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The paper presents the results of a ten-year (2008–2017) analysis of morbidity, prevalence of chronic cystitis among both sexes of the adult population of the Western region in terms of regions, as well as in terms of all-Ukrainian data. The primary material was the official statistical reports of medical institutions of the Ministry of Health of Ukraine. Two five-year periods were allocated to clarify the dynamics and nature of its changes. It was found that in contrast to the increase in registered patients in Ukraine as a whole at the expense of women, in the region there is a steady decrease in both women and men with a stable preservation of third place in the overall structure. The number of newly diagnosed patients in the region increased by 5.4% in 2013–2017 (by 11.6 and 5,7% among women and men, respectively), while in Ukraine by 2.1% only among women (by 12.4%) to 2992 and 15112 in 2017, respectively. Interregional peculiarities in the region have been traced and it has been established that the situation in it is formed by Lviv, Ivano-Frankivsk and Chernivtsi regions. The nature of changes in absolute values †and intensity is similar.

The paper presents the results of the analysis for 2008–2017 of the prevalence and incidence of chronic cystitis in the adult population of Kiev based on the data of state, sectoral statistical reports (F.F. No. 12, 20). Two five-year periods are highlighted, the justification for which was the well-known territorial changes in the country; the corresponding indicators served as a comparison, which made it possible to identify the features of the dynamics of the studied processes. As a result of 10 years of observation, it was revealed that for the city of Kiev, which ranks second in the structure of the prevalence and incidence of chronic cystitis in Ukraine, a decrease in the number of registered patients (by 7.3%) with a simultaneous increase in newly diagnosed patients (by 15.6%; by 25.6% of men and 13.2% of women), in contrast to their overall growth in the country as a whole (by 0.4% and 2.8%, respectively). Prevalence rates (per 100 thousand) after an increase in the first five years are replaced by a decrease in the next period (621.2 to 687.9 versus 627.8 to 533.4). Among women, they were 3.5-4.8 times large; in 2017 – 862.8 versus 176.6 among men. The peculiarity of the incidence was manifested by its increase among women and men in 2013–2017 against the background of a decrease in the previous years; in 2017, the indicators per 100 thousand reached 88.5; among women – 127.2, men – 41.5. The observed situation of an increase in the incidence of chronic cystitis among the adult population of the capital with a simultaneous decrease in the prevalence allows us to evaluate it as a result of the provided adequate specialized care and, at the same time, indicates the need to study the causes, negative factors, as the basis for the improvement and implementation of disease prevention.

The work is based on the materials of official statistical reporting, the analysis of which was carried out for 10 years, divided into two five-year periods (2009-2013 and 2014-2018). Absolute and intensive rates of morbidity and distribution of bladder cancer of the adult population of Ukraine in the regional aspect, taking into account sex were studied, the basic indicators of the prevalence of pathology were analyzed as well. The revealed unfavorable situation is characterized by a steady increase in morbidity and prevalence at a slower pace during 2014-2018. It is noteworthy the high level of morbidity in men, which is growing against the background of its stabilization among women. At the same time, there was noted the tendency in the reduced number of newly diagnosed patients during professional examinations (in 2018-16.9% against 18.0% in 2014) with diagnosis at stages I-II (72.2% vs. 74.79%), wherein every fifth has stage III-IV. With a tendency to increase in the number of registered patients ≥ 5 years (59.1% vs. 56.5%), the death rate did not change significantly within a year from the time of diagnosis (14.7% vs. 15.6%, respectively). In the structure of specialized care, (65% are patients with the first diagnosis), surgical method accounted for 37-40% by years, the combined was second (up to 20% by years), then radiation and chemotherapy, which together did not exceed 5.0%. Areas with high or low relative rates in relation to the average Ukrainian indicators for all parameters studied were identified. In the presence of regional differences, there is a need for in-depth studies of the state of the issue, including the quality and organization of care.

The work is based on the materials of official statistical reports and covers the dynamics of nephrectomies and, in particular, kidney injury as its cause. Data for ten years (2009-2018) are analyzed, with two five-year periods. This makes it possible to trace not only the nature of changes in absolute indicators over a long period, but also to determine their intensity over the years of study. The situation was assessed in Ukraine as a whole and in the regional aspect. A well-known system of indicators was used: absolute increase (decrease), growth rate (decrease), extensive coefficients, according to which the internal structure was studied. When it was necessary to determine the reliability of the difference between the two parameters, the Student's criterion was calculated. There is a positive trend in the form of a decrease in the total number of nephrectomies in Ukraine as a whole by 5.2% to 2926 operations in 2018. In contrast to the previous five years, when there was an increase (by 5.2%) from 4110 to 4326 in 2013. The percentage of injuries in the structure of nephrectomies did not exceed 2.5% all years of the study. It is characterized by a decrease in each of the periods - its rate was 21.8% and 28.6%, respectively, resulting in an average of 84 ± 6 and 62 ± 5 operations. Regional features on the frequency of injuries are revealed. The difference was an increase of 4 times to 8 areas in 2014-2018, in which there were no kidney injuries that led to organ-bearing operations, while in the previous five years, on the contrary, there was a decrease from 6 to 3. However, the number of areas up to 5 cases per year of kidney injuries, which resulted in nephrectomy, has decreased in the last 5 years (from 76.0% to 56.0%) against their growth over the past five years (from 52.0% to 68.0%). Areas that stand out among others by the number of injuries have been identified. These include mainly those where the mining industry is developed (Dnepropetrovsk, Donetsk, Lugansk, Lviv, Zaporozhye, Rivne).

The paper presents an analysis of official statistics on the incidence and prevalence of kidney cancer (KC) among the adult population of Ukraine and the Western region, as an example to identify certain territorial features and where about 22.4% of patients are concentrated. The main indicators of the results of providing specialized care to such patients were also studied. The main period was 2014–2018, the received data were compared with the previous five years. It was proved that both the incidence and the prevalence of pathology continue to grow in Ukraine and the Western region as a whole, with a similar rate against the background of slightly lower rates in the latter. The incidence rate is generally higher among males and significantly, as well as among females, did not differ in size. The prevalence rate is ahead of the incidence rate, which positively indicates the results of specialized care. Thus, the proportion of patients with newly diagnosed in stages I–II is gradually increasing, but it still remains quite high in stage IV – in every fourth in the country and the third in the region. This is partly due to the low percentage detected during professional examinations (up to 20%), the fluctuations of which have a negative trend. The consequence of the situation is the fact of practical stability of the dead up to a year from the time of diagnosis: in Ukraine in the range of 17–21.7%, in the region 18.3–23.7%. According to the positive trend, there is an increase in patients registered for і5 years; in 2018 to 61.7% and 61.4± 0.9% in Ukraine and the region, respectively. Up to 70% of patients with a first diagnosis receive special treatment. In its structure, the leading one is surgical (63.6±0.9% and 59.7±2.1 in the country and region); the percentage of complex or combined, which ranks second, accounts for 7.9% and 9.7%, respectively, it decreases across the country and increases in the region. Against the background of the general decrease in nephrectomies in Ukraine, their growth was observed in the case of KC everywhere. Every third and fourth operation, respectively, was performed in oblast-oncologic dispensaries. Over the years, postoperative mortality has decreased (by 21% to 1.23 in the whole country), in the region, in the absence of most oblasts, Lviv (by 2.4%) stood out in terms of size. There has been proved the need to focus on the issues of early diagnosis of the disease, which is in the plane of searching new opportunities with the involvement of biomarkers, and organizational measures of various directions., В работе представлен анализ данных официальной статистики о заболеваемости, распространенности рака почки (РП) среди взрослого населения Украины и Западного региона, как примера для выявления особенностей, на который приходится до 23% больных. Изучались также основные показатели результатов оказания специализированной помощи таким больным. Основной период включал 2014–2018 гг., особенность состояла в сопоставлении данных с прошедшим пятилетием. Выявлено, что заболеваемость, распространенность патологии продолжают расти по Украине и, в том числе по Западному региону, с близким между собой темпом прироста на фоне более низких показателей в последнем. Уровень заболеваемости повсеместно выше среди лиц мужского пола и существенно, как и среди женского, не отличался по величине. Темп прироста распространенности опережает заболеваемость, что положительно с точки зрения результатов специализированной помощи. Так, постепенно растет удельный вес больных с впервые выявленным диагнозом в I– II стадиях, однако еще остается достаточно высоким при IV стадии – у каждого четвертого по стране и третьего по региону. Причиной чего частично является низкий процент выявленных при профосмотрах (до 20%), колебания которого имеют отрицательную тенденцию. Следствием ситуации есть факт практической стабильности умерших до года с момента установления диагноза: по Украине в пределах 17–21,7%, по региону 18,3–23,7%. Положительно следует отметить рост больных, состоящих на учете і5 лет, в 2018 году до 61,7% и 61,4±0,9% в Украине и регионе соответственно. До 70% больных с впервые установленным диагнозом получает специальное лечение. В его структуре ведущим является хирургическое (63,6±0,9% и 59,7±2,1% по стране и региону); на процент комплексного или комбинированного, занимающий второе место, приходится 73,9% и 9,7% соответственно, он уменьшается по стране и растет в регионе. На фоне общего снижения в целом по Украине нефрэктомий, их рост отмечен по поводу РП повсеместно. Каждая третья, четвертая операция соответственно выполнялась в облонкодиспансерах. С годами уменьшается послеоперационная летальность (на 21% до 1,23 по стране), в регионе при отсутствии в большинстве областей по величине выделялась Львовская (до 2,4%). Доказана необходимость акцентировать внимание на вопросах ранней диагностики заболевания, которое находится в плоскости поиска новых возможностей с привлечением биомаркеров, так и организационных мероприятий различной направленности., У роботі представлений аналіз офіційних статистичних даних стосовно захворюваності, поширеності раку нирки (РН) серед дорослого населення України та Західного регіону, як прикладу для виявлення окремих територіальних особливостей і де зосереджено близько 22,4% хворих. Вивчались також основні показники результатів надання спеціалізованої допомоги таким хворим. Основним періодом обрано 2014 – 2018 рр., отримані дані співставлялись з минулим п’ятиріччям. Доведено, що як захворюваність, так і поширеність патології продовжує зростати в цілому по Україні та Західному регіону, з близьким між собою темпом на тлі дещо нижчих показників в останньому. Рівень захворюваності повсюдно вищий серед осіб чоловічої статі і суттєво, як і серед жіночої, не різнився за величиною. Темп поширеності випереджає показник при захворюваності, що позитивно свідчить про результати спеціалізованої допомоги. Так, поступово зростає питома вага хворих з вперше виявленим діагнозом в І – ІІ стадіях, проте ще залишається вона достатньо високою при ІV стадії – у кожного четвертого по країні та третього по регіону. Причиною чого частково є низький відсоток, виявлених при профоглядах (до 20%), коливання якого мають негативну тенденцію. Наслідком ситуації є факт практичної стабільності померлих до року з часу встановлення діагнозу: по Україні в межах 17 – 21,7%, по регіону 18,3 – 23,7%. За позитивною тенденцією виділяється зростання хворих, які перебувають на обліку ≥ 5 років; у 2018 р. до 61,7% та 61,4±0,9% в Україні та регіоні відповідно. До 70% хворих з вперше встановленим діагнозом отримує спеціальне лікування. В його структурі провідним є хірургічне (63,6±0,9% та 59,7±2,1 по країні та регіону); на відсоток комплексного або комбінованого, що займає друге місце, приходиться 7,9% та 9,7% відповідно, він зменшується по країні і зростає в регіоні. На тлі загального зменшення по Україні нефректомій, їх зростання відмічено з приводу РН повсюдно. Кожна третя, четверта операція відповідно виконувалась в облонкодиспансерах. З роками зменшується післяопераційна летальність (на 21% до 1,23 по країні), в регіоні при відсутності в більшості областей за величиною виділялася Львівська (до 2,4%). Доведена необхідність акцентувати увагу на питаннях ранньої діагностики захворювання, яке перебуває в площині пошуку нових можливостей із залученням біомаркерів, так і організаційних заходів різної спрямованості.

Aim To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. Materials and methods The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. Results We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. Conclusions A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers.

The dynamics of the primary recognized invalids due to diseases of the genitourinary system in general in Ukraine in two periods: 2008–2012 and 2013–2017 years are presented. The results were analyzed and compared with the indicators in five regions of the country, taking into account the areas of their composition. Official reporting data was used. A decrease in the number of primarily recognized disabled persons, whose structure is prevalent in persons of working age, is set to be 28,9% and 26,4%, respectively, among the total adult and able-bodied population, over the last five years. In 2017, they numbered 1,770 and 1,526 persons, respectively. Positive changes have appeared in a similar tendency among the contingent up to 40 years (by 15,3%). At the same time, the percentage of invalids with the newly established I group (from 14,2±0,9% to 20,7±1,7% in the first and second periods, respectively) is authentically growing. The main tendencies of this process in the regions and oblasts are determined, which will be the basis for the development of regional programs for the prevention of development and complicated course of urological diseases, as well as rehabilitation of the disabled.

The work presents the results of the comparative analysis of findings of the official statistics on morbidity, prevalence of benign hyperplasia of prostatic gland among various aged groups in the Capital and Ukraine as a whole, and the basic indices of medical care to them during 2011 – 2016 with division into two three-year periods. The detected difference confirms the significance of information taking into account the territorial specificities and its actuality to perfect the quality and accessibility of medical aid.

The paper presents the results of statistical analysis of the official reporting forms during a 5 year period (2011–2015 years), concerning the number of nephrectomies, their causes, institutions in which they are performed, as well as the index of postoperative mortality that reflects the quality of medical care. The material is presented in a comparative mannerbetween different Ukrainian regions. In addition, the last two years have been taken into account in connection with the well-known events that have changed the territorial integrity of the country.

The paper presents the results of the study of basic indicators of urological service for the adult population of Ukraine and the results of activities of the service during 2017 compared with the past. It is proved that the developed network, which has a high personnel potential, is stored in the country and works efficiently enough. However, there is a deterioration of health of population due to the accumulation of patients with the most common diseases ("kidney infection" chronic pyelonephritis, cystitis, urolithiasis, benign prostatic hyperplasia), increases cancer incidence (RC, prostate cancer) and prevalence of RC, RSM. Also increases the mortality level at all cancer diseases, and the reduction of indices in urolithiasis and benign prostatic hyperplasia is accompanied by high growth rates among men in the first and among the rural population with urolithiasis, benign prostatic hyperplasia, prostate cancer, malignancies of other organs and systems. Traceability of the regional variability of indicators related to the organization and the quality of provision of specialized assistance is of high socio-economic importance.

The work represents the results of the comparative analysis of criterions on the prevalence, morbidity in chronic pyelonephritis (CPN) among various age groups of adult population in Kyiv and Ukraine as a whole and also the main findings on rendering the specialized service to the patients in the given context. The study period was 6 years and it was divided in two periods (2011–2013 and 2014– 2016) dictated by the well known events in the country which could not but be reflected on the corresponding indicators of the last three years; clearing up of the character of changes in the whole Ukrainian scale and in Kyiv, as the Capital, is of interest from the point of view of state of health in the population and the organization on rendering medical help to the patients in one of the widespread pathologies of the urologic profile. It was found out that practically during all follow-up time the indices of prevalence and morbidity in Kyiv were lower than in the country as a whole. The specificity of changes was displayed in the growth of wide-spreadness during the first three years, which was more intensive in the Capital due to the persons of employable age but throughout the country — above the employable age. Three next years were characterized by its decreased level in Kyiv mainly among the last, preservation of dynamics in Ukraine with decrease of process intensity. As a result, in the Capital during 6 years the increase of patients of the employable age was 5.3%. In 2016 the actual data in Kyiv were the following: among the adult population – 1181,9, employable – 737,5, non-employable – 2269,7, throughout Ukraine – 1567,8; 1186,5; 2398,2 respectively ( 100 tis.). At the same time, in Kyiv morbidity grew, the growth was more intensive during 2014 – 2016, in particular among the persons of retiring age, while through the Ukraine, on the contrary, the general level decrease became slower with years. In 2016 the indicators in Kyiv were as follows: among the adult population – 91,7, employable – 60,7, non-employable – 166,5, throughout Ukraine – 127,6; 118,1; 151,5 respectively (100 tis). There was followed up negative dynamics of rendering the specialized aid to the CPN patients in Kyiv in the form of low indices of regular medical check-up, high lethality which grows with time up to 6.0% in 2016. The above-mentioned needs not only the aiming further monitoring of processes which take place in Kyiv but also performing of studies with the expert assessing of quality of diagnostics and treatment of the indicated category of patients.

The work represents the data of the official statistics (f. N12, 20) for 2011–2016. There has been analyzed the dynamics of the incidence of urolithiasis in the adults population with regard to the age in Kyiv in the comparative aspect with all-Ukrainian one, and also identically those of basic indices of rendering them the specialized service. Two three-year periods (2011–2013 and 2014–2016) were singled out with the aim to follow the specificities of the last years, connected with the known territorial changes in Ukraine. There have been detected the peculiarities of distribution, sickness rate of urolithiasis among the Capital’s population. The tendency in the change of resulted data in the rendered specialized service confirms the actuality of such a work, and motivates the necessity to perform the expert assessment of the quality of diagnostics and treatment, and justifies that the problematic questions must be resolved not only in the medical plane but also in social one as well.