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During the slow neutron capture process in massive stars, reactions on light elements can both produce and absorb neutrons thereby influencing the final heavy element abundances. At low metallicities, the high neutron capture rate of 16-O can inhibit s-process nucleosynthesis unless the neutrons are recycled via the 17O(a,n)20Ne reaction. The efficiency of this neutron recycling is determined by competition between the 17O(a,n)20Ne and 17O(a,g)21Ne reactions. While some experimental data are available on the former reaction, no data exist for the radiative capture channel at the relevant astrophysical energies. The 17O(a,g)21Ne reaction has been studied directly using the DRAGON recoil separator at the TRIUMF Laboratory. The reaction cross section has been determined at energies between 0.6 and 1.6 MeV Ecm, reaching into the Gamow window for core helium burning for the first time. Resonance strengths for resonances at 0.63, 0.721, 0.81 and 1.122 MeV Ecm have been extracted. The experimentally based reaction rate calculated represents a lower limit, but suggests that significant s-process nucleosynthesis occurs in low metallicity massive stars., 7 pages, 5 figures

This Letter reports a study of the highly debated ^{10}Li structure through the d(^{9}Li,p)^{10}Li one-neutron transfer reaction at 100 MeV. The ^{10}Li energy spectrum is measured up to 4.6 MeV and angular distributions corresponding to different excitation energy regions are reported for the first time. The comparison between data and theoretical predictions, including pairing correlation effects, shows the existence of a p_{1/2} resonance at 0.45±0.03 MeV excitation energy, while no evidence for a significant s-wave contribution close to the threshold energy is observed. Moreover, two high-lying structures are populated at 1.5 and 2.9 MeV. The corresponding angular distributions suggest a significant s_{1/2} partial-wave contribution for the 1.5 MeV structure and a mixing of configurations at higher energy, with the d_{5/2} partial-wave contributing the most to the cross section.

The first measurement of inelastic scattering of 9 Li from deuterons at the ISAC facility is reported. The measured angular distribution for the first excited state confirms the nature of excitation to be an E2 transition. The quadrupole deformation parameter is extracted from an analysis of the angular distribution.

Several lifetimes in $^{23}\text{Mg}$ have been determined for the first time using the Doppler-shift attenuation method. A Monte Carlo simulation code has been written to model the $\ensuremath{\gamma}$-ray line shape. An upper limit of $\ensuremath{\tau}l12$ fs at the 95% C.L. has been obtained for the astrophysically important 7787 keV state.

This Letter reports a study of the highly debated ^{10}Li structure through the d(^{9}Li,p)^{10}Li one-neutron transfer reaction at 100 MeV. The ^{10}Li energy spectrum is measured up to 4.6 MeV and angular distributions corresponding to different excitation energy regions are reported for the first time. The comparison between data and theoretical predictions, including pairing correlation effects, shows the existence of a p_{1/2} resonance at 0.45±0.03 MeV excitation energy, while no evidence for a significant s-wave contribution close to the threshold energy is observed. Moreover, two high-lying structures are populated at 1.5 and 2.9 MeV. The corresponding angular distributions suggest a significant s_{1/2} partial-wave contribution for the 1.5 MeV structure and a mixing of configurations at higher energy, with the d_{5/2} partial-wave contributing the most to the cross section.

Although epidemiologic evidence points to cardioprotective activity of red wine, the mechanistic basis for antithrombotic activity has not been established. Quercetin and related flavonoids are present in high concentrations in red but not white wine. Quercetin-glycosides were recently shown to prevent thrombosis in animal models through the inhibition of extracellular protein disulfide isomerase (PDI). We evaluated whether red or white wine inhibited PDI activity in vitro.Quercetin levels in red and white wines were measured by HPLC analysis. Inhibition of PDI activity by red and white wines was assessed by an insulin reduction turbidity assay at various concentrations of wine. PDI inhibition was confirmed using a reduced peptide that contained a disulfide containing peptide as a substrate. The inhibition of PDI related thiol isomerases ERp5 and ERp57 was also assessed.We observed a dose-dependent decrease of PDI activity for a variety of red but not white wines. Red wine diluted to 3% final concentration resulted in over 80% inhibition of PDI activity by insulin reductase assay for all varieties tested. This inhibition was also observed in the peptide based assay. Red grape juice yielded similar results but ethanol alone did not affect PDI activity. Interestingly, red wine also inhibited the PDI related thiol isomerases ERp5 and ERp57, albeit to a lesser degree than PDI.PDI activity is inhibited by red wine and grape juice, identifying a potentially novel mechanism underlying the cardiovascular benefits attributed to wine consumption.

26Al is an important radioisotope in astrophysics that provides evidence of ongoing nucleosynthesis in the Galaxy. The 23Na(α, p)26Mg reaction has been identified by a sensitivity study as being one of the most important reactions for the production of 26Al in the convective C/Ne burning shell of massive stars. Owing to large uncertainties in previous experimental data, model calculations are used for the reaction rate of 23Na(α, p)26Mg in this sensitivity study. Current experimental data suggest a reaction rate a factor of ∼40 higher than model calculations. However, a new measurement of this reaction cross section has been made in inverse kinematics in the energy range E(c.m.)=1.28-3.15 MeV at TRIUMF, and found to be in reasonable agreement with the model calculation. A new reaction rate is calculated and tight constraints on the uncertainty in the production of 26Al, due to this reaction, are determined.

International audience; The changing of the nuclear shells for light, neutron-rich nuclei, and the single-particle nature of 26Na, has been explored by studying 25Na(d, p)26Na in inverse kinematics, using a beam of 25Na ions at 5 MeV per nucleon, provided by the ISAC-II facility at TRIUMF, Vancouver. Charged particles were detected with a highly-segmented silicon array that surrounded the 0.5 mg/cm2 (CD2)n target. Gamma rays from the recoiling 26Na nucleus were detected using eight Compton-suppressed HPGe clover detectors. Recoil tagging was provided by an in-beam scintillation foil, downstream of the germanium array. A novel technique of utilising pγ- and pγγ-gating to extract proton angular distributions from states populated close in energy was employed with success. New states in 26Na that are populated directly have been identified, using γ-decay patterns. Shell model calculations for comparison to experimental results are ongoing, using different model bases.

The first conclusive evidence of a dipole resonance in 11Li having isoscalar character observed from inelastic scattering with a novel solid deuteron target is reported. The experiment was performed at the newly commissioned IRIS facility at TRIUMF. The results show a resonance peak at an excitation energy of 1.03±0.03 MeV with a width of 0.51±0.11 MeV (FWHM). The angular distribution is consistent with a dipole excitation in the distorted-wave Born approximation framework. The observed resonance energy together with shell model calculations show the first signature that the monopole tensor interaction is important in 11Li. The first ab initio calculations in the coupled cluster framework are also included.

26Al is an important radioisotope in astrophysics that provides evidence of ongoing nucleosynthesis in the Galaxy. The 23Na(α, p)26Mg reaction has been identified by a sensitivity study as being one of the most important reactions for the production of 26Al in the convective C/Ne burning shell of massive stars. Owing to large uncertainties in previous experimental data, model calculations are used for the reaction rate of 23Na(α, p)26Mg in this sensitivity study. Current experimental data suggest a reaction rate a factor of ∼40 higher than model calculations. However, a new measurement of this reaction cross section has been made in inverse kinematics in the energy range E(c.m.)=1.28-3.15 MeV at TRIUMF, and found to be in reasonable agreement with the model calculation. A new reaction rate is calculated and tight constraints on the uncertainty in the production of 26Al, due to this reaction, are determined.

The 9Li + 2H → 10Li + 1H one-neutron transfer reaction has been performed at 100 MeV incident energy at TRIUMF using a 9Li beam delivered by the ISAC-II facility. A setup based on double-sided silicon strip detectors has been used in order to detect and identify the outgoing 9Li produced by the 10Li breakup at forward angles and the recoil protons emitted at backward angles. The 10Li low-lying resonances, whose energies, widths and configurations are still unclear, have been populated with significant statistics.

Preliminary studies in preparation for an absolute cross-section measurement of the radiative capture reaction 3 He( α , γ ) 7 Be with the DRAGON recoil separator have demonstrated beam suppression > 10 14 at the 90% confidence level. A measurement of this cross section by observation of 7 Be recoils at the focal plane of the separator should be virtually background free.

At low stellar temperatures the energy release due to the CN cycle is regulated by its slowest reaction ${}^{14}\mathrm{N}(p,\ensuremath{\gamma}){}^{15}\mathrm{O}$, the rate of which strongly depends on the subthreshold resonance at ${E}_{\mathrm{c}}.\mathrm{m}.=\ensuremath{-}504\phantom{\rule{0.28em}{0ex}}\mathrm{keV}$, which corresponds to the 6.79 MeV state in ${}^{15}\mathrm{O}$. By using the Doppler-shift attenuation method and the ${}^{3}\mathrm{He}({}^{16}\mathrm{O},\ensuremath{\alpha}){}^{15}\mathrm{O}$ reaction to populate the state, we obtained an upper limit on the lifetime of this state of $\ensuremath{\tau}l1.8\phantom{\rule{0.28em}{0ex}}\mathrm{fs}$ [68.3% confidence level (C.L.)]. In addition we measured the lifetimes of the 6.18 and 6.86 MeV states to be $\ensuremath{\tau}l2.5$ and $\ensuremath{\tau}=13.{3}_{\ensuremath{-}1.2}^{+0.9}\phantom{\rule{0.28em}{0ex}}\mathrm{fs}$, respectively (68.3% C.L.), in good agreement with the literature.

Objective. To identify the various IPPE designs utilized by US pharmacy programs. Methods. A 20-question survey was developed and distributed to experiential affairs professionals at 129 pharmacy institutions nationwide addressing school demographics and IPPE design. Results were analyzed in aggregate. Results. Ninety-three schools responded (72%). Eighty-nine percent of those reported beginning IPPE experiences in the first professional year, although there was a great variation regarding whether the IPPE was held while didactic classes were in session or during school breaks. The number of required practice experiences varied. Institutions prohibited students from completing rotations in the same pharmacy chain (72%) or hospital (70%) where employed, and from completing 2 rotations at the same site (62%). Fifty-seven percent utilized faculty members as preceptors. 51% allowed a maximum of 2 students per preceptor per practice experience. Conclusion. While clear trends existed in IPPE curricula, institutions incorporated aspects that addressed unique needs. Further research can determine the benefits and drawbacks of different IPPE designs.

The structure of the 10 Li unbound nucleus is a subject of large interest and its description is nowadays a matter of debate. We have investigated this system using the d( 9 Li,p) 10 Li one-neutron transfer reaction at 100 MeV in inverse kinematics. The experiment was performed at the ISACII facility at TRIUMF laboratory. The excitation energy spectrum has been reconstructed by measuring the emitted protons at backward angles and the 9 Li at forward angles.

The 18Ne(α,p) 21Na reaction provides one of the main HCNO-breakout routes into the rp process in x-ray bursts. The 18Ne(α,p0) 21Na reaction cross section has been determined for the first time in the Gamow energy region for peak temperatures T∼2 GK by measuring its time-reversal reaction 21Na(p,α) 18Ne in inverse kinematics. The astrophysical rate for ground-state to ground-state transitions was found to be a factor of 2 lower than Hauser-Feshbach theoretical predictions. Our reduced rate will affect the physical conditions under which breakout from the HCNO cycles occurs via the 18Ne(α,p) 21Na reaction.

The ${}^{17}$O($p,\phantom{\rule{-0.16em}{0ex}}\ensuremath{\gamma}$)${}^{18}$F reaction plays an important role in hydrogen-burning nucleosynthesis. Conflicting values for the low-energy behavior of its cross section exist in the literature. We present direct measurements of the astrophysical $S$ factor of the ${}^{17}$O($p,\phantom{\rule{-0.16em}{0ex}}\ensuremath{\gamma}$)${}^{18}$F reaction at center-of-mass energies between 250 and 500 keV. These measurements were conducted in inverse kinematics at the DRAGON recoil separator.

The 18Ne(α,p) 21Na reaction provides one of the main HCNO-breakout routes into the rp process in x-ray bursts. The 18Ne(α,p0) 21Na reaction cross section has been determined for the first time in the Gamow energy region for peak temperatures T∼2 GK by measuring its time-reversal reaction 21Na(p,α) 18Ne in inverse kinematics. The astrophysical rate for ground-state to ground-state transitions was found to be a factor of 2 lower than Hauser-Feshbach theoretical predictions. Our reduced rate will affect the physical conditions under which breakout from the HCNO cycles occurs via the 18Ne(α,p) 21Na reaction.

4 pags., 2 figs. -- Nuclear Physics in Astrophysics V 3–8 April 2011, Eilat, Israel, We present our initial efforts with the DRAGON separator at TRIUMF facility towards obtaining the energy dependence of the astrophysical S-factor for 3He(¿, ¿)7Be reaction in the energy range of Ecm = 2 to 3 MeV that was recommended by the recent evaluations. A comparison between the existing data and our new complementary Madrid data, together with the recent theoretical calculations, is also given in the context of our ongoing work., This work has been supported by the UK STFC.

Nucleon transfer experiments have in recent years begun to be exploited in the study of nuclei far from stability, using radioactive beams in inverse kinematics. New techniques are still being developed in order to perform these experiments. The present experiment is designed to study the odd-odd nucleus Na which has a high density of states and therefore requires gamma-ray detection to distinguish between them. The experiment employed an intense beam of up to 3×10 pps of Na at 5.0 MeV/nucleon from the ISAC-II facility at triumf. The new silicon array SHARC was used for the first time and was coupled to the segmented clover gamma-ray array TIGRESS. A novel thin plastic scintillator detector was employed at zero degrees to identify and reject reactions occurring on the carbon component of the (CD) target. The efficiency of the background rejection using this detector is described with respect to the proton and gamma-ray spectra from the (d,p) reaction. © Published under licence by IOP Publishing Ltd.

The lowest-energy resonance in the $^{23}\mathrm{Mg}$($p,\ensuremath{\gamma}$)$^{24}\mathrm{Al}$ reaction, which is dominant at classical nova temperatures, has been measured directly for the first time using the DRAGON recoil spectrometer. The experiment used a radioactive $^{23}\mathrm{Mg}$ beam (mixed within a significantly stronger $^{23}\mathrm{Na}$ beam) of peak intensity $5\ifmmode\times\else\texttimes\fi{}{10}^{7}$ $\mathrm{s}{}^{\ensuremath{-}1}$, at the ISAC facility at TRIUMF. We extract values of ${E}_{R}={485.7}_{\ensuremath{-}1.8}^{+1.3}$ keV and $\ensuremath{\omega}\ensuremath{\gamma}={38}_{\ensuremath{-}15}^{+21}$ meV from our data (all values in the center-of-mass frame unless otherwise stated). In addition, the experiment prompted a recalculation of the $Q$ value for this reaction based on a revision of the $^{24}\mathrm{Al}$ mass. The effect on the uncertainties in the quantities of ejected $^{22}\mathrm{Na}$ and $^{26}\mathrm{Al}$ from oxygen-neon classical novae is discussed.

The p({sup 11}Li,{sup 9}Li)t reaction has been studied for the first time at an incident energy of 3A MeV at the new ISAC-2 facility at TRIUMF. An active target detector MAYA, built at GANIL, was used for the measurement. The differential cross sections have been determined for transitions to the {sup 9}Li ground and first excited states in a wide range of scattering angles. Multistep transfer calculations using different {sup 11}Li model wave functions show that wave functions with strong correlations between the halo neutrons are the most successful in reproducing the observation.

The p((11)Li, (9)Li)t reaction has been studied for the first time at an incident energy of 3A MeV at the new ISAC-2 facility at TRIUMF. An active target detector MAYA, built at GANIL, was used for the measurement. The differential cross sections have been determined for transitions to the (9)Li ground and first excited states in a wide range of scattering angles. Multistep transfer calculations using different (11)Li model wave functions show that wave functions with strong correlations between the halo neutrons are the most successful in reproducing the observation.

The ground and low-lying states of the unbound nucleus 10Li were populated by the 9Li + 2H → 10Li + 1H reaction at 11 AMeV incident energy at the ISAC II facility (TRIUMF). In the experimental setup, the outgoing 9Li at forward angles and the recoil protons at backward angles were detected and identified. This setup allows to study the 10Li emitted in the crucial region at forward angles in the centre of mass.

The 9Li + 2H reaction has been investigated at 11 AMeV incident energy at the ISAC II facility (TRIUMF). In the present paper we focus on the one-neutron transfer channel, which potentially holds spectroscopic information on the unbound nucleus 10Li. The TUDA setup has been used in order to detect and identify the outgoing 9Li at forward angles and the recoil protons at backward angles. This setup allows to study the 10Li emitted in the crucial region at forward angles in the center of mass.

International audience; States in 26Na were populated in the (d, pγ) reaction, induced by bombarding deuterium target nuclei with an intense reaccelerated beam of 25Na ions from the ISAC2 accelerator at TRIUMF. Gamma-rays were recorded in coincidence with protons and used to extract differential cross sections for 21 states up to the neutron decay threshold of 5 MeV. Results for levels below 3 MeV are discussed in detail and compared with shell model calculations and with previous work. The angular distributions of decay gamma-rays were measured for individual states and are compared to theoretically calculated distributions, highlighting some issues for future work.

Protein disulfide isomerase (PDI) is a widely expressed oxidoreductase that catalyzes the rearrangement of intramolecular disulfide bonds during protein maturation in the endoplasmic reticulum. However, PDI can also be secreted from both platelets and endothelial cells during thrombus formation. Inhibition of extracellular PDI in the vasculature using neutralizing antibodies or bacitracin blocks thrombus formation in pre-clinical studies. Our previous experiments identified quercetin-3-rutinoside as an inhibitor of PDI and a potent antithrombotic. Recently, we performed a high-throughput screen of the MLSMR library through the Molecular Libraries Probe Production Centers Network (MLPCN) to identify more potent and selective inhibitors of PDI. We now compare the activity of the most potent lead, ML359, to previously described PDI inhibitors and assess its antithrombotic activity. ML359 inhibited the reductase activity of PDI in the insulin turbidometric assay with an IC50 of 0.3-0.6 microM. By comparison, quercetin-3-rutinoside and juniferdin inhibited PDI with IC50s of 6-10 microM, while bacitracin inhibited PDI reductase activity with an IC50 of 100 microM. ML359 demonstrated no confirmed activity at In preparation for pre-clinical studies, further evaluation of the biophysical properties of ML359 was performed. ML359 demonstrated acceptable solubility in PBS, human plasma and GSH. However, it showed poor stability in mouse plasma as well as in presence of liver microsomes. To optimize and improve these biophysical properties of the ML359, over 85 analogs of the lead were synthesized. Modulation of the ethyl substituent of the ester group with bulky isopropyl or t-butyl substituents increased the mouse plasma stability from ∼5% in ML359 to ∼75% and ∼95% in the analogs, respectively. These substitutions only minimally altered the potency of the compound (0.6-0.9 microM). The ML359 analogs demonstrated increased inhibitory activity in platelet aggregation assays, with inhibition at 30 microM increasing from 25% for ML359 to 97 and 100% for the isopropyl and t-butyl substituted analogs, respectively. The ability of ML359 to prevent thrombus formation in a laser injury mouse model was examined. Thrombus formation was monitored following laser injury of cremaster arterioles and the effect of ML359 infusion on platelet accumulation evaluated. ML359 exposure resulted in a significantly smaller thrombus that that observed in the animals infused with vehicle alone. ML359 and its active analogs have enhanced properties compared to the first generation PDI antagonists. These compounds are substantially more potent than previously described PDI inhibitors such as bacitracin and show significant potential as second generation inhibitors to probe PDI function in biological systems. ML359 analogs could ultimately be developed as antithrombotics that target PDI. Disclosures: No relevant conflicts of interest to declare.

The s-wave neutron fraction of the 0 + levels in 12Be has been investigated for the first time through the 11Be( d , p ) transfer reaction using a 5 A MeV 11Be beam at TRIUMF, Canada. The reaction populated all the known bound states of 12Be. The ground state s-wave spectroscopic factor was determined to be 0.28 − 0.07 + 0.03 while that for the long-lived 0 2 + excited state was 0.73 − 0.40 + 0.27 . This observation, together with the smaller effective separation energy indicates enhanced probability for an extended density tail beyond the 10Be core for the 0 2 + excited state compared to the ground state.

The first measurement of the one-neutron transfer reaction 11Li(p,d)10Li performed using the IRIS facility at TRIUMF with a 5.7A MeV 11Li beam interacting with a solid H2 target is reported. The 10Li residue was populated strongly as a resonance peak with energy Er=0.62±0.04 MeV having a total width Γ=0.33±0.07 MeV. The angular distribution of this resonance is characterized by neutron occupying the 1p1/2 orbital. A DWBA analysis yields a spectroscopic factor of 0.67±0.12 for p1/2 removal strength from the ground state of 11Li to the region of the peak. Keywords: Halo nucleus, Li10,11, Transfer reaction, Inverse kinematics, DWBA, Spectroscopic factor