Search

The goal of the “Workshop on Very Cold and Ultra Cold Neutron Sources for ESS” was to discuss scientific cases, ideas and possibilities for the implementation of sources of Very Cold and Ultra Cold neutrons at the European Spallation Source. The ESS facility, presently under construction, offers several possibilities for in-pile UCN or VCN sources, in primis thanks to the available space below the spallation target where additional neutron sources can be placed to complement those above the target. Neutron beams can be extracted over a wide angular range with a grid of forty-two beamports with 6° average angular separation, allowing future instruments to be installed which may view either the upper or lower moderator systems. Of greatest interest for fundamental physics is the so-called Large Beamport foreseen for the NNBAR experiment. This beamport is also particularly well suited to feed a UCN source, for which several ideas were presented that employ either superfluid helium or solid deuterium as established neutron converter materials. Concepts for VCN sources make use of novel materials for VCN production and/or advanced reflectors to increase yields in the coldest part of the neutron spectrum from a cryogenic neutron source. In this paper we discuss these ideas and the possible locations of UCN and VCN sources at ESS.

The NNBAR experiment for the European Spallation Source will search for free neutrons converting to antineutrons with an expected sensitivity improvement of three orders of magnitude compared to the last such search. This paper describes both the simulations of a key component for the experiment, the neutron optical reflector and the expected gains in sensitivity.

Full list of authors: Valtonen, Mauri J.; Dey, Lankeswar; Zola, S.; Ciprini, S.; Kidger, M.; Pursimo, T.; Gopakumar, A.; Matsumoto, K.; Sadakane, K.; Caton, D. B.; Nilsson, K.; Komossa, S.; Bagaglia, M.; Baransky, A.; Boumis, P.; Boyd, D.; Castro-Tirado, A. J.; Debski, B.; Drozdz, M.; Escartin Perez, A.; Fiorucci, M.; Garcia, F.; Gazeas, K.; Ghosh, S.; Godunova, V; Gomez, J. L.; Gredel, R.; Grupe, D.; Haislip, J. B.; Henning, T.; Hurst, G.; Janik, J.; Kouprianov, V. V.; Lehto, H.; Liakos, A.; Mathur, S.; Mugrauer, M.; Naves Nogues, R.; Nucciarelli, G.; Ogloza, W.; Ojha, D. K.; Pajdosz-Smierciak, U.; Pascolini, S.; Poyner, G.; Reichart, D. E.; Rizzi, N.; Roncella, F.; Sahu, D. K.; Sillanpaa, A.; Simon, A.; Siwak, M.; Soldan Alfaro, F. C.; Sonbas, E.; Tosti, G.; Vasylenko, V.; Webb, J. R.; Zielinski, P., OJ 287 is a BL Lacertae type quasar in which the active galactic nucleus (AGN) outshines the host galaxy by an order of magnitude. The only exception to this may be at minimum light when the AGN activity is so low that the host galaxy may make quite a considerable contribution to the photometric intensity of the source. Such a dip or a fade in the intensity of OJ 287 occurred in 2017 November, when its brightness was about 1.75 mag lower than the recent mean level. We compare the observations of this fade with similar fades in OJ 287 observed earlier in 1989, 1999, and 2010. It appears that there is a relatively strong reddening of the B− V colours of OJ 287 when its V-band brightness drops below magnitude 17. Similar changes are also seen in V− R, V− I, and R− I colours during these deep fades. These data support the conclusion that the total magnitude of the host galaxy is V = 18.0 ± 0.3, corresponding to MK = −26.5 ± 0.3 in the K-band. This is in agreement with the results, obtained using the integrated surface brightness method, from recent surface photometry of the host. These results should encourage us to use the colour separation method also in other host galaxies with strongly variable AGN. In the case of OJ 287, both the host galaxy and its central black hole are among the biggest known, and its position in the black hole mass–galaxy mass diagram lies close to the mean correlation. © 2022 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society., SZ would also like to acknowledge support of the NCN grant no. 2018/29/B/ST9/01793, and KM JSPS KAKENHI grant no. 19K03930., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.

Full list of authors: Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A.; Artero, M.; Asano, K.; Babić, A.; Baquero, A.; Barres de Almeida, U.; Barrio, J. A.; Batković, I.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Blanch, O.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Doro, M.; Fallah Ramazani, V.; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Prada Moroni, P. G.; Prandini, E.; Priyadarshi, C.; Puljak, I.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; Baack, D.; Balbo, M.; Biederbeck, N.; Biland, A.; Bretz, T.; Buss, J.; Dorner, D.; Eisenberger, L.; Elsaesser, D.; Hildebrand, D.; Iotov, R.; Mannheim, K.; Neise, D.; Noethe, M.; Paravac, A.; Rhode, W.; Schleicher, B.; Sliusar, V.; Walter, R.; D'Ammando, F.; Horan, D.; Lien, A. Y.; Baloković, M.; Madejski, G. M.; Perri, M.; Verrecchia, F.; Leto, C.; Lähteenmäki, A.; Tornikoski, M.; Ramakrishnan, V.; Järvelä, E.; Vera, R. J. C.; Chamani, W.; Villata, M.; Raiteri, C. M.; Gupta, A. C.; Pandey, A.; Fuentes, A.; Agudo, I.; Casadio, C.; Semkov, E.; Ibryamov, S.; Marchini, A.; Bachev, R.; Strigachev, A.; Ovcharov, E.; Bozhilov, V.; Valcheva, A.; Zaharieva, E.; Damljanovic, G.; Vince, O.; Larionov, V. M.; Borman, G. A.; Grishina, T. S.; Hagen-Thorn, V. A.; Kopatskaya, E. N.; Larionova, E. G.; Larionova, L. V.; Morozova, D. A.; Nikiforova, A. A.; Savchenko, S. S.; Troitskiy, I. S.; Troitskaya, Y. V.; Vasilyev, A. A.; Merkulova, O. A.; Chen, W. P; Samal, M.; Lin, H. C.; Moody, J. W.; Sadun, A. C.; Jorstad, S. G.; Marscher, A. P.; Weaver, Z. R.; Feige, M.; Kania, J.; Kopp, M.; Kunkel, L.; Reinhart, D.; Scherbantin, A.; Schneider, L.; Lorey, C.; Acosta-Pulido, J. A.; Carnerero, M. I.; Carosati, D.; Kurtanidze, S. O.; Kurtanidze, O. M.; Nikolashvili, M. G.; Chigladze, R. A.; Ivanidze, R. Z.; Kimeridze, G. N.; Sigua, L. A.; Joner, M. D.; Spencer, M.; Giroletti, M.; Marchili, N.; Righini, S.; Rizzi, N.; Bonnoli, G.; MAGIC Collaboration; Fact Collaboration.-- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Aims. We present a detailed characterisation and theoretical interpretation of the broadband emission of the paradigmatic TeV blazar Mrk 421, with a special focus on the multi-band flux correlations. Methods. The dataset has been collected through an extensive multi-wavelength campaign organised between 2016 December and 2017 June. The instruments involved are MAGIC, FACT, Fermi-LAT, Swift, GASP-WEBT, OVRO, Medicina, and Metsahovi. Additionally, four deep exposures (several hours long) with simultaneous MAGIC and NuSTAR observations allowed a precise measurement of the falling segments of the two spectral components. Results. The very-high-energy (VHE; E 100 GeV) gamma rays and X-rays are positively correlated at zero time lag, but the strength and characteristics of the correlation change substantially across the various energy bands probed. The VHE versus X-ray fluxes follow dierent patterns, partly due to substantial changes in the Compton dominance for a few days without a simultaneous increase in the X-ray flux (i.e., orphan gamma-ray activity). Studying the broadband spectral energy distribution (SED) during the days including NuSTAR observations, we show that these changes can be explained within a one-zone leptonic model with a blob that increases its size over time. The peak frequency of the synchrotron bump varies by two orders of magnitude throughout the campaign. Our multi-band correlation study also hints at an anti-correlation between UV-optical and X-ray at a significance higher than 3. A VHE flare observed on MJD 57788 (2017 February 4) shows gamma-ray variability on multi-hour timescales, with a factor ten increase in the TeV flux but only a moderate increase in the keV flux. The related broadband SED is better described by a two-zone leptonic scenario rather than by a one-zone scenario.We find that the flare can be produced by the appearance of a compact second blob populated by high energetic electrons spanning a narrow range of Lorentz factors, from 0 min = 2104 to 0 max = 6105. © 2021 Georg Thieme Verlag. All rights reserved., The MAGIC Collaboration would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017-82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588, SEV-2017-0709 and CEX2019-000920-S, and “María de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “María de Maeztu” MDM-2015-0509-18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq and FAPERJ. The important contributions from ETH Zurich grants ETH-10.08-2 and ETH-27.12-1 as well as the funding by the Swiss SNF and the German BMBF (Verbundforschung Astro- und Astroteilchenphysik) and HAP (Helmoltz Alliance for Astroparticle Physics) are gratefully acknowledged. Part of this work is supported by Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center SFB 876 “Providing Information by Resource-Constrained Analysis”, project C3. We are thankful for the very valuable contributions from E. Lorenz, D. Renker and G. Viertel during the early phase of the project. We thank the Instituto de Astrofísica de Canarias for allowing us to operate the telescope at the Observatorio del Roque de los Muchachos in La Palma, the Max-Planck-Institut für Physik for providing us with the mount of the former HEGRA CT3 telescope, and the MAGIC collaboration for their support. The Fermi LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat à l’Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucléaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d’Études Spatiales in France. This work performed in part under DOE Contract DE-AC02-76SF00515. This work made use of data from the NuSTAR mission, a project led by the California Institute of Technology, managed by the Jet Propulsion Laboratory, and funded by the National Aeronautics and Space Administration. We thank the NuSTAR Operations, Software, and Calibration teams for support with the execution and analysis of these observations. This research has made use of the NuSTAR Data Analysis Software (NuSTARDAS) jointly developed by the ASI Science Data Center (ASDC; Italy) and the California Institute of Technology (USA). This research has also made use of the XRT Data Analysis Software (XRTDAS) developed under the responsibility of the ASI Science Data Center (ASDC), Italy. A.A.E and D.P acknowledge support from the Deutsche Forschungs gemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2094 – 390783311. M. B. acknowledges support from the YCAA Prize Postdoctoral Fellowship and from the Black Hole Initiative at Harvard University, which is funded in part by the Gordon and Betty Moore Foundation (grant GBMF8273) and in part by the John Templeton Foundation. This publication makes use of data obtained at the Metsähovi Radio Observatory, operated by Aalto University in Finland. This research has made use of data from the OVRO 40-m monitoring program (Richards et al. 2011) which is supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G and NSF grants AST-0808050 and AST-1109911. I.A. acknowledges financial support from the Spanish “Ministerio de Ciencia e Innovación” (MCINN) through the “Center of Excellence Severo Ochoa” award for the Instituto de Astrofísica de Andalucía-CSIC (SEV-2017-0709). Acquisition and reduction of the MAPCAT data was supported in part by MICINN through grants AYA2016-80889-P and PID2019-107847RB-C44. The MAPCAT observations were carried out at the German-Spanish Calar Alto Observatory, which is jointly operated by Junta de Andalucía and Consejo Superior de Investigaciones Científicas. C.C. acknowledges support from the European Research Council (ERC) under the European Union Horizon 2020 research and innovation program under the grant agreement No 771282. This research was partially supported by the Bulgarian National Science Fund of the Ministry of Education and Science under grants KP-06-H28/3 (2018), KP-06-H38/4 (2019) and KP-06-KITAJ/2 (2020). We acknowledge support by Bulgarian National Science Fund under grant DN18-10/2017 and National RI Roadmap Projects DO1-277/16.12.2019 and DO1-268/16.12.2019 of the Ministry of Education and Science of the Republic of Bulgaria. This research was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract No 451-03-68/2020-14/200002). G.D. acknowledges observing grant support from the Institute of Astronomy and Rozhen NAO BAS through the bilateral joint research project “Gaia Celestial Reference Frame (CRF) and fast variable astronomical objects” (2020–2022, head – G. Damljanovic). The BU group was supported in part by NASA Fermi guest investigator program grants 80NSSC19K1505 and 80NSSC20K1566. This study was based in part on observations conducted using the 1.8 m Perkins Telescope Observatory (PTO) in Arizona, which is owned and operated by Boston University. This article is partly based on observations made with the LCOGT Telescopes, one of whose nodes is located at the Observatorios de Canarias del IAC on the island of Tenerife in the Observatorio del Teide. This article is also based partly on data obtained with the STELLA robotic telescopes in Tenerife, an AIP facility jointly operated by AIP and IAC. The Abastumani team acknowledges financial support by the Shota Rustaveli National Science Foundation under contract FR-19-6174. Based on observations with the Medicina telescope operated by INAF – Istituto di Radioastronomia.

Introduction Laparoscopic liver surgery is spreading, encouraged by technical and technological improvement. Both the obligated narrow space and the difficulty to modify it lead to a more complex approach to the lesions located in the posterosuperior portion of the liver. Surgical strategies such as the Caudal approach or the Diamond technique could ameliorate surgical procedure, but these areas remain a challenge and are still classified as complex. Clinical case We discuss the case of a 68 year old man with metachronous liver metastasis in the dorsal part of segment 8. We used portal phase CT-scan Dicom data to create Three-dimensional reconstruction, which was able to show the more distal branches of intraparenchymal structures. The reconstructed images were subsequently used to plan laparoscopic liver resection. Discussion The capability of three-dimensional reconstruction to create a realistic image allows us to use ultrasound as a navigation tool. Exploiting these two technologies together, we arrived to regulate the resection stages by recognizing previously marked structures and searching them at every intervention phase. The strategy performed demonstrates both a high level of precision and the capability to predict intraparenchymal structures. Conclusion The advantages obtained from three-dimensional reconstruction are numerous in terms of either anatomical comprehension and technical precision, suggesting a potential improvement in surgical skill. Three-dimensional technology should be encouraged and spread to understand, in every single aspect, the potential of its use., Highlights • Laparoscopic liver surgery of the posterosuperior segments remains a complex procedure. • Patient-specific anatomy represents a pivotal point to perform precise and safe resections. • Three-dimensional imaging is the simplest way to know the patient's anatomy, arranging the intraparenchymal structures with high precision. • Three-dimensional technology in all its forms might become a helpful tool in planning and executing surgical interventions.

The violation of baryon number, B , is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the Universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR program is a proposed two-stage experiment at the European Spallation Source to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron–antineutron oscillation ( n → n ̄ ) via mixing, neutron–antineutron oscillation via regeneration from a sterile neutron state ( n → [ n ′ , n ̄ ′ ] → n ̄ ), and neutron disappearance (n → n′); the effective Δ B = 0 process of neutron regeneration ( n → [ n ′ , n ̄ ′ ] → n ) is also possible. The program can be used to discover and characterize mixing in the neutron, antineutron and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis and the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.

Two meteorite pieces have been recovered in Italy, near the town of Cavezzo (Modena), on 2020 January 4th. The associated fireball was observed on the evening of New Year’s Day 2020 by eight all-sky cameras of the PRISMA fireball network, a partner of FRIPON. The computed trajectory had an inclination angle of approximately 68° and a velocity at infinity of 12.8 km s−1. Together with the relatively low terminal height, estimated as 21.5 km, those values were indicating the significant possibility of a meteorite dropping event, as additionally confirmed by the non-zero residual total mass. The strewn-field was computed taking into account the presence of two bright light flashes, revealing that the meteoroid had been very likely subject to fragmentation. Three days after the event, two samples, weighing 3.1 and 52.2 g, were collected as a result of a dedicated field search and thanks to the involvement of the local people. The two pieces were immediately recognized as freshly fallen fragments of meteorite. The computed orbital elements, compared with the ones of known Near-Earth Asteroids from the NEODyS database, are compatible with one asteroid only; 2013 VC10. The estimated original mass of the meteoroid, 3.5 kg, and size, approximately 13 cm, is so far the smallest among the current 35 cases in which meteorites were recovered from precise strewn-field computation thanks to observational data. This result demonstrates the effectiveness of accurate processing of fireball network data even on challenging events generated by small size meteoroids.

Full list of authors: Raiteri, C. M.; Villata, M.; Carosati, D.; Benítez, E.; Kurtanidze, S. O.; Gupta, A. C.; Mirzaqulov, D. O.; D'Ammando, F.; Larionov, V. M.; Pursimo, T.; Acosta-Pulido, J. A.; Baida, G. V.; Balmaverde, B.; Bonnoli, G.; Borman, G. A.; Carnerero, M. I.; Chen, W. -P.; Dhiman, V.; Di Maggio, A.; Ehgamberdiev, S. A.; Hiriart, D.; Kimeridze, G. N.; Kurtanidze, O. M.; Lin, C. S.; Lopez, J. M.; Marchini, A.; Matsumoto, K.; Mujica, R.; Nakamura, M.; Nikiforova, A. A.; Nikolashvili, M. G.; Okhmat, D. N.; Otero-Santos, J.; Rizzi, N.; Sakamoto, T.; Semkov, E.; Sigua, L. A.; Stiaccini, L.; Troitsky, I. S.; Tsai, A. L.; Vasilyev, A. A.; Zhovtan, A. V., Blazar S5 0716+714 is well-known for its short-term variability, down to intraday time-scales. We here present the 2-min cadence optical light curve obtained by the TESS space telescope in 2019 December-2020 January and analyse the object fast variability with unprecedented sampling. Supporting observations by the Whole Earth Blazar Telescope Collaboration in B, V, R, and I bands allow us to investigate the spectral variability during the TESS pointing. The spectral analysis is further extended in frequency to the UV and X-ray bands with data from the Neil Gehrels Swift Observatory. We develop a new method to unveil the shortest optical variability time-scales. This is based on progressive de-trending of the TESS light curve by means of cubic spline interpolations through the binned fluxes, with decreasing time bins. The de-trended light curves are then analysed with classical tools for time-series analysis (periodogram, autocorrelation, and structure functions). The results show that below 3 d there are significant characteristic variability time-scales of about 1.7, 0.5, and 0.2 d. Variability on time-scales $\lesssim 0.2$ d is strongly chromatic and must be ascribed to intrinsic energetic processes involving emitting regions, likely jet substructures, with dimension less than about 10-3 pc. In contrast, flux changes on time-scales $\gtrsim 0.5$ d are quasi-achromatic and are probably due to Doppler factor changes of geometric origin. © 2020 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society, The Astronomical Observatory of the University of Siena thanks the friend amateur astronomers Massimo Conti and Claudio Vallerani for their invaluable and unceasing contribution, essential for the performance of the observatory. This paper includes data collected by the TESS mission. Funding for the TESS mission is provided by the NASA Explorer Program. This research has made use of NASA's Astrophysics Data System and of the NASA/IPAC Extragalactic Database (NED), which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. Based on observations made with the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. Based (partly) on data obtained with the STELLA robotic telescopes in Tenerife, an AIP facility jointly operated by AIP and IAC. This work is partly based upon observations carried out at the Observatorio Astronomico Nacional on the Sierra San Pedro Martir (OAN-SPM), Baja California, Mexico. This research was partially supported by the Bulgarian National Science Fund of the Ministry of Education and Science under grantsDN18-13/2017, KP06-H28/3, and KP-06-PN38/4. KM acknowledges JSPS KAKENHI grant no. JP19K03930. SOK acknowledges financial support by Shota Rustaveli National Science Foundation of Georgia under contract PHDF-18-354. EB acknowledges support from DGAPAPAPIIT GRANT IN113320. GB acknowledges financial support from the State Agency for Research of the Spanish MCIU through the 'Center of Excellence Severo Ochoa' award to the Instituto de Astrofisica de Andalucia (SEV-2017-0709).

In an effort to locate the sites of emission at different frequencies and physical processes causing variability in blazar jets, we have obtained high time-resolution observations of BL Lacertae over a wide wavelength range: with the Transiting Exoplanet Survey Satellite (TESS) at 6000–10000 Å with 2 minute cadence; with the Neil Gehrels Swift satellite at optical, UV, and X-ray bands; with the Nuclear Spectroscopic Telescope Array at hard X-ray bands; with the Fermi Large Area Telescope at γ-ray energies; and with the Whole Earth Blazar Telescope for measurement of the optical flux density and polarization. All light curves are correlated, with similar structure on timescales from hours to days. The shortest timescale of variability at optical frequencies observed with TESS is ∼0.5 hr. The most common timescale is 13 ± 1 hr, comparable with the minimum timescale of X-ray variability, 14.5 hr. The multiwavelength variability properties cannot be explained by a change solely in the Doppler factor of the emitting plasma. The polarization behavior implies that there are both ordered and turbulent components to the magnetic field in the jet. Correlation analysis indicates that the X-ray variations lag behind the γ-ray and optical light curves by up to ∼0.4 day. The timescales of variability, cross-frequency lags, and polarization properties can be explained by turbulent plasma that is energized by a shock in the jet and subsequently loses energy to synchrotron and inverse Compton radiation in a magnetic field of strength ∼3 G.

The object 4C 71.07 is a high-redshift blazar whose spectral energy distribution shows a prominent big blue bump and a strong Compton dominance. We present the results of a 2- yr multiwavelength campaign led by the Whole Earth Blazar Telescope (WEBT) to study both the quasar core and the beamed jet of this source. The WEBT data are complemented by ultraviolet and X-ray data from Swift, and by γ-ray data by Fermi. The big blue bump is modelled by using optical and near-infrared mean spectra obtained during the campaign, together with optical and ultraviolet quasar templates. We give prescriptions to correct the source photometry in the various bands for the thermal contribution, in order to derive the non-thermal jet flux. The role of the intergalactic medium absorption is analysed in both the ultraviolet and X-ray bands.We provide opacity values to deabsorb ultraviolet data, and derive a best-guess value for the hydrogen column density of Nbest H = 6.3 × 10 cmthrough the analysis of X-ray spectra.We estimate the disc and jet bolometric luminosities, accretion rate, and black hole mass. Light curves do not show persistent correlations among flux changes at different frequencies. We study the polarimetric behaviour and find no correlation between polarization degree and flux, even when correcting for the dilution effect of the big blue bump. Similarly, wide rotations of the electric vector polarization angle do not seem to be connected with the source activity.© 2019 The Author(s)., We acknowledge financial contribution from the agreement ASI-INAF n.2017-14-H.0 and from the contract PRIN-SKA-CTA-INAF 2016. PR and SV acknowledge contract ASI-INAF I/004/11/0. We acknowledge support by Bulgarian National Science Programme 'Young Scientists and Postdoctoral Students 2019', Bulgarian National Science Fund under grant DN18-10/2017 and National RI Roadmap Projects DO1-157/28.08.2018 and DO1-153/28.08.2018 of the Ministry of Education and Science of the Republic of Bulgaria. GD and OV gratefully acknowledge the observing grant support from the Institute of Astronomy and Rozhen National Astronomical Observatory, Bulgarian Academy of Sciences via bilateral joint research project 'Study of ICRF radio-sources and fast variable astronomical objects' (head -G.Damljanovic). This work is a part of the Projects No. 176011 ('Dynamics and Kinematics of Celestial Bodies and Systems'), No. 176004 ('Stellar Physics'), and No. 176021 ('Visible and Invisible Matter in Nearby Galaxies: Theory and Observations') supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia. This research was partially supported by the Bulgarian National Science Fund of theMinistry of Education and Science under grants DN 08-1/2016, DN 18-13/2017, and KP-06-H28/3 (2018). The Skinakas Observatory is a collaborative project of the University of Crete, the Foundation for Research and Technology -Hellas, and the Max-Planck-Institut fur Extraterrestrische Physik. The St Petersburg University team acknowledges support from Russian Science Foundation grant no. 17-12-01029. The Abastumani team acknowledges financial support by the Shota Rustaveli National Science Foundation under contract FR/217950/16. This work was partly supported by the National Science Fund of the Ministry of Education and Science of Bulgaria under grant DN 08-20/2016, and by funds of the project RD-08-37/2019 of the University of Shumen. The Astronomical Observatory of the Autonomous Region of the Aosta Valley (OAVdA) is managed by the Fondazione Clement Fillietroz-ONLUS, which is supported by the Regional Government of the Aosta Valley, the Town Municipality of Nus and the Unite des Communes valdotaines Mont-Emilius'. The research at the OAVdA was partially funded by two 'Research and Education' grants from Fondazione CRT

We report on long-term multiwavelength monitoring of blazar Mrk 421 by the GLAST-AGILE Support Program of the Whole Earth Blazar Telescope (GASP-WEBT) collaboration and Steward Observatory, and by the Swift and Fermi satellites. We study the source behaviour in the period 2007-2015, characterized by several extreme flares. The ratio between the optical, X-ray and γ-ray fluxes is very variable. The γ-ray flux variations show a fair correlation with the optical ones starting from 2012. We analyse spectropolarimetric data and find wavelength-dependence of the polarization degree (P), which is compatible with the presence of the host galaxy, and no wavelength dependence of the electric vector polarization angle (EVPA). Optical polarimetry shows a lack of simple correlation between P and flux and wide rotations of the EVPA. We build broad-band spectral energy distributions with simultaneous near-infrared and optical data from the GASP-WEBT and ultraviolet and X-ray data from the Swift satellite. They show strong variability in both flux and X-ray spectral shape and suggest a shift of the synchrotron peak up to a factor of ~50 in frequency. The interpretation of the flux and spectral variability is compatible with jet models including at least two emitting regions that can change their orientation with respect to the line of sight.© 2017 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society., The Abastumani team acknowledges financial support by Shota Rustaveli NSF under contract FR/577/6-320/13. The research at BU was supported in part by US National Science Foundation grant AST-1615796 and NASA Fermi Guest Investigator grant NNX14AQ58G. This study makes use of 43 GHz VLBA data from the VLBA-BU Blazar Monitoring Program (VLBA-BUBLAZAR; http://www.bu.edu/blazars/VLBAproject.html), funded by NASA through the Fermi Guest Investigator Program. The PRISM camera at the Lowell Observatory was developed by K. Janes et al. at the BU and Lowell Observatory, with funding from the NSF, BU and Lowell Observatory. This research has made use of data from the MOJAVE data base, which is maintained by the MOJAVE team (Lister et al. 2009). The St. Petersburg University team acknowledges support from Russian RFBR grant 15-02-00949 and St. Petersburg University research grant 6.38.335.2015. This paper is partly based on observations carried out at the German Spanish Calar Alto Observatory, which is jointly operated by the MPIA and the IAA-CSIC. IA research is supported by a Ramon y Cajal grant of the Spanish Ministerio de Economia y Competitividad (MINECO). Acquisition of the MAPCAT data was supported in part by MINECO through grants AYA2010-14844, AYA2013-40825-P and AYA2016-80889-P, and by the Regional Government of Andalucia through grant P09-FQM-4784. This research was partially supported by the Scientific Research Fund of the Bulgarian Ministry of Education and Sciences under grants DO 02-137 (BIn-13/09) and DN 08/1. The Skinakas Observatory is a collaborative project of the University of Crete, the Foundation for Research and Technology - Hellas and the Max-Planck-Institut fur Extrater-restrische Physik. GD and OV gratefully acknowledge the observing grant support from the Institute of Astronomy and Rozhen National Astronomical Observatory, Bulgaria Academy of Sciences, via the bilateral joint research project 'Observations of ICRF radio-sources visible in optical domain' (the head is Dr G. Damljanovic). This work is a part of the Projects No 176011 ('Dynamics and kinematics of celestial bodies and systems'), No 176004 ('Stellar physics') and No 176021 ('Visible and invisible matter in nearby galaxies: theory and observations') supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia. The Serbian station is the Astronomical Station Vidojevica (ASV) with the 60-cm ASV telescope (and from this year, the 1.4-m ASV one). This research was supported partly by funds of the project RD-08-81 of the Shumen University.

We present a multiwavelength study of the flat-spectrum radio quasar CTA 102 during 2013-2017. We use radio-to-optical data obtained by the Whole Earth Blazar Telescope, 15 GHz data from the Owens Valley Radio Observatory, 91 and 103 GHz data from the Atacama Large Millimeter Array, near-infrared data from the Rapid Eye Monitor telescope, as well as data from the Swift (optical-UV and X-rays) and Fermi (γ -rays) satellites to study flux and spectral variability and the correlation between flux changes at different wavelengths. Unprecedented γ -ray flaring activity was observed during 2016 November-2017 February, with four major outbursts. A peak flux of (2158 ± 63) × 10−8 ph cm−2 s−1, corresponding to a luminosity of (2.2 ± 0.1) × 1050 erg s−1, was reached on 2016 December 28. These four γ -ray outbursts have corresponding events in the near-infrared, optical, and UV bands, with the peaks observed at the same time. A general agreement between X-ray and γ -ray activity is found. The γ -ray flux variations show a general, strong correlation with the optical ones with no time lag between the two bands and a comparable variability amplitude. This γ -ray/optical relationship is in agreement with the geometrical model that has successfully explained the low-energy flux and spectral behaviour, suggesting that the long-term flux variations are mainly due to changes in the Doppler factor produced by variations of the viewing angle of the emitting regions. The difference in behaviour between radio and higher energy emission would be ascribed to different viewing angles of the jet regions producing their emission. © 2019 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society, The data collected by the WEBT collaboration are stored in the WEBT archive at the Osservatorio Astrofisico di Torino INAF (http://www.oato.inaf.it/blazars/webt/); for questions regarding their availability, contact the WEBT President Massimo Villata(massimo.villata@inaf.it).We acknowledge financial contribution from the agreementASI-INAFn. 2017-14-H.0 and from the contract PRIN-SKA-CTA-INAF 2016. This research was partially supported by the Bulgarian National Science Fund of the Ministry of Education and Science under grants DN 08-1/2016, DN 18-13/2017, and KP-06-H28/3 (2018). The Skinakas Observatory is a collaborative project of the University of Crete, the Foundation for Research and Technology -Hellas, and the Max-Planck-Institut fur Extraterrestrische Physik. The Abastumani team acknowledges financial support by the Shota Rustaveli National Science Foundation under contract FR/217554/16. The St. Petersburg University team acknowledges support from Russian Science Foundation grant 17-12-01029. GD and OV gratefully acknowledge the observing grant support from the Institute of Astronomy and Rozhen National Astronomical Observatory, Bulgarian Academy of Sciences, via bilateral joint research project 'Study of ICRF radio-sources and fast variable astronomical objects' (head -G.Damljanovic). This work is a part of the Projects No. 176011 ('Dynamics and Kinematics of Celestial Bodies and Systems'), No. 176004 ('Stellar Physics'), and No. 176021 ('Visible and Invisible Matter in Nearby Galaxies: Theory and Observations') supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia. JE is indebted to DGAPA (Universidad Nacional Autonoma de M ' exico) for financial support, PAPIIT project IN114917. The Submillimeter Array is a joint project between the Smithsonian Astrophysical Observatory and the Academia Sinica Institute of Astronomy and Astrophysics and is funded by the Smithsonian Institution and the Academia Sinica. Data from the Steward Observatory blazar monitoring project were used. This program is supported by NASA/Fermi Guest Investigator grants NNX12AO93G and NNX15AU81G. We acknowledge support by Bulgarian National Science Programme 'Young Scientists and Postdoctoral Students 2019', Bulgarian National Science Fund under grant DN18-10/2017 and National RI Roadmap Projects DO1-157/28.08.2018 and DO1-153/28.08.2018 of the Ministry of Education and Science of the Republic of Bulgaria. This publication makes use of data obtained at Mets ahovi Radio Observatory, operated by Aalto University in Finland. The Astronomical Observatory of the Autonomous Region of theAostaValley (OAVdA) is managed by the Fondazione Clment Fillietroz-ONLUS, which is supported by the Regional Government of the Aosta Valley, the TownMunicipality of Nus and the 'Unit des Communes valdtaines Mont-milius'. The research at the OAVdA was partially funded by two 'Research and Education' grants from Fondazione CRT. RR acknowledges support from CONICYT project Basal AFB-170002. MM and TM acknowledge support through the Russian Government Program of Competitive Growth of Kazan Federal University. The Fermi LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat a l'Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucleaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d'Etudes Spatiales in France. This work performed in part under DOE Contract DE-AC02-76SF00515. The OVRO 40-m monitoring program is supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G, and NSF grants AST-0808050 and AST-1109911. We thank the Swift team for making these observations possible, the duty scientists, and science planners. This research has made use of the NASA/IPAC Extragalactic Database (NED) which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration. FD thanks S. Covino for his help with the REM data reduction. This research has made use of data obtained from the high-energy Astrophysics Science Archive Research Center (HEASARC) provided by NASA's Goddard Space Flight Center.

Blazar emission is dominated by non-thermal radiation from a relativistic jet pointing toward us, therefore undergoing Doppler beaming. This is responsible for flux enhancement and contraction of the variability time scales, so that most blazars appear as luminous sources characterized by noticeable and fast flux changes at all frequencies. The mechanisms producing their unpredictable variability are debated and include injection, acceleration and cooling of particles, with possible intervention of shock waves or turbulence. Changes in the viewing angle of the emitting knots or jet regions have also been suggested to explain flaring events or specific properties such as intraday variability, quasi-periodicities, or the delay of radio flux variations relative to optical changes. However, such a geometric interpretation has not been universally accepted because alternative explanations based on changes of physical conditions can also work in many cases. Here we report the results of optical-to-radio monitoring of the blazar CTA 102 by the Whole Earth Blazar Telescope Collaboration and show that the observed long-term flux and spectral variability is best explained by an inhomogeneous, curved jet that undergoes orientation changes. We propose that magnetohydrodynamic instabilities or rotation of a twisted jet cause different jet regions to change their orientation and hence their relative Doppler factors. In particular, the recent extreme optical outburst (six magnitudes) occurred when the corresponding jet emitting region acquired a minimum viewing angle., Comment: 31 pages, 11 figures. This is the accepted version (before Nature editing) of the paper published by Nature, online version at http://dx.doi.org/10.1038/nature24623, Nature 2017/12/04/online

In 2015 July 29 - September 1 the satellite XMM-Newton pointed at the BL Lac object PG 1553+133 six times, collecting data for 218 hours. During one of these epochs, simultaneous observations by the Swift satellite were requested to compare the results of the X-ray and optical-UV instruments. Optical, near-infrared and radio monitoring was carried out by the Whole Earth Blazar Telescope (WEBT) collaboration for the whole observing season. We here present the results of the analysis of all these data, together with an investigation of the source photometric and polarimetric behaviour over the last three years. The 2015 EPIC spectra show slight curvature and the corresponding light curves display fast X-ray variability with a time scale of the order of 1 hour. In contrast to previous results, during the brightest X-ray states detected in 2015 the simple log-parabolic model that best-fits the XMM-Newton data also reproduces reasonably well the whole synchrotron bump, suggesting a peak in the near-UV band. We found evidence of a wide rotation of the polarization angle in 2014, when the polarization degree was variable, but the flux remained almost constant. This is difficult to interpret with deterministic jet emission models, while it can be easily reproduced by assuming some turbulence of the magnetic field., Comment: 15 pages, 12 figures, accepted by Monthly Notices of the Royal Astronomical Society

High-resolution chromosome banding and chromosomal in situ suppression hybridization were used to identify a derivative X in a 10-month-old female patient with congenital heart defect and slight dysmorphism. The unbalanced karyotype was monosomic for Xp22.3-pter and trisomic for 3p23 -pter regions. The derivative X was inherited from the mother carrier of a balanced translocation (X;3) (p22.3;p23). Replication study of the patient showed the abnormal X,t(X;3) to be late replicating, except for the translocated segment. This patient demonstrated only epicanthus and congenital heart defect, despite her partial trisomy 3. The clinical phenotype may be less severe when the X-chromosome is involved in an unbalanced translocation.

Here we report on the results of the WEBT photo-polarimetric campaign targeting the blazar S5~0716+71, organized in March 2014 to monitor the source simultaneously in BVRI and near IR filters. The campaign resulted in an unprecedented dataset spanning $\sim 110$\,h of nearly continuous, multi-band observations, including two sets of densely sampled polarimetric data mainly in R filter. During the campaign, the source displayed pronounced variability with peak-to-peak variations of about $30\%$ and "bluer-when-brighter" spectral evolution, consisting of a day-timescale modulation with superimposed hourlong microflares characterized by $\sim 0.1$\,mag flux changes. We performed an in-depth search for quasi-periodicities in the source light curve; hints for the presence of oscillations on timescales of $\sim 3$\,h and $\sim 5$\,h do not represent highly significant departures from a pure red-noise power spectrum. We observed that, at a certain configuration of the optical polarization angle relative to the positional angle of the innermost radio jet in the source, changes in the polarization degree led the total flux variability by about 2\,h; meanwhile, when the relative configuration of the polarization and jet angles altered, no such lag could be noted. The microflaring events, when analyzed as separate pulse emission components, were found to be characterized by a very high polarization degree ($> 30\%$) and polarization angles which differed substantially from the polarization angle of the underlying background component, or from the radio jet positional angle. We discuss the results in the general context of blazar emission and energy dissipation models., 16 pages, 17 Figures; ApJ accepted

An interlaboratory study was conducted to evaluate the effectiveness of an immunoaffinity column cleanup liquid chromatography (LC) method for the determination of aflatoxin B1 levels in corn samples, enforced by European Union legislation. A test portion was extracted with methanolwater (80 + 20); the extract was filtered, diluted with phosphate-buffered saline solution, filtered on a microfiber glass filter, and applied to an immunoaffinity column. The column was washed with deionized water to remove interfering compounds, and the purified aflatoxin B1 was eluted with methanol. Aflatoxin B1 was separated and determined by reversed-phase LC with fluorescence detection after either pre- or postcolumn derivatization. Precolumn derivatization was achieved by generating the trifluoroacetic acid derivative, used by 8 laboratories. The postcolumn derivatization was achieved either with pyridinium hydrobromide perbromide, used by 16 laboratories, or with an electrochemical cell by the addition of bromide to the mobile phase, used by 5 laboratories. The derivatization techniques used were not significantly different when compared by the Student's t-test; the method was statistically evaluated for all the laboratories. Five corn sample materials, both spiked and naturally contaminated, were sent to 29 laboratories (22 Italian and 7 European). Test portions were spiked with aflatoxin B1 at levels of 2.00 and 5.00 ng/g. The mean values for recovery were 82% for the low level and 84% for the high contamination level. Based on results for spiked samples (blind pairs at 2 levels) as well as naturally contaminated samples (blind pairs at 3 levels), the values for relative standard deviation for repeatability (RSDr) ranged from 9.9 to 28.7%. The values for relative standard deviation for reproducibility (RSDR) ranged from 18.6 to 36.8%. The method demonstrated acceptable within- and between-laboratory precision for this matrix, as evidenced by the HorRat values.

The occurrence of low-amplitude flux variations in blazars on hourly timescales, commonly known as microvariability, is still a widely debated subject in high-energy astrophysics. Several competing scenarios have been proposed to explain such occurrences, including various jet plasma instabilities leading to the formation of shocks, magnetic reconnection sites, and turbulence. In this letter we present the results of our detailed investigation of a prominent, five-hour-long optical microflare detected during recent WEBT campaign in 2014, March 2-6 targeting the blazar 0716+714. After separating the flaring component from the underlying base emission continuum of the blazar, we find that the microflare is highly polarized, with the polarization degree $\sim (40-60)\%$$\pm (2-10)\%$, and the electric vector position angle $\sim (10 - 20)$deg$\pm (1-8)$deg slightly misaligned with respect to the position angle of the radio jet. The microflare evolution in the $(Q,\,U)$ Stokes parameter space exhibits a looping behavior with a counter-clockwise rotation, meaning polarization degree decreasing with the flux (but higher in the flux decaying phase), and approximately stable polarization angle. The overall very high polarization degree of the flare, its symmetric flux rise and decay profiles, and also its structured evolution in the $Q-U$ plane, all imply that the observed flux variation corresponds to a single emission region characterized by a highly ordered magnetic field. As discussed in the paper, a small-scale but strong shock propagating within the outflow, and compressing a disordered magnetic field component, provides a natural, though not unique, interpretation of our findings., Comment: 9 pages, 4 Figures, ApJ Letter accepted

We present the most continuous data base of optical multiband data ever published on the BL Lacertae object ON 231 (W Com). The data have been collected during an intensive and coordinated BVRcIc monitoring campaign carried out in the period from March 1994 to March 1997. During our campaign, the source brightness was at the highest level ever observed. The light curve shows a complex structure, characterized by the pres- ence of three major outbursts having the observed max- ima in March 1995, February 1996, and January 1997, when ON 231 reached its historical maximum (B' 14:2). Variability on time scales from a few hours up to a month have frequently been observed and the light curve seems to be the superposition of many flares with dierent ampli- tudes and time scales. The broad-band optical spectral en- ergy distribution is characterized by a spectral slope which correlates with the flux level. In particular, the higher is the flux the flatter is the spectrum.

A small supernumerary chromosome was observed in two Prader-Willi syndrome (PWS) patients. The clinical diagnosis of PWS was confirmed by the ascertainment of the deletion of region 15q11-13 in one case and uniparental disomy (UPD) of the same region in the other. The markers were negative for dystamycinA/DAPI banding, did not contain NOR-positive satellites, and had an appearance consistent with a very small ring chromosome. Fluorescent in situ hybridization (FISH) analysis with the “all human centromere” probe indicated the presence of centromeric sequences in both markers. Chromosomal in situ suppression hybridization with chromosome specific libraries demonstrated that the small markers in the deleted and UPD patient originated from chromosome 15 and X, respectively. To the best of our knowledge these are the only PWS patients reported with a supernumerary marker chromosome other than inv dup(15) characterized by FISH. Am. J. Med. Genet. 68:99–104, 1997 © 1997 Wiley-Liss, Inc.

In this paper we report about the biodegradation of tri-block poly (ester-ether-ester) copolymers obtained by reaction of preformed poly (ethylene glycol) (PEG) with two different lactone monomers, i.e. e-caprolactone (CL) and L-lactide (LA). The two series of copolymers will be indicated as PCL-POE-PCL and PLA-POE-PLA. We identified and measured by HPLC analysis the amount of degradation products of the poly (ester-ether-ester) copolymers; three copolymers were tested for each series during 3–8 week experiments. The experiments were carried out both in the presence and absence of fibroblast cell populations. We evaluated at the same time the decrease of copolymer molecular mass after degradation by means of intrinsic viscosity [η] measurements. From the [η] measurements we can conclude that the higher the hydrophilicity of the material, the faster the rate of decrease of its intrinsic viscosity with time. The HPLC results indicate that the amount of the degradation products, i.e., respectively, the monomers 6-hydroxyhexanoic acid and L-lactic acid, is a function of both hydrophilicity of the molecule and the lateral block length. When the fibroblast cell populations were present in the same wells together with the biodegradable copolymers, signs of cellular metabolism of the degraded monomers were detected.

Two guest‐observer XMM‐Newton observations of the peculiar blazar OJ 287 in 2005 are briefly presented, along with the multiwavelength data obtained during a coordinated intensive WEBT campaign, and data obtained within longer‐term independent monitor programs, performed also by other facilities. During that year OJ 287 showed an interesting variability trend in the optical band. The X‐ray observations, performed in correspondence with two active optical states (a flare and an outburst), indicate different flux levels, spectral slopes, and emission components, while VLBA radio maps are consistent with a jet precession model. A further XMM‐Newton observation of OJ 287 is granted and foreseen in spring 2008, providing the opportunity of a multifrequency campaign to be performed in conjunction with GLAST.

We have investigated the production of the BSCCO 2223 phase by using four different types of starting chemical compounds with the same thermal treatment. Samples have been characterised in various aspects, and the 2223 phase volume fractions have been accurately determined by applying the effective medium theory to magnetic susceptibility measurements. The results show that polycrystalline samples are well described by the spherical inclusion granular model, and that organic precursors strongly inhibit the production of the 2223 phase with respect to inorganic ones.

A small supernumerary chromosome was observed in two Prader-Willi syndrome (PWS) patients. The clinical diagnosis of PWS was confirmed by the ascertainment of the deletion of region 15q11-13 in one case and uniparental disomy (UPD) of the same region in the other. The markers were negative for dystamycinA/DAPI banding, did not contain NOR-positive satellites, and had an appearance consistent with a very small ring chromosome. Fluorescent in situ hybridization (FISH) analysis with the "all human centromere" probe indicated the presence of centromeric sequences in both markers. Chromosomal in situ suppression hybridization with chromosome specific libraries demonstrated that the small markers in the deleted and UPD patient originated from chromosome 15 and X, respectively. To the best of our knowledge these are the only PWS patients reported with a supernumerary marker chromosome other than inv dup(15) characterized by FISH.

Metal Organic Deposition (MOD) technique, which represents a flexible method for obtaining both platelets and films of YBCO, is based on baking, pyrolyzing and annealing stages of neodecanoates solutions. The annealing step is generally very long. The whole annealing stage can be simply substituted by a heat treatment (about 1 h) in a commercial microwave (MW) oven, followed by a 15 min. annealing at 900°C in a resistive furnace without oxygenation. With this process, YBCO platelets, films and wires were obtained starting from powders prepared by MO (Metal-Oxide). XRD patterns are indicative of a strong texturing by the evidence of (003) and (005) lines. By the same technique, YBCO films were prepared by spray deposition on A12O 3 for a total thickness of about 5 μm, each spray step, of 1 gm, was followed by 5 min pyrolysis at 500 °C and 1 h MW annealing.The MW technique was also used for preparation of quartz and ceramic fibers covered by YBCO.

We report on a combined high resolution cytogenetic and fluorescent in situ hybridization study (FISH) on 15 Prader-Willi syndrome (PWS) and 14 Angelman syndrome (AS) patients. High resolution banding showed a microdeletion in the 15q11-q13 region in 7 out of 15 PWS patients, and FISH analysis of the D15S11 and SNRPN cosmids demonstrated absence of the critical region in three additional cases. Likewise 8 out of 14 AS patients were found to be deleted with FISH, using the GABRB3 specific cosmid, whereas only 4 of them had a cytogenetically detectable deletion.

Paracentric inversions have been described less frequently than pericentric ones. It is not known whether this is due to their rarity or rather to difficulty in detecting intra-arm rearrangements. Paracentric inversions have been noted in all chromosomes except chromosome 19; the short arm was involved in 21 cases and the long arm in 87. We describe the first case of paracentric inversion in chromosome 19. The patient, a 29-year-old man, was referred for cytogenetic investigation because his wife had had 3 spontaneous abortions. No history of subfertility was recorded. Chromosome studies on peripheral blood lymphocytes demonstrated an abnormal QFQ banding pattern in the short arm of one chromosome 19. The comparison between QFQ, GTG and RBA banding led us to suspect a paracentric inversion involving the chromosome 19 short arm. CBG banding resulted in an apparently normal position of the centromere. Parental chromosome studies showed the same anomaly in the patient`s mother. 4 refs.

1. An analysis of 500 cases of incomplete abortion is presented. 2. The method of management at The Queens Hospital Center is discussed. 3. We feel that our results indicate that the routine use of oxytocin infusion and the almost general employment of curettage reduces the total hospital stay, blood loss, morbidity, and convalescence time. 4. The administration of specific therapeutic antibiotics in adequate doses should be instituted without hesitation. 5. The administration of prophylactic antibiotics is strongly questioned.