16 results on '"N. Yu. Vasilyeva"'
Search Results
2. Sulfation of wheat straw soda lignin: Role of solvents and catalysts
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Valentina S. Borovkova, Angelina V. Miroshnikova, A. V. Levdansky, A. S. Kazachenko, O. Yu. Fetisova, N. Yu. Vasilyeva, Andrey M. Skripnikov, and Yu. N. Malyar
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technology, industry, and agriculture ,food and beverages ,chemistry.chemical_element ,Infrared spectroscopy ,Diglyme ,macromolecular substances ,General Chemistry ,Nuclear magnetic resonance spectroscopy ,complex mixtures ,Sulfur ,Catalysis ,chemistry.chemical_compound ,Sulfation ,chemistry ,Sulfamic acid ,Organic chemistry ,Lignin - Abstract
Sulfation of wheat straw soda lignin by the sulfamic acid–urea mixture in different solvents has been investigated for the first time. The effect of a catalyst used in the lignin sulfation process on the yield of the lignin sulfates and sulfur content in them has been explored. It has been found that the optimal medium for the lignin sulfation with sulfamic acid is dioxane and, in the presence of a catalyst, urea. Although the sulfated lignins obtained using the reaction in dimethyl sulfoxide and diglyme have the maximum sulfur contents (11.2% and 9.9%, respectively), these products are difficult to isolate and purify, which complicates the use of these solvents. Sulfated lignin obtained in the dioxane medium has a high (10.1%) sulfur content and is easy to isolate and purify. The incorporation of sulfate groups into the lignin structure has been confirmed by the infrared and nuclear magnetic resonance spectroscopy investigations. In the infrared spectra of sulfated lignin, characteristic absorption bands at 800–860 and 1260–1200 cm−1 appear. The dominant substitution of aliphatic hydroxyl groups has been confirmed by the nuclear magnetic resonance spectroscopy study. It has been found that, during the modification and purification of lignin, the latter is fractionated, which results in the redistribution of molecular weights toward the high molecular-weight region, as well as the removal of some low-molecular-weight components, which is reflected in a decrease in the number of signals in the nuclear magnetic resonance spectra.
- Published
- 2022
3. Prevention and prevention of environmental offenses
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N. Yu. Vasilyeva
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- 2021
4. Sulfated Derivatives of Arabinogalactan and Their Anticoagulant Activity
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M. A. Mikhailenko, Svetlana A. Kuznetsova, Yu. N. Malyar, N. N. Drozd, N. Yu. Vasilyeva, Nikolai V. Chesnokov, Boris N. Kuznetsov, and Tatyana P. Shakhtshneider
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0301 basic medicine ,Chromatography ,010405 organic chemistry ,Sodium ,Organic Chemistry ,Dispersity ,Antithrombin ,chemistry.chemical_element ,chemical and pharmacologic phenomena ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,body regions ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,Sulfation ,chemistry ,Arabinogalactan ,parasitic diseases ,medicine ,Sulfamic acid ,Molar mass distribution ,Ammonium ,medicine.drug - Abstract
A comparison of IR spectra and molecular weight distribution of arabinogalactan sulfates as sodium and ammonium salts obtained using various sulfating reagents was performed. According to the data, sulfated derivatives of arabinogalactan differ from each other in the nature of hydrogen bonds and molecular weight distribution. Using coagulological tests during activation of coagulation of platelet-poor human plasma in vitro, the anticoagulant properties of sulfated arabinogalactan derivatives in various salt forms differing in the preparation method, sulfation degree, and molecular weight were studied. It was found that the sample in the form of the sodium salt of sulfated arabinogalactan (SAG 1) with a sulfur content of 13.2 wt % and a polydispersity degree of 1.52 exhibited twofold greater anticoagulant activity than the sample in the form of the ammonium salt of sulfated arabinogalactan (SAG 2) with a sulfur content of 6.6 wt % and a polydispersity degree of 1.30. The antithrombin (aIIa) activity of the samples obtained by sulfation with a complex of pyridine and sulfuric anhydride (SAG 1) and a complex of sulfamic acid (SAG 2) was 23.42 ± 1.86 and 10.20 ± 1.50 U/mg, respectively; the value of the antifactor Xa activity of SAG 1 and SAG 2 was 2.13 ± 0.42 and 0.37 ± 0.08 U/mg; the aIIa/aXa ratio for SAG 1 and SAG 2 was 11 and 28, respectively. The antifactor Xa (aXa) activity of SAG, which is lower than that of unfractionated heparin (UFH), and a high aIIa/aXa activity ratio may contribute to less provocation of bleeding by SAG samples compared to UFH.
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- 2020
5. Synthesis and Properties of Interpolymer Complexes Based on Chitosan and Sulfated Arabinogalactan
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N. V. Slyusarenko, E. A. Slyusareva, M. A. Gerasimova, A. S. Kazachenko, N. Yu. Vasilyeva, and A. S. Romanchenko
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Polymers and Plastics ,Chemistry ,Scanning electron microscope ,Infrared spectroscopy ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Chitosan ,Electrophoresis ,chemistry.chemical_compound ,Sulfation ,Dynamic light scattering ,Arabinogalactan ,Drug delivery ,Polymer chemistry ,Materials Chemistry ,Ceramics and Composites ,0210 nano-technology - Abstract
Interpolymer complexes based on chitosan and arabinogalactan with a different degree of sulfation (7.7–40.8%) stable for 30 days are synthesized. The resulting complexes are characterized by scanning electron microscopy, IR spectroscopy, dynamic light scattering, and ζ-potential electrophoretic measurements. The main mechanism of complex formation is considered in terms of the electrostatic bonding of polyions. New complexes show promise as biosorbents and drug delivery systems.
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- 2020
6. Sulfation of ethanol lignin of abies wood by sulfamic acid in N,N-dimethylformamide medium
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А. V. Levdansky, Boris N. Kuznetsov, V. А. Levdansky, A S Kazachenko, Yu. N. Malyar, N. Yu. Vasilyeva, and Alexander A. Kondrasenko
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Ethanol ,Renewable Energy, Sustainability and the Environment ,020209 energy ,fungi ,technology, industry, and agriculture ,food and beverages ,Alcohol ,macromolecular substances ,02 engineering and technology ,010501 environmental sciences ,complex mixtures ,01 natural sciences ,Gel permeation chromatography ,chemistry.chemical_compound ,Sulfation ,chemistry ,Yield (chemistry) ,0202 electrical engineering, electronic engineering, information engineering ,Sulfamic acid ,Organic chemistry ,Lignin ,Molar mass distribution ,0105 earth and related environmental sciences - Abstract
The sulfation of ethanol lignin of abies wood by sulfamic acid–urea mixture in N,N-dimethylformamide (DMF) medium was studied for the first time. The effect of the duration of lignin sulfation process on the yield and sulfur content in resulted lignin sulfates was studied. It was shown that the reaction of ethanol lignin sulfation begins and ends in a homogeneous medium. At temperature 100 °C, the sulfur content in lignin varies from 5.4 to 6.8% mass, depending on the process time. The introduction of sulfate groups into the lignin structure was confirmed by FTIR and 2D NMR spectroscopy. It was found that both alcohol and phenolic hydroxyl groups of lignin enter the sulfation reaction. The molecular weight distribution of sulfated ethanol lignin was determined by gel permeation chromatography. The optimized method of synthesis allows to obtain sulfated ethanol lignin with low polydispersity (1.31) and narrow molecular weight distribution (3.25–3.75 kDa).
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- 2020
7. Optimization of the process of abies ethanol lignin sulfation by sulfamic acid–urea mixture in 1,4-dioxane medium
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G. P. Skvortsova, Vladimir A. Levdansky, Boris N. Kuznetsov, Alexander A. Kondrasenko, Yu. N. Malyar, Maxim A. Lutoshkin, N. Yu. Vasilyeva, and A. S. Kazachenko
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Ethanol ,fungi ,technology, industry, and agriculture ,food and beverages ,Forestry ,macromolecular substances ,Plant Science ,1,4-Dioxane ,complex mixtures ,Industrial and Manufacturing Engineering ,Gel permeation chromatography ,chemistry.chemical_compound ,Sulfation ,chemistry ,Yield (chemistry) ,Urea ,Sulfamic acid ,Lignin ,General Materials Science ,Nuclear chemistry - Abstract
The new process of abies ethanol lignin sulfation by a low-toxic mixture of sulfamic acid and urea in 1,4-dioxane medium was optimized, and the structure of sulfated ethanol lignin was studied. The process of lignin sulfation is described by a first-order equation in the temperature range 70–100 °C. The value of the rate constants is weakly dependent on the ratios of lignin and sulfating complex (sulfamic acid–urea mixture). The activation energy of the sulfation process decreases from 11.5 to 7.5 kJ/mol with an increase in the content of the sulfating complex (SC). The optimal conditions for sulfation of abies ethanol lignin with a high yield of water-soluble sulfated lignin [(100% of mass) with sulfur content of 7.9%] were found: temperature 95–100 °C, L/SC ratio 1:2.3–1:2.9, time 2 h. The composition and structure of water-soluble sulfated ethanol lignin were determined by elemental analysis, FTIR spectroscopy, two-dimensional NMR spectroscopy and gel permeation chromatography. It was shown that only alcoholic OH groups of ethanol lignin react with sulfamic acid. Sulfated ethanol lignin has a higher molecular weight and a lower degree of polydispersity compared to the initial ethanol lignin.
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- 2020
8. PALEONTOLOGICAL COLLECTION OF THE KYAKHTA LOCAL MUSEUM. WHAT DID WE FORGET ABOUT IT?
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A. E. Murzintseva and N. Yu. Vasilyeva
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General Medicine - Published
- 2020
9. Synthesis and Study of Copper-Containing Polymers of Microcrystalline Cellulose Sulfates from Larch Wood
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Laurent Djakovitch, Boris N. Kuznetsov, N. G. Maximov, Anton Karacharov, N. Yu. Vasilyeva, V. A. Levdansky, A. V. Levdansky, G. P. Skvortsova, Catherine Pinel, IRCELYON-C'Durable (CDURABLE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
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Materials science ,chemistry.chemical_element ,Salt (chemistry) ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Biochemistry ,law.invention ,Crystallinity ,chemistry.chemical_compound ,law ,Fourier transform infrared spectroscopy ,Electron paramagnetic resonance ,chemistry.chemical_classification ,Ion exchange ,Organic Chemistry ,[CHIM.CATA]Chemical Sciences/Catalysis ,021001 nanoscience & nanotechnology ,[SDE.ES]Environmental Sciences/Environmental and Society ,Copper ,0104 chemical sciences ,Microcrystalline cellulose ,chemistry ,Crystallite ,0210 nano-technology ,Nuclear chemistry - Abstract
For the first time, the synthesis of water-soluble copper-containing microcrystalline cellulose sulfates (Сu-MCS) has been performed by the ion exchange method. The composition of the products has been studied by chemical methods and X-ray spectral microanalysis. The copper content in the Сu-MCS samples was 12.6–14.1%. The absence of sodium in the resulting polymer indicates the complete substitution of the sodium cations by the copper cations in the sodium salt of MCC sulfate. The structure of the copper-containing sulfates of microcrystalline cellulose has been confirmed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and electron paramagnetic resonance (EPR). According to the XRD method, Сu-MCS and Na-MCS have an amorphous structure in contrast to the original MCC samples, which have a high degree of crystallinity. The EPR data have demonstrated the formation of a pseudocrystalline structure of the copper-containing salt system in the Сu-MCS samples. As shown by atomic-force microscopy, the surface of the Сu-MCS films consists of homogeneous crystallites, which have a spherical or slightly extended form with the size of about 70 nm. The film surface is quite homogeneous in its phase composition and contains no impurities.
- Published
- 2018
10. Sulfation of arabinogalactan with sulfamic acid under homogeneous conditions in dimethylsulfoxide medium
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Yu. N. Malyar, Boris N. Kuznetsov, A. S. Kazachenko, N. Yu. Vasilyeva, Vladimir A. Levdansky, A. V. Levdansky, and Alexander A. Kondrasenko
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Chemistry ,Original ,Dispersity ,Forestry ,Plant Science ,Industrial and Manufacturing Engineering ,Solvent ,chemistry.chemical_compound ,Sulfation ,Arabinogalactan ,Polymer chemistry ,Side chain ,Sulfamic acid ,Molar mass distribution ,General Materials Science ,Sulfate - Abstract
Sulfation of larch wood arabinogalactan (AG) with sulfamic acid in dimethylsulfoxide (DMSO) medium in the presence of urea was studied for the first time. The use of DMSO as a solvent instead of more toxic 1,4-dioxane allows to sulfate AG under homogeneous conditions. The sulfated AG with a high sulfur content (12.0-12.5 wt %) was produced by sulfation at a temperature of 85-90 °C, the molar ratio of AG / sulfating agent equal to 1:0.85 during 2-3 h. The introduction of sulfate groups into the structure of arabinogalactan was confirmed by the appearance of new absorption bands in FTIR and FT Raman spectra, characteristic for the vibrations of the sulfate groups. It was proved by 13C NMR spectroscopy that the predominant substitution of the primary hydroxyl groups at C6 carbon atoms of the terminal galactose units of main and side chains of arabinogalactan takes place. Simultaneously, the hydroxyl groups associated with C2 and C4 carbon atoms of galactose unit of the main chain are only partially sulfated. According to results of GPC study, the sulfated AG is characterized by a narrow molecular weight distribution with an average molecular weight of 18.8 kDa and a polydispersity of 1.3. Supplementary information The online version contains supplementary material available at 10.1007/s00226-021-01341-2.
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- 2021
11. Synthesis and Study of Copper-Containing Polymers Based on Sulfated Arabinogalactan
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Catherine Pinel, N. G. Maximov, G. P. Skvortsova, Boris N. Kuznetsov, A. V. Levdansky, N. Yu. Vasilyeva, Laurent Djakovitch, A. S. Kazachenko, IRCELYON-C'Durable (CDURABLE), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
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0301 basic medicine ,chemistry.chemical_classification ,Materials science ,Ion exchange ,Organic Chemistry ,Inorganic chemistry ,Infrared spectroscopy ,chemistry.chemical_element ,Salt (chemistry) ,[CHIM.CATA]Chemical Sciences/Catalysis ,[SDE.ES]Environmental Sciences/Environmental and Society ,Biochemistry ,Microanalysis ,Copper ,3. Good health ,law.invention ,03 medical and health sciences ,030104 developmental biology ,chemistry ,law ,Arabinogalactan ,Fourier transform infrared spectroscopy ,Electron paramagnetic resonance - Abstract
Synthesis of water-soluble copper-containing sulfates of arabinogalactan was carried out for the first time by the ion exchange method. Their composition and structure were studied by the methods of elemental and chemical analysis, X-ray spectral microanalysis, atomic force microscopy (AFM), infrared spectroscopy (FTIR), and electron paramagnetic resonance (EPR). According to the AFM data, the surface of copper-containing polymer films does not have inclusions and consists of homogeneous crystallites of a spherical and slightly elongated shape and transverse dimensions of about 100 nm. The composition of copper- containing polymers was studied by the chemical method and X-ray spectral microanalysis. The absence of nitrogen in the obtained polymer indicates the complete replacement of ammonium cations in the ammonium salt of AG sulfate with the copper cations. The IR spectrum of copper-containing AG sulfate is similar to that of the sodium salt of sulfated arabinogalactan. Superposition of two signals was observed in the EPR spectrum of copper-containing AG sulfate. One of them belongs to isolated Cu2+ ions; another, to associated Cu2+ ions in the salt-like compounds. The integral intensity of isolated Cu2+ ion signals (anisotropic signal) and associated ions (isotropic signal) depends on the copper content in the polymer. Water-soluble coppercontaining polymers of AG sulfates have prospects for their use in medicine.
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- 2017
12. The Raman Spectroscopy, XRD, SEM, and AFM Study of Arabinogalactan Sulfates Obtained Using Sulfamic Acid
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Anton Karacharov, Boris N. Kuznetsov, A. V. Levdansky, Elena V. Mazurova, Alexander S. Krylov, G. N. Bondarenko, A. S. Kazachenko, N. Yu. Vasilyeva, and V. A. Levdansky
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Materials science ,Morphology (linguistics) ,010405 organic chemistry ,Scanning electron microscope ,Organic Chemistry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,symbols.namesake ,chemistry.chemical_compound ,Crystallography ,chemistry ,Impurity ,Arabinogalactan ,Surface roughness ,symbols ,Sulfamic acid ,Absorption (chemistry) ,0210 nano-technology ,Raman spectroscopy - Abstract
The structure of sodium salts of arabinogalactan (AG) sulfates obtained by sulfating AG of larch wood with a sulfamic acid–urea mixture in 1,4-dioxane was studied by the methods of Raman spectroscopy, X-ray diffraction (XRD) phase analysis, scanning electron microscopy (SEM), and atomic force microscopy (AFM). The introduction of sulfate groups into the structure of arabinogalactan was confirmed by the appearance in the Raman spectra of new absorption bands related to the deformation vibrations δ (SO3) at 420 cm–1 and δ (О=S=O) at 588 cm–1, stretching vibrations ν (C–O–S) at 822 cm–1, symmetrical stretching vibrations νs (O=S=O) at 1076 cm–1, and asymmetric stretching vibrations of νas (O=S=O) at 1269 cm–1. According to the XRD data, the amorphization of arabinogalactan structure occurs during the sulfation process. The SEM method revealed a significant difference in the morphology of the sulfated and starting arabinogalactan. The starting AG consists of particles of predominantly globular shape with a size of 10 to 90 μm; arabinogalactan sulfates, of particles of various shapes with sizes of 1–8 μm. According to the AFM, the surface of sulfated arabinogalactan film consists of rather homogeneous spherical particles about 70 nm in size. The root-mean-square value of the surface roughness is 33 nm. The surface of sulfated AG film does not contain impurities.
- Published
- 2017
13. Synthesis of the sulfated arabinogalactan tetramethylammonium complex
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A S Kazachenko, Yu. N. Malyar, Angelina V. Miroshnikova, and N. Yu. Vasilyeva
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Tetramethylammonium ,chemistry.chemical_compound ,Sulfation ,chemistry ,Arabinogalactan ,Organic chemistry - Abstract
Sulfated polysaccharides, due to the presence of anionic groups, are able to form complexes with positively charged molecules. This work presents the results of obtaining complexes of the sulfated polysaccharide arabinogalactan with tetramethylammonium bromide. The resulting complex was shown to be soluble in water and methylene chloride. The introduction of tetramethylammonium bromide into the molecule of sulfated arabinogalactan has been proven by elemental analysis and FTIR spectroscopy.
- Published
- 2021
14. Optimization of starch sulfation process with a deep eutectic solvent-mixture of sulfamic acid:urea
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A S Kazachenko, N Yu Vasilyeva, and Yu N Malyar
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History ,chemistry.chemical_compound ,Sulfation ,chemistry ,Chemical engineering ,Starch ,Scientific method ,Sulfamic acid ,Urea ,food and beverages ,Computer Science Applications ,Education ,Deep eutectic solvent - Abstract
The process of sulphation of potato starch with a deep eutectic solvent, a mixture of sulfamic acid: urea, was optimized. The influence of varying factors was established - the ratio of sulfamic acid: urea (SAA: U), the ratio of starch: sulfating complex (St: SC) and the duration of the process on the sulfur content (wt.%) in the obtained starch sulfate. The data of analysis of variance for the obtained mathematical models indicate good prognostic properties. The optimal conditions for starch sulfation, which provide water-soluble sulfated starch with a high (up to 11.2% wt.) sulfur content, have been established. The optimal conditions for the process of sulfation of potato starch are the ratio SAA: U 1: 2.0-1: 2.2, the ratio St: SC 1: 3.5-1: 4.0 and the duration of the process is 118-120 minutes.
- Published
- 2020
15. Synthesis of sulfated starch-casein complex
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A S Kazachenko, N Yu Vasilyeva, Y N Malyar, and E A Slyusareva
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chemistry.chemical_compound ,Sulfation ,Chemistry ,Starch ,Casein ,Microorganism ,chemistry.chemical_element ,Organic chemistry ,Biological activity ,Protonation ,Fourier transform infrared spectroscopy ,Nitrogen - Abstract
In this paper, a new method for the synthesis of the sulfated starch-casein complex is proposed. The resulting new complex was characterized by FTIR and UV-spectroscopy. It has been shown by FTIR spectroscopy that both nitrogen atoms and the carboxyl group of amino acid residues are protonated in casein. The sulfated starch-casein complex obtained in this work may have biological activity, as well as its analogues isolated from plants, fungi, and microorganisms, as well as synthesized in laboratory conditions.
- Published
- 2020
16. Environmentally friendly guar gum sulfation with a sulfamic acid-urea mixture
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N. Yu. Vasilyeva, A S Kazachenko, and Yuriy N. Malyar
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History ,chemistry.chemical_compound ,Guar gum ,Sulfation ,chemistry ,Sulfamic acid ,Urea ,Organic chemistry ,Environmentally friendly ,Computer Science Applications ,Education - Abstract
The guar gum was sulfated for the first time with a deep eutectic solvent, a sulfamic acid / urea mixture at a ratio of (1:1). The optimal conditions of the process are shown to ensure the production of guar gum sulfate with a maximum sulfur content (16.1% wt.). The introduction of a sulfate group into a guar gum molecule is proved by elemental analysis. A mathematical model of the process of sulfation of guar gum is calculated. It is shown that the resulting model has high predictive properties. The developed method is environmentally safer due to the fact that it eliminates the use of toxic solvents.
- Published
- 2020
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