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1. Measurement of the cross-section ratio σψ(2S)/σJ/ψ(1S) in deep inelastic exclusive ep scattering at HERA

Author

H. Abramowicz, I. Abt, L. Adamczyk, M. Adamus, S. Antonelli, V. Aushev, Y. Aushev, O. Behnke, U. Behrens, A. Bertolin, I. Bloch, E.G. Boos, K. Borras, I. Brock, N.H. Brook, R. Brugnera, A. Bruni, P.J. Bussey, A. Caldwell, M. Capua, C.D. Catterall, J. Chwastowski, J. Ciborowski, R. Ciesielski, A.M. Cooper-Sarkar, M. Corradi, F. Corriveau, R.K. Dementiev, R.C.E. Devenish, G. Dolinska, S. Dusini, J. Figiel, B. Foster, G. Gach, E. Gallo, A. Garfagnini, A. Geiser, A. Gizhko, L.K. Gladilin, Yu.A. Golubkov, J. Grebenyuk, I. Gregor, G. Grzelak, O. Gueta, M. Guzik, W. Hain, D. Hochman, R. Hori, Z.A. Ibrahim, Y. Iga, M. Ishitsuka, A. Iudin, F. Januschek, N.Z. Jomhari, I. Kadenko, S. Kananov, U. Karshon, M. Kaur, P. Kaur, D. Kisielewska, R. Klanner, U. Klein, N. Kondrashova, O. Kononenko, Ie. Korol, I.A. Korzhavina, A. Kotański, U. Kötz, N. Kovalchuk, H. Kowalski, B. Krupa, O. Kuprash, M. Kuze, B.B. Levchenko, A. Levy, V. Libov, S. Limentani, M. Lisovyi, E. Lobodzinska, B. Löhr, E. Lohrmann, A. Longhin, D. Lontkovskyi, O.Yu. Lukina, I. Makarenko, J. Malka, S. Mergelmeyer, F. Mohamad Idris, N. Mohammad Nasir, V. Myronenko, K. Nagano, T. Nobe, D. Notz, R.J. Nowak, Yu. Onishchuk, E. Paul, W. Perlański, N.S. Pokrovskiy, M. Przybycień, P. Roloff, I. Rubinsky, M. Ruspa, D.H. Saxon, M. Schioppa, W.B. Schmidke, U. Schneekloth, T. Schörner-Sadenius, L.M. Shcheglova, R. Shevchenko, O. Shkola, Yu. Shyrma, I. Singh, I.O. Skillicorn, W. Słomiński, A. Solano, L. Stanco, N. Stefaniuk, A. Stern, P. Stopa, J. Sztuk-Dambietz, D. Szuba, J. Szuba, E. Tassi, K. Tokushuku, J. Tomaszewska, A. Trofymov, T. Tsurugai, M. Turcato, O. Turkot, T. Tymieniecka, A. Verbytskyi, O. Viazlo, R. Walczak, W.A.T. Wan Abdullah, K. Wichmann, M. Wing, G. Wolf, S. Yamada, Y. Yamazaki, N. Zakharchuk, A.F. Żarnecki, L. Zawiejski, O. Zenaiev, B.O. Zhautykov, N. Zhmak, and D.S. Zotkin

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The exclusive deep inelastic electroproduction of ψ(2S) and J/ψ(1S) at an ep centre-of-mass energy of 317 GeV has been studied with the ZEUS detector at HERA in the kinematic range 2

Published
2016
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2. Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models

Author

Konstantin S. Mineev, Elena V. Kryukova, Igor E. Kasheverov, Natalia S. Egorova, Maxim N. Zhmak, Igor A. Ivanov, Dmitry A. Senko, Alexey V. Feofanov, Anastasia A. Ignatova, Alexander S. Arseniev, Yuri N. Utkin, and Victor I. Tsetlin

Subjects
nicotinic acetylcholine receptors, three-finger proteins, peptide fragments, spatial structure, nuclear magnetic resonance, circular dichroism, Microbiology, QR1-502
Abstract

Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three β-structural loops, similarly to snake venom α-neurotoxin TFPs. Since the central loop II of α-neurotoxins is involved in binding to nAChRs, we have recently synthesized the fragments of Lynx1 central loop, including those with the disulfide between Cys residues introduced at N- and C-termini, some of them inhibiting muscle-type nAChR similarly to the whole-size water-soluble Lynx1 (ws-Lynx1). Literature shows that the main fragment interacting with TFPs is the C-loop of both nAChRs and acetylcholine binding proteins (AChBPs) while some ligand-binding capacity is preserved by analogs of this loop, for example, by high-affinity peptide HAP. Here we analyzed the structural organization of these peptide models of ligands and receptors and its role in binding. Thus, fragments of Lynx1 loop II, loop C from the Lymnaea stagnalis AChBP and HAP were synthesized in linear and Cys-cyclized forms and structurally (CD and NMR) and functionally (radioligand assay on Torpedo nAChR) characterized. Connecting the C- and N-termini by disulfide in the ws-Lynx1 fragment stabilized its conformation which became similar to the loop II within the 1H-NMR structure of ws-Lynx1, the activity being higher than for starting linear fragment but lower than for peptide with free cysteines. Introduced disulfides did not considerably change the structure of HAP and of loop C fragments, the former preserving high affinity for α-bungarotoxin, while, surprisingly, no binding was detected with loop C and its analogs.

Published
2020
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3. Synthesis and Antimicrobial Activity of a New Drug Based on a Retro-Analog of Cathelicidin—Polypeptide SE-33

Author

Ya. V. Makarova, Irina V. Shelukhina, Igor Ivanov, Maxim N. Zhmak, O. P. Bychkova, V. G. Arzumanian, A. S. Budikhina, L. S. Balyasova, A. S. Trenin, and Victor I. Tsetlin

Subjects
0301 basic medicine, Cryptococcus neoformans, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, medicine.medical_treatment, Organic Chemistry, Peptide, biology.organism_classification, Antimicrobial, medicine.disease_cause, 01 natural sciences, Biochemistry, 0104 chemical sciences, Cathelicidin, Microbiology, 03 medical and health sciences, 030104 developmental biology, Staphylococcus aureus, In vivo, medicine, Candida albicans, Peptide sequence
Abstract

Polypeptide SE-33 (SETRPVLNRLFDKIRQVIRKFEKGIKEKSKRFF), which is a retro analog of natural antimicrobial protein cathelicidin LL-37 (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES), was synthesized by the method of solid-phase peptide synthesis. Similar to the natural peptide, polypeptide SE-33 forms an amphipathic alpha helix but has an inverted amino acid sequence compared to cathelicidin. It has been shown the physicochemical properties of polypeptide SE-33 are similar to those of the natural compound. In vitro experiments have shown that polypeptide SE-33 exerts a bactericidal effect on the cells of Staphylococcus aureus Wood 46, which is comparable with the effect of cathelicidin LL-37, as well as pronounced antifungal activity against the clinical isolates of Candida albicans, Cryptococcus neoformans, Rhodotorula mucilaginosa, Trichosporon cutaneum, Geotrichum sp. The MICs of polypeptide SE-33 for different fungal strains were in the range of 31.2 to 1024 μg/mL. Polypeptide SE-33 demonstrated high activity in vivo in the model of vulvovaginal candidiasis (VVC) in mice comparable with that of pimafucin. In the absence of side effects and signs of pathology, polypeptide SE-33 in all doses tested (1, 10 and 50 mg/mL) statistically reduced the vaginal load of the mice compared to the placebo group. The pronounced antibacterial and antifungal activity of polypeptide SE-33, as well as the absence of a toxic effect in the VVC model in mice, suggest polypeptide SE-33 as a promising antimicrobial agent.

Published
2019

4. Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models

Author

Igor E. Kasheverov, Konstantin S. Mineev, Alexey V. Feofanov, Dmitry A. Senko, Maxim N. Zhmak, Victor I. Tsetlin, Alexander S. Arseniev, Natalia S. Egorova, Anastasia A. Ignatova, Yuri N. Utkin, Elena V. Kryukova, and Igor Ivanov

Subjects
0301 basic medicine, Models, Molecular, Circular dichroism, Stereochemistry, Neurotoxins, lcsh:QR1-502, Peptide, Receptors, Nicotinic, Ligands, Biochemistry, lcsh:Microbiology, Article, law.invention, radioligand assay, 03 medical and health sciences, Acetylcholine binding, 0302 clinical medicine, Bacterial Proteins, law, Animals, Humans, Receptor, Molecular Biology, Acetylcholine receptor, Adaptor Proteins, Signal Transducing, Lymnaea, chemistry.chemical_classification, Binding Sites, peptide fragments, spatial structure, Bungarotoxins, Radioligand Assay, circular dichroism, nuclear magnetic resonance, 030104 developmental biology, Nicotinic agonist, chemistry, three-finger proteins, nicotinic acetylcholine receptors, Protein Conformation, beta-Strand, Carrier Proteins, Peptides, 030217 neurology & neurosurgery, Torpedo, Protein Binding
Abstract

Lynx1, membrane-bound protein co-localized with the nicotinic acetylcholine receptors (nAChRs) and regulates their function, is a three-finger protein (TFP) made of three &beta, structural loops, similarly to snake venom &alpha, neurotoxin TFPs. Since the central loop II of &alpha, neurotoxins is involved in binding to nAChRs, we have recently synthesized the fragments of Lynx1 central loop, including those with the disulfide between Cys residues introduced at N- and C-termini, some of them inhibiting muscle-type nAChR similarly to the whole-size water-soluble Lynx1 (ws-Lynx1). Literature shows that the main fragment interacting with TFPs is the C-loop of both nAChRs and acetylcholine binding proteins (AChBPs) while some ligand-binding capacity is preserved by analogs of this loop, for example, by high-affinity peptide HAP. Here we analyzed the structural organization of these peptide models of ligands and receptors and its role in binding. Thus, fragments of Lynx1 loop II, loop C from the Lymnaea stagnalis AChBP and HAP were synthesized in linear and Cys-cyclized forms and structurally (CD and NMR) and functionally (radioligand assay on Torpedo nAChR) characterized. Connecting the C- and N-termini by disulfide in the ws-Lynx1 fragment stabilized its conformation which became similar to the loop II within the 1H-NMR structure of ws-Lynx1, the activity being higher than for starting linear fragment but lower than for peptide with free cysteines. Introduced disulfides did not considerably change the structure of HAP and of loop C fragments, the former preserving high affinity for &alpha, bungarotoxin, while, surprisingly, no binding was detected with loop C and its analogs.

Published
2020

5. α9α10 nicotinic acetylcholine receptors regulate murine bone marrow granulocyte functions

Author

Dmitry A. Senko, Igor E. Kasheverov, Maxim N. Zhmak, Ekaterina V. Pershina, Victor I. Tsetlin, V. G. Safronova, Maxim E. Astashev, Dmitriy A. Serov, Elina A. Jirova, I. V. Tikhonova, and Catherine A. Vulfius

Subjects
0301 basic medicine, Cytotoxicity, Immunologic, Protein subunit, Immunology, Sensation, Pain, Bone Marrow Cells, Granulocyte, Receptors, Nicotinic, Nicotine, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Cell Adhesion, Immunology and Allergy, Animals, Calcium Signaling, RNA, Messenger, Cell adhesion, Neuroinflammation, Cells, Cultured, Acetylcholine receptor, Mice, Inbred BALB C, Chemistry, Hematology, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Nicotinic agonist, Bone marrow, Neurogenic Inflammation, Conotoxins, Reactive Oxygen Species, 030215 immunology, medicine.drug, Granulocytes
Abstract

Polymorphonuclear neutrophilic granulocytes (PMNs) are extremely important in defense of the organism against infections and in inflammatory processes including neuroinflammation and pain sensation. Different subtypes of nicotinic acetylcholine receptors (nAChRs) are involved in modulation of PMN activities. Earlier we determined expression of α2-7, α9, β3, β4 subunits and regulatory role of α7 and α3β2 nAChR subtypes in functions of inflammatory PMNs. Other authors detected mRNA of α9 subunit in bone marrow neutrophils (BM-PMNs). Murine BM-PMNs coming out from the bone marrow, where they develop, to blood were characterized as mature. There was no data for α10 and for the presence of functionally active α9α10 nAChRs in BM-PMNs. Here we detected for the first time mRNA expression of the α10 nAChR subunit in BM-PMNs and confirmed the expression of mRNA for α9 nAChR. With the help of α-conotoxins RgIA and Vc1.1, highly selective antagonists of α9α10 nAChRs, we have revealed participation of α9 and/or α9α10 nAChRs in regulation of cytosolic Ca2+ concentration, cell adhesion, and in generation of reactive oxygen species (ROS). Nicotine, choline, RgIA, and Vc1.1 induced Ca2+ transients in BM-PMNs, enhanced cell adhesiveness and decreased production of ROS indicating involvement of α9, possibly co-assembled with α10, nAChRs in the BM-PMN activity for recruitment and cytotoxicity.

Published
2020

6. Novel Bradykinin-Potentiating Peptides and Three-Finger Toxins from Viper Venom: Combined NGS Venom Gland Transcriptomics and Quantitative Venom Proteomics of the Azemiops feae Viper

Author

Rustam H. Ziganshin, Igor A. Dyachenko, Vladislav V. Babenko, Anh Ngoc Hoang, Yuri N. Utkin, Victor I. Tsetlin, Maxim N. Zhmak, Elvira R. Shaykhutdinova, Vladislav G. Starkov, Arkady N. Murashev, and Christoph Weise

Subjects
0301 basic medicine, VIPeR, Medicine (miscellaneous), venom, Venom, Phospholipase, Proteomics, Viper Venoms, complex mixtures, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, proteomics, Viperidae, bradykinin-potentiating peptides, biology.animal, lcsh:QH301-705.5, venom gland, 030102 biochemistry & molecular biology, biology, 500 Naturwissenschaften und Mathematik::590 Tiere (Zoologie)::590 Tiere (Zoologie), transcriptomic, biology.organism_classification, 030104 developmental biology, Biochemistry, lcsh:Biology (General), Feae’s viper, Proteome, Azemiops feae, Azemiopinae, 500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften, three-finger toxins
Abstract

Feae&rsquo, s viper Azemipos feae belongs to the Azemiopinae subfamily of the Viperidae family. The effects of Viperidae venoms are mostly coagulopathic with limited neurotoxicity manifested by phospholipases A2. From A. feae venom, we have earlier isolated azemiopsin, a novel neurotoxin inhibiting the nicotinic acetylcholine receptor. To characterize other A. feae toxins, we applied label-free quantitative proteomics, which revealed 120 unique proteins, the most abundant being serine proteinases and phospholipases A2. In total, toxins representing 14 families were identified, among which bradykinin-potentiating peptides with unique amino acid sequences possessed biological activity in vivo. The proteomic analysis revealed also basal (commonly known as non-conventional) three-finger toxins belonging to the group of those possessing neurotoxic activity. This is the first indication of the presence of three-finger neurotoxins in viper venom. In parallel, the transcriptomic analysis of venom gland performed by Illumina next-generation sequencing further revealed 206 putative venom transcripts. Together, the study unveiled the venom proteome and venom gland transciptome of A. feae, which in general resemble those of other snakes from the Viperidae family. However, new toxins not found earlier in viper venom and including three-finger toxins and unusual bradykinin-potentiating peptides were discovered.

Published
2020

7. α-Conotoxins Enhance both the In Vivo Suppression of Ehrlich carcinoma Growth and In Vitro Reduction in Cell Viability Elicited by Cyclooxygenase and Lipoxygenase Inhibitors

Author

Victor I. Tsetlin, Tatsiana L. Yanchanka, Yuri N. Utkin, Maxim N. Zhmak, Tatjana Balashevich, T. I. Terpinskaya, and Alexey V. Osipov

Subjects
Cell Survival, Indomethacin, Pharmaceutical Science, Nicotinic Antagonists, Pharmacology, Receptors, Nicotinic, complex mixtures, Article, 03 medical and health sciences, chemistry.chemical_compound, Lipoxygenase, Mice, 0302 clinical medicine, In vivo, Drug Discovery, inhibitors, Animals, Masoprocol, Cyclooxygenase Inhibitors, Conotoxin, Lipoxygenase Inhibitors, Cobra Neurotoxin Proteins, Carcinoma, Ehrlich Tumor, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, 030304 developmental biology, 0303 health sciences, Arachidonic Acid, biology, Carcinoma, Drug Synergism, lipoxygenase, α-conotoxin, Baicalein, Nordihydroguaiaretic acid, cyclooxygenase, Nicotinic agonist, chemistry, nervous system, lcsh:Biology (General), 030220 oncology & carcinogenesis, Ehrlich carcinoma, Flavanones, biology.protein, Arachidonic acid, Cyclooxygenase, Conotoxins
Abstract

Several biochemical mechanisms, including the arachidonic acid cascade and activation of nicotinic acetylcholine receptors (nAChRs), are involved in increased tumor survival. Combined application of inhibitors acting on these two pathways may result in a more pronounced antitumor effect. Here, we show that baicalein (selective 12-lipoxygenase inhibitor), nordihydroguaiaretic acid (non-selective lipoxygenase inhibitor), and indomethacin (non-selective cyclooxygenase inhibitor) are cytotoxic to Ehrlich carcinoma cells in vitro. Marine snail &alpha, conotoxins PnIA, RgIA and ArIB11L16D, blockers of &alpha, 3&beta, 2/&alpha, 6&beta, 2, &alpha, 9&alpha, 10 and &alpha, 7 nAChR subtypes, respectively, as well as &alpha, cobratoxin, a blocker of &alpha, 7 and muscle subtype nAChRs, exhibit low cytotoxicity, but enhance the antitumor effect of baicalein 1.4-fold after 24 h and that of nordihydroguaiaretic acid 1.8&ndash, 3.9-fold after 48 h of cell cultivation. &alpha, Conotoxin MII, a blocker of &alpha, 6-containing and &alpha, 2 nAChR subtypes, increases the cytotoxic effect of indomethacin 1.9-fold after 48 h of cultivation. In vivo, baicalein, &alpha, conotoxins MII and PnIA inhibit Ehrlich carcinoma growth and increase mouse survival, these effects are greatly enhanced by the combined application of &alpha, conotoxin MII with indomethacin or conotoxin PnIA with baicalein. Thus, we show, for the first time, antitumor synergism of &alpha, conotoxins and arachidonic acid cascade inhibitors.

Published
2020

8. Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide

Author

Gleb S. Budylin, Natalia S. Egorova, Elena V. Kryukova, Artjom V. Jegorov, Valentin М. Tabakmakher, Roman G. Efremov, Igor E. Kasheverov, Svetlana Yu. Belukhina, Igor Ivanov, Irina V. Shelukhina, Evgeny A. Shirshin, Maxim N. Zhmak, Denis S. Kudryavtsev, Victor I. Tsetlin, and Nadezhda G. Zhdanova

Subjects
0301 basic medicine, alpha7 Nicotinic Acetylcholine Receptor, Neurotoxins, lcsh:Medicine, Peptide, Plasma protein binding, Molecular Dynamics Simulation, Protein Structure, Secondary, Article, Gel permeation chromatography, 03 medical and health sciences, 0302 clinical medicine, Protein structure, stomatognathic system, Cobra Neurotoxin Proteins, lcsh:Science, chemistry.chemical_classification, Ligand-gated ion channels, Multidisciplinary, lcsh:R, Bungarotoxins, Binding constant, Nicotinic acetylcholine receptor, 030104 developmental biology, chemistry, Snake venom, Biotinylation, Biophysics, lcsh:Q, Molecular modelling, Protein design, Peptides, Biological fluorescence, 030217 neurology & neurosurgery, Protein Binding
Abstract

Snake venom α-neurotoxins, invaluable pharmacological tools, bind with high affinity to distinct subtypes of nicotinic acetylcholine receptor. The combinatorial high-affinity peptide (HAP), homologous to the C-loop of α1 and α7 nAChR subunits, binds biotinylated α-bungarotoxin (αBgt) with nanomolar affinity and might be a protection against snake-bites. Since there are no data on HAP interaction with other toxins, we checked its binding of α-cobratoxin (αCtx), similar to αBgt in action on nAChRs. Using radioiodinated αBgt, we confirmed a high affinity of HAP for αBgt, the complex formation is supported by mass spectrometry and gel chromatography, but only weak binding was registered with αCtx. A combination of protein intrinsic fluorescence measurements with the principal component analysis of the spectra allowed us to measure the HAP-αBgt binding constant directly (29 nM). These methods also confirmed weak HAP interaction with αCtx (>10000 nM). We attempted to enhance it by modification of HAP structure relying on the known structures of α-neurotoxins with various targets and applying molecular dynamics. A series of HAP analogues have been synthesized, HAP[L9E] analogue being considerably more potent than HAP in αCtx binding (7000 nM). The proposed combination of experimental and computational approaches appears promising for analysis of various peptide-protein interactions.

Published
2020

9. Peptides from puff adder Bitis arietans venom, novel inhibitors of nicotinic acetylcholine receptors

Author

T. V. Andreeva, Marina V. Serebryakova, Vladislav G. Starkov, Maxim N. Zhmak, Catherine A. Vulfius, Nina V. Kopylova, Ekaterina N. Spirova, Yuri N. Utkin, Denis S. Kudryavtsev, Ksenia S. Kudryashova, Irina V. Shelukhina, Victor I. Tsetlin, Elena V. Kryukova, and Igor Ivanov

Subjects
0301 basic medicine, Xenopus, Venom, Peptide, Nicotinic Antagonists, Viper Venoms, Receptors, Nicotinic, Toxicology, complex mixtures, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Viperidae, Peptide synthesis, medicine, Animals, Lymnaea, Acetylcholine receptor, chemistry.chemical_classification, Molecular biology, Nicotinic acetylcholine receptor, 030104 developmental biology, Nicotinic agonist, chemistry, Biochemistry, Snake venom, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Peptides, 030217 neurology & neurosurgery, Acetylcholine, medicine.drug
Abstract

Phospholipase A2 (named bitanarin) possessing capability to block nicotinic acetylcholine receptors (nAChRs) was isolated earlier (Vulfius et al., 2011) from puff adder Bitis arietans venom. Further studies indicated that low molecular weight fractions of puff adder venom inhibit nAChRs as well. In this paper, we report on isolation from this venom and characterization of three novel peptides called baptides 1, 2 and 3 that reversibly block nAChRs. To isolate the peptides, the venom of B. arietans was fractionated by gel-filtration and reversed phase chromatography. The amino acid sequences of peptides were established by de novo sequencing using MALDI mass spectrometry. Baptide 1 comprised 7, baptides 2 and 3–10 amino acid residues, the latter being acetylated at the N-terminus. This is the first indication for the presence of such post-translational modification in snake venom proteins. None of the peptides contain cysteine residues. For biological activity studies the peptides were prepared by solid phase peptide synthesis. Baptide 3 and 2 blocked acetylcholine-elicited currents in isolated Lymnaea stagnalis neurons with IC50 of about 50 μM and 250 μM, respectively. In addition baptide 2 blocked acetylcholine-induced currents in muscle nAChR heterologously expressed in Xenopus oocytes with IC50 of about 3 μM. The peptides did not compete with radioactive α-bungarotoxin for binding to Torpedo and α7 nAChRs at concentration up to 200 μM that suggests non-competitive mode of inhibition. Calcium imaging studies on α7 and muscle nAChRs heterologously expressed in mouse neuroblastoma Neuro2a cells showed that on α7 receptor baptide 2 inhibited acetylcholine-induced increasing intracellular calcium concentration with IC50 of 20.6 ± 3.93 μM. On both α7 and muscle nAChRs the suppression of maximal response to acetylcholine by about 50% was observed at baptide 2 concentration of 25 μM, the value being close to IC50 on α7 nAChR. These data are in accord with non-competitive inhibition as follows from α-bungarotoxin binding experiments. The described peptides are the shortest peptides without disulfide bridges isolated from animal venom and capable to inhibit nAChR by non-competitive way.

Published
2016

10. From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

Author

Elena V. Kryukova, Aleksandra I. Garifulina, Yuri N. Utkin, Ekaterina N. Spirova, Denis S. Kudryavtsev, Dmitry S. Lebedev, Maxim N. Zhmak, Victor I. Tsetlin, Igor E. Kasheverov, and Natalia S. Egorova

Subjects
0301 basic medicine, nAChRs, Ly6 family, Xenopus, complex mixtures, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, LYNX1, Neurotoxin, Pharmacology (medical), Acetylcholine receptor, Original Research, Pharmacology, biology, Chemistry, peptide fragments, lcsh:RM1-950, biology.organism_classification, 030104 developmental biology, Nicotinic agonist, lcsh:Therapeutics. Pharmacology, Biochemistry, nervous system, Snake venom, Cell culture, 030220 oncology & carcinogenesis, three-finger proteins, nicotinic acetylcholine receptors, Torpedo
Abstract

The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact with distinct nAChR subtypes. We believed that synthetic fragments of these endogenous proteins might open new ways for drug design because nAChRs are well-known targets for developing analgesics and drugs against neurodegenerative diseases. Since interaction with nAChRs was earlier shown for synthetic fragments of the α-neurotoxin central loop II, we synthesized a 15-membered fragment of human Lynx1, its form with two Cys residues added at the N- and C-termini and forming a disulfide, as well as similar forms of human SLURP1, SLURP2, and of Drosophila sleepless protein (SSS). The IC50 values measured in competition with radioiodinated α-bungarotoxin for binding to the membrane-bound Torpedo californica nAChR were 4.9 and 7.4 µM for Lynx1 and SSS fragments, but over 300 µM for SLURP1 or SLURP2 fragments. The affinity of these compounds for the α7 nAChR in the rat pituitary tumor-derived cell line GH4C1 was different: 13.1 and 147 µM for SSS and Lynx1 fragments, respectively. In competition for the ligand-binding domain of the α9 nAChR subunit, SSS and Lynx1 fragments had IC50 values of about 40 µM, which correlates with the value found for the latter with the rat α9α10 nAChR expressed in the Xenopus oocytes. Thus, the activity of these synthetic peptides against muscle-type and α9α10 nAChRs indicates that they may be useful in design of novel myorelaxants and analgesics.

Published
2019

11. Scorpion toxins interact with nicotinic acetylcholine receptors

Author

Igor E. Kasheverov, Oksana V. Nekrasova, Marina V. Serebryakova, Natalya S. Egorova, Maxim N. Zhmak, Victor I. Tsetlin, Andrei M. Gigolaev, Igor Ivanov, Nikita A. Prokopev, Peter B. Oparin, Anh Ngoc Hoang, Denis S. Kudryavtsev, Yuri N. Utkin, and Alexander A. Vassilevski

Subjects
animal structures, Xenopus, Biophysics, Scorpion Venoms, Nicotinic Antagonists, Receptors, Nicotinic, complex mixtures, Biochemistry, 03 medical and health sciences, Mice, Structural Biology, Genetics, medicine, Neurotoxin, Animals, Molecular Biology, Heterometrus laoticus, Ion channel, 030304 developmental biology, Acetylcholine receptor, 0303 health sciences, biology, Chemistry, 030302 biochemistry & molecular biology, Cell Biology, biology.organism_classification, Nicotinic acetylcholine receptor, Nicotinic agonist, nervous system, Acetylcholine, medicine.drug, Protein Binding
Abstract

Neurotoxins are among the main components of scorpion and snake venoms. Scorpion neurotoxins affect voltage-gated ion channels, while most snake neurotoxins target ligand-gated ion channels, mainly nicotinic acetylcholine receptors (nAChRs). We report that scorpion venoms inhibit α-bungarotoxin binding to both muscle-type nAChR from Torpedo californica and neuronal human α7 nAChR. Toxins inhibiting nAChRs were identified as OSK-1 (α-KTx family) from Orthochirus scrobiculosus and HelaTx1 (κ-KTx family) from Heterometrus laoticus, both being blockers of voltage-gated potassium channels. With an IC50 of 1.6 μm, OSK1 inhibits acetylcholine-induced current through mouse muscle-type nAChR heterologously expressed in Xenopus oocytes. Other well-characterized scorpion toxins from these families also bind to Torpedo nAChR with micromolar affinities. Our results indicate that scorpion neurotoxins present target promiscuity.

Published
2019

12. α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells

Author

Denis S. Kudryavtsev, Elena A. Gondarenko, Maxim N. Zhmak, Nina V. Kopylova, Elena V. Kryukova, Victor I. Tsetlin, Alena F. Palukoshka, Tatsiana L. Yanchanka, Alexey V. Osipov, Yuri N. Utkin, and T. I. Terpinskaya

Subjects
Time Factors, real-time polymerase chain reaction, Pharmaceutical Science, Nicotinic Antagonists, Receptors, Nicotinic, lipoxygenase inhibitor, α-cobratoxin, chemistry.chemical_compound, Lipoxygenase, 0302 clinical medicine, Drug Discovery, Cytotoxic T cell, Lipoxygenase Inhibitors, lcsh:QH301-705.5, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), 0303 health sciences, biology, Brain Neoplasms, Chemistry, Glioma, Nicotinic agonist, 030220 oncology & carcinogenesis, Nicotine, Cell Survival, proliferation, complex mixtures, Article, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, cyclooxygenase inhibitor, Cyclooxygenase Inhibitors, Cobra Neurotoxin Proteins, Cell Proliferation, 030304 developmental biology, viability, medicine.disease, α-conotoxin, Rats, Baicalein, Nordihydroguaiaretic acid, lcsh:Biology (General), nervous system, glioma C6, biology.protein, Cancer research, Cyclooxygenase, Conotoxins, Cobratoxin
Abstract

Among the brain tumors, glioma is the most common. In general, different biochemical mechanisms, involving nicotinic acetylcholine receptors (nAChRs) and the arachidonic acid cascade are involved in oncogenesis. Although the engagement of the latter in survival and proliferation of rat C6 glioma has been shown, there are practically no data about the presence and the role of nAChRs in C6 cells. In this work we studied the effects of nAChR antagonists, marine snail α-conotoxins and snake α-cobratoxin, on the survival and proliferation of C6 glioma cells. The effects of the lipoxygenase and cyclooxygenase inhibitors either alone or together with α-conotoxins and α-cobratoxin were studied in parallel. It was found that α-conotoxins and α-cobratoxin promoted the proliferation of C6 glioma cells, while nicotine had practically no effect at concentrations below 1 µL/mL. Nordihydroguaiaretic acid, a nonspecific lipoxygenase inhibitor, and baicalein, a 12-lipoxygenase inhibitor, exerted antiproliferative and cytotoxic effects on C6 cells. nAChR inhibitors weaken this effect after 24 h cultivation but produced no effects at longer times. Quantitative real-time polymerase chain reaction showed that mRNA for α4, α7, β2 and β4 subunits of nAChR were expressed in C6 glioma cells. This is the first indication for involvement of nAChRs in mechanisms of glioma cell proliferation.

Published
2021

13. Analysis of binding centers in nicotinic receptors with the aid of synthetic peptides

Author

Igor Ivanov, A. V. Odinokov, Igor E. Kasheverov, Ekaterina N. Spirova, Maxim N. Zhmak, M. V. Alfimov, N. V. Egorova, V. I. Tsetlin, Elena V. Kryukova, Irina V. Shelukhina, and Denis S. Kudryavtsev

Subjects
Models, Molecular, 0301 basic medicine, Patch-Clamp Techniques, Neurotoxins, Cholinergic Agents, Biophysics, Peptide, Receptors, Nicotinic, Torpedo, complex mixtures, Biochemistry, Cell Line, Membrane Potentials, Mice, Radioligand Assay, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Calcium imaging, stomatognathic system, Peptide Library, Radioligand, Animals, Humans, Acetylcholine receptor, chemistry.chemical_classification, Binding Sites, Nicotinic Receptors, Chemistry, General Chemistry, General Medicine, Bungarotoxins, Peptide Fragments, Voltage-Sensitive Dye Imaging, Rats, 030104 developmental biology, Nicotinic agonist, nervous system, Oocytes, Calcium, Conotoxins, 030217 neurology & neurosurgery
Abstract

We studies the receptor-binding specificity of the synthetic peptide HAP (High Affinity Peptide) and its analogues, which are regarded as a model of the orthosteric site nicotinic acetylcholine receptors (nAChR). Using radioligand analysis, electrophysiology tests, and calcium imaging, we assessed the ability of HAP to interact with nAChR antagonists: long α-neurotoxins and α-conotoxins. A high affinity of HAP for α-bungarotoxin and the absence of its interaction with α-cobratoxin and α-conotoxins was found. The synthesized analogues of HAP in general retained the properties of the original peptide. Thus, HAP cannot be a model of a ligand-binding site.

Published
2016

14. Measurement of the cross-section ratio σ ψ(2S) / σ J/ψ(1S) in deep inelastic exclusive ep scattering at HERA

Author

Matthew Wing, P. Roloff, N. Kovalchuk, B. B. Levchenko, F. Corriveau, G. Grzelak, E.G. Boos, I.O. Skillicorn, Takuya Nobe, I. Abt, A. Kotański, T. Tsurugai, W. A. T. Wan Abdullah, F. Januschek, I. Kadenko, R. Brugnera, Sebastian Mergelmeyer, Marco Schioppa, Yu.O. Shyrma, Kerstin Borras, Achim Geiser, Ie. Korol, E. Lobodzinska, N. Z. Jomhari, A. Garfagnini, Marcella Capua, L. M. Shcheglova, W. Hain, Leszek Adamczyk, R. Ciesielski, A. M. Cooper-Sarkar, I. A. Korzhavina, Andrii Gizhko, Ada Solano, U. Karshon, S. Antonelli, Yu. Onishchuk, O. Yu. Lukina, Ganna Dolinska, Thomas Schörner-Sadenius, Y. Yamazaki, Yu. A. Golubkov, D. Szuba, N.S. Pokrovskiy, L. Stanco, S. Limentani, R. Shevchenko, A. Longhin, E. Paul, D.H. Saxon, O. Kononenko, Katsuo Tokushuku, A. Bruni, M. Turcato, I. Singh, E. Lohrmann, F. Mohamad Idris, K. Nagano, O. Turkot, P. Stopa, Janusz Chwastowski, R. Klanner, Enrico Tassi, U. Klein, V. Aushev, O. Zenaiev, B. Foster, S. Dusini, K. Wichmann, M. Adamus, W. Słomiński, Ulf Behrens, H. Kowalski, J. Grebenyuk, D. Lontkovskyi, I. Gregor, Mariusz Przybycien, M. Corradi, O. Viazlo, I. Makarenko, Allen Caldwell, L. K. Gladilin, R. K. Dementiev, Y. Iga, N. Kondrashova, Zainol Abidin Ibrahim, A. Bertolin, R.C.E. Devenish, T. Tymieniecka, S. Kananov, U. Kötz, L. Zawiejski, B. Löhr, V. Myronenko, R. J. Nowak, W. Perlanski, P. Kaur, B.O. Zhautykov, Masaki Ishitsuka, J. Tomaszewska, O. Kuprash, Jan Figiel, J. Ciborowski, N. Stefaniuk, A. Iudin, Manjit Kaur, N. Mohammad Nasir, M. Lisovyi, J. Malka, Roman Walczak, Halina Abramowicz, I. Rubinsky, Ingo Bloch, A. Trofymov, D. Notz, D.S. Zotkin, C. D. Catterall, O. Shkola, N. Zhmak, Gy. Wolf, B. Krupa, J. Szuba, S. Yamada, Marcin Pawel Guzik, U. Schneekloth, M. Kuze, Grzegorz Gach, Olaf Behnke, Vladyslav Libov, J. Sztuk-Dambietz, Ian Brock, D. Hochman, R. Hori, Y. Aushev, E. Gallo, Danuta Kisielewska, N. Zakharchuk, Orel Gueta, Andrii Verbytskyi, Marta Ruspa, Aharon Levy, Aleksander Filip Żarnecki, N. H. Brook, Peter Bussey, A. Stern, and W. B. Schmidke

Subjects
exclusive reaction, Nuclear and High Energy Physics, Particle physics, Photon, Proton, HERA, FOS: Physical sciences, HERA, ZEUS, Deep inelastic scattering, Psi meson production, 01 natural sciences, 7. Clean energy, decay modes, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), deep inelastic scattering, quantum chromodynamics, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, Nuclear Experiment, 010306 general physics, Physics, ZEUS (particle detector), Luminosity (scattering theory), production [vector meson], 010308 nuclear & particles physics, Scattering, electroproduction [psi(3685)], photon, ZEUS, scattering [electron p], Deep inelastic scattering, electroproduction [J/psi(3100)], DESY HERA Stor, Psi meson production, kinematics, Vertex (curve), lcsh:QC770-798, High Energy Physics::Experiment, ratio [cross section], experimental results
Abstract

The exclusive deep inelastic electroproduction of $\psi(2S)$ and $J/\psi(1S)$ at an $ep$ centre-of-mass energy of 317 GeV has been studied with the ZEUS detector at HERA in the kinematic range $2 < Q^2 < 80$ GeV$^2$, $30 < W < 210$ GeV and $|t| < 1$ GeV$^2$, where $Q^2$ is the photon virtuality, $W$ is the photon-proton centre-of-mass energy and $t$ is the squared four-momentum transfer at the proton vertex. The data for $2 < Q^2 < 5$ GeV$^2$ were taken in the HERA I running period and correspond to an integrated luminosity of 114 pb$^{-1}$. The data for $5 < Q^2 < 80$ GeV$^2$ are from both HERA I and HERA II periods and correspond to an integrated luminosity of 468 pb$^{-1}$. The decay modes analysed were $\mu^+\mu^-$ and $J/\psi(1S) \,\pi^+\pi^-$ for the $\psi(2S)$ and $\mu^+\mu^-$ for the $J/\psi(1S)$. The cross-section ratio $\sigma_{\psi(2S)}/\sigma_{J/\psi(1S)}$ has been measured as a function of $Q^2, W$ and $t$. The results are compared to predictions of QCD-inspired models of exclusive vector-meson production., Comment: 24 pages, 8 figures

Published
2016

15. Effect of a peptide modeling the nicotinic receptor binding site on the spectral and luminescent properties of dye complexes with cucurbit[8]uril

Author

Maxim N. Zhmak, R. R. Konstantinov, Igor E. Kasheverov, Yu. N. Utkin, G. V. Zakharova, A. V. Odinokov, V. I. Tsetlin, Alexander K. Chibisov, and M. V. Alfimov

Subjects
chemistry.chemical_classification, Aqueous solution, Absorption spectroscopy, Stereochemistry, Peptide, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, complex mixtures, 01 natural sciences, Fluorescence, 0104 chemical sciences, Nicotinic acetylcholine receptor, chemistry.chemical_compound, Nicotinic agonist, nervous system, chemistry, Thioflavin, Physical and Theoretical Chemistry, Absorption (chemistry), 0210 nano-technology
Abstract

The paper presents the results of analysis of the effect of a high-affinity peptide (HAP) homologous to a fragment of the nicotinic acetylcholine receptor (nAChR) on the absorption and fluorescence spectra of thiazole orange and thioflavin T complexes with cucurbit[8]uril in aqueous solution. In the presence of HAP, a change in the absorption spectra of the dye complexes and a drop in the fluorescence intensity occur; for thiazole orange, the fluorescence intensity is restored to the initial level in the presence of α-bungarotoxin capable of high-affinity binding to nAChR. The proposed method make it possible to detect the presence of α-bungarotoxin.

Published
2016

16. Complexes of DNA with the Antimicrobial Peptide LL37 Augment NK Cell Functions by Inducing Type I Interferon Production from Circulating Monocytes and Plasmacytoid Predendritic Cells

Author

Mikhail Pashenkov, Vladimir V. Murugin, Maxim N. Zhmak, Vladimir V Kulakov, and Boris V. Pinegin

Subjects
Adult, Immunology, Enzyme-Linked Immunosorbent Assay, Biology, Lymphocyte Activation, Real-Time Polymerase Chain Reaction, Peripheral blood mononuclear cell, Cell Degranulation, Interferon-gamma, Young Adult, Immune system, Cathelicidins, Interferon, Neoplasms, Virology, medicine, Humans, Cytotoxic T cell, Interferon gamma, Cells, Cultured, Degranulation, DNA, Dendritic Cells, Cell Biology, Middle Aged, Type I interferon production, Molecular biology, Killer Cells, Natural, Interferon Type I, Leukocytes, Mononuclear, Interferon type I, Antimicrobial Cationic Peptides, medicine.drug
Abstract

The cationic antimicrobial peptide, LL37, forms electrostatic complexes with DNA (LL37-DNA), which are potent activators of circulating plasmacytoid predendritic cells (ppDCs) and monocytes. However, the effects of LL37-DNA on other immune cell types, such as NK cells, are poorly characterized. In this study, we show that complexes of human genomic DNA (hgDNA) or synthetic double-stranded oligodeoxynucleotides with LL37 strongly enhance natural cytotoxicity of human peripheral blood mononuclear cells (PBMCs) upon an overnight culture, whereas hgDNA alone has no effect, and LL37 alone is moderately active. LL37-DNA complexes potentiate degranulation of, and interferon (IFN)-γ production by, NK cells upon subsequent encounter of K562 target cells. The complexes do not influence percentages of NK cells among PBMCs or the expression of cytotoxic proteins by NK cells. Using neutralizing anticytokine antibodies and immunomagnetic depletion of different subpopulations of PBMCs, we found that the effect of LL37-DNA on NK cells is indirect and mediated by type I IFNs produced by monocytes and, to a lesser extent, by ppDCs. We discuss possible roles of LL37-DNA complexes in the regulation of NK cell functions and in the treatment of cancer.

Published
2015

17. Improving therapeutic potential of antibacterial spider venom peptides: coarse-grain molecular dynamics guided approach

Author

Peter V. Dubovskii, Igor Ivanov, Anastasia A. Ignatova, Pavel E. Volynsky, Alexey V. Feofanov, Maxim N. Zhmak, and Roman G. Efremov

Subjects
0301 basic medicine, Staphylococcus aureus, Erythrocytes, Lipid Bilayers, Spider Venoms, Venom, Molecular Dynamics Simulation, Hemolysis, 03 medical and health sciences, Molecular dynamics, Drug Discovery, Escherichia coli, Animals, Humans, Amino Acid Sequence, Pharmacology, Lachesana tarabaevi, Spider, Microscopy, Confocal, 030102 biochemistry & molecular biology, Chemistry, Circular Dichroism, Spiders, Antibacterial peptide, Anti-Bacterial Agents, 030104 developmental biology, Biochemistry, Molecular Medicine, Antibacterial activity, Peptides, Hydrophobic and Hydrophilic Interactions
Abstract

Aim: Spider venom is a rich source of antibacterial peptides, whose hemolytic activity is often excessive. Methodology: How to get rid of it? Using latarcins from Lachesana tarabaevi and oxyopinin Oxt 4a from Oxyopes takobius spider venoms we performed coarse-grained molecular dynamics simulations of these peptides in the presence of lipid bilayers, mimicking erythrocyte membranes. This identified hemolytically active fragments within Oxt 4a and latarcins. Then, we synthesized five 20-residue peptides, containing different parts of the Oxt 4a and latarcin-1 sequence, carrying mutations within the identified regions. Conclusion: The antibacterial and hemolytic tests suggested that the three of the synthesized peptides demonstrated substantial decrease in hemolytic activity, retaining, or even exceeding antibacterial potential of the parent peptides.

Published
2018

18. Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant

Author

Margarita A Salmova, A. V. Lobanov, Natalya S. Egorova, G. A. Slashcheva, Victor I. Tsetlin, Maxim N. Zhmak, Elena A Tukhovskaya, Inessa S. Muzyka, Igor Ivanov, I. N. Kravchenko, Irina V. Shelukhina, Alexandra I. Garifulina, Ekaterina A Rasskazova, Yuri N. Utkin, and V. A. Rykov

Subjects
0301 basic medicine, Male, medicine.drug_class, Health, Toxicology and Mutagenesis, Xenopus, lcsh:Medicine, Investigation of the preclinical profile of azemiopsin demonstrated its high affinity and specificity for muscle type nicotinic acetylcholine receptor as well as good muscle relaxant capacity. Toxicology studies in mice indicated that azemiopsin was well tolerated during chronic dosing and showed no immunotoxicity, allergenic or mutagenic activity, which made it a good candidate for application as a local muscle relaxant, CHO Cells, Nicotinic Antagonists, Viper Venoms, Pharmacology, Receptors, Nicotinic, Toxicology, Article, nicotinic acetylcholine receptor, azemiopsin, preclinical studies, toxicity, pharmacokinetics, myorelaxant, Key Contribution, Rats, Sprague-Dawley, 03 medical and health sciences, Cricetulus, Cell Line, Tumor, Toxicity Tests, medicine, Animals, Humans, Receptor, Mice, Inbred ICR, GABAA receptor, Chemistry, lcsh:R, Antagonist, Muscle relaxant, Effective dose (pharmacology), Nicotinic acetylcholine receptor, 030104 developmental biology, Neuromuscular Agents, Toxicity, Oocytes, Female, Peptides, Acetylcholine, medicine.drug
Abstract

Azemiopsin (Az), a linear peptide from the Azemiops feae viper venom, contains no disulfide bonds, is a high-affinity and selective inhibitor of nicotinic acetylcholine receptor (nAChR) of muscle type and may be considered as potentially applicable nondepolarizing muscle relaxant. In this study, we investigated its preclinical profile in regard to in vitro and in vivo efficacy, acute and chronic toxicity, pharmacokinetics, allergenic capacity, immunotoxicity and mutagenic potency. The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 μM (EC100) acetylcholine but was less potent (IC50 ~ 3 μM) at α7 nAChR activated by 10 μM (EC50) acetylcholine and had a low affinity to α4β2 and α3-containing nAChR, as well as to GABAA or 5HT3 receptors. Its muscle relaxant effect was demonstrated at intramuscular injection to mice at doses of 30–300 µg/kg, 30 µg/kg being the initial effective dose and 90 µg/kg—the average effective dose. The maximal muscle relaxant effect of Az was achieved in 10 min after the administration and elimination half-life of Az in mice was calculated as 20–40 min. The longest period of Az action observed at a dose of 300 µg/kg was 55 min. The highest acute toxicity (LD50 510 μg/kg) was observed at intravenous injection of Az, at intramuscular or intraperitoneal administration it was less toxic. The peptide showed practically no immunotoxic, allergenic or mutagenic capacity. Overall, the results demonstrate that Az has good drug-like properties for the application as local muscle relaxant and in its parameters, is not inferior to the relaxants currently used. However, some Az modification might be effective to extend its narrow therapeutic window, a typical characteristic and a weak point of all nondepolarizing myorelaxants.

Published
2017

19. Neurotoxins from Snake Venoms and α-Conotoxin ImI Inhibit Functionally Active Ionotropic γ-Aminobutyric Acid (GABA) Receptors

Author

Maxim N. Zhmak, Vladislav G. Starkov, Werner Sieghart, Irina V. Shelukhina, Yuri N. Utkin, Joachim Ramerstorfer, Dmitry A. Dolgikh, Ekaterina N. Lyukmanova, Elena V. Kryukova, Victor I. Tsetlin, Lina V. Son, Denis S. Kudryavtsev, Igor Ivanov, Lucy O. Ojomoko, and Igor E. Kasheverov

Subjects
Molecular Dynamics Simulation, Biology, Inhibitory postsynaptic potential, complex mixtures, Biochemistry, Aminobutyric acid, Protein Structure, Secondary, Mice, chemistry.chemical_compound, Cell Line, Tumor, Animals, Neurotoxin, Elapidae, Cobra Neurotoxin Proteins, Receptor, Molecular Biology, Binding Sites, GABAA receptor, Cell Biology, Receptors, GABA-A, Muscimol, chemistry, Snake venom, Biophysics, Conotoxins, Signal Transduction, Ionotropic effect
Abstract

Ionotropic receptors of γ-aminobutyric acid (GABAAR) regulate neuronal inhibition and are targeted by benzodiazepines and general anesthetics. We show that a fluorescent derivative of α-cobratoxin (α-Ctx), belonging to the family of three-finger toxins from snake venoms, specifically stained the α1β3γ2 receptor; and at 10 μm α-Ctx completely blocked GABA-induced currents in this receptor expressed in Xenopus oocytes (IC50 = 236 nm) and less potently inhibited α1β2γ2 ≈ α2β2γ2 > α5β2γ2 > α2β3γ2 and α1β3δ GABAARs. The α1β3γ2 receptor was also inhibited by some other three-finger toxins, long α-neurotoxin Ls III and nonconventional toxin WTX. α-Conotoxin ImI displayed inhibitory activity as well. Electrophysiology experiments showed mixed competitive and noncompetitive α-Ctx action. Fluorescent α-Ctx, however, could be displaced by muscimol indicating that most of the α-Ctx-binding sites overlap with the orthosteric sites at the β/α subunit interface. Modeling and molecular dynamic studies indicated that α-Ctx or α-bungarotoxin seem to interact with GABAAR in a way similar to their interaction with the acetylcholine-binding protein or the ligand-binding domain of nicotinic receptors. This was supported by mutagenesis studies and experiments with α-conotoxin ImI and a chimeric Naja oxiana α-neurotoxin indicating that the major role in α-Ctx binding to GABAAR is played by the tip of its central loop II accommodating under loop C of the receptors.

Published
2015

20. Natural Compounds Interacting with Nicotinic Acetylcholine Receptors: From Low-Molecular Weight Ones to Peptides and Proteins

Author

Catherine A. Vulfius, Irina V. Shelukhina, Igor Ivanov, Valentin A. Stonik, Denis S. Kudryavtsev, Yuri N. Utkin, Maxim N. Zhmak, Victor I. Tsetlin, Tatyana N. Makarieva, and Igor E. Kasheverov

Subjects
Health, Toxicology and Mutagenesis, lcsh:Medicine, three-finger Ly6 proteins, Venom, Review, Nicotinic Antagonists, Receptors, Nicotinic, Toxicology, snake venom phospholipases A2, complex mixtures, law.invention, α-neurotoxins, law, Conus, mental disorders, Animals, Humans, Nicotinic Agonists, Receptor, Acetylcholine receptor, biology, musculoskeletal, neural, and ocular physiology, lcsh:R, Proteins, low-molecular weight agonists and antagonists, biology.organism_classification, Molecular Weight, Nicotinic agonist, Biochemistry, nervous system, Snake venom, α-conotoxins, Hermissenda crassicornis, nicotinic acetylcholine receptors, sense organs, Conotoxins, Peptides, Torpedo
Abstract

Nicotinic acetylcholine receptors (nAChRs) fulfill a variety of functions making identification and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR research are d-tubocurarine, snake venom protein α-bungarotoxin (α-Bgt), and α-conotoxins, neurotoxic peptides from Conus snails. Various new compounds of different structural classes also interacting with nAChRs have been recently identified. Among the low-molecular weight compounds are alkaloids pibocin, varacin and makaluvamines C and G. 6-Bromohypaphorine from the mollusk Hermissenda crassicornis does not bind to Torpedo nAChR but behaves as an agonist on human α7 nAChR. To get more selective α-conotoxins, computer modeling of their complexes with acetylcholine-binding proteins and distinct nAChRs was used. Several novel three-finger neurotoxins targeting nAChRs were described and α-Bgt inhibition of GABA-A receptors was discovered. Information on the mechanisms of nAChR interactions with the three-finger proteins of the Ly6 family was found. Snake venom phospholipases A2 were recently found to inhibit different nAChR subtypes. Blocking of nAChRs in Lymnaea stagnalis neurons was shown for venom C-type lectin-like proteins, appearing to be the largest molecules capable to interact with the receptor. A huge nAChR molecule sensible to conformational rearrangements accommodates diverse binding sites recognizable by structurally very different compounds.

Published
2015

21. Measurement of high-Q (2) charged current deep inelastic scattering cross sections with a longitudinally polarised positron beam at HERA

Author

H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWAL, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A. N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, D. BARTSCH, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, T. BOLD, E. G. BOOS, M. BORODIN, K. BORRAS, D. BOSCHERINI, D. BOT, S. K. BOUTLE, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P. J. BUSSEY, J. M. BUTTERWORTH, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C. D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, F. CINDOLO, A. M. COOPER SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DE FAVEREAU, J. DEL PESO, R. K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R. C. E. DEVENISH, D. DOBUR, B. A. DOLGOSHEIN, A. T. DOYLE, V. DRUGAKOV, L. S. DURKIN, S. DUSINI, Y. EISENBERG, P. F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M. I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L. K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, Y.U. A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J. C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, U. HOLM, R. HORI, K. HORTON, A. HÜTTMANN, G. IACOBUCCI, Z. A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H. P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T. W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I. I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L. A. KHEIN, J. Y. KIM, D. KISIELEWSKA, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, D. KOLLAR, P. KOOIJMAN, I.E. KOROL, I. A. KORZHAVINA, A. KOTA´NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, V. A. KUZMIN, A. LEE, B. B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T. Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, J. H. LOIZIDES, K. R. LONG, A. LONGHIN, D. LONTKOVSKYI, O. Y.U. LUKINA, P. LUZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J. F. MARTIN, A. MASTROBERARDINO, T. MATSUMOTO, M. C. K. MATTINGLY, I. A. MELZER PELLMANN, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J. D. MORRIS, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, U. NOOR, D. NOTZ, R. J. NOWAK, A. E. NUNCIO QUIROZ, B. Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, Y.U. ONISHCHUK, O. OTA, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J. M. PAWLAK, B. PAWLIK, P. G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N. S. POKROVSKIY, A. POLINI, A. S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D. D. REEDER, B. REISERT, Z. REN, J. REPOND, Y. D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, A. A. SAVIN, D. H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W. B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER SADENIUS, J. SCHWARTZ, F. SCIULLI, L. M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I. O. SKILLICORN, W. SLOMI´NSKI, W. H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T. P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK, D. SZUBA, J. SZUBA, A. D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, V. VIAZLO, N. N. VLASOV, O. VOLYNETS, R. WALCZAK, W. A. T. WAN ABDULLAH, J. J. WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K. WRONA, A. G. YAGÜES MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A. F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B. O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, M. ZOLKO, D. S. ZOTKIN, Z. ZULKAPLI, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, SARTORELLI, GABRIELLA, H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWAL, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A.N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, D. BARTSCH, M. BASILE, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, T. BOLD, E.G. BOOS, M. BORODIN, K. BORRAS, D. BOSCHERINI, D. BOT, S.K. BOUTLE, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P.J. BUSSEY, J.M. BUTTERWORTH, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C.D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, L. CIFARELLI, F. CINDOLO, A. CONTIN, A.M. COOPER-SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DE FAVEREAU, J. DEL PESO, R.K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R.C.E. DEVENISH, D. DOBUR, B.A. DOLGOSHEIN, A.T. DOYLE, V. DRUGAKOV, L.S. DURKIN, S. DUSINI, Y. EISENBERG, P.F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M.I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L.K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, YU.A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA-BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J.C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, U. HOLM, R. HORI, K. HORTON, A. HÜTTMANN, G. IACOBUCCI, Z.A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H.-P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T.W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I.I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L.A. KHEIN, J.Y. KIM, D. KISIELEWSKA, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, D. KOLLAR, P. KOOIJMAN, IE.KOROL, I.A. KORZHAVINA, A. KOTA´NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, V.A. KUZMIN, A. LEE, B.B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T.Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, J.H. LOIZIDES, K.R. LONG, A. LONGHIN, D. LONTKOVSKYI, O.YU. LUKINA, P. LUZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J.F. MARTIN, A. MASTROBERARDINO, T. MATSUMOTO, M.C.K. MATTINGLY, I.-A. MELZER-PELLMANN, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J.D. MORRIS, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, U. NOOR, D. NOTZ, R.J. NOWAK, A.E. NUNCIO-QUIROZ, B.Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, YU. ONISHCHUK, O. OTA, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J.M. PAWLAK, B. PAWLIK, P.G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N.S. POKROVSKIY, A. POLINI, A.S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D.D. REEDER, B. REISERT, Z. REN, J. REPOND, Y.D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, G. SARTORELLI, A.A. SAVIN, D.H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W.B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER-SADENIUS, J. SCHWARTZ, F. SCIULLI, L.M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I.O. SKILLICORN, W. SLOMI´NSKI, W.H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T.P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK, D. SZUBA, J. SZUBA, A.D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE-ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, V. VIAZLO, N.N. VLASOV, O. VOLYNETS, R.WALCZAK, W.A.T. WAN ABDULLAH, J.J. WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H.WOLFE, K.WRONA, A.G. YAGÜES-MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A.F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B.O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, M. ZOLKO, D.S. ZOTKIN, Z. ZULKAPLI, Zeus (IHEF, IoP, FNWI), Precision Frontier, and UCL - SST/IRMP - Institut de recherche en mathématique et physique

Subjects
Physics and Astronomy (miscellaneous), LUND MONTE-CARLO, HERA, FOS: Physical sciences, 01 natural sciences, JET FRAGMENTATION, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Cross section (physics), Positron, High Energy Physics, ZEUS Collaboration, 0103 physical sciences, EVENT GENERATOR, ddc:530, QCD ANALYSIS, 010306 general physics, PROTON COLLISIONS, EP INTERACTIONS, Engineering (miscellaneous), Charged current, Event generator, Physics, LEFT-RIGHT SYMMETRY, Luminosity (scattering theory), ZEUS (particle detector), 010308 nuclear & particles physics, ZEUS BARREL CALORIMETER, Deep inelastic scattering, CENTRAL TRACKING DETECTOR, PARTON DISTRIBUTIONS, High Energy Physics::Experiment, Atomic physics
Abstract

Measurements of the cross sections for charged current deep inelastic scattering in e+p collisions with a longitudinally polarised positron beam are presented. The measurements are based on a data sample with an integrated luminosity of 132 pb^-1 collected with the ZEUS detector at HERA at a centre-of-mass energy of 318 GeV. The total cross section is presented at positive and negative values of the longitudinal polarisation of the positron beams. The single-differential cross-sections ds/dQ^2, ds/dx and ds/dy are presented for Q^2 > 200 GeV^2. The reduced cross-section is presented in the kinematic range 200 < Q^2 < 60,000 GeV^2 and 0.006 < x < 0.562. The measurements agree well with the predictions of the Standard Model. The results are used to determine a lower limit on the mass of a hypothetical right-handed W boson., 33 pages, 11 figures, 7 tables

Published
2016

22. Inclusive dijet cross sections in neutral current deep inelastic scattering at HERA

Author

H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWAL, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A. N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, D. BARTSCH, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, T. BOLD, E. G. BOOS, M. BORODIN, K. BORRAS, D. BOSCHERINI, D. BOT, S. K. BOUTLE, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P. J. BUSSEY, J. M. BUTTERWORTH, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C. D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, F. CINDOLO, A. M. COOPER SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DE FAVEREAU, J. DEL PESO, R. K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R. C. E. DEVENISH, D. DOBUR, B. A. DOLGOSHEIN, A. T. DOYLE, V. DRUGAKOV, L. S. DURKIN, S. DUSINI, Y. EISENBERG, P. F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M. I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L. K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, Y.U. A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J. C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, U. HOLM, R. HORI, K. HORTON, A. HÜTTMANN, G. IACOBUCCI, Z. A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H. P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T. W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I. I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L. A. KHEIN, J. Y. KIM, D. KISIELEWSKA, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, D. KOLLAR, P. KOOIJMAN, I.E. KOROL, I. A. KORZHAVINA, A. KOTA´NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, V. A. KUZMIN, A. LEE, B. B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T. Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, J. H. LOIZIDES, K. R. LONG, A. LONGHIN, D. LONTKOVSKYI, O. Y.U. LUKINA, P. LUZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J. F. MARTIN, A. MASTROBERARDINO, T. MATSUMOTO, M. C. K. MATTINGLY, I. A. MELZER PELLMANN, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J. D. MORRIS, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, U. NOOR, D. NOTZ, R. J. NOWAK, A. E. NUNCIO QUIROZ, B. Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, Y.U. ONISHCHUK, O. OTA, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J. M. PAWLAK, B. PAWLIK, P. G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N. S. POKROVSKIY, A. POLINI, A. S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D. D. REEDER, B. REISERT, Z. REN, J. REPOND, Y. D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, A. A. SAVIN, D. H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W. B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER SADENIUS, J. SCHWARTZ, F. SCIULLI, L. M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I. O. SKILLICORN, W. SLOMI´NSKI, W. H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T. P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK, D. SZUBA, J. SZUBA, A. D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, V. VIAZLO, N. N. VLASOV, O. VOLYNETS, R. WALCZAK, W. A. T. WAN ABDULLAH, J. J. WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K. WRONA, A. G. YAGÜES MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A. F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B. O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, M. ZOLKO, D. S. ZOTKIN, Z. ZULKAPLI, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, SARTORELLI, GABRIELLA, Precision Frontier, H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWAL, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A.N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, D. BARTSCH, M. BASILE, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, T. BOLD, E.G. BOOS, M. BORODIN, K. BORRAS, D. BOSCHERINI, D. BOT, S.K. BOUTLE, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P.J. BUSSEY, J.M. BUTTERWORTH, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C.D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, L. CIFARELLI, F. CINDOLO, A. CONTIN, A.M. COOPER-SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DE FAVEREAU, J. DEL PESO, R.K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R.C.E. DEVENISH, D. DOBUR, B.A. DOLGOSHEIN, A.T. DOYLE, V. DRUGAKOV, L.S. DURKIN, S. DUSINI, Y. EISENBERG, P.F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M.I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L.K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, YU.A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA-BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J.C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, U. HOLM, R. HORI, K. HORTON, A. HÜTTMANN, G. IACOBUCCI, Z.A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H.-P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T.W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I.I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L.A. KHEIN, J.Y. KIM, D. KISIELEWSKA, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, D. KOLLAR, P. KOOIJMAN, IE.KOROL, I.A. KORZHAVINA, A. KOTA´NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, V.A. KUZMIN, A. LEE, B.B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T.Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, J.H. LOIZIDES, K.R. LONG, A. LONGHIN, D. LONTKOVSKYI, O.YU. LUKINA, P. LUZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J.F. MARTIN, A. MASTROBERARDINO, T. MATSUMOTO, M.C.K. MATTINGLY, I.-A. MELZER-PELLMANN, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J.D. MORRIS, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, U. NOOR, D. NOTZ, R.J. NOWAK, A.E. NUNCIO-QUIROZ, B.Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, YU. ONISHCHUK, O. OTA, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J.M. PAWLAK, B. PAWLIK, P.G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N.S. POKROVSKIY, A. POLINI, A.S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D.D. REEDER, B. REISERT, Z. REN, J. REPOND, Y.D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, G. SARTORELLI, A.A. SAVIN, D.H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W.B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER-SADENIUS, J. SCHWARTZ, F. SCIULLI, L.M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I.O. SKILLICORN, W. SLOMI´NSKI, W.H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T.P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK, D. SZUBA, J. SZUBA, A.D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE-ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, V. VIAZLO, N.N. VLASOV, O. VOLYNETS, R.WALCZAK, W.A.T. WAN ABDULLAH, J.J. WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H.WOLFE, K.WRONA, A.G. YAGÜES-MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A.F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B.O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, M. ZOLKO, D.S. ZOTKIN, Z. ZULKAPLI, and Zeus (IHEF, IoP, FNWI)

Subjects
Particle physics, Photon, MONTE-CARLO GENERATOR, Physics and Astronomy (miscellaneous), HERA, FOS: Physical sciences, COLOR DIPOLE MODEL, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, LEPTON-NUCLEON SCATTERING, 0103 physical sciences, ddc:530, Invariant mass, QCD ANALYSIS, 010306 general physics, Nuclear Experiment, Engineering (miscellaneous), Quantum chromodynamics, Physics, Neutral current, 010308 nuclear & particles physics, Scattering, ZEUS BARREL CALORIMETER, Deep inelastic scattering, PHYSICS EVENT GENERATION, CENTRAL TRACKING DETECTOR, JET-PRODUCTION, PARTON DISTRIBUTIONS, High Energy Physics::Experiment, HADRON-COLLISIONS, Reference frame
Abstract

Single- and double-differential inclusive dijet cross sections in neutral current deep inelastic ep scattering have been measured with the ZEUS detector using an integrated luminosity of 374 pb^-1. The measurement was performed at large values of the photon virtuality, Q^2, between 125 and 20000 GeV^2. The jets were reconstructed with the k_T cluster algorithm in the Breit reference frame and selected by requiring their transverse energies in the Breit frame, E_T,B^jet, to be larger than 8 GeV. In addition, the invariant mass of the dijet system, M_jj, was required to be greater than 20 GeV. The cross sections are described by the predictions of next-to-leading-order QCD., 33 pages, 14 figures, 8 tables

Published
2010

23. Mitochondria express several nicotinic acetylcholine receptor subtypes to control various pathways of apoptosis induction

Author

Lyudmyla Koval, Olena Lykhmus, Maxim N. Zhmak, Serhiy Komisarenko, Maryna Skok, and Galyna Gergalova

Subjects
Apoptosis, Receptors, Nicotinic, Biology, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Ganglion type nicotinic receptor, medicine, Animals, Receptor, Acetylcholine receptor, Brain, Cytochromes c, Cell Biology, Acetylcholine, Mitochondria, Cell biology, Protein Subunits, Nicotinic acetylcholine receptor, Nicotinic agonist, Liver, Organ Specificity, Signal transduction, Alpha-4 beta-2 nicotinic receptor, Signal Transduction, medicine.drug
Abstract

Nicotinic acetylcholine receptors control survival, proliferation and cytokine release in non-excitable cells. Previously we reported that α7 nicotinic receptors were present in the outer membranes of mouse liver mitochondria to regulate mitochondrial pore formation and cytochrome c release. Here we used a wide spectrum of nicotinic receptor subunit-specific antibodies to show that mitochondria express several nicotinic receptor subtypes in a tissue-specific manner: brain and liver mitochondria contain α7β2, α4β2 and less α3β2 nicotinic receptors, while mitochondria from the lung express preferentially α3β4 receptor subtype; all of them are non-covalently connected to voltage-dependent anion channels and control cytochrome c release. By using selective ligands of different nicotinic receptor subtypes (acetylcholine (1 μM) or dihydro-β-erythroidine (1 μM) for α4β2), conotoxin MII (1 nM) for α3β2, MLA (50 nM) for α7β2 and acetylcholine (10 μM) for all subtypes) and apoptogenic agents triggering different mitochondrial signaling pathways (1 μM wortmannin, 90 μM Ca(2+) or 0.5 mM H₂O₂) it was found that α7β2 receptors affect mainly PI₃K/Akt pathway, while α3β2 and α4β2 nAChRs also significantly influence CaKMII- and Src-dependent pathways. It is concluded that cholinergic regulation in mitochondria is realized through multiple nicotinic receptor subtypes, which control various pathways inducing mitochondrial type of apoptosis.

Published
2014

24. High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method

Author

Ekaterina N. Spirova, Igor Ivanov, Denis S. Kudryavtsev, Igor E. Kasheverov, Elena Zelepuga, Valentin M. Tabakmakher, Anton O. Chugunov, Victor I. Tsetlin, Irina V. Shelukhina, Roman G. Efremov, and Maxim N. Zhmak

Subjects
0301 basic medicine, Circular dichroism, alpha7 Nicotinic Acetylcholine Receptor, Allosteric regulation, Molecular Dynamics Simulation, Article, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, Structure–activity relationship, Computer Simulation, Acetylcholine receptor, chemistry.chemical_classification, Multidisciplinary, Chemistry, Circular Dichroism, Biomolecule, food and beverages, Biological activity, Small molecule, 030104 developmental biology, Nicotinic agonist, Drug Design, Mutation, Biophysics, Conotoxins, Allosteric Site, 030217 neurology & neurosurgery
Abstract

Despite some success for small molecules, elucidating structure–function relationships for biologically active peptides — the ligands for various targets in the organism — remains a great challenge and calls for the development of novel approaches. Some of us recently proposed the Protein Surface Topography (PST) approach, which benefits from a simplified representation of biomolecules’ surface as projection maps, which enables the exposure of the structure–function dependencies. Here, we use PST to uncover the “activity pattern” in α-conotoxins — neuroactive peptides that effectively target nicotinic acetylcholine receptors (nAChRs). PST was applied in order to design several variants of the α-conotoxin PnIA, which were synthesized and thoroughly studied. Among the best was PnIA[R9, L10], which exhibits nanomolar affinity for the α7 nAChR, selectivity and a slow wash-out from this target. Importantly, these mutations could hardly be delineated by “standard” structure-based drug design. The proposed combination of PST with a set of experiments proved very efficient for the rational construction of new bioactive molecules.

Published
2016

25. Production of Z0 bosons in elastic and quasi-elastic ep collisions at HERA

Author

P. Schleper, E. Lobodzinska, S. Fang, Sebastian Mergelmeyer, L. M. Shcheglova, R. Yoshida, W. H. Smith, Thomas Schörner-Sadenius, Y. Yamazaki, Mário Costa, A. Galas, Aleksander Filip Żarnecki, Katsuo Tokushuku, V.V. Sosnovtsev, I. I. Katkov, D. Gladkov, Yu. A. Golubkov, E. Paul, Nazar Bartosik, L. Stanco, R. Ingbir, Enrico Tassi, J. J. Whitmore, G. DʼAgostini, Alexander Spiridonov, I. A. Melzer-Pellmann, Janusz Chwastowski, J. M. Pawlak, D.D. Reeder, L. Suszycki, Allen Caldwell, B. Löhr, A. Garfagnini, Ramoona Shehzadi, Antonino Zichichi, Wojciech Slominski, A. Verbytskyi, T. Theedt, R. Hori, A. Eskreys, Marco Schioppa, S. Magill, P. G. Pelfer, F. Corriveau, G. Grzelak, Claire Gwenlan, S. Kitamura, Zainol Abidin Ibrahim, F. Januschek, U. Samson, Andrea Contin, O. Yu. Lukina, B. Reisert, F. Mohamad Idris, M. Derrick, T. Tymieniecka, Danuta Kisielewska, K. Nagano, Nazar Stefaniuk, S. De Pasquale, B. B. Levchenko, T. P. Stewart, Janna Katharina Behr, A. Longhin, P.M. Kooijman, A. Keramidas, Rosario Nania, U. Kötz, H. Stadie, A. Kotański, Iwona Grabowska-Bold, M. Jüngst, Ben Bylsma, M. Vázquez, G. Hartner, H. Hartmann, Claudia Glasman, V. Drugakov, Krzysztof Piotrzkowski, Marcella Capua, Kenneth Long, Ulf Behrens, Federico Cindolo, H. Kowalski, Achim Geiser, B.O. Zhautykov, Alexander Tapper, Rainer Mankel, N.N. Vlasov, A. Nigro, A. Antonov, J. Repond, W. B. Schmidke, J. Maeda, D. Szuba, R. J. Nowak, T. Namsoo, Leszek Adamczyk, N. Kondrashova, Lev Khein, Takuya Nobe, Alessia Bruni, M.I. Ferrero, D. Lontkovskyi, C. Youngman, Halina Abramowicz, V. Trusov, H.-P. Jakob, J. F. Martin, H.G.J.M. Tiecke, A. Parenti, I. Kadenko, M. Basile, T. Haas, John Hart, P. Stopa, G. Dolinska, J. D. Morris, A. Pellegrino, F. Karstens, Ozan Arslan, S. Kananov, I. Makarenko, M.C.K. Mattingly, L. S. Durkin, R. Brugnera, Juan Terron, Ada Solano, K. Papageorgiu, Y. Iga, P.F. Ermolov, O. Zabiegalov, Kerstin Borras, V. Bokhonov, O. Zenaiev, R. Hamatsu, O. Bachynska, Z. Ren, S. Limentani, Dong-Chul Son, A. E. Nuncio-Quiroz, W. A. T. Wan Abdullah, I. O. Skillicorn, Els Koffeman, Matthew Wing, Masaki Ishitsuka, I. Rubinsky, M. Turcato, Alessandro Bertolin, James Ferrando, O. Kononenko, B. Brzozowska, B. Musgrave, V. Aushev, I. Gregor, I. Abt, E. Brownson, A. T. Doyle, A. Montanari, Anselmo Margotti, J. Grebenyuk, I. Singh, L.W. Wiggers, U. Klein, O. Turkot, P. Roloff, V. Sola, V. Libov, S. Miglioranzi, C. Blohm, N. Zhmak, Gy. Wolf, V. Monaco, D. Bot, K. Wichmann, M. Adamus, T. Kanno, G. Marini, B. A. Dolgoshein, W. Hain, Orel Gueta, S. Antonelli, Alexander Savin, Wolfram Dietrich Zeuner, A. Bamberger, Marta Ruspa, A.G. Robertson, Mariusz Przybycien, Ie. Korol, D. Notz, M. Corradi, O. Viazlo, D.S. Zotkin, Marcello Bindi, B. Pawlik, C. D. Catterall, T. W. Jones, N. Brümmer, T. Tsurugai, J. Szuba, A. N. Barakbaev, Ian Brock, Y. Ning, Sergei Chekanov, S. Yamada, A. Stern, K. Wrona, Dirk-Uwe Bartsch, J. Sztuk-Dambietz, B. Foster, K. Olkiewicz, Wolfgang Lohmann, S. Dusini, J. Schwartz, A. Lee, E. Hilger, H. Wolfe, G. Bari, Shima Shimizu, E.G. Boos, Graziano Bruni, I. A. Korzhavina, F. Sciulli, S. Bhadra, J. Y. Kim, U. Karshon, Pietro Antonioli, Luisa Cifarelli, L. K. Gladilin, Tomasz Bold, A. Hüttmann, D. H. Saxon, R. K. Dementiev, B.Y. Oh, D. Hochman, S. Schlenstedt, P. J. Bussey, M. Arneodo, P. Göttlicher, O. Kuprash, Jan Figiel, O. Behnke, S. Fazio, G. Grigorescu, M. Lisovyi, Roberto Sacchi, A.S. Proskuryakov, N.S. Pokrovskiy, Aharon Levy, Zukhaimira Zolkapli, F. Dal Corso, M. Wlasenko, R.C.E. Devenish, A. Gizhko, K. Mujkic, Hanno Perrey, R. Ciesielski, Elisabetta Gallo, Yu. Onishchuk, A.G. Yagües-Molina, J. Tomaszewska, J. Del Peso, W. Perlanski, G. F. Susinno, A. Raval, Fernando Barreiro, S.I. Suchkov, Didar Dobur, Y. Aushev, Lorenzo Bellagamba, N. Coppola, N. Okazaki, M. Kuze, Pawel Plucinski, E. Lohrmann, R. Klanner, Anna Mastroberardino, Amanda Cooper-Sarkar, Y.D. Ri, Grzegorz Gach, Kyrylo Bondarenko, T. Y. Ling, O. Gogota, Y. Eisenberg, R. Walczak, Giuseppe Barbagli, G. Sartorelli, Marcin Pawel Guzik, U. Schneekloth, R. Aggarwal, V. Schönberg, L. Zawiejski, P. Kaur, A. Stifutkin, B. Kahle, Roberto Carlin, J. Ciborowski, Manjit Kaur, J. Malka, Davide Boscherini, A. Polini, and I. Gialas

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, ZEUS (particle detector), Proton, 010308 nuclear & particles physics, Hadron, Elementary particle, HERA, 01 natural sciences, Standard Model, Nuclear physics, Pseudorapidity, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, Nucleon
Abstract

The production of Z 0 bosons in the reaction ep→eZ 0 p (*) , where p (*) stands for a proton or a low-mass nucleon resonance, has been studied in ep collisions at HERA using the ZEUS detector. The analysis is based on a data sample collected between 1996 and 2007, amounting to 496pb -1 of integrated luminosity. The Z 0 was measured in the hadronic decay mode. The elasticity of the events was ensured by a cut on η max max is the maximum pseudorapidity of energy deposits in the calorimeter defined with respect to the proton beam direction. A signal was observed at the Z 0 mass. The cross section of the reaction ep→eZ 0 p (*) was measured to be σ(ep→eZ 0 p (*) )=0.13±0.06(stat.)±0.01(syst.) pb, in agreement with the Standard Model prediction of 0.16 pb. This is the first measurement of Z 0 production in ep collisions. © 2012 Elsevier B.V.

Published
2013

26. Production of the excited charm mesons and at HERA

Author

M. Jüngst, Ben Bylsma, D. Szuba, Marco Schioppa, P. G. Pelfer, G. Hartner, Francois Corriveau, H. Hartmann, Claudia Glasman, Katsuo Tokushuku, V.V. Sosnovtsev, D. Gladkov, A. Kotański, B. B. Levchenko, V. Drugakov, Janusz Chwastowski, Takuya Nobe, J. Behr, Anna Mastroberardino, U. Klein, O. Turkot, S. Schlenstedt, J. F. Martin, A. Verbytskyi, Lev Khein, A. Bruni, Alexander Tapper, Antonino Zichichi, R. Hori, B. Brzozowska, Halina Abramowicz, S. Kananov, F. J. Sciulli, F. Dal Corso, A. Keramidas, Pawel Plucinski, Yuji Yamazaki, B.O. Zhautykov, Nazar Bartosik, Enrico Tassi, J. J. Whitmore, I. Kadenko, M. Wlasenko, J. Schwartz, G. Grzelak, Hartmut Stadie, Kenneth Long, A. Bertolin, A. Eskreys, Ie. Korol, L. M. Shcheglova, Claire Gwenlan, Y.D. Ri, S. Yamada, T. Namsoo, I. Gialas, A. Gizhko, G. Bari, F. Januschek, S. De Pasquale, S. Fang, J. Maeda, Giovanna Bruni, John Hart, D.D. Reeder, P.F. Ermolov, O. Yu. Lukina, B. Reisert, A. Longhin, Y. Eisenberg, Ramoona Shehzadi, R. Walczak, Alexander Spiridonov, I. A. Melzer-Pellmann, Michele Arneodo, Sebastian Mergelmeyer, R.C.E. Devenish, Ozan Arslan, A. Nigro, A.G. Yagües-Molina, L. Zawiejski, M. Turcato, Kunihiro Nagano, A. Pellegrino, M. Vázquez, W. Perlanski, G. F. Susinno, Andrea Contin, James Ferrando, J. Tomaszewska, I. Rubinsky, I. Gregor, O. Zabiegalov, Jose Repond, I. A. Korzhavina, O. Kuprash, M.C.K. Mattingly, Jan Figiel, G. Sartorelli, L. S. Durkin, B. Löhr, N. Okazaki, L. Stanco, R. Ingbir, J. Del Peso, Valentina Sola, A. Raval, John Morris, I. Abt, R. Hamatsu, O. Bachynska, B. Musgrave, E. Lobodzinska, Leszek Adamczyk, G. Grigorescu, L. Suszycki, P. Kaur, S. Magill, T. Theedt, Marcella Capua, Fernando Barreiro, Els Koffeman, S. Kitamura, M.I. Ferrero, A.G. Robertson, P. Stopa, A. E. Nuncio-Quiroz, V. Monaco, Mariusz Przybycien, F. Karstens, M. Corradi, O. Viazlo, S.I. Suchkov, Peter Schleper, Didar Dobur, W. A. T. Wan Abdullah, A. Montanari, K. Mujkic, J. Szuba, W. H. Smith, W. Hain, D. Bot, Rainer Mankel, N.N. Vlasov, A. Stifutkin, Y. Aushev, J. Sztuk-Dambietz, A. M. Cooper-Sarkar, O. Zenaiev, Thomas Schörner-Sadenius, D. Notz, D.S. Zotkin, C. D. Catterall, T. W. Jones, K. Olkiewicz, I. I. Katkov, K. Wichmann, M. Adamus, G. Marini, Mário Costa, Wolfram Dietrich Zeuner, Anselmo Margotti, Ada Solano, J. Grebenyuk, Y. Ning, Olaf Behnke, L.W. Wiggers, Yu. A. Golubkov, E. Paul, H. Wolfe, Kyrylo Bondarenko, T. Y. Ling, O. Gogota, A. Bamberger, V. Bokhonov, E. Hilger, F. Mohamad Idris, Marcello Bindi, B. Pawlik, H.G.J.M. Tiecke, A. Parenti, Robert Klanner, K. Wrona, N. Coppola, E.G. Boos, Hanno Perrey, U. Karshon, S. Bhadra, R. Ciesielski, Elisabetta Gallo, B. Foster, Nazar Stefaniuk, D. Boscherini, S. Limentani, Rosario Nania, S. Dusini, Yu. Onishchuk, V. Libov, Krzysztof Piotrzkowski, B.Y. Oh, N. Zhmak, Gy. Wolf, T. Kanno, J. Y. Kim, Pietro Antonioli, Luisa Cifarelli, Alexander Savin, I. Singh, L. K. Gladilin, R. K. Dementiev, N. Kondrashova, B. Kahle, N.S. Pokrovskiy, Zukhaimira Zolkapli, A. N. Barakbaev, Allen Caldwell, Giuseppe Barbagli, N. Brümmer, Roberto Carlin, T. Tsurugai, S. Miglioranzi, I. Makarenko, Y. Iga, Zainol Abidin Ibrahim, M. Derrick, T. Tymieniecka, U. Kötz, J. Ciborowski, Wolfgang Lohmann, R. J. Nowak, I. O. Skillicorn, Manjit Kaur, J. Malka, A. Polini, W. Słomiński, Ulf Behrens, Federico Cindolo, H. Kowalski, R. Yoshida, A. Stern, Matthew Wing, Zhongliang Ren, D. Lontkovskyi, V. Trusov, P. Roloff, J. M. Pawlak, V. Aushev, A. Garfagnini, W. B. Schmidke, U. Samson, Danuta Kisielewska, T. P. Stewart, G. Dolinska, K. Papageorgiu, D. Hochman, M. Basile, T. Haas, P. J. Bussey, S. Fazio, Roberto Sacchi, Aharon Levy, Sergei Chekanov, Dirk-Uwe Bartsch, Marcin Pawel Guzik, A. Lee, L. Bellagamba, A. Galas, Aleksander Filip Żarnecki, Ian Brock, U. Schneekloth, R. Aggarwal, A. Hüttmann, D. H. Saxon, P. Göttlicher, M. Kuze, E. Brownson, A. T. Doyle, E. Lohrmann, M. Ishitsuka, B. A. Dolgoshein, Orel Gueta, Marta Ruspa, Grzegorz Gach, V. Schönberg, Iwona Grabowska-Bold, A. Antonov, C. Youngman, H.-P. Jakob, R. Brugnera, Kerstin Borras, Dong-Chul Son, P.M. Kooijman, Achim Geiser, O. Kononenko, Juan Terron, C. Blohm, S. Antonelli, A.S. Proskuryakov, Shima Shimizu, Tomasz Bold, and G. DʼAgostini

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Meson, 010308 nuclear & particles physics, HERA, 01 natural sciences, 7. Clean energy, Helicity, D-1, Charm quark, Nuclear physics, Excited state, 0103 physical sciences, Heavy quark effective theory, High Energy Physics::Experiment, 010306 general physics
Abstract

The production of the excited charm mesons D 1 (2420) and D2*(2460) in ep collisions has been measured with the ZEUS detector at HERA using an integrated luminosity of 373pb -1 . The masses of the neutral and charged states, the widths of the neutral states, and the helicity parameter of D 1 (2420) 0 were determined and compared with other measurements and with theoretical expectations. The measured helicity parameter of the D10 allows for some mixing of S- and D-waves in its decay to D *± π Π . The result is also consistent with a pure D-wave decay. Ratios of branching fractions of the two decay modes of the D2*(2460)0 and D2*(2460)± states were measured and compared with previous measurements. The fractions of charm quarks hadronising into D 1 and D2* were measured and are consistent with those obtained in e + e - annihilations. © 2012 Elsevier B.V.

Published
2013

27. Production of exclusive dijets in diffractive deep inelastic scattering at HERA

Author

N. Zhmak, Gy. Wolf, B. B. Levchenko, Allen Caldwell, J. Szuba, Francois Corriveau, Zainol Abidin Ibrahim, T. Tymieniecka, Vladyslav Libov, R. Brugnera, Yuji Yamazaki, Sebastian Mergelmeyer, Ian Brock, A. Kotański, N. Kondrashova, U. Kötz, Yu.O. Shyrma, A. Trofymov, E. Lobodzinska, Ganna Dolinska, R. J. Nowak, D. H. Saxon, Kerstin Borras, Aleksander Filip Żarnecki, Katsuo Tokushuku, W. Słomiński, Ada Solano, Ulf Behrens, H. Kowalski, Masaki Ishitsuka, O. Kononenko, Thomas Schörner-Sadenius, S. Limentani, Janusz Chwastowski, D. Lontkovskyi, J. Ciborowski, Amanda Cooper-Sarkar, P. Stopa, Robert Klanner, V. Aushev, N. H. Brook, I. Singh, F. Mohamad Idris, Danuta Kisielewska, Marcin Pawel Guzik, J. Tomaszewska, K. Wichmann, M. Adamus, U. Schneekloth, R. Hori, I. Makarenko, O. Yu. Lukina, R. Shevchenko, Y. Iga, Manjit Kaur, I. Abt, Takuya Nobe, D. Notz, N. Zakharchuk, Marcella Capua, A. Longhin, E.G. Boos, O. Zenaiev, R. Ciesielski, Elisabetta Gallo, J. Malka, Roman Walczak, Aharon Levy, Mariusz Przybycien, N. Z. Jomhari, J. Grebenyuk, M. Corradi, O. Viazlo, M. Kuze, Yu. Onishchuk, D.S. Zotkin, C. D. Catterall, E. Lohrmann, B. Foster, I. O. Skillicorn, S. Dusini, D. Hochman, A. Stern, N.S. Pokrovskiy, Grzegorz Gach, Andrii Gizhko, Y. Aushev, L. K. Gladilin, Marco Schioppa, Nataliia Kovalchuk, Yu. A. Golubkov, E. Paul, R. K. Dementiev, J. Sztuk-Dambietz, W. Hain, O. Shkola, S. Kananov, U. Karshon, B. Löhr, Olaf Behnke, O. Kuprash, B.O. Zhautykov, O. Turkot, Jan Figiel, S. Yamada, A. Iudin, U. Klein, M. Lisovyi, Orel Gueta, B. Krupa, Matthew Wing, N. Mohammad Nasir, Andrii Verbytskyi, Marta Ruspa, A. Garfagnini, V. Myronenko, W. A. T. Wan Abdullah, I. Rubinsky, P. Roloff, Ingo Bloch, Achim Geiser, R.C.E. Devenish, N. Stefaniuk, W. Perlanski, I. Kadenko, T. Tsurugai, Ie. Korol, A. Bertolin, S. Antonelli, Peter Bussey, I. Gregor, L. Zawiejski, M. Turcato, W. B. Schmidke, I. A. Korzhavina, Kunihiro Nagano, L. M. Shcheglova, P. Kaur, D. Szuba, L. Stanco, Halina Abramowicz, A. Bruni, Enrico Tassi, G. Grzelak, F. Januschek, and Leszek Adamczyk

Subjects
Physics, Antiparticle, Particle physics, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Hadron, Elementary particle, HERA, Inelastic scattering, Deep inelastic scattering, 01 natural sciences, Nuclear physics, Pair production, 0103 physical sciences, High Energy Physics::Experiment, Production (computer science), 010306 general physics, Engineering (miscellaneous)
Abstract

Production of exclusive dijets in diffractive deep inelastic $$e^\pm p$$ scattering has been measured with the ZEUS detector at HERA using an integrated luminosity of 372 pb $$^{-1}$$ . The measurement was performed for $$\gamma ^{*}$$ –p centre-of-mass energies in the range $$90< W < {250}\,{\mathrm{GeV}}$$ and for photon virtualities $$Q^2 > {25}\,{\mathrm{GeV}^{2}}$$ . Energy flows around the jet axis are presented. The cross section is presented as a function of $$\beta $$ and $$\phi $$ , where $$\beta =x/x_\mathrm{I\!P}$$ , x is the Bjorken variable and $$x_\mathrm{I\!P}$$ is the proton fractional longitudinal momentum loss. The angle $$\phi $$ is defined by the $$\gamma ^{*}$$ –dijet plane and the $$\gamma ^{*}$$ – $$e^\pm $$ plane in the rest frame of the diffractive final state. The $$\phi $$ cross section is measured in bins of $$\beta $$ . The results are compared to predictions from models based on different assumptions about the nature of the diffractive exchange.

Published
2016

28. Azemiopsin from Azemiops feae Viper Venom, a Novel Polypeptide Ligand of Nicotinic Acetylcholine Receptor

Author

Vladislav G. Starkov, Sarah C. R. Lummis, Ngoc Anh Hoang, Daniel Bertrand, Andrew J. Thompson, Werner Sieghart, Igor E. Kasheverov, T. V. Andreeva, Maxim N. Zhmak, Joachim Ramerstorfer, Yuri N. Utkin, Elena V. Kryukova, Victor I. Tsetlin, and Christoph Weise

Subjects
Neurotransmitter Transport, Male, Nicotinic Acetylcholine Receptors, Molecular Sequence Data, Radioreceptor Assays, Venom, Peptide, Viper Venoms, Receptors, Nicotinic, Ligands, complex mixtures, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Peptide synthesis, Toxins, Animals, Amino Acid Sequence, Molecular Biology, Peptide sequence, Chromatography, High Pressure Liquid, 030304 developmental biology, Cys-loop Receptors, chemistry.chemical_classification, Mice, Inbred BALB C, 0303 health sciences, Sequence Homology, Amino Acid, Edman degradation, Circular Dichroism, Snake Venom, 030302 biochemistry & molecular biology, Cell Biology, 3. Good health, Nicotinic acetylcholine receptor, chemistry, Snake venom, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Structure and Folding, Azemiops feae, Neurotoxin, Peptides, Cys-loop receptors
Abstract

Background: Venoms from rare snake species may contain toxins of new structural or/and pharmacological types. Results: Amino acid sequence of the new polypeptide azemiopsin isolated from Azemiops feae viper venom was established, and its biological activity was determined. Conclusion: Azemiopsin is the first natural toxin that blocks nicotinic acetylcholine receptors and does not contain disulfide bridges. Significance: Azemiopsin is the first member of a new toxin group., Azemiopsin, a novel polypeptide, was isolated from the Azemiops feae viper venom by combination of gel filtration and reverse-phase HPLC. Its amino acid sequence (DNWWPKPPHQGPRPPRPRPKP) was determined by means of Edman degradation and mass spectrometry. It consists of 21 residues and, unlike similar venom isolates, does not contain cysteine residues. According to circular dichroism measurements, this peptide adopts a β-structure. Peptide synthesis was used to verify the determined sequence and to prepare peptide in sufficient amounts to study its biological activity. Azemiopsin efficiently competed with α-bungarotoxin for binding to Torpedo nicotinic acetylcholine receptor (nAChR) (IC50 0.18 ± 0.03 μm) and with lower efficiency to human α7 nAChR (IC50 22 ± 2 μm). It dose-dependently blocked acetylcholine-induced currents in Xenopus oocytes heterologously expressing human muscle-type nAChR and was more potent against the adult form (α1β1ϵδ) than the fetal form (α1β1γδ), EC50 being 0.44 ± 0.1 μm and 1.56 ± 0.37 μm, respectively. The peptide had no effect on GABAA (α1β3γ2 or α2β3γ2) receptors at a concentration up to 100 μm or on 5-HT3 receptors at a concentration up to 10 μm. Ala scanning showed that amino acid residues at positions 3–6, 8–11, and 13–14 are essential for binding to Torpedo nAChR. In biological activity azemiopsin resembles waglerin, a disulfide-containing peptide from the Tropidechis wagleri venom, shares with it a homologous C-terminal hexapeptide, but is the first natural toxin that blocks nAChRs and does not possess disulfide bridges.

Published
2012

29. The effect of MII α-conotoxin and its N-terminal derivatives on Ca2+- and Na+-signals induced by nicotine in SH-SY5Y neuroblastoma cells

Author

Reeta Talka, Raimo K. Tuominen, Leonard Khiroug, V. I. Tsetlin, Outi Salminen, A. M. Surin, Elena V. Kryukova, Maxim N. Zhmak, A. S. Strukov, and Igor E. Kasheverov

Subjects
urogenital system, Stereochemistry, Organic Chemistry, Biochemistry, chemistry.chemical_compound, Nicotinic agonist, chemistry, embryonic structures, Glycine, Conotoxin, Tyrosine, Fluorescein isothiocyanate, reproductive and urinary physiology, Homeostasis, Intracellular, Acetylcholine receptor
Abstract

Nicotinic acetylcholine receptors (nAChRs) are involved in the regulation of intracellular Ca2+-dependent processes both in normal and pathological states. α-Conotoxins from the venom of Conus marine mollusks are a valuable tool for the investigation of the pharmacological action and functional role of nAChRs. Analogues of α-conotoxin MII labeled by Bolton-Hunter reagent (BH-MII) or fluorescein isothiocyanate (FITC-MII) on the N-terminal glycine residue have been synthesized in the present work. Fluorescence microscopy studies of SH-SY5Y neuroblastoma cells loaded with Ca2+ indicator Fura-2, or by both Ca2+ indicator Fluo-4 and Na+ indicator SBFI, were used to test the effect of MII modification on its ability to block Ca2+ and Na+ signals induced by nicotine. Measurements in SH-SY5Y cells showed that kinetics of the increase and recovery of the concentration of free Ca2+ ([Ca2+]i) upon nicotine application and washout was different from that for free Na+ ([Na+]i), this being evidence of differences in the mechanism of Ca2+ and Na+ homeostasis regulation. MII suppressed the nicotine-induced increase of [Ca2+]i and [Na+]i in a concentration-dependent manner. An additional tyrosine residue added to the N-terminus of one of the MII derivatives caused a significant decrease in the inhibitory action of MII; this decrease was even more pronounced when a large FITC label was introduced into MII. The BH-MII derivative had an inhibitory effect similar to that of unmodified α-conotoxin. MII and its iodinated derivatives are promising tools for radioligand assays.

Published
2012

30. Measurement of the t dependence in exclusive photoproduction of ϒ(1S) mesons at HERA

Author

R. Yoshida, G. DʼAgostini, Claudia Glasman, V. Drugakov, Takuya Nobe, C. Zhou, Yuji Yamazaki, Lev Khein, J. M. Pawlak, Marco Schioppa, P. G. Pelfer, S. Kananov, A. Garfagnini, J. Behr, A. Bruni, U. Samson, B.O. Zhautykov, Kenneth Long, G. Bari, J. Maeda, Giovanna Bruni, Enrico Tassi, J. J. Whitmore, N. Brümmer, Hanno Perrey, F. Mohamad Idris, Katsuo Tokushuku, V.V. Sosnovtsev, D. Gladkov, Janusz Chwastowski, T. Tsurugai, A. Verbytskyi, O. Gogota, R. Ciesielski, Elisabetta Gallo, U. Klein, Yu. Onishchuk, A. M. Cooper-Sarkar, A. Pellegrino, Rosario Nania, Wolfgang Lohmann, U. Noor, I. I. Katkov, W. B. Schmidke, V. Aushev, M. Basile, Pawel Plucinski, O. Tomalak, T. Haas, S. Fang, Sebastian Mergelmeyer, Yu. A. Golubkov, F. J. Sciulli, John Hart, M.C.K. Mattingly, L. S. Durkin, E. Paul, Ie. Korol, P.M. Kooijman, R. Hamatsu, O. Bachynska, Achim Geiser, L. M. Shcheglova, K. Papageorgiu, Els Koffeman, Krzysztof Piotrzkowski, I. Abt, Peter Schleper, O. Kuprash, Jan Figiel, T. Theedt, K. Oliver, Marcello Bindi, B. Pawlik, D. Hochman, Ada Solano, M. Adamus, I. A. Korzhavina, Juan Terron, I. Rubinsky, Giuseppe Barbagli, Y.D. Ri, V. Bokhonov, S. Schlenstedt, P. J. Bussey, G. Marini, A. N. Barakbaev, Alexander Spiridonov, I. A. Melzer-Pellmann, Wolfram Dietrich Zeuner, A. Bamberger, N. Bartosik, L. Stanco, R. Ingbir, E. Hilger, O. Yu. Lukina, B. Reisert, S. Fazio, Leszek Adamczyk, R.C.E. Devenish, Roberto Sacchi, Hartmut Stadie, Danuta Kisielewska, U. Karshon, V. Monaco, T. P. Stewart, I. Makarenko, D.D. Reeder, W. Hain, M.I. Ferrero, A. Stern, G. Grigorescu, M. Lisovyi, S. Limentani, D. Boscherini, P.F. Ermolov, A. Eskreys, S. Antonelli, Anna Mastroberardino, I. O. Skillicorn, Y. Eisenberg, I. Gialas, Aharon Levy, M. Zolko, S. Bhadra, Ramoona Shehzadi, B.Y. Oh, Sergei Chekanov, Matthew Forrest, A.G. Robertson, A. Longhin, F. Karstens, Dirk-Uwe Bartsch, Mariusz Przybycien, M. Corradi, R. Walczak, Antonino Zichichi, Jose Repond, A. Nigro, A. Lee, L. Bellagamba, N.S. Pokrovskiy, W. Słomiński, J. Schwartz, Ulf Behrens, Federico Cindolo, H. Kowalski, Zukhaimira Zolkapli, G. Grzelak, E. Lobodzinska, Valentina Sola, K. Mujkic, P. Stopa, I. Singh, M. Vázquez, D. Lontkovskyi, L. Suszycki, R. Hori, G. Dolinska, Claire Gwenlan, Ian Brock, F. Januschek, Allen Caldwell, O. Zenaiev, A. Galas, A. Salii, Aleksander Filip Żarnecki, James Ferrando, K. Horton, S. De Pasquale, Andrea Contin, W. H. Smith, Zainol Abidin Ibrahim, Anselmo Margotti, M. Derrick, J. Grebenyuk, L.W. Wiggers, H.G.J.M. Tiecke, A. Parenti, I. Gregor, T. Tymieniecka, A.S. Proskuryakov, Thomas Schörner-Sadenius, U. Kötz, Mário Costa, A. Hüttmann, D. H. Saxon, I. Kadenko, Edouard Boos, Y. Ning, Matthew Wing, P. Göttlicher, F. Dal Corso, G. Sartorelli, R. J. Nowak, P. Roloff, Francois Corriveau, S. Magill, A. Kotański, O. Volynets, T. Namsoo, Shima Shimizu, V. Libov, E. Brownson, Tomasz Bold, N. Zhmak, A. T. Doyle, Alexander Tapper, Gy. Wolf, T. Kanno, B. A. Dolgoshein, Orel Gueta, Alexander Savin, Marta Ruspa, J. Szuba, M. Wlasenko, A. E. Nuncio-Quiroz, B. Löhr, D. Notz, S. Kitamura, D.S. Zotkin, C. D. Catterall, T. W. Jones, S. Yamada, W. A. T. Wan Abdullah, A. Montanari, D. Bot, M. Jüngst, Ben Bylsma, D. Szuba, G. Hartner, H. Hartmann, Halina Abramowicz, Michele Arneodo, Kyrylo Bondarenko, T. Y. Ling, W. Perlanski, G. F. Susinno, Robert Klanner, K. Olkiewicz, N. Okazaki, Marcella Capua, H. Wolfe, John Morris, Rainer Mankel, N.N. Vlasov, K. Wrona, B. Foster, S. Dusini, J. Y. Kim, Pietro Antonioli, Luisa Cifarelli, L. K. Gladilin, R. K. Dementiev, H.-P. Jakob, R. Brugnera, Kerstin Borras, Dong-Chul Son, Y. Aushev, Masaki Ishitsuka, C. Blohm, Fernando Barreiro, S.I. Suchkov, Didar Dobur, S. Miglioranzi, Iwona Grabowska-Bold, A. Antonov, Olaf Behnke, C. Youngman, N. Coppola, A.G. Yagües-Molina, J. Tomaszewska, J. Del Peso, A. Raval, B. B. Levchenko, J. F. Martin, B. Brzozowska, O. Viazlo, J. Sztuk-Dambietz, M. Kuze, E. Lohrmann, Grzegorz Gach, B. Kahle, Roberto Carlin, A. Keramidas, A. Bertolin, L. Zawiejski, M. Turcato, Kunihiro Nagano, V. Schönberg, B. Musgrave, P. Kaur, A. Stifutkin, J. Ciborowski, Manjit Kaur, Marcin Pawel Guzik, U. Schneekloth, R. Aggarwal, Y. Iga, J. Malka, A. Polini, and Zhongliang Ren

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Proton, Meson, 010308 nuclear & particles physics, Hadron, Elementary particle, HERA, 01 natural sciences, 7. Clean energy, Particle identification, Baryon, Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics, Nucleon
Abstract

The exclusive photoproduction reaction γ p → ϒ ( 1 S ) p has been studied with the ZEUS detector in ep collisions at HERA using an integrated luminosity of 468 pb − 1 . The measurement covers the kinematic range 60 W 220 GeV and Q 2 1 GeV 2 , where W is the photon–proton centre-of-mass energy and Q 2 is the photon virtuality. The exponential slope, b, of the t dependence of the cross section, where t is the squared four-momentum transfer at the proton vertex, has been measured, yielding b = 4.3 − 1.3 + 2.0 ( stat . ) − 0.6 + 0.5 ( syst . ) GeV − 2 . This constitutes the first measurement of the t dependence of the γ p → ϒ ( 1 S ) p cross section.

Published
2012

31. Combination of measurements of inclusive deep inelastic e±p scattering cross sections and QCD analysis of HERA data: H1 and ZEUS Collaborations

Author

R.C.E. Devenish, G. Grzelak, Jenny List, D. Ozerov, Claire Gwenlan, Marina Rotaru, F. Januschek, Richard Polifka, Fabian Zomer, J. Szuba, N. Stefaniuk, P. Stopa, S. Ghazaryan, Pavel A. Belov, Philipp Henkenjohann, Hannes Jung, O. Zenaiev, Aharon Levy, J. Grebenyuk, Robert Klanner, L. M. Shcheglova, H. U. Martyn, Matthias Klein, L. Stanco, I. Kadenko, Ie. Korol, Roland Horisberger, A. Valkárová, Sebastian Mergelmeyer, R. Žlebčík, O. Kononenko, F. Mohamad Idris, P. E. Reimer, Alan Campbell, N. Kondrashova, I. A. Korzhavina, W. Perlanski, Karel Cerny, Roman Kogler, Danuta Kisielewska, A. Behrendt Dubak, D. Salek, Peter Robmann, R. Brugnera, Yu.O. Shyrma, N. Zakharchuk, Kerstin Borras, S. Schmitt, B. B. Levchenko, Andrii Gizhko, P. Roloff, M. Kapichine, B. Foster, S. Dusini, T. Tsurugai, C. Niebuhr, Yu. A. Golubkov, E. Paul, K. Wichmann, M. Adamus, A.S. Belousov, C. Pascaud, C. Vallée, A. Lebedev, U. Karshon, Sergey Rusakov, P. Truöl, Grzegorz Nowak, R. Shevchenko, A. Longhin, B. Stella, V. Dodonov, L. K. Gladilin, R. K. Dementiev, J. G. Contreras, Orel Gueta, Andrii Verbytskyi, Mariusz Przybycien, M. Corradi, O. Viazlo, B. Tseepeldorj, S. Egli, G. Gach, A. Bruni, V. Andreev, Marta Ruspa, E.G. Boos, M. Jacquet, N. Z. Jomhari, M. Steder, Andreas Meyer, Vladyslav Libov, Marco Schioppa, J. Ciborowski, Y. Aushev, Y. Soloviev, V. Spaskov, A. M. Fomenko, W. B. Schmidke, J. Hladkỳ, Enrico Tassi, Laurent Schoeffel, Murrough Landon, W. A. T. Wan Abdullah, Katerina Lipka, Masaki Ishitsuka, Paul Laycock, E. Malinovski, O. Shkola, Emmanuelle Perez, R. C. W. Henderson, J. E. Olsson, Ian Brock, W. Słomiński, Ulf Behrens, H. Kowalski, Elisabetta Gallo, D. Lontkovskyi, M. Fleischer, R. Walczak, Emmanuel Sauvan, D. Notz, G. Grindhammer, D. Britzger, Yu. Onishchuk, Voica Radescu, A. Trofymov, Dirk L. Hoffmann, Christoph Grab, J. Turnau, K. Begzsuren, S. Yamada, D.S. Zotkin, T. Greenshaw, C. D. Catterall, J. Cvach, Manjit Kaur, E. Elsen, Laurent Favart, Natasa Raicevic, Vincent Boudry, A. Grebenyuk, J. Katzy, J. Feltesse, D. H. Saxon, Wolfgang Lange, I. Abt, I. Tsakov, N. Zhmak, A. Specka, A. Nikiforov, David M. South, Uta Klein, Nataliia Kovalchuk, B. Krupa, H. Pirumov, P. Sopicki, Stephen Maxfield, Dave Sankey, A. N. Morozov, Leszek Adamczyk, Ganna Dolinska, V. Brisson, J. Ferencei, J. Malka, Y. Vazdik, Cristinel Diaconu, A. Baghdasaryan, S. Kananov, A. Rostovtsev, D. Szuba, A. Garfagnini, P. Van Mechelen, Gy. Wolf, N.S. Pokrovskiy, Allen Caldwell, W. Hain, P. D. Thompson, N. Gogitidze, T. Ravdandorj, Claus Kleinwort, Amanda Cooper-Sarkar, E. Rizvi, G. D. Patel, Biljana Antunović, Federico Alberto Ceccopieri, J. Gayler, B.O. Zhautykov, Takuya Nobe, Katsuo Tokushuku, Zainol Abidin Ibrahim, P. Kostka, E. Lobodzinska, D. Wegener, T. Tymieniecka, D. Krücker, O. Yu. Lukina, Tomas Sykora, M. Sauter, Yuji Yamazaki, V. Myronenko, U. Kötz, Halina Abramowicz, M. Kuze, D. Haidt, A. Bylinkin, I. Rubinsky, E. Lohrmann, Aleksander Filip Żarnecki, H. J. Meyer, A. Bertolin, Thomas Schörner-Sadenius, Janusz Chwastowski, Ingo Bloch, R. J. Nowak, A. Buniatyan, S. Mikocki, L. Zawiejski, M. Turcato, Z. P. Zhang, E. Wünsch, I. Gregor, K. Daum, R. Roosen, Kunihiro Nagano, K. B. Cantun Avila, C. Kiesling, K. Müller, Monica Dobre, I. Picuric, P. Kaur, Guenter Eckerlin, J. Sztuk-Dambietz, André Schöning, Th. Naumann, O. Turkot, P. Pahl, E. Gabathuler, R. Hori, I. Makarenko, L. Goerlich, N. H. Brook, D. Traynor, Ankita Mehta, Daniel Pitzl, Y. Iga, O. Kuprash, Jan Figiel, S. Levonian, I. O. Skillicorn, A. Iudin, M. Lisovyi, F. Sefkow, Marcin Pawel Guzik, U. Schneekloth, Jan Kretzschmar, D. Hochman, P. J. Bussey, R. Ciesielski, J-P. Meyer, Olaf Behnke, Maxime Gouzevitch, Matthew Wing, J. B. Dainton, Gerhard Brandt, J. Tomaszewska, Xavier Janssen, A. Petrukhin, Benno List, Katja Krüger, A. Stern, A. V. Fedotov, Paul Newman, Achim Geiser, U. Straumann, L. Bystritskaya, V. Aushev, S. Antonelli, N. Muhammad Nasir, H. Zohrabyan, V. Chekelian, B. Löhr, B. Lobodzinski, Ada Solano, S. Limentani, I. Singh, B. Pokorny, Francois Corriveau, A. Kotański, J. Žáček, F. Huber, S. Shushkevich, Marcella Capua, and Tomas Hreus

Subjects
Quantum chromodynamics, Physics, Particle physics, Physics and Astronomy (miscellaneous), Engineering (miscellaneous), High Energy Physics::Phenomenology, Order (ring theory), Parton, HERA, Inelastic scattering, Deep inelastic scattering, Nuclear physics, Distribution function, Production (computer science), High Energy Physics::Experiment
Abstract

A combination is presented of all inclusive deep inelastic cross sections previously published by the H1 and ZEUS collaborations at HERA for neutral and charged current $e^{\pm}p$ scattering for zero beam polarisation. The data were taken at proton beam energies of 920, 820, 575 and 460 GeV and an electron beam energy of 27.5 GeV. The data correspond to an integrated luminosity of about 1 fb$^{-1}$ and span six orders of magnitude in negative four-momentum-transfer squared, $Q^2$, and Bjorken $x$. The correlations of the systematic uncertainties were evaluated and taken into account for the combination. The combined cross sections were input to QCD analyses at leading order, next-to-leading order and at next-to-next-to-leading order, providing a new set of parton distribution functions, called HERAPDF2.0. In addition to the experimental uncertainties, model and parameterisation uncertainties were assessed for these parton distribution functions. Variants of HERAPDF2.0 with an alternative gluon parameterisation, HERAPDF2.0AG, and using fixed-flavour-number schemes, HERAPDF2.0FF, are presented. The analysis was extended by including HERA data on charm and jet production, resulting in the variant HERAPDF2.0Jets. The inclusion of jet-production cross sections made a simultaneous determination of these parton distributions and the strong coupling constant possible, resulting in $\alpha_s(M_Z)=0.1183 \pm 0.0009 {\rm(exp)} \pm 0.0005{\rm (model/parameterisation)} \pm 0.0012{\rm (hadronisation)} ^{+0.0037}_{-0.0030}{\rm (scale)}$. An extraction of $xF_3^{\gamma Z}$ and results on electroweak unification and scaling violations are also presented.

Published
2015

32. Formation of arenicin-1 microdomains in bilayers and their specific lipid interaction revealed by Z-scan FCS

Author

Martin Hof, Radek Macháň, Jan Sýkora, Maxim N. Zhmak, Tatsiana Chernovets, and Tatiana V. Ovchinnikova

Subjects
chemistry.chemical_classification, Bilayer, Lipid Bilayers, Lipid microdomain, Analytical chemistry, Fluorescence correlation spectroscopy, Peptide, Lipids, Models, Biological, Biochemistry, Oligomer, Analytical Chemistry, Diffusion, chemistry.chemical_compound, Spectrometry, Fluorescence, Membrane, chemistry, Biophysics, lipids (amino acids, peptides, and proteins), Z-scan technique, Lipid bilayer, Antimicrobial Cationic Peptides
Abstract

Z-scan fluorescence correlation spectroscopy (FCS) is employed to characterize the interaction between arenicin-1 and supported lipid bilayers (SLBs) of different compositions. Lipid analogue C8-BODIPY 500/510C5-HPC and ATTO 465 labelled arenicin-1 are used to detect changes in lipid and peptide diffusion upon addition of unlabelled arenicin-1 to SLBs. Arenicin-1 decreases lipid mobility in negatively charged SLBs. According to diffusion law analysis, microdomains of significantly lower lipid mobility are formed. The analysis of peptide FCS data confirms the presence of microdomains for anionic SLBs. No indications of microdomain formation are detected in SLBs composed purely of zwitterionic lipids. Additionally, our FCS results imply that arenicin-1 exists in the form of oligomers and/or aggregates when interacting with membranes of both compositions.

Published
2011

33. Inclusive-jet cross sections in NC DIS at HERA and a comparison of the kT, anti-kT and SIScone jet algorithms

Author

H. Abramowicz, I. Abt, L. Adamczyk, M. Adamus, R. Aggarwal, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, V. Aushev, Y. Aushev, O. Bachynska, A. Bamberger, A.N. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, D. Bartsch, M. Basile, O. Behnke, J. Behr, U. Behrens, L. Bellagamba, A. Bertolin, S. Bhadra, M. Bindi, C. Blohm, T. Bołd, E.G. Boos, M. Borodin, K. Borras, D. Boscherini, D. Bot, S.K. Boutle, I. Brock, E. Brownson, R. Brugnera, N. Brümmer, A. Bruni, G. Bruni, B. Brzozowska, P.J. Bussey, J.M. Butterworth, B. Bylsma, A. Caldwell, M. Capua, R. Carlin, C.D. Catterall, S. Chekanov, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, A.M. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, G. D'Agostini, F. Dal Corso, J. de Favereau, J. del Peso, R.K. Dementiev, S. De Pasquale, M. Derrick, R.C.E. Devenish, D. Dobur, B.A. Dolgoshein, A.T. Doyle, V. Drugakov, L.S. Durkin, S. Dusini, Y. Eisenberg, P.F. Ermolov, A. Eskreys, S. Fang, S. Fazio, J. Ferrando, M.I. Ferrero, J. Figiel, M. Forrest, B. Foster, S. Fourletov, G. Gach, A. Galas, E. Gallo, A. Garfagnini, A. Geiser, I. Gialas, L.K. Gladilin, D. Gladkov, C. Glasman, O. Gogota, Yu.A. Golubkov, P. Göttlicher, I. Grabowska-Bołd, J. Grebenyuk, I. Gregor, G. Grigorescu, G. Grzelak, C. Gwenlan, T. Haas, W. Hain, R. Hamatsu, J.C. Hart, H. Hartmann, G. Hartner, E. Hilger, D. Hochman, U. Holm, R. Hori, K. Horton, A. Hüttmann, G. Iacobucci, Z.A. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, H.-P. Jakob, F. Januschek, M. Jimenez, T.W. Jones, M. Jüngst, I. Kadenko, B. Kahle, B. Kamaluddin, S. Kananov, T. Kanno, U. Karshon, F. Karstens, I.I. Katkov, M. Kaur, P. Kaur, A. Keramidas, L.A. Khein, J.Y. Kim, D. Kisielewska, S. Kitamura, R. Klanner, U. Klein, E. Koffeman, D. Kollar, P. Kooijman, Ie. Korol, I.A. Korzhavina, A. Kotański, U. Kötz, H. Kowalski, P. Kulinski, O. Kuprash, M. Kuze, V.A. Kuzmin, A. Lee, B.B. Levchenko, A. Levy, V. Libov, S. Limentani, T.Y. Ling, M. Lisovyi, E. Lobodzinska, W. Lohmann, B. Löhr, E. Lohrmann, J.H. Loizides, K.R. Long, A. Longhin, D. Lontkovskyi, O.Yu. Lukina, P. Łużniak, J. Maeda, S. Magill, I. Makarenko, J. Malka, R. Mankel, A. Margotti, G. Marini, J.F. Martin, A. Mastroberardino, T. Matsumoto, M.C.K. Mattingly, I.-A. Melzer-Pellmann, S. Miglioranzi, F. Mohamad Idris, V. Monaco, A. Montanari, J.D. Morris, B. Musgrave, K. Nagano, T. Namsoo, R. Nania, D. Nicholass, A. Nigro, Y. Ning, U. Noor, D. Notz, R.J. Nowak, A.E. Nuncio-Quiroz, B.Y. Oh, N. Okazaki, K. Oliver, K. Olkiewicz, Yu. Onishchuk, O. Ota, K. Papageorgiu, A. Parenti, E. Paul, J.M. Pawlak, B. Pawlik, P.G. Pelfer, A. Pellegrino, W. Perlanski, H. Perrey, K. Piotrzkowski, P. Plucinski, N.S. Pokrovskiy, A. Polini, A.S. Proskuryakov, M. Przybycień, A. Raval, D.D. Reeder, B. Reisert, Z. Ren, J. Repond, Y.D. Ri, A. Robertson, P. Roloff, E. Ron, I. Rubinsky, M. Ruspa, R. Sacchi, A. Salii, U. Samson, G. Sartorelli, A.A. Savin, D.H. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W.B. Schmidke, U. Schneekloth, V. Schönberg, T. Schörner-Sadenius, J. Schwartz, F. Sciulli, L.M. Shcheglova, R. Shehzadi, S. Shimizu, I. Singh, I.O. Skillicorn, W. Słomiński, W.H. Smith, V. Sola, A. Solano, D. Son, V. Sosnovtsev, A. Spiridonov, H. Stadie, L. Stanco, A. Stern, T.P. Stewart, A. Stifutkin, P. Stopa, S. Suchkov, G. Susinno, L. Suszycki, J. Sztuk, D. Szuba, J. Szuba, A.D. Tapper, E. Tassi, J. Terrón, T. Theedt, H. Tiecke, K. Tokushuku, O. Tomalak, J. Tomaszewska, T. Tsurugai, M. Turcato, T. Tymieniecka, C. Uribe-Estrada, M. Vázquez, A. Verbytskyi, V. Viazlo, N.N. Vlasov, O. Volynets, R. Walczak, W.A.T. Wan Abdullah, J.J. Whitmore, J. Whyte, L. Wiggers, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, A.G. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, A.F. Żarnecki, L. Zawiejski, O. Zenaiev, W. Zeuner, B.O. Zhautykov, N. Zhmak, C. Zhou, A. Zichichi, M. Zolko, D.S. Zotkin, and Z. Zulkapli

Subjects
Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Particle physics, Jet (fluid), ZEUS (particle detector), 010308 nuclear & particles physics, Elementary particle, HERA, Inelastic scattering, Deep inelastic scattering, 01 natural sciences, Particle identification, Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, 010306 general physics, Algorithm
Abstract

For the first time, differential inclusive-jet cross sections have been measured in neutral current deep inelastic ep scattering using the anti-k(T) and SIScone algorithms. The measurements were made for boson virtualities Q(2) > 125 GeV2 with the ZEUS detector at HERA using an integrated luminosity of 82 pb(-1) and the jets were identified in the Breit frame. The performance and suitability of the jet algorithms for their use in hadron-like reactions were investigated by comparing the measurements to those performed with the k(T) algorithm. Next-to-leading-order QCD calculations give a good description of the measurements. Measurements of the ratios of cross sections using different jet algorithms are also presented; the measured ratios are well described by calculations including up to O(alpha(3)(s)) terms. Values of alpha(s)(M-z) were extracted from the data; the results are compatible with and have similar precision to the value extracted from the kT analysis. (C) 2010 Elsevier B.V. All rights reserved.

Published
2010

34. Synthetic analogues of antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi

Author

E. V. Grishin, Dubovskiĭ Pv, Vasilevskiĭ Aa, Shaturskiĭ OIa, S. A. Kozlov, Kudelina Ia, Maxim N. Zhmak, and Arsen'ev As

Subjects
chemistry.chemical_classification, Membrane, chemistry, Biochemistry, Organic Chemistry, Antimicrobial peptides, Amphiphile, Bioorganic chemistry, Biological activity, Venom, Peptide, Amino acid
Abstract

Analogues of latarcins Ltc1 and Ltc3b, antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi capable of formation of amphiphilic structures in membranes without involvement of disulfide bonds, were synthesized. The amino acid sequences of the analogues correspond to immature forms of these peptides, each of them containing an additional C-terminal amino acid residue. It is concluded from the study of the biological activity of the synthesized peptides that the posttranslational C-terminal amidation of Ltc3b is a functionally important modification that ensures a high activity of the mature peptide. The lipid composition was shown to affect the interaction of synthesized peptides with artificial membranes. The analogue of Ltc3b manifested the highest activity on cholesterol-containing membranes. The mechanism of action of the studied antimicrobial peptides on membranes is discussed.

Published
2007

35. Combination of differential D∗± cross-section measurements in deep-inelastic ep scattering at HERA

Author

C. Vallée, A. Lebedev, A. Bruni, W. B. Schmidke, R.C.E. Devenish, F. Mohamad Idris, D. P. C. Sankey, N. Muhammad Nasir, Andrii Gizhko, N. Kondrashova, Enrico Tassi, P. E. Reimer, P. Roloff, M. Kapichine, Alan Campbell, U. Karshon, D. Notz, I. Kadenko, N. Stefaniuk, L. M. Shcheglova, Ie. Korol, D.S. Zotkin, I. A. Korzhavina, H. U. Martyn, Y. Soloviev, V. Andreev, B. B. Levchenko, J. Szuba, Takuya Nobe, P. D. Thompson, K. Daum, David M. South, J. Cvach, Uta Klein, J. Feltesse, L. Stanco, V. Chekelian, A. V. Fedotov, A. Baghdasaryan, Paul Laycock, E. Malinovski, Emmanuel Sauvan, G. Grindhammer, Nataliia Kovalchuk, A. Rostovtsev, Fabian Zomer, R. Hori, I. Makarenko, Y. Iga, O. Shkola, B. Löhr, Wolfgang Lange, P. Stopa, D. Wegener, Leszek Adamczyk, B. Krupa, V. Dodonov, Max Klein, D. Traynor, I. O. Skillicorn, J. Gayler, Robert Ciesielski, I. Abt, Tomas Sykora, M. Sauter, E.G. Boos, Karel Cerny, M. Jacquet, E. Rizvi, G. D. Patel, B. Lobodzinski, Yuji Yamazaki, Laurent Schoeffel, O. Yu. Lukina, A. Longhin, Masaki Ishitsuka, Elisabetta Gallo, Yu. Onishchuk, W. Słomiński, Ulf Behrens, H. Kowalski, Roman Kogler, Grzegorz Nowak, S. Egli, L. Bystritskaya, M. Steder, A. Garfagnini, D. Lontkovskyi, Andreas Meyer, A. Grebenyuk, H. J. Meyer, W. Hain, Ada Solano, G. Grzelak, Jenny List, E. Lobodzinska, N. Z. Jomhari, Peter Robmann, M. Fleischer, H. Zohrabyan, Emmanuelle Perez, D. Britzger, M. P. J. Landon, P. Van Mechelen, Dirk L. Hoffmann, Marina Rotaru, F. Januschek, Peter Bussey, Voica Radescu, Christoph Grab, A. Trofymov, Thomas Schörner-Sadenius, W. A. T. Wan Abdullah, N.S. Pokrovskiy, I. Gregor, S. Limentani, R. Shevchenko, S. Kananov, Benno List, O. Kononenko, S. Mikocki, Jean-Arcady Meyer, Z. P. Zhang, D. Ozerov, Paul Newman, Achim Geiser, R. Brugnera, Yu.O. Shyrma, Kerstin Borras, Katja Krüger, R. C. W. Henderson, K. Müller, Sebastian Mergelmeyer, I. Singh, T. Tsurugai, C. Niebuhr, B. Tseepeldorj, A. Stern, R. Žlebčík, Stephen Maxfield, V. Aushev, Andreas Werner Jung, U. Straumann, S. Antonelli, Y. Aushev, D. Szuba, Andrew Mehta, K. Wichmann, M. Adamus, Richard Polifka, B. Pokorny, N. Gogitidze, Katerina Lipka, P. Sopicki, A.S. Belousov, E. Elsen, S. Ghazaryan, Sergey Rusakov, Ganna Dolinska, P. Truöl, A. Specka, V. Brisson, Jan Hladky, V. Myronenko, Allen Caldwell, Federico Alberto Ceccopieri, Francois Corriveau, A. Kotański, B. Foster, Zainol Abidin Ibrahim, P. Kostka, T. Greenshaw, S. Dusini, O. Kuprash, Cristinel Diaconu, T. Tymieniecka, Halina Abramowicz, Robert Klanner, A. Iudin, Jan Figiel, U. Kötz, J. Tomaszewska, Katsuo Tokushuku, L. K. Gladilin, R. K. Dementiev, J. Žáček, M. Lisovyi, F. Huber, J. E. Olsson, A. M. Cooper-Sarkar, R. J. Nowak, J. Ferencei, Yu. A. Golubkov, E. Paul, S. Shushkevich, Marcella Capua, Tomas Hreus, N. Zhmak, Gy. Wolf, Janusz Chwastowski, T. Ravdandorj, R. Roosen, Claus Kleinwort, Natasa Raicevic, Monica Dobre, Vincent Boudry, M. Kuze, A. N. Morozov, Mariusz Przybycien, M. Corradi, O. Viazlo, S. Schmitt, E. Lohrmann, Gerhard Brandt, V. Spaskov, E. Wünsch, Grzegorz Gach, B.O. Zhautykov, Daniel Pitzl, Marcin Pawel Guzik, U. Schneekloth, Jan Kretzschmar, A. Bertolin, A. Buniatyan, I. Rubinsky, Ingo Bloch, Roland Horisberger, L. Zawiejski, A. Valkárová, W. Perlanski, M. Turcato, Kunihiro Nagano, K. B. Cantun Avila, Xavier Janssen, A. Petrukhin, J. Turnau, C. Kiesling, K. Begzsuren, S. Yamada, I. Tsakov, P. Kaur, Olaf Behnke, Alexander Bylinkin, J. Ciborowski, Manjit Kaur, J. Malka, Roman Walczak, Y. Vazdik, J. Sztuk-Dambietz, Th. Naumann, O. Turkot, P. Pahl, E. Gabathuler, M. Gouzevitch, D. Salek, J. G. Contreras, Orel Gueta, Andrii Verbytskyi, Marta Ruspa, Aharon Levy, Vladyslav Libov, C.D. Catterall, Ian Brock, Laurent Favart, D. H. Saxon, S. Levonian, F. Sefkow, D. Haidt, Aleksander Filip Żarnecki, I. Picuric, Guenter Eckerlin, André Schöning, L. Goerlich, N. H. Brook, Danuta Kisielewska, R. Plačakytė, A. M. Fomenko, N. Zakharchuk, Marco Schioppa, H. Pirumov, D. Hochman, Hannes Jung, O. Zenaiev, J. Grebenyuk, Matthew Wing, J. B. Dainton, C. Pascaud, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), H1, ZEUS, H1 Collaboration, and ZEUS Collaboration

Subjects
electron, Particle physics, Nuclear and High Energy Physics, Meson, Lepton-Nucleon Scattering, HERA, heavy quark production, FOS: Physical sciences, transverse momentum, meson, High Energy Physics - Experiment, Nuclear physics, Cross section (physics), High Energy Physics - Experiment (hep-ex), phase space, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, quantum chromodynamics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Rapidity, ddc:530, Nuclear Experiment, QCD, Heavy quark production, Charm physics, charm physics, Physics, Quantum chromodynamics, ZEUS (particle detector), Scattering, ZEUS, H1, scattering, photon, lepton-nucleon scattering, DESY HERA Stor, rapidity, kinematics, Pseudorapidity, correlation, deep inelastic scattering [electron p], High Energy Physics::Experiment, Particle Physics - Experiment
Abstract

H1 and ZEUS have published single-differential cross sections for inclusive D ∗±-meson production in deep-inelastic ep scattering at HERA from their respective final data sets. These cross sections are combined in the common visible phase-space region of photon virtuality Q 2 > 5 GeV2, electron inelasticity 0.02 < y < 0.7 and the D ∗± meson’s transverse momentum p T(D ∗) > 1.5 GeV and pseudorapidity |η(D ∗)| < 1.5. The combination procedure takes into account all correlations, yielding significantly reduced experimental uncertainties. Double-differential cross sections d2 σ/dQ 2dy are combined with earlier D ∗± data, extending the kinematic range down to Q 2 > 1.5 GeV2. Perturbative next-to-leading-order QCD predictions are compared to the results., Journal of High Energy Physics, 2015 (9), ISSN:1126-6708, ISSN:1029-8479

Published
2015

36. Measurement of charm fragmentation fractions in photoproduction at HERA

Author

Allen Caldwell, Zainol Abidin Ibrahim, M. Derrick, H.-P. Jakob, T. Tymieniecka, A. Parenti, U. Kötz, F. Mohamad Idris, R. Brugnera, R. Yoshida, R. J. Nowak, Kerstin Borras, A. Zichichi, D. Notz, A.G. Yagües-Molina, Ada Solano, J. M. Pawlak, A. Trofymov, K. Mujkic, D.S. Zotkin, R. Hori, Dong-Chul Son, C. D. Catterall, E. Hilger, S. Limentani, E.G. Boos, Takuya Nobe, A. Garfagnini, Krzysztof Piotrzkowski, O. Kononenko, Leszek Adamczyk, Alexander Spiridonov, I. A. Melzer-Pellmann, S. Fazio, Roberto Sacchi, Alessia Bruni, B.Y. Oh, R. Shevchenko, A. Longhin, Tobias M. Haas, U. Samson, C. Blohm, I. Singh, M.I. Ferrero, Aharon Levy, Fernando Barreiro, S. De Pasquale, F. Karstens, F. J. Sciulli, P.F. Ermolov, N.S. Pokrovskiy, A. Nigro, Mykhailo Lisovyi, A. T. Doyle, J. Sztuk-Dambietz, Zukhaimira Zolkapli, S.I. Suchkov, D.D. Reeder, F. Dal Corso, R.C.E. Devenish, O. Turkot, Kenneth Long, Ramoona Shehzadi, Massimo Corradi, I. Gialas, B. Kahle, G. Bari, Roberto Carlin, Didar Dobur, Rosario Nania, Denys Lontkovskyi, Francois Corriveau, L. Cifarelli, Jose Repond, James Ferrando, J. Maeda, B.O. Zhautykov, A. Kotański, Y. Aushev, Alessandro Montanari, Alexander Tapper, S. Magill, Marcello Bindi, B. Pawlik, W. H. Smith, Ganna Dolinska, Ozan Arslan, N. Kovalchuk, Nazar Bartosik, Enrico Tassi, John Hart, Mário Costa, J. J. Whitmore, J. Malka, M. Jüngst, Ben Bylsma, D. Szuba, G. Hartner, Y. Ning, N. Brümmer, Katsuo Tokushuku, A. E. Nuncio-Quiroz, W. A. T. Wan Abdullah, D. Bot, A. Pellegrino, M.C.K. Mattingly, L. S. Durkin, Ewelina Lobodzinska, T. Tsurugai, J. Schwartz, Robert Ciesielski, G. Grzelak, H. Hartmann, Valentina Sola, A. N. Barakbaev, V. Bokhonov, Giuseppe Barbagli, I. Makarenko, M. Wlasenko, Andrii Gizhko, Janusz Chwastowski, U. Karshon, Oleg Kuprash, Masahiro Kuze, U. Schneekloth, Lorenzo Bellagamba, Claudia Glasman, T. Schörner-Sadenius, Y. Iga, K. Olkiewicz, R. Hamatsu, O. Bachynska, Els Koffeman, Peter Schleper, Claire Gwenlan, P. Göttlicher, Iwona Grabowska-Bold, B. B. Levchenko, F. Januschek, S. Kitamura, H. Wolfe, O. Behnke, I. O. Skillicorn, N. Coppola, I. Rubinsky, Andrea Contin, Vladyslav Libov, R. Mankel, Wolfgang Lohmann, G. Susinno, L. Suszycki, V. Drugakov, J. Szuba, K. Wichmann, M. Adamus, G. Marini, Wolfram Dietrich Zeuner, E. Lohrmann, A. Bamberger, Halina Abramowicz, A. Stern, A.S. Proskuryakov, J. F. Martin, Lev Khein, Graziano Bruni, L. M. Shcheglova, Hartmut Stadie, Ian Brock, Grzegorz Gach, Uta Klein, D. Gladkov, T. W. Jones, Jan Figiel, S. Yamada, Yu. A. Golubkov, E. Paul, S. Kananov, Guenter Wolf, H.G.J.M. Tiecke, I. Kadenko, A. Iudin, G. Grigorescu, Marcella Capua, L. Stanco, R. Ingbir, Shinichi Shimizu, A.G. Robertson, N. Vlasov, B. Brzozowska, P. Stopa, Mariusz Przybycien, O. Viazlo, O. Yu. Lukina, B. Reisert, Tomasz Bold, A. Hüttmann, D. H. Saxon, Yuji Yamazaki, Igor Katkov, P.M. Kooijman, Achim Geiser, J. Tomaszewska, V. Myronenko, V. Sosnovtsev, S. Fang, Sebastian Mergelmeyer, Nazar Stefaniuk, Anselmo Margotti, J. Grebenyuk, L.W. Wiggers, Juan Terron, Marco Schioppa, P. G. Pelfer, Marcin Pawel Guzik, W. Słomiński, Ulf Behrens, Federico Cindolo, H. Kowalski, Hanno Perrey, S. Antonelli, V. Trusov, R. Aggarwal, Ingrid-Maria Gregor, Anna Mastroberardino, Ie. Korol, O. Gogota, Elisabetta Gallo, Amanda Cooper-Sarkar, Yu. Onishchuk, T. Theedt, I. A. Korzhavina, V. Schönberg, N. Kondrashova, W. B. Schmidke, O. Zenaiev, E. Brownson, Michele Arneodo, Orel Gueta, Andrii Verbytskyi, Marta Ruspa, K. Papageorgiu, W. Perlanski, S. Bhadra, N. Okazaki, Masaki Ishitsuka, John Morris, Peter Bussey, B. Löhr, K. Wrona, B. Foster, S. Dusini, J. Y. Kim, Pietro Antonioli, R. K. Dementiev, A. Eskreys, Janna Katharina Behr, M. Vázquez, N. Zhmak, Pawel Plucinski, T. Namsoo, J. Del Peso, G. D'Agostini, T. Y. Ling, V. Aushev, Robert Klanner, Y. Eisenberg, I. Abt, Sergei Chekanov, Boris Dolgoshein, Dirk-Uwe Bartsch, Y. D. Ri, A. Lee, V. Monaco, M. Basile, G. Sartorelli, W. Hain, S. Miglioranzi, A. Raval, Danuta Kisielewska, D. Hochman, S. Schlenstedt, T. P. Stewart, C. Youngman, O. Shkola, Alessandro Polini, N. Zakharchuk, Philipp Roloff, J. Ciborowski, Alexey Antonov, Manjit Kaur, Leonid Gladilin, Roman Walczak, Davide Boscherini, Matthew Wing, Zhongliang Ren, A. Keramidas, A. Bertolin, A. Galas, Aleksander Filip Żarnecki, L. Zawiejski, M. Turcato, Kunihiro Nagano, B. Musgrave, P. Kaur, A. Stifutkin, T. Kanno, Alexander Savin, H. Abramowicz, I. Abt, L. Adamczyk, M. Adamu, R. Aggarwal, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, O. Arslan, V. Aushev, Y. Aushev, O. Bachynska, A. Bamberger, A.N. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, N. Bartosik, D. Bartsch, M. Basile, O. Behnke, J. Behr, U. Behren, L. Bellagamba, A. Bertolin, S. Bhadra, M. Bindi, C. Blohm, V. Bokhonov, T. Bold, E.G. Boo, K. Borra, D. Boscherini, D. Bot, I. Brock, E. Brownson, R. Brugnera, N. Brümmer, A. Bruni, G. Bruni, B. Brzozowska, P.J. Bussey, B. Bylsma, A. Caldwell, M. Capua, R. Carlin, C.D. Catterall, S. Chekanov, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, A.M. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, G. D’Agostini, F. Dal Corso, J. Peso, R.K. Dementiev, S. Pasquale, M. Derrick, R.C.E. Devenish, D. Dobur, B.A. Dolgoshein, G. Dolinska, A.T. Doyle, V. Drugakov, L.S. Durkin, S. Dusini, Y. Eisenberg, P.F. Ermolov, A. Eskrey, S. Fang, S. Fazio, J. Ferrando, M.I. Ferrero, J. Figiel, B. Foster, G. Gach, A. Gala, E. Gallo, A. Garfagnini, A. Geiser, I. Giala, A. Gizhko, L.K. Gladilin, D. Gladkov, C. Glasman, O. Gogota, Yu.A. Golubkov, P. Göttlicher, I. Grabowska-Bold, J. Grebenyuk, I. Gregor, G. Grigorescu, G. Grzelak, O. Gueta, M. Guzik, C. Gwenlan, T. Haa, W. Hain, R. Hamatsu, J.C. Hart, H. Hartmann, G. Hartner, E. Hilger, D. Hochman, R. Hori, A. Hüttmann, Z.A. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, A. Iudin, H.-P. Jakob, F. Januschek, T.W. Jone, M. Jüngst, I. Kadenko, B. Kahle, S. Kananov, T. Kanno, U. Karshon, F. Karsten, I.I. Katkov, M. Kaur, P. Kaur, A. Keramida, L.A. Khein, J.Y. Kim, D. Kisielewska, S. Kitamura, R. Klanner, U. Klein, E. Koffeman, N. Kondrashova, O. Kononenko, P. Kooijman, Ie. Korol, I.A. Korzhavina, A. Kotanski, U. Kötz, N. Kovalchuk, H. Kowalski, O. Kuprash, M. Kuze, A. Lee, B.B. Levchenko, A. Levy, V. Libov, S. Limentani, T.Y. Ling, M. Lisovyi, E. Lobodzinska, W. Lohmann, B. Löhr, E. Lohrmann, K.R. Long, A. Longhin, D. Lontkovskyi, O.Yu. Lukina, J. Maeda, S. Magill, I. Makarenko, J. Malka, R. Mankel, A. Margotti, G. Marini, J.F. Martin, A. Mastroberardino, M.C.K. Mattingly, I.-A. Melzer-Pellmann, S. Mergelmeyer, S. Miglioranzi, F. Mohamad Idri, V. Monaco, A. Montanari, J.D. Morri, K. Mujkic, B. Musgrave, V. Myronenko, K. Nagano, T. Namsoo, R. Nania, A. Nigro, Y. Ning, T. Nobe, D. Notz, R.J. Nowak, A.E. Nuncio-Quiroz, B.Y. Oh, N. Okazaki, K. Olkiewicz, Yu. Onishchuk, K. Papageorgiu, A. Parenti, E. Paul, J.M. Pawlak, B. Pawlik, P. G. Pelfer, A. Pellegrino, W. Perlanski, H. Perrey, K. Piotrzkowski, P. Plucinski, N.S. Pokrovskiy, A. Polini, A.S. Proskuryakov, M. Przybycien, A. Raval, D.D. Reeder, B. Reisert, Z. Ren, J. Repond, Y.D. Ri, A. Robertson, P. Roloff, I. Rubinsky, M. Ruspa, R. Sacchi, U. Samson, G. Sartorelli, A.A. Savin, D.H. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W.B. Schmidke, U. Schneekloth, V. Schönberg, T. Schörner-Sadeniu, J. Schwartz, F. Sciulli, L.M. Shcheglova, R. Shehzadi, R. Shevchenko, S. Shimizu, O. Shkola, I. Singh, I.O. Skillicorn, W. Slominski, W.H. Smith, V. Sola, A. Solano, D. Son, V. Sosnovtsev, A. Spiridonov, H. Stadie, L. Stanco, N. Stefaniuk, A. Stern, T.P. Stewart, A. Stifutkin, P. Stopa, S. Suchkov, G. Susinno, L. Suszycki, J. Sztuk-Dambietz, D. Szuba, J. Szuba, A.D. Tapper, E. Tassi, J. Terrón, T. Theedt, H. Tiecke, K. Tokushuku, J. Tomaszewska, A. Trofymov, V. Trusov, T. Tsurugai, M. Turcato, O. Turkot, T. Tymieniecka, M. Vázquez, A. Verbytskyi, O. Viazlo, N.N. Vlasov, R. Walczak, W.A.T. Wan Abdullah, J.J. Whitmore, K. Wichmann, L. Wigger, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, A.G. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, N. Zakharchuk, A.F. Żarnecki, L. Zawiejski, O. Zenaiev, W. Zeuner, B.O. Zhautykov, N. Zhmak, A. Zichichi, Z. Zolkapli, D.S. Zotkin, and Zeus (IHEF, IoP, FNWI)

Subjects
Nuclear and High Energy Physics, Antiparticle, Particle physics, Meson, Hadron, Nuclear Theory, Lepton-Nucleon Scattering, HERA, FOS: Physical sciences, 7. Clean energy, 01 natural sciences, lepton-nucleon scattering, charm physics, qcd, Charm quark, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), QCD, Charm physics, High Energy Physics, ZEUS Collaboration, 0103 physical sciences, ddc:530, Rapidity, 010306 general physics, Nuclear Experiment, Physics, Quantum chromodynamics, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Pseudorapidity, High Energy Physics::Experiment
Abstract

The production of D^0, D^*+, D^+, D_s+ and Lambda_c^+ charm hadrons and their antiparticles in ep scattering at HERA has been studied with the ZEUS detector, using a total integrated luminosity of 372 pb^-1. The fractions of charm quarks hadronising into a particular charm hadron were derived. In addition, the ratio of neutral to charged D-meson production rates, the fraction of charged D mesons produced in a vector state, and the stangeness-suppression factor have been determined. The measurements have been performed in the photoproduction regime. The charm hadrons were reconstructed in the range of transverse momentum p_T >3.8 GeV and pseudorapidity |eta, 27 pages, 6 figures

Published
2013

37. Measurement of D*± production in deep inelastic scattering at HERA

Author

B. B. Levchenko, J. F. Martin, D. Gladkov, Guenter Wolf, B. Brzozowska, S. Bhadra, F. Dal Corso, Ewelina Lobodzinska, Andrii Gizhko, U. Karshon, U. Schneekloth, D. Boscherini, G. Susinno, M. Wlasenko, Af Zarnecki, E. Hilger, A.G. Robertson, Mariusz Przybycien, M. Corradi, O. Viazlo, Hanno Perrey, Katsuo Tokushuku, S. Fang, J. Ciborowski, Sebastian Mergelmeyer, S. Kitamura, H.-P. Jakob, I. Gialas, E.G. Boos, I. Abt, N. Kondrashova, Elisabetta Gallo, Yu. Onishchuk, F. J. Sciulli, M. Jüngst, Ben Bylsma, D. Szuba, Janusz Chwastowski, Francois Corriveau, V. Monaco, B.Y. Oh, L. Cifarelli, R. Brugnera, Kerstin Borras, T. Namsoo, Takuya Nobe, A. Longhin, A.G. Yagües-Molina, Dong-Chul Son, Manjit Kaur, A. Kotański, W. Hain, A. M. Cooper-Sarkar, G. Hartner, I. M. Gregor, Roman Walczak, A. E. Nuncio-Quiroz, W. A. T. Wan Abdullah, T. Theedt, O. Kononenko, Alexander Tapper, S. De Pasquale, N.S. Pokrovskiy, Zukhaimira Zolkapli, A. Polini, H. Hartmann, Tobias M. Haas, D. Bot, Shoichi Yamada, M. Basile, R.C.E. Devenish, W. H. Smith, G. D'Agostini, P. Stopa, A. Nigro, Masaki Ishitsuka, Y. Ning, Anselmo Margotti, J. Grebenyuk, L.W. Wiggers, T. Schörner-Sadenius, J. Del Peso, K. Olkiewicz, W. B. Schmidke, Mykhailo Lisovyi, Zhongliang Ren, Halina Abramowicz, Allen Caldwell, Zainol Abidin Ibrahim, T. Tymieniecka, T. Y. Ling, O. Gogota, Robert Klanner, Ada Solano, V. Bokhonov, A. Parenti, U. Kötz, B. Löhr, C. Blohm, K. Papageorgiu, A. Eskreys, J. Sztuk-Dambietz, N. Brümmer, F. Mohamad Idris, H. Wolfe, R. Hori, K. Wrona, B. Foster, Hartmut Stadie, Kenneth Long, Yu. A. Golubkov, E. Paul, Fernando Barreiro, Iwona Grabowska-Bold, S. Miglioranzi, A. Raval, Danuta Kisielewska, S. Limentani, A. Antonov, S. Dusini, Michele Arneodo, R. J. Nowak, T. P. Stewart, T. Tsurugai, G. Bari, Marcello Bindi, B. Pawlik, C. Youngman, S.I. Suchkov, A. N. Barakbaev, R. Mankel, Wolfgang Lohmann, Pawel Plucinski, I. Singh, O. Turkot, Janna Katharina Behr, A. Zichichi, J. Maeda, Alexander Spiridonov, I. A. Melzer-Pellmann, W. Perlanski, J. Y. Kim, Pietro Antonioli, Giovanna Bruni, Uta Klein, A. Stern, D. Notz, L. K. Gladilin, R. K. Dementiev, Krzysztof Piotrzkowski, P. Göttlicher, A. Pellegrino, Didar Dobur, M.C.K. Mattingly, L. S. Durkin, M. Vázquez, V. Sosnovtsev, N. Zakharchuk, Ganna Dolinska, J. Repond, B. Kahle, N. Okazaki, Roberto Carlin, J. Malka, D.S. Zotkin, C. D. Catterall, T. W. Jones, Ozan Arslan, R. Hamatsu, Y. Aushev, O. Bachynska, Alessandro Montanari, Philipp Roloff, Marco Schioppa, Els Koffeman, John Morris, Ulf Behrens, P. G. Pelfer, Andrea Contin, Federico Cindolo, H. Kowalski, N. Kovalchuk, Valentina Sola, A. Keramidas, Peter Schleper, V. Aushev, A. Bertolin, Y. Eisenberg, L. Suszycki, O. Yu. Lukina, B. Reisert, V. Trusov, Marcella Capua, L. Zawiejski, K. Wichmann, M. Turcato, N. Coppola, Anna Mastroberardino, Kunihiro Nagano, Y. D. Ri, M. Adamus, G. Marini, N.N. Vlasov, Peter Bussey, S. Magill, P. Kaur, Wolfram Dietrich Zeuner, A. Bamberger, P.F. Ermolov, A. Galas, G. Sartorelli, Jan Figiel, Yuji Yamazaki, A. Stifutkin, Igor Katkov, A. Iudin, J. Tomaszewska, G. Grigorescu, L. M. Shcheglova, James Ferrando, L. Stanco, R. Ingbir, Nazar Stefaniuk, R. Yoshida, Claudia Glasman, V. Drugakov, Lev Khein, S. Kananov, B.O. Zhautykov, Marco Costa, John Hart, Oleg Kuprash, I. Rubinsky, A. Trofymov, J. M. Pawlak, K. Mujkic, A. Garfagnini, U. Samson, Rosario Nania, Giuseppe Barbagli, I. Makarenko, Y. Iga, I. O. Skillicorn, Marcin Pawel Guzik, R. Aggarwal, J. Schwartz, G. Grzelak, M. Kuze, E. Lohrmann, Grzegorz Gach, E. Brownson, A. T. Doyle, Claire Gwenlan, Matthew Wing, B. A. Dolgoshein, W. Slominski, F. Januschek, Orel Gueta, Andrii Verbytskyi, Marta Ruspa, S. Fazio, Roberto Sacchi, Leszek Adamczyk, Aharon Levy, V. Schönberg, Vladyslav Libov, D. Hochman, S. Schlenstedt, O. Zenaiev, Ian Brock, Sergei Chekanov, Dirk-Uwe Bartsch, A. Hüttmann, D. H. Saxon, A. Lee, L. Bellagamba, Tomasz Bold, Denys Lontkovskyi, A. Bruni, Robert Ciesielski, O. Behnke, Nazar Bartosik, Enrico Tassi, J. J. Whitmore, J. Szuba, A.S. Proskuryakov, M. Derrick, P.M. Kooijman, Achim Geiser, Juan Terron, B. Musgrave, S. Antonelli, M.I. Ferrero, F. Karstens, H.G.J.M. Tiecke, I. Kadenko, Shinichi Shimizu, Ie. Korol, I. A. Korzhavina, N. Zhmak, T. Kanno, Alexander Savin, D.D. Reeder, Ramoona Shehzadi, UAM. Departamento de Física Teórica, Zeus (IHEF, IoP, FNWI), H. Abramowicz, I. Abt, L. Adamczyk, M. Adamu, R. Aggarwal, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, O. Arslan, V. Aushev, Y. Aushev, O. Bachynska, A. Bamberger, A. N. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, N. Bartosik, D. Bartsch, M. Basile, O. Behnke, J. Behr, U. Behren, L. Bellagamba, A. Bertolin, S. Bhadra, M. Bindi, C. Blohm, V. Bokhonov, T. Bold, E. G. Boo, K. Borra, D. Boscherini, D. Bot, I. Brock, E. Brownson, R. Brugnera, N. Brümmer, A. Bruni, G. Bruni, B. Brzozowska, P. J. Bussey, B. Bylsma, A. Caldwell, M. Capua, R. Carlin, C. D. Catterall, S. Chekanov, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, A. M. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, G. D’Agostini, F. Dal Corso, J. Peso, R. K. Dementiev, S. Pasquale, M. Derrick, R. C. E. Devenish, D. Dobur, B. A. Dolgoshein, G. Dolinska, A. T. Doyle, V. Drugakov, L. S. Durkin, S. Dusini, Y. Eisenberg, P. F. Ermolov, A. Eskrey, S. Fang, S. Fazio, J. Ferrando, M. I. Ferrero, J. Figiel, B. Foster, G. Gach, A. Gala, E. Gallo, A. Garfagnini, A. Geiser, I. Giala, A. Gizhko, L. K. Gladilin, D. Gladkov, C. Glasman, O. Gogota, Yu. A. Golubkov, P. Göttlicher, I. Grabowska-Bold, J. Grebenyuk, I. Gregor, G. Grigorescu, G. Grzelak, O. Gueta, M. Guzik, C. Gwenlan, T. Haa, W. Hain, R. Hamatsu, J. C. Hart, H. Hartmann, G. Hartner, E. Hilger, D. Hochman, R. Hori, A. Hüttmann, Z. A. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, A. Iudin, H.-P. Jakob, F. Januschek, T. W. Jone, M. Jüngst, I. Kadenko, B. Kahle, S. Kananov, T. Kanno, U. Karshon, F. Karsten, I. I. Katkov, M. Kaur, P. Kaur, A. Keramida, L. A. Khein, J. Y. Kim, D. Kisielewska, S. Kitamura, R. Klanner, U. Klein, E. Koffeman, N. Kondrashova, O. Kononenko, P. Kooijman, Ie. Korol, I. A. Korzhavina, A. Kotanski, U. Kötz, N. Kovalchuk, H. Kowalski, O. Kuprash, M. Kuze, A. Lee, B. B. Levchenko, A. Levy, V. Libov, S. Limentani, T. Y. Ling, M. Lisovyi, E. Lobodzinska, W. Lohmann, B. Löhr, E. Lohrmann, K. R. Long, A. Longhin, D. Lontkovskyi, O. Yu. Lukina, J. Maeda, S. Magill, I. Makarenko, J. Malka, R. Mankel, A. Margotti, G. Marini, J. F. Martin, A. Mastroberardino, M. C. K. Mattingly, I.-A. Melzer-Pellmann, S. Mergelmeyer, S. Miglioranzi, F. Mohamad Idri, V. Monaco, A. Montanari, J. D. Morri, K. Mujkic, B. Musgrave, K. Nagano, T. Namsoo, R. Nania, A. Nigro, Y. Ning, T. Nobe, D. Notz, R. J. Nowak, A. E. Nuncio-Quiroz, B. Y. Oh, N. Okazaki, K. Olkiewicz, Yu. Onishchuk, K. Papageorgiu, A. Parenti, E. Paul, J. M. Pawlak, B. Pawlik, P. G. Pelfer, A. Pellegrino, W. Perlanski, H. Perrey, K. Piotrzkowski, P. Plucinski, N. S. Pokrovskiy, A. Polini, A. S. Proskuryakov, M. Przybycien, A. Raval, D. D. Reeder, B. Reisert, Z. Ren, J. Repond, Y. D. Ri, A. Robertson, P. Roloff, I. Rubinsky, M. Ruspa, R. Sacchi, U. Samson, G. Sartorelli, A. A. Savin, D. H. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W. B. Schmidke, U. Schneekloth, V. Schönberg, T. Schörner-Sadeniu, J. Schwartz, F. Sciulli, L. M. Shcheglova, R. Shehzadi, S. Shimizu, I. Singh, I. O. Skillicorn, W. Slominski, W. H. Smith, V. Sola, A. Solano, D. Son, V. Sosnovtsev, A. Spiridonov, H. Stadie, L. Stanco, N. Stefaniuk, A. Stern, T. P. Stewart, A. Stifutkin, P. Stopa, S. Suchkov, G. Susinno, L. Suszycki, J. Sztuk-Dambietz, D. Szuba, J. Szuba, A. D. Tapper, E. Tassi, J. Terrón, T. Theedt, H. Tiecke, K. Tokushuku, J. Tomaszewska, A. Trofymov, V. Trusov, T. Tsurugai, M. Turcato, O. Turkot, T. Tymieniecka, M. Vázquez, A. Verbytskyi, O. Viazlo, N. N. Vlasov, R. Walczak, W. A. T. Wan Abdullah, J. J. Whitmore, K. Wichmann, L. Wigger, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, A. G. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, N. Zakharchuk, A. F. Żarnecki, L. Zawiejski, O. Zenaiev, W. Zeuner, B. O. Zhautykov, N. Zhmak, A. Zichichi, Z. Zolkapli, and D. S. Zotkin

Subjects
Particle physics, Nuclear and High Energy Physics, Meson, Lepton-Nucleon Scattering, Nuclear Theory, HERA, FOS: Physical sciences, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), High Energy Physics, ZEUS Collaboration, 0103 physical sciences, ddc:530, Charm (quantum number), 010306 general physics, Nuclear Experiment, charm physics, Charm physics, Quantum chromodynamics, Physics, Luminosity (scattering theory), ZEUS (particle detector), 010308 nuclear & particles physics, Scattering, High Energy Physics::Phenomenology, Física, lepton-nucleon scattering, Deep inelastic scattering, High Energy Physics::Experiment, Particle Physics - Experiment
Abstract

The production of $D^{*\pm}$ mesons in deep inelastic $ep$ scattering has been measured for exchanged photon virtualities $ 5, Comment: new version with errors fixed in tables 7,9,10 and figures 9,10

Published
2013

38. Measurement of D ± production in deep inelastic ep scattering with the ZEUS detector at HERA

Author

F. Mohamad Idris, D.D. Reeder, J. Ciborowski, Tobias M. Haas, Ramoona Shehzadi, B. Löhr, Krzysztof Piotrzkowski, K. Wrona, Manjit Kaur, Shoichi Yamada, R.C.E. Devenish, T. Schörner-Sadenius, V. Schönberg, B. Foster, Alexander Spiridonov, S. Dusini, O. Zenaiev, I. A. Melzer-Pellmann, P. Göttlicher, V. Sosnovtsev, Ewelina Lobodzinska, J. Y. Kim, A.G. Robertson, Mariusz Przybycien, M. Corradi, O. Viazlo, R. Yoshida, Fernando Barreiro, A. Eskreys, A. Polini, M. Kuze, E. Lohrmann, M. Ishitsuka, Valentina Sola, L. Suszycki, Marco Schioppa, Pietro Antonioli, U. Schneekloth, Denys Lontkovskyi, Zhongliang Ren, L. K. Gladilin, R. K. Dementiev, Grzegorz Gach, W. Slominski, A. Longhin, Claudia Glasman, V. Drugakov, P. G. Pelfer, S.I. Suchkov, Janna Katharina Behr, F. Dal Corso, A. Bruni, I. Gialas, Nazar Bartosik, S. Kitamura, S. Fazio, Roberto Sacchi, J. M. Pawlak, Lev Khein, M. Basile, J. Sztuk-Dambietz, Didar Dobur, Enrico Tassi, J. J. Whitmore, L. Cifarelli, N. Kondrashova, S. Kananov, M. Vázquez, J. Szuba, Kenneth Long, Aharon Levy, K. Mujkic, A. Garfagnini, Francois Corriveau, A. M. Cooper-Sarkar, Takuya Nobe, D. Hochman, H.G.J.M. Tiecke, A. Kotański, I. Kadenko, M. Derrick, Y. Aushev, G. Bari, A. Nigro, Shinichi Shimizu, Hanno Perrey, Yu. A. Golubkov, E. Paul, Leszek Adamczyk, M. Wlasenko, Af Zarnecki, U. Samson, Elisabetta Gallo, Yu. Onishchuk, J. Maeda, Giovanna Bruni, B. Kahle, W. H. Smith, R. Hori, S. Schlenstedt, Mário Costa, Y. Ning, P. J. Bussey, F. J. Sciulli, Roberto Carlin, Marcin Pawel Guzik, R. Aggarwal, Ganna Dolinska, Alexander Tapper, Ozan Arslan, Rosario Nania, Vladyslav Libov, S. Fang, Sebastian Mergelmeyer, S. Miglioranzi, A. Raval, Danuta Kisielewska, T. P. Stewart, C. Youngman, Pawel Plucinski, Andrii Gizhko, U. Karshon, N. Zhmak, T. Kanno, Alexander Savin, M.I. Ferrero, F. Karstens, Yuji Yamazaki, A. Keramidas, D. Boscherini, Katsuo Tokushuku, Igor Katkov, G. Susinno, Ian Brock, A. Bertolin, J. Schwartz, J. Tomaszewska, O. Turkot, Ada Solano, V. Bokhonov, G. Grzelak, T. Theedt, S. Limentani, N. Zakharchuk, Philipp Roloff, L. Zawiejski, Janusz Chwastowski, Hartmut Stadie, M. Turcato, Claire Gwenlan, F. Januschek, Giuseppe Barbagli, I. Makarenko, A. Hüttmann, Matthew Wing, Kunihiro Nagano, I. Singh, D. H. Saxon, I. Abt, A. Galas, J. Malka, S. Magill, Anna Mastroberardino, Andrea Contin, Uta Klein, P. Kaur, S. Bhadra, I. O. Skillicorn, A. E. Nuncio-Quiroz, W. A. T. Wan Abdullah, A. Trofymov, V. Monaco, A. Stifutkin, T. Namsoo, Ie. Korol, B.O. Zhautykov, D. Bot, W. Hain, John Hart, Oleg Kuprash, I. Rubinsky, Marcella Capua, Sergei Chekanov, Dirk-Uwe Bartsch, K. Olkiewicz, Michele Arneodo, Y. Iga, A. Lee, L. Bellagamba, H. Wolfe, B. B. Levchenko, N.N. Vlasov, W. Perlanski, J. F. Martin, E. Brownson, I. A. Korzhavina, A. T. Doyle, N. Okazaki, D. Gladkov, G. D'Agostini, John Morris, Guenter Wolf, B. Brzozowska, T. Y. Ling, Iwona Grabowska-Bold, O. Gogota, A. Antonov, B. A. Dolgoshein, Orel Gueta, Andrii Verbytskyi, Marta Ruspa, H.-P. Jakob, R. Brugnera, Kerstin Borras, Dong-Chul Son, P. Stopa, O. Kononenko, Robert Klanner, C. Blohm, Jan Figiel, Y. Eisenberg, R. Walczak, A. Iudin, L. M. Shcheglova, G. Grigorescu, M. Lisovyi, Anselmo Margotti, J. Grebenyuk, L.W. Wiggers, Y. D. Ri, G. Sartorelli, L. Stanco, R. Ingbir, Nazar Stefaniuk, Ulf Behrens, Federico Cindolo, H. Kowalski, V. Trusov, N. Brümmer, T. Tsurugai, R. Mankel, Wolfgang Lohmann, O. Yu. Lukina, B. Reisert, Alessandro Montanari, N. Kovalchuk, N. Coppola, A.G. Yagües-Molina, J. Del Peso, W. B. Schmidke, E. Hilger, E.G. Boos, K. Papageorgiu, B.Y. Oh, Marcello Bindi, B. Pawlik, S. De Pasquale, A. N. Barakbaev, N.S. Pokrovskiy, Zukhaimira Zolkapli, Allen Caldwell, A. Stern, Zainol Abidin Ibrahim, T. Tymieniecka, J. Repond, A. Parenti, U. Kötz, R. J. Nowak, A. Pellegrino, M.C.K. Mattingly, L. S. Durkin, R. Hamatsu, O. Bachynska, Els Koffeman, Peter Schleper, V. Aushev, K. Wichmann, M. Adamus, G. Marini, Wolfram Dietrich Zeuner, A. Bamberger, A. Zichichi, D. Notz, D.S. Zotkin, C. D. Catterall, T. W. Jones, M. Jüngst, Ben Bylsma, D. Szuba, G. Hartner, I. M. Gregor, H. Hartmann, Halina Abramowicz, P.F. Ermolov, James Ferrando, P.M. Kooijman, Achim Geiser, Juan Terron, B. Musgrave, S. Antonelli, Tomasz Bold, Robert Ciesielski, O. Behnke, A.S. Proskuryakov, Zeus (IHEF, IoP, FNWI), H. Abramowicz, I. Abt, L. Adamczyk, M. Adamu, R. Aggarwal, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, O. Arslan, V. Aushev, Y. Aushev, O. Bachynska, A. Bamberger, A. N. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, N. Bartosik, D. Bartsch, M. Basile, O. Behnke, J. Behr, U. Behren, L. Bellagamba, A. Bertolin, S. Bhadra, M. Bindi, C. Blohm, V. Bokhonov, T. Bold, E. G. Boo, K. Borra, D. Boscherini, D. Bot, I. Brock, E. Brownson, R. Brugnera, N. Brümmer, A. Bruni, G. Bruni, B. Brzozowska, P. J. Bussey, B. Bylsma, A. Caldwell, M. Capua, R. Carlin, C. D. Catterall, S. Chekanov, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, A. M. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, G. D’Agostini, F. Dal Corso, J. Peso, R. K. Dementiev, S. Pasquale, M. Derrick, R. C. E. Devenish, D. Dobur, B. A. Dolgoshein, G. Dolinska, A. T. Doyle, V. Drugakov, L. S. Durkin, S. Dusini, Y. Eisenberg, P. F. Ermolov, A. Eskrey, S. Fang, S. Fazio, J. Ferrando, M. I. Ferrero, J. Figiel, B. Foster, G. Gach, A. Gala, E. Gallo, A. Garfagnini, A. Geiser, I. Giala, A. Gizhko, L. K. Gladilin, D. Gladkov, C. Glasman, O. Gogota, Yu. A. Golubkov, P. Göttlicher, I. Grabowska-Bold, J. Grebenyuk, I. Gregor, G. Grigorescu, G. Grzelak, O. Gueta, M. Guzik, C. Gwenlan, T. Haa, W. Hain, R. Hamatsu, J. C. Hart, H. Hartmann, G. Hartner, E. Hilger, D. Hochman, R. Hori, A. Hüttmann, Z. A. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, A. Iudin, H.-P. Jakob, F. Januschek, T. W. Jone, M. Jüngst, I. Kadenko, B. Kahle, S. Kananov, T. Kanno, U. Karshon, F. Karsten, I. I. Katkov, M. Kaur, P. Kaur, A. Keramida, L. A. Khein, J. Y. Kim, D. Kisielewska, S. Kitamura, R. Klanner, U. Klein, E. Koffeman, N. Kondrashova, O. Kononenko, P. Kooijman, Ie. Korol, I. A. Korzhavina, A. Kotanski, U. Kötz, N. Kovalchuk, H. Kowalski, O. Kuprash, M. Kuze, A. Lee, B. B. Levchenko, A. Levy, V. Libov, S. Limentani, T. Y. Ling, M. Lisovyi, E. Lobodzinska, W. Lohmann, B. Löhr, E. Lohrmann, K. R. Long, A. Longhin, D. Lontkovskyi, O. Yu. Lukina, J. Maeda, S. Magill, I. Makarenko, J. Malka, R. Mankel, A. Margotti, G. Marini, J. F. Martin, A. Mastroberardino, M. C. K. Mattingly, I.-A. Melzer-Pellmann, S. Mergelmeyer, S. Miglioranzi, F. Mohamad Idri, V. Monaco, A. Montanari, J. D. Morri, K. Mujkic, B. Musgrave, K. Nagano, T. Namsoo, R. Nania, A. Nigro, Y. Ning, T. Nobe, D. Notz, R. J. Nowak, A. E. Nuncio-Quiroz, B. Y. Oh, N. Okazaki, K. Olkiewicz, Yu. Onishchuk, K. Papageorgiu, A. Parenti, E. Paul, J. M. Pawlak, B. Pawlik, P. G. Pelfer, A. Pellegrino, W. Perlanski, H. Perrey, K. Piotrzkowski, P. Plucinski, N. S. Pokrovskiy, A. Polini, A. S. Proskuryakov, M. Przybycien, A. Raval, D. D. Reeder, B. Reisert, Z. Ren, J. Repond, Y. D. Ri, A. Robertson, P. Roloff, I. Rubinsky, M. Ruspa, R. Sacchi, U. Samson, G. Sartorelli, A. A. Savin, D. H. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W. B. Schmidke, U. Schneekloth, V. Schönberg, T. Schörner-Sadeniu, J. Schwartz, F. Sciulli, L. M. Shcheglova, R. Shehzadi, S. Shimizu, I. Singh, I. O. Skillicorn, W. Slominski, W. H. Smith, V. Sola, A. Solano, D. Son, V. Sosnovtsev, A. Spiridonov, H. Stadie, L. Stanco, N. Stefaniuk, A. Stern, T. P. Stewart, A. Stifutkin, P. Stopa, S. Suchkov, G. Susinno, L. Suszycki, J. Sztuk-Dambietz, D. Szuba, J. Szuba, A. D. Tapper, E. Tassi, J. Terrón, T. Theedt, H. Tiecke, K. Tokushuku, J. Tomaszewska, A. Trofymov, V. Trusov, T. Tsurugai, M. Turcato, O. Turkot, T. Tymieniecka, M. Vázquez, A. Verbytskyi, O. Viazlo, N. N. Vlasov, R. Walczak, W. A. T. Wan Abdullah, J. J. Whitmore, K. Wichmann, L. Wigger, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, A. G. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, N. Zakharchuk, A. F. Żarnecki, L. Zawiejski, O. Zenaiev, W. Zeuner, B. O. Zhautykov, N. Zhmak, A. Zichichi, Z. Zolkapli, and D. S. Zotkin

Subjects
Nuclear and High Energy Physics, Particle physics, Photon, Meson, Lepton-Nucleon Scattering, HERA, 01 natural sciences, Charm quark, Nuclear physics, High Energy Physics, ZEUS Collaboration, 0103 physical sciences, ddc:530, 010306 general physics, Nuclear Experiment, Physics, Quantum chromodynamics, 010308 nuclear & particles physics, Scattering, heavy quark production, lepton-nucleon scattering, High Energy Physics::Phenomenology, Strangeness production, Pseudorapidity, High Energy Physics::Experiment
Abstract

Charm production in deep inelastic ep scattering was measured with the ZEUS detector using an integrated luminosity of 354 pb−1. Charm quarks were identified by reconstructing D ± mesons in the D ± → K ∓π±π± decay channel. Lifetime information was used to reduce combinatorial background substantially. Differential cross sections were measured in the kinematic region 5 < Q 2 < 1000 GeV2, 0.02 < y < 0.7, 1.5 < p T (D ±) < 15 GeV and |η(D ±)| < 1.6, where Q 2 is the photon virtuality, y is the inelasticity, and p T (D ±) and η(D ±) are the transverse momentum and the pseudorapidity of the D ± meson, respectively. Next-to-leading-order QCD predictions are compared to the data. The charm contribution, $ F_2^{{c\overline{c}}} $ , to the proton structure-function F 2 was extracted.

Published
2013

39. Combination and QCD analysis of charm production cross section measurements in deep-inelastic ep scattering at HERA

Author

Olaf Behnke, E. Brownson, H. Perrey, T. Tsurugai, C. Niebuhr, K. H. Hiller, R. C. W. Henderson, Alexander Spiridonov, I. A. Melzer-Pellmann, C. Pascaud, N. Coppola, F. Huber, Wolfgang Lohmann, Z. Ren, Grzegorz Nowak, A. Dossanov, B. Musgrave, A. Galas, P. Truoel, D. Haidt, Roland Horisberger, Michele Arneodo, A. Valkárová, E. Elsen, Hans-Christian Schultz-Coulon, Andrea Contin, A. Lebedev, W. Perlanski, G. F. Susinno, N. Okazaki, John Morris, Fabian Zomer, Kenneth Long, A. Longhin, K. Lipka, Takuya Nobe, M. Pandurovic, B. B. Levchenko, Karel Cerny, A. Huettmann, Anna Mastroberardino, I. Picuric, M. Juengst, G. Bari, A. Specka, S. Schlenstedt, Amanda Cooper-Sarkar, Valentina Sola, Alexander Bylinkin, J. Maeda, H.-P. Jakob, Giovanna Bruni, J. Cvach, L. M. Shcheglova, S. Egli, A. Nigro, D. Wegener, R. Brugnera, L. Suszycki, Guenter Eckerlin, L. Goerlich, P. Stopa, S. Shushkevich, Marcella Capua, A. Bruni, Paul Laycock, E. Malinovski, Emmanuel Sauvan, H. U. Martyn, F. Dal Corso, Matthias Klein, Tomas Hreus, Kerstin Borras, Roman Kogler, A. Petrukhin, P. Kostka, Dong-Chul Son, E. Wuensch, M. Wlasenko, Z. Zolkapli, V. Brisson, Ozan Arslan, B. Pokorny, Af Zarnecki, J. Turnau, Eram Rizvi, K. Begzsuren, S. Yamada, E. Hilger, Hannes Jung, Gerhard Brandt, I. Tsakov, A. Gizhko, O. Kononenko, J. Behr, T. H. Tran, R.C.E. Devenish, O. Zenaiev, L. Stanco, R. Zlebcik, R. Ingbir, P.F. Ermolov, A.S. Proskuryakov, Anselmo Margotti, G. Grindhammer, B. Brzozowska, E.G. Boos, J. Tomaszewska, J. Zacek, Katsuo Tokushuku, V.V. Sosnovtsev, J. Del Peso, Marcello Bindi, B. Pawlik, Xavier Janssen, C. Blohm, M. C. K. Mattingly, B. Stella, Marco Schioppa, P. G. Pelfer, Rosario Nania, S. Habib, A. N. Barakbaev, Benno List, P. D. Thompson, M. Fleischer, M. Dobre, Nazar Bartosik, V. Dodonov, Enrico Tassi, J. J. Whitmore, M. Kuze, J. Grebenyuk, L.W. Wiggers, D. Gladkov, M. Kapichine, K. Mujkic, M. Kraemer, Richard Polifka, U. Karshon, O. Zabiegalov, F. Moreau, Voica Radescu, E. Lohrmann, T. P. Stewart, D. Boscherini, Janusz Chwastowski, A. Kotański, M. Jacquet, Pawel Plucinski, A. Raval, J. Ciborowski, K. Daum, James Ferrando, I. Gregor, Nazar Stefaniuk, Yuji Yamazaki, Christoph Grab, Grzegorz Gach, Zhen Zhang, J. E. Ruiz Tabasco, E. A. De Wolf, R. Roosen, Fernando Barreiro, S.I. Suchkov, A. Verbytskyi, Ricardo Lopez-Fernandez, J. Szuba, A. Glazov, M. Brinkmann, S. Bhadra, Iwona Grabowska-Bold, B. Y. Oh, Emmanuelle Perez, Tomas Sykora, M. Sauter, R. Hori, I. Bozovic-Jelisavcic, M. Basile, Manjit Kaur, J. Malka, Roman Walczak, Y. Vazdik, F. J. Sciulli, Alexander Tapper, V. Lubimov, W. Słomiński, A. Antonov, Ulf Behrens, Federico Cindolo, H. Kowalski, H. J. Meyer, S. Magill, S. Levonian, T. Haas, B. Lobodzinski, Didar Dobur, Thomas Schoerner-Sadenius, J. Schwartz, A. Lee, M. Steder, Stephen Maxfield, S. De Pasquale, A. Polini, D. Lontkovskyi, Ie. Korol, Giuseppe Barbagli, V. Trusov, N.S. Pokrovskiy, Daniel Pitzl, Andreas Meyer, A. G. Yaguees-Molina, D. Szuba, I. Makarenko, Y. Iga, D. Hoffmann, Vladimir Palichik, C. Youngman, Andrew Mehta, U. Klein, O. Turkot, Y.D. Ri, Leif J. Jönsson, Y. Aushev, G. Hartner, N. Gogitidze, H. Hartmann, K. Nowak, Hartmut Stadie, T. Namsoo, Bogdan Povh, F. Sefkow, Z. Staykova, J. E. Olsson, S. Mikocki, Y. Eisenberg, I. O. Skillicorn, H. Henschel, Ada Solano, V. Bokhonov, S. Limentani, Allen Caldwell, Federico Alberto Ceccopieri, A. V. Fedotov, Zainol Abidin Ibrahim, David M. South, U. Koetz, Ramoona Shehzadi, A. Keramidas, I. A. Korzhavina, A. Baghdasaryan, Danuta Kisielewska, S. Schmitt, Adrian Stern, Claudia Glasman, A. Bertolin, A. Rostovtsev, T. Tymieniecka, V. Drugakov, Malte Hildebrandt, Shima Shimizu, R. Yoshida, Marcin Pawel Guzik, A. W. Jung, K. Mueller, I. I. Katkov, U. Schneekloth, Jan Kretzschmar, J. Zálešák, O. Gogota, R. Ciesielski, Elisabetta Gallo, Yu. Onishchuk, Halina Abramowicz, Laurent Schoeffel, R. Aggarwal, J. F. Martin, V. Spaskov, Y. Ning, Yu. A. Golubkov, E. Paul, G. Herrera, Tomasz Bold, Lev Khein, I. Singh, M. Turcato, J. Gayler, Murrough Landon, A. M. Fomenko, A. Zichichi, G. Grzelak, Jenny List, J. M. Pawlak, I. R. Kenyon, Kunihiro Nagano, K. B. Cantun Avila, V. Schoenberg, H.G.J.M. Tiecke, A. Parenti, D. Notz, D. J. Fischer, S. Kananov, Andre Schoening, I. Kadenko, Natasa Raicevic, B. Reisert, B. Tseepeldorj, D.S. Zotkin, T. W. Jones, C. D. Catterall, C. Kiesling, J. C. Hart, O. Kuprash, Jan Figiel, A. Garfagnini, L. Bystritskaya, G. Sartorelli, Vincent Boudry, P. Kaur, T. Greenshaw, R. J. Nowak, A. Bunyatyan, A. N. Morozov, S. Fang, Sebastian Mergelmeyer, G. Grigorescu, M. Lisovyi, Paul Newman, P.M. Kooijman, U. Samson, P. Van Mechelen, V. Libov, A. Stifutkin, R. Placakyte, H. Zohrabyan, J. Ferencei, A. Pellegrino, N. Zhmak, Peter Bussey, J. Sztuk-Dambietz, D. Salek, Gy. Wolf, T. Kanno, Achim Geiser, T. Ravdandorj, Claus Kleinwort, Alexander Savin, C. Diaconu, A. E. Nuncio-Quiroz, Claire Gwenlan, Marina Rotaru, D. Ozerov, H. Wolfe, L. S. Durkin, R. Hamatsu, W. A. T. Wan Abdullah, Ben Bylsma, Juan Terron, A. T. Doyle, V. Chekelian, P. Pahl, F. Januschek, T. Theedt, M. Derrick, O. Bachynska, Els Koffeman, E. Gabathuler, J. G. Contreras, B. A. Dolgoshein, W. B. Schmidke, U. Straumann, Orel Gueta, Marta Ruspa, S. Kitamura, G. D'Agostini, S. Ghazaryan, Thomas Naumann, V. Lendermann, D. D. Reeder, B. Kahle, S. Antonelli, Kyrylo Bondarenko, T. Y. Ling, Roberto Carlin, Ian Brock, Pavel A. Belov, Robert Klanner, G. Dolinska, Gabriel Stoicea, Peter Schleper, V. Aushev, M. Gouzevitch, E. Hennekemper, K. Papageorgiu, K. Wichmann, M. Adamus, G. Marini, Laurent Favart, F. Mohamad Idris, D. H. Saxon, Wolfram Dietrich Zeuner, A. Bamberger, A.S. Belousov, Sergey Rusakov, S. Fazio, Roberto Sacchi, Aharon Levy, W. Bartel, Dave Sankey, Rainer Mankel, N.N. Vlasov, Leszek Adamczyk, J. Delvax, N. Kondrashova, V. Andreev, M.I. Ferrero, G. D. Patel, Masaki Ishitsuka, B. Loehr, P. Goettlicher, D. Britzger, S. Miglioranzi, F. Karstens, P. E. Reimer, K. Wrona, B. Foster, Alan Campbell, S. Dusini, N. Bruemmer, J. Y. Kim, Y. Soloviev, C. Vallee, Pietro Antonioli, L. K. Gladilin, R. K. Dementiev, Krzysztof Piotrzkowski, K. Krueger, M. Herbst, I. Gialas, L. Cifarelli, E. Lobodzinska, A. Grebenyuk, Mário Costa, Wolfgang Lange, I. Abt, H. Pirumov, V. Monaco, W. Hain, A. Eskreys, S. Baghdasaryan, Jan Hladky, M. Vázquez, Peter Robmann, F. Corriveau, Olga Lukina, Juraj Bracinik, Matthew Wing, J. Repond, J. B. Dainton, P. Roloff, W. H. Smith, Sergei Chekanov, Dirk-Uwe Bartsch, I. Milcewicz-Mika, J. V. Morris, L. Bellagamba, J. Feltesse, A.G. Robertson, Mariusz Przybycien, M. Corradi, O. Viazlo, Calin Alexa, D. Traynor, D. Hochman, P. Sopicki, B.O. Zhautykov, I. Rubinsky, R. Felst, D.K. Nikitin, A. Montanari, D. Bot, G. Laštovička-Medin, K. Olkiewicz, J-P. Meyer, Zeus (IHEF, IoP, FNWI), ZEUS Collaboration (ukupan broj autora: 486), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), H1, ZEUS, H1 Collaboration, ZEUS Collaboration, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), H. Abramowicz, I. Abt, L. Adamczyk, M. Adamu, R. Aggarwal, C. Alexa, V. Andreev, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, O. Arslan, V. Aushev, Y. Aushev, O. Bachynska, A. Baghdasaryan, S. Baghdasaryan, A. Bamberger, A. N. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, W. Bartel, N. Bartosik, D. Bartsch, M. Basile, K. Begzsuren, O. Behnke, J. Behr, U. Behren, L. Bellagamba, A. Belousov, P. Belov, A. Bertolin, S. Bhadra, M. Bindi, C. Blohm, V. Bokhonov, K. Bondarenko, E. G. Boo, K. Borra, D. Boscherini, D. Bot, V. Boudry, I. Bozovic-Jelisavcic, T. Bołd, N. Brümmer, J. Bracinik, G. Brandt, M. Brinkmann, V. Brisson, D. Britzger, I. Brock, E. Brownson, R. Brugnera, A. Bruni, G. Bruni, B. Brzozowska, A. Bunyatyan, P. J. Bussey, A. Bylinkin, B. Bylsma, L. Bystritskaya, A. Caldwell, A. J. Campbell, K. B. Cantun Avila, M. Capua, R. Carlin, C. D. Catterall, F. Ceccopieri, K. Cerny, S. Chekanov, V. Chekelian, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, J. G. Contrera, A. M. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, J. Cvach, G. D’Agostini, J. B. Dainton, F. Dal Corso, K. Daum, J. Delvax, R. K. Dementiev, M. Derrick, R. C. E. Devenish, S. Pasquale, E. A. Wolf, J. Peso, C. Diaconu, M. Dobre, D. Dobur, V. Dodonov, B. A. Dolgoshein, G. Dolinska, A. Dossanov, A. T. Doyle, V. Drugakov, L. S. Durkin, S. Dusini, G. Eckerlin, S. Egli, Y. Eisenberg, E. Elsen, P. F. Ermolov, A. Eskrey, S. Fang, L. Favart, S. Fazio, A. Fedotov, R. Felst, J. Feltesse, J. Ferencei, J. Ferrando, M. I. Ferrero, J. Figiel, D.-J. Fischer, M. Fleischer, A. Fomenko, B. Foster, E. Gabathuler, G. Gach, A. Gala, E. Gallo, A. Garfagnini, J. Gayler, A. Geiser, S. Ghazaryan, I. Giala, A. Gizhko, L. K. Gladilin, D. Gladkov, C. Glasman, A. Glazov, L. Goerlich, N. Gogitidze, O. Gogota, Y. A. Golubkov, P. Göttlicher, M. Gouzevitch, C. Grab, I. Grabowska-Bołd, A. Grebenyuk, J. Grebenyuk, T. Greenshaw, I. Gregor, G. Grigorescu, G. Grindhammer, G. Grzelak, O. Gueta, M. Guzik, C. Gwenlan, A. Hüttmann, T. Haa, S. Habib, D. Haidt, W. Hain, R. Hamatsu, J. C. Hart, H. Hartmann, G. Hartner, R. C. W. Henderson, E. Hennekemper, H. Henschel, M. Herbst, G. Herrera, M. Hildebrandt, E. Hilger, K. H. Hiller, J. Hladký, D. Hochman, D. Hoffmann, R. Hori, R. Horisberger, T. Hreu, F. Huber, Z. A. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, M. Jacquet, H.-P. Jakob, X. Janssen, F. Januschek, T. W. Jone, L. Jönsson, M. Jüngst, A. W. Jung, H. Jung, I. Kadenko, B. Kahle, S. Kananov, T. Kanno, M. Kapichine, U. Karshon, F. Karsten, I. I. Katkov, P. Kaur, M. Kaur, I. R. Kenyon, A. Keramida, L. A. Khein, C. Kiesling, J. Y. Kim, D. Kisielewska, S. Kitamura, R. Klanner, M. Klein, U. Klein, C. Kleinwort, U. Kötz, E. Koffeman, R. Kogler, N. Kondrashova, O. Kononenko, P. Kooijman, I. Korol, I. A. Korzhavina, P. Kostka, A. Kotański, H. Kowalski, M. Krämer, J. Kretzschmar, K. Krüger, O. Kuprash, M. Kuze, M. P. J. Landon, W. Lange, G. Laštovička-Medin, P. Laycock, A. Lebedev, A. Lee, V. Lendermann, B. B. Levchenko, S. Levonian, A. Levy, V. Libov, S. Limentani, T. Y. Ling, K. Lipka, M. Lisovyi, B. List, J. List, E. Lobodzinska, B. Lobodzinski, B. Löhr, W. Lohmann, E. Lohrmann, K. R. Long, A. Longhin, D. Lontkovskyi, R. Lopez-Fernandez, V. Lubimov, O. Y. Lukina, J. Maeda, S. Magill, I. Makarenko, E. Malinovski, J. Malka, R. Mankel, A. Margotti, G. Marini, J. F. Martin, H.-U. Martyn, A. Mastroberardino, M. C. K. Mattingly, S. J. Maxfield, A. Mehta, I.-A. Melzer-Pellmann, S. Mergelmeyer, A. B. Meyer, H. Meyer, J. Meyer, S. Miglioranzi, S. Mikocki, I. Milcewicz-Mika, F. Mohamad Idri, V. Monaco, A. Montanari, F. Moreau, A. Morozov, J. V. Morri, J. D. Morri, K. Mujkic, K. Müller, B. Musgrave, K. Nagano, T. Namsoo, R. Nania, T. Naumann, P. R. Newman, C. Niebuhr, A. Nigro, D. Nikitin, Y. Ning, T. Nobe, D. Notz, G. Nowak, K. Nowak, R. J. Nowak, A. E. Nuncio-Quiroz, B. Y. Oh, N. Okazaki, K. Olkiewicz, J. E. Olsson, Y. Onishchuk, D. Ozerov, P. Pahl, V. Palichik, M. Pandurovic, K. Papageorgiu, A. Parenti, C. Pascaud, G. D. Patel, E. Paul, J. M. Pawlak, B. Pawlik, P. G. Pelfer, A. Pellegrino, E. Perez, W. Perlański, H. Perrey, A. Petrukhin, I. Picuric, K. Piotrzkowski, H. Pirumov, D. Pitzl, R. Plačakytė, P. Pluciński, B. Pokorny, N. S. Pokrovskiy, R. Polifka, A. Polini, B. Povh, A. S. Proskuryakov, M. Przybycień, V. Radescu, N. Raicevic, A. Raval, T. Ravdandorj, D. D. Reeder, P. Reimer, B. Reisert, Z. Ren, J. Repond, Y. D. Ri, E. Rizvi, A. Robertson, P. Robmann, P. Roloff, R. Roosen, A. Rostovtsev, M. Rotaru, I. Rubinsky, J. E. Ruiz Tabasco, S. Rusakov, M. Ruspa, R. Sacchi, D. Šálek, U. Samson, D. P. C. Sankey, G. Sartorelli, M. Sauter, E. Sauvan, A. A. Savin, D. H. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W. B. Schmidke, S. Schmitt, U. Schneekloth, L. Schoeffel, V. Schönberg, A. Schöning, T. Schörner-Sadeniu, H.-C. Schultz-Coulon, J. Schwartz, F. Sciulli, F. Sefkow, L. M. Shcheglova, R. Shehzadi, S. Shimizu, S. Shushkevich, I. Singh, I. O. Skillicorn, W. Słomiński, W. H. Smith, V. Sola, A. Solano, Y. Soloviev, D. Son, P. Sopicki, V. Sosnovtsev, D. South, V. Spaskov, A. Specka, A. Spiridonov, H. Stadie, L. Stanco, Z. Staykova, M. Steder, N. Stefaniuk, B. Stella, A. Stern, T. P. Stewart, A. Stifutkin, G. Stoicea, P. Stopa, U. Straumann, S. Suchkov, G. Susinno, L. Suszycki, T. Sykora, J. Sztuk-Dambietz, J. Szuba, D. Szuba, A. D. Tapper, E. Tassi, J. Terrón, T. Theedt, P. D. Thompson, H. Tiecke, K. Tokushuku, J. Tomaszewska, T. H. Tran, D. Traynor, P. Truöl, V. Trusov, I. Tsakov, B. Tseepeldorj, T. Tsurugai, M. Turcato, O. Turkot, J. Turnau, T. Tymieniecka, M. Vázquez, A. Valkárová, C. Vallée, P. Mechelen, Y. Vazdik, A. Verbytskyi, O. Viazlo, N. N. Vlasov, R. Walczak, W. A. T. Wan Abdullah, D. Wegener, J. J. Whitmore, K. Wichmann, L. Wigger, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, E. Wünsch, A. G. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, O. Zabiegalov, J. Žáček, J. Zálešák, O. Zenaiev, W. Zeuner, Z. Zhang, B. O. Zhautykov, N. Zhmak, A. Zichichi, R. Žlebčík, H. Zohrabyan, Z. Zolkapli, F. Zomer, D. S. Zotkin, and A. F. Żarnecki

Subjects
Quark, Particle physics, Physics and Astronomy (miscellaneous), Lepton-Nucleon Scattering, HERA, FOS: Physical sciences, Parton, Inelastic scattering, 01 natural sciences, Charm quark, Systematic Uncertainty, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), Charm Quark, Charm Production, Reduce Cross Section, Charm Quark Mass, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:530, Charm (quantum number), High Energy Physics, 010306 general physics, Nuclear Experiment, Engineering (miscellaneous), H1 Collaboration, Physics, ZEUS Collaboration, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Deep inelastic scattering, Distribution function, Physique des particules élémentaires, High Energy Physics::Experiment
Abstract

Measurements of open charm production cross sections in deep-inelastic ep scattering at HERA from the H1 and ZEUS Collaborations are combined. Reduced cross sections σredcc̄ for charm production are obtained in the kinematic range of photon virtuality 2. 5≤Q2≤2000 GeV2 and Bjorken scaling variable 3{dot operator}10-5≤x≤5{dot operator}10-2. The combination method accounts for the correlations of the systematic uncertainties among the different data sets. The combined charm data together with the combined inclusive deep-inelastic scattering cross sections from HERA are used as input for a detailed NLO QCD analysis to study the influence of different heavy flavour schemes on the parton distribution functions. The optimal values of the charm mass as a parameter in these different schemes are obtained. The implications on the NLO predictions for W± and Z production cross sections at the LHC are investigated. Using the fixed flavour number scheme, the running mass of the charm quark is determined. © 2013 The Author(s)., 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2013

40. Analysis of specificity of antibodies against synthetic fragments of different neuronal nicotinic acetylcholine receptor subunits

Author

E. Yu. Lykhmus, Maryna Skok, Igor E. Kasheverov, Elena V. Kryukova, V. I. Tsetlin, D. Yu. Mordvintsev, Irina V. Shelukhina, and Maxim N. Zhmak

Subjects
animal structures, alpha7 Nicotinic Acetylcholine Receptor, Protein subunit, Molecular Sequence Data, Biophysics, Receptors, Nicotinic, Torpedo, Biochemistry, Biochemistry, Genetics and Molecular Biology (miscellaneous), Antibodies, Protein Structure, Secondary, Epitope, law.invention, Western blot, Antibody Specificity, law, Extracellular, medicine, Animals, Amino Acid Sequence, Acetylcholine receptor, Neurons, Binding Sites, biology, medicine.diagnostic_test, Chemistry, General Medicine, musculoskeletal system, Molecular biology, Peptide Fragments, Protein Structure, Tertiary, Rats, Protein Subunits, Nicotinic acetylcholine receptor, Polyclonal antibodies, Adrenal Cortex, biology.protein, Geriatrics and Gerontology
Abstract

We have compared specificity of a panel of polyclonal antibodies against synthetic fragments of the alpha7 subunit of homooligomeric acetylcholine receptor (AChR) and some subunits of heteromeric AChRs. The antibody interaction with extracellular domain of alpha7 subunit of rat AChR (residues 7-208) produced by heterologous expression in E. coli and rat adrenal membranes was investigated by the ELISA method. For comparison, membranes from the Torpedo californica ray electric organ enriched in muscle-type AChR and polyclonal antibodies raised against the extracellular domain (residues 1-209) of the T. californica AChR alpha1 subunit were also used. Antibody specificity was also characterized by Western blot analysis using rat AChR extracellular domain alpha7 (7-208) and the membrane-bound T. californica AChR. Epitope localization was analyzed within the framework of AChR extracellular domain model based on the crystal structure of acetylcholine-binding protein available in the literature. According to this analysis, the 179-190 epitope is located on loop C, which is exposed and mobile. Use of antibodies against alpha7 (179-190) revealed the presence of alpha7 AChR in rat adrenal membranes.

Published
2006

41. alpha-Conotoxin GI benzoylphenylalanine derivatives. 1H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor

Author

Igor E. Kasheverov, Yuri N. Utkin, Maxim N. Zhmak, Alexander S. Arseniev, Victor I. Tsetlin, Jonathan B. Cohen, David C. Chiara, Innokenty V. Maslennikov, and Vladimir S. Pashkov

Subjects
Models, Molecular, Protein Conformation, Stereochemistry, Phenylalanine, Photoaffinity Labels, Receptors, Nicotinic, Torpedo, Biochemistry, law.invention, Radioligand Assay, Protein structure, law, Animals, Amino Acid Sequence, Binding site, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology, G alpha subunit, Binding Sites, Edman degradation, Photoaffinity labeling, Chemistry, Cell Biology, Peptide Fragments, Nicotinic acetylcholine receptor, Cross-Linking Reagents, Conotoxins, Gamma subunit
Abstract

alpha-Conotoxins are small peptides from cone snail venoms that function as nicotinic acetylcholine receptor (nAChR)-competitive antagonists differentiating between nAChR subtypes. Current understanding about the mechanism of these selective interactions is based largely on mutational analyses, which identify amino acids in the toxin and nAChR that determine the energetics of ligand binding. To identify regions of the nAChR involved in alpha-conotoxin binding by use of photoactivated cross-linking, two benzoylphenylalanine (Bpa) analogs of alpha-conotoxin GI, GI(Bpa12) and GI(Bpa4), were synthesized by replacing the respective residues with Bpa, and their (1)H-NMR structures were determined. Both analogs preserved the GI conformation, but only GI(Bpa12) displaced (125)I-labeled GI from the Torpedo californica nAChR. (125)I-labeled GI(Bpa12) bound to two sites on the receptor (K(d) 13 and 1800 nM), and on UV irradiation specifically photolabeled the alpha, gamma and delta subunits. Photolabeling sites were mapped by selective proteolysis and enzymatic deglycosylation, combined with SDS/PAGE, HPLC and Edman degradation. In the alpha subunit, cobratoxin-inhibited incorporation was limited to the 22-kDa fragment beginning at alphaSer173 and containing the agonist-binding site segment C. In the gamma subunit, radioactivity was localized to two distinct peptides containing agonist-binding site segments F and D: nonglycosylated 24-kDa and glycosylated 13-kDa fragments starting at gammaAla167 and gammaAla49, respectively. The labeling of these fragments is discussed in terms of a model of GI(Bpa12) bound to the extracellular domain of the Torpedo nAChR homology model derived from the cryo-electron microscopy structure of Torpedo marmorata nAChR and X-ray crystal structures of snail acetylcholine-binding protein complexes with agonists and antagonists.

Published
2006

42. Production of antibodies to the α7-subunit of human acetylcholine receptor with the use of immunoactive synthetic peptides

Author

M. A. Titova, Maxim N. Zhmak, D. O. Koroev, T. D. Volkova, M. B. Oboznaya, Olga M. Volpina, T. A. Aleekseev, and V. I. Tsetlin

Subjects
Antiserum, Protein subunit, Organic Chemistry, Biology, Biochemistry, Molecular biology, Epitope, law.invention, law, Recombinant DNA, Extracellular, Receptor, Torpedo, Acetylcholine receptor
Abstract

Potential B epitopes and T-helper epitopes in the N-terminal extracellular domain of the α7-subunit of human acetylchloline receptor (AChR) were theoretically calculated in order to reveal peptides that can induce the formation of specific antibodies to this domain. Four peptides structurally corresponding to four α7-subunit regions containing 16–23 aa and three of their truncated analogues were synthesized. Rabbits were immunized with both free peptides and protein conjugates of their truncated analogues, and a panel of antibodies to various exposed regions of the N-terminal extracellular domain of the AChR α7-subunit was obtained. All of the four predicted peptides were shown to induce the production of antipeptide antibodies in free form, without conjugation with any protein carrier. The free peptides and the protein conjugates of truncated analogues induced the formation of almost equal levels of antibodies. Most of the obtained antisera contained antibodies that bind to the recombinant extracellular N-terminal domain of the rat AChR α7-subunit and do not react with the analogous domain of the α1-subunit of the ray Torpedo californica AChR.

Published
2006

43. Rational design of new ligands for nicotinic receptors on the basis of α-conotoxin PnIA

Author

Maxim N. Zhmak, Igor E. Kasheverov, Igor Ivanov, Valentin M. Tabakmakher, Elena Zelepuga, Roman G. Efremov, Anton O. Chugunov, V. I. Tsetlin, and Denis S. Kudryavtsev

Subjects
Models, Molecular, alpha7 Nicotinic Acetylcholine Receptor, Stereochemistry, Molecular Sequence Data, Biophysics, Nicotinic Antagonists, Ligands, Biochemistry, Membrane Potentials, Xenopus laevis, Aplysia, Animals, Humans, Amino Acid Sequence, Nicotinic Agonists, α conotoxin, Lymnaea, Nicotinic Receptors, Dose-Response Relationship, Drug, Chemistry, Rational design, General Chemistry, General Medicine, Acetylcholine, Drug Design, Oocytes, Conotoxins, Algorithms
Published
2014

44. Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant

Author

Dmitry Y. Mordvintsev, Sarah E. van Rossum-Fikkert, Victor I. Tsetlin, René van Elk, August B. Smit, Daniel Bertrand, Maxim N. Zhmak, Titia K. Sixma, Patrick H.N. Celie, Ron C. Hogg, Igor E. Kasheverov, Pim van Nierop, and Molecular and Cellular Neurobiology

Subjects
Models, Molecular, Stereochemistry, Protein Conformation, Xenopus, Molecular Sequence Data, Snails, Nicotinic Antagonists, complex mixtures, Acetylcholine binding, Structural Biology, Muscarinic acetylcholine receptor M5, Animals, Humans, Conotoxin, Amino Acid Sequence, Nicotinic Agonists, Nicotinic Antagonist, Molecular Biology, Acetylcholine receptor, Neurons, Crystallography, Chemistry, Electrophysiology, Nicotinic acetylcholine receptor, Nicotinic agonist, Multiprotein Complexes, Mutation, Oocytes, Alpha-4 beta-2 nicotinic receptor, Carrier Proteins, Conotoxins, Sequence Alignment, Protein Binding
Abstract

Conotoxins (Ctx) form a large family of peptide toxins from cone snail venoms that act on a broad spectrum of ion channels and receptors. The subgroup alpha-Ctx specifically and selectively binds to subtypes of nicotinic acetylcholine receptors (nAChRs), which are targets for treatment of several neurological disorders. Here we present the structure at a resolution of 2.4 A of alpha-Ctx PnIA (A10L D14K), a potent blocker of the alpha(7)-nAChR, bound with high affinity to acetylcholine binding protein (AChBP), the prototype for the ligand-binding domains of the nAChR superfamily. Alpha-Ctx is buried deep within the ligand-binding site and interacts with residues on both faces of adjacent subunits. The toxin itself does not change conformation, but displaces the C loop of AChBP and induces a rigid-body subunit movement. Knowledge of these contacts could facilitate the rational design of drug leads using the Ctx framework and may lead to compounds with increased receptor subtype selectivity.

Published
2005

45. Angular correlations in three-jet events inepcollisions at HERA

Author

A. Raval, Ie. Korol, I. A. Korzhavina, P. Roloff, U. Karshon, Danuta Kisielewska, G. Susinno, T. P. Stewart, P.F. Ermolov, M. Arneodo, Robert Ciesielski, L. M. Shcheglova, B. B. Levchenko, C. Youngman, A. Longhin, Alessandro Polini, P. Stopa, I. Gialas, A. E. Nuncio-Quiroz, J. Grebenyuk, A. Nigro, N. Brümmer, R. Ingbir, R. Yoshida, James Ferrando, P. Göttlicher, O. Behnke, Allen Caldwell, J. Schwartz, G. Grzelak, M. Ruspa, L. Wiggers, E. Gallo, Massimo Corradi, Zainol Abidin Ibrahim, A.S. Proskuryakov, V. Sosnovtsev, J. F. Martin, Ada Solano, T. Namsoo, V. Bokhonov, A. Keramidas, Marcello Bindi, B. Pawlik, Edouard Boos, M. Derrick, T. Tymieniecka, A.G. Yagües-Molina, Masahiro Kuze, Iwona Grabowska-Bold, Tobias M. Haas, D. Gladkov, Antonio Pellegrino, A. N. Barakbaev, V. Schönberg, A. Zichichi, Claire Gwenlan, A.G. Robertson, Mariusz Przybycien, O. Viazlo, F. Januschek, D. Notz, J. M. Pawlak, Z. L. Ren, D.D. Reeder, Kenneth Long, Marco Schioppa, S. Magill, Uta Klein, W. H. Smith, P. G. Pelfer, S. Limentani, J. Del Peso, Y. Ning, J. Repond, D.S. Zotkin, J. Maeda, Yuji Yamazaki, Igor Katkov, C. Zhou, Ramoona Shehzadi, B. Löhr, Denys Lontkovskyi, Marcin Pawel Guzik, A. Stern, Takuya Nobe, A. Parenti, Guenter Wolf, A. Garfagnini, C. D. Catterall, R. J. Nowak, R. Aggarwal, I. Singh, T. Tsurugai, B.O. Zhautykov, Marco Costa, Y. Iga, F. Mohamad Idris, Mykhailo Lisovyi, H.-P. Jakob, K. Oliver, Claudia Glasman, V. Drugakov, Achim Geiser, E. Brownson, W. Perlanski, R.C.E. Devenish, U. Samson, John Hart, B. Brzozowska, Fernando Barreiro, R. Brugnera, O. Yu. Lukina, B. Reisert, Kerstin Borras, T. W. Jones, M.C.K. Mattingly, Juan Terron, Lorenzo Bellagamba, Luca Stanco, Lev Khein, Enrico Tassi, J. J. Whitmore, Dong-Chul Son, J. Tomaszewska, Wojciech Slominski, L. S. Durkin, T. Schörner-Sadenius, Katsuo Tokushuku, S.I. Suchkov, R. Mankel, Wolfgang Lohmann, Graziano Bruni, Oleg Kuprash, J. Szuba, K. Wrona, D. H. Saxon, Orel Gueta, Andrii Verbytskyi, I. Rubinsky, H. Tiecke, S. Antonelli, R. Hamatsu, O. Bachynska, M. Jüngst, Ben Bylsma, D. Szuba, Janusz Chwastowski, Els Koffeman, E. Lohrmann, C. Blohm, Jan Figiel, S. Kananov, S. Fazio, Peter Schleper, G. Hartner, H. Hartmann, S. De Pasquale, V. Aushev, Francois Corriveau, Vladyslav Libov, B. Foster, I. Kadenko, S. Dusini, Grzegorz Gach, M. Adamus, Leszek Adamczyk, Didar Dobur, D. Bot, G. Marini, E. Paul, Shima Shimizu, Wolfram Dietrich Zeuner, A. Bamberger, Alessia Bruni, M.I. Ferrero, Alexander Spiridonov, Ulf Behrens, I. A. Melzer-Pellmann, N. Okazaki, A. Kotański, F. Karstens, E. Hilger, H. Kowalski, Tomasz Bold, Matthew Forrest, Ian Brock, G. Bari, F. J. Sciulli, Y. Aushev, Halina Abramowicz, Alessandro Montanari, F. Cindolo, John Morris, W. A. T. Wan Abdullah, B.Y. Oh, Alexander Tapper, J. Y. Kim, Pietro Antonioli, S. Bhadra, A. Hüttmann, N. Zhmak, Luisa Cifarelli, R. K. Dementiev, K. Mujkic, A. Contin, Alexander Savin, S. Fang, N.S. Pokrovskiy, B. Musgrave, Ewelina Lobodzinska, O. Zenaiev, I. Makarenko, Hartmut Stadie, Valentina Sola, A. Margotti, Zukhaimira Zolkapli, N. Coppola, K. Olkiewicz, H. Wolfe, L. Suszycki, Sebastian Mergelmeyer, Roberto Sacchi, Ingrid-Maria Gregor, Peter Bussey, U. Schneekloth, Anna Mastroberardino, A. Antonov, Masaki Ishitsuka, R. Hori, M. Jimenez, I. O. Skillicorn, Aharon Levy, Amanda Cooper-Sarkar, K. Piotrzkowski, S. Kitamura, M. Zolko, W. B. Schmidke, R. Nania, T. Kanno, Hanno Perrey, G. Dolinska, T. Theedt, Yu. A. Golubkov, K. Papageorgiu, J. Malka, F. Dal Corso, Yu. Onishchuk, U. Noor, Marcella Capua, P. Kooijman, N.N. Vlasov, M. Wlasenko, Silvia Miglioranzi, S. Yamada, Alessandro Bertolin, G. Grigorescu, I. Abt, Boris Dolgoshein, V. Monaco, W. Hain, A. Eskreys, Pawel Plucinski, Janna Katharina Behr, A. F. Żarnecki, Y.D. Ri, A. Galas, A. Salii, D. Hochman, O. Volynets, S. Schlenstedt, L. Zawiejski, M. Turcato, Kunihiro Nagano, G. D'Agostini, M. Vázquez, P. Kaur, Kyrylo Bondarenko, T. Y. Ling, M. Basile, O. Gogota, O. Tomalak, U. Kötz, Robert Klanner, A. Stifutkin, Y. Eisenberg, K. Horton, J. Ciborowski, Giuseppe Barbagli, A. T. Doyle, Manjit Kaur, Matthew Wing, G. Sartorelli, Leonid Gladilin, Roman Walczak, Davide Boscherini, N. Bartosik, J. Sztuk-Dambietz, Sergei Chekanov, Dirk-Uwe Bartsch, B. Kahle, Roberto Carlin, A. Lee, Zeus (IHEF, IoP, FNWI), Precision Frontier, UAM. Departamento de Física Teórica, H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWA, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A.N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, N. BARTOSIK, D. BARTSCH, M. BASILE, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, V. BOKHONOV, T. BOLD, O. BOLILYI, K. BONDARENKO, E.G. BOOS, K. BORRAS, D. BOSCHERINI, D. BOT, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P.J. BUSSEY, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C.D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, L. CIFARELLI, F. CINDOLO, A. CONTIN, A.M. COOPER-SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DEL PESO, R.K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R.C.E. DEVENISH, D. DOBUR, B.A. DOLGOSHEIN, G. DOLINSKA, A.T. DOYLE, V. DRUGAKOV, L.S. DURKIN, S. DUSINI, Y. EISENBERG, P.F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M.I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L.K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, YU.A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA-BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, O. GUETA, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J.C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, R. HORI, K. HORTON, A. HÜTTMANN, Z.A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H.-P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T.W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I.I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L.A. KHEIN, J.Y. KIM, D. KISIELEWSKA1, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, P. KOOIJMAN, I. KOROL, I.A. KORZHAVINA, A. KOTA´ NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, A. LEE, B.B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T.Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, K.R. LONG, A. LONGHIN, D. LONTKOVSKYI, O.YU. LUKINA, P. LU?ZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J.F. MARTIN, A. MASTROBERARDINO, M.C.K. MATTINGLY, I.-A. MELZER PELLMANN, S. MERGELMEYER, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J.D. MORRIS, K. MUJKIC, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, T. NOBE, U. NOOR, D. NOTZ, R.J. NOWAK, A.E. NUNCIO-QUIROZ, B.Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, YU. ONISHCHUK, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J.M. PAWLAK, B. PAWLIK, P.G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N.S. POKROVSKIY, A. POLINI, A.S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D.D. REEDER, B. REISERT, Z. REN1, J. REPOND, Y.D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, G. SARTORELLI, A.A. SAVIN, D.H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W.B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER-SADENIUS, J. SCHWARTZ, F. SCIULLI, L.M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I.O. SKILLICORN, W. SLOMI´ NSKI, W.H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T.P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK-DAMBIETZ, D. SZUBA, J. SZUBA, A.D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE-ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, O. VIAZLO, N.N. VLASOV, O. VOLYNETS, R.WALCZAK, W.A.T. WAN ABDULLAH, J.J.WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K.WRONA, A.G. YAGÜES-MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A.F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B.O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, Z. ZOLKAPLI, M. ZOLKO, and D.S. ZOTKIN

Subjects
Nuclear and High Energy Physics, Particle physics, MONTE-CARLO GENERATOR, ZEUS, DEEP-INELASTIC-SCATTERING, TRIPLE-GLUON VERTEX, QCD COLOR FACTORS, CENTRAL TRACKING DETECTOR, 4-JET FINAL-STATES, LEPTON-NUCLEON SCATTERING, ZEUS BARREL CALORIMETER, C-A/C-F, PARTON DISTRIBUTIONS, FOS: Physical sciences, ep collisions, Symmetry group, Jet (particle physics), 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, ddc:530, 010306 general physics, Physics, Luminosity (scattering theory), 010308 nuclear & particles physics, Scattering, Física, Perturbative QCD, HERA, Deep inelastic scattering, Symmetry (physics), Three-jet production, High Energy Physics::Experiment, ZEUS experiment
Abstract

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM, Three-jet production in deep inelastic ep scattering and photoproduction was investigated with the ZEUS detector at HERA using an integrated luminosity of up to 127pb-1. Measurements of differential cross sections are presented as functions of angular correlations between the three jets in the final state and the proton-beam direction. These correlations provide a stringent test of perturbative QCD and show sensitivity to the contributions from different color configurations. Fixed-order perturbative calculations assuming the values of the color factors CF, CA, and TF as derived from a variety of gauge groups were compared to the measurements to study the underlying gauge group symmetry. The measured angular correlations in the deep inelastic ep scattering and photoproduction regimes are consistent with the admixture of color configurations as predicted by SU(3) and disfavour other symmetry groups, such as SU(N) in the limit of large N, This work was supported by the U.S. Department of Energy, the Italian National Institute for Nuclear Physics (INFN), the German Federal Ministry for Education and Research (BMBF) under Contract No. H09PDF, No. 05h09GUF, and the SFB 676 of the Deutsche Forschungsgemeinschaft (DFG); DESY, Germany; the Science and Technology Facilities Council, United Kingdom; an FRGS grant from the Malaysian government; Presidential grant N-4142.2010.2 for Leading Scientific Schools, by the Russian Ministry of Education and Science through its grant for Scientific Research on High Energy Physics and under Contract No. 02.740.11.0244; the Netherlands Foundation for Research on Matter (FOM); the Israel Science Foundation; the Max Planck Institute for Physics, Munich, Germany; MEIN research grant No. 1 P03B 04529 (2005–2008), Poland; Warsaw University, Poland; the Russian Foundation for Basic Research, Grant 11-02- 91345-DFG_a; the Polish Ministry of Science and Higher Education as a scientific project No. DPN/N188/DESY/ 2009 and its grants for Scientific Research; the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and its grants for Scientific Research; the Korean Ministry of Education and Korea Science and Engineering Foundation; FNRS and its associated funds (IISN and FRIA) and by an Inter-University Attraction Poles Programme subsidized by the Belgian Federal Science Policy Office; the Spanish Ministry of Education and Science through funds provided by CICYT; the Natural Sciences and Engineering Research Council of Canada (NSERC); and the U.S. National Science Foundation

Published
2012

46. Exclusive electroproduction of two pions at HERA

Author

H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWA, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A. N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, N. BARTOSIK, D. BARTSCH, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, V. BOKHONOV, T. BOLD, O. BOLILYI, K. BONDARENKO, E. G. BOOS, K. BORRAS, D. BOSCHERINI, D. BOT, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P. J. BUSSEY, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C. D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, F. CINDOLO, A. M. COOPER SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DEL PESO, R. K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R. C. E. DEVENISH, D. DOBUR, B. A. DOLGOSHEIN, G. DOLINSKA, A. T. DOYLE, V. DRUGAKOV, L. S. DURKIN, S. DUSINI, Y. EISENBERG, P. F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M. I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L. K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, Y.U. A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, O. GUETA, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J. C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, R. HORI, K. HORTON, A. HÜTTMANN, Z. A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H. P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T. W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I. I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L. A. KHEIN, J. Y. KIM, D. KISIELEWSKA1, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, P. KOOIJMAN, I. KOROL, I. A. KORZHAVINA, A. KOTA´ NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, A. LEE, B. B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T. Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, K. R. LONG, A. LONGHIN, D. LONTKOVSKYI, O. Y.U. LUKINA, P. LU?ZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J. F. MARTIN, A. MASTROBERARDINO, M. C. K. MATTINGLY, I. A. MELZER PELLMANN, S. MERGELMEYER, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J. D. MORRIS, K. MUJKIC, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, T. NOBE, U. NOOR, D. NOTZ, R. J. NOWAK, A. E. NUNCIO QUIROZ, B. Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, Y.U. ONISHCHUK, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J. M. PAWLAK, B. PAWLIK, P. G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N. S. POKROVSKIY, A. POLINI, A. S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D. D. REEDER, B. REISERT, Z. REN1, J. REPOND, Y. D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, A. A. SAVIN, D. H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W. B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER SADENIUS, J. SCHWARTZ, F. SCIULLI, L. M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I. O. SKILLICORN, W. SLOMI´ NSKI, W. H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T. P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK DAMBIETZ, D. SZUBA, J. SZUBA, A. D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, O. VIAZLO, N. N. VLASOV, O. VOLYNETS, R. WALCZAK, W. A. T. WAN ABDULLAH, J. J. WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K. WRONA, A. G. YAGÜES MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A. F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B. O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, Z. ZOLKAPLI, M. ZOLKO, D. S. ZOTKIN, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, SARTORELLI, GABRIELLA, Precision Frontier, Zeus (IHEF, IoP, FNWI), H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWA, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A.N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, N. BARTOSIK, D. BARTSCH, M. BASILE, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, V. BOKHONOV, T. BOLD, O. BOLILYI, K. BONDARENKO, E.G. BOOS, K. BORRAS, D. BOSCHERINI, D. BOT, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P.J. BUSSEY, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C.D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, L. CIFARELLI, F. CINDOLO, A. CONTIN, A.M. COOPER-SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DEL PESO, R.K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R.C.E. DEVENISH, D. DOBUR, B.A. DOLGOSHEIN, G. DOLINSKA, A.T. DOYLE, V. DRUGAKOV, L.S. DURKIN, S. DUSINI, Y. EISENBERG, P.F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M.I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L.K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, YU.A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA-BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, O. GUETA, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J.C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, R. HORI, K. HORTON, A. HÜTTMANN, Z.A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H.-P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T.W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I.I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L.A. KHEIN, J.Y. KIM, D. KISIELEWSKA1, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, P. KOOIJMAN, I. KOROL, I.A. KORZHAVINA, A. KOTA´ NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, A. LEE, B.B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T.Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, K.R. LONG, A. LONGHIN, D. LONTKOVSKYI, O.YU. LUKINA, P. LU?ZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J.F. MARTIN, A. MASTROBERARDINO, M.C.K. MATTINGLY, I.-A. MELZER PELLMANN, S. MERGELMEYER, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J.D. MORRIS, K. MUJKIC, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, T. NOBE, U. NOOR, D. NOTZ, R.J. NOWAK, A.E. NUNCIO-QUIROZ, B.Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, YU. ONISHCHUK, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J.M. PAWLAK, B. PAWLIK, P.G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N.S. POKROVSKIY, A. POLINI, A.S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D.D. REEDER, B. REISERT, Z. REN1, J. REPOND, Y.D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, G. SARTORELLI, A.A. SAVIN, D.H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W.B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER-SADENIUS, J. SCHWARTZ, F. SCIULLI, L.M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I.O. SKILLICORN, W. SLOMI´ NSKI, W.H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T.P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK-DAMBIETZ, D. SZUBA, J. SZUBA, A.D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE-ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, O. VIAZLO, N.N. VLASOV, O. VOLYNETS, R.WALCZAK, W.A.T. WAN ABDULLAH, J.J.WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K.WRONA, A.G. YAGÜES-MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A.F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B.O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, Z. ZOLKAPLI, M. ZOLKO, and D.S. ZOTKIN

Subjects
Particle physics, TAU-DECAYS, Physics and Astronomy (miscellaneous), J/PSI MESONS, Nuclear Theory, FOS: Physical sciences, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Pion, Pion em form factor, 0103 physical sciences, SCATTERING, ddc:530, RHO-MESON, CALORIMETER, Nuclear Experiment, 010306 general physics, DIFFRACTIVE ELECTROPRODUCTION, Engineering (miscellaneous), Physics, FORM-FACTOR, 010308 nuclear & particles physics, Two-pion exclusive electroproduction, Sigma, ZEUS, CENTRAL TRACKING DETECTOR, VECTOR-MESON PRODUCTION, PHOTOPRODUCTION, HERA, Vertex (geometry), High Energy Physics::Experiment, ZEUS experiment
Abstract

The exclusive electroproduction of two pions in the mass range 0.4 < M{\pi}{\pi} < 2.5 GeV has been studied with the ZEUS detector at HERA using an integrated luminosity of 82 pb-1. The analysis was carried out in the kinematic range of 2 < Q2 < 80 GeV2, 32 < W < 180 GeV and |t| < 0.6 GeV2, where Q2 is the photon virtuality, W is the photon-proton centre-of-mass energy and t is the squared four-momentum transfer at the proton vertex. The two-pion invariant-mass distribution is interpreted in terms of the pion electromagnetic form factor, |F(M{\pi}{\pi})|, assuming that the studied mass range includes the contributions of the {\rho}, {\rho}' and {\rho}" vector-meson states. The masses and widths of the resonances were obtained and the Q2 dependence of the cross-section ratios {\sigma}({\rho}' \rightarrow {\pi}{\pi})/{\sigma}({\rho}) and {\sigma}({\rho}" \rightarrow {\pi}{\pi})/{\sigma}({\rho}) was extracted. The pion form factor obtained in the present analysis is compared to that obtained in e+e- \rightarrow {\pi}+{\pi}-., Comment: 24 pages, including 11 figures

Published
2012

47. Search for first-generation leptoquarks at HERA

Author

Hanno Perrey, L. M. Shcheglova, Yu. Onishchuk, Yu. A. Golubkov, E. Paul, Tobias M. Haas, R.C.E. Devenish, T. Schörner-Sadenius, Matthew Forrest, P. Kooijman, S. Fazio, Roberto Sacchi, P. Roloff, U. Karshon, R. Ingbir, Iwona Grabowska-Bold, I. Kadenko, Shinichi Shimizu, M. Basile, A. Antonov, M. Arneodo, Robert Ciesielski, A. E. Nuncio-Quiroz, I. Makarenko, G. Susinno, Alexander Spiridonov, I. A. Melzer-Pellmann, W. A. T. Wan Abdullah, J. Schwartz, G. Grzelak, Aharon Levy, T. Namsoo, Valentina Sola, H.-P. Jakob, R. Nania, M. Ruspa, N. Zhmak, T. Kanno, B. B. Levchenko, I. O. Skillicorn, Claire Gwenlan, L. Suszycki, K. Piotrzkowski, F. Januschek, Nazar Stefaniuk, Takuya Nobe, D. Bot, A. Galas, Aleksander Filip Żarnecki, R. Brugnera, A. Contin, Alexander Savin, F. J. Sciulli, V. Schönberg, Alessandro Bertolin, Kerstin Borras, Ulf Behrens, C. Zhou, W. B. Schmidke, M. Jüngst, Ben Bylsma, H. Kowalski, R. Yoshida, D.D. Reeder, D. Szuba, G. Grigorescu, E. Brownson, A. T. Doyle, Ramoona Shehzadi, I. Abt, K. Olkiewicz, Denys Lontkovskyi, O. Behnke, G. D'Agostini, B. A. Dolgoshein, Orel Gueta, Andrii Verbytskyi, Dong-Chul Son, O. Zenaiev, J. F. Martin, M. Vázquez, Kyrylo Bondarenko, T. Y. Ling, Yuji Yamazaki, D. Gladkov, O. Gogota, V. Trusov, Igor Katkov, Mykhailo Lisovyi, H. Wolfe, Vladyslav Libov, Nazar Bartosik, G. Hartner, I. M. Gregor, J. M. Pawlak, Ian Brock, Robert Klanner, Enrico Tassi, J. J. Whitmore, G. Dolinska, J. Szuba, O. Kononenko, H. Hartmann, Guenter Wolf, I. Gialas, J. Tomaszewska, B. Brzozowska, P. Stopa, Y. Eisenberg, Allen Caldwell, K. Papageorgiu, A. Raval, Danuta Kisielewska, T. P. Stewart, A. Keramidas, K. Mujkic, A.S. Proskuryakov, R. Hori, A. Hüttmann, D. H. Saxon, C. Youngman, A. Garfagnini, Alessandro Polini, Giuseppe Barbagli, Kenneth Long, Leszek Adamczyk, B. Musgrave, C. Blohm, Alessia Bruni, V. Monaco, M.I. Ferrero, O. Turkot, W. Hain, F. Karstens, Marcin Pawel Guzik, Hartmut Stadie, G. Sartorelli, J. Grebenyuk, L.W. Wiggers, U. Samson, W. H. Smith, P. Göttlicher, S. De Pasquale, J. Repond, J. Maeda, Mário Costa, Y. Ning, R. Aggarwal, B.O. Zhautykov, Zainol Abidin Ibrahim, K. Horton, M. Derrick, T. Tymieniecka, Y. Iga, Ada Solano, V. Bokhonov, Lorenzo Bellagamba, Ie. Korol, Pawel Plucinski, A. Margotti, A. Eskreys, N. Brümmer, Peter Bussey, M. Kuze, E. Lohrmann, A. Parenti, U. Kötz, T. Tsurugai, R. Mankel, Marcello Bindi, B. Pawlik, Antonio Pellegrino, Y.D. Ri, V. Sosnovtsev, Wolfgang Lohmann, Grzegorz Gach, Graziano Bruni, Halina Abramowicz, John Hart, Jan Figiel, A. N. Barakbaev, I. A. Korzhavina, L. Zawiejski, M. Turcato, A. Stern, W. Slominski, Marco Schioppa, S. Magill, S. Limentani, F. Cindolo, P. G. Pelfer, Matthew Wing, Ozan Arslan, Tomasz Bold, Oleg Kuprash, Katsuo Tokushuku, Janna Katharina Behr, H. Tiecke, Kunihiro Nagano, A. Zichichi, Janusz Chwastowski, I. Rubinsky, D. Notz, D.S. Zotkin, C. D. Catterall, T. W. Jones, I. Singh, Sergei Chekanov, Achim Geiser, R. J. Nowak, Dirk-Uwe Bartsch, P.F. Ermolov, E. Hilger, G. Bari, Juan Terron, P. Kaur, A. Lee, A. Longhin, A. Nigro, James Ferrando, S. Antonelli, E. Gallo, Massimo Corradi, O. Zabiegalov, Francois Corriveau, B.Y. Oh, A. Stifutkin, A. Kotański, A.G. Robertson, Mariusz Przybycien, O. Viazlo, Alexander Tapper, D. Hochman, S. Schlenstedt, N.S. Pokrovskiy, Zukhaimira Zolkapli, Ewelina Lobodzinska, U. Schneekloth, J. Ciborowski, Edouard Boos, S. Fang, Sebastian Mergelmeyer, M.C.K. Mattingly, L. S. Durkin, S. Kitamura, T. Theedt, R. Hamatsu, O. Bachynska, Manjit Kaur, Els Koffeman, Peter Schleper, V. Aushev, K. Wichmann, M. Adamus, G. Marini, Wolfram Dietrich Zeuner, A. Bamberger, Roman Walczak, Uta Klein, Davide Boscherini, Zhongliang Ren, F. Mohamad dris, S. Bhadra, J. Sztuk-Dambietz, K. Oliver, O. Yu. Lukina, B. Reisert, Claudia Glasman, V. Drugakov, B. Kahle, Roberto Carlin, Luca Stanco, Lev Khein, S. Kananov, J. Malka, F. Dal Corso, Marcella Capua, N.N. Vlasov, N. Kondrashova, Masaki Ishitsuka, B. Löhr, K. Wrona, B. Foster, S. Dusini, J. Y. Kim, Pietro Antonioli, Luisa Cifarelli, L. K. Gladilin, R. K. Dementiev, Fernando Barreiro, S.I. Suchkov, Didar Dobur, Y. Aushev, Alessandro Montanari, N. Coppola, A.G. Yagües-Molina, Anna Mastroberardino, Amanda Cooper-Sarkar, J. Del Peso, M. Wlasenko, Silvia Miglioranzi, S. Yamada, A. Gizhko, W. Perlanski, N. Okazaki, John Morris, UAM. Departamento de Física Teórica, Zeus (IHEF, IoP, FNWI), H. Abramowicz, I. Abt, L. Adamczyk, M. Adamu, R. Aggarwal, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, O. Arslan, V. Aushev, Y. Aushev, O. Bachynska, A. Bamberger, A. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, N. Bartosik, D. Bartsch, M. Basile, O. Behnke, J. Behr, U. Behren, L. Bellagamba, A. Bertolin, S. Bhadra, M. Bindi, C. Blohm, V. Bokhonov, T. Bołd, K. Bondarenko, E. Boo, K. Borra, D. Boscherini, D. Bot, I. Brock, E. Brownson, R. Brugnera, N. Brümmer, A. Bruni, G. Bruni, B. Brzozowska, P. Bussey, B. Bylsma, A. Caldwell, M. Capua, R. Carlin, C. Catterall, S. Chekanov, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, A. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, G. D’Agostini, F. Dal Corso, J. del Peso, R. Dementiev, S. De Pasquale, M. Derrick, R. Devenish, D. Dobur, B. Dolgoshein, G. Dolinska, A. Doyle, V. Drugakov, L. Durkin, S. Dusini, Y. Eisenberg, P. Ermolov, A. Eskrey, S. Fang, S. Fazio, J. Ferrando, M. Ferrero, J. Figiel, M. Forrest, B. Foster, G. Gach, A. Gala, E. Gallo, A. Garfagnini, A. Geiser, I. Giala, A. Gizhko, L. Gladilin, D. Gladkov, C. Glasman, O. Gogota, Yu. Golubkov, P. Göttlicher, I. Grabowska-Bołd, J. Grebenyuk, I. Gregor, G. Grigorescu, G. Grzelak, O. Gueta, M. Guzik, C. Gwenlan, T. Haa, W. Hain, R. Hamatsu, J. Hart, H. Hartmann, G. Hartner, E. Hilger, D. Hochman, R. Hori, K. Horton, A. Hüttmann, Z. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, H.-P. Jakob, F. Januschek, T. Jone, M. Jüngst, I. Kadenko, B. Kahle, S. Kananov, T. Kanno, U. Karshon, F. Karsten, I. Katkov, M. Kaur, P. Kaur, A. Keramida, L. Khein, J. Kim, D. Kisielewska, S. Kitamura, R. Klanner, U. Klein, E. Koffeman, N. Kondrashova, O. Kononenko, P. Kooijman, Ie. Korol, I. Korzhavina, A. Kotański, U. Kötz, H. Kowalski, O. Kuprash, M. Kuze, A. Lee, B. Levchenko, A. Levy, V. Libov, S. Limentani, T. Ling, M. Lisovyi, E. Lobodzinska, W. Lohmann, B. Löhr, E. Lohrmann, K. Long, A. Longhin, D. Lontkovskyi, O. Lukina, J. Maeda, S. Magill, I. Makarenko, J. Malka, R. Mankel, A. Margotti, G. Marini, J. Martin, A. Mastroberardino, M. Mattingly, I.-A. Melzer-Pellmann, S. Mergelmeyer, S. Miglioranzi, F. Mohamad dri, V. Monaco, A. Montanari, J. Morri, K. Mujkic, B. Musgrave, K. Nagano, T. Namsoo, R. Nania, A. Nigro, Y. Ning, T. Nobe, D. Notz, R. Nowak, A. Nuncio-Quiroz, B. Oh, N. Okazaki, K. Oliver, K. Olkiewicz, Yu. Onishchuk, K. Papageorgiu, A. Parenti, E. Paul, J. Pawlak, B. Pawlik, P. Pelfer, A. Pellegrino, W. Perlański, H. Perrey, K. Piotrzkowski, P. Pluciński, N. Pokrovskiy, A. Polini, A. Proskuryakov, M. Przybycień, A. Raval, D. Reeder, B. Reisert, Z. Ren, J. Repond, Y. Ri, A. Robertson, P. Roloff, I. Rubinsky, M. Ruspa, R. Sacchi, U. Samson, G. Sartorelli, A. Savin, D. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W. Schmidke, U. Schneekloth, V. Schönberg, T. Schörner-Sadeniu, J. Schwartz, F. Sciulli, L. Shcheglova, R. Shehzadi, S. Shimizu, I. Singh, I. Skillicorn, W. Słomiński, W. Smith, V. Sola, A. Solano, D. Son, V. Sosnovtsev, A. Spiridonov, H. Stadie, L. Stanco, N. Stefaniuk, A. Stern, T. Stewart, A. Stifutkin, P. Stopa, S. Suchkov, G. Susinno, L. Suszycki, J. Sztuk-Dambietz, D. Szuba, J. Szuba, A. Tapper, E. Tassi, J. Terrón, T. Theedt, H. Tiecke, K. Tokushuku, J. Tomaszewska, V. Trusov, T. Tsurugai, M. Turcato, O. Turkot, T. Tymieniecka, M. Vázquez, A. Verbytskyi, O. Viazlo, N. Vlasov, R. Walczak, W. Wan Abdullah, J. Whitmore, K. Wichmann, L. Wigger, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, A. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, O. Zabiegalov, A. Żarnecki, L. Zawiejski, O. Zenaiev, W. Zeuner, B. Zhautykov, N. Zhmak, C. Zhou, A. Zichichi, Z. Zolkapli, and D. Zotkin

Subjects
Exclusion limits, Nuclear and High Energy Physics, Particle physics, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Electron, 01 natural sciences, Standard Model, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), EP COLLISIONS, 0103 physical sciences, ddc:530, Leptoquark, 010306 general physics, Physics, Coupling, PP COLLISIONS, ZEUS (particle detector), Luminosity (scattering theory), ROOT-S=7 TEV, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Yukawa potential, GENERATION SCALAR LEPTOQUARKS, Física, ZEUS, ZEUS BARREL CALORIMETER, HERA, SCATTERING CROSS-SECTIONS, PHYSICS EVENT GENERATION, CENTRAL TRACKING DETECTOR, FERMION-PAIR PRODUCTION, HADRON-COLLISIONS, High Energy Physics::Experiment, ZEUS experiment
Abstract

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM, A search for first-generation leptoquarks was performed in electron-proton and positron-proton collisions recorded with the ZEUS detector at HERA in 2003–2007 using an integrated luminosity of 366 pb-1. Final states with an electron and jets or with missing transverse momentum and jets were analyzed, searching for resonances or other deviations from the standard model predictions. No evidence for any leptoquark signal was found. The data were combined with data previously taken at HERA, resulting in a total integrated luminosity of 498 pb-1. Limits on the Yukawa coupling, λ, of leptoquarks were set as a function of the leptoquark mass for different leptoquark types within the Buchmüller-Rückl-Wyler model. Leptoquarks with a coupling λ = 0.3 are excluded for masses up to 699 GeV, This work was supported by the U.S. Department of Energy; the Italian National Institute for Nuclear Physics (INFN); the German Federal Ministry for Education and Research (BMBF), under Contract No. 05 H09PDF; the Science and Technology Facilities Council, UK; an FRGS grant from the Malaysian government; the U.S. National Science Foundation (any opinion, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation); the Polish Ministry of Science and Higher Education as a scientific project No. DPN/N188/DESY/2009; the Polish Ministry of Science and Higher Education and its grants for Scientific Research; the German Federal Ministry for Education and Research (BMBF), under Contract No. 05h09GUF, and the SFB 676 of the Deutsche Forschungsgemeinschaft (DFG); the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) and its grants for Scientific Research; the Korean Ministry of Education and Korea Science and Engineering Foundation; FNRS and its associated funds (IISN and FRIA) and by an Inter- University Attraction Poles Programme subsidised by the Belgian Federal Science Policy Office; the Spanish Ministry of Education and Science through funds provided by CICYT; the Natural Sciences and Engineering Research Council of Canada (NSERC); supported by the German Federal Ministry for Education and Research (BMBF); R. F. Presidential Grant No. 4142.2010.2 for Leading Scientific Schools, by the Russian Ministry of Education and Science through its grant for Scientific Research on High Energy Physics and under Contract No. 02.740.11.0244; the Netherlands Foundation for Research on Matter (FOM); and the Israel Science Foundation. R. Aggarwal, P. Kaur, and I. Singh were supported by the Max Planck Institute for Physics, Munich, Germany. V. Aushev, Y. Aushev, V. Bokhonov, and N. Zhmak were supported by DESY, Hamburg, Germany. A. Kotanski was supported by the research Grant No. 1 P03B 04529 (2005-2008). W. Słomin´ski was supported by the Polish National Science Centre, Project No. DEC-2011/01/BST2/03643. J. Tomaszewska was partially supported by Warsaw University, Poland. K. Gladilin and I. A. Korzhavina were supported by the Russian Foundation for Basic Research, Grant No. 11-02-91345-DFG_a

Published
2012
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48. Measurement of the t dependence in exclusive photoproduction of $\Upsilon$(1S) mesons at HERA

Author

H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWA, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A. N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, N. BARTOSIK, D. BARTSCH, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, V. BOKHONOV, T. BOLD, O. BOLILYI, K. BONDARENKO, E. G. BOOS, K. BORRAS, D. BOSCHERINI, D. BOT, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P. J. BUSSEY, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C. D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, F. CINDOLO, A. M. COOPER SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DEL PESO, R. K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R. C. E. DEVENISH, D. DOBUR, B. A. DOLGOSHEIN, G. DOLINSKA, A. T. DOYLE, V. DRUGAKOV, L. S. DURKIN, S. DUSINI, Y. EISENBERG, P. F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M. I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L. K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, Y.U. A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, O. GUETA, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J. C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, R. HORI, K. HORTON, A. HÜTTMANN, Z. A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H. P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T. W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I. I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L. A. KHEIN, J. Y. KIM, D. KISIELEWSKA1, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, P. KOOIJMAN, I. KOROL, I. A. KORZHAVINA, A. KOTA´ NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, A. LEE, B. B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T. Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, K. R. LONG, A. LONGHIN, D. LONTKOVSKYI, O. Y.U. LUKINA, P. LU?ZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J. F. MARTIN, A. MASTROBERARDINO, M. C. K. MATTINGLY, I. A. MELZER PELLMANN, S. MERGELMEYER, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J. D. MORRIS, K. MUJKIC, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, T. NOBE, U. NOOR, D. NOTZ, R. J. NOWAK, A. E. NUNCIO QUIROZ, B. Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, Y.U. ONISHCHUK, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J. M. PAWLAK, B. PAWLIK, P. G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N. S. POKROVSKIY, A. POLINI, A. S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D. D. REEDER, B. REISERT, Z. REN1, J. REPOND, Y. D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, A. A. SAVIN, D. H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W. B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER SADENIUS, J. SCHWARTZ, F. SCIULLI, L. M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I. O. SKILLICORN, W. SLOMI´ NSKI, W. H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T. P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK DAMBIETZ, D. SZUBA, J. SZUBA, A. D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, O. VIAZLO, N. N. VLASOV, O. VOLYNETS, R. WALCZAK, W. A. T. WAN ABDULLAH, J. J. WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K. WRONA, A. G. YAGÜES MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A. F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B. O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, Z. ZOLKAPLI, M. ZOLKO, D. S. ZOTKIN, BASILE, MAURIZIO, CIFARELLI, LUISA, CONTIN, ANDREA, SARTORELLI, GABRIELLA, H. ABRAMOWICZ, I. ABT, L. ADAMCZYK, M. ADAMUS, R. AGGARWA, S. ANTONELLI, P. ANTONIOLI, A. ANTONOV, M. ARNEODO, V. AUSHEV, Y. AUSHEV, O. BACHYNSKA, A. BAMBERGER, A.N. BARAKBAEV, G. BARBAGLI, G. BARI, F. BARREIRO, N. BARTOSIK, D. BARTSCH, M. BASILE, O. BEHNKE, J. BEHR, U. BEHRENS, L. BELLAGAMBA, A. BERTOLIN, S. BHADRA, M. BINDI, C. BLOHM, V. BOKHONOV, T. BOLD, O. BOLILYI, K. BONDARENKO, E.G. BOOS, K. BORRAS, D. BOSCHERINI, D. BOT, I. BROCK, E. BROWNSON, R. BRUGNERA, N. BRÜMMER, A. BRUNI, G. BRUNI, B. BRZOZOWSKA, P.J. BUSSEY, B. BYLSMA, A. CALDWELL, M. CAPUA, R. CARLIN, C.D. CATTERALL, S. CHEKANOV, J. CHWASTOWSKI, J. CIBOROWSKI, R. CIESIELSKI, L. CIFARELLI, F. CINDOLO, A. CONTIN, A.M. COOPER-SARKAR, N. COPPOLA, M. CORRADI, F. CORRIVEAU, M. COSTA, G. D’AGOSTINI, F. DAL CORSO, J. DEL PESO, R.K. DEMENTIEV, S. DE PASQUALE, M. DERRICK, R.C.E. DEVENISH, D. DOBUR, B.A. DOLGOSHEIN, G. DOLINSKA, A.T. DOYLE, V. DRUGAKOV, L.S. DURKIN, S. DUSINI, Y. EISENBERG, P.F. ERMOLOV, A. ESKREYS, S. FANG, S. FAZIO, J. FERRANDO, M.I. FERRERO, J. FIGIEL, M. FORREST, B. FOSTER, S. FOURLETOV, G. GACH, A. GALAS, E. GALLO, A. GARFAGNINI, A. GEISER, I. GIALAS, L.K. GLADILIN, D. GLADKOV, C. GLASMAN, O. GOGOTA, YU.A. GOLUBKOV, P. GÖTTLICHER, I. GRABOWSKA-BOLD, J. GREBENYUK, I. GREGOR, G. GRIGORESCU, G. GRZELAK, O. GUETA, C. GWENLAN, T. HAAS, W. HAIN, R. HAMATSU, J.C. HART, H. HARTMANN, G. HARTNER, E. HILGER, D. HOCHMAN, R. HORI, K. HORTON, A. HÜTTMANN, Z.A. IBRAHIM, Y. IGA, R. INGBIR, M. ISHITSUKA, H.-P. JAKOB, F. JANUSCHEK, M. JIMENEZ, T.W. JONES, M. JÜNGST, I. KADENKO, B. KAHLE, B. KAMALUDDIN, S. KANANOV, T. KANNO, U. KARSHON, F. KARSTENS, I.I. KATKOV, M. KAUR, P. KAUR, A. KERAMIDAS, L.A. KHEIN, J.Y. KIM, D. KISIELEWSKA1, S. KITAMURA, R. KLANNER, U. KLEIN, E. KOFFEMAN, P. KOOIJMAN, I. KOROL, I.A. KORZHAVINA, A. KOTA´ NSKI, U. KÖTZ, H. KOWALSKI, P. KULINSKI, O. KUPRASH, M. KUZE, A. LEE, B.B. LEVCHENKO, A. LEVY, V. LIBOV, S. LIMENTANI, T.Y. LING, M. LISOVYI, E. LOBODZINSKA, W. LOHMANN, B. LÖHR, E. LOHRMANN, K.R. LONG, A. LONGHIN, D. LONTKOVSKYI, O.YU. LUKINA, P. LU?ZNIAK, J. MAEDA, S. MAGILL, I. MAKARENKO, J. MALKA, R. MANKEL, A. MARGOTTI, G. MARINI, J.F. MARTIN, A. MASTROBERARDINO, M.C.K. MATTINGLY, I.-A. MELZER PELLMANN, S. MERGELMEYER, S. MIGLIORANZI, F. MOHAMAD IDRIS, V. MONACO, A. MONTANARI, J.D. MORRIS, K. MUJKIC, B. MUSGRAVE, K. NAGANO, T. NAMSOO, R. NANIA, D. NICHOLASS, A. NIGRO, Y. NING, T. NOBE, U. NOOR, D. NOTZ, R.J. NOWAK, A.E. NUNCIO-QUIROZ, B.Y. OH, N. OKAZAKI, K. OLIVER, K. OLKIEWICZ, YU. ONISHCHUK, K. PAPAGEORGIU, A. PARENTI, E. PAUL, J.M. PAWLAK, B. PAWLIK, P.G. PELFER, A. PELLEGRINO, W. PERLANSKI, H. PERREY, K. PIOTRZKOWSKI, P. PLUCINSKI, N.S. POKROVSKIY, A. POLINI, A.S. PROSKURYAKOV, M. PRZYBYCIE´N, A. RAVAL, D.D. REEDER, B. REISERT, Z. REN1, J. REPOND, Y.D. RI, A. ROBERTSON, P. ROLOFF, E. RON, I. RUBINSKY, M. RUSPA, R. SACCHI, A. SALII, U. SAMSON, G. SARTORELLI, A.A. SAVIN, D.H. SAXON, M. SCHIOPPA, S. SCHLENSTEDT, P. SCHLEPER, W.B. SCHMIDKE, U. SCHNEEKLOTH, V. SCHÖNBERG, T. SCHÖRNER-SADENIUS, J. SCHWARTZ, F. SCIULLI, L.M. SHCHEGLOVA, R. SHEHZADI, S. SHIMIZU, I. SINGH, I.O. SKILLICORN, W. SLOMI´ NSKI, W.H. SMITH, V. SOLA, A. SOLANO, D. SON, V. SOSNOVTSEV, A. SPIRIDONOV, H. STADIE, L. STANCO, A. STERN, T.P. STEWART, A. STIFUTKIN, P. STOPA, S. SUCHKOV, G. SUSINNO, L. SUSZYCKI, J. SZTUK-DAMBIETZ, D. SZUBA, J. SZUBA, A.D. TAPPER, E. TASSI, J. TERRÓN, T. THEEDT, H. TIECKE, K. TOKUSHUKU, O. TOMALAK, J. TOMASZEWSKA, T. TSURUGAI, M. TURCATO, T. TYMIENIECKA, C. URIBE-ESTRADA, M. VÁZQUEZ, A. VERBYTSKYI, O. VIAZLO, N.N. VLASOV, O. VOLYNETS, R.WALCZAK, W.A.T. WAN ABDULLAH, J.J.WHITMORE, J. WHYTE, L. WIGGERS, M. WING, M. WLASENKO, G. WOLF, H. WOLFE, K.WRONA, A.G. YAGÜES-MOLINA, S. YAMADA, Y. YAMAZAKI, R. YOSHIDA, C. YOUNGMAN, A.F. ZARNECKI, L. ZAWIEJSKI, O. ZENAIEV, W. ZEUNER, B.O. ZHAUTYKOV, N. ZHMAK, C. ZHOU, A. ZICHICHI, Z. ZOLKAPLI, M. ZOLKO, and D.S. ZOTKIN

Subjects
High Energy Physics - Experiment (hep-ex), Upsilon(1S) photoproduction, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, High Energy Physics::Experiment, ep collisions, ddc:530, Nuclear Experiment, High Energy Physics - Experiment, ZEUS experiment
Abstract

The exclusive photoproduction reaction gamma p -> Upsilon(1S) p has been studied with the ZEUS detector in ep collisions at HERA using an integrated luminosity of 468 pb^-1. The measurement covers the kinematic range 60 Upsilon(1S) p cross section., Comment: 15 pages, 4 figures; http://dx.doi.org/10.1016/j.physletb.2012.01.009

Published
2012

49. Combined inclusive diffractive cross sections measured with forward proton spectrometers in deep inelastic ep scattering at HERA

Author

Murrough Landon, J. M. Pawlak, K. Lipka, Takuya Nobe, D. Wegener, A. Garfagnini, Shima Shimizu, Tobias M. Haas, U. Samson, P. Van Mechelen, A. Raval, Alexandre Lebedev, Stephen Maxfield, Tomasz Bold, Mykhailo Lisovyi, Shoichi Yamada, S. Shushkevich, P. Sopicki, J. Žáček, T.H. Tran, Katsuo Tokushuku, M. Jüngst, Ben Bylsma, Danuta Kisielewska, D. Szuba, R.C.E. Devenish, D.D. Reeder, Ramoona Shehzadi, Adrian Stern, A. Pellegrino, T. Schörner-Sadenius, Ingrid-Maria Gregor, J. Zálešák, Andrew Mehta, V. Spaskov, F. Huber, C. Pascaud, Max Klein, A. B. Meyer, D. Traynor, J. Ciborowski, Yu. A. Golubkov, T. P. Stewart, J. Malka, G. Hartner, E. Paul, Ie. Korol, Anna Mastroberardino, A. Eliseev, T. Namsoo, N. Gogitidze, H. Hartmann, B. B. Levchenko, E. Barrelet, M.C.K. Mattingly, L. S. Durkin, Amanda Cooper-Sarkar, C. Youngman, Iwona Grabowska-Bold, R. Hamatsu, O. Bachynska, T. W. Jones, A.G. Robertson, S. Habib, O. Turkot, Hans-Christian Schultz-Coulon, B. Stella, L. M. Shcheglova, Andrea Contin, Mariusz Przybycien, O. Viazlo, Janusz Chwastowski, Alessandro Polini, Z. Staykova, Paul Laycock, J. F. Martin, Alexander Bylinkin, Els Koffeman, Calin Alexa, G. D'Agostini, H. U. Martyn, J. E. Ruiz Tabasco, E. A. De Wolf, A. M. Fomenko, A. Antonov, S. Mikocki, R. Roosen, Dieter H. H. Hoffmann, Matthew Forrest, Peter Schleper, V. Aushev, Rosario Nania, E. Malinovski, Manjit Kaur, Stefan Schmitt, M. Dobre, Vladyslav Libov, Kyrylo Bondarenko, T. Y. Ling, Emmanuel Sauvan, Pavel A. Belov, P.M. Kooijman, E. Perez, G. Grindhammer, D. Gladkov, H. Henschel, Robert Henderson, D. Hochman, K. Wichmann, M. Adamus, S. Ghazaryan, G. Marini, Wolfram Dietrich Zeuner, Achim Geiser, V. P. Andreev, Halina Abramowicz, Ada Solano, Alexander Spiridonov, I. A. Melzer-Pellmann, I. A. Korzhavina, Fabian Zomer, A. Bamberger, T. J. Sloan, A.S. Belousov, Sergey Rusakov, Robert Klanner, L. Stanco, K. Mujkic, Leonid Gladilin, R. Ingbir, Y. Vazdik, S. Schlenstedt, V. Schönberg, V. Bokhonov, P. Göttlicher, Davide Boscherini, Ian Brock, G. Herrera, Guenter Wolf, Claus Kleinwort, Marcella Capua, P. Truöl, E. Hilger, E.G. Boos, Gabriel Stoicea, E. E. Elsen, K. Krüger, K. Daum, V. Sosnovtsev, Y. Soloviev, B. Brzozowska, Roland Horisberger, Juan Terron, P. Stopa, S. Bhadra, S. Limentani, B.O. Zhautykov, Cristinel Diaconu, O. Zenaiev, B. Delcourt, Marco Costa, Michele Arneodo, A. Valkárová, D. Ozerov, A. Keramidas, B. Musgrave, Tomas Hreus, Laurent Favart, U. Straumann, Pawel Plucinski, B.Y. Oh, J. Feltesse, Y. Iga, Ricardo Lopez-Fernandez, W. Perlanski, A. Specka, Valentina Sola, D. H. Saxon, Thomas Naumann, V. Lubimov, Hannes Jung, Vladimir Palichik, P.F. Ermolov, A. Hüttmann, John Hart, A. Bertolin, Lorenzo Bellagamba, D. J. Fischer, Nazar Stefaniuk, N.N. Vlasov, Jan Figiel, L. Suszycki, Alexander Zhokin, S. Antonelli, Marco Schioppa, P. G. Pelfer, N.S. Pokrovskiy, M. Steder, Oleg Kuprash, Grzegorz Nowak, H.-P. Jakob, I. Gialas, A. E. Nuncio-Quiroz, Giuseppe Barbagli, A. Schöning, Anselmo Margotti, J. Grebenyuk, L.W. Wiggers, Zukhaimira Zolkapli, A. Dossanov, I. Makarenko, E. Lohrmann, I. Rubinsky, Masahiro Kuze, I. Singh, L. Zawiejski, Y.D. Ri, M. Turcato, P. D. Thompson, A. Dubak, D.K. Nikitin, G. Grigorescu, A. Galas, A. Petrukhin, Sergei Chekanov, R. Brugnera, N. Okazaki, Ulf Behrens, Federico Cindolo, H. Kowalski, John Morris, I. O. Skillicorn, Allen Caldwell, Grzegorz Gach, Federico Alberto Ceccopieri, Tim Greenshaw, Kunihiro Nagano, K. B. Cantun Avila, J. E. Olsson, Y. Eisenberg, W. Bartel, Robert Ciesielski, M. Brinkmann, W. Slominski, B. Tseepeldorj, M. Jacquet, James Ferrando, Kenneth Long, Dirk-Uwe Bartsch, Kerstin Borras, Dong-Chul Son, I. Picuric, G. Bari, Claudia Glasman, V. Drugakov, P. Roloff, M. Kapichine, Roberto Sacchi, C. Kiesling, V. Trusov, W. A. T. Wan Abdullah, B. Löhr, F. Moreau, J. Hladký, B. Lobodzinski, Karl Heinz Hiller, Yuji Yamazaki, Malte Hildebrandt, R. Walczak, F. Dal Corso, Zainol Abidin Ibrahim, T. Tymieniecka, A.G. Yagües-Molina, A. Parenti, O. Gogota, Elisabetta Gallo, U. Kötz, L. N. Shtarkov, Yu. Onishchuk, Igor Katkov, S. Magill, A. J. Campbell, U. Karshon, Daniel Pitzl, Lev Khein, Karel Cerny, J. Maeda, Guenter Eckerlin, I. R. Kenyon, J. Cvach, I. Milcewicz-Mika, O. Kononenko, A. Lee, L. Goerlich, G. Susinno, P. Kaur, Natasa Raicevic, P. Kostka, M. Wlasenko, Af Zarnecki, Aharon Levy, R. J. Nowak, D. Bot, K. Wrona, J. Tomaszewska, Anastasia Grebenyuk, S. Kananov, B. Foster, V. Radescu, Paul Newman, S. Dusini, Ewelina Lobodzinska, O. Behnke, G. Sartorelli, K. Müller, John A Coughlan, V. Lendermann, V. Brisson, Mila Pandurovic, Gerhard Brandt, A. Stifutkin, G. Laštovička-Medin, J. Turnau, Silvia Miglioranzi, Juraj Bracinik, J. Sztuk-Dambietz, A. N. Morozov, Roman Kogler, Ozan Arslan, J.C. Bizot, C. Blohm, J. Y. Kim, R. Placakyte, I. Bozovic-Jelisavcic, Zhiqing Zhang, K. Begzsuren, I. Tsakov, K. Olkiewicz, U. Schneekloth, V. Chekelian, H. Wolfe, Z. L. Ren, Daniel Britzger, E. Hennekemper, S. Fang, Sebastian Mergelmeyer, Pietro Antonioli, A.S. Proskuryakov, F. J. Sciulli, Luisa Cifarelli, R. Felst, R. K. Dementiev, A. Gizhko, N. Brümmer, P. Pahl, R. Žlebčík, E. Gabathuler, Tomas Sykora, M. Sauter, N. Kondrashova, Marcin Pawel Guzik, H. Perrey, Alexandre Glazov, T. Tsurugai, M. Basile, S. Kitamura, R. Hori, A. T. Doyle, Jan Kretzschmar, D. Salek, Leif J. Jönsson, Matthew Wing, B. Pokorny, R. Mankel, R. Aggarwal, Wolfgang Lohmann, B. Kahle, A. Zichichi, Graziano Bruni, Roberto Carlin, M. Fleischer, T. Kanno, T. Theedt, Hartmut Stadie, J. B. Dainton, E. Brownson, J. Del Peso, V. Boudry, J. G. Contreras, Masaki Ishitsuka, Francois Corriveau, Orel Gueta, Andrii Verbytskyi, D. Notz, Marta Ruspa, D.S. Zotkin, C. D. Catterall, A. Kotański, Xavier Janssen, A. Longhin, Alexander Tapper, C. Niebuhr, K. Nowak, Bogdan Povh, F. Sefkow, S. Egli, A. Nigro, J-P. Meyer, Maxime Gouzevitch, N. Coppola, Massimo Corradi, O. Zabiegalov, Fernando Barreiro, S.I. Suchkov, Christoph Grab, S. Fazio, David M. South, Marina Rotaru, Uta Klein, Didar Dobur, A. Baghdasaryan, Y. Aushev, Alessandro Montanari, S. Levonian, B. Reisert, H.G.J.M. Tiecke, I. Kadenko, Dusan Bruncko, N. Zhmak, T. Ravdandorj, A. Rostovtsev, Alexander Savin, Richard Polifka, J. Szuba, F. D. Aaron, M. Derrick, Peter Robmann, E. Wünsch, Dave Sankey, Leszek Adamczyk, J. Delvax, Alessia Bruni, M.I. Ferrero, G. D. Patel, H. Meyer, F. Karstens, S. Backovic, Michael Kramer, Olga Lukina, C. Vallée, Denys Lontkovskyi, D. Haidt, A. Eskreys, Eram Rizvi, Nazar Bartosik, V. Dodonov, Enrico Tassi, J. J. Whitmore, Janna Katharina Behr, J. Schwartz, J. V. Morris, G. Grzelak, Jenny List, S. Baghdasaryan, M. Vázquez, A. Bunyatyan, Claire Gwenlan, F. Januschek, S. De Pasquale, Wolfgang Lange, W. B. Schmidke, I. Abt, J. Gayler, G. Dolinska, K. Papageorgiu, H. Pirumov, Boris Dolgoshein, A. V. Fedotov, V. Monaco, W. Hain, L. Bystritskaya, H. Zohrabyan, Peter Bussey, W. H. Smith, Y. Ning, Marcello Bindi, B. Pawlik, A. N. Barakbaev, V. Cerny, Benno List, F. Mohamad Idris, P. E. Reimer, J. Repond, Krzysztof Piotrzkowski, M. Herbst, R. Yoshida, J. Ferencei, Laurent Schoeffel, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H1, ZEUS, F. D. Aaron, H. Abramowicz, I. Abt, L. Adamczyk, M. Adamu, R. Aggarwal, C. Alexa, V. Andreev, S. Antonelli, P. Antonioli, A. Antonov, M. Arneodo, O. Arslan, V. Aushev, Y. Aushev, O. Bachynska, S. Backovic, A. Baghdasaryan, S. Baghdasaryan, A. Bamberger, A. N. Barakbaev, G. Barbagli, G. Bari, F. Barreiro, E. Barrelet, W. Bartel, N. Bartosik, D. Bartsch, M. Basile, K. Begzsuren, O. Behnke, J. Behr, U. Behren, L. Bellagamba, A. Belousov, P. Belov, A. Bertolin, S. Bhadra, M. Bindi, J. C. Bizot, C. Blohm, V. Bokhonov, K. Bondarenko, E. G. Boo, K. Borra, D. Boscherini, D. Bot, V. Boudry, I. Bozovic-Jelisavcic, T. Bołd, N. Brümmer, J. Bracinik, G. Brandt, M. Brinkmann, V. Brisson, D. Britzger, I. Brock, E. Brownson, R. Brugnera, D. Bruncko, A. Bruni, G. Bruni, B. Brzozowska, A. Bunyatyan, P. J. Bussey, A. Bylinkin, B. Bylsma, L. Bystritskaya, A. Caldwell, A. J. Campbell, K. B. Cantun Avila, M. Capua, R. Carlin, C. D. Catterall, F. Ceccopieri, K. Cerny, V. Cerny, S. Chekanov, V. Chekelian, J. Chwastowski, J. Ciborowski, R. Ciesielski, L. Cifarelli, F. Cindolo, A. Contin, J. G. Contrera, A. M. Cooper-Sarkar, N. Coppola, M. Corradi, F. Corriveau, M. Costa, J. A. Coughlan, J. Cvach, G. D’Agostini, J. B. Dainton, F. Dal Corso, K. Daum, B. Delcourt, J. Delvax, R. K. Dementiev, M. Derrick, R. C. E. Devenish, S. Pasquale, E. A. Wolf, J. Peso, C. Diaconu, M. Dobre, D. Dobur, V. Dodonov, B. A. Dolgoshein, G. Dolinska, A. Dossanov, A. T. Doyle, V. Drugakov, A. Dubak, L. S. Durkin, S. Dusini, G. Eckerlin, S. Egli, Y. Eisenberg, A. Eliseev, E. Elsen, P. F. Ermolov, A. Eskrey, S. Fang, L. Favart, S. Fazio, A. Fedotov, R. Felst, J. Feltesse, J. Ferencei, J. Ferrando, M. I. Ferrero, J. Figiel, D.-J. Fischer, M. Fleischer, A. Fomenko, M. Forrest, B. Foster, E. Gabathuler, G. Gach, A. Gala, E. Gallo, A. Garfagnini, J. Gayler, A. Geiser, S. Ghazaryan, I. Giala, A. Gizhko, L. K. Gladilin, D. Gladkov, C. Glasman, A. Glazov, L. Goerlich, N. Gogitidze, O. Gogota, Y. A. Golubkov, P. Göttlicher, M. Gouzevitch, C. Grab, I. Grabowska-Bołd, A. Grebenyuk, J. Grebenyuk, T. Greenshaw, I. Gregor, G. Grigorescu, G. Grindhammer, G. Grzelak, O. Gueta, M. Guzik, C. Gwenlan, A. Hüttmann, T. Haa, S. Habib, D. Haidt, W. Hain, R. Hamatsu, J. C. Hart, H. Hartmann, G. Hartner, R. C. W. Henderson, E. Hennekemper, H. Henschel, M. Herbst, G. Herrera, M. Hildebrandt, E. Hilger, K. H. Hiller, J. Hladký, D. Hochman, D. Hoffmann, R. Hori, R. Horisberger, T. Hreu, F. Huber, Z. A. Ibrahim, Y. Iga, R. Ingbir, M. Ishitsuka, M. Jacquet, H.-P. Jakob, X. Janssen, F. Januschek, T. W. Jone, L. Jönsson, M. Jüngst, H. Jung, I. Kadenko, B. Kahle, S. Kananov, T. Kanno, M. Kapichine, U. Karshon, F. Karsten, I. I. Katkov, P. Kaur, M. Kaur, I. R. Kenyon, A. Keramida, L. A. Khein, C. Kiesling, J. Y. Kim, D. Kisielewska, S. Kitamura, R. Klanner, M. Klein, U. Klein, C. Kleinwort, E. Koffeman, R. Kogler, N. Kondrashova, O. Kononenko, P. Kooijman, I. Korol, I. A. Korzhavina, P. Kostka, A. Kotański, U. Kötz, H. Kowalski, M. Krämer, J. Kretzschmar, K. Krüger, O. Kuprash, M. Kuze, M. P. J. Landon, W. Lange, G. Laštovička-Medin, P. Laycock, A. Lebedev, A. Lee, V. Lendermann, B. B. Levchenko, S. Levonian, A. Levy, V. Libov, S. Limentani, T. Y. Ling, K. Lipka, M. Lisovyi, B. List, J. List, E. Lobodzinska, B. Lobodzinski, W. Lohmann, B. Löhr, E. Lohrmann, K. R. Long, A. Longhin, D. Lontkovskyi, R. Lopez-Fernandez, V. Lubimov, O. Y. Lukina, J. Maeda, S. Magill, I. Makarenko, E. Malinovski, J. Malka, R. Mankel, A. Margotti, G. Marini, J. F. Martin, H.-U. Martyn, A. Mastroberardino, M. C. K. Mattingly, S. J. Maxfield, A. Mehta, I.-A. Melzer-Pellmann, S. Mergelmeyer, A. B. Meyer, H. Meyer, J. Meyer, S. Miglioranzi, S. Mikocki, I. Milcewicz-Mika, F. Mohamad Idri, V. Monaco, A. Montanari, F. Moreau, A. Morozov, J. V. Morri, J. D. Morri, K. Mujkic, K. Müller, B. Musgrave, K. Nagano, T. Namsoo, R. Nania, T. Naumann, P. R. Newman, C. Niebuhr, A. Nigro, D. Nikitin, Y. Ning, T. Nobe, D. Notz, G. Nowak, K. Nowak, R. J. Nowak, A. E. Nuncio-Quiroz, B. Y. Oh, N. Okazaki, K. Olkiewicz, J. E. Olsson, Y. Onishchuk, D. Ozerov, P. Pahl, V. Palichik, M. Pandurovic, K. Papageorgiu, A. Parenti, C. Pascaud, G. D. Patel, E. Paul, J. M. Pawlak, B. Pawlik, P. G. Pelfer, A. Pellegrino, E. Perez, W. Perlański, H. Perrey, A. Petrukhin, I. Picuric, K. Piotrzkowski, H. Pirumov, D. Pitzl, R. Plačakytė, P. Pluciński, B. Pokorny, N. S. Pokrovskiy, R. Polifka, A. Polini, B. Povh, A. S. Proskuryakov, M. Przybycień, V. Radescu, N. Raicevic, A. Raval, T. Ravdandorj, D. D. Reeder, P. Reimer, B. Reisert, Z. Ren, J. Repond, Y. D. Ri, E. Rizvi, A. Robertson, P. Robmann, P. Roloff, R. Roosen, A. Rostovtsev, M. Rotaru, I. Rubinsky, J. E. Ruiz Tabasco, S. Rusakov, M. Ruspa, R. Sacchi, D. Šálek, U. Samson, D. P. C. Sankey, G. Sartorelli, M. Sauter, E. Sauvan, A. A. Savin, D. H. Saxon, M. Schioppa, S. Schlenstedt, P. Schleper, W. B. Schmidke, S. Schmitt, U. Schneekloth, L. Schoeffel, V. Schönberg, A. Schöning, T. Schörner-Sadeniu, H.-C. Schultz-Coulon, J. Schwartz, F. Sciulli, F. Sefkow, L. M. Shcheglova, R. Shehzadi, S. Shimizu, L. N. Shtarkov, S. Shushkevich, I. Singh, I. O. Skillicorn, W. Słomiński, T. Sloan, W. H. Smith, V. Sola, A. Solano, Y. Soloviev, D. Son, P. Sopicki, V. Sosnovtsev, D. South, V. Spaskov, A. Specka, A. Spiridonov, H. Stadie, L. Stanco, Z. Staykova, M. Steder, N. Stefaniuk, B. Stella, A. Stern, T. P. Stewart, A. Stifutkin, G. Stoicea, P. Stopa, U. Straumann, S. Suchkov, G. Susinno, L. Suszycki, T. Sykora, J. Sztuk-Dambietz, J. Szuba, D. Szuba, A. D. Tapper, E. Tassi, J. Terrón, T. Theedt, P. D. Thompson, H. Tiecke, K. Tokushuku, J. Tomaszewska, T. H. Tran, D. Traynor, P. Truöl, V. Trusov, I. Tsakov, B. Tseepeldorj, T. Tsurugai, M. Turcato, O. Turkot, J. Turnau, T. Tymieniecka, M. Vázquez, A. Valkárová, C. Vallée, P. Mechelen, Y. Vazdik, A. Verbytskyi, O. Viazlo, N. N. Vlasov, R. Walczak, W. A. T. Wan Abdullah, D. Wegener, J. J. Whitmore, K. Wichmann, L. Wigger, M. Wing, M. Wlasenko, G. Wolf, H. Wolfe, K. Wrona, E. Wünsch, A. G. Yagües-Molina, S. Yamada, Y. Yamazaki, R. Yoshida, C. Youngman, O. Zabiegalov, J. Žáček, J. Zálešák, L. Zawiejski, O. Zenaiev, W. Zeuner, Z. Zhang, B. O. Zhautykov, N. Zhmak, A. Zhokin, A. Zichichi, R. Žlebčík, H. Zohrabyan, Z. Zolkapli, F. Zomer, D. S. Zotkin, A. F. Żarnecki, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), H1 Collaboration, ZEUS Collaboration, Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Zeus (IHEF, IoP, FNWI), and ZEUS Collaboration (ukupan broj autora: 500)

Subjects
Particle physics, Physics and Astronomy (miscellaneous), Proton, Leading proton spectrometers, Hadron, HERA, FOS: Physical sciences, Inelastic scattering, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], ddc:530, Nuclear Experiment, 010306 general physics, Engineering (miscellaneous), ZEUS and H1 experiment, Physics, ZEUS (particle detector), 010308 nuclear & particles physics, Scattering, Inclusive diffractive cross section, ZEUS, Deep inelastic scattering, Proton Spectrometers, Physique des particules élémentaires, H1, Diffraction, High Energy Physics::Experiment, Nucleon
Abstract

A combination of the inclusive diffractive cross section measurements made by the H1 and ZEUS Collaborations at HERA is presented. The analysis uses samples of diffractive deep inelastic ep scattering data at a centre-of-mass energy √s= 318 Gev where leading protons are detected by dedicated spectrometers. Correlations of systematic uncertainties are taken into account, resulting in an improved precision of the cross section measurement which reaches 6 % for the most precise points. The combined data cover the range 2.5 < Q 2 < 200 GeV 2 in photon virtuality, 0.00035 < xP < 0.09 in proton fractional momentum loss, 0.09, 0, H1 and ZEUS Collaborations, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2012

50. Induction of Immune Response by Synthetic Fragments of the Bovine Prion Protein and Their Analogues in Mice of Various Lines

Author

T. D. Volkova, M. A. Titova, Oboznaia Mb, Vadim T. Ivanov, S. S. Rybakov, Olga M. Volpina, Maxim N. Zhmak, and Egorov Aa

Subjects
chemistry.chemical_classification, biology, Chemistry, animal diseases, Organic Chemistry, Biochemistry, Molecular biology, Amino acid, Specific antibody, Immune system, Immunization, biology.protein, Bioorganic chemistry, Immunohistochemistry, Antibody, Prion protein
Abstract

Antibodies to the bovine prion protein were produced by immunizing mice of three lines with five synthetic fragments of the protein and six of their analogues. The analogues contained amino acid substitutions that, according to theoretical calculation, should lead to an increase in the immunogenic activity of peptides. All the peptides except for one induced the formation of antibodies. All the sera containing the antipeptide antibodies were tested by an immunohistochemical method. The sera effectively bound to brain preparations from an animal with spongiform encephalopathy were identified; it was shown that they do not interact with preparations of normal brain. Therefore, it was shown that the immunization of mice with synthetic fragments of a prion protein allows one to obtain specific antibodies suitable for the study and diagnostics of prion diseases.

Published
2004

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