1. Microbes and Infection
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Oliveira, Fabiano, Melo Junior, José F., Fidelis, Ramon, N. Neto, Antônio, Barral-Netto, Manoel, Barbosa Júnior, Aryon de Almeida, Barbosa, Theolis, Arruda, Sérgio Marcos, and Chalhoub, Marcelo
- Subjects
Disease progression ,Pathology ,Tuberculosis ,Cytokines ,Pleural - Abstract
Texto completo: acesso restrito. p.889–897 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-28T14:57:12Z No. of bitstreams: 1 1-s2.0-S1286457905003850-main.pdf: 384972 bytes, checksum: 27e908da6c9d12feb43c5c98c08f8492 (MD5) Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T17:48:27Z (GMT) No. of bitstreams: 1 1-s2.0-S1286457905003850-main.pdf: 384972 bytes, checksum: 27e908da6c9d12feb43c5c98c08f8492 (MD5) Made available in DSpace on 2013-10-31T17:48:27Z (GMT). No. of bitstreams: 1 1-s2.0-S1286457905003850-main.pdf: 384972 bytes, checksum: 27e908da6c9d12feb43c5c98c08f8492 (MD5) Previous issue date: 2006 In order to identify mediators involved in immune-mediated disease regression, the pleural cytokine and histopathological profile was evaluated in tuberculous pleurisy patients with varied disease duration and clinical presentation, previous to chemotherapy. Interleukin (IL)-10, interferon (IFN)-γ and tumor necrosis factor (TNF) levels in pleural fluids were shown to decrease with disease time. IL-10 was positively correlated with IFN-γ, TNF and necrosis area in pleural sections. To parallel these findings with disease regression, individuals showing fever, anorexia, and progressive exudate in the pleural cavity (active disease) were compared with patients without symptoms and with a decrease in exudate volume (regressive disease). IFN-γ and TNF levels were lower in regressive disease, as well as reduced necrosis area in pleural sections. Our results indicate that tissue destruction and a prominent Th1 response mark the early phase of tuberculous pleurisy and suggest that down-modulation of this response, with the possible participation of IL-10, is associated with disease resolution.
- Published
- 2006
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