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Aim. To study the role of mononucleotide polymorphisms of the matrix metalloproteases genes MMP2 and MMP9 in the development of ascending aorta aneurism (AOA).Material and methods. Totally 287 patients included with AOA and 227 persons of control group. All patients underwent echocardiography and assessment of mononucleotide gene polymorphisms of MMP2 (rs2285053) and MMP9 (rs11697325, rs2274755, rs17577) real-time, by PCR.Results. The association of MMP9 (rs11697325) is confirmed for the formation of AOA. AA genotype was significantly more prevalent among AOA patients (c2 =7,2; p=0,01). AA genotype carriers had higher ascending aorta diameter comparing to other persons with different variants (p=0,02). The relation is shown of the polymorphism ММР2 (rs2285053) and AOA development. Persons with CC genotype were more prevalent in the group of the aorta pathology patients (c2 =7,0; р=0,03).Conclusion. Genetic variants ММР9 and ММР2 can be additional risk factors of ascending aorta aneurism development. Therefore the assessment of different polymorphisms of matrix metalloproteases genes is useful for the risk stratification of the patients with ascending aorta dilation.

Aim. To evaluate the significance of osteopontine and MMP-9 in the development of thoracal aorta aneurysm in patients with tricuspid (TAV) and bicuspid (BAV) aorta valve. Material and methods. Totally 94 patients included with the dilation of thoracal aorta for more than 40 mm, and 50 patients without aorta pathology, that were the comparison group. All patients underwent echocardiographic study by Vivid 7 (GE, USA) device by standard protocol. The osteopontine concentration and MMP-9 were measured in blood serum with manual plate immune-enzyme assay. Results. The concentration of MMP-9 in blood serum of the patients with aorta pathology and TAV did not differ significantly with the value in comparison group. Otherwise, in IHD the concentration of MMP-9 was significantly higher than in patients without aorta pathology (164,9±76,6 ng/ml and 106,8±82,7 ng/ml, respectively, p

Aim. To assess the impact of disturbed extracellural matrix protein balance and matrix metalloproteinase (MMP) activity on the development of ascending aortic aneurysm (AAA) of varied aetiology. Material and methods. The study included 38 patients with AAA and 17 controls without any aortic pathology. In intra-surgery biopsy samples, the levels and activity of MMP-2, MMP-9, fibrillin, elastin, and collagen were measured. Results. Elevated levels of latent MMP-9 and MMP-2 forms were observed in patients with atherosclerosis and tricuspid aortic valve, compared to controls. In participants with bicuspid aortic valve, the levels of both latent and active MMP-9 forms were higher than in controls. In biopsy samples, the elastin-to-collagen ratio values were elevated in patients with atherosclerosis (1:1,7) and bicuspid aortic valve (1:1,6). Conclusion. The difference in the MMP levels and activity and the increased collagen-to-elastin ratio could be related to the underlying mechanisms of the AAA development in patients with bi- and tricuspid aortic valve.