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Your search keyword '"N. G. Tsyshkova"' showing total 26 results
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26 results on '"N. G. Tsyshkova"'

2. Antimetastatic effects of arbidol, a new antiviral drug

Author

A. M. Poverennyi, N. G. Tsyshkova, A. F. Tsyb, and E. O. Fedorovskaya

Subjects
Transplantation, medicine.drug_class, Interferon, business.industry, medicine, General Medicine, PULMONARY CARCINOMA, Antiviral drug, Pharmacology, business, Virology, General Biochemistry, Genetics and Molecular Biology, medicine.drug
Abstract

Arbidol, a new antiviral drug, is found to suppress metastases of Lewis' pulmonary carcinoma for various methods of transplantation. The effects of arbidol are compatible with those of the standard interferon inductor poly-I-poly-C.

Published
1994

3. Study of metabolism of14C-arbidole

Author

O. S. Anisimova, E. P. Savina, F. A. Trofimov, V. G. Skvortsov, V. A. Yadrovskaya, N. G. Tsyshkova, and A. N. Dedenkov

Subjects
Pharmacology, Chemistry, business.industry, Environmental chemistry, Drug Discovery, Pharmacology toxicology, Pharmacy, Metabolism, business
Published
1993

6. Synthesis of a new antiviral agent, arbidole

Author

N. G. Tsyshkova, S. A. Zotova, A. N. Grinev, and F. A. Trofimov

Subjects
Pharmacology, business.industry, Chemistry, Drug Discovery, Pharmacology toxicology, Organic chemistry, Pharmacy, business
Published
1993

7. A study of the intramolecular cyclization of esters of 3-arylazoindol-2-ylacetic acids

Author

V. I. Garnova, N. G. Tsyshkova, and F. A. Trofimov

Subjects
Indole test, Chemistry, Intramolecular force, Organic Chemistry, Condensation, Intramolecular cyclization, Organic chemistry
Abstract

A method is proposed for the synthesis of the new heterocyclic system pyridazino-[4,3-b]indole which is based on the intramolecular condensation of ethyl 3-arylazoindol-2-ylacetates in the presence of bases.

Published
1985

9. Condensation of arylsulfonyl-p-benzoquinones with imines of ?-dicarbonyl compounds

Author

F. A. Trofimov, A. N. Grinev, T. F. Vlasova, and N. G. Tsyshkova

Subjects
Indole test, chemistry.chemical_compound, chemistry, Organic Chemistry, Condensation, P-Benzoquinones, Benzofuran, Medicinal chemistry, Adduct
Abstract

Adducts of 2-arylsulfonyl-p-benzoquinones with imines of β-dicarbonyl compounds were obtained and their conversions to indole and benzofuran derivatives were studied.

Published
1976

10. Studies of quinones

Author

F. A. Trofimov, N. G. Tsyshkova, K. S. Shadurskii, T. I. Mukhanova, and A. N. Grinev

Subjects
Pharmacology, Chemistry, Drug Discovery, Pharmacology toxicology, Organic chemistry
Published
1967

12. Synthesis of isotryptamines and tetrahydro-?-carbolines from 2-indolylacetic acid derivatives

Author

V. I. Garnova, N. G. Tsyshkova, A. N. Grinev, and F. A. Trofimov

Subjects
chemistry.chemical_compound, Sodium borohydride, chemistry, Organic Chemistry, Condensation, Formaldehyde, Organic chemistry
Abstract

The reaction of ethyl 2-indolylacetate with alkylamines gave the corresponding amides, which were reduced with sodium borohydride to isotryptamines. The latter were converted to 1,2,3,4-tetrahydro-γ-carboline derivatives by condensation with formaldehyde.

Published
1979

13. ?-Methylthioacetoacetic ester in the synthesis of 2-indolylacetic acid derivatives

Author

N. G. Tsyshkova, F. A. Trofimov, A. N. Grinev, and V. I. Garnova

Subjects
Acid derivative, Chemistry, Organic Chemistry, Acetoacetic ester synthesis, Condensation, Organic chemistry
Abstract

A new method is proposed for the synthesis of 2-indolylacetic acid derivatives with a free β position by condensation of an alkyl-thioacetoacetic ester with arylhydrazines. Some of the reactions of the acids obtained were investigated.

Published
1975

14. Pyridylethylation ofγ-carbolines

Author

N. G. Tsyshkova, F. A. Trofimov, E. V. Vinogradova, A. N. Kost, and K. S. Shadurskii

Subjects
Pharmacology, Indole test, Nitrogen atom, Group (periodic table), Chemistry, Drug Discovery, Pharmacology toxicology, Organic chemistry
Abstract

The synthesis of a series of derivatives of 1,2,3,4-tetrahydro-λ-carbolines having a 2- or a 4-pyridylethyl group on the indole nitrogen atom is described.

Published
1967

15. ChemInform Abstract: CONDENSATION OF ARYLSULFONYL-P-BENZOQUINONES WITH IMINES OF β-DICARBONYL COMPOUNDS

Author

N. G. Tsyshkova, F. A. Trofimov, A. N. Grinev, and T. F. Vlasova

Subjects
Indole test, chemistry.chemical_compound, chemistry, Condensation, P-Benzoquinones, General Medicine, Benzofuran, Medicinal chemistry, Adduct
Abstract

Adducts of 2-arylsulfonyl-p-benzoquinones with imines of β-dicarbonyl compounds were obtained and their conversions to indole and benzofuran derivatives were studied.

Published
1976

25. Investigation in the field of quinones

Author

F. A. Trofimov, A. N. Grinev, V. I. Nozdrich, and N. G. Tsyshkova

Subjects
Pharmacology, Indole test, chemistry.chemical_compound, Chemistry, Aryl, Drug Discovery, Pharmacology toxicology, Organic chemistry, Sulfate, Quinone
Abstract

1. A series of 1-alkyl(aryl)-2-methyl-3-carbethoxy-4,5-dioxo-7-dimethylaminoindoles was obtained by oxidative animation of 5-hydroxyindole derivatives. 2. Monoarylhydrazones of 1-alkyl (aryl)-2-methyl-3-carbethoxy-4,5,6,7-tetraoxoindoles were prepared by the reaction of dimethylaminoquinones of the indole acidic salts in aryldiazonium series with medium. 3. It was established that the reaction of 1,2-dimethyl-3-carbethoxy-4,5-dioxo-7-dimethylaminoindole with o-nitrophenyldiazonium sulfate at pH 7.0–8.0 leads to the aryldimethylaminoquinone.

Published
1971

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