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Background: Regarding hydatid cyst (cystic echinococcosis, CE) as a human public health problem in the West of Iran, molecular data related to the genotypes of Echinococcus granulosus in cattle and sheep in these regions are still insufficient. Here, we evaluated the genotypes of E. granulosus infecting sheep and cattle in western Iran. Methods: Totally, 36 hydatid cysts including 18 hydatid cysts of sheep and 18 hydatid cysts of cattle were collected from Khorramabad slaughterhouse (Lorestan Province), Western Iran between May to September 2014. Protoscoleces or germinal layers were collected from individual cysts, DNA was extracted, and genotyping was performed by sequencing and analyzing mitochondrial cytochrome c oxidase subunit 1 (cox1) gene. Results: In sequencing analysis, all of sheep isolates belonged to genotype G1 (sheep strain). Among cattle hydatid cyst isolates, 16/18 (88.9%) were belonged to genotype G1 and 2/18 (11.1%) were belonged to G3 genotype. The phylogenetic analysis showed two clusters; one of the clusters includes cattle G3 genotype and the other cluster represents sheep and cattle G1 genotype that were isolated. Conclusion: The common sheep strain/G1 is predominant genotype in the western part of Iran, followed by G3 genotype, circulating among the animal hosts in this region. Further studies covering a larger number of isolates might be necessary to see if there are other genotypes in the hydatid cyst population in this region of Iran. [ABSTRACT FROM AUTHOR]

Background: The aim of this study was to investigate the epidemiological features of colorectal cancer in Imam Reza hospital in Kermanshah, Iran, in a five-year period. Methods: This cross-sectional study included all the patients (N=167) admitted to Imam Reza hospital in Kermanshah over a five-year period, diagnosed with colorectal cancer through performing colonoscopy and confirming via pathology. The census sampling was applied, and the data collection tool was a questionnaire on demographic variables, smoking history, and family history of cancer in immediate relatives. The data were analyzed using the descriptive statistics of frequencies and ratios, and the statistical tests of t-test and chi-square. Results: The mean age of the patients was 58.67±14.31 years old (14-87 years), and 12 % of the patients were under 40 years old. The majority of the patients (52.1%) were males, but no significant difference was found between the two genders in terms of age (P=0.939). The rectum (31.1%), the sigmoid colon (20.4 %), and the ascending colon (18.6%) were the most common tumor sites. Colon adenocarcinoma (96.4%) was the most common reported pathology, 30.5 % of the patients were cigarette smokers, and abdominal pain (22%) was the most common complaint on admission. Conclusion: Given the results of the present study, it is highly recommended that comprehensive studies should be conducted on screening colorectal cancer in high risk populations in order to reduce the incidence and prevalence of the disease and treat it more effectively based on early diagnosis. [ABSTRACT FROM AUTHOR]