24 results on '"N. Eisner"'
Search Results
2. The SATCHEL pipeline: A general tool for data classified through citizen science
- Author
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E J Safron, T S Boyajian, and N Eisner
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Earth and Planetary Astrophysics (astro-ph.EP) ,Science & Technology ,detection [planets and satellites] ,KEPLER ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astronomy & Astrophysics ,Space and Planetary Science ,DISCOVERY ,Physical Sciences ,data analysis [methods] ,GALAXY ZOO ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,PLANET HUNTERS TESS ,CANDIDATES ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Citizen science is a powerful analysis tool, capable of processing large amounts of data in a very short time. To bridge the gap between classification data products from web-based citizen science platforms to statistically robust signal significance scores, we present the Search Algorithm for Transits in the Citizen science Hunt for Exoplanets in Lightcurves (SATCHEL) pipeline. This open source, customizable pipeline was constructed to identify and assign significance estimates to one-dimensional features marked by volunteers. We describe the functional capabilities of the SATCHEL pipeline through application to features in photometric time-series data from the Kepler Space Telescope, classified by volunteers as part of the Planet Hunters citizen science project hosted on the Zooniverse platform. We evaluate the SATCHEL pipeline's overall performance based on recovery of known signals (both simulations and signals corresponding to official Kepler Objects of Interest) and relative contamination by spurious features. We find that, for a range of pipeline hyperparameters and with a reasonable score cutoff, SATCHEL is able to recover volunteer identifications of over 98% of signals from simulations corresponding to exoplanets $>2~R_\oplus$ in radius and about 85% of signals corresponding to the same size range of KOIs. SATCHEL is transparently adaptable to other citizen science classification datasets, and available on GitHub., 20 pages, 23 figures. Accepted for publication in MNRAS
- Published
- 2022
- Full Text
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3. The young HD 73583 (TOI-560) planetary system: Two 10-M⊕ mini-Neptunes transiting a 500-Myr-old, bright, and active K dwarf
- Author
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O Barragán, D J Armstrong, D Gandolfi, I Carleo, A A Vidotto, C Villarreal D’Angelo, A Oklopčić, H Isaacson, D Oddo, K Collins, M Fridlund, S G Sousa, C M Persson, C Hellier, S Howell, A Howard, S Redfield, N Eisner, I Y Georgieva, D Dragomir, D Bayliss, L D Nielsen, B Klein, S Aigrain, M Zhang, J Teske, J D Twicken, J Jenkins, M Esposito, V Van Eylen, F Rodler, V Adibekyan, J Alarcon, D R Anderson, J M Akana Murphy, D Barrado, S C C Barros, B Benneke, F Bouchy, E M Bryant, R P Butler, J Burt, J Cabrera, S Casewell, P Chaturvedi, R Cloutier, W D Cochran, J Crane, I Crossfield, N Crouzet, K I Collins, F Dai, H J Deeg, A Deline, O D S Demangeon, X Dumusque, P Figueira, E Furlan, C Gnilka, M R Goad, E Goffo, F Gutiérrez-Canales, A Hadjigeorghiou, Z Hartman, A P Hatzes, M Harris, B Henderson, T Hirano, S Hojjatpanah, S Hoyer, P Kabáth, J Korth, J Lillo-Box, R Luque, M Marmier, T Močnik, A Muresan, F Murgas, E Nagel, H L M Osborne, A Osborn, H P Osborn, E Palle, M Raimbault, G R Ricker, R A Rubenzahl, C Stockdale, N C Santos, N Scott, R P Schwarz, S Shectman, S Seager, D Ségransan, L M Serrano, M Skarka, A M S Smith, J Šubjak, T G Tan, S Udry, C Watson, P J Wheatley, R West, J N Winn, S X Wang, A Wolfgang, C Ziegler, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Ministerio de Ciencia e Innovación (España), European Commission, European Research Council, Swiss National Science Foundation, Fondazione Cassa di Risparmio di Torino, Centre National D'Etudes Spatiales (France), and Low Energy Astrophysics (API, FNWI)
- Subjects
Earth and Planetary Astrophysics (astro-ph.EP) ,Stars: activity ,Planets and satellites: individual: HD 73583 (TOI-560) ,radial velocities [Techniques] ,photometric [Techniques] ,FOS: Physical sciences ,Astronomy and Astrophysics ,Q1 ,individual: HD 73583 (TOI-560) [Planets and satellites] ,Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,[SDU]Sciences of the Universe [physics] ,Techniques: radial velocities ,activity [Stars] ,Solar and Stellar Astrophysics (astro-ph.SR) ,Techniques: photometric ,QB ,Astrophysics - Earth and Planetary Astrophysics - Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.--Full list of authors: Barragan, O.; Armstrong, D. J.; Gandolfi, D.; Carleo, I; Vidotto, A. A.; D'Angelo, C. Villarreal; Oklopcic, A.; Isaacson, H.; Oddo, D.; Collins, K.; Fridlund, M.; Sousa, S. G.; Persson, C. M.; Hellier, C.; Howell, S.; Howard, A.; Redfield, S.; Eisner, N.; Georgieva, I. Y.; Dragomir, D.; Bayliss, D.; Nielsen, L. D.; Klein, B.; Aigrain, S.; Zhang, M.; Teske, J.; Twicken, J. D.; Jenkins, J.; Esposito, M.; Van Eylen, V.; Rodler, F.; Adibekyan, V; Alarcon, J.; Anderson, D. R.; Murphy, J. M. Akana; Barrado, D.; Barros, S. C. C.; Benneke, B.; Bouchy, F.; Bryant, E. M.; Butler, R. P.; Burt, J.; Cabrera, J.; Casewell, S.; Chaturvedi, P.; Cloutier, R.; Cochran, W. D.; Crane, J.; Crossfield, I; Crouzet, N.; Collins, K., I; Dai, F.; Deeg, H. J.; Deline, A.; Demangeon, O. D. S.; Dumusque, X.; Figueira, P.; Furlan, E.; Gnilka, C.; Goad, M. R.; Goffo, E.; Gutierrez-Canales, F.; Hadjigeorghiou, A.; Hartman, Z.; Hatzes, A. P.; Harris, M.; Henderson, B.; Hirano, T.; Hojjatpanah, S.; Hoyer, S.; Kabath, P.; Korth, J.; Lillo-Box, J.; Luque, R.; Marmier, M.; Mocnik, T.; Muresan, A.; Murgas, F.; Nagel, E.; Osborne, H. L. M.; Osborn, A.; Osborn, H. P.; Palle, E.; Raimbault, M.; Ricker, G. R.; Rubenzahl, R. A.; Stockdale, C.; Santos, N. C.; Scott, N.; Schwarz, R. P.; Shectman, S.; Seager, S.; Segransan, D.; Serrano, L. M.; Skarka, M.; Smith, A. M. S.; Subjak, J.; Tan, T. G.; Udry, S.; Watson, C.; Wheatley, P. J.; West, R.; Winn, J. N.; Wang, S. X.; Wolfgang, A.; Ziegler, C.; KESPRINT Team., We present the discovery and characterization of two transiting planets observed by TESS in the light curves of the young and bright (V = 9.67) star HD73583 (TOI-560). We perform an intensive spectroscopic and photometric space- and ground-based follow-up in order to confirm and characterize the system. We found that HD73583 is a young (∼500 Myr) active star with a rotational period of 12.08 ± 0.11 d, and a mass and radius of 0.73 ± 0.02 M⊙ and 0.65 ± 0.02 R⊙, respectively. HD 73583 b (Pb = 6.3980420+0.0000067−0.0000062 d) has a mass and radius of 10.2+3.4−3.1 M⊕ and 2.79 ± 0.10 R⊕, respectively, which gives a density of 2.58+0.95−0.81 gcm−3. HD 73583 c (Pc = 18.87974+0.00086−0.00074 d) has a mass and radius of 9.7+1.8−1.7 M⊕ and 2.39+0.10−0.09 R⊕, respectively, which translates to a density of 3.88+0.91−0.80 gcm−3. Both planets are consistent with worlds made of a solid core surrounded by a volatile envelope. Because of their youth and host star brightness, they both are excellent candidates to perform transmission spectroscopy studies. We expect ongoing atmospheric mass-loss for both planets caused by stellar irradiation. We estimate that the detection of evaporating signatures on H and He would be challenging, but doable with present and future instruments. © The Author(s) 2022. Published by Oxford University Press on behalf of Royal Astronomical Society., This work was supported by the KESPRINT collaboration, an international consortium devoted to the characterization and research of exoplanets discovered with space-based missions (http://www.kesprint.science). We thank the referee for their helpful comments and suggestions that improved the quality of this manuscript. We acknowledge the use of public TESS data from pipelines at the TESS Science Office and at the TESS Science Processing Operations Center. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Advanced Supercomputing (NAS) Division at Ames Research Center for the production of the SPOC data products. This work uses observations from the LCOGT network. Part of the LCOGT telescope time was granted by NOIRLab through the Mid-Scale Innovations Program (MSIP). MSIP is funded by NSF. This paper is in part based on data collected under the NGTS project at the ESO La Silla Paranal Observatory. The NGTS facility is operated by the consortium institutes with support from the UK Science and Technology Facilities Council (STFC) projects ST/M001962/1 and ST/S002642/1. This research has used the NASA Exoplanet Archive, which is operated by the California Institute of Technology, under contract with the National Aeronautics and Space Administration under the Exoplanet Exploration Program. Some of the observations in the paper used the High-Resolution Imaging instrument Zorro obtained under Gemini LLP Proposal Number: GN/S-2021A-LP-105. Zorro was funded by the NASA Exoplanet Exploration Program and built at the NASA Ames Research Center by Steve B. Howell, Nic Scott, Elliott P. Horch, and Emmett Quigley. Zorro was mounted on the Gemini North (and/or South) telescope of the international Gemini Observatory, a program of NSF’s OIR Lab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation on behalf of the Gemini partnership: the National Science Foundation (United States), National Research Council (Canada), Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología e Innovación (Argentina), Ministério da Ciência, Tecnologia, Inovações e Comunicações (Brazil), and Korea Astronomy and Space Science Institute (Republic of Korea). OB, BK, and SA acknowledge that this publication is part of a project that has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 865624). DG and LMS gratefully acknowledge financial support from the Cassa di Risparmio di Torino foundation under Grant No. 2018.2323 ‘Gaseous or rocky? Unveiling the nature of small worlds’. DJA acknowledges support from the STFC via an Ernest Rutherford Fellowship (ST/R00384X/1). APH and ME acknowledges grant HA 3279/12-1 within the DFG Schwerpunkt SPP 1992, ‘Exploring the Diversity of Extrasolar Planets’. JS and PK would like to acknowledge support from MSMT grant LTT-20015. We acknowledges the support by FCT – Fundação para a Ciência e a Tecnologia through national funds and by FEDER through COMPETE2020 – Programa Operacional Competitividade e Internacionalização by these grants: UID/FIS/04434/2019; UIDB/04434/2020; UIDP/04434/2020; PTDC/FIS-AST/32113/2017 & POCI-01-0145-FEDER-032113; PTDC/FISAST /28953/2017 & POCI-01-0145-FEDER-028953. AD acknowledges the financial support of the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (project FOUR ACES; grant agreement No 724427). AD also acknowledges financial support of the the Swiss National Science Foundation (SNSF) through the National Centre for Competence in Research ‘PlanetS’. MF, IYG, JK, and CMP gratefully acknowledge the support of the Swedish National Space Agency (DNR 177/19, 174/18, 2020-00104, 65/19). FGC thanks the Mexican national council for science and technology (CONACYT, CVU-1005374). MS acknowledge financial support of the Inter-transfer grant no LTT-20015. JL-B acknowledges financial support received from ‘la Caixa’ Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 847648, with fellowship code LCF/BQ/PI20/11760023. AAV acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 817540, ASTROFLOW). JMAM is supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1842400. JMAM acknowledges the LSSTC Data Science Fellowship Program, which is funded by LSSTC, NSF Cybertraining Grant No. 1829740, the Brinson Foundation, and the Moore Foundation; his participation in the program has benefited this work. RAR is supported by the NSF Graduate Research Fellowship, grant No. DGE 1745301. RL acknowledges financial support from the Spanish Ministerio de Ciencia e Innovación, through project PID2019-109522GB-C52, and the Centre of Excellence ‘Severo Ochoa’ award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709). PC acknowledges the generous support from Deutsche Forschungsgemeinschaft (DFG) of the grant CH 2636/1-1. SH acknowledges CNES funding through the grant 837319. VA acknowledges the support from Fundação para a Ciência e Tecnologia (FCT) through Investigador FCT contract nr. IF/00650/2015/CP1273/CT0001. ODSD is supported in the form of work contract (DL 57/2016/CP1364/CT0004) funded by national funds through Fundação para a Ciência e Tecnologia (FCT). AO is supported by an STFC studentship. XD would like to acknowledge the funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement SCORE No 851555). HJD acknowledges support from the Spanish Research Agency of the Ministry of Science and Innovation (AEI-MICINN) under the grant ‘Contribution of the IAC to the PLATO Space Mission’ with reference PID2019-107061GB-C66, DOI: 10.13039/501100011033. DD acknowledges support from the TESS Guest Investigator Program grant 80NSSC19K1727 and NASA Exoplanet Research Program grant 18-2XRP18_2-0136. AO gratefully acknowledges support from the Dutch Research Council NWO Veni grant.
- Published
- 2022
4. Traitement des matières de vidange par lits de séchage plantés de roseaux et valorisation des percolats en bois énergie : une approche écologique
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Boram Kim, Pascal Molle, J. Di Mare, T. Bel, N. Eisner, J.Y. Fraysse, P. Bourdoncle, B. Molle, S. Troesch, Kim, Boram, Ouvrages hydrauliques et hydrologie (UR OHAX), Centre national du machinisme agricole, du génie rural, des eaux et forêts (CEMAGREF), Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), COMMUNAUTE DE COMMUNES TERRASSES ET VALLER DE L'AVEYRON CCTVA NEGREPELISSE FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), EPUR NATURE CAUMONT SUR DURANCE FRA, Gestion de l'Eau, Acteurs, Usages (UMR G-EAU), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut Technologique Forêt Cellulose Bois-construction Ameublement (FCBA), SATESE 82 MONTAUBAN FRA, and Agence de l'Eau Adour-Garonne
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Fluid Flow and Transfer Processes ,[CHIM.ANAL] Chemical Sciences/Analytical chemistry ,[SDE.IE]Environmental Sciences/Environmental Engineering ,[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,[SDE.MCG]Environmental Sciences/Global Changes ,0207 environmental engineering ,Ocean Engineering ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,[SDE.MCG] Environmental Sciences/Global Changes ,[CHIM.ANAL]Chemical Sciences/Analytical chemistry ,[SDE]Environmental Sciences ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,[SDE.IE] Environmental Sciences/Environmental Engineering ,020701 environmental engineering ,General Agricultural and Biological Sciences ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,Water Science and Technology - Abstract
International audience; La gestion pérenne des déchets issus de l'assainissement passe par des solutions adaptées au contexte des territoires. Elle doit notamment respecter les principes de proximité dans les circuits de collecte et traitement et permettre au mieux la valorisation des déchets. L'unité de traitement des matières de vidange de Nègrepelisse répond à ces impératifs avec une solution écologique qui offre plusieurs avantages : - sobriété énergétique dans les transports induits avec un site proche des déchets à éliminer, et dans la consommation énergétique de la filière extensive de traitement mise en ½uvre - valorisation énergétique vers une filière bois-énergie locale, - intégration paysagère avec une filière qui se fond dans le paysage environnant. - durabilité du système technique et agronomique. Le travail a consisté à suivre les performances de la filière dans son ensemble : traitements des effluents, distribution sur la parcelle et son homogénéité et valorisation des eaux usées traitées par la croissance des arbres sur une période de trois saisons d'irrigation. L'objectif était de valider la filière de traitement ainsi que de tester plusieurs modalités de conduite des irrigations afin de montrer que cette filière est très performante tant en terme de finalisation du traitement de l'effluent que de valorisation par la production de bois sans impacter le milieu.
- Published
- 2016
5. Modeling global water use for the 21st century
- Author
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Wada, Y.; Flörke, M.; Hanasaki, N.; Eisner, S.; Fischer, G.; Tramberend, S.; Satoh, Y.; van Vliet, M. T. H.; Yillia, P.; Ringler, Claudia; Burek, P.; Wiberg, D., http://orcid.org/0000-0002-8266-0488 Ringler, Claudia, Wada, Y.; Flörke, M.; Hanasaki, N.; Eisner, S.; Fischer, G.; Tramberend, S.; Satoh, Y.; van Vliet, M. T. H.; Yillia, P.; Ringler, Claudia; Burek, P.; Wiberg, D., and http://orcid.org/0000-0002-8266-0488 Ringler, Claudia
- Abstract
PR, IFPRI3; ISI; CRP5; A Ensuring Sustainable food production, EPTD, CGIAR Research Program on Water, Land and Ecosystems (WLE)
- Published
- 2016
6. Surgical management of decubitus ulcers
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Mark S. Granick, Anita N. Eisner, and Mark P. Solomon
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Pressure Ulcer ,Wound Healing ,medicine.medical_specialty ,business.industry ,Incidence ,Public health ,Staffing ,Skin Transplantation ,Dermatology ,Surgical Flaps ,Surgery ,Risk Factors ,Treatment modality ,Epidemiology ,Health care ,Prevalence ,Etiology ,Humans ,Medicine ,business ,Intensive care medicine ,Hospital stay ,health care economics and organizations ,Neurologically impaired - Abstract
Decubitus ulcers are a significant source of morbidity and mortality in those populations affected 1–3 : the elderly, the neurologically impaired, and paraplegics. Health care expenditures rise because of the increased length of hospital stay for patients with pressure ulcers. Treatment modalities and staffing time are increased considerably with the management of pressure ulcers both in the United States 1,4 and abroad. 5 The magnitude of the decubitus ulcer problem has been compared to an epidemic in the British literature, 5 and it is considered a serious public health concern by authorities in the United States. 4,6 The literature abounds with reviews focusing on the epidemiology, etiology, pathophysiology, risk factors, prevention, and treatment of decubitus ulcers. 5–12 These aspects are addressed in this article to provide a clear understanding of the populations at risk for developing decubitus ulcers and of those pathophysiologic factors responsible for their development. Subsequently, preventive measures, management, and treatment modalities are discussed.
- Published
- 1994
7. 550 Nupharidine inhibits NF-kB activity, induces apoptosis and has synergistic cytotoxic activity with cisplatin and etoposide
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Jacob Gopas, Daniel Benharroch, Janet Ozer, N. Eisner, and Avi Golan-Goldhirsh
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Cisplatin ,Cancer Research ,Oncology ,Apoptosis ,Chemistry ,medicine ,Cancer research ,Cytotoxic T cell ,Etoposide ,medicine.drug - Published
- 2014
8. A motional stark effect instrument to measure q(R) on the C-mod tokamak
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N. Bretz, J.L. Terry, H. Yuh, Earl Marmar, N. Eisner, D. Simon, William L. Rowan, R. Parsells, R. V. Bravenec, and M. B. Sampsell
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Physics ,Tokamak ,Optical fiber ,business.industry ,Polarization (waves) ,law.invention ,symbols.namesake ,Optics ,Stark effect ,law ,symbols ,Plasma diagnostics ,Vacuum chamber ,Emission spectrum ,Optical filter ,business ,Instrumentation - Abstract
A motional Stark effect (MSE) instrument to measure q(r) using the Torus Experiment for Technology (TEXT) neutral beam on the Alcator C-Mod tokamak has been designed and installed. The neutral beam is on the midplane, aimed radially, and designed to operate in hydrogen at 50 keV. The MSE optics view the outer half of the plasma −0.3
- Published
- 2001
9. The relationship between deepwater deposition and an active accretionary wedge, ultra deep water Trinidad
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Dewi Jones, Mo Etemadi, Jean Gerard, Laszlo Benkovic, Luis Anzulovich, and Pablo N. Eisner
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Sedimentary depositional environment ,geography ,geography.geographical_feature_category ,Accretionary wedge ,Continental shelf ,Clastic rock ,Facies ,Geochemistry ,Overbank ,Diapir ,Geomorphology ,Geology ,Salt tectonics - Abstract
The Trinidad Ultra-deepwater (UDW) area lies on today’s continental slope off the eastern coast of Trinidad; it overlies oceanic crust and is part the Barbados Fold Belt, an active accretionary prism. See Figure 1 for location. Sedimentation has been rapid due to the constant feeding of clastic material from the Orinoco River. Figure 2 is a cross section that shows the relationship between the Columbus Basin extension and the active thrusting. In the area, deepwater turbidite sands are interbedded with shales, possibly providing both reservoir and seals. Deepwater channels and lobes have been identified and mapped in the existing 2D seismic. There are 13 wells that reached up to the lowest Pliocene, immediately to the west of the UDW area, providing a direct tie to the seismic stratigraphy interpretation. Figure 3 shows an E-W oriented seismic section showing the active thrusting and shale dome interaction. Priority for reservoir investigation was given to the late Middle Miocene to Pliocene, if only because deeper sections are increasingly overpressured and therefore difficult and risky to drill. Clastic composition and texture are interpreted to be mature, with mainly quartzose sands of continental affinity, consisting of amalgamated sand in the lobes and fine sand/silt interbedded with silty shales, in predominantly distal turbidites or overbank deposits. Minibasin deposition shown in Figure 4 is comparable in general terms with deepwater Gulf of Mexico lows created by salt tectonics. Most of the structures identified in the UDW area were active during the Upper Miocene and Plio-Pleistocene, so no areas are expected to show sheet like, unconfined basin floor fans. The ongoing development of the accretionary wedge will have focused sediments in a NNE-direction, in contrast to the SW-NE basinal axis trends which would dominate slightly older sediments. The growth of mud diapirs, probably initiated in the Plio-Pleistocene as increased amount of sediments were deposited further complicated the depositional pattern. Turbidite deposition of Upper and Middle Miocene age is interpreted to be of distal fans facies, while in the Plio-Pleistocene, they respond more to a minibasin setting and channellevee facies.
- Published
- 2008
10. Velocity model building in Shale Diapir provinces, examples from the Reforma‐Comalcalco Sub basin, Southern Mexico
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Jorge San Martín Romero, Alex Ababio, Carlos Barajas Llerenas, Karen Romand, Hugo Martinez, Craig Docherty, Pablo N. Eisner, Doug Allinson, and Julio Cerrillo
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Geochemistry ,Structural basin ,Diapir ,Model building ,Geomorphology ,Oil shale ,Geology - Published
- 2004
11. 729: Nupharidine inhibits NF-kappa B activity, has synergistic cytotoxic activity with cisplatin and etoposide and induces apoptosis
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Janet Ozer, Jacob Gopas, Daniel Benharroch, N. Eisner, and Avi Golan-Goldhirsh
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Cisplatin ,Cancer Research ,Oncology ,Apoptosis ,Chemistry ,Cancer research ,medicine ,Cytotoxic T cell ,NFKB1 ,Etoposide ,medicine.drug - Published
- 2014
12. Laboratory Facility for Ionospheric Reaction Studies
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P. N. Eisner, J. A. Slevin, and M. N. Hirsh
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Physics ,Electron density ,Electron ,Irradiation ,Diffusion (business) ,Radiation ,Atomic physics ,Neutral particle ,Instrumentation ,Afterglow ,Ion - Abstract
This paper describes techniques employed in the laboratory investigation of charged and neutral particle reactions of importance in the ionosphere. Atmospheric gases at densities appropriate to the D region, contained in a large reaction chamber, are irradiated by a spatially uniform flux of 1.5 MeV electrons. The resulting reactions are studied by a combination of resonant cavity measurements of electron density, mass analysis of positive and negative ions, and optical emission spectroscopy, both during continuous beam irradiation of the gas and in the radiation afterglow. Mechanisms and rates for molecular production and loss processes have been investigated using this apparatus under conditions resembling those in the ionosphere, with negligible competition from diffusion losses to the container walls. In addition to descriptions of the techniques, the paper includes examples of measurements made with the experimental system.
- Published
- 1968
13. Ionization and Attachment inO2and AirlikeN2:O2Mixtures Irradiated by 1.5-MeV Electrons
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M. N. Hirsh, P. N. Eisner, and J. A. Slevin
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Materials science ,chemistry ,Ionization ,Electron attachment ,General Physics and Astronomy ,chemistry.chemical_element ,Molecule ,Electron ,Irradiation ,Atomic physics ,Oxygen - Published
- 1969
14. An Electron Gun For Atomic Beam Recoil Scattering Experiments
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B. B. Aubrey, P. N. Eisner, R. J. Celotta, and R. E. Collins
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Physics ,Range (particle radiation) ,Reflection high-energy electron diffraction ,Recoil ,Scattering ,Electron capture ,Atomic physics ,Mott scattering ,Electron beam-induced deposition ,Instrumentation ,Electron gun - Abstract
A versatile low energy electron gun suitable for electron‐atom scattering experiments has been designed utilizing photoetched grids and precision ceramic spacers which stack onto ceramic rods. Diagnostic techniques are described which determine the absolute electron energy to within ±0.1 eV. Electron guns which operate over the energy range 0.1–25 eV with currents up to 10 mA and energy spreads as low as 0.2 eV have been built using the design presented here.
- Published
- 1970
15. Laboratory Measurements of Ion Chemistry in a Simulated Disturbed Ionosphere
- Author
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M. N. Hirsh and P. N. Eisner
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Chemistry ,Analytical chemistry ,chemistry.chemical_element ,Ionic bonding ,Electron ,Condensed Matter Physics ,Mass spectrometry ,Oxygen ,Ion ,Reaction rate constant ,Torr ,General Earth and Planetary Sciences ,Irradiation ,Electrical and Electronic Engineering ,Atomic physics - Abstract
We present experimental results from a partial simulation of the disturbed nighttime ionosphere at 300°K. N2:O2 mixtures at pressures from 0.1 to 30 torr are contained in a 700-liter chamber and irradiated by a diffuse beam of megavolt electrons. In dry gas, only the ions O2−, O2+, and NO+ are seen with the mass spectrometer at the onset of irradiation. As the electron bombardment continues, these ions interact with beam-generated neutral species to produce a spectrum eventually dominated by NO+, NO2−, and NO3−. From measurements of O2+ production and loss rates as a function of irradiation time, the dominant NO production mechanism is shown to be O2+ + N2 → NO+ + NO with a rate constant ≤1×10−16 cm3/sec, followed by ionic recombination to neutralize the NO+. We measure the following thermal-energy two-body ionic recombination coefficients, in units of 10−8 cm3/sec: α(NO+, NO−3) = (3.4±1.2); α(NO+, NO−2) = (17.5±6.0); and α(O2+, O2−) ≤ (14±5). With water added to the gas, the sequence H3O+(H2O)n (n = 0, 1, 2, 3) becomes important in the positive-ion spectrum.
- Published
- 1972
16. AN EXPERIMENTAL INVESTIGATION OF THE EFFECTS OF RADIATION ON THE PROPAGATION OF ELECTROMAGNETIC SIGNALS IN AIR
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P. N. Eisner, J. W. Blaker, and M. N. Hirsh
- Published
- 1962
17. AN EXPERIMENTAL INVESTIGATION OF THE EFFECTS OF RADIATION ON THE PROPAGATION OF ELECTROMAGNETIC SIGNALS IN AIR
- Author
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M. N. Hirsh and P. N. Eisner
- Subjects
Spectrum analyzer ,Work (thermodynamics) ,Wave propagation ,Chemistry ,law ,Ionization ,Optical instrument ,Transient (oscillation) ,Mechanics ,Atomic physics ,Diffusion (business) ,Radiation ,law.invention - Abstract
The present report covers work performed during the period 1 January to 31 March 1963. It begins with a description of modifications made to the experimental equipment to permit the measurement of time-dependent ionization phenomena. The results of transient measurements in oxygen and N sub 2 - O sub 2 mixtures using these techniques is then presented. A detailed calculation of the role of diffusion in transient ionization phenomena has been started and is discussed in the report. The report closes with a description of the proposed work for the next quarter.
- Published
- 1963
18. Bedeutung und Anwendung der Exergie in der Wärmetechnik
- Author
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N. Eisner
- Published
- 1960
19. The ABCISIC ACID INSENSITIVE (ABI) 4 Transcription Factor Is Stabilized by Stress, ABA and Phosphorylation.
- Author
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Maymon T, Eisner N, and Bar-Zvi D
- Abstract
The Arabidopsis transcription factor ABSCISIC ACID INSENSITIVE 4 (ABI4) is a key player in the plant hormone abscisic acid (ABA) signaling pathway and is involved in plant response to abiotic stress and development. Expression of the ABI4 gene is tightly regulated, with low basal expression. Maximal transcript levels occur during the seed maturation and early seed germination stages. Moreover, ABI4 is an unstable, lowly expressed protein. Here, we studied factors affecting the stability of the ABI4 protein using transgenic Arabidopsis plants expressing 35S::HA-FLAG-ABI4-eGFP . Despite the expression of eGFP-tagged ABI4 being driven by the highly active 35S CaMV promoter, low steady-state levels of ABI4 were detected in the roots of seedlings grown under optimal conditions. These levels were markedly enhanced upon exposure of the seedlings to abiotic stress and ABA. ABI4 is degraded rapidly by the 26S proteasome, and we report on the role of phosphorylation of ABI4-serine 114 in regulating ABI4 stability. Our results indicate that ABI4 is tightly regulated both post-transcriptionally and post-translationally. Moreover, abiotic factors and plant hormones have similar effects on ABI4 transcripts and ABI4 protein levels. This double-check mechanism for controlling ABI4 reflects its central role in plant development and cellular metabolism.
- Published
- 2022
- Full Text
- View/download PDF
20. Nanocomposite coatings for the prevention of surface contamination by coronavirus.
- Author
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Toledo E, Dim S, Edri A, Greenshpan Y, Ottolenghi A, Eisner N, Tzadka S, Pandey A, Ben Nun H, Le Saux G, Porgador A, and Schvartzman M
- Subjects
- Antiviral Agents, Copper pharmacology, Humans, Pandemics prevention & control, SARS-CoV-2, COVID-19 prevention & control, Coronavirus OC43, Human, Nanocomposites
- Abstract
The current Covid-19 pandemic has a profound impact on all aspects of our lives. Aside from contagion by aerosols, the presence of the SARS-CoV-2 is ubiquitous on surfaces that millions of people handle daily. Therefore, controlling this pandemic involves the reduction of potential infections via contaminated surfaces. We developed antiviral surfaces by preparing suspensions of copper and cupric oxide nanoparticles in two different polymer matrices, poly(methyl methacrylate) and polyepoxide. For total copper contents as low as 5%, the composite material showed remarkable antiviral properties against the HCoV-OC43 human coronavirus and against a model lentivirus and proved well-resistant to accelerated aging conditions. Importantly, we showed that the Cu/CuO mixture showed optimal performances. This product can be implemented to produce a simple and inexpensive coating with long-term antiviral properties and will open the way to developing surface coatings against a broad spectrum of pathogens including SARS-CoV-2., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2022
- Full Text
- View/download PDF
21. Phosphorylation of Serine 114 of the transcription factor ABSCISIC ACID INSENSITIVE 4 is essential for activity.
- Author
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Eisner N, Maymon T, Sanchez EC, Bar-Zvi D, Brodsky S, Finkelstein R, and Bar-Zvi D
- Subjects
- Gene Expression Regulation, Plant, Genes, Plant, Genetic Variation, Genotype, Mitogen-Activated Protein Kinase Kinases genetics, Mitogen-Activated Protein Kinase Kinases metabolism, Mutation, Phosphorylation genetics, Phosphorylation physiology, Plant Growth Regulators genetics, Transcription Factors genetics, Abscisic Acid metabolism, Arabidopsis genetics, Arabidopsis metabolism, Plant Growth Regulators metabolism, Serine genetics, Serine metabolism, Transcription Factors metabolism
- Abstract
The transcription factor ABA-INSENSITIVE(ABI)4 has diverse roles in regulating plant growth, including inhibiting germination and reserve mobilization in response to ABA and high salinity, inhibiting seedling growth in response to high sugars, inhibiting lateral root growth, and repressing light-induced gene expression. ABI4 activity is regulated at multiple levels, including gene expression, protein stability, and activation by phosphorylation. Although ABI4 can be phosphorylated at multiple residues by MAPKs, we found that S114 is the preferred site of MPK3. To examine the possible biological role of S114 phosphorylation, we transformed abi4-1 mutant plants with ABI4pro::ABI4 constructs encoding wild type (114S), phosphorylation-null (S114A) or phosphomimetic (S114E) forms of ABI4. Phosphorylation of S114 is necessary for the response to ABA, glucose, salt stress, and lateral root development, where the abi4 phenotype could be complemented by expressing ABI4 (114S) or ABI4 (S114E) but not ABI4 (S114A). Comparison of root transcriptomes in ABA-treated roots of abi4-1 mutant plants transformed with constructs encoding the different phosphorylation-forms of S114 of ABI4 revealed that 85 % of the ABI4-regulated genes whose expression pattern could be restored by expressing ABI4 (114S) are down-regulated by ABI4. Phosphorylation of S114 was required for regulation of 35 % of repressed genes, but only 17 % of induced genes. The genes whose repression requires the phosphorylation of S114 are mainly involved in embryo and seedling development, growth and differentiation, and regulation of gene expression., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
22. Proteomic analyses of corneal tissue subjected to alkali exposure.
- Author
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Parikh T, Eisner N, Venugopalan P, Yang Q, Lam BL, and Bhattacharya SK
- Subjects
- Ammonium Hydroxide, Animals, Blotting, Western, Cattle, Cornea metabolism, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Eye Enucleation, Fluorescein metabolism, Fluorophotometry, In Situ Nick-End Labeling, Mass Spectrometry, Proteomics, Swine, Calcium Hydroxide toxicity, Cornea drug effects, Eye Proteins metabolism, Hydroxides toxicity, Sodium Hydroxide toxicity
- Abstract
Purpose: To determine whether exposure to alkaline chemicals results in predictable changes in corneal protein profile. To determine whether protein profile changes are indicative of severity and duration of alkali exposure., Methods: Enucleated bovine and porcine (n = 59 each) eyes were used for exposure to sodium, ammonium, and calcium hydroxide, respectively. Eyes were subjected to fluorescein staining, 5-bromo-2'-deoxy-uridine (BrdU) labeling. Excised cornea was subjected to protein extraction, spectrophotometric determination of protein amount, dynamic light scattering and SDS-PAGE profiling, mass spectrometric protein identification, and iTRAQ-labeled quantification. Select identified proteins were subjected to Western blot and immunohistochemical analyses., Results: Alkali exposure resulted in lower protein extractability from corneal tissue. Elevated aggregate formation was found with strong alkali exposure (sodium hydroxide>ammonium, calcium hydroxide), even with a short duration of exposure compared with controls. The protein yield after exposure varied as a function of postexposure time. Protein profiles changed because of alkali exposure. Concentration and strength of the alkali affected the profile change significantly. Mass spectrometry identified 15 proteins from different bands with relative quantification. Plexin D1 was identified for the first time in the cornea at a protein level that was further confirmed by Western blot and immunohistochemical analyses., Conclusions: Exposure to alkaline chemicals results in predictable and reproducible changes in corneal protein profile. Stronger alkali, longer durations, or both, of exposure resulted in lower yields and significant protein profile changes compared with controls.
- Published
- 2011
- Full Text
- View/download PDF
23. Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide.
- Author
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Ozer J, Eisner N, Ostrozhenkova E, Bacher A, Eisenreich W, Benharroch D, Golan-Goldhirsh A, and Gopas J
- Subjects
- Alkaloids administration & dosage, Alkaloids isolation & purification, Apoptosis drug effects, Breast Neoplasms drug therapy, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Line, Tumor, Cisplatin administration & dosage, Drug Synergism, Etoposide administration & dosage, Hodgkin Disease drug therapy, Hodgkin Disease metabolism, Hodgkin Disease pathology, Humans, Magnetic Resonance Spectroscopy, Methanol chemistry, NF-kappa B metabolism, Plant Extracts administration & dosage, Plant Extracts isolation & purification, Sulfhydryl Compounds isolation & purification, Sulfhydryl Compounds pharmacology, Alkaloids pharmacology, Antineoplastic Combined Chemotherapy Protocols pharmacology, Cisplatin pharmacology, Etoposide pharmacology, NF-kappa B antagonists & inhibitors, Nuphar chemistry, Plant Extracts chemistry, Plant Extracts pharmacology
- Abstract
We screened thirty-four methanolic plant extracts for inhibition of the constitutive nuclear factor kappaB (NFkappaB) activity by a NFkappaB-luciferase reporter gene assay. Strong inhibition of NFkappaB activity was found in extracts of leaf and rhizome from Nuphar lutea L. SM. (Nuphar). The inhibitory action was narrowed down to a mixture of thionupharidines and/or thionuphlutidines that were identified in chromatography fractions by one- and two-dimensional NMR analysis. Dimeric sesquiterpene thioalkaloids were identified as the major components of the mixture. The Nuphar alkaloids mixture (NUP) showed a dose dependent inhibition of NFkappaB activity in a luciferase reporter gene assay as well as reduction of nuclear NFkappaB subunits expression as tested by western blots and immunohistochemistry. Decreased DNA binding was demonstrated in electro mobility shift assays. NUP inhibited both inducible and constitutive NFkappaB activation and affected the canonical and alternative pathways. Suppression of NFkappaB was not cell type specific. Induction of apoptosis by the alkaloid mixture was demonstrated by time-dependent and dose-dependent cleavage of procaspase-9 and PARP. Synergistic cytotoxicity of the active mixture with cisplatin and etoposide was demonstrated. Overall, our results show that NUP inhibits the NFkappaB pathway and acts as a sensitizer to conventional chemotherapy, enabling the search for its specific target and application against cancer and inflammation.
- Published
- 2009
- Full Text
- View/download PDF
24. Psychiatric and pain characteristics of prescription drug abusers entering drug rehabilitation.
- Author
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Passik SD, Hays L, Eisner N, and Kirsh KL
- Subjects
- Adult, Alcohol Drinking, Chronic Disease, Cross-Sectional Studies, Female, Humans, Kentucky, Male, Opioid-Related Disorders etiology, Pain complications, Prospective Studies, Smoking, Drug Prescriptions, Opioid-Related Disorders psychology, Pain drug therapy, Stress, Psychological psychology, Substance Abuse Treatment Centers
- Abstract
There has been intense interest in the problem of prescription drug abuse on the parts of health professionals, law enforcement, the media, and the general public. Clinicians not only need to know how to assess risk but also what drugs are being diverted most in their region. We conducted a prospective survey of prescription drug abusers entering a treatment facility in central Kentucky. Participants (n = 109) were enrolled and completed a structured clinical interview and prescription drug abuse survey. The prescription drug abusers assessed in the study had a mean age of 30.95 years (SD = 10.21), were comprised of 75 men (69%) and 34 women (31%), and were mostly Caucasian (98%). The majority (84%) stated that they had legitimately been given a prescription for opioids for pain at some point from a physician and 61% reported chronic pain concerns. The most commonly abused drugs were hydrocodone-containing formulations (78%) and oxycodone-containing products (69%), while products containing methadone (23%) or fentanyl (7%) were abused much less frequently. Most respondents (91%) stated that they had purchased prescription opioids from a street dealer at least once and the majority (80%) had altered the delivery system of the prescription drug by chewing, snorting, or using i.v. administration. Implications for pain management are discussed, focusing on the need for clinicians treating chronic pain to more thoroughly assess patients for their risk of abuse and addiction before starting an opioid regimen.
- Published
- 2006
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