coghill and Windle, and critically pointed out limitations in research on both sides of the debate. Drawing from his experiments with chicken embryos, Kuo proposed the theory of behavioral epigenesis, which attempted to end the nature–nurture dichotomy and promote the transformation of the research path of behavioral embryology from elementary physiological anatomy toward a deep "comprehensive science." Kuo's achievements directly laid the foundation for the interdisciplinary field of developmental psychobiology, constructing a new conceptual framework for the systematic analysis of behavioral development and promoting the establishment and development of a new approach to epiphenotype epigenetics. [ABSTRACT FROM AUTHOR]

This study explored the use of an innovative instructional approach called Productive Failure (PF) to design an educational game and its support. The study then examined the effects of two different types of instruction—PF vs. Direct Instruction (DI)—on learning genetics and relevant mathematical knowledge in a Game-Based Learning (GBL) environment. One hundred fifty-seven Year 10 students from two high schools participated in two quasi-experimental studies. The participants were divided into two treatment groups: one group learned targeted concepts using PF with GBL (PF-GBL), while the other group learned the same concepts using DI with GBL (DI-GBL). The results of the first study indicated that the PF-GBL group showed significantly higher learning gains than the DI-GBL group on explanatory genetics knowledge. In the second study, no group difference was found between the PF-GBL group and the DI-GBL group on learning genetics and relevant mathematical knowledge. Implications of findings, limitations, and future research are discussed. [ABSTRACT FROM AUTHOR]

The relationship between people and nature has always been a central theme in literature. Today, especially with environmental problems, it is important to look back at how literature has tackled this theme. Ecocriticism is a way to study literature that focuses on the environment. In other words, it is based on an ecological approach to literary studies and reveals that "human culture is connected to the physical world affecting it and affected by it" (Glotfelty xix). It shows that what we do as humans affects the natural world, and vice versa. This paper, "Nature's Echoes in The Overstory: An Ecocritical Perspective," looks at Richard Powers' The Overstory from an Ecocritical perspective. It breaks down and analyses the characters in this book using the ideas of deep ecology and shallow ecology. This paper also attempts to explore Pope Francis' concepts of 'ecological conversion' and 'integral ecology.' It looks at how the characters in the book go through an 'ecological conversion' that leads them to care about the environment, and how the concept of 'integral ecology' pushes them to connect with nature. Thus, this paper explores these key themes in the novel, showing how human actions seriously affect the natural world. It also talks about the possibility of making a big positive change to have a better relationship with the environment. The goal is to highlight the need for a more sustainable and respectful way of dealing with our planet. [ABSTRACT FROM AUTHOR]

"Human beings spend ten years as little children, and, unable to distinguish between death and life, they spend ten more years holding on to learning... they spends another ten years chasing after gain and acquiring wealth, in order to live on it. They spend another ten years to reach the end of the time, in which their mind has come to skill". Papyrus Insigner, VII, 22-23, XVIII 1-2 (after Paca M.D.2019). In the realm of human development, the term ecopsychology makes the transition from nature to the human being, but especially to the nature of the human being, of their development, taking into account the environment: natural; psychological; social; educational; spiritual; medical; economic; environmental; of origin; of reference, etc., in/to which we find ourselves or wish to find ourselves and which identifies us in this case as a matrix, a personal imprint, giving us the stamp of uniqueness. The environment along with heredity and education has its own social identity and acts as a factor in human development. It represents an accumulation of value where the complex triad: man-nature-society determines its expression as an imprint of human evolution in an informed way, highlighting the formula of social environment. [ABSTRACT FROM AUTHOR]