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To align with the SDG 12.3 target and ensure global food security and sustainability, it is crucial to prioritize the reduction of food loss and waste. This paper aims to synthesize previous research on waste reduction tools like lean manufacturing in the agro-food processing industry and identify areas that require further investigation to assurance worldwide food security and promote sustainability. The study uses a systematic literature review that was proposed by Denyer and Tranfield. This research work provides a descriptive analysis of the evolution of lean manufacturing in agro-food processing and identifies research gaps. The review highlights the importance of demand forecasting, managing variable raw materials and products, increasing management involvement, promoting partnership among supply chain members, and addressing supply and demand seasonality and uncertainty to apply the approach to food waste reduction. Based on the findings, the paper suggests further research areas for future investigation that will help create a more sustainable and equitable food system. Reducing food loss and waste can ensure that everyone has access to safe, nutritious, and affordable food while protecting the planet's resources and reducing greenhouse gas emissions. This study may contribute to the theory of waste minimization, specifically in post-harvest food loss and waste minimization. The findings will help researchers conduct research work interested in minimizing food loss and waste to ensure global food security.