83 results on '"N. J. O’Higgins"'
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2. Irish association for cancer research
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F. Gannon, R. C. Forde, P. V. Nester, P. Webb, J. McCaffrey, J. J. Fennelly, D. McCarthy, J. Halligan, P. Crosby, A. Long, D. Kelleher, J. Keane, T. O’Riordan, D. S. O’Briain, P. A. Daly, R. Sheahan, A. M. Jawas, J. C. O’Reane, M. J. Murnane, N. Corbally, D. Devaney, L. Grogan, P. A. Dervan, D. N. Carney, A. Duggan, F. O’Brien, G. O’Sullivan, J. K. Collins, H. A. Long, D. J. Conway, P. M. Mercer, D. Murphy, M. Stokes, K. Sheahan, N. J. O’Higgins, P. P. A. Smyth, M. A. O’Connell, L. O’Neill, A. Nugent, J. Gallagher, J. Dolan, D. Bermingham, E. McDermott, N. O. Higgins, M. J. Duffy, E. W. McDermott, D. S. Murphy, M. Sharp, J. J. Murphy, N. O’Higgins, W. Ormiston, P. Donnellan, R. McManus, M. S. Ashraf, J. Brady, F. Breatnach, P. F. Deasy, A. O’Meara., M. Doran, E. W. M. McDermott, M. Cassidy, K. S. Cross, N. J. O’Higgins., P. A. Dervan., N. Gardiner, M. Lawler, P. Humphries, S. R. McCann., T. Mahon, L. A. J. O’Neill., O. Shiels, E. Gaffney, P. A. Daly., D. P. Hollywood, W. C. Hurst., F. M. Lyng, C. Mothersill, D. C. Cottell, J. E. Trosko, G. O’Keefe, S. McCann, K. Sweeney., M. Sheridan, C. B. Seymour, J. Harney., D. Grehan, T. Walshe, K. Hickey, T. Hennessy, P. Mercer, J. Reynolds, S. Cross, N. O’Higgins., D. Morrissey, D. Lynch, G. O’Sullivan., S. Verhaegen, T. Cotter., A. McGahon, K. Cotter, D. Green, D. Samson, M. Evans, J. Treleaven, J. Barrett, J. McMahon, E. F. Gaffney, O. Sheils, M. McCabe, H. Lambkin, P. Kelehane, J. M. Glynn, D. R. Green, T. G. Cotter, A. M. O’Mahony, G. C. O’Sullivan, K. M. Molloy, S. R. McCann, J. O’Riordan, K. Molloy, I. McShane, L. Kelleher, H. Magee, K. O’Byrne, D. Lyons, E. O’Toole, C. O’Donnell, N. O’Hare, P. Freyne, L. Clancy, J. Ennis, J. Prichard, E. McGovern, D. Luke, D. Carney, M. R. Kenealy, M. Keaveney, P. Nestor, S. Duggan, H. P. Redmond, J. McCarthy, R. G. W. Watson, D. T. Croke, P. Burke, D. Bouchier-Hayes, R. W. G. Watson, R. O’Donnell, M. McCarthy, N. O’Donovan, J. K. Collins., J. O’Connell, D. Phelan, C. Hanvajanawong, M. Morrin, M. Kelly, F. Khan, N. Barrett, and P. Delaney
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medicine.medical_specialty ,Irish ,business.industry ,Family medicine ,language ,Medicine ,General Medicine ,business ,language.human_language - Published
- 1994
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3. Metalloproteinases: role in breast carcinogenesis, invasion and metastasis
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Enda W. McDermott, Michael J. Duffy, T. Maguire, N. J. O’Higgins, and Arnold Dk Hill
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Pathology ,medicine.medical_specialty ,Gelatinases ,Apoptosis ,Breast Neoplasms ,Review ,Matrix metalloproteinase ,Biology ,medicine.disease_cause ,Basement Membrane ,Metastasis ,Substrate Specificity ,Extracellular matrix ,Breast cancer ,breast cancer ,Surgical oncology ,medicine ,Biomarkers, Tumor ,metastasis ,Humans ,Neoplasm Invasiveness ,Protease Inhibitors ,Receptors, Growth Factor ,Neoplasm Metastasis ,skin and connective tissue diseases ,Growth Substances ,Extracellular Matrix Proteins ,Neovascularization, Pathologic ,matrix metalloproteinases ,Metalloendopeptidases ,Tissue inhibitor of metalloproteinase ,medicine.disease ,invasion ,Prognosis ,Neoplasm Proteins ,Protein Structure, Tertiary ,Cancer research ,tissue inhibitor of metalloproteinase ,Disease Progression ,Female ,Carcinogenesis ,carcinogenesis - Abstract
The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 members of this family are known to exist. Based on substrate specificity and domain organization, the MMPs can be loosely divided into four main groups: the interstitial collagenases, gelatinases, stromelysins and membrane-type MMPs. Recent data from model systems suggest that MMPs are involved in breast cancer initiation, invasion and metastasis. Consistent with their role in breast cancer progression, high levels of at least two MMPs (MMP-2 and stromelysin-3) have been found to correlate with poor prognosis in patients with breast cancer. Because MMPs are apparently involved in breast cancer initiation and dissemination, inhibition of these proteinases may be of value both in preventing breast cancer and in blocking metastasis of established tumours
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- 2000
4. High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancer
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Enda W. McDermott, Kevin McCarthy, T. Maguire, Gerald T McGreal, Michael J. Duffy, and N. J. O’Higgins
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Cancer Research ,medicine.medical_specialty ,Mammary gland ,Estrogen receptor ,Cancer ,Matrix metalloproteinase ,Tissue inhibitor of metalloproteinase ,Biology ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,Breast cancer ,Oncology ,Tumor progression ,Internal medicine ,medicine ,Carcinoma ,Cancer research - Abstract
Studies from model systems suggest that matrix metalloproteinases (MMPs) are causally involved in tumor progression while tissue inhibitors of MMPs (TIMPs) prevent this progression. Here, we show that concentrations of TIMP-1 are significantly higher in breast carcinomas than in fibroadenomas. In primary breast cancers, TIMP-1 concentrations increased with increasing tumor size but showed an inverse relationship with estrogen receptor concentrations. In primary breast cancers also, TIMP-1 levels were weakly but significantly correlated with those for MMP-1, proMMP-2, active MMP-2, MMP-3 and proMMP-9. Contrary to what might be expected from published data on model systems, high concentrations of TIMP-1 predicted a poor outcome in patients with breast cancer. We conclude that in human breast cancer, endogenous TIMP-1 does not inhibit tumor progression but may enhance the process. Int. J. Cancer (Pred. Oncol.) 84:44–48, 1999. © 1999 Wiley-Liss, Inc.
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- 1999
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5. Preoperative CA 15-3 concentrations predict outcome of patients with breast carcinoma
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Enda W. McDermott, N. J. O’Higgins, S. G. Shering, Michael J. Duffy, and Frances Sherry
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Cancer Research ,medicine.medical_specialty ,Axillary lymph nodes ,business.industry ,Estrogen receptor ,Cancer ,CA 15-3 ,medicine.disease ,Primary tumor ,Gastroenterology ,Surgery ,medicine.anatomical_structure ,Oncology ,Internal medicine ,medicine ,Carcinoma ,Breast carcinoma ,business ,Estrogen Receptor Status - Abstract
BACKGROUND CA 15-3 is a breast-associated mucin that is elevated in the majority of breast carcinoma patients with distant metastases. Currently, the main application of this marker is in monitoring and detecting recurrences in patients with diagnosed breast carcinoma. METHODS Preoperative serum concentrations (prior to excision of the primary tumor) of CA 15-3 were measured in 368 patients undergoing potentially curative surgical treatment for early breast carcinoma. These results were compared with prospectively recorded clinicopathologic characteristics and patient outcome data. RESULTS A weak but significant positive association was found between CA 15-3 concentrations and both tumor stage and the number of involved axillary lymph nodes but not between CA 15-3 concentrations and estrogen receptor status. Patients with high concentrations of CA 15-3 had a significantly worse prognosis than patients with low concentrations. Using an optimum cutoff value of 30.38 U/mL, the probability of disease free survival at 5 years was 44% in patients with high CA 15-3 levels compared with 65% in patients with low CA 15-3 levels (P = 0.002, Mantel-Cox log rank test). The corresponding probabilities for overall survival were 67% and 83%, respectively (P 2 cm in greatest dimension, and patients with estrogen receptor positive tumors). CONCLUSIONS Preoperative serum concentrations of CA 15-3 appear to have a significant relation to outcome in patients with early breast carcinoma and may have a role in the rational selection of patients for appropriate adjuvant treatments. To the authors' knowledge, CA 15-3 thus is one of the first circulating markers shown to be an independent prognostic indicator in patients with breast carcinoma. Cancer 1998;83:2521-2527. © 1998 American Cancer Society.
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- 1998
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6. Irish endocrine society: 23rd annual meeting
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W. J. Kokaly, T. J. McKenna, W. M. Kong, D. O’sShea, J. Alaghband-Zadeh, J. Jones, G. Carter, P. P. A. Smyth, C. O’Herlihy, J. H. Lazarus, L. D. K. E. Premawardhana, A. B. Parkes, C. S. Kularatna, A. Rees, J. Evans, C. Wijeyaratne, H. Da Silva, A. Gleeson, K. Anderton, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, D. Smith, F. Finucane, K. McKenna, J. Finucane, C. J. Thompson, J. Phillips, E. M. McConnell, A. B. Atkinson, C. Ennis, D. R. McCance, D. R. Hadden, B. Sheridan, P. M. Bell, A. M. Suliman, F. Al-Saber, F. Hayes, T. Fiad, M. Culliton, S. Cunningham, T. P. Smith, W. Campbell, C. F. Johnston, W. J. Curry, K. D. Buchanan, A. C. Leary, G. Grealy, T. M. Higgins, N. Buckley, D. G. Barry, J. B. Ferriss, K. M. S. McNeill, R. T. Cunningham, J. A. O’Hare, P. Burke, P. Grace, E. Murphy, J. Reynolds, J. J. Nolan, N. N. Chan, D. Darko, A. Jackson, W. S. Dhillo, D. O’Shea, M. T. Kilbane, R. A. Ajjan, A. P. Weetman, S. G. Shering, E. W. M. McDermott, N. J. O’Higgins, ÁA. N. Johansson, D. O’Kane, J. D. Allen, C. H Courtney, A. S. McAllister, B. T. Kinsley, T. Smith, J. MacMahon, H. Leslie, D. Cannon, D. Powell, C. H. Courtney, P. T. McSorley, C. N. Ennis, I. S. Young, and J. P. H. Fee
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Sodium-iodide symporter ,medicine.medical_specialty ,business.industry ,Thyroid ,Cancer ,General Medicine ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,Cell culture ,Internal medicine ,medicine ,Endocrine system ,skin and connective tissue diseases ,business ,Receptor ,Incubation ,Thyroid cancer - Abstract
C CLARKE, CG BRENNAN, K RODGERS, RM DWYER, PPA SMYTH ENDOCRINE LABORATORY, DEPARTMENT OF MEDICINE AND THERAPEUTICS, UNIVERSITY COLLEGE DUBLIN, IRELAND he demonstration in extrathyroidal human tissues of the sodium iodide symporter (NIS) has raised the possibility that 1311, commonly used as a systemic therapeutic ablative agent in hyperthyroidism and thyroid cancer, might be applied in the treatment of tumours in other NISexpressing tissues such as human breast cancer. Thyroidal transport of 1311 is known to be proportional to circulating stable I and the aim of this study was to determine how stable I (KI) would effect such transport in human breast cancer cell lines MDA-MB-231, MCF-7 and in FRTL-5 thyroid cells. All cells were incubated with KI (01 00mM) for 72 hours after which 1Th I was added . Incubation and uptake of 'l by cells was counted every four hours. Timed efflux of '^I was measured every five minutes. KI in the incubation medium blocked 1251 uptake in a dose-dependent manner in the E receptor positive MCF7 cell line. The effect was less marked in the E receptor negative MDA-MB-231 with significant uptake being maintained even at an I concentration of 50mM. A similar blockade was seen in the FRTL-5 cells with maximum uptake blockade of 25mM I. The rate of efflux of 15I was similar in both MCF-7 and MDA-MB-231 cell lines with a tin of 35 and 40 minutes respectively. In contrast, efflux from the FRTL-5 cells was faster (tire=15 mins). As the human breast has a much lower avidity for I than the thyroid, control of dietary intake would assume even greater importance in radioactive iodine treatment of breast tumours or their metastases.
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- 1998
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7. Serum Thyroid Peroxidase Autoantibodies, Thyroid Volume, and Outcome in Breast Carcinoma1
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N. J. O’Higgins, M. J. Murray, P. P. A. Smyth, Enda W. McDermott, Mark Kilbane, S.G. Shering, and D. F. Smith
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endocrine system ,medicine.medical_specialty ,biology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Thyroid disease ,Biochemistry (medical) ,Clinical Biochemistry ,Thyroid ,Mammary gland ,medicine.disease ,Biochemistry ,Endocrinology ,medicine.anatomical_structure ,Thyroid peroxidase ,Internal medicine ,medicine ,Carcinoma ,biology.protein ,Breast disease ,skin and connective tissue diseases ,Breast carcinoma ,business ,Survival analysis - Abstract
The prevalence of thyroid peroxidase autoantibodies (TPO.Ab) was assessed in patients with either breast carcinoma or benign breast disease, and its association with disease outcome in breast carcinoma was studied. TPO.Ab were detected by direct RIA in serum from 121/356 (34.0%) of patients with breast carcinoma, compared with 36/194 (18.5%) of controls (P or = 0.3 U/mL were associated with a significantly better disease-free [relative risk (RR) = 1.84, P 18.8 mL. Multivariate survival analysis showed that both TPO.Ab and thyroid volume were independently associated with prognosis in breast carcinoma and that RRs for disease-free survival were of a similar order of magnitude to well-established prognostic indices such as axillary nodal status or tumor size. These findings supply evidence that manifestations of thyroid autoimmunity are associated with a beneficial effect on disease outcome in breast carcinoma and provide the strongest evidence to date of a biological link between breast carcinoma and thyroid disease.
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- 1998
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8. Urokinase plasminogen activator: a prognostic marker in breast cancer including patients with axillary node-negative disease
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N. J. O’Higgins, Enda W. McDermott, Hugh E. Mulcahy, Michael J. Duffy, and Catherine Duggan
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Oncology ,medicine.medical_specialty ,Biochemistry (medical) ,Clinical Biochemistry ,Mammary gland ,Cancer ,Biology ,medicine.disease ,Metastasis ,medicine.anatomical_structure ,Breast cancer ,Internal medicine ,Immunology ,medicine ,Adjuvant therapy ,Estrogen Receptor Status ,Lymph node ,Survival analysis - Abstract
Urokinase plasminogen activator (uPA) is a serine protease causally involved in cancer invasion and metastasis. In this study, high concentrations of uPA in primary breast cancers were independently associated with both a shortened disease-free interval and overall survival. For the disease-free interval as endpoint, uPA was a stronger indicator of outcome than lymph node status, whereas for overall survival, nodal status was stronger than uPA. In patients without metastasis to axillary nodes, uPA was also an independent prognostic marker, using both the disease-free interval and overall survival as end points. In contrast to uPA, neither tumor size nor estrogen receptor status was prognostic in the node-negative patients. Measurement of uPA concentrations might thus be of value in selecting the more aggressive subpopulation of node-negative breast cancer patients that could benefit from adjuvant therapy.
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- 1998
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9. Sylvester o’halloran surgical scientific meeting
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N. Relihan, G. McGreal, M. Murray, E. W. McDermott, N. J. O’Higgins, M. J. Duffy, D. A. McNamara, J. Harmey, J. H. Wang, D. Donovan, T. N. Walsh, D. J. Bouchier-Hayes, E. Kay, J. D. Kelly, H. P. Weir, P. F. Keane, S. R. Johnston, K. E. Williamson, P. W. Hamilton, D. McManus, M. Morrin, P. V. Delaney, D. C. Winter, B. J. Harvey, J. P. Geibel, G. C. O’Sullivan, C. P. Delaney, R. Coffey, T. F. Gorey, J. M. Fitzpatrick, N. F. Fanning, W. Kirwan, T. Cotter, D. Bouchier-Hayes, H. P. Redmond, G. Pidgeon, F. Fennessy, C. Kelly, R. Flavin, A. M. Rasheed, A. Leahy, E. E. Lang, M. T. P. Caldwell, W. A. Tanner, P. D. Kiely, M. O’Reilly, S. Tierney, M. Barry, J. Drumm, P. A. Grace, C. M. Gallagher, D. C. Grant, P. Connell, M. K. Barry, O. Traynor, J. M. P. Hyland, M. J. O’Sullivan, D. Evoy, W. O. Kirwan, B. Cannon, L. Kenny-Walshe, M. J. Whelton, H. O’Grady, S. O’Neill, J. M. Hyland, S. H. Teh, S. O’Ceallaigh, M. K. O’Donohoe, F. B. Keane, G. C. O’Toole, J. Calleary, L. Basso, S. B. Amjad, Z. Khan, L. McMullin, W. P. Joyce, P. J. Balfe, M. T. Caldwell, S. Teahan, K. Al-Brekeit, A. Rasheed, A. Cullen, C. O’Keane, J. MacFarlane, M. Walsh, T. McGloughlin, P. Grace, D. Colgan, P. Madhavan, S. Sultan, M. P. Colgan, D. Moore, G. Shanik, N. McEniff, M. Molloy, E. Eguare, C. Fiuza, P. Burke, R. Maher, M. Creamer, C. J. Cronin, H. H. Sigurdsso, W. Kim, G. Linklater, K. S. Cross, W. G. Simpson, J. A. M. Shaw, D. W. M. Pearson, P. Fitzgerald, P. Quinn, C. M. Brady, S. M. A. Shah, M. Ehtisham, M. S. Khan, H. D. Flood, M. Loubani, K. Sweeney, B. Lenehan, V. Lynch, A. Joy, D. Reidy, K. Mahalingam, W. Cashman, E. D. Mulligan, T. Purcell, B. Dunne, M. Griffin, N. Noonan, D. Hollywood, N. Keeling, J. V. Reynolds, T. P. J. Hennessy, D. O’Halloran, P. Neary, D. Hamilton, N. Haider, N. Aherne, R. G. K. Watson, D. Walsh, M. Murphy, M. Joyce, S. Johnston, O. Clinton, H. F. Given, A. Brannigan, M. O’Donohoe, J. Donohoe, T. Corrigan, M. Bresnihan, T. M. Feeley, M. P. McMonagle, D. Quinlan, D. Kelly, P. K. Hegarty, B. Tan, C. Cronin, M. P. Brady, M. Zeeshan, D. J. McAvinchey, C. Mooney, D. Coyle, G. Khayyat, E. Masterson, T. Thambi-Pillai, K. Farah, M. B. Codd, G. G. Tsiotos, C. D. Johnson, M. G. Sarr, M. R. Kell, M. Lynch, D. Ryan, A. O’Donovan, M. Cassidy, M. Doyle, G. Fulton, P. R. O’Connell, R. Kingston, M. Dillon, E. McDermott, N. O’Higgins, R. G. O’Sullivan, and J. A. O’Donnell
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business.industry ,Foundation (engineering) ,Medicine ,Library science ,General Medicine ,business - Published
- 1998
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10. National scientific medical meeting 1997 abstracts
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H. J. Willison, A. J. Lastovica, M. M. Prendergast, A. P. Moran, C. Walsh, I. Flitcroft, P. Eustace, C. McMahon, J. Smith, O. P. Smith, G. Lakshmandass, M. R. H. Taylor, C. V. Holland, D. Cox, B. Good, G. M. Kearns, P. Gaffney, K. Shark, M. Frauenshuh, W. Ortmann, R. Messner, R. King, S. Rich, T. Behrens, N. Mahmud, A. Molloy, J. McPartlin, J. M. Scott, D. G. Weir, K. M. Walsh, D. Thorburn, P. Mills, A. J. Morris, T. Good, S. Cameron, E. A. B. McCruden, M. W. Bennett, J. O’Connell, C. Brady, D. Roche, J. K. Collins, F. Shanahan, G. C. O’Sullivant, M. Henry, S. Koston, K. McMahon, W. MacNee, M. X. FitzGerald, C. M. O’Connor, D. McGonagle, W. Gibbon, P. O’Connor, P. Emery, M. Murphy, R. Watson, E. Casey, E. Naidu, L. Barnes, S. McCann, E. Sweeney, E. J. Barrett, H. Graham, R. T. Cunningham, C. F. Johnston, W. J. Curry, K. D. Buchanan, C. H. Courtney, A. S. McAllister, D. R. McCance, D. R. Hadden, P. M. Bell, H. Leslie, B. Sheridan, A. B. Atkinson, M. T. Kilbane, D. F. Smith, M. J. Murray, S. G. Shering, E. W. M. McDermott, N. J. O’Higgins, P. P. A. Smyth, J. McEneny, E. R. Trimble, I. S. Young, P. Sharpe, C. Mercer, D. McMaster, A. E. Evans, J. Cundick, O. Hasselwander, J. McGeough, D. Savage, A. P. Maxwell, F. Kee, C. J. Larkin, R. G. P. Watson, C. Johnston, J. E. S. Ardill, D. A. McNamara, T. N. Walsh, D. J. Bouchier-Hayes, C. Madden, C. Timon, N. Gardiner, M. Lawler, J. O’Riordan, C. Duggan, S. R. McCann, H. Gowing, E. Braakman, C. Byrne, A. C. M. Martens, A. Hagenbeek, N. Kinsella, S. Cusack, H. Baker, B. White, K. Molloy, A. Wogan, S. McElwaine, D. Hollywood, C. Mcmahon, C. Merry, M. Ryan, O. Smith, F. M. Mulcahy, C. Murphy, J. Briones, P. Lavin, M. McCaffrey, P. Gillen, L. Thompson, M. Lalloz, M. Layton, C. Corish, N. P. Kennedy, P. Flood, S. Mulligan, E. McNamara, P. M. Mathias, E. Ball, D. Duiculescu, P. Calistru, N. O’Gorman, M. Abuzakouk, C. Feighery, M. Brannigan, S. Pender, F. Keeling, J. Varghese, M. Lee, M. Colreavy, R. Gaffney, S. Hone, M. Herzig, M. Walsh, C. Dolan, D. Donovan, J. Harmey, A. Haverty, J. H. Wang, J. H. Harmey, H. P. Redmond, G. McGreal, M. J. Moriarty, A. Shortt, E. Kay, G. Pidgeon, P. Dunne, H. Lambkin, J. M. Russell, A. J. O’Neill, B. M. Dunne, M. O’Donovan, E. F. Gaffney, J. E. Gillan, T. G. Cotter, J. Horan, D. Jones, S. K. Biswas, E. C. Mulkerrin, H. Brady, J. O’Donnell, J. Neary, E. Healy, A. Watson, B. Keogh, C. Cassidy, S. Ward, E. Stokes, F. Keoghan, A. Barrett, P. O’Connell, N. Ryall, P. A. O’Connell, A. Jenkinson, T. O’Brien, P. G. O’Connell, R. Harrison, T. Barrett, D. M. D. Bailey, A. Butler, D. E. Barton, G. Daly, M. Gill, S. Heron, Z. Hawi, M. Fitzgerald, L. Mynett-Johnson, D. Shiels, K. Kendler, P. McKeon, R. Straub, D. Walsh, F. Ryan, D. McCabe, R. Murphy, R. Segurado, T. Mulcahy, B. Larson, C. Comerford, R. O’Connell, E. O’Mahony, J. Donnelly, F. Minahan, D. O’Neill, Z. Farrell, C. Glynn, E. Mulkerrin, S. E. Lennox, A. Murphy, I. M. Rea, H. McNulty, C. McMeel, H. McEvoy, R. Freaney, M. J. McKenna, M. Crowe, D. Keating, G. Norman, S. Widda, L. Viani, null Galvin, C. M. Nolan, O. Hardiman, F. Brett, O. Droogan, P. Gallagher, M. Harmey, M. King, J. Murphy, R. Perryrnan, S. Sukumaran, J. Walsh, M. A. Farrell, G. Hughes, C. Cunningham, J. B. Walsh, D. Coakley, M. Hurson, P. McMonagle, S. O’Sullivan, P. Dodd, J. Redmond, R. Browne, S. Keating, J. O’Connor, B. P. Cassidy, R. Smyth, N. P. Sheppard, R. Cullivan, J. Crown, N. Walsh, A. Denihan, I. Bruce, A. Radic, B. A. Lawlor, P. K. Bridges, M. O’Doherty, A. Farrington, B. Farragher, S. Fahy, R. Kelly, T. Carey, J. Owens, O. Gallagher, D. Sloan, C. McDonough, P. Casey, A. Horgan, A. Elneihum, C. O’Neill, T. McMonagle, J. Quinn, D. Meagher, P. Murphy, A. Kinsella, J. Mullaney, J. L. Waddington, S. Rooney, L. Bamford, J. J. O’Connor, R. Franklin, K. O’Brien, G. Fitzpatrick, J. G. Laffey, J. F. Boylan, J. Laffey, M. Coleman, J. Boylan, A. J. McShane, J. P. R. Loughrey, J. Gardiner, J. McGinley, I. Leonard, M. Carey, P. Neligan, J. O’Rourke, A. Cunningham, F. Fennessy, C. Kelly, D. Bouchier-Hayes, J. Kellett, D. Murphy, J. Regan, D. O’Keeffe, A. Mahmud, L. Hemeryck, J. Feely, M. Hall, I. B. A. Menown, T. P. Mathew, G. S. Nesbitt, M. Syme, A. A. J. Adgey, F. Turtle, J. Allen, J. Anderson, R. O’Hanlon, M. B. Codd, S. Walkin, H. A. McCann, D. D. Sugrue, A. M. Rasheed, G. Chen, A. Leahy, S. Jina, I. McDowell, Q. Wo, M. N. Shuhaibar, E. McGovern, G. Manoharan, R. Kirkpatrick, N. P. S. Campbell, C. McCarthy, Y. Wen, S. Killalea, C. J. Fahy, A. Griffith, A. Fraser, T. Ryan, M. Browne, J. Fenton, J. Hughes, C. I. Timon, A. Curran, D. Smyth, J. P. Hughes, P. Lee, A. Kelly, N. Shine, A. Blayney, D. P. McShane, J. Hussey, M. Howlett, A. Langton, A. McEvoy, J. Slevin, C. Fitzpatrick, M. J. Turner, F. Enright, N. Goggin, C. Costigan, D. Duff, P. Osizlok, F. Wood, R. B. Fitzsimons, N. Flanagan, E. Molloy, E. Griffin, P. F. Deasy, M. Sheridan, M. J. White, R. Moore, A. Gray, J. Hill, J. F. T. Glasgow, B. Middleton, D. Slattery, V. Donoghue, A. McMahon, A. McCarthy, P. Oslislok, I. Keogh, K. J. Russell, M. X. Fitzgerald, P. V. Kavanagh, S. M. McNamara, M. Barry, J. E. O’Brien, P. McCormick, C. Molony, R. M. Doyle, P. R. O’Connell, L. C. Dowey, H. McGlynn, D. I. Thurnham, S. J. Elborn, L. Flynn, J. Carton, B. Byrne, C. O’Farrelly, P. Kelehan, C. O’Herlihy, A. M. O’Hara, A. Orren, B. A. Fernie, S. Clarke, G. Courtney, C. de Gascun, M. Byrne, E. Moylett, H. Murphy, K. Butler, C. Nourse, H. Thaker, C. Barry, J. Russell, G. Sheehan, B. Boyle, R. Hone, B. Conboy, C. Butler, D. Moris, M. Cormican, J. Flynn, O. McCormack, N. Corbally, A. Murray, S. Kirrane, C. O’Keane, S. M. Lynch, B. Cryan, D. Whyte, D. Morris, G. Corbett-Feeney, T. Mackle, J. Perkins, C. Saidlear, A. Young, M. Wrigley, J. Clifford, O. Tighe, D. T. Croke, J. Drago, D. R. Sibley, M. Carvalho, M. Hennessy, M. Kelly, C. Hughes, M. Hanlon, K. Sabra, T. Keane, D. Egan, C. Maerry, S. C. Sharma, D. Williams, N. G. Mahon, G. M. Sayers, and Z. Johnson
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Medical education ,business.industry ,Medicine ,General Medicine ,business - Published
- 1998
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11. Sylvester o’halloran surgical scientific meeting
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G. J. Fulton, M. G. Davies, P. O’Hagen, A. Rasheed, C. Kelly, E. Kay, S. Fitzgerald, D. Bouchier-Hayes, A. Leahy, F. Fennessy, P. Fitzgerald, K. Khosraviani, H. P. Weir, K. Williamson, R. Wilson, R. J. Moorehead, B. J. Rowlands, D. Morrissey, J. O’Connell, D. Lynch, C. O’Sullivan, F. Shanahan, J. K. Collins, J. L. Kelly, C. C. Soberg, A. Lyons, J. A. Mannick, J. A. Lederer, C. Chen, D. J. Bouchier-Hayes, H. Fitzsimons, D. M. O’Hanlon, C. Curran, M. Canney, S. Morris, O. Clinton, H. F. Given, E. Coveney, H. K. Lyerly, F. L. Murphy, C. J. Kelly, D. H. Osborne, P. Kelly, D. S. O’Riordan, P. G. Horgan, F. B. V. Keane, W. A. Tanner, P. Kilmartin, C. P. Delaney, S. M. Johnston, J. M. Fitzpatrick, T. F. Gorey, J. Mehigan, M. G. O/rsRiordan, N. Shines, A. Hill, C. O. McDonnell, F. Murphy, S. M. Javadpour, Y. Alhadi, R. Waldron, R. G. Watson, A. Tarrant, T. K. Neelamekam, J. Mathias, J. Geoghegan, T. Boyle, O. Traynor, S. Hayes, B. O’Donovan, N. Ajmal, J. McCann, N. T. Corrigan, M. G. O’Riordan, P. Ross, M. O’Donohoe, M. Bresnihan, T. M. Feeley, C. Fiuza-Castineira, D. Coleman, H. Fisher, A. Butt, E. Ghumman, P. Grace, P. Burke, S. A. Martin, M. K. Fox-Talbot, P. A. Lipsett, K. D. Lillemoe, H. A. Pitt, D. A. O’Keeffe, A. D. K. Hill, K. Sheahan, F. Ryan, D. Barton, R. Fitzgerald, E. W. McDermott, N. J. O’Higgins, E. Kavanagh, P. Kiely, D. O’Driscoll, M. Ramesh, W. O. Kirwan, D. C. Winter, K. Nally, J. O’Callaghan, J. B. Matthews, B. J. Harvey, G. C. O’Sullivan, L. S. Young, M. C. Regan, P. Sweeney, D. M. Bouchier-Hayes, R. Dardis, P. Broe, M. G. O’Brien, P. Neary, P. Ridgeway, C. Condron, J. H. Wang, H. P. Redmond, D. R. M. Redfern, R. K. S. Strachan, J. M. Hollingdale, P. A. Grace, A. Acheson, A. Graham, C. Weir, B. Lee, C. O’Donnell, D. Buckley, J. A. O’Donnell, E. Purcell, M. O’Donoghue, S. Sultan, M. Colgan, M. Molloy, D. Moore, G. Shanik, P. T. McCollum, Z. Raza, S. Naidu, P. A. Stonebridge, M. P. Colgan, D. J. Moore, D. G. Shanik, J. Dowdall, C. Williams, S. G. Shering, G. Duffy, R. Greengrass, D. Iglehart, G. Little, H. Kim Lyerly, M. Fynes, A. Cahill, C. O’Herlihy, P. R. O’Connell, I. Ahmad, M. Etisham, J. Drumm, H. Flood, K. Mulhall, K. Murray, S. O’Rian, N. Garvey, J. Johnston, G. T. McGreal, M. P. Brady, M. M. Duffy, M. Regan, M. G. Harrington, M. Javadpour, C. McDonnell, E. Eguare, M. C. Barry, G. C. O’Toole, N. O’Higgins, E. McDermott, C. M. Brady, S. A. Sultan, M. K. O’Donoghue, M. P. Molloy, G. D. Shanik, R. J. Holdsworth, M. Fehily, C. Doran, F. Keane, J. F. Rothwell, M. J. Staunton, L. O’Mahony, E. F. Gaffney, K. Mealy, T. P. J. Hennessy, and J. Geibel
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business.industry ,Art history ,Medicine ,General Medicine ,business - Published
- 1998
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12. Irish endocrine society
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A. Gleeson, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, D. M. Sexton, G. Creedon, M. Ledwith, M. Griffin, N. O’Meara, P. B. Collins, M. T. Kilbane, A. M. Tuite, S. G. Shering, D. F. Smith, F. W. M. McDermott, N. J. O’Higgins, P. P. A. Smyth, K. McKenna, C. J. Thompson, W. M. Kohler, D. O’Shea, J. Alaghband-Zadeh, K. Latham, G. Carter, E. W. M. McDermott, S. L. Lovell, H. Leslie, C. Doherty, D. R. Hadden, Mary G. McGeown, B. T. Kinsley, T. J. McKenna, P. M. Byrne, C. Gallagher, M. J. McKennal, S. W. Li Voon Chong, C. Darby, P. Freyne, M. J. Cullen, E. McKone, A. Heffernan, D. A. Darko, E. Kyrialcides, R. Burr, V. L. Armstrong, C. N. Ennis, S. J. Hunter, B. Sheridan, A. B. Atkinson, P. M. Bell, L. Giblin, M. E. Griffin, B. Otridge, N. M. O’Meara, K. Weinger, M. Bajaj, C. J. Levy, M. Waters, D. C. Simonson, D. J. Cox, A. M. Jacobson, A. I. Traub, D. Sexton, M. I. Wiggam, A. E. Walmsley, A. C. Leary, G. Grealy, T. M. Higgins, N. Buckley, D. G. Barry, D. Murphy, J. B. Ferriss, E. M. McConnell, R. McCance, K. Nikookam, M. E. Suliman, M. Carroll, J. Webster, R. M. Wilson, D. R. Cullen, A. S. McAllister, D. R. McCance, Z. Alavi, J. A. O’Hare, G. D. Johnston, M. J. McKenna, and R. Freaney
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Irish ,business.industry ,language ,Endocrine system ,Medicine ,Library science ,General Medicine ,business ,language.human_language - Published
- 1998
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13. Waterford surgical October club and surgical section, Royal Academy of Medicine Joint Surgical Symposium
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F. J. Shannon, T. J. Boyle, D. C. Grant, O. J. Clyne, J. M. P. Hyland, E. D. Mulligan, T. Purcell, P. Lawlor, J. V. Reynolds, P. J. Byrne, T. P. J. Hennessy, M. Duff, A. D. K. Hill, S. G. Shering, E. W. McDermott, N. J. O’Higgins, M. Harte, J. Corrigan, S. Khurana, F. Manning, B. Kierce, M. Corbally, D. A. McNamara, E. Dimitriadis, E. Kay, H. P. Redmond, J. Harmey, D. J. Bouchier-Hayes, G. Chen, C. Kelly, H. Chen, A. Leahy, J. Bouchier-Hayes, D. C. Winter, K. Nally, J. O’Callaghan, B. J. Harvey, F. Shanahan, G. C. O’Sullivan, H. Wang, Q. D. Wu, C. Condron, and D. Bouchier-Hayes
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medicine.medical_specialty ,business.industry ,General surgery ,Medicine ,Joint (building) ,General Medicine ,Club ,business ,Surgical section ,Surgery - Published
- 1998
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14. Hereditary breast cancer
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Enda W. McDermott, J. M. Doyle, N. J. O’Higgins, and A. D. K. Hill
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education.field_of_study ,Pathology ,medicine.medical_specialty ,biology ,business.industry ,Population ,Cancer ,Disease ,medicine.disease ,Bioinformatics ,Breast cancer ,biology.protein ,Genetic predisposition ,Presymptomatic Testing ,Medicine ,PTEN ,Mutation frequency ,skin and connective tissue diseases ,business ,education - Abstract
Genetic predisposition is responsible for 5–10% of all breast cancer, and a much larger percent of early-onset disease. Within the past few years, a number of genes associated with a high risk of breast cancer have been identified, including BRCA1, BRCA2, p53, and the Cowden disease gene PTEN/MMAC1. These genes appear to function as tumor suppressors, and although their mutation frequency in the general population is low, certain populations have a carrier frequency of up to 1% for particular BRCA1 and BRCA2 mutations. The isolation of these genes is likely to provide important insight into the pathogenesis of human cancer. The clinical application of these molecular discoveries raises controversial issues regarding presymptomatic testing for patients suspected of harboring cancer predisposing mutations.
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- 1997
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15. A direct relationship between thyroid enlargement and breast cancer
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D. F. Smith, J G Geraghty, M. J. Murray, P. P. A. Smyth, Enda W. McDermott, and N. J. O’Higgins
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Adult ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Mammary gland ,Thyroid Gland ,Breast Neoplasms ,Thyroid Function Tests ,Biochemistry ,Thyroid function tests ,Breast Diseases ,Endocrinology ,Breast cancer ,Internal medicine ,Prevalence ,Humans ,Medicine ,Prospective Studies ,Risk factor ,Prospective cohort study ,Aged ,Retrospective Studies ,Ultrasonography ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Biochemistry (medical) ,Thyroid ,Middle Aged ,Hyperplasia ,medicine.disease ,Thyroid Diseases ,medicine.anatomical_structure ,Female ,Breast disease ,business ,Iodine - Abstract
Despite extensive study, evidence to support a direct relationship between diseases of the thyroid and breast has not been established. In this study thyroid volume was assessed by ultrasound in 200 patients with breast cancer and 354 with benign breast disease. Results were compared to appropriate female control groups. Both mean thyroid volume (21.1 +/- 1.4 mL) and the percentage of individual patients with enlarged (> 18.0 mL) thyroid glands (41.5%) were significantly greater in the breast cancer group than equivalent values (13.2 +/- 0.5 mL and 10.5%, respectively) in age-matched controls (P < 0.01 in both cases). The mean thyroid volume of 14.5 +/- 0.34 mL in patients with benign breast disease was also significantly greater than that of 12.5 +/- 0.38 mL in younger controls (P < 0.01). The results support a direct association between breast cancer and increased thyroid volume as mean thyroid volumes and the percentage of individual patients with enlarged thyroid glands were similar in those studied both before (20.8 +/- 1.3 mL and 43.0%) and after (21.4 +/- 1.6 mL and 40.0%) therapies for breast cancer. Although there is no evidence that thyroid enlargement represents a risk factor for breast cancer, the results emphasize the importance of raising the consciousness of the coincidence of both disorders.
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- 1996
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16. Irish endocrine society
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U. Fearon, D. Clarke, T. J. McKenna, S. K. Cunningham, P. J. Morrison, A. E. Hughes, N. C. Nevin, C. F. J. Russell, D. Powell, D. R. Hadden, B. D. Bonar, D. F. Smith, C. Darke, A. M. Hetherton, P. P. A. Smyth, S. J. Hunter, R. Harper, C. N. Ennis, E. Crothers, B. Sheridan, A. B. Atkinson, P. M. Bell, F. Hayes, K. Sheahan, M. McCabe, D. J. Conway, N. J. O’Higgins, P. Garry, J. Laski, L. Brosnan, P. Collins, J. G. Devlin, A. P. Heaney, W. J Curry, C. F. Johnston, K. D. Buchanan, M. Mirakhur, T. M. Fiad, M. Culliton, J. A. Lynn, D. B. O’Shea, M. K. Meeran, J. A. Jackson, S. R. Bloom, K. Sheehan, A. Heffernan, A. G. Nugent, C. McGurk, R. Rutherford, J. R. Hayes, G. D. Johnson, Y. A. Cusack, D. O’Riordan, E. W. M. McDermott, E. F. Roche, I. McCormack, E. T. Tempany, D. S. Smith, P. Deegan, D. Owens, S. Gilligan, A. Johnson, G. H. Tomkin, A. Heaney, C. Ennis, M. I. Wiggam, M. J. O’Kane, E. R. Trimble, F. P. Dunne, D. A. Heath, T. Rollason, W. A. Ratcliffe, T. Marshall, C. C. Cronin, D. G. Barry, B. Crowley, J. B. Ferriss, B. T. Kinsley, D. C. Simonson, R. Jones, P. D. Lambert, J. Herbert, J. A. O’Hare, F. Abuaisha, Q. Razza, M. Geoghegan, and E. Barrett
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medicine.medical_specialty ,Irish ,business.industry ,Family medicine ,Ophthalmology ,language ,Medicine ,Endocrine system ,General Medicine ,business ,language.human_language - Published
- 1995
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17. Irish Association for Cancer Research
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M. Lawler, A. Locasciulli, A. Bacigalupo, P. Humphries, P. Ljungman, S. R. McCann, N. Nolan, E. W. McDermott, J. R. Reynolds, A. McCann, R. Rafferty, P. Sweeney, D. Carney, N. J. O’Higgins, M. J. Duffy, C. Gardiner, D. J. Reen, M. A. O’Connell, D. Kelleher, N. Hall, L. A. J. O’Neill, A. Long, J. V. McCarthy, R. S. Fernandes, T. G. Cotter, E. Ryan, A. Kitching, P. MacMathuna, E. Mulligan, R. Merriman, P. Dervan, P. Kelly, T. F. Gorey, J. R. Lennon, J. Crowe, M. A. Bennett, E. W. Kay, B. Curran, D. P. O’Donoghue, M. Leader, D. T. Croke, J. M. O’Connor, V. J. McKelvey-Martin, P. G. McKenna, J. M. O’Riordan, A. Tobin, M. O’Mahoney, F. M. Keogh, J. O’Riordan, C. McNamara, P. McEneaney, P. A. Daly, M. Farrell, S. Young, D. Gibbons, P. McCarthy, H. Mulcahy, N. A. Parfrey, K. Sheahan, H. Lambkin, C. Mothersill, D. Chin, K. Sheehan, P. Kelehan, N. Parfrey, M. Morrin, F. Khan, P. Delaney, D. M. Rowan, W. J. Orminston, P. P. Donnellan, A. Khalid, M. Kerin, D. M. O’Hanlon, P. Kent, H. F. Given, S. M. Kennedy, G. McGeoch, N. K. Spurr, J. Barrett, G. O’Sullivan, J. K. Collins, T. Willcocks, S. Kennedy, J. Dolan, W. Gallagher, E. McDermott, N. O’Higgins, R. Hagan, R. McManus, W. Ormiston, P. Daly, O. Sheils, M. McDermott, D. S. O’Briain, D. Maher, P. Costello, F. Flanagan, J. Stack, J. Ennis, H. Grimes, A. Yanni, M. Harrison, W. S. Lowry, S. E. H. Russell, R. J. Atkinson, P. White, I. Hickey, D. W. Bell, D. Biggart, J. Doyle, M. J. Staunton, E. F. Gaffney, P. A. Dervan, M. M. McCabe, J. J. Fennelly, D. N. Carney, M. O’Reilly, J. N. McMahon, M. Moriarty, B. Hurson, A. J. O’Neill, H. Magee, J. O’Loughlin, P. Cremin, W. Orminston, J. McCarthy, P. Redmond, S. Duggan, S. Rea, D. Bouchier-Hayes, J. O’Donnell, C. Duggan, J. Crown, D. Bermingham, A. Nugent, C. Fleming, P. Crosby, S. Wolff, D. McCarthy, C. Barry Walsh, M. Cassidy, S. Husain, E. Kay, M. Thornhilll, D. Whelan, D. Barry, M. Turner, W. Prenderville, F. Murphy, W. Prendiville, G. Gibson, T. O’Grady, M. Carmody, J. Donohoe, J. Walshe, G. M. Murphy, J. O’Donoghue, K. Kerin, S. Ahern, K. Molloy, N. Goulden, D. H. Pamphilon, M. O’Connell, C. Power, A. Leroux, M. Perricaudet, D. Walls, F. Britton, L. Brennan, Y. A. Barnett, B. Madden, L. P. G. Wakelin, H. C. Loughrey, P. Corley, H. P. Redmond, R. W. G. Watson, I. Keogh, D. O’Hanlon, S. Walsh, J. Callaghan, M. McNamara, A. Benedict-Smith, C. Barnes, D. Neylon, M. Fenton, M. Searcey, C. M. Topham, L. G. Wakelin, N. M. Howarth, A. Purohit, M. J. Reed, B. V. L. Potter, W. J. Hatton, G. McKerr, D. Harvey, J. Carson, B. M. Hannigan, P. J. McCarthy, S. McClean, B. T. Hill, C. Costelloe, W. A. Denny, B. Fingleton, S. McDonnell, M. Butler, N. Corbally, J. F. Stephens, G. Martin, A. McGirl, E. Lawlor, N. Gardiner, S. Lynch, M. de Arce, F. O’Brien, A. Duggan, S. O’Herlihy, F. Shanahan, G. O’Keeffe, S. McCann, K. Sweeney, A. O. Neill, D. Pamphilon, M. Sheridan, I. Reid, C. B. Seymour, T. Walshe, T. P. Hennessy, A. O’Mahony, J. O’Connell’, C. Lawlor, S. Nolan, D. Morrisey, P. J. Pedlow, M. Walsh, S. W. Lowry, J. J. A. McAleer, S. R. McKeown, M. Afrasiabi, T. R. J. Lappin, B. Joiner, K. V. Hirst, D. G. Hirst, E. Sweeney, J. VanderSpek, J. Murphy, and F. Foss
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medicine.medical_specialty ,Irish ,business.industry ,Association (object-oriented programming) ,Family medicine ,medicine ,language ,General Medicine ,business ,language.human_language - Published
- 1995
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18. Sir Peter Freyer Memorial Lecture and Surgical Symposium 15th and 16th September, 1995
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J. Calleary, C. Tansey, J. McCormack, S. Kapur, J. Doyle, J. Flynn, A. J. Curran, D. Smyth, B. Kane, M. Toner, C. V. I. Timon, K. J. Cronin, J. O’Donoghue, F. X. Darmanin, J. McCann, F. Campbell, H. P. Redmond, C. Condron, D. Bouchier-Hayes, K. Aizaz, S. W. MacGowan, A. F. O’Donnell, D. A. Luke, E. McGovern, M. Morrin, F. Khan, P. V. Delaney, S. M. Lavelle, B. Kanagaratnam, V. Cuervas-Mons, A. Gauthier, C. Gips, R. Marques dos Santos, G. P. Molino, A. Theodossi, D. D. Tsiftsis, C. J. O. Boyle, T. J. Boyle, M. J. Kerin, D. M. Courtney, D. S. Quill, H. F. Given, D. F. O’Brien, E. J. Kelly, J. Kelly, D. Richardson, N. F. Fanning, R. Brennan, P. G. Horgan, F. B. V. Keane, S. Reid, C. Walsh, R. Patock, J. Hall, D. Evoy, M. Magd-Eldin, D. Curran, P. Keeling, N. Ade-Ajayi, L. Spitz, E. Kiely, D. Drake, N. Klein, D. M. O’Hanlon, D. Karat, K. Callanan, W. Crisp, S. M. Griffin, P. M. Murchan, B. Mancey-Jones, P. Sedman, C. J. Mitchell, J. Macfie, D. Scott, S. Raimes, C. J. O’Boyle, D. Maher, P. C. Willsher, J. F. R. Robertson, M. Hilaly, R. W. Blarney, S. G. Shering, S. Mitrovic, A. Rahim, E. W. McDermott, N. J. O’Higgins, C. A. Murphy, D. Morgan, C. W. Elston, I. O. Ellis, M. P. O’Sullivan, M. G. O’Riordain, J. P. Stack, M. K. Barry, J. T. Ennis, J. M. Fitzpatrick, T. F. Gorey, J. Kollis, H. Mullet, D. F. Smith, A. Zbar, M. J. Murray, E. W. M. McDermott, P. P. A. Smyth, N. Kapucouglu, S. Holmes, P. Holland, P. T. McCollum, A. da Silva, L. de Cossart, D. Hamilton, C. J. Kelly, K. Stokes, P. Broe, J. Crinnion, P. A. Grace, N. Morton, N. Ross, S. Naidu, P. Gervaz, R. J. Holdsworth, P. A. Stonebridge, A. O’Donnell, K. Carson, D. Phelan, S. McBrinn, D. McCarthy, H. Javadpour, J. McCarthy, M. Neligan, M. T. P. Caldwell, J. P. McGrath, P. J. Byrne, T. N. Walsh, P. Lawlor, C. Timon, R. C. Stuart, K. Murray, A. Carney, J. G. Johnston, B. Egan, P. R. O’Connell, J. Donoghue, A. Pollock, D. Hyde, D. Hourihan, W. A. Tanner, J. Donohue, N. Fanning, P. Horgan, A. Mahmood, K. Dave, J. Stewart, A. Cole, R. Hartley, T. G. Brennan, J. M. O’Donoghue, S. T. O’Sullivan, E. Beausang, J. Panchal, M. O’Shaughnessy, P. O’Grady, R. W. G. Watson, D. Johnstone, J. O’Donnell, E. McCarthy, N. Flynn, T. O’Dwyer, C. Curran, S. Duggan, S. Tierney, Z. Qian, P. A. Lipsett, H. A. Pitt, K. D. Lillemoe, J. Kollias, D. A. L. Morgan, I. S. Young, M. C. Regan, J. G. Geraghty, C. B. O. Suilleabhain, M. L. Rodrick, A. F. Horgan, J. A. Mannick, J. A. Lederer, T. P. J. Hennessy, M. Canney, K. Feeley, C. E. Connolly, H. Abdih, N. Finnegan, M. Da Costa, M. Shafii, A. J. Martin, D. Mulcahy, M. Dolan, M. Stephens, F. McManus, M. Walsh, D. P. O’Brien, J. P. Phillips, T. A. Carroll, D. O’Brien, D. Rawluk, T. Sullivan, K. Herbert, M. Kerins, M. O’Donnell, D. Lawlor, M. McHugh, G. Edwards, J. Rice, J. P. McCabe, J. Sparkes, S. Hayes, M. Corcoran, H. Bredin, D. O’Keeffe, J. Candon, E. D. Mulligan, T. H. Lynch, D. Mulvin, L. Vingers, J. M. Smith, H. Corby, K. Barry, I. Eardley, J. Frick, B. Goldwasser, P. Wiklund, E. Rogers, R. Weaver, P. T. Scardino, R. Kumar, P. Puri, A. B. Adeyoju, T. Lynch, J. Corr, T. E. D. McDermott, R. Grainger, J. Thornhill, M. Butler, D. Keegan, N. Hegarty, P. McCarthy, A. H. Mirza, M. O’Sullivan, P. Neary, T. P. F. O’Connor, D. McCormack, K. Cunningham, N. Cassidy, K. Mulhall, M. Murphy, A. Puri, B. Dhaif, P. D. Carey, R. J. Delicata, F. Abbasakoor, R. B. Stephens, A. J. Hussey, B. Garrihy, D. J. Nolan, O. J. McAnena, R. Fitzgerald, D. Watson, B. J. Coventry, P. Malycha, S. C. Ward, S. P. Y. Kwok, W. Y. Lau, J. W. Bergman, G. E. B. Hacking, C. Metreweli, A. K. C. Li, P. Madhavan, J. Donohoe, M. O’Donohue, D. A. McNamara, and M. K. O’Donohoe
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business.industry ,Medicine ,General Medicine ,business ,Classics - Published
- 1995
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19. National scientific medical meeting 1995 abstracts
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S. Norris, C. Collins, J. Hegarty, C. O’Farrelly, J. Carton, L. Madrigal, D. P. O’Donoghue, H. Holloway, J. F. Fielding, W. Mullins, S. W. Hone, M. Donnelly, F. Powell, A. W. Blayney, E. A. Cahill, S. F. Daly, M. J. Turner, P. A. Sullivan, M. McLoughlin, M. M. Skelly, H. E. Mulcahy, T. Connell, C. Duggan, M. J. Duffy, A. Troy, K. Sheahan, A. Whelan, C. M. Herra, C. T. Keane, H. Johnson, B. Lee, E. Doherty, T. McDonnell, D. Mulherin, O. FitzGerald, B. Bresnihan, H. M. Hassett, A. Boyce, V. Greig, C. O’Herlihy, P. P. A. Smyth, E. F. Roche, I. McCormack, E. Tempany, M. J. Cullen, D. F. Smith, Y. McBrinn, B. Murray, R. Freaney, D. Keating, M. J. McKenna, J. A. O’Hare, H. Alam, Q. Raza, M. Geoghegan, S. Killalea, M. Hall, J. Feely, L. Kyne, B. O’Hara, M. Cullen, I. M. Rea, J. P. Donnelly, R. W. Stout, P. Lacey, M. J. Donnelly, J. McGrath, T. P. Hennessy, C. V. I. Timon, D. Hyde, H. X. Xia, M. Buckley, C. O’Morain, S. Keating, H. Xia, J. P. McGrath, R. C. Stuart, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, M. Duffy, M. Tubridy, J. Redmond, K. Monahan, R. P. Murphy, D. R. Headon, T. O’Gorman, F. M. O’Reilly, C. Darby, G. M. Murphy, A. Murphy, M. Codd, P. Dervan, D. Lawlor, S. O. Loughlin, N. Flanagan, R. Watson, L. Barnes, C. Kilgallen, E. Sweeney, A. Mynes, D. Mooney, I. Donoghue, O. Browne, J. A. Kirrane, D. McKenna, M. Young, E. O’Toole, S. O’Briain, U. Srinivasan, C. Feighery, N. Leonard, E. Jones, M. A. Moloney, D. G. Weir, M. Lawler, A. O’Neill, H. Gowing, D. Pamphilon, S. R. McCann, G. O’Toole, A. Orren, C. M. Seifer, D. C. Crowley, G. J. Sheehan, T. Deignan, J. Kelly, V. J. Tormey, J. Faul, C. Leonard, C. M. Burke, L. W. Poulter, S. Lynch, G. McEntee, O. Traynor, E. Barry, P. Costello, A. Keavney, R. Willoughby, C. O’Donnell, M. Cahill, A. Earley, P. Eustace, R. Osborne, C. Saidlear, B. Holmes, A. Early, A. P. Moran, A. Neisser, R. J. Polt, H. Bernheimer, M. Kainz, B. Schwerer, L. Gallagher, R. Firth, N. Kennedy, E. McGilloway, N. Tubridy, K. Shields, W. K. Cullen, M. J. Rowan, A. R. Moore, M. Rowan, D. Coakley, B. Lawlor, G. Swanwick, R. Al-Naeemi, R. Murphy, N. M. Codd, M. Goggins, N. P. Kennedy, B. L. Mallon, H. Mulcahy, M. Skelly, D. O. Donoghue, D. McCarthy, A. Saunders, D. J. Veale, J. J. F. Belch, D. Breathnach, E. Murphy, G. Kernohan, K. Gibson, A. G. Wilson, G. W. Duff, N. de Vries, L. B. A. van de Putte, J. Donoghue, F. O’Kelly, Z. Johnson, T. Maher, A. Moran, C. Keane, D. O’Neill, N. Horgan, J. M. Barragry, D. M. Campbell, M. Behan, P. R. O’Connell, V. S. Donnelly, D. Crowley, M. Geary, P. Boylan, M. Fanagan, K. Hickey, T. Teoh, M. Doyle, R. Harrison, D. Lyons, Y. Shenouda, M. Coughlan, P. McKenna, P. Lenehan, M. Foley, P. Kelehan, P. Ravichandran, M. Kelly, A. Conroy, C. Fitzpatrick, D. Egan, C. L. Regan, B. V. McAdam, P. McParland, G. A. FitzGerald, D. J. Fitzgerald, S. C. Sharma, K. Foran, C. Barry-Kinsella, R. F. Harrison, F. J. Gillespie, P. O’Mahony, M. Boyle, M. J. White, F. Donohoe, Y. Birrane, M. Naughton, R. B. Fitzsimons, M. Piracha, S. McConkey, E. Griffin, E. Hayes, T. Clarke, N. Parfrey, K. Butler, A. J. Malone, P. J. Kearney, P. F. Duggan, A. Lane, R. Keville, M. Turner, S. Barry, D. Sloan, S. Gallagher, M. Darby, P. Galligan, J. Stack, N. Walsh, M. O’Sullivan, M. Fitzgerald, D. Meagher, S. Browne, C. Larkin, P. Casey, E. O’Callaghan, S. Rooney, E. Walsh, M. Morris, T. Burke, M. Roe, C. Maher, M. Wrigley, M. Gill, M. Burgess, E. Corcoran, D. Walsh, B. Gilmer, C. B. Hayes, L. Thornton, J. Fogarty, R. Lyons, M. O’Connor, V. Delaney, K. Buckley, D. Lillis, V. Delany, C. Hayes, P. Dack, D. Igoe, H. J. O’Neill, P. Kelly, D. McKeown, L. Clancy, G. Varghese, S. Hennessy, J. J. Gilmartin, K. Birthistle, D. Carrington, H. Maguire, P. Atkinson, C. Foley-Nolan, M. Lynch, B. Cryan, D. Whyte, C. Conlon, V. Kucinskas, U. Usinskiene, I. Sakalyte, E. Dawson, K. Molloy, N. Goulden, J. Doyle, E. Lawlor, M. G. Harrington, N. El-Nageh, M. -L. Nolan, J. O’Riordan, G. Judge, G. Crotty, T. Finch, M. Borton, T. Barnes, O. Gilligan, G. Lee, R. Limmer, M. Madden, C. Bergin, A. O’Leary, F. Mulcahy, F. Wallis, M. Glennon, M. Cormican, U. NiRiain, M. Heiginbothom, F. Gannon, T. Smith, C. O’Sullivan, R. Hone, D. A. Caugant, C. A. P. Fijen, E. J. Van Schalkwyk, G. J. Coetzee, U. Ni Riain, M. G. Cormican, L. Park, J. Flynn, V. Regazzoli, M. Hayes, G. Nicholson, P. Higgins, N. Flynn, G. Corbett-Feeney, D. J. Conway, N. J. O’Higgins, S. Rajendiran, J. Byrne, E. Kilfeather, P. Dingle, M. Hunter, S. K. Al-Ghazal, P. Stanley, J. Palmer, A. Hong, P. Saxby, D. Sheehan, I. Regan, J. O’Mullane, M. Ni Chaoimh, M. Leahy, J. J. Heffron, M. Lehane, C. Keohane, N. O’Leary, M. Sheehan, E. Renny-Walsh, M. J. Whelton, C. T. Doyle, J. Webster, N. Benjamin, S. FitzGerald, J. S. Chadha, M. G. FitzGerald, G. R. FitzGerald, L. Hemeryck, P. McGettigan, J. Golden, N. Arthur, S. Y. Wen, P. Deegan, T. Cooke, G. I. Adebayo, P. Gaffney, M. Sinnot, D. O’Riordan, T. Hayes, C. M. O’Connor, M. X. FitzGerald, C. Costello, G. Finlay, J. Hayes, C. O’Connor, K. McMahon, S. Hone, J. Robertson, R. Coakley, S. O’Neill, M. Walsh, J. McCarthy, D. Lannon, A. E. Wood, R. Sharkey, E. Mulloy, M. Long, I. Kilgallen, V. Tormey, S. Horne, T. Feeney, Ó. Ó Muiré, M. J. Griffin, D. Hughes, A. Knaggs, D. Magee, C. McCrory, B. March, D. Phelan, M. White, J. Fabry, D. Buggy, C. Cooney, E. Aziz, D. O’Keefe, A. J. McShane, J. Boylan, E. Tobin, C. Motherway, F. Colreavy, N. Denish, R. Dwyer, A. Bergin, K. O’Brien, R. MacSullivan, K. D. Carson, W. P. Blunnie, D. C. Moriarty, B. Kinirons, B. Lyons, N. Cregg, W. Casey, K. P. Moore, S. A. Colbert, C. Ecoffey, D. O’Gorman, J. Fitzgerald, P. Diamond, M. B. Codd, D. D. Sugrue, J. Kellett, M. Tighe, C. J. McKenna, J. Galvin, H. A. McCann, A. Scallon, A. Fraser, M. Norton, G. Tomkin, I. Graham, A. Byrne, M. Maher, N. Moran, D. Fitzgerald, D. O’Callaghan, D. Coyle, A. G. Nugent, C. McGurk, G. D. Johnston, A. Nugent, B. Silke, N. Murphy, L. Jennings, D. Pratico, C. Doyle, T. Hennessy, H. McCann, D. Sugrue, S. Donnelly, A. Hennessy, C. Hartigan, D. MacDonald, S. Blake, D. McDonald, D. Dominque, S. R. McMechan, G. MacKenzie, J. Allen, G. T. Wright, G. J. Dempsey, M. Crawley, J. Anderson, A. A. J. Adgey, M. T. Harbinson, N. P. S. Campbell, C. M. Wilson, P. K. Ellis, E. M. McIlrath, A. McShane, T. V. Keaveny, K. Rabenstein, F. Scheller, D. Pfeiffer, C. Urban, I. Moser, G. Jobst, A. Manz, S. Verpoorte, F. Dempsey, D. Diamond, M. Smyth, E. Dempsey, V. Hamilton, J. Twomey, R. Crowley, L. Fenelon, F. Walsh, J. McCann, P. McDonagh, E. McGovern, D. Luke, K. Crowley, D. Mannion, D. Murphy, K. Clarkson, E. Carton, I. Leonard, D. O’Toole, M. Staunton, M. Griffin, D. Owens, P. Collins, A. Johnson, G. H. Tomkin, N. A. Herity, J. D. Allen, R. O’Moore, G. M. Crotty, M. DeArce, K. Nikookam, P. Keenan, D. Cregan, N. O’Meara, S. Forman, D. A. Cusack, and B. Farrell
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medicine.medical_specialty ,business.industry ,Family medicine ,medicine ,MEDLINE ,General Medicine ,business - Published
- 1995
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20. Urokinase plasminogen activator as a prognostic marker in different subgroups of patients with breast cancer
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Michael J. Duffy, Enda W. McDermott, N. J. O’Higgins, Peter A. Andreasen, James J. Fennelly, and D. Reilly
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Oncology ,Cancer Research ,medicine.medical_specialty ,Pathology ,Axillary lymph nodes ,business.industry ,Urokinase Plasminogen Activator ,Estrogen receptor ,Cancer ,medicine.disease ,Metastasis ,medicine.anatomical_structure ,Breast cancer ,Internal medicine ,medicine ,In patient ,business ,Survival analysis - Abstract
Background. Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. Previously, uPA was shown to be an independent prognostic marker in breast cancer. The aim of this study were to evaluate uPA as a prognostic marker in different subgroups of patients with breast cancer. Methods. Urokinase plasminogen activator was as sayed by enzyme-linked immunosorbent assay in detergent extracts of human breast tumors. Results. Using both disease free interval (DFI) and overall survival (OS) as end points, uPA was an indicator of prognosis in the following groups of patients: those with positive axillary nodes, those who were estrogen receptor (ER)-positive, women younger than 50 years of age, and women older than 50 years of age, For patients with negative axillary lymph nodes, uPA was a significant prognostic marker using DFI as an end point and was almost statistically significant (P = 0.055) using OS as end point. In patients who were ER-negative, uPA levels showed no significant relationship with patient outcome. Conclusions. Urokinase plasminogen activator is a significant prognostic marker in most of the major subgroups of patients with breast cancer and may be a marker for patients with negative axillary lymph nodes.
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- 1994
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21. 19th Sir peter freyer memorial lecture and surgical symposium 16th and 17th September 1994
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D. A. McEvoy, B. Connolly, V. Donohue, D. O’Halpin, H. Rowley, T. P. O’Dywer, C. Timon, J. A. McKeever, M. A. Stokes, J. G. Bannigan, M. J. Early, D. M. Baker, Van-Tam Nguyen, D. Bush, J. Jones, J. B. Bourke, K. S. Cross, G. Durkan, M. Stokes, T. Carroll, T. Gorey, K. O’Malley, D. Mulcahy, D. McCormack, J. McElwain, S. C. Natin, T. N. Walsh, T. P. J. Hennessy, K. Carson, R. Page, W. Blunnie, D. C. Moriarty, R. W. G. Watson, D. M. Bouchier-Hayes, H. Abdih, C. J. Kelly, M. Barry, P. Burke, A. Tanner, D. J. Bouchier-Hayes, T. O’Sullivan, A. F. Horgan, D. H. L. Chin, J. A. Mannick, M. L. Rodrick, N. Finnegan, S. T. O’Sullivan, S. F. Wolf, M. C. Barry, C. Condron, R. G. K. Watson, J. D. Evans, C. A. Maxwell-Armstrong, M. K. Barry, K. K. Singh, P. Ralston, C. D. Auld, M. Henderson, J. McCormick, A. D. F. Walls, I. Keogh, M. Kerin, D. O’Hanlon, S. Walsh, P. Kent, J. Callaghan, H. F. Given, P. Madhavan, B. Golden, F. Khan, E. Murphy, N. Couse, G. Burke, P. V. Delaney, R. McLoughlin, P. Kenny, D . O’Hanlon, H. Grimes, S. Reid, P. Neary, M. Nassralla, T. K. Neelamekam, P. Horgan, O. Traynor, P. G. Horgan, J. Hyland, D. M. O’Hanlon, C. O’Boyle, M. J. Duffy, E. W. M. McDermott, D. Reilly, J. J. Fennelly, N. J. O’Higgins, A. McNamara, H. Mullett, D. O’Riordan, E. McDermott, M. Sharp, N. O’Higgins, M. Murphy, M. Little, D. Maher, A. Khalid, P. McCarthy, I. F. Given, C. Bolger, J. P. Phillips, C. Gilligan, S. Zareb, C. Roake, D. S. O’Riordain, D. Farley, C. Grant, J. van Heerden, D. P. O’Brien, M. J. Flynn, F. B. V. Keane, B. Sweeney, D. O’Riordain, A. J. Curran, W. Joyce, D. Smith, H. Gallagher, M. A. Walsh, D. Bouchier-Hayes, J. Phillips, T. O’Brien, S. W. Yusuf, A. C. Perkins, M. Frier, P. W. Wenham, B. R. Hopkinson, G. S. Makin, R. Hind, W. Yusuf, S. C. Whitaker, R. E. Hind, T. A. M. Chuter, G. C. Durkan, M. J. Grenell, M. C. Regan, T. F. Gorey, C. F. Castineira, S. J. Sheehan, M. Wali, M. P. Colgan, D. J. Moore, G. D. Shanik, G. McGreal, J. Kelly, D. Hehir, M. P. Brady, D. M. Sibbering, P. A. M. Holland, A. R. M. Wilson, R. W. Blarney, M. Khurrum Baig, N. Mulligan, B. Farrell, F. O. Cunningham, M. Magd-Eldin, P. Keeling, Y. A. Gul, S. W. Yeo, U. D. Khan, F. Lennon, M. F. Shine, V. Kalidasan, O. Fulena, E. J. Guiney, R. J. Fitzgerald, M. Corbally, A. E. Wood, C. M. Reardon, G. T. McGreal, D. J. Hehir, J. A. O’Donnell, W. O. Kirwan, A. A. Mahomed, A. Keshgar, R. Surna, M. T. Corbally, S. O’Rourke, I. Beckingham, M. C. Bishop, J. Husain, N. Hegarty, J. Calleary, I. Rafi, M. Gilmore, S. M. Saleem, H. P. Singh, T. Aherne, H. P. Redmond, J. McCarthy, D. M. Mulcahy, P. Nicholson, P. Harrington, T. Sharif, H. Smyth, G. Fenelon, J. Pegum, J. Corrigan, A. Jenkinson, A. A. El-Magbri, M. A. Gussail, M. A. Smew, A. Martin, M. Bennett, M. A. Farrell, C. Curran, M. J. Kerin, M. T. P. Caldwell, P. J. Byrne, S. Duggan, A. S. Jones, J. K. Field, D. Monaghan, C. Condren, S. Crerand, M. Kavanagh, P. Dervan, B. Hurson, K. Aiyaswami, D. Evoy, M. Walsh, B. Garrihy, S. Kaf Al-Ghazal, J. O’Donoghue, J. McCann, S. Wagstaff, C. Conroy, M. Dolan, L. Smith, L. Klenerman, J. Noel, V. Waide, D. O’Sullivan, C. Biyani, C. Powell, M. Heal, R. Surana, A. Khan, T. Lynch, T. Sami, W. Baluch, D. Hickey, M. Donovan, P. McLean, D. Murphy, S. Johnston, V. Rastogi, J. Doyle, J. R. Flynn, P. Kelly, M. F. Neligan, S. W. MacGowan, O. Sharkey, A. Bhojwani, C. Barry Walsh, E. Kay, C. Milbum, M. Leader, J. McDermott, D. Moriarty, P. Caushaj, J. M. Fitzpatrick, D. Byrne, W. P. Hederman, N. K. O’Malley, K. H. Chan, P. Fleming, G. C. O’Sullivan, K. Aizaz, A. F. O’Donnell, D. A. Luke, E. M. McGovern, N. Patil, P. Gormley, and P. M. McCarthy
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medicine.medical_specialty ,business.industry ,medicine ,Physiology ,Medical physics ,General Medicine ,Session (computer science) ,business - Published
- 1994
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22. A season of football injuries
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R F McQuillan, Maurice Stokes, N. J. O’Higgins, and J A McKeever
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,business.industry ,Football ,Human factors and ergonomics ,Poison control ,General Medicine ,Emergency department ,Middle Aged ,Suicide prevention ,Occupational safety and health ,Soccer ,Injury prevention ,Physical therapy ,medicine ,Humans ,Prospective Studies ,Child ,business ,human activities ,Medical attention - Abstract
All rugby and soccer players presenting to the Accident & Emergency department during the football season 1992-1993 (a total of 871) were prospectively studied to compare the injuries sustained in the two sports. The nature and site of injury, treatment required, age, fitness, experience and position of the player, situation giving rise to injury, and medical attention at the grounds were all analysed. The results show that rugby and soccer players had the same number of injuries, and while there were some differences in the nature of the injuries, there was no difference in overall severity. Rugby flankers and soccer goalkeepers are particularly at risk. Competitive matches produce more injuries than training sessions. Experience or fitness did not appear to be a factor and 45% of rugby injuries and 15% of soccer injuries were from school matches. Law changes (e.g. the rugby scrum and the use of gum-shields) have reduced some injuries, but other areas (e.g. jumping for the ball in soccer, rucks and mauls in rugby) also warrant consideration. There was one death, but no spinal cord injuries. Medical attention at the grounds was limited. Rugby injuries, therefore, do not appear to be more numerous or severe than soccer injuries. Law changes have been of benefit but they need to be enforced and perhaps more should be considered. Medical attention at sports grounds could be improved and Registers of injuries kept by the sporting bodies would be of benefit.
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- 1994
- Full Text
- View/download PDF
23. Irish endocrine society
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E. Dimitriadis, D. Owens, P. Collins, A. Johnson, G. Tomkin, C. C. Cronin, D. Barry, B. Crowley, J. B. Ferriss, A. M. Hetherton, D. F. Smith, C. O’Herlihy, P. P. A. Smyth, T. M. Fiad, M. Culliton, J. Dunbar, S. K. Cunningham, T. J. McKenna, A. P. Heaney, G. L. Loughrey, D. R. McCance, E. Mcllrath, D. R. Hadden, L. Kennedy, B. Sheridan, J. B. Ferris, A. Whyte, P. E. Cleary, D. J. McAuley, B. Mathew, I. C. Bailey, A. Curtin, K. Lenehan, P. Deegan, M. Henry, M. Stapleton, H. Baker, P. F. Duggan, T. H. Mitchell, J. A. O’Hare, M. Geoghegan, F. Abuaisha, U. Fearon, D. Clarke, R. N. Roberts, A. I. Traub, W. Thompson, H. Whitehead, J. Holmes, R. Roberts, N. A. Al-Mandhari, A. Greer, D. Carson, T. Traub, D. Hadden, T. Ferguson, A. B. Atkinson, S. O’Keeffe, J. G. Devlin, C. Donnellan, C. R. Russell, T. L. Kennedy, A. L. Kennedy, H. A. Long, D. J. Conway, P. M. Mercer, D. Murphy, M. Stokes, K. Sheahan, N. J. O’Higgins, F. P. Dunne, W. A. Ratcliffe, P. Mansour, D. A. Heath, N. M. O’Meara, J. Sturis, K. C. Herold, K. S. Polonsky, O. L. Beatty, C. M. Ritchie, P. M. Bell, J. C. Levy, E. Turkington, D. W. Hadden, R. Harper, C. N. Ennis, G. D. Johnston, P. Scanlan, M. Foley, J. Stronge, R. Firth, R. L. Hanson, L. T. H. Jacobsson, P. H. Bennett, D. T. Bishop, and W. C. Knowler
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medicine.medical_specialty ,business.industry ,Library science ,General Medicine ,Cork ,engineering.material ,language.human_language ,Regional hospital ,Irish ,Ophthalmology ,engineering ,language ,medicine ,business - Published
- 1994
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24. Waterford Surgical October Club Proceedings of meeting held Saturday, 30th October, 1993
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A. Cheung, David Bouchier-Hayes, P. Burke, D. Chin, K. Duffy, C. J. Kelly, M. Barry, R. Surana, Maqsood Ahmad, J. McCarthy, Declan E. McCormack, Henry Paul Redmond, R. G. W. Watson, S. Rea, Thomas N. Walsh, T. P. J. Hennessy, D. Grehan, J. K. Hickey, A. Nugent, T. Willcocks, Enda W. McDermott, S. Duggan, Jiang Huai Wang, M.J. Duffy, P. Marks, L. Motyka, W. Gallagher, Nollaig A. Parfrey, J. McElwain, D. Bouchier Hayes, P. Puri, C.J. Kelly, James J. Fennelly, M. T. P. Caldwell, I. Reid, David T. Croke, J. R. O’Donnell, John M. Daly, N. J. O’Higgins, and H. Gallagher
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business.industry ,Library science ,Medicine ,General Medicine ,Club ,business - Published
- 1994
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25. Color Doppler sonography in the evaluation of palpable breast masses
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J. C. Miller, N. J. O'higgins, P. M. Mercer, D. P. Macerlean, E. W. M. Mcdermott, and M. M. J. Mcnicholas
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Adult ,medicine.medical_specialty ,Adolescent ,Breast Neoplasms ,Sensitivity and Specificity ,Breast Diseases ,Predictive Value of Tests ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,Breast ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Medical screening ,Histology ,General Medicine ,Blood flow ,Color doppler ,Middle Aged ,Predictive value of tests ,Female ,Ultrasonography, Mammary ,Radiology ,Ultrasonography ,business ,Blood Flow Velocity - Abstract
A prospective study was performed to determine the value of high-resolution color Doppler sonography in the evaluation of palpable solid breast masses.One hundred thirty-one consecutive breast lesions were characterized as benign, malignant, or indeterminate on the basis of their sonographic appearance. The number of blood vessels was estimated, the Doppler spectrum for each vessel was characterized, and the maximum velocity was recorded. Mammography was performed in most cases. Histology was obtained in all cases.Predictions based on sonography alone were correct in 74% of benign lesions and 63% of malignant lesions (p.001). Blood flow was demonstrated in 87% of malignant lesions and in 68% of benign lesions (p = .0105). Malignant lesions were larger than benign lesions (p = .004) and showed a significantly greater number of vessels (p.001) and significantly higher maximum velocity (mean, 34.2 vs 19.2 cm/sec; p.001). Patients with malignant lesions were significantly older (p.001). When age, size of lesion, and sonographic morphology were controlled, the presence of blood flow did not aid in diagnosis. However, in lesions with blood flow, when spectral patterns and maximum velocity were analyzed, a logistic model combining these parameters with age, size, and sonographic morphology gave an overall sensitivity of 94%, specificity of 93%, and positive predictive value of 92%. Mammography yielded useful additional information, particularly for indeterminate lesions.Maximum velocity and spectral patterns on Doppler analysis are useful indicators of breast malignancy, but only if the patient's age, the size of the lesion, and the sonographic morphology are also considered. The best use of color flow imaging is in combination with mammography.
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- 1993
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26. Proceedings of meeting held November 6th & 7th, 1992 in the Sir Charles Parsons Theatre, University of Limerick
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Martin O'Connell, T. V. Keaveney, R. Hussain, J. T. Ennis, David Bouchier-Hayes, W. G. Humphreys, M. P. Brady, O. Traynor, W. Angerson, John G. Murray, D. T. Croke, A. O’Mahony, N. Barrett, M. S. Dudley, A. D. K. Hill, E. C. Coveney, Peter A. Dervan, J. Gerghty, R. G. Barclay, S. K. Al-Ghazal, J. Drumm, R. Alvi, A. Qureshi, P. B. Cotton, P. G. Horgan, P. Fitzgerald, B. O’Leary, I. Kelly, P. M. Mercer, C. Delaney, E. F. Mooney, B. Lane, T. Creagh, P. A. Grace, J. McCann, Y. Ellias, J. Reynolds, J Hyland, D. Breslin, R. O’Donnell, F. O. Cunningham, A. Murphy, J. Smith, Conor Patrick Delaney, J. Geraghty, John M. Fitzpatrick, R. Moloney, P. Keeling, N. Williams, J. A. O’Donnell, N. Brindley, A. Darzi, A. H. Anderson, J. Byrne, Thomas F. Gorey, I. Solomon, S. McDermott, W. Norwood, T. A. Creagh, W. O. Kirwan, J. C. McCarthy, R. G. K. Watson, D. J. Bouchier-Hayes, P. Puri, D. McAvinchey, D. A. Luke, G. L. Hill, W. Watson, S. Johnston, J. G. Geoghegan, K. Khan, C. I. Timon, T. Pembroke, Declan G. Murphy, A. M. Hetherton, M. Morrin, M. Kennedy, A. Hamdy, K. J. Cronin, Gerald C. O'Sullivan, Patrick Collins, P. V. Delaney, J. McCarthy, C. M. Reardon, Mary Leader, B. J. Rowlands, N. J. O’Higgins, P. M. Murchan, A. O’Donnell, P. Kent, R. W. G. Watson, S. Al-Ghazal, John V. Reynolds, H. Browne, Austin Leahy, T. N. Pappas, S. E. Refsum, C. J. Kelly, R. Samsunden, E. McGovern, P. Burke, M. Istarabadi, S. Monkhouse, T. P. Corrigan, A. Young, D. P. McShane, N. N. Williams, P. Irwin, N. Menzies-Gow, M. S. Branch, R. Rasheed, J. K. Collins, M. J. Murray, T. J. Egan, R. Surana, N. F. Couse, M. McKiernan, W. P. Joyce, M. A. Stokes, S. Syed, F. H. Khan, Mukhtar Ahmed, M. D. McCaigue, A. Bohan, J. Callaghan, K. Rasheed, S. T. O’Sullivan, W. A. Tanner, P. E. Burke, M. K. Kerin, M. J. Donnelly, G. K. Ninan, C. Hardiman, Frank Keeling, Henry Paul Redmond, P. P. A. Smyth, F. Khan, S. O’Domhnaill, D. Ramsbottom, Frank B. V. Keane, B. Clements, H. F. Given, L. Rehman, M. Dowling, A. Sarazen, E. J. Guiney, I. M. Halliday, D. Ryan, B. O’Donnell, G. Lynch, Elaine W. Kay, J. Hegarty, S. E. A. Attwood, Michael J. Kerin, J. Dolan, N. Stokes, T. F. Gorey, V. E. Boston, R. J. Fitzgerald, F. Malone, J. O’Neill, and M. Fitzgerald
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business.industry ,Art history ,Medicine ,General Medicine ,business - Published
- 1993
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27. CA 15-3 in patients with locoregional and metastatic breast carcinoma
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E C Coveney, M. J. Dufy, J G Geraghty, F. Sherry, and N. J. O’Higgins
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Oncology ,Cancer Research ,Systemic disease ,medicine.medical_specialty ,biology ,business.industry ,CA 15-3 ,medicine.disease ,Gastroenterology ,Breast cancer ,Carcinoembryonic antigen ,Internal medicine ,Carcinoma ,medicine ,biology.protein ,Breast carcinoma ,business ,Tumor marker ,Recurrent Breast Carcinoma - Abstract
Background. The value of circulating CA 15-3 levels was assessed in 129 patients with recurrent breast carcinoma. Methods. Patients were divided into four subgroups, according to the following: Group A, locoregional recurrence alone; Group B, locoregional and subsequent systemic recurrence; Group C, combined locoregional and systemic recurrence; and Group D, differing sites of systemic disease. Results. One of 14 patients with locoregional disease alone had increased levels of CA 15-3 (> 25 U/ml). However, 96% of patients (22 of 23 patients) with combined local and systemic disease had increased tumor marker levels. The difference in CA 15-3 levels in patients with combined disease compared with patients with local disease alone was statistically significant (117.0 versus 17.5 U/ml, respectively; P < 0.02). Twenty-four patients with locoregional recurrence later had distant metastasis develop. In this group, patients with an increased CA 15-3 value had a significantly shorter lead time to the development of distant metastases compared with patients with normal tumor marker levels (20.8 ± 3.3 versus 10.3 k 2.7 months, respectively; P < 0.03). CA 15-3 values at diagnosis were increased in 88% of 115 patients with metastatic disease. There was no significant difference in CA 15-3 levels among metastases to lung, liver, and bone nor was there any difference between single and multiple sites of distant metastasis. CA 15-3 is an excellent marker for systemic recurrence of breast carcinoma. Conclusions. Increased levels and no clinical evidence of recurrence strongly indicate the presence of occult metastatic disease.
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- 1992
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28. Enzyme-Linked Immunosorbent Assay of C-Erbb-2 Oncoprotein in Breast Cancer
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N. J. O’Higgins, Michael J. Duffy, A. Nugent, Enda W. McDermott, James J. Fennelly, and K. Duffy
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chemistry.chemical_classification ,Pathology ,medicine.medical_specialty ,C erbb 2 ,medicine.drug_class ,Biochemistry (medical) ,Clinical Biochemistry ,Immunocytochemistry ,Biology ,medicine.disease ,Breast cancer ,Enzyme ,chemistry ,Estrogen ,Gene duplication ,medicine ,Cancer research ,skin and connective tissue diseases ,Gene ,Southern blot - Abstract
Amplification or increased expression of the c-erbB-2 gene has previously been reported to be a prognostic marker for breast cancer. Gene amplification is usually measured by Southern blotting, whereas increased protein expression is usually detected by immunocytochemistry. We measured c-erbB-2 protein with an enzyme-linked immunosorbent assay (ELISA). High concentrations of oncoprotein were found in 25 of 161 (16%) primary breast cancers and in 3 of 6 (50%) breast cancer metastases. High concentrations were not found in normal breast tissue or benign breast tumors. In the primary cancers, high concentrations of c-erbB-2 protein were found more frequently (a) in estrogen receptor-negative tumors than in estrogen receptor-positive tumors, (b) in progesterone receptor-negative tumors than in progesterone-positive tumors, and (c) in axillary node-positive cancers than in node-negative cancers. Patients with tumors containing high amounts of the c-erbB-2 protein had a significantly shorter (P less than 0.001) disease-free interval and overall survival rate than did patients with low amounts. We conclude that assay of c-erbB-2 protein by ELISA is simple, rapid, and quantitative and offers important prognostic information in breast cancer.
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- 1992
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29. Sixteenth sir peter freyer memorial lecture and surgical symposium September 13th & 14th, 1991 Session I
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J. Coulter, R. G. Molloy, K. T. Moran, R. Waldron, W. O. Kirwan, C. O’Suilleabhain, A. Horgan, K. Mealy, P. Burke, J. Hyland, A. F. Horgan, M. Sheehan, R. M. Browne, O. Austin, A. P. Clery, J. M. Deasy, S. Sulaiman-Shoaib, J. Soeda, D. S. O’Briain, P. Puri, E. C. Coveney, V. McAllister, E. W. M. McDermott, N. J. O’Higgins, M. Maher, M. T. P. Caldwell, P. Murchan, W. Beesley, T. M. Feeley, W. A. Tanner, F. B. V. Keane, F. Abbasakoor, S. E. A. Attwood, L P. McGrath, R. B. Stephens, E. O’Broin, M. G. Davies, J. McGinley, C. Mannion, S. Gupta, M. F. Shine, F. Lennon, G. Ninan, R. J. Fitzgerald, E. J. Guiney, B. O’Donnell, A. F. O’Donnell, D. Luke, A. E. Wood, P. G. Murphy, T. N. Walsh, A. D. K. Hill, H. Li, T. P. J. Hennessy, N. Noonan, B. Breslin, P. W. N. Keeling, A. J. Curran, D. B. Gough, I. R. Davidson, P. Keeling, D. P. O’Leary, A. Smythe, N. C. Bird, A. G. Johnson, P. Nicholson, O. Traynor, K. Dawson, J. Aitken, B. A. Cooke, S. P. Parbhoo, N. N.Williams, J. M. Daly, M. Herlyn, D. Bouchier-Hayes, R. C. Stuart, M. J. Allen, W. D. Thompson, A. L. G. Peel, D. T. Hehir, K. Cronin, A. McCann, P. A. Dervan, S. J. Heffernan, W. P. Hederman, M. H. Galea, B. Dilks, A. Gilmour, L. O. Ellis, C. W. Elston, R. W. Blarney, S. O’Rourke, A. Mookens, R. Carter, D. Parkin, N. F. Couse, C. P. Delaney, P. G. Horgan, J. M. Fitzpatrick, T. F. Gorey, J. M. O’Byrne, J. P. McCabe, M. Stephens, F. McManus, J. L.Mangan, D. A. Barr, G. J. Mulvenna, P. Maginn, W. G. Kernohan, R. A. B. Mollan, S. J. O’Flanagan, J. P. Stack, P. Dervan, B. Hurson, S. Tierney, P. Fitzgerald, T. O’Sullivan, P. Grace, J. P. Wyatt, R. J. Evans, S. P. Cusack, S. McGowan, E. McGovem, S. D. Schwaitzberg, R. J. Connolly, R. P. Sullivan, G. Mortimer, J. G. Geraghty, P. J. O’Dwyer, B. S. McGlone, D. P. O’Brien, H. A. Younis, H. F. Given, C. Phelan, J. Byrne, K. Barry, D. Gough, L. Hanrahan, F. Given, J. P. Sweeney, A. M. Korebrits, J. V Reynolds, T. F Gorey, D. M. O’Hanlon, M. A. Stokes, H. P. Redmond, J. McCarthy, P. Losty, M. Murphy, P. E. M. Butler, P. G. Grace, J. R. Novell, S. K. Hobbs, O. Smith, G. Hazlehurst, B. Brozovic, K. Rolles, A. Burroughs, S. Mallett, A. Mehta, D. Buckley, D. Waldron, D. O’Brien, C. Curran, L. Grey, A. Leahy, A. Darzi, D. Leader, P. Broe, J. G. Geoghegan, C. A. Cheng, D. C. Lawson, T. N. Pappas, D. O’Sullivan, M. M. Lieber, T. V Colby, D. M. Barrett, E. Rogers, J. Greally, H. C. Bredin, M. O. Corcoran, M. Kenny, P. Horgan, D. Headon, A. Grace, P. A. Grace, S. Cross, D. Hehir, S. O’Briain, P. Hartigan, M. P. Colgan, D. Moore, G. Shanik, S. Z. Zaidi, D. J. Hehir, K. S. Cross, D. J. Moore, D. G. Shanik, P. Lacy, J. E. Coleman, C. S. McEnroe, J. A. Gelfand, T. F. O’Donnell, A. D. Callow, D. J. Buckley, D. S. O’Riordain, J. A. O’Donnell, P. Meagher, K. Boos, P. Gillen, T. Corrigan, R. Vashisht, M. Sian, E. J Sharp, M. K. O’Malley, M. J. Kerin, D. Wilkinson, A. Parkin, R. C. Kester, M. M. Maher, R. P. Waldron, D. J. Waldron, M. P. Brady, M. Allen, T. H Lyncy, B. Waymont, L. Emtage, G. R. Blackledge, M. A. Hughes, D. M. A. Wallace, L. Mynderse, H. Grimes, F. Chambers, D. Lowe, B. Prasad, D. C. O’Sullivan, M. Barry P. Gillen, M. McNicholas, H. Bredin, T. H. O’Dowd, M. Corcoran, J. M. O’Donoghue, M. McGuire, A. McNamara, T. Creagh, R. Grainger, T. B. D. McDermott, M. R. Butler, M. Gleeson, T. E. D. McDermott, J. P. Hurley, R. Hone, M. Neligan, J. Hurley, M. White, P. McDonagh, D. Phelan, E. McGovern, F. Quinn, F. Breatnach, A. O’Meara, J. P. McGrath, S. R. McCann, E. F. Gaffney, A Hennessy, M. Leader, F. S. Taleb, M. V. McKiernan, P. J. Leyden, J. J. McCann, J. Coleman, A. Quereshi, N. Ajayi, G. McEntee, H. Osborne, D. J. Bouchier-Hayes, S. Johnston, K. O’Malley, E. Smyth, D. L Bouchier-Hayes, P. R. O’Connell, T. Gorey, O. J. McAnena, M. W. Reed, J. L. Duncan, C. S. Reilly, C. McGibney, P. Lawlor, B. Lawless, E. McGuinness, and S. Leahy
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business.industry ,Medicine ,General Medicine ,Session (computer science) ,business ,Classics - Published
- 1992
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30. Acute colonic obstruction due to benign prostatic hypertrophy
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S, Mac Giobuin, D O, Kavanagh, R, Ryan, A, Kinsella, E, Myers, D, Evoy, N J, O'Higgins, and E, McDermott
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Male ,Tomography, X-Ray ,Acute Disease ,Prostatic Hyperplasia ,Humans ,Urinary Retention ,Intestinal Obstruction ,Aged - Abstract
A seventy two year old man presented to the Emergency Department with clinical features of colonic obstruction. Subsequent radiological investigations confirmed this impression and revealed the aetiology to be compression of the sigmoid colon against the sacrum by a massively distended urinary bladder. Chronic urinary retention due to benign prostatic hypertrophy is an extremely unusual cause of large bowel obstruction. Little in this patient's clinical findings suggested this aetiology. We reviewed the literature in this area and highlight the benefits of CT scanning over contrast studies.
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- 2009
31. Fifteenth Sir Peter Freyer Memorial Lecture and Surgical Symposium Proceedings of meeting held 14th & 15th September, 1990 at University College, Galway
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C. Bolger, G. Fry, D. Coakley, J. Philips, N. Sheahan, J. Malone, W. P. Gray, M. O’Sullivan, T. F. Buckley, T. P. O’Dwyer, P. J. Gullane, B. P. Kneafsey, K. T. Moran, S. T. O’Sullivan, M. P. Brady, E. C. Coveney, J. G. Geraghty, N. J. O’Higgins, J. O’Beirne, P. Seighe, J. P. McElwain, J. P. McCabe, B. Waldron, J. Byme, N. Hickey, J. McCabe, J. McMahon, J. Colville, B. J. Moran, R. A. Frost, M. J. Kerin, J. J. Jaeger, C. J. Mitchell, J. MacFie, T. O’Hanrahan, N. A. Scott, D. Leinhardt, M. H. Irving, D. Gough, M. White, M. Morrin, W. Joyce, D. Phelan, J. Fitzpatrick, T. Gorey, D. Wilkinson, A. Parkin, R. C. Kester, E. J. Gibney, K. McGrath, A. J. Cunningham, D. Bouchier-Hayes, M. Barry, M. Farrell, W. Monkhouse, K. J. Dawson, D. Hehir, G. Hamilton, P. A. Grace, A. Quereschi, R. Keane, P. Broe, G. Stansby, B. Fuller, A. Connolly, J. O’Donnell, D. Little, R. M. Keane, M. Regan, P. G. Horgan, C. Curran, D. O’Brien, D. Waldron, E. Mooney, J. Greally, H. F. Given, M. J. Duffy, D. Reilly, E. Coveney, J. Geraghty, J. J. Fennelly, N. O’Higgins, C. M. O’Hare, P. L. Jones, T. A. Zoma, G. P. Hemstreet, R. G. Postier, J. E. Coleman, E. L. Chaikof, E. W. Merrill, A. D. Callow, N. N. Williams, J. M. Daly, M. Herlyn, R. Gaffney, M. Walsh, D. McShane, C. Timon, D. Hamilton, J. Connolly, P. J. Byrne, R. B. Stuart, E. Kay, T. P. J. Hennessy, D. P. O’Leary, M. Booker, T. E. Scott, W. W. LaMorte, J. G. Geraty, W. A. Angerson, D. C. Carter, J. Lyons, A. Stack, J. M. Fitzpatrick, C. Kelly, C. Augustine, J. Kennedy, T. Creagh, D. Mannion, P. Seigne, G. Fitzpatrick, M. Feeley, P. Butler, P. Grace, M. Leader, B. Curren, C. Barry-Walsh, R. Waldron, M. Shearer, S. O’Rourke, M. Galea, A. Gilmour, R. Carter, D. Parkin, R. W. Blarney, D. J. Hehir, S. P. Parbhoo, N. Rothnie, J. Crowe, C. Wells, F. Sherry, P. O’Grady, J. Byrne, S. England, J. O’Callaghan, H. Grimes, Ursula Mulcahy, P. P. A. Smyth, V. McAlister, M. J. Murray, M. J. O’Higgins, R. O. Laoide, J. B. Hourihane, E. F. Mooney, C. Brougham, D. R. Headon, C. Coleman, E. C. Coveny, S. Jazawi, T. N. Walsh, P. Lawlor, H. Li, H. Sanfey, W. P. Joyce, D. B. Gough, P. V. Delaney, T. F. Gorey, S. E. A. Attwood, A. Watson, E. Rogers, R. P. Waldron, G. Glynn, K. U. El-Bouri, J. Flynn, P. Keeling, M. G. Davies, J. Lavelle, M. F. Shine, F. Lennon, R. C. Stewart, T. P. Hennessy, M. V. McKiernan, J. G. Johnston, L. Hanrahan, H. C. Bredin, M. O. Corcoran, M. Norton, R. Flynn, M. Gleeson, R. Grainger, T. E. D. McDermott, D. Lanigan, P. McLean, B. Curran, M. J. Gleeson, D. P. Griffin, H. J. Gallagher, T. A. Creagh, D. M. Mulvin, M. G. Donovan, D. M. Murphy, P. A. McLean, D. W. Mulvin, A. O’Brien, K. L. O’Flynn, R. McDonagh, D. G. Thomas, T. H. Lynch, P. Anderson, A. T. M. Vaughan, R. P. Beaney, D. M. A. Wallace, L. Solomon, D. S. O’Riordain, P. R. O’Connell, W. O. Kirwan, Hui Li, R. C. Stuart, S. Jazrawi, T. N. Koh, S. J. Sheehan, J. McKeever, J. Donohoe, M. Carmody, D. H. Osborne, D. E. Waldron, E. Rodgers, F. Patel, P. Horgan, M. Corcoran, K. Walsh, J. M. O’Donoghue, O. J. McAnena, M. McGuire, J. Smyth, G. Keye, A. Bahadursingh, C. Delaney, A. J. Richie, J. R. P. Gibbons, M. Marples, J. Banacewicz, H. Troidl, L. Cassidy, E. J. Prenderville, P. E. Burke, M. -.P Colgan, B. L. Wee, D. J. Moore, G. D. Shanik, K. S. Cross, M. El-Sanadiki, J. J. Murray, E. Mikat, R. McCann, P. -O. Hagen, T. R. Cheatle, E. Steibe, P. D. Colebridge Smith, J. H. Scurr, K. Barry, E. Bresnihan, D. F. Courtney, D. S. Quill, D. Buckley, D. S. O’Riordan, J. A. O’Donncll, J. A. O’Donnell, A. D. K. Hill, P. J. O’Dwycr, D. P. MacErlean, N. F. Couse, D. Campbell, K. McBride, D. MacErlean, J. J. Murphy, K. Kaar, H. Docrat, S. Malik, J. Egan, I. R. Davidson, J. Hurley, and H. Rowley
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Artificial urinary sphincter ,medicine.medical_specialty ,Fifteenth ,Chronic venous insufficiency ,business.industry ,Intestinal failure ,General surgery ,medicine ,General Medicine ,medicine.disease ,business ,Laparoscopic cholecystectomy - Published
- 1991
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32. Irish society of gastroenterology
- Author
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G. Daly, A. L. Leahy, D. Cottell, T. F. Gorey, D. J. Bouchier-Hayes, M. Barry, P. W. N. Keeling, K. Scott, J. Feely, M. Feeley, C. O’Morain, A. Darzi, W. A. Tanner, F. B. V. Keane, A. Tobin, Y. Suzuki, E. Leen, T. O’Riordan, P. O’Byrne, A. Newland, N. S. Williams, P. Kelly, T. Brady, L. Langrell, F. Feighery, D. G. Weir, C. Fenlon, T. Ryan, J. Hyland, F. Bergin, M. G. Courtney, D. P. Nunes, G. S. A. McDonald, A. Leahy, J. R. T. Monson, J. P. Stevens, C. C. McCombe, M. A. McCarthy, F. McCarthy, F. M. Stevens, J. F. Greally, D. M. Little, R. M. Keane, M. R. Regan, E. Kaye, S. Monkhouse, D. Bouchier-Hayes, M. Lombard, M. Hynes, J. Crow, J. Moran, A. A. Jackson, C. Persaud, S. J. Karran, M. Chir, A. Bomford, R. Poison, R. Williams, D. Nunes, C. P. Kelly, D. Quinn, A. Whelan, C. A. O’Morain, K. C. Trimble, A. G. Shattock, F. M. Mulcahy, J. Deasy, A. P. Clery, N. Noonan, J. Keating, M. Healy, R. O’Rourke, O. Corrigan, R. Henihan, R. Stuart, E. Lean, D. McKerma, T. P. J. Hennessy, M. D. Davies, M. J. Rowan, P. MacMathuna, R. Merriman, J. Crowe, J. Lennon, S. Ahkion, A. Chua, N. Keeling, E. Sinclair, S. Barry, N. Antowan, T. Dinan, I. M. Reid, Elaine Kay, Philippa Marks, E. Kenny, R. Waldron, K. Buchanan, W. Kirwan, M. J. Whelton, S. Patchett, S. Redmond, L. O’Donnell, K. M. Geeney, D. P. O’Donoghue, M. Kerin, V. O’Malley, D. O’Farrell, O. McAnena, J. Callaghan, F. Given, S. J. Kirk, I. V. Allen, J. T. Lawson, T. G. Parks, A. Ali, M. McGuire, C. McCarthy, H. F. Given, H. J. O’Connor, R. Vickers, J. A. C. Buckels, P. MacMaster, E. Elias, J. M. Neuberger, D. S. O’Riordain, P. Losty, P. J. O’Dwyer, and N. J. O’Higgins
- Subjects
Irish ,business.industry ,language ,Optometry ,Library science ,Medicine ,General Medicine ,business ,language.human_language - Published
- 1991
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- View/download PDF
33. Premorphological metabolic changes in human breast carcinogenesis
- Author
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Enda W. McDermott, P. P. A. Smyth, E. T. Barren, and N. J. O’Higgins
- Subjects
Adult ,Pathology ,medicine.medical_specialty ,Normal tissue ,Breast Neoplasms ,Glucosephosphate Dehydrogenase ,medicine.disease_cause ,Breast cancer ,Risk Factors ,medicine ,Humans ,Breast carcinogenesis ,Breast ,skin and connective tissue diseases ,Aged ,Aged, 80 and over ,Histocytochemistry ,business.industry ,Cancer ,Middle Aged ,medicine.disease ,Surgery ,Abnormality ,Carcinogenesis ,business ,Metabolic activity ,Precancerous Conditions ,Human breast - Abstract
Malignant breast tissue is characterized by morphological and metabolic changes when compared with normal breast tissue. In this study, the cytochemical measurement of glucose-6-phosphate dehydrogenase (G6PD) activity was used to detect abnormal metabolism in breast tissue and to determine whether abnormal metabolic activity precedes morphological change during human breast carcinogenesis. Normal and benign breast tissue, morphologically normal tissue from cancer-containing breasts, and malignant breast tissue were studied. In malignant tissue, mean(s.e.m.) G6PD activity was significantly increased when compared with normal and benign tissue (9.69(2.3) versus 27.02(1.7) mean integrated extinction (MIE) × 100, P
- Published
- 1990
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34. Irish endocrine society
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C. H. Walsh, A. L. Murphy, S. Cunningham, T. J. McKenna, B. Byrne, D. Igoe, S. K. Cunningham, M. Culliton, C. Costigan, J. A. McKnight, D. R. McCance, G. Roberts, B. Sheridan, A. B. Atkinson, O. Lanigan, P. O’Leary, T. Moran, P. P. A. Smyth, D. R. Hadden, L. Kennedy, D. Foley-Nolan, A. Foley-Nolan, D. Temperley, J. Devlin, P. M. Bell, R. D. G. Neely, D. P. Rooney, E. R. Trimble, J. D. M. Edgar, R. Doherty, A. B. Atkinsion, J. A. O’Hare, L. Rand, A. Krolewski, C. McKenna, J. McKieman, H. M. Whitehead, K. Buchanan, Davina Fillmore, Joy Ardill, C. Johnston, Wendy Robinson, G. Silvestri, J. A. Dunn, D. G. Dwyer, J. W. Baynes, T. J. Lyons, D. Owens, J. Stinson, P. Collins, A. Johnson, G. Tomkin, D. F. Smith, D. O’Carroll, M. Murray, N. J. O’Higgins, A. M. Hetherton, T. B. Counihan, D. B. R. Poole, D. K. O’Donovan, H. Grimes, and J. O’Donnell
- Subjects
Metyrapone ,business.industry ,Physiology ,General Medicine ,Renal artery stenosis ,medicine.disease ,Plasma renin activity ,language.human_language ,Irish ,medicine ,language ,Endocrine system ,business ,medicine.drug - Published
- 1990
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35. Percutaneous endoscopic gastrostomy: 5 years of clinical experience on 238 patients
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J J, Sheehan, A D K, Hill, N P, Fanning, C, Healy, E W, McDermott, D P, O'Donoghue, and N J, O'Higgins
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Adult ,Aged, 80 and over ,Gastrostomy ,Male ,Adolescent ,Cystic Fibrosis ,Middle Aged ,Pneumonia, Aspiration ,Central Nervous System Diseases ,Neoplasms ,Gastroscopy ,Humans ,Female ,Aged ,Retrospective Studies - Abstract
Since Percutaneous Endoscopic Gastrostomy (PEG) feeding was introduced, 20 years ago it has been increasingly utilised in medical practice. The aim of this study was to assess the current indications and complications associated with PEG feeding. This study was a retrospective review of hospital charts dealing with PEG placement over a period of five years. The indications for insertion were, central nervous disease 76% (n = 156), other benign disease 14% (n = 28) and malignancy 10% (n = 21). Cerebrovascular accidents (CVA) alone accounted for 47% (n = 97). Ninety seven (50%) patients had minor complications, which included 43 (22%) wound infections. There were 6 (3%) major complications, including peritonitis, perforation and aspiration pneumonia. There were four deaths (2%) related to PEG placement, of whom three developed aspiration pneumonia and one peritonitis. The overall 30 day mortality rate was 16%. There was a 75% increase in the use of PEG placement over the five year period. PEG placements were associated with a 53% morbidity and a 2% procedure related mortality. There was a 16% 30 day mortality following PEG placement suggesting that the selection criteria for PEG placement may need to be refined further.
- Published
- 2004
36. Assay of the c-erbB-2 Oncogene Encoded Protein by ELISA and Immunocytochemistry in Human Breast Cancer
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N. J. O’Higgins, J Gallagher, A Nugent, J Dolan, and Michael J. Duffy
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Receptor, ErbB-2 ,Clinical Biochemistry ,Immunocytochemistry ,Mammary gland ,Breast Neoplasms ,Enzyme-Linked Immunosorbent Assay ,Biology ,Gene product ,03 medical and health sciences ,Proto-Oncogene Proteins ,Gene duplication ,Biomarkers, Tumor ,medicine ,Humans ,skin and connective tissue diseases ,Gene ,030102 biochemistry & molecular biology ,Cancer ,General Medicine ,medicine.disease ,Immunohistochemistry ,Molecular biology ,ErbB Receptors ,030104 developmental biology ,medicine.anatomical_structure ,Human breast ,Quantitative analysis (chemistry) - Abstract
The c-erbB-2 gene is amplified in a wide variety of different adenocarcinomas. Generally, gene amplification correlates with increased expression of the c-erbB-2 oncoprotein. Previous assays for the c-erbB-2 oncoprotein have been qualitative or semi-quantitative. In this investigation using human breast cancers, c-erbB-2 oncoprotein levels as measured by enzyme-linked immunosorbent assay (ELISA) correlated significantly with semi-quantitation by immunocytochemistry ( r = 0·843, P
- Published
- 1994
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37. Studies on oestrogen receptor-alpha and -beta mRNA in breast cancer
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R, Cullen, T M, Maguire, E W, McDermott, A D, Hill, N J, O'Higgins, and M J, Duffy
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Receptors, Estrogen ,Fibroadenoma ,Reverse Transcriptase Polymerase Chain Reaction ,Biomarkers, Tumor ,Estrogen Receptor alpha ,Estrogen Receptor beta ,Humans ,Breast Neoplasms ,Female ,RNA, Messenger ,Carrier Proteins ,Receptors, Progesterone ,Neoplasm Proteins - Abstract
The oestrogen receptor (ER) is widely used to predict response to tamoxifen in patients with breast cancer. Recently a new form of ER known as ER-beta was discovered, the original ER is now designated ER-alpha. In this investigation, ER-alpha and ER-beta were measured in 107 breast carcinomas and 22 fibroadenomas. Using reverse transcriptase-polymerase chain reaction (RT-PCR), ER-beta mRNA, but not ER-alpha mRNA was expressed more frequently in fibroadenomas than carcinomas. In the carcinomas, ER-beta mRNA was present in a greater proportion of samples positive for ER-alpha mRNA than in those lacking this form of the receptor. ER-alpha, but not ER-beta mRNA, was significantly associated with ER protein-positivity in the cancers. ER-alpha mRNA was also positively related to progesterone receptors (PR), but ER-beta mRNA showed an inverse relationship with PR. We conclude that the presently used enzyme-linked immunosorbent assay (ELISA) for ER appears to be mostly measuring ER-alpha and is unlikely to be detecting ER-beta.
- Published
- 2001
38. Cathepsin D Concentration in Breast Cancer Cytosols: Correlation with Disease-Free Interval and Overall Survival
- Author
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C. Faul, N. J. O’Higgins, J.-P. Brouillet, D. Reilly, Enda W. McDermott, T. Maudelonde, Michael J. Duffy, James J. Fennelly, and H. Rochefort
- Subjects
medicine.medical_specialty ,Disease free interval ,business.industry ,Biochemistry (medical) ,Clinical Biochemistry ,Cathepsin D ,Radioimmunoassay ,medicine.disease ,Correlation ,Breast cancer ,Endocrinology ,Internal medicine ,medicine ,Overall survival ,Receptor ,business ,Survival rate - Abstract
Cathepsin D (CD) is an aspartyl protease implicated in cancer metastasis. In this study of 331 patients, we show that patients with primary breast carcinomas containing high concentrations of CD have a significantly shorter disease-free interval (chi-square = 4.28, P < 0.05) and overall survival (chi-square = 7.7, P < 0.01) than patients with low concentrations. CD as a prognostic marker for overall survival was equally valuable for women younger (chi-square = 4.39, P < 0.05) and older (chi-square = 3.97, P < 0.05) than 50 years. CD was also a significant prognostic marker for overall survival within the estradiol receptor (ER)-positive subgroup of patients (chi-square = 5.79, P < 0.025), but not in the ER-negative subgroup. Patients with tumors containing high concentrations of CD and low concentrations of ER had shorter disease-free intervals (chi-square = 15.1, P < 0.001) and lower overall survival (chi-square = 20.9, P < 0.001) than patients with high concentrations of ER but low concentrations of CD.
- Published
- 1992
- Full Text
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39. Preoperative CA 15-3 concentrations predict outcome of patients with breast carcinoma
- Author
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S G, Shering, F, Sherry, E W, McDermott, N J, O'Higgins, and M J, Duffy
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Receptors, Estrogen ,Lymphatic Metastasis ,Axilla ,Mucin-1 ,Biomarkers, Tumor ,Humans ,Breast Neoplasms ,Female ,Prospective Studies ,Middle Aged ,Receptors, Progesterone ,Disease-Free Survival - Abstract
CA 15-3 is a breast-associated mucin that is elevated in the majority of breast carcinoma patients with distant metastases. Currently, the main application of this marker is in monitoring and detecting recurrences in patients with diagnosed breast carcinoma.Preoperative serum concentrations (prior to excision of the primary tumor) of CA 15-3 were measured in 368 patients undergoing potentially curative surgical treatment for early breast carcinoma. These results were compared with prospectively recorded clinicopathologic characteristics and patient outcome data.A weak but significant positive association was found between CA 15-3 concentrations and both tumor stage and the number of involved axillary lymph nodes but not between CA 15-3 concentrations and estrogen receptor status. Patients with high concentrations of CA 15-3 had a significantly worse prognosis than patients with low concentrations. Using an optimum cutoff value of 30.38 U/mL, the probability of disease free survival at 5 years was 44% in patients with high CA 15-3 levels compared with 65% in patients with low CA 15-3 levels (P = 0.002, Mantel-Cox log rank test). The corresponding probabilities for overall survival were 67% and 83%, respectively (P0.001). The association of preoperative CA 15-3 levels with outcome was maintained in multivariate survival analysis and was not explained by the association between CA 15-3 and tumor size or lymph node burden. The relation between CA 15-3 and outcome also was found within some patient subgroups identified by traditional prognostic factors (axillary lymph node positive patients, patients with primary tumors2 cm in greatest dimension, and patients with estrogen receptor positive tumors).Preoperative serum concentrations of CA 15-3 appear to have a significant relation to outcome in patients with early breast carcinoma and may have a role in the rational selection of patients for appropriate adjuvant treatments. To the authors' knowledge, CA 15-3 thus is one of the first circulating markers shown to be an independent prognostic indicator in patients with breast carcinoma.
- Published
- 1999
40. Serum thyroid peroxidase autoantibodies, thyroid volume, and outcome in breast carcinoma
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P P, Smyth, S G, Shering, M T, Kilbane, M J, Murray, E W, McDermott, D F, Smith, and N J, O'Higgins
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Adult ,Aged, 80 and over ,Radioimmunoassay ,Thyroid Gland ,Thyrotropin ,Breast Neoplasms ,Middle Aged ,Prognosis ,Iodide Peroxidase ,Survival Analysis ,Thyroxine ,Risk Factors ,Humans ,Female ,Aged ,Autoantibodies - Abstract
The prevalence of thyroid peroxidase autoantibodies (TPO.Ab) was assessed in patients with either breast carcinoma or benign breast disease, and its association with disease outcome in breast carcinoma was studied. TPO.Ab were detected by direct RIA in serum from 121/356 (34.0%) of patients with breast carcinoma, compared with 36/194 (18.5%) of controls (P0.001); and in 31/108 (28.7%) with benign breast disease, compared with 12/88 (13.6%) of controls (P0.05). Survival analysis in a group of 142 women with breast carcinoma demonstrated that TPO.Ab titresor = 0.3 U/mL were associated with a significantly better disease-free [relative risk (RR) = 1.84, P0.05] and overall survival (RR = 3.46, P0.02), compared with those who were TPO.Ab-negative. Better outcome associated with higher TPO.Ab titres was confined to those who had thyroid volumes within the intermediate range (10.1-18.8 mL) and did not further enhance the good outcome recorded when volumes wereor = 10.0 mL or18.8 mL. Multivariate survival analysis showed that both TPO.Ab and thyroid volume were independently associated with prognosis in breast carcinoma and that RRs for disease-free survival were of a similar order of magnitude to well-established prognostic indices such as axillary nodal status or tumor size. These findings supply evidence that manifestations of thyroid autoimmunity are associated with a beneficial effect on disease outcome in breast carcinoma and provide the strongest evidence to date of a biological link between breast carcinoma and thyroid disease.
- Published
- 1998
41. A 25 year review of parotid surgery
- Author
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A P, Zbar, A D, Hill, S G, Shering, M A, Rafferty, M, Moriarty, E W, McDermott, and N J, O'Higgins
- Subjects
Male ,Survival Rate ,Incidence ,Surgical Procedures, Operative ,Humans ,Female ,Parotid Diseases ,Registries ,Ireland ,Follow-Up Studies ,Parotid Neoplasms - Abstract
At a single institution over 25 years, 110 patients were operated upon for a mixture of parotid disease. The mean duration of symptoms for benign disease was 40.8 months compared with 15.6 months for malignant disease. Pain was a significant feature of malignant parotid disorders (46.1% compared with 17.8% for benign conditions). The pathology of these masses was diverse, with pleomorphic adenoma being the commonest (44%). Superficial parotidectomy was the commonest procedure employed (69/110) with local excision being performed only prior to 1984 (15/110). There were five cases of permanent facial palsy, all following radical resection for malignancy. One patient developed Frey's syndrome. Recurrence rate for pleomorphic adenomas was 7/48 (15%), three following enucleations prior to 1984. In primary malignancy of the parotid, 3/21 (14%) developed recurrences. Parotid tumours have a low incidence. Surgery for these tumours can be safely performed by those with a special interest in parotid surgery.
- Published
- 1998
42. Hereditary breast cancer
- Author
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A D, Hill, J M, Doyle, E W, McDermott, and N J, O'Higgins
- Subjects
Mutation ,Genes, BRCA1 ,Humans ,Breast Neoplasms ,Female ,Genetic Predisposition to Disease ,Genetic Testing ,Forecasting - Abstract
Hereditary breast cancer is thought to account for less than 10 per cent of all breast cancers. Recently there have been significant advances in understanding of the genetics, with the sequencing of the genes BRCA1 and BRCA2 which are associated with hereditary breast cancer.Current understanding of hereditary breast cancer and its impact on the management of women with this disease is reviewed.Problems in accurate testing for breast cancer-associated genes remain. No reliable simple test exists because of the large number of mutations present in these genes. The implications of different mutations remain poorly understood. Guidelines for the management of carriers of the breast cancer-associated genes remain controversial.
- Published
- 1997
43. Cervical exploration for primary hyperparathyroidism--A 25 year experience
- Author
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M A, Rafferty, A D, Hill, A P, Zbar, S G, Shering, M, Lucey, E W, McDermott, and N J, O'Higgins
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Adult ,Male ,Parathyroidectomy ,Hyperparathyroidism ,Incidence ,Middle Aged ,Sex Factors ,Hypercalcemia ,Humans ,Calcium ,Female ,Ireland ,Neck ,Aged - Abstract
Parathyroidectomy should be considered in every patient with hypercalcaemia and primary hyperparathyroidism even if the symptoms are vague. Cervical exploration is a safe operation with very satisfactory results. Our experience in 214 patients over 25 years shows permanent postoperative normocalcaemia in 95% of cases with a complication rate of 2.8%. All patients with primary HPT, regardless of age or the severity of symptoms should be candidates for cervical exploration.
- Published
- 1997
44. Assay of E-cadherin by ELISA in human breast cancers
- Author
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T. Maguire, N. J. O’Higgins, Enda W. McDermott, Michael J. Duffy, S.G. Shering, John Crown, and James J. Fennelly
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,Mammary gland ,Detergents ,Breast Neoplasms ,Enzyme-Linked Immunosorbent Assay ,Biology ,Adhesion protein ,Disease-Free Survival ,Metastasis ,Breast cancer ,Cytosol ,medicine ,Biomarkers, Tumor ,Humans ,skin and connective tissue diseases ,Small tumors ,chemistry.chemical_classification ,Cadherin ,medicine.disease ,Cadherins ,Prognosis ,Survival Rate ,medicine.anatomical_structure ,Oncology ,chemistry ,Receptors, Estrogen ,Fibroadenoma ,Lymphatic Metastasis ,Cancer research ,Female ,Glycoprotein ,Human breast ,Follow-Up Studies - Abstract
E-cadherin is a membrane-bound adhesion glycoprotein. Loss of E-cadherin has been correlated with invasion and metastasis in model systems. Using a new ELISA, we found higher levels of E-cadherin in fibroadenomas than in primary breast cancers. Levels in primary cancers showed no significant relationship with either tumour size, nodal status or oestrogen receptor levels. Patients with breast cancers containing low levels of the adhesion protein had a significantly shorter disease-free interval than patients with high levels ( P = 0.041). The prognostic value of E-cadherin, for disease-free interval, was also found in node-negative patients as well as in patients presenting with small tumors (⩽ 2 cm). In conclusion, loss of E-cadherin expression in human breast cancers is associated with increased metastatic potential as has previously been found in model systems. Loss of E-cadherin is thus likely to contribute to breast cancer progression.
- Published
- 1997
45. Thyroid disorders and breast cancer
- Author
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S G, Shering, A P, Zbar, M, Moriarty, E W, McDermott, N J, O'Higgins, and P P, Smyth
- Subjects
Hypothyroidism ,Goiter ,Case-Control Studies ,Prevalence ,Humans ,Breast Neoplasms ,Female ,Disease Susceptibility ,Hyperthyroidism ,Ultrasonography - Abstract
We have investigated the controversial association between diseases of the thyroid gland and breast carcinoma using methodology which allows positive exclusion of cases of breast disease from control groups and the detection of subclinical alterations in thyroid volume using high resolution ultrasonography, thus addressing the deficiencies of earlier studies. Whereas the prevalence of hyperthyroidism and hypothyroidism in patients with breast carcinoma and in healthy controls without clinical evidence of breast disease was similar, non-toxic goitre was more than twice as common in the breast carcinoma patients. Thyroid volumes were also significantly higher in breast carcinoma patients than in controls; using World Health Organisation criteria, 45.5% of breast carcinoma patients had thyroid enlargement compared with only 10.5% of controls. Finally, antithyroid peroxidase autoantibodies were twice as common in breast cancer patients than in controls. These findings provide clear evidence of a relationship between thyroid disease and breast carcinoma, although the mechanisms underlying this relationship require further study, future studies of breast cancer risk factors should therefore include assessment of thyroid function, antibody status and volume.
- Published
- 1996
46. Continuing medical education in oncology in Europe
- Author
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N. J. O’Higgins, P.J. Broe, J.P. Armand, Alberto Costa, James Geraghty, au]J. de Toeuf, D.Th. Sleijfer, and L. Holmberg
- Subjects
Oncology ,Cancer Research ,European level ,medicine.medical_specialty ,Quality Assurance, Health Care ,media_common.quotation_subject ,International Cooperation ,Medical Oncology ,Continuing medical education ,Internal medicine ,medicine ,Member state ,media_common.cataloged_instance ,Humans ,Moral responsibility ,Obligation ,European union ,Duty ,media_common ,business.industry ,Financing, Organized ,Europe ,Private practice ,Education, Medical, Continuing ,Educational Measurement ,business - Abstract
A European Conference on Continuing Medical Education (CME) in Oncology was designed and organised in Dublin (Ireland), on 12th and 13th October 1995 by the European School of Oncology in collaboration with University College Dublin and with the financial support of the European Commission (Europe Against Cancer Programme). Two experts were invited from each Member State and all attended the Conference with the sole exception of the representatives of Luxembourg, who did not attend due to unexpected important commitments. Observers were invited to contribute to the discussion as representatives of organisations that were involved either directly or indirectly in CME. The Conference took the format of a plenary session coupled with the identification of five discussion groups formed to debate key areas in CME at a European level in oncology (Table 1). As a result of these discussions and subsequent consultations, an agreement was reached on the following statements: 1. (a) Continuing Medical Education (CME) is an ethical duty and an individual responsibility for each doctor. Although CME should remain voluntary at the present time, it is nevertheless a professional obligation since almost 50% of medical knowledge becomes obsolete after ten years. It should be organised with clear guidelines for medical personnel working in hospitals, in primary health care and in private practice. 2. (b) The CME system within the European Union (EU) should remain self-directed without the necessity for interval examinations: it should be interdisciplinary and must be driven and controlled by the profession itself. 3. (c) A common concept and system within a CME framework may have a considerable impact on EU integration. It should certainly be developed, maintained and monitored at national level but on the basis of a common European model to ensure scientific and cultural interchange among Member States. 4. (d) It was agreed that a credit system is needed to help doctors keep track of their CME activities: the system should be based on the accumulation of credit points (one credit equalling one hour of continuing medical education) and monitored at a national level. Credit transfer among Member States is vital to facilitate exchange between Member States. 5. (e) Oncology provides a very useful model of CME within which guidelines can be proposed and tested. Harmonisation of CME systems among the different European cancer organisations and scientific societies within this model system may represent a useful basis that other specialities can follow.
- Published
- 1996
47. Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer
- Author
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Michael J. Duffy, Catherine Duggan, Enda W. McDermott, T. Maguire, N. J. O’Higgins, and James J. Fennelly
- Subjects
Cancer Research ,Time Factors ,Mammary gland ,Breast Neoplasms ,Receptors, Cell Surface ,Metastasis ,Receptors, Urokinase Plasminogen Activator ,Plasminogen Activators ,Breast cancer ,Cell surface receptor ,medicine ,Humans ,Neoplasm Metastasis ,skin and connective tissue diseases ,Receptor ,neoplasms ,business.industry ,Cancer ,medicine.disease ,Prognosis ,Urokinase-Type Plasminogen Activator ,biological factors ,Urokinase receptor ,enzymes and coenzymes (carbohydrates) ,medicine.anatomical_structure ,Oncology ,Cancer research ,biological phenomena, cell phenomena, and immunity ,business ,Plasminogen activator - Abstract
Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane-bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers. uPAR levels, however, do not correlate with other components of the plasminogen activator system such as tissue-type plasminogen activator (t-PA), PAI-1 or PAI-2. In addition, uPAR levels showed no correlation with tumor size, axillary-node status or estrogen-receptor status. On the basis of an optimum cut-off point, patients with breast cancers containing high levels of uPAR had a worse prognosis than patients with low levels of the receptor. However, as a prognostic marker in breast cancer, uPAR was not as strong as uPA. Our results are consistent with data from model systems suggesting that both uPA and uPAR are necessary for metastasis. © 1995 Wiley-Liss, Inc.
- Published
- 1995
48. The clinical value of CEA and CA 15-3 in breast cancer management
- Author
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F. Sherry, James J. Fennelly, Enda W. McDermott, J G Geraghty, Michael J. Duffy, N. J. O’Higgins, and E C Coveney
- Subjects
0301 basic medicine ,Cancer Research ,medicine.medical_specialty ,Systemic disease ,Lung Neoplasms ,Time Factors ,Clinical Biochemistry ,Mammary gland ,CA 15-3 ,Bone Neoplasms ,Breast Neoplasms ,Disease ,Gastroenterology ,Pathology and Forensic Medicine ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Carcinoembryonic antigen ,Internal medicine ,medicine ,Humans ,biology ,business.industry ,Liver Neoplasms ,Mucin-1 ,medicine.disease ,Surgery ,Carcinoembryonic Antigen ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,biology.protein ,Clinical value ,Female ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
The value of tumour-associated antigens CEA and CA 15-3 was studied in patients with breast cancer over a 4-year period. A total of 252 patients with primary or recurrent disease had available and corresponding CEA and CA 15-3 values at diagnosis and during follow-up and were studied in detail. Preoperative and three-monthly serial postoperative levels were measured in each patient. Ten of 11 patients presenting with primary and concurrent metastatic disease had elevated CA 15-3 levels (> 25 I.U./ml) as compared to 6 with CEA (> 5 ng/ml). Fourty-seven patients developed locoregional recurrence of which 15 had concurrent metastatic disease. CA 15-3 was elevated in 14 cases while CEA in 11. Of 32 patients with locoregional recurrence alone, 18 later developed metastatic disease at a mean follow-up time of 17.5 months. There was a significant correlation between CA 15-3 value at locoregional recurrence and time to subsequent metastasis (r = 0. -0.57, P = 0.0133). CEA was elevated in 64%, CA 15-3 in 87% and either marker in 94% of 87 patients diagnosed with metastatic disease. Of 53 patients with serial markers and metastatic disease, 72% (38/53) had rising CA 15-3 levels prior to diagnosis with a mean lead time of 9.9 months. Use of CEA in conjunction improved lead time detection to 83%. This study demonstrates that CA 15-3 is superior to CEA at detecting metastatic disease at initial presentation and during follow-up. Use of CEA in conjunction with CA 15-3 improves the detection of systemic disease.
- Published
- 1995
49. Seventeenth sir peter freyer memorial lecture and surgical symposium
- Author
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D. O’Gradaigh, P. J. Byrne, P. Gillen, P. Lawlor, T. N. Walsh, T. P. J. Hennessy, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, H. Li, M. T. P. Caldwell, S. Hone, S. E. A. Attwood, I. P. Kelly, T. P. Corrigan, E. Mulligan, M. J. Kerin, N. N. Williams, K. J. Cronin, M. El Sadar, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, M. Maher, D. Hehir, A. Horgan, R. Stuart, J. A. O’Donnell, M. P. Brady, J. M. O’Donoghue, J. R. Flynn, J. Doyle, M. Gallagher, K. Connolly, M. Barry, M. G Davies, M. West, E. O’Broin, J. A. Connolly, D. Long, M. F. Shine, F. Lennon, K. J. Dawson, J. R. Novell, A. K. Burroughs, K. Rolles, W. P. Joyce, J. Dolan, J. Hyland, O. Traynor, M. Bennett, O. Tighe, H. Mulcahy, D. O’Donoghue, D. Bouchier-Hayes, D. T. Croke, G. Santos, G. Khoury, M. C. Winslet, A. A. M. Lewis, E. Beausang, K. Mealy, L. Joyce, M. McNicholls, D. McErlean, M. A. Stokes, K. Barry, R. Sullivan, J. Byrne, J. Callaghan, T. O’Gorman°, H. F. Given, M. S. Dudeney, M. P. Redmond, J. M. Deasy, V. K. Young, R. G. K. Watson, G. O’Kane, K. Murphy, C. McDowell, K. Khan, S. K. Al-Ghazal, J. McCann, R. C. Stuart, M. O’Connor, J. McCabe, J. O’Byrne, D. O’Farrell, M. Walsh, J. O’Beirne, S. O’Flannagan, A. McGuinness, O. Brady, W. Quinlan, J. P. McCabe, B. Curtin, M. Stephens, J. Stack, P. McCarthy, M. Schnall, H. Pollack, T. H. Lynch, B. Waymont, J. A. Dunn, M. A. Hughes, D. M. A. Wallace, T. E. D. McDermott, R. Grainger, E. Rogers, M. Corcoran, H. Bredin, H. Grimes, D. Lanigan, C. Roobottom, P. A. Dubbins, R. G. Choa, T. Creagh, M. R. Butler, K. J. O’Flynn, R. P. MacDonagh, D. G. Thomas, K. Dawson, J. Aitken, B. Cooke, S. P. Parbhoo, P. M. Cannon, S. C. Low, A. Dixon, I. O. Ellis, C. W. Elston, R. W. Blarney, E. D. Mulligan, K. Cronin, A. Stack, J. Ennis, F. Abbaskoor, M. K. O’Donoghue, G. Fulton, W. A. Tanner, F. B. V. Keane, B. V. Joseph, F. O. Cunningham, M. Dowling, E. Conveney, J. G. Geraghty, P. Byrne, G. Clarke, J. Duffy, N. O’Higgins, D. O’Hanlon, P. G. Horgan, D. O’Brien, C. Phelan, P. Given, P. Kent, S. Sheehan, M. P. Colgan, D. Moore, G. Shanik, P. Murphy, R. Vashisht, M. Sian, P. Franks, M. K. O’Malley, Y. Gul, D. Waldron, W. P. Hederman, H. P. Singh, S. Dias, T. Aherne, D. J. Hehir, J. A. McKeever, C. A. Bannon, D. Mehigan, T. V. Keaveney, T. F. Browne, U. M. Sivananthan, M. R. Rees, S. Whittaker, G. A. Davies, R. Vashisght, E. Sharp, A. Coady, A. Sterpetti, R. M. Greenhalgh, D. P. O’Brien, D. B. Gough, M. C. Regan, I. E. Efron, S. I. Kirk, M. Hurson, H. L. Wasserkrug, A. Barbul, S. Haynes, J. Thornton, J. Sparkes, A. D. K. Hill, C. J. Kelly, J. Gallagher, L. Modyka, H. P. Redmond, J. M. Daly, O. M. Austin, R. J. Cunney, P. A. Grace, C. Curran, J. O’Donoghue, M. Abernathy, N. Sharpe, M. Lucy, E. W. D. McDermott, P. M. Mercer, N. J. O’Higgins, G. Murugasu, A. Groeschel, M. Carmody, J. Donohue, D. H. Osborne, M. McLaughlin, J. Devlin, J. P. Phillips, Y. Ellias, M. Tahir, J. McKeever, M. Tighe, V. Lynch, M. Ahmed, P. P. A. Smyth, A. M. Hetherton, P. Horgan, M. Little, D. S. Quill, C. O. Duncan, M. O’Donnell, J. A. E. Hobby, D. Little, M. Murphy, P. Burke, P. Broe, M. McKiernan, S. J. Kirk, J. Crowe, P. MacMathuna, J. Lennon, T. Corrigan, R. O’Connell, A. Browne, A. Quershi, A. Leahy, G. Courtney, P. Grace, H. Osborne, D. J. Buckley, M. Goggin, T. A. Farrell, J. Geraghty, F. K. Keeling, P. R. O’Connell, H. Naama, E. Moore, E. Barry, C. Duffy, P. Hogan, G. Nee, M. Fahy, D. P. Kenny, V. Ellias, E. Gibney, W. Joyce, E. Gaffney, J. McMahon, M. McCabe, P. Kelly, M. Leader, C. I. Timon, P. Gullane, I. Dardick, I. McCarthy, N. F. Couse, M. Morrin, and P. V. Delaney
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General Medicine - Published
- 1994
- Full Text
- View/download PDF
50. Effect of closing dead space on seroma formation after mastectomy--a prospective randomized clinical trial
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E C, Coveney, P J, O'Dwyer, J G, Geraghty, and N J, O'Higgins
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Chi-Square Distribution ,Shoulder Joint ,Suture Techniques ,Breast Neoplasms ,Exudates and Transudates ,Middle Aged ,Suction ,Surgical Flaps ,Postoperative Complications ,Treatment Outcome ,Surgical Wound Dehiscence ,Humans ,Female ,Prospective Studies ,Range of Motion, Articular ,Mastectomy ,Aged - Abstract
To evaluate the effect of closing dead space on seroma formation after mastectomy, 39 patients undergoing 40 mastectomies with axillary node clearance were randomized to undergo suturing of skin flaps to underlying muscle or conventional skin closure. Duration of closed suction drainage, 72 h, and shoulder exercises, commencing on the first post-operative day, were standardized for both groups. Closed suction drainage was significantly less (P0.05) in the group that had flaps sutured, 272 +/- 46 ml vs 393 +/- 39 ml. Also fewer patients in the flap sutured group developed seromas, 5 (25%) vs 17 (85%) chi 2 = 12.2 P0.001. Three patients in the group that had conventional skin closure had breakdown of wound edges, two developing a prolonged serous discharge, while none occurred in the sutured group. A functional range of shoulder motion was attained at 6 months in 14 (70%) patients in the flap sutured group compared with nine (45%) in the conventional skin closure group (P = NS). These results confirm the value of suturing skin flaps to underlying muscle in reducing local morbidity after mastectomy and suggest that this technique should be included in the closure of all mastectomy wounds.
- Published
- 1993
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