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The paper reveals the essence and content of the concept of ‘artistic and aesthetic consciousness of the teacher,’ where aesthetic consciousness is defined as one that determines the attitude to the phenomena of nature and culture and reveals their value aspects. The author analyzes the main components of artistic and aesthetic consciousness, which are aesthetic sense, aesthetic taste, aesthetic ideal, and shows art as a means of emotional development of the world, which becomes possible only in a socio-cultural environment by mastering certain cultural standards and cultural heritage. Given that art in the aggregate of its artistic images is a spiritual, ideal model of the world, which reflects not so much the real world as the desired, the author defines it as the basis of the spiritual culture of the era, its collective memory. Analyzing the essence and content of the concept of a music teacher’s artistic and aesthetic activities in today's conditions the following factors acquire: possession of a high level of professional training in various fields of music, on which their profession is based; possession of a wide range of creative skills in the field of music; ability to use various forms of work that contribute to the setting-up creative activity, interest in music lessons; ability to apply different types of creative activities in each lesson, based on the content of the development of aesthetic consciousness of future teachers of music; conscious understanding of the essence and content of the concept of a music teacher’s artistic and aesthetic activity in today's conditions. Artistic and aesthetic consciousness is the basis of the professional competencies of a music teacher, who extrapolates musical and aesthetic values into the educational process of student youth, forming their aesthetic culture., У статті розкрито сутність і зміст поняття «художньо-естетична свідомість учителя». Автор аналізує основні компоненти художньо-естетичної свідомості: естетичне почуття, естетичний смак, естетичний ідеал, показує мистецтво як засіб емоційно-почуттєвого освоєння світу, що стає можливим лише в соціокультурному середовищі шляхом засвоєння певних культурних норм і культурних надбань. Зважаючи на те, що мистецтво в сукупності його художніх образів є духовною, ідеальною моделлю світу, яка відображає не стільки реальний світ, скільки бажаний, автор визначає його як основу духовної культури епохи, її колективну пам’ять.

The paper proposes a new filtration model for studying the distribution of one component of the two-component body fluid and the fluid velocity in a two-layered capillary in stationary conditions. The proposed mathematical model considers such important phenomena as concentration expansion and viscosity-concentration dependence. The fluid flow correlates with the Brinkman model. Identified are the dimensionless groups, which connect different physical processes with each other. It is shown, how the model parameters affect the body fluid filtration via the two-layered capillary wall of various porosity. The motion and distribution of the fluid component are analyzed for different properties (porosity, phase mobility and size) of the inner porous layer.

Environmental pollution in large industrialized cities has become an urgent global problem. On the territory of the Russian Federation, a tense ecological situation is developing in almost all cities with a population of over one million and in large administrative centers. The creation of a quality urban environment is a national priority, a complex and financially costly task, the solution of which cannot be postponed any longer. The main sources of problems in the territories occupied by cities lie in the concentration of production capacities, the steady growth of the population, and as a result, the amount of transport. Due to production, industrial cities concentrate substances of natural and man-made origin forming local and even regional geochemical anomalies in various landscapes. Among all the interrelated components, a special place belongs to the depositing (accumulating) media–soils and bottom sediments. Based on the results of geochemical studies of 2018–2020, the indicators of the quality of the soils of Voronezh were determined, the levels of the content of pollutants of I-III hazard classes in the soils of urban and peripheral areas of Voronezh (benzo(a)pyrene and heavy metals) were established. The authors provide an assessment of the accumulation of pollutants in the bottom sediments of the Voronezh water reservoir, which is located on the territory of the urban district.

This article is a continuation of the authors’ research on improving the flotation process for fine tin products using zeta potential measurements on particle surfaces. The aim of the research is to establish the possibility of using certain reagents to intensify the flotation of fine cassiterite particles and to identify the mechanism behind the effect produced by the reagents on the surface of slurry particles in cassiterite flotation using zeta potential measurements. The results of experiments to select the best collector are presented, with salicylhydroxamic acid identified as the best option. Sodium hexametaphosphate pretreatment of a flotation slurry consisting of fine particles enables a more efficient cassiterite flotation, which is explained by the negative value of the z-potential for the particle surface. The use of sodium hexametaphosphate improves the yield by up to 3 %, with the mass fraction of tin growing from 1.2 to 1.75 %, and the recovery improving from 40 to 75 %. The results of z-potential measurements for the particle surface in the process of flotation indicate that its positive values are not always required and that the combined action of oxalic and sulfuric acids with salicylhydroxamic acid at a z-potential of –0.7 mV renders the maximum tin grade of 2.22 % in the froth flotation product. Gravity treatment of the flotation concentrate on concentration tables allows obtaining conditioned concentrates with the mass fractions of tin of 23.4 and 30.6 %. Finding the extremum of the z-potential for the particle surface during the flotation of tin minerals allows predicting the concentration results.

This article presents the 3D computational modeling method for reinforced concrete structures. An example of calculation of the reinforced concrete beam, using the Finite Element Method in SCAD++ following proposed algorithm, is given. Results comparison to the analytical calculation of the model with selected reinforcement is presented. For concrete, the 3D solid Finite Elements are used and the 3D beam elements for reinforcement. The model is formed using AutoCAD and AutoLISP, which creates a text data file in SCAD format for the description of model. In addition, computation of the 3D model of the crossbar with a crack is performed. Crack sizes are set in the stretched zone based on data from initial calculation. Graphic results obtained in SCAD++ are presented.

A model of filtration of a biological fluid for a cylindrical layer in a stationary regime is presented. The model takes into consideration finite compressibility and concentration expansion associated with barodiffusion. Dimensionless complexes relating characteristic physical scales of different phenomena are singled out. The influence of the revealed effects on the flow characteristics are studied numerically. The flow can be either convective or diffusive, depending on the relation between the dimensionless complexes. New qualitative relationships are distinguished in the component concentration and flow velocity distributions. A significant influence of the thickness of the porous cylinder wall is shown. It is found out that barodiffusion has a significant effect on the flow in the convective mode and a small cylinder wall thickness.

The results of studying the morphology, porous structure, and corrosion and diffusion properties of boehmite-containing calcium phosphate coatings formed by microarc oxidation on titanium substrates are presented. Boehmite nanoparticles obtained as a result of the AlN hydrolysis were deposited on the surface of microarc coatings with a developed relief. With an increase in the duration of the preliminary ultrasonic treatment (UST) of the AlN suspension in the interval of 20–60 min, the size of agglomerates of boehmite nanoparticles on the coating surface is decreased from 200 to 40 μm. The surface porosity of the modified coatings and the area occupied by boehmite particles are decreased from 36 to 33% and from 27 to 10%, respectively. Agglomerates with boehmite nanoparticles after 60 min of UST of an AlN powder suspension are distributed in the coating more uniformly than after 20 min of treatment. When the duration of UST of the initial suspensions is increased, the effective diffusion coefficients of the model biological fluid in porous coatings is decreased from 7.98 × 10–11 to 7.25 × 10–11 m2/s. Modification of calcium phosphate coatings with boehmite nanoparticles by varying the duration of UST of AlN powder increases the corrosion resistance of the surface layers.

On the example of urban soils of the city of Voronezh there was revealed dependence of the degree of the disturbance of complexes of filamentous microorganisms on soil contamination levels. For the complex of micromycetes in the recreational area of the city disturbances are reversible and correspond to the adaptive range of "stress". In the transport an irreversible transition originates to the adaptive range of "resistance". There are accumulated toxigenic, opportunistic and allergenic fungi species that is harmful to the health of the urban population. The complex of soil actinomycetes is more sustainable. Microbiological indices (lists of indicative species offungi) should be used for the monitoring of urban soils.

The comparative expert and statistical estimation were executed for ecological-coenotical groups system and coenomorphs of A.L. Belgard by example of Khanty-Mansi Autonomous Area – Yugra vascular plant flora. Both systems have given appropriate estimations, correspond to principal abiotic factors gradients and groups locations in phytometer scales. For both classifications identical principal abiotic factors have been detected, but systems differ for inverse ordination vectors of this factors gradients. For the region is recommend using of joint meadow and joint paludal groups, separate oligotrophic bog and ruderal groups and specified of sylvatic group., Для флоры сосудистых растений Ханты-Мансийского автономного округа – Югра выполнена сравнительная экспертно-статистическая оценка системы эколого-ценотических групп и ценоморф А.Л. Бельгарда. Обе системы дают адекватные оценки, соответствующие градиентам ведущих абиотических факторов региона и положению групп в фитоиндикационных шкалах. Для обеих классификаций определяются одинаковые ведущие экологические факторы, но системы отличаются противоположными векторами ординации по градиентам этих факторов. Для региона рекомендуется использование объединенных луговой и болотной, выделение олиготрофной и рудеральной и детализация лесной ценотической групп.

In the present work a model of the evolution of the composition of the transition zone between the material and the pre-applied coating under conditions of intense short-term thermal impulse is proposed. The pulse times are assumed to be comparable to the relaxation times of the heat and mass fluxes. This led to the need to account for finite rates of heat and mass propagation in the model, leading to hyperbolic transfer equations. The phenomena of thermodiffusion (Soret effect) and diffusive thermal conductivity (Dufour effect) and some possible chemical reactions leading to a change in the transition zone composition are also taken into account. This nonlinear model problem illustrates the necessity of the really coupled problem solution to reveal the feature of cross-effects in irreversible conditions. It was found that due to the wave heating and the wave nature of the movement of elements, chemical reactions can start during the action of a short pulse outside the heating zone expected only due to thermal conductivity.

TPS3155 Background: B7-H4, a B7 immune checkpoint ligand, is expressed at low levels in normal tissue and negatively regulates T-cell function by inhibiting T-cell proliferation and cytokine production. B7-H4 expression is elevated in solid tumors, including breast, ovarian, and endometrial cancers. Targeting B7-H4–expressing tumor cells may relieve B7-H4–mediated T-cell inhibition. SGN-B7H4V is a novel, investigational vedotin antibody–drug conjugate directed to B7-H4 with proposed mechanisms of action including monomethyl auristatin E (MMAE)-directed cytotoxicity, bystander effect, antibody-dependent cellular cytotoxicity, and antibody-dependent cellular phagocytosis. SGN-B7H4V elicited antitumor activity in cell line-derived xenograft models of triple-negative breast cancer (TNBC) and patient-derived xenograft models of TNBC and ovarian cancer (Gray et al 2021), providing a rationale to evaluate SGN-B7H4V in patients (pts) with advanced solid tumors. Methods: SGNB7H4V-001 (NCT05194072) is a phase 1, first-in-human, multicenter, open-label trial evaluating the safety, tolerability, pharmacokinetics (PK), and antitumor activity of SGN-B7H4V in pts with advanced solid tumors. This study includes 3 parts: dose escalation (Part A), dose and schedule optimization (Part B), and dose expansion in disease-specific cohorts and a biology cohort (Part C). Adult pts (≥18 years) with histologically/cytologically confirmed locally advanced unresectable or metastatic solid tumors including high-grade serous epithelial ovarian cancer, primary peritoneal cancer, fallopian tube cancer, human epidermal growth factor receptor 2-negative and hormone receptor-positive breast cancer, TNBC, endometrial carcinoma, squamous non-small cell lung cancer, cholangiocarcinoma, or gallbladder carcinoma, are eligible. Pts must have ECOG PS 0–1 and relapsed/refractory disease or be intolerant to standard-of-care therapies. Prior treatment with an MMAE-containing agent or a B7-H4–targeted agent is not permitted. Primary endpoints include the rate of adverse events, laboratory abnormalities, dose-limiting toxicities, and cumulative dose-level safety. Secondary endpoints are objective response rate (ORR), complete response rate, duration of objective response (DOR), progression-free survival (PFS), overall survival (OS), PK, and incidence of antidrug antibodies. Exploratory endpoints include pharmacodynamic (PD) analyses, PD and PK exposure measurements, B7-H4 characterization on malignant cells, and biomarker analyses. Safety and antitumor activity endpoints will be assessed using descriptive statistics. ORR will be analyzed by tumor type and dose. DOR, PFS, and OS will be estimated using the Kaplan–Meier method. Enrollment for Part A is ongoing in North America and is planned in Europe. Clinical trial information: NCT05194072.

Indicator for urban load species of soil micromycetes synthesize mycotoxins of a wide range of toxic effects and cause a significant increase in phytotoxic activity of the soil in the transport zone of the city.

The treatise proposes a model of biological fluid transfer in a dedicated macropore with microporous walls. The distribution of concentrations and velocity studies in the capillary wall for two flow regimes—convective and diffusive. The largest impact on the redistribution of concentration between the capillary volume and its porous wall is made by Darcy number and correlation of diffusion coefficients and concentration expansion. The velocity in the interface vicinity increases with rising pressure in the capillary volume or under decreasing porosity or without consideration of the concentration expansion.

Tin-bearing tailings of the Solnechny Mining and Processing Plant (MPP) in the Khabarovsk Territory are studied with a view to producing tin and copper concentrates. The features of the material constitution of tailings and their influence on the process flow diagram (PFD) development are described. Processability of the Solnechny MPP tailings is tested, and PFD is developed using the modern methods of disintegration, including cavitation and ultrasound. The semi-commercial-scale implementation of the proposed PFD has allowed production of copper concentrate at copper content of 18.28% and recovery of 60.48%, tin concentrate at tin content of 11.35% and recovery of 50.88%, and rejects with the tin and copper contents of 0.139 and 0.154%, respectively. The recovery of tin and copper has made 46.66 and 38.45%.

The morphology and the structure of zinc- or copper-containing calcium phosphate coatings deposited by the microarc oxidation (MAO) method at different voltages on pure titanium and low-modulus Ti-40 wt % Nb alloy substrates are investigated. The morphology of the MAO coatings on both substrates is composed of sphere-shaped structural elements 8–42 μm in size and pores 1–15 μm in size. When the process voltage is increased from 200 to 300 V, these structural elements grow and partially destruct. It is ascertained that the MAO voltage increase leads to the linear increase in the surface porosity of the coatings from 14 to 24%. It is established that the effective diffusion coefficients of the model biological fluid in porous coatings vary from 0.85 × 10–10 to 9.0 × 10–10 m2/s. Under the increase in the structure element size, the effective diffusion coefficient of the model biological fluid increases in the MAO coatings deposited on a titanium substrate and decreases in those deposited on Ti-40 wt % Nb alloy. The observed difference is related to the increase in the crystalline phase fraction.

This research is to assess the efficiency of canned vegetables production. In order to plan the production activities a wide range of parameters is analyzed, for instance the costs production, profit, market, finance, taxation system and political situation. However, the assessment of these parameters is necessary with reference to a specific aims and tasks. The specific time or period, which those parameters are assessed within, is also important. Here the process of launching into production of 2 kinds of canned vegetables on a new production line is considered. The assessment of production efficiency is given on the base of Net Present Value (NPV), internal rate of return (IRR), productivity index. The obtained data proves the expediency of the project; its implementation will increase the economic stability of the enterprise.

A model of the growth of a calcium phosphate coating on a zirconium substrate with respect to the formed oxide sublayer and formation of phases is proposed. The influence of the parameters of the model on the growth of the coating and the evolution of the stresses in the oxide layer and in the coating is investigated. It is shown that the content of the substances formed in the coating increases with the increasing constants of the reaction rates, increasing diffusion coefficients, or with a decreasing voltage of the process. It is shown that the stresses in the vicinity of the interface (the substrateoxide layer) are higher when there is an oxide layer than in its absence.

На протяжении последних 25 лет ведущие российские производители коагулянтов непрерывно работают над оптимизацией процессов, технологий, реагентов, сооружений и оборудования, связанных с коагуляционной обработкой воды, в первую очередь специфических по составу водоисточников рек Северо-Запада и Юга России, Западной Сибири, Дальнего Востока, Казахстана и др. Эффективным решением для очистки воды сложного состава являются смесевые коагулянты, принцип действия которых основан на синергетическом эффекте взаимодействия компонентов. В мае 2020 г. вступает в силу новый ГОСТ Р 58580-2019 Полиоксихлорид алюминия. Технические условия , который рекомендует водоканалам РФ применение реагента независимо от специфических особенностей водоисточников, используемых для водоснабжения. В данном стандарте необоснованно регламентируются некоторые показатели, в частности содержание железа. Это обесценивает усилия ученых и практиков, направленные на совершенствование процессов очистки воды сложного состава с использованием железосодержащих смесевых реагентов.Over the past 25 years the leading Russian manufacturers of coagulants have been continuously busy with the optimization of processes, technologies, chemicals, facilities and equipment associated with coagulation of water primarily from water sources of specific composition rivers of the North-West and South of Russia, Western Siberia and the Far East, Kazakhstan, etc. Mixed coagulants based on the synergistic effect of the interaction of components provide for an effective solution for purifying water of complex composition. In May 2020, the new GOST R 58580-2019 Polyaluminum chloride. Technical Specifications will come into effect that recommends the use of the chemical to the Russian water utilities regardless of the specific characteristics of the water sources used for water supply. This standard unreasonably regulates a number of indicators, iron concentration, in particular. This devaluates the efforts of researchers and practitioners aimed at improving the processes of purifying water of complex composition using iron-containing mixed chemicals.

3001 Background: Glutamine metabolism is frequently deregulated in different cancers, including tumors harboring KEAP1/ NFE2L2 mutations or those expressing low Asparagine Synthetase (ASNS) levels. IACS-6274 is a potent oral GLS1 inhibitor discovered at MD Anderson Cancer Center with excellent pharmacokinetics (PK) and antitumor activity in biomarker-defined preclinical models. Methods: Pts with advanced solid tumors received IACS-6274 BID at escalating doses using a phase 1 BOIN design. PK and pharmacodynamic (PD) studies were conducted in serial tumor and/or blood samples. Peripheral glutamine metabolism was assessed in peripheral blood mononuclear cells (PBMC) to assess glutamine metabolism via 13C-isotope labelling. Predictive biomarker studies included tumor analyses for KEAP1, NFE2L2, STK11, NF1 mutations and IHC for ASNS loss. Results: 22 pts with advanced ovarian (n=8), NSCLC (n=7), melanoma (n=2), leiomyosarcoma, gastric, anal, endometrial and HNSCC (all n=1) received IACS-6274 at 20 (n=1), 40 (n=1), 80 (n=1), 120 (n=4), 180 (n=11) or 240 (n=4) mg BID. Molecular alterations assessed included pts with ASNS loss (n=6), STK11 (n=5), KEAP1 (n=5), NFE2L2 (n=4) and NF1 (n=1). Prior lines of therapies: 2-4 (n=12); ≥5 (n=10). Common IACS-6274-related adverse events included G1-2 photopsia (n=7), photophobia (n=7), increased creatinine (n=4) and AST (n=4). Less common G3 toxicities at 180 and 240 mg included reversible nausea (n=3), vomiting and fatigue (n=2). Dose-limiting toxicities of G3 acute renal failure and PRES syndrome were seen in one patient at 240mg BID, which fully resolved. Plasma exposures showed a dose-dependent increase across doses with observed half-life ̃12 hrs. Patients at 180mg displayed steady-state exposures at C1D14 with Cmax of 45.8 μM +/- 18.6 μM and average AUC(0-12hrs) of 382.48 h*μM +/- 159.27 h*μM. Glutamate to glutamine ratios decreased in PBMC samples in pts at C1D14 vs baseline; pts at 120, 180 and 240 mg had inhibition of 82.5% (P

TPS3144 Background: The extracellular matrix (ECM) plays an important role in solid tumor pathogenesis and is a major focus of research and therapeutic targeting. Integrin beta-6 is a cell surface receptor that interacts with the ECM to mediate cellular adhesion. Integrin beta-6 is overexpressed in numerous solid tumors and its expression is a negative prognostic marker in cancers including colorectal, non-small cell lung, gastric, and cervical cancers. SGN-B6A is an investigational vedotin, an antibody-drug conjugate directed against integrin beta-6 to selectively deliver the cytotoxic agent monomethyl auristatin E, which binds tubulin and induces apoptosis. In multiple xenograft models, treatment with SGN-B6A resulted in tumor growth delay and regression in tumor volume when compared to non-binding control. Methods: SGNB6A-001 (NCT04389632) is a phase 1, first-in-human, open-label, multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and antitumor activity of SGN-B6A in adults with select advanced solid tumors. Primary objectives are to evaluate the safety and tolerability of SGN-B6A in patients with advanced solid tumors, identify the maximum tolerated dose, and identify a recommended dose and schedule. The study has 2 parts: dose escalation (Part A) and dose expansion with multiple disease-specific cohorts and a biology cohort (Part B). SGN-B6A will initially be given by intravenous infusion on Days 1, 8, and 15 of 21-day cycles. The dose escalation (Part A) will be conducted using the modified toxicity probability interval method to determine a dose that demonstrates a dose-limiting toxicity rate of 25% with a 5% margin. The dose and schedule for Part B will be determined based on evaluation of safety, PK, and pharmacodynamic biomarkers. Response evaluations will be based on RECIST v1.1. Patients must be ≥18 years old and have histologically or cytologically confirmed metastatic or unresectable solid malignancy within one of the following tumor types: non-small cell lung cancer, head and neck squamous cell cancer, breast cancer, esophageal cancer, ovarian cancer, cutaneous squamous cell cancer, exocrine pancreatic adenocarcinoma, bladder cancer, cervical cancer, or gastric cancer. After an appropriate dose and schedule are determined in Part A, safety and preliminary antitumor efficacy of SGN-B6A will be evaluated in indication-specific cohorts (Part B). This study is ongoing in sites across North America and Europe. Clinical trial information: NCT04389632.

The article examines the trends in the spatial distribution of air temperature and precipitation indicators on the territory of the Chelyabinsk region for the period from 1936 to 2019. The average annual temperatures and precipitation were analyzed for 24 meteorological stations of the Chelyabinsk region. The results obtained made it possible to differentiate the study area according to the conditions of the thermal regime and the regime of humidification. The amplitudes of temperature growth were determined with a tendency to an increase in the number of differentiated zones, while a shift of the warming boundary to the north was noted. In mountainous areas, low temperature zones are shrinking and shifting to the northwest. The precipitation regime is orographic in nature, but there is a tendency towards a decrease in the continuity of the identified zones, as well as greater moisture content in the territory of steppe (arid) landscapes, which play an important role in agricultural production in the Chelyabinsk region.

The study presents the features of the spatial distribution of temperatures and precipitation within the Southern Urals based on the analysis of daily observations within 2004–2018. The study suggests the reasons for zones of temperature and precipitation distribution. There is a nature of the formation of climatic zones by the regime of moistening determined. The azonal differences of the western and eastern slopes of the Southern Urals are differentiated. Local causes of latitudinal differences in temperature and meridional physiographic features are shown. Monitoring observations of the annual course of precipitation and multidimensional classification identified 5 humidification zones. The causes are described by discriminant functions. This complicates the analysis of altitudinal differentiation and enhances the role of azonal factors. A set of identified causes is formed, including during human activities.

The importance of the formation of a constructive life position of air transport specialists, on whom the safety of life of passengers depends, is actualized. The psychological meaning of the concept of “personality life position” and its main vectors, including activity-passivity, constructiveness-destructiveness, spirituality-lack of spirituality, negativity-positivity, selfishness-collectivism, morality-immorality, etc. are considered. The main personality characteristics that influence the development of a constructive life position are identified, including: value orientations and motives, life goals and meanings, attitudes towards altruism and optimism, ability to predict the future and make life decisions, choice of strategy for achieving goals, ability to self-determination. The conceptual model of formation of a constructive life position of air transport specialists is presented. To identify indicators and characteristics that affect the process of formation of a constructive life position, the main strategies for achieving personality goals are studied: passive strategy; active-rigid strategy; active-plastic strategy; mixed strategy. The selection of diagnostic tools is made, and the results of empirical research, which showed that modern young men and women need psychological and pedagogical assistance in determining their own constructive life position as a basic, which leads to the feeling of happiness and life satisfaction are presented. Conclusions are made, according to which the process of formation of a life position of the personality of an Aviation University student should be focused on a constructive direction. This presupposes the urgent need to create in higher educational institutions favorable psychological and pedagogical conditions for preparing young people for the development of a constructive life position.

9069 Background: Most patients with extensive SCLC develop drug resistance to platinum-based 1L therapy or discontinue for other reasons, and second-line (2L) therapies are limited. RESILIENT (NCT03088813) is a two-part phase 2/3 study assessing the safety, tolerability and efficacy of 2L liposomal irinotecan monotherapy in adults with SCLC who progressed with platinum-based 1L therapy. Preliminary data from RESILIENT part 1 (cut-off May 8 2019; ≥ 12 weeks follow-up) showed that liposomal irinotecan 70 mg/m2 free base every 2 weeks was generally well tolerated and had encouraging antitumor activity (Paz-Ares et al. WCLC 2019 OA03.03). Objective response rate (ORR; secondary endpoint) was 44% (11/25). Here we report efficacy analyses in post hoc subgroups by platinum sensitivity. Methods: RESILIENT part 1 was an open-label, single-arm study comprising dose-finding and dose-expansion phases. Eligible patients were aged ≥ 18 y, with an ECOG performance status score of 0/1 and adequate organ function; a single line of prior immunotherapy was allowed. Participants received liposomal irinotecan 70 mg/m2 or 85 mg/m2 free base every 2 weeks, with tumor assessments every 6 weeks (RECIST v1.1). Analyses were undertaken for the dose-finding phase recommended dose (RD) in subgroups of platinum-resistant/sensitive patients (with/without progression within 90 days from completion of 1L therapy). Results: During dose finding, 5 patients received liposomal irinotecan 85 mg/m2 (deemed not tolerable; dose-limiting toxicity) and 12 received 70 mg/m2 (deemed tolerable; RD for dose-expansion phase in which 13 more patients were included). Analyses included all 25 patients receiving the RD (mean exposure, 13.95 weeks [median 14.86; SD 7.222]). In the platinum-sensitive subgroup (33.3% men; median age 62.0 y) ORR was 53.3% (8/15) and 12-week disease control rate (DCR12wks) was 60% (9/15); in the platinum-resistant subgroup (50% men, median age 58.0 y) both ORR and DCR12wks were 30% (3/10). Overall and progression-free survival (secondary endpoints) are not yet mature. Conclusions: ORR and DCR12wks were numerically higher in platinum-sensitive than in platinum-resistant patients with SCLC who had progressed with platinum-based 1L therapy before receiving 2L liposomal irinotecan 70 mg/m2 in this phase 2 study. RESILIENT part 2, an ongoing, phase 3, randomized controlled trial vs topotecan, will provide further data. Clinical trial information: NCT03088813.