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1. Achievement of guideline-recommended target blood pressure is associated with reducing the risk of hemorrhagic and ischemic stroke in Japanese coronary artery disease patients -the CLIDAS study-

Author

Oba, Yusuke, Kabutoya, Tomoyuki, Kohro, Takahide, Imai, Yasushi, Kario, Kazuomi, Sato, Hisahiko, Nochioka, Kotaro, Nakayama, Masaharu, Akashi, Naoyuki, Fujita, Hideo, Mizuno, Yoshiko, Kiyosue, Arihiro, Iwai, Takamasa, Miyamoto, Yoshihiro, Nakano, Yasuhiro, Ishii, Masanobu, Nakamura, Taishi, Tsujita, Kenichi, Matoba, Tetsuya, and Nagai, Ryozo

Published
2024
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7. Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis

Author

Sinha, Sonal, Aizawa, Satoka, Nakano, Yasuhiro, Rialdi, Alexander, Choi, Hye Yeon, Shrestha, Rajan, Pan, Stephanie Q., Chen, Yibu, Li, Meng, Kapelanski-Lamoureux, Audrey, Yochum, Gregory, Sher, Linda, Monga, Satdarshan Paul, Lazaris, Anthoula, Machida, Keigo, Karin, Michael, Guccione, Ernesto, and Tsukamoto, Hidekazu

Published
2023
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8. Phase-dependent trends in the prevalence of myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) related to long COVID: A criteria-based retrospective study in Japan.

Author

Morita, Satoru, Tokumasu, Kazuki, Otsuka, Yuki, Honda, Hiroyuki, Nakano, Yasuhiro, Sunada, Naruhiko, Sakurada, Yasue, Matsuda, Yui, Soejima, Yoshiaki, Ueda, Keigo, and Otsuka, Fumio

Abstract

Background: The characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) related to COVID-19 have remained uncertain. To elucidate the clinical trend of ME/CFS induced by long COVID, we examined data for patients who visited our outpatient clinic established in a university hospital during the period from Feb 2021 to July 2023. Methods: Long COVID patients were classified into two groups, an ME/CFS group and a non-ME/CFS group, based on three diagnostic criteria. Results: The prevalence of ME/CFS in the long COVID patients was 8.4% (62 of 739 cases; female: 51.6%) and factors related to ME/CFS were severe illness, smoking and alcohol drinking habits, and fewer vaccinations. The frequency of ME/CFS decreased from 23.9% in the Preceding period to 13.7% in the Delta-dominant period and to 3.3% in the Omicron-dominant period. Fatigue and headache were commonly frequent complaints in the ME/CFS group, and the frequency of poor concentration in the ME/CFS group was higher in the Omicron period. Serum ferritin levels were significantly higher in female patients in the ME/CFS group infected in the Preceding period. In the ME/CFS group, the proportion of patients complaining of brain fog significantly increased from 22.2% in the Preceding period to 47.9% in the Delta period and to 81.3% in the Omicron period. The percentage of patients who had received vaccination was lower in the ME/CFS group than the non-ME/CFS group over the study period, whereas there were no differences in the vaccination rate between the groups in each period. Conclusion: The proportion of long COVID patients who developed ME/CFS strictly diagnosed by three criteria was lower among patients infected in the Omicron phase than among patients infected in the other phases, while the proportion of patients with brain fog inversely increased. Attention should be paid to the variant-dependent trends of ME/CFS triggered by long COVID (300 words). [ABSTRACT FROM AUTHOR]

Published
2024
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9. Early-stage antibody kinetics after the third dose of BNT162b2 mRNA COVID-19 vaccination measured by a point-of-care fingertip whole blood testing

Author

Hagiya, Hideharu, Nakano, Yasuhiro, Furukawa, Masanori, Sunada, Naruhiko, Hasegawa, Toru, Sakurada, Yasue, Hasegawa, Kou, Yamamoto, Koichiro, Ogawa, Hiroko, Obara, Takafumi, Ageta, Kouhei, Matsumoto, Naomi, Matsuo, Rumi, Kadowaki, Tomoka, Higashikage, Akihito, Hikita, Takao, Yorifuji, Takashi, Toyooka, Shinichi, Maeda, Yoshinobu, Yokokura, Yoshinori, Otsuka, Fumio, and Nakayama, Masanori

Published
2022
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13. Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on the Severity and the Mortality of Acute Myocardial Infarction in Japan — Analysis From the JROAD-DPC Database —

Author

Kimura, Mitsukuni, primary, Matoba, Tetsuya, additional, Nakano, Yasuhiro, additional, Katsuki, Shunsuke, additional, Sakamoto, Kazuo, additional, Nishihara, Masaaki, additional, Nagata, Takuya, additional, Tahara, Yoshio, additional, Nagao, Ken, additional, Okura, Hiroyuki, additional, Ikeda, Takanori, additional, Nakai, Michikazu, additional, and Tsutsui, Hiroyuki, additional

Published
2024
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15. Associations among plasma concentrations of regorafenib and its metabolites, adverse events, and ABCG2 polymorphisms in patients with metastatic colorectal cancers

Author

Kobayashi, Kazuo, Sugiyama, Erika, Shinozaki, Eiji, Wakatsuki, Takeru, Tajima, Masataka, Kidokoro, Hiyori, Aoyama, Takeshi, Nakano, Yasuhiro, Kawakami, Kazuyoshi, Hashimoto, Koki, Suenaga, Mitsukuni, Ichimura, Takashi, Ogura, Mariko, Chin, Keisho, Nakayama, Izuma, Ooki, Akira, Takahari, Daisuke, Suzuki, Wataru, Yokokawa, Takashi, Minowa, Yuichi, Hiraoka, Tomoko, Suzuki, Kenichi, Sato, Hitoshi, Hama, Toshihiro, and Yamaguchi, Kensei

Published
2021
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16. Importance of Blood Glucose Measurement for Predicting the Prognosis of Long COVID: A Retrospective Study in Japan.

Author

Yokoyama, Sho, Honda, Hiroyuki, Otsuka, Yuki, Tokumasu, Kazuki, Nakano, Yasuhiro, Sakurada, Yasue, Matsuda, Yui, Sunada, Naruhiko, Hasegawa, Toru, Takase, Ryosuke, Omura, Daisuke, Soejima, Yoshiaki, Ueda, Keigo, Kishida, Masayuki, and Otsuka, Fumio

Subjects
POST-acute COVID-19 syndrome, SARS-CoV-2 Omicron variant, BLOOD sugar measurement, ALCOHOL drinking, BLOOD sugar
Abstract

Purpose: The present study aimed to clarify the effects of a hyperglycemic condition on the clinical consequences of long COVID. Methods: Among 643 patients who visited the outpatient clinic of our hospital from February 2021 to September 2023, long COVID patients were classified into a hyperglycemic (HG) group with casual blood glucose levels above 140 mg/dL and a normoglycemic (NG) group. The patients' backgrounds, clinical symptoms, health status including the QOL evaluation scale (EQ-5D-5L), self-rating depression scale (SDS), and F-scale questionnaire (FSSG), blood test data, and recovery periods were analyzed. Results: The NG group included 607 patients with long COVID and the HG group included 36 patients with long COVID. Patients in the HG group were older than those in the NG group (55 vs. 41 years; p < 0.001) and included a larger percentage of males (67% vs. 44%; p = 0.009). The HG group had a larger percentage of patients with moderate-to-severe conditions in the acute infection phase (28% vs. 12%; p = 0.008), a higher BMI (25 vs. 22 kg/m2; p < 0.001), higher blood pressure (138/81 vs. 122/72 mmHg; p < 0.001), and a larger percentage of patients with an alcohol drinking habit (53% vs. 34%; p = 0.031). Long COVID symptoms and self-rated scales were not differed between the two groups; however, the laboratory data showed that liver and renal functions and metabolic data were significantly worse in the HG group. Although there was no apparent difference between the two groups in duration from the infection to the first visit, the HG group had a significantly longer period of recovery from long COVID (median period of 421 vs. 294 days; p = 0.019). Conclusion: A hyperglycemic state associated with other lifestyle-related diseases is associated with the prolongation of recovery from long COVID. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

Author

Omori, Satotaka, Wang, Teh-Wei, Johmura, Yoshikazu, Kanai, Tomomi, Nakano, Yasuhiro, Kido, Taketomo, Susaki, Etsuo A., Nakajima, Takuya, Shichino, Shigeyuki, Ueha, Satoshi, Ozawa, Manabu, Yokote, Kisho, Kumamoto, Soichiro, Nishiyama, Atsuya, Sakamoto, Takeharu, Yamaguchi, Kiyoshi, Hatakeyama, Seira, Shimizu, Eigo, Katayama, Kotoe, Yamada, Yasuhiro, Yamazaki, Satoshi, Iwasaki, Kanako, Miyoshi, Chika, Funato, Hiromasa, Yanagisawa, Masashi, Ueno, Hiroo, Imoto, Seiya, Furukawa, Yoichi, Yoshida, Nobuaki, Matsushima, Kouji, Ueda, Hiroki R., Miyajima, Atsushi, and Nakanishi, Makoto

Published
2020
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21. Overview of the 87th Annual Scientific Meeting of the Japanese Circulation Society (JCS2023) ― New Challenge With Next Generation ―

Author

Matoba, Tetsuya, primary, Nakano, Yasuhiro, additional, Katsuki, Shunsuke, additional, Ide, Tomomi, additional, Matsushima, Shouji, additional, Fujino, Takeo, additional, Hashimoto, Toru, additional, Shinohara, Keisuke, additional, Abe, Kohtaro, additional, Hosokawa, Kazuya, additional, Sakamoto, Takafumi, additional, Sakamoto, Ichiro, additional, Kakino, Takamori, additional, Ishikita, Ayako, additional, Nishizaki, Akiko, additional, Sakamoto, Kazuo, additional, Takase, Susumu, additional, Nagayama, Tomomi, additional, Tohyama, Takeshi, additional, Nagata, Takuya, additional, Kinugawa, Shintaro, additional, and Tsutsui, Hiroyuki, additional

Published
2024
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23. On Constructing Constrained Tree Automata Recognizing Ground Instances of Constrained Terms

Author

Nishida, Naoki, Sakai, Masahiko, and Nakano, Yasuhiro

Subjects
Computer Science - Formal Languages and Automata Theory, Computer Science - Logic in Computer Science, F.1.1 Automata
Abstract

An inductive theorem proving method for constrained term rewriting systems, which is based on rewriting induction, needs a decision procedure for reduction-completeness of constrained terms. In addition, the sufficient complete property of constrained term rewriting systems enables us to relax the side conditions of some inference rules in the proving method. These two properties can be reduced to intersection emptiness problems related to sets of ground instances for constrained terms. This paper proposes a method to construct deterministic, complete, and constraint-complete constrained tree automata recognizing ground instances of constrained terms., Comment: In Proceedings TTATT 2013, arXiv:1311.5058

Published
2013
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25. “LIPID PARADOX” IN JAPANESE HYPERTRIGLYCERIDEMIA PATIENTS UNDERGOING PCI IN CLIDAS

Author

Kimura, Mitsukuni, Katsuki, Shunsuke, Nakano, Yasuhiro, Kawahara, Takuro, Hino, Rissei, Tabuchi, Takuya, Fukata, Mitsuhiro, Hieda, Michinari, Kohro, Takahide, Kabutoya, Tomoyuki, Makimoto, Hisaki, Kario, Kazuomi, Imai, Yasushi, Fujita, Hideo, Kodera, Satoshi, Kiyosue, Arihiro, Nakayama, Masaharu, Miyamoto, Yoshihiro, Tsujita, Kenichi, Sato, Hisahiko, Nagai, Ryozo, and Matoba, Tetsuya

Published
2024
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26. Characteristics of Persistent Symptoms Manifested after SARS-CoV-2 Vaccination: An Observational Retrospective Study in a Specialized Clinic for Vaccination-Related Adverse Events

Author

Tokumasu, Kazuki, primary, Fujita-Yamashita, Manami, additional, Sunada, Naruhiko, additional, Sakurada, Yasue, additional, Yamamoto, Koichiro, additional, Nakano, Yasuhiro, additional, Matsuda, Yui, additional, Otsuka, Yuki, additional, Hasegawa, Toru, additional, Hagiya, Hideharu, additional, Honda, Hiroyuki, additional, and Otsuka, Fumio, additional

Published
2023
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28. JCS/CVIT/JCC 2023 guideline focused update on diagnosis and treatment of vasospastic angina (coronary spastic angina) and coronary microvascular dysfunction

Author

Hokimoto, Seiji, primary, Kaikita, Koichi, additional, Yasuda, Satoshi, additional, Tsujita, Kenichi, additional, Ishihara, Masaharu, additional, Matoba, Tetsuya, additional, Matsuzawa, Yasushi, additional, Mitsutake, Yoshiaki, additional, Mitani, Yoshihide, additional, Murohara, Toyoaki, additional, Noda, Takashi, additional, Node, Koichi, additional, Noguchi, Teruo, additional, Suzuki, Hiroshi, additional, Takahashi, Jun, additional, Tanabe, Yasuhiko, additional, Tanaka, Atsushi, additional, Tanaka, Nobuhiro, additional, Teragawa, Hiroki, additional, Yasu, Takanori, additional, Yoshimura, Michihiro, additional, Asaumi, Yasuhide, additional, Godo, Shigeo, additional, Ikenaga, Hiroki, additional, Imanaka, Takahiro, additional, Ishibashi, Kohei, additional, Ishii, Masanobu, additional, Ishihara, Takayuki, additional, Matsuura, Yunosuke, additional, Miura, Hiroyuki, additional, Nakano, Yasuhiro, additional, Ogawa, Takayuki, additional, Shiroto, Takashi, additional, Soejima, Hirofumi, additional, Takagi, Ryu, additional, Tanaka, Akihito, additional, Taruya, Akira, additional, Tsuda, Etsuko, additional, Wakabayashi, Kohei, additional, Yokoi, Kensuke, additional, Minamino, Toru, additional, Nakagawa, Yoshihisa, additional, Sueda, Shozo, additional, Shimokawa, Hiroaki, additional, and Ogawa, Hisao, additional

Published
2023
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29. THU116 Characteristics Of Sleep Disturbance And The Related Hormonal Changes In Patients With Long COVID

Author

Sunada, Naruhiko, primary, Nakano, Yasuhiro, additional, Otsuka, Yuki, additional, Tokumasu, Kazuki, additional, Honda, Hiroyuki, additional, Sakurada, Yasue, additional, Matsuda, Yui, additional, Hasegawa, Toru, additional, Omura, Daisuke, additional, Ochi, Kanako, additional, Hagiya, Hideharu, additional, Ueda, Keigo, additional, Kataoka, Hitomi, additional, and Otsuka, Fumio, additional

Published
2023
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31. THU581 Possible Markers For Myalgic Encephalomyelitis / Chronic Fatigue Syndrome Developed In Long Covid: Utility Of Serum Ferritin And Insulin-like Growth Factor-I

Author

Yamamoto, Yukichika, primary, Otsuka, Yuki, additional, Tokumasu, Kazuki, additional, Sunada, Naruhiko, additional, Nakano, Yasuhiro, additional, Honda, Hiroyuki, additional, Sakurada, Yasue, additional, Hasegawa, Toru, additional, Hagiya, Hideharu, additional, and Otsuka, Fumio, additional

Published
2023
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34. Protocol for the ASTRO study (SSOP-01): a multicentre prospective cohort study investigating adverse events based on electronic patient-reported outcomes in patients with breast cancer after adjuvant chemotherapy

Author

Kuniyoshi, Ouki, primary, Sano, Motohiko, additional, Nakano, Yasuhiro, additional, Kawaguchi, Takashi, additional, Hatakeyama, Tomoki, additional, Tsuchiya, Yusuke, additional, Inada, Yusuke, additional, Harada, Tomohiko, additional, Kurosaki, Miyuki, additional, Mashiko, Tomoe, additional, Miyaji, Tempei, additional, and Yamaguchi, Takuhiro, additional

Published
2023
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36. Association between Serum Oxysterols and Coronary Plaque Regression during Lipid-Lowering Therapy with Statin and Ezetimibe: Insights from the CuVIC Trial

Author

Nakano, Yasuhiro, primary, Yamamoto, Mitsutaka, additional, Matoba, Tetsuya, additional, Katsuki, Shunsuke, additional, Nakashiro, Soichi, additional, Takase, Susumu, additional, Akiyama, Yusuke, additional, Nagata, Takuya, additional, Mukai, Yasushi, additional, Inoue, Shujiro, additional, Oi, Keiji, additional, Higo, Taiki, additional, Takemoto, Masao, additional, Suematsu, Nobuhiro, additional, Eshima, Kenichi, additional, Miyata, Kenji, additional, Usui, Makoto, additional, Sadamatsu, Kenji, additional, Kadokami, Toshiaki, additional, Hironaga, Kiyoshi, additional, Ichi, Ikuyo, additional, Todaka, Koji, additional, Kishimoto, Junji, additional, and Tsutsui, Hiroyuki, additional

Published
2023
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40. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells.

Author

Soejima, Yoshiaki, Iwata, Nahoko, Yamamoto, Koichiro, Suyama, Atsuhito, Nakano, Yasuhiro, and Otsuka, Fumio

Subjects
BONE morphogenetic proteins, OREXINS, TYROSINE hydroxylase, CENTRAL nervous system, ADRENAL glands
Abstract

Orexins are neuronal peptides that play a prominent role in sleep behavior and feeding behavior in the central nervous system, though their receptors also exist in peripheral organs, including the adrenal gland. In this study, the effects of orexins on catecholamine synthesis in the rat adrenomedullary cell line PC12 were investigated by focusing on their interaction with the adrenomedullary bone morphogenetic protein (BMP)-4. Orexin A treatment reduced the mRNA levels of key enzymes for catecholamine synthesis, including tyrosine hydroxylase (Th), 3,4-dihydroxyphenylalanie decarboxylase (Ddc) and dopamine β-hydroxylase (Dbh), in a concentration-dependent manner. On the other hand, treatment with BMP-4 suppressed the expression of Th and Ddc but enhanced that of Dbh with or without co-treatment with orexin A. Of note, orexin A augmented BMP-receptor signaling detected by the phosphorylation of Smad1/5/9 through the suppression of inhibitory Smad6/7 and the upregulation of BMP type-II receptor (BMPRII). Furthermore, treatment with BMP-4 upregulated the mRNA levels of OX1R in PC12 cells. Collectively, the results indicate that orexin and BMP-4 suppress adrenomedullary catecholamine synthesis by mutually upregulating the pathway of each other in adrenomedullary cells. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Association of Serum Oxysterols with Cholesterol Metabolism Markers and Clinical Factors in Patients with Coronary Artery Disease: A Covariance Structure Analysis

Author

Akiyama, Yusuke, primary, Katsuki, Shunsuke, additional, Matoba, Tetsuya, additional, Nakano, Yasuhiro, additional, Takase, Susumu, additional, Nakashiro, Soichi, additional, Yamamoto, Mitsutaka, additional, Mukai, Yasushi, additional, Inoue, Shujiro, additional, Oi, Keiji, additional, Higo, Taiki, additional, Takemoto, Masao, additional, Suematsu, Nobuhiro, additional, Eshima, Kenichi, additional, Miyata, Kenji, additional, Usui, Makoto, additional, Sadamatsu, Kenji, additional, Kadokami, Toshiaki, additional, Hironaga, Kiyoshi, additional, Ichi, Ikuyo, additional, Todaka, Koji, additional, Kishimoto, Junji, additional, and Tsutsui, Hiroyuki, additional

Published
2023
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45. Trends in Long COVID Symptoms in Japanese Teenage Patients

Author

Sakurada, Yasue, Otsuka, Yuki, Tokumasu, Kazuki, Sunada, Naruhiko, Honda, Hiroyuki, Nakano, Yasuhiro, Matsuda, Yui, Hasegawa, Toru, Ochi, Kanako, Hagiya, Hideharu, Ueda, Keigo, Kataoka, Hitomi, Otsuka, Fumio, Sakurada, Yasue, Otsuka, Yuki, Tokumasu, Kazuki, Sunada, Naruhiko, Honda, Hiroyuki, Nakano, Yasuhiro, Matsuda, Yui, Hasegawa, Toru, Ochi, Kanako, Hagiya, Hideharu, Ueda, Keigo, Kataoka, Hitomi, and Otsuka, Fumio

Abstract

Background: Since the start of the global pandemic of coronavirus disease 2019 (COVID-19), not only adults but also many children have suffered from it. However, the clinical characteristics of long COVID in children remain unclear. Methods: In this retrospective observational study conducted in a single facility, we reviewed the medical records of all long COVID patients who visited Okayama University Hospital from February 2021 to October 2022, and we compared the clinical characteristics of long COVID in teenagers (11 to 18 years of age) with those in adults. Results: Data for 452 long COVID patients including 54 teenagers (11.9%) were analyzed. Fatigue was the most frequent symptom in teenagers (55.6% of the patients) and also in adults. On the other hand, the percentage of teenagers who complained of headache, which was the second most frequent complaint, was significantly higher than the percentage of adults (35.2% vs. 21.9%, p < 0.05). A comparison of the frequencies of symptoms depending on the viral variant showed that fatigue and headache were predominant symptoms in the Omicron variant phase. Of the 50 teenagers who were enrolled in schools, 28 (56.0%) could not attend school due to long COVID symptoms. The most common symptoms as reasons for absence from school were fatigue (85.7% of the patients), headache (42.9%), and insomnia (32.1%). Conclusions: Attention should be paid to the symptoms of fatigue and headache in teenagers with long COVID.

Published
2023

46. Symptomatic Characteristics of Hypozincemia Detected in Long COVID Patients

Author

Matsuda, Yui, Tokumasu, Kazuki, Otsuka, Yuki, Sunada, Naruhiko, Honda, Hiroyuki, Sakurada, Yasue, Nakano, Yasuhiro, Hasegawa, Toru, Obika, Mikako, Ueda, Keigo, Otsuka, Fumio, Matsuda, Yui, Tokumasu, Kazuki, Otsuka, Yuki, Sunada, Naruhiko, Honda, Hiroyuki, Sakurada, Yasue, Nakano, Yasuhiro, Hasegawa, Toru, Obika, Mikako, Ueda, Keigo, and Otsuka, Fumio

Abstract

Objectives: The aim of this study was to determine the characteristics of hypozincemia in long COVID patients. Methods: This study was a single-center retrospective observational study for outpatients who visited the long COVID clinic established in a university hospital during the period from 15 February 2021 to 28 February 2022. Characteristics of patients with a serum zinc concentration lower than 70 mu g/dL (10.7 mu mol/L) were compared with characteristics of patients with normozincemia. Results: In a total of 194 patients with long COVID after excluding 32 patients, hypozincemia was detected in 43 patients (22.2%) including 16 male patients (37.2%) and 27 female patients (62.8%). Among various parameters including the background characteristics of the patients and medical histories, the patients with hypozincemia were significantly older than the patients with normozincemia (median age: 50 vs. 39 years). A significant negative correlation was found between serum zinc concentrations and age in male patients (R = -0.39; p < 0.01) but not in female patients. In addition, there was no significant correlation between serum zinc levels and inflammatory markers. General fatigue was the most frequent symptom in both male patients with hypozincemia (9 out of 16: 56.3%) and female patients with hypozincemia (8 out of 27: 29.6%). Patients with severe hypozincemia (serum zinc level lower than 60 mu g/dL) had major complaints of dysosmia and dysgeusia, which were more frequent complaints than general fatigue. Conclusions: The most frequent symptom in long COVID patients with hypozincemia was general fatigue. Serum zinc levels should be measured in long COVID patients with general fatigue, particularly in male patients.

Published
2023

47. Manifestation of Headache Affecting Quality of Life in Long COVID Patients

Author

Fujita, Kana, Otsuka, Yuki, Sunada, Naruhiko, Honda, Hiroyuki, Tokumasu, Kazuki, Nakano, Yasuhiro, Sakurada, Yasue, Obika, Mikako, Hagiya, Hideharu, Otsuka, Fumio, Fujita, Kana, Otsuka, Yuki, Sunada, Naruhiko, Honda, Hiroyuki, Tokumasu, Kazuki, Nakano, Yasuhiro, Sakurada, Yasue, Obika, Mikako, Hagiya, Hideharu, and Otsuka, Fumio

Abstract

Objectives: The present study aimed to elucidate the characteristics of long COVID patients with headaches. Methods: A single-center retrospective observational study was performed for long COVID outpatients who visited our hospital from 12 February 2021 to 30 November 2022. Results: A total of 482 long COVID patients, after excluding 6, were divided into two groups: the Headache group of patients with complaints of headache (113 patients: 23.4%) and the remaining Headache-free group. Patients in the Headache group were younger (median age: 37 years) than patients in the Headache-free group (42 years), while the ratio of females (56%) in the Headache group was nearly the same as that in the Headache-free group (54%). The proportion of patients in the Headache group who were infected in the Omicron-dominant phase (61%) was larger than the proportions of patients infected in the Delta (24%) and preceding (15%) phases, and that trend was significantly different from the trend in the Headache-free group. The duration before the first visit for long COVID was shorter in the Headache group (71 days) than in the Headache-free group (84 days). The proportions of patients in the Headache group with comorbid symptoms, including general fatigue (76.1%), insomnia (36.3%), dizziness (16.8%), fever (9.7%), and chest pain (5.3%) were larger than the proportions of patients in the Headache-free group, whereas blood biochemical data were not significantly different between the two groups. Interestingly, patients in the Headache group had significant deteriorations of scores indicating depression and scores for quality of life and general fatigue. In multivariate analysis, headache, insomnia, dizziness, lethargy, and numbness were shown to be involved in the quality of life (QOL) of long COVID patients. Conclusions: The manifestation of headaches related to long COVID was found to have a significant impact on social and psychological activities. Alleviation of headaches should be a p

Published
2023

48. Interaction of Orexin and Bone Morphogenetic Proteins in Steroidogenesis by Human Adrenocortical Cells

Author

Soejima, Yoshiaki, Iwata, Nahoko, Nishioka, Ran, Honda, Mako, Nakano, Yasuhiro, Yamamoto, Koichiro, Suyama, Atsuhito, Otsuka, Fumio, Soejima, Yoshiaki, Iwata, Nahoko, Nishioka, Ran, Honda, Mako, Nakano, Yasuhiro, Yamamoto, Koichiro, Suyama, Atsuhito, and Otsuka, Fumio

Abstract

Orexins are neuropeptides that play important roles in sleep-wake regulation and food intake in the central nervous system, but their receptors are also expressed in peripheral tissues, including the endocrine system. In the present study, we investigated the functions of orexin in adrenal steroidogenesis using human adrenocortical H295R cells by focusing on its interaction with adrenocortical bone morphogenetic proteins (BMPs) that induce adrenocortical steroidogenesis. Treatment with orexin A increased the mRNA levels of steroidogenic enzymes including StAR, CYP11B2, CYP17, and HSD3B1, and these effects of orexin A were further enhanced in the presence of forskolin. Interestingly, orexin A treatment suppressed the BMP-receptor signaling detected by Smad1/5/9 phosphorylation and Id-1 expression through upregulation of inhibitory Smad7. Orexin A also suppressed endogenous BMP-6 expression but increased the expression of the type-II receptor of ActRII in H295R cells. Moreover, treatment with BMP-6 downregulated the mRNA level of OX1R, but not that of OX2R, expressed in H295R cells. In conclusion, the results indicate that both orexin and BMP-6 accelerate adrenocortical steroidogenesis in human adrenocortical cells; both pathways mutually inhibit each other, thereby leading to a fine-tuning of adrenocortical steroidogenesis.

Published
2023

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