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19 results on '"NAGHIZADEH, Farzaneh"'

18. High Magnification in vivoEvaluation of the Mechanism of Failure of An Ex-PRESS Shunt Implanted Under the Sclera Flap

Author

Holló, Gábor and Naghizadeh, Farzaneh

Abstract

Purpose To investigate the mechanism of fibrosis-related failure of an Ex-PRESS shunt implanted under the scleral flap in trabeculectomy.Methods Case report.Results A patient with end-stage secondary open-angle glaucoma on his only functioning right eye was referred for glaucoma valve implantation. His right eye had undergone congenital cataract surgery in early childhood and posterior chamber lens implantation 20 years ago. During the last 18 months, the right eye underwent pars plana vitrectomy with silicone oil implantation, silicone oil removal, 2 sessions of cyclophotocoagulation, 2 failed trabeculectomies (one of them combined with Ex-PRESS shunt implantation under the scleral flap), and 4 trabeculectomy revisions. At presentation, the intraocular pressure varied between 47 and 52 mm Hg on maximal systemic and topical intraocular pressure–lowering medication. Serial limbus parallel scans made with the CAM-L cornea lens adapter of the Optovue Fourier-domain optical coherence tomograph revealed that the space between the inner surface of the scleral flap and the external orifice of the Ex-PRESS shunt was filled by scar tissue, and the scar tissue appeared to invade the lumen of the shunt.Conclusions The findings suggest that failure of an Ex-PRESS shunt is not always caused by episcleral fibrosis but may also be caused by scar formation between the scleral flap and the implant, inside the surgical sclera tunnel.

Published
2014
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19. [Retinal ganglion cell layer and visual function in patients with progressive external ophthalmoplegia caused by common mtDNA deletion].

Author

Naghizadeh F, Varga ET, Molnár MJ, and Holló G

Subjects
Adult, Evoked Potentials, Visual, Female, Humans, Middle Aged, Ophthalmoplegia, Chronic Progressive External complications, Ophthalmoplegia, Chronic Progressive External genetics, Scanning Laser Polarimetry, Severity of Illness Index, Tomography, Optical Coherence, Vision Disorders pathology, Vision Disorders physiopathology, Vision, Ocular, DNA, Mitochondrial, Gene Deletion, Ophthalmoplegia, Chronic Progressive External pathology, Ophthalmoplegia, Chronic Progressive External physiopathology, Retinal Ganglion Cells pathology, Vision Disorders etiology
Abstract

Aim: Mitochondrial (mt) disorders are metabolic conditions with multiorgan involvement, which often cause neuroophtalmological symptoms. The aim of the study was to investigate the relation between progressive external ophthalmoplegia (PEO), visual pathway and mitochondrial DNA (mtDNA) mutations in patients younger than 55 years of age., Methods: Five female patients (35 to 53 years of age) with mithochondrial disease were investigated. Automated threshold perimetry (Octopus G2 test), scanning laser polarimetry (GDx-VCC and GDx-ECC) and Fourier-domain optical coherence tomography (RTVue-100 OCT) were used in addition to detailed ophthalmological examination and evaluation of visually evoked potentials (VEP). Frequent mutations of the mtDNA were investigated in the patients' blood and muscle samples., Results: PEO of various severity levels was found in all patients, using clinical tests. Genetic testing showed "common deletion" of mtDNA in all cases. For both eyes of 4 patients functional and structural ophthalmic tests had normal results. In one patient decreased visual acuity, reduced retinal nerve fiber layer thickness and prolonged L3 VEP latency time were found without optic disc damage and visual field deterioration., Conclusion: In 4 of our 5 patients with PEO due to common deletion of mtDNA retinal ganglion cells and visual function remained normal for a long period of life.

Published
2014

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