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The trend of growing interest in project management as a tool to improve the competitiveness of organisations refers in full extent to Higher Education Institutions (HEIs), which due to their educational function should ensure the advanced implementation of project management in the management processes of their own activities. The state policy in the field of project management promotion defines new challenges for effective management and for the education sector. The large-scale modernization of public administration of the Republic of Kazakhstan based on project management, in turn, poses the task of modernizing the management systems of HEIs. In addition, the changed conditions of the geopolitical situation dictate the necessity of applying modern management technologies. The purpose of the research is to study the peculiarities of project management development in HEIs in Kazakhstan. General scientific methods – analysis, synthesis, generalization are used as research methods. The results of the study contribute to the study of aspects of project management implementation and the development of technology of project management implementation in HEIs. For a comprehensive study of the subject of research, it is important to systematize the elements affecting the functioning of HEIs in Kazakhstan, in two planes: internal and external. In order to solve this issue, the external and internal factors of project management development in HEIs of Kazakhstan are formulated, the generalization of experience on interaction with HEIs of Union of Project Managers of the Republic of Kazakhstan is presented, the experience of Kazakh National Agrarian Research University is highlighted. The tasks for HEIs, the main directions of interaction between the universities and the professional project community are determined. The identification of external and internal factors affecting the activities of HEIs in Kazakhstan will allow adjusting the objectives of the university development.

Lactic acid is used in various industries: chemical, food, cosmetic, pharmaceutical, agriculture and polymer production. 40% of the domestic market demand for lactic acid is met through imports, while the main methods for producing lactic acid are microbiological or synthetic. The most rational is microbiological synthesis, however, when it is implemented, valuable sugar-containing substrates (crystalline sucrose, molasses, sugar syrup) are used, which significantly affects the cost of the final product. There was an obvious need to search for new technologies for the production of lactic acid. Prospective and cost-effective is the processing of whey into lactic acid using bacterial fermentation of the lactose contained in the whey. The aim of the study is to screen cultures of microorganisms capable of fermenting lactose contained in milk whey and to select the composition of the medium that provides the maximum yield of lactic acid. Strains of lactic acid bacteria were used in the experiment: Leuconostocmesenteroides subsp. mesenteroides 122 (B1699), Lactobacillus brevis B78 (B5728), Lactobacillus plantarum K9 (B5466), Lactobacillus casei C1 (B5726), Lactobacillus acidophilus (B9012), Lactobacillus paracasei BT 24/88 (B6253), Lactobacillus paracasei 139 (B2430), obtained from the Russian National Collection of Industrial Microorganisms (Scientific Center "Kurchatov Institute" -Research Institute for Genetics and Selection of Industrial Microorganisms). The authors determined the optimal composition of the medium for the biosynthesis of lactic acid by selecting the concentrations of yeast autolysate and salt solution that provide the maximum yield of lactic acid. The authors also selected the optimal duration of lactic acid biosynthesis. The study of the acid-forming ability of strains of lactic acid bacteria showed that of the strains studied, Lactobacillus casei C1 (B5726) showed the greatest ability to ferment lactose by synthesizing lactic acid, which correlates with the data on assimilation of lactose by the culture. The optimal cultivation time (132 h) and the concentration of yeast lysate (5%) in a nutrient medium based on curd whey were selected. With optimal parameters, the maximum concentration of lactic acid in the culture liquid of Lactobacillus casei C1 (B5726) was 54.77 g / L, which is comparable with the currently used producers in the industrial production of lactic acid.

Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine and enthesis from the group of spondyloarthritis that develops in patients with psoriasis. Guselkumab is a biologic disease-modifying antirheumatic drug, an inhibitor of interleukin 23, which has been shown to be effective in the treatment of plaque psoriasis and PsA.Objective: to evaluate the effectiveness of guselkumab treatment in PsA patients.Patients and methods. The study included 16 patients with PsA. All patients received 100 mg of guselkumab subcutaneously at weeks 0, 4, 12, 20. Disease activity and treatment efficacy were assessed at weeks 0, 12 and 24 using the DAS28, ASDAS, BASDAI, DAPSA activity indices, the index of the extent and severity of psoriasis PASI.Results and discussion. During treatment, patients with PsA showed a pronounced positive dynamics of the indices of disease activity and an improvement in the skin condition. Before the treatment with guselkumab, the mean value of the DAS28 index was 4.26±0.64, DAPSA – 37.94±9.45, ASDAS – 2.7±0.65, and BASDAI – 5.49±1.39, after 12 weeks of treatment these indicators decreased to 3.03±0.49; 17.06±4.58; 1.64±0.33 and 3.48±0.66, respectively, and after 24 weeks (after the 4th injection) – to 2.32±0.18; 11.31±2.18; 1.22±0.27 and 2.62±0.78, respectively (pThe treatment was well tolerated during the 24 weeks of the study, and no serious adverse events were reported.Conclusion. The data from real clinical practice indicate that guselkumab is highly effective and safe in the treatment of PsA.

The purpose of the study is to highlight the clinical experience of specialists from various countries, clinics and neurological specialties, in order to form an up-to-date review of the speech function neurophysiology, as well as the features of pathology, diagnosis and treatment of aphasia, as one of the most disabling symptoms accompanying ischemic stroke. Results. The speech function does not only limit communication options between doctor and patient, but it is also an important factor that makes it difficult to collect anamnesis and interpret the results of a neurological examination. In addition, the quality of life of patients with speech disorders is significantly reduced, they experience remarkable difficulties in interacting with society, and they stop building new communication connections. Taking into account the intensive use of modern neuroimaging methods in scientific studies, a large amount of new data has appeared about the brain functioning in normal and pathological conditions. Due to significant disadvantages, the classical model of the functioning of such a cognitive domain as speech has not just undergone significant changes, but has been almost completely revised. Now, it is not limited only by the two key regions – Broca and Wernicke, and also does not ignore the existence of subcortical structures and connections. The whole set of structures that provide the speech functioning is combined into the concept of "speech connectome". It includes four main groups of associative connections: frontotemporal, occipito-parietal, occipito-temporal and fronto-frontal. The lesion of each of the groups is manifested by certain symptoms, which are combined into several typical clinical patterns. This approach allows clinicians to take a fresh look at the diagnosis of speech disorders, as well as significantly expand therapeutic opportunities in this area. Usage of diagnostic scales and tests, neuroimaging methods, as well as biomarkers of cognitive-aphasic decline is now focused not only on finding the affected structures of the cerebral cortex, but also at interpreting the clinical picture in the form of so-called disconnection syndromes, which is the result of lesions of the neural pathways in the white matter. Conclusion. Speech-language therapy remains the gold standard and an integral part of the treatment of aphasia, and the use of drugs is mainly focused on modulating the work of various neurotransmitter systems. But therapeutic and rehabilitation options based on modern neuroimaging data (in particular, using diffusion-weighted magnetic resonance imaging) can significantly improve the effectiveness of treatment and functional recovery. However, this area remains very promising for further study and more extensive scientific research

The sorption parameters of a sorbent based on tetraoctyldiglycolamide (TODGA) and hypercrosslinked polystyrene AXIONIT MND 50 produced by the Russian company Axion-RDM relative to REE ions were studied. It is shown that the sorption parameters of the sorbent relative to REE (neodymium) in nitric acid media rise with an increase in the acidity and temperature of the solution and with a decrease in the filtration rate. Complete desorption of REEs occurs when 15 column volumes (c.v.) of a 0.01 M HNO3 solution are passed through, which allows using the AXIONIT MND 50 sorbent in a multicyclic sorption–desorption mode. In the sorption of REE (152Eu) from solutions prepared by dissolving sulfonic cation resin in nitric acid solutions in the presence of hydrogen peroxide and ferric ions, almost complete extraction of 152Eu is achieved at passing 550 c.v. solution. During the second sorption cycle, the volume of the purified solution is reduced by almost 10 times, which excludes the feasibility of its repeated use. A method is proposed for the disposal of spent ion resins containing residual amounts of REE and TPE radionuclides by their complete chemical dissolution with subsequent sorption extraction of radionuclides from the resulting solution using a TODGA-based sorbent AXIONIT MND 50.

The behavior of uranium and thorium ions in nanofiltration (NF) from aqueous solutions has been studied. It was shown that the retention capacity (R) of the NF membrane for uranium and thorium depends on their state in aqueous solutions. In the case of uranium, the smallest values of R (82–83%) are observed when uranium is in solution as uranyl ions or oxyhydrate complexes at pH in the range from 2 to 6. In solutions with large pH values, the retention of uranium increases (R ≈ 95%) due to the formation of an insoluble U(IV) hydroxide and/or carbonate complexes. In the NF of aqueous solutions of thorium, R grows from 94 to 99% with pH increasing from 1 to 3.5, which is due to the hydrolysis of thorium ions to give oxyhydrate complexes of various compositions. At pH 3–9, the retention of thorium remains constant due to the formation of an insoluble thorium hydroxide. In alkaline solutions (pH > 9), values of R decrease because of the formation of negatively charged hydroxo and/or carbonate complexes. A conclusion is made that the nanofiltration is an effective method for wastewater purification to remove admixtures of uranium and thorium.

The internal friction spectra λ = f(T) and the temperature dependence ν = f(T) of the frequency of free damping in the temperature range from –150°C to 120°C of microwave-irradiated and nonirradiated samples of polyvinyl alcohol were obtained. A theoretical analysis of nature of the peak located on the ascending branch of the α-peak of relaxation losses on the internal friction spectrum is carried out, and its disappearance after the microwave irradiation is explained. A comparison of changes in the continuous spectrum of relaxation times in the region of glass-transition temperature is performed. It is established that microwave irradiation expands the spectrum of relaxation time, and, consequently, increases the relaxation microinhomogeneity of the α-relaxation process.

In this work, the chemical digestion conditions for spent KU-2 × 8 sulfocationites manufactured in Russia were investigated. It was shown that the complete oxidative digestion of the ionites could be performed in solutions of H2O2 and HNO3 in the presence of Fe3+ ions adsorbed on the resin as an oxidation catalyst. The total digestion time of the resin was studied as a function of the presence of the digestion catalysts, solid-to-liquid phase ratio, process temperature, Fe3+ ion content in the solid sulfocationite phase, and the divinylbenzene (DVB) cross-linking agent content of the ionite. A possibility for the removal of rare earth element (REE) and transplutonium element (TPE) radionuclides from the solution of the digested sulfocationite was shown by the sorption technique using the tetra-n-octyldiglycolamide (TODGA)-based sorbent.

Intermediate ultraviolet (UVB) therapy is considered a relatively safe method of treating skin diseases with an autoimmune component in development compared to medical drug methods, including PUVA therapy. This is due to the small depth of penetration of the rays of this wavelength range into skin, which provides a purely local effect on the human body. Excimer lamps are an alternative to the expensive excimer laser for phototherapy of psoriasis or vitiligo. However, for effective phototherapy using UVB lamps, the distance from an emitter to a patient’s skin must be considered. In this paper, we report on treatment of patients using an excimer lamp, the control unit of which is equipped with an optical system for controlling of ultraviolet radiation dose, which allows automatically calculating the time for a set UVB dose. The article describes the results of phototherapy using an excimer lamp of several cases of psoriasis, vitiligo and other forms of dermatitis with a good therapeutic and cosmetic effect. When using an excimer lamp, not a single case of exacerbation of dermatological diseases was established.

Sorption of a series of alkaline earth and nonferrous metals (Ca, Mg, Cu, Ni, and Zn) from lithium hydrocarbonate and chloride solutions onto ion-exchange resins of various classes was studied. The highest values of the static exchange capacity were observed in sorption from a LiHCO3 solution onto imino carboxylic ion exchangers Amberlite IRC 748 (Rohm and Haas, the United States), Purolite S930 (Purolite, the United Kingdom), and AXIONIT 3S (AO Aksion RDM, Russia). In sorption from a LiCl solution with рН 1.4, the sorption capacity of all the sorbents tested is 3–7 lower. Sorption treatment of a LiHCO3 solution to remove Na, K, Са, Mg, Al, Si, Ti, Cr, Mn, Fe, Ni, Cu, and Zn impurities under dynamic conditions using AXIONIT 3S imino carboxylic sorbent was performed. The sorption ensures deep removal of Ca, Cu, and Zn impurities from a LiHCO3 solution. A procedure was suggested for preparing high-purity lithium carbonate by ion-exchange purification of a LiHCO3 solution on an imino carboxylic sorbent, followed by thermal decomposition of the purified solution at the boiling point to obtain a lithium carbonate precipitate. Lithium carbonate with the main substance content of 99.90 ± 0.05 wt % was obtained.

Possibility of performing deep purification of lithium hydroxide solutions to remove admixtures of alkaline-earth and transition metals, magnesium, aluminum, uranium, thorium, and radium radionuclides (strontium) by using the sorption and membrane methods has been examined. It was shown that successive procedures of mechanical filtration, ultrafiltration with a ceramic membrane having pore size of 50 nm, and sorption purification on an imine carboxyl cation exchanger make it possible to obtain lithium carbonate with no less than 99.9% main substance. The content of impurities being determined in the sample obtained does not exceed 0.005–0.01 wt %. The specific activity of a sample as regards the sum of alpha- and beta-emitters does not exceed their lower detection limit (less than 0.1 Bq/g).

Relevance . The article is devoted to a topical problem - treatment and prevention of atopic dermatitis in children, which occurs most often in the practice of pediatricians and dermatologists, taking leading positions among the diseases of childhood. The prevalence of atopic dermatitis among children’s population is about 20%. To treat atopic dermatitis, along with diet and drug therapy, the possibility of using probiotics is being discussed. Literary analysis and practical experience show the significant role of probiotics in the prevention and treatment of atopic dermatitis patients. Due to the unfavourable environmental situation, changing nutrition patterns and increasing percentage of children on complementary feeding, there is a steady increase in allergic diseases in children worldwide. Aim. The aim of the study was to justify the efficacy and safety of probiotics for the recovery of intestinal microbiocenosis in integrated therapy and prevention of atopic dermatitis in children. Materials and methods . As materials of the study the review of the literature sources and clinical cases of complex treatment of atopic dermatitis with addition of probiotics Linex baby® to the basic therapy are presented. Clinical manifestations of the disease were assessed. Addition of probiotic Linex baby® contributed to a marked decrease in the typical clinical manifestations of the disease, the intensity of itching, and the resolution of rashes in a shorter period of time compared to patients in whom no probiotics were used. Conclusions. Thus, the addition of probiotic Linex baby® to the basic therapy of atopic dermatitis contributed to a shortening of the period of exacerbation of the disease and marked improvement of the clinical picture of the disease, which confirms the prospects and feasibility of probiotic drugs in the treatment of this disease.

Mineral composition, physicochemical properties and sorption characteristics of clay-salt slimes (CSS), wastes formed in processing of the sylvinite ore at JSC “Belaruskali” (Soligorsk, Belarus) and aluminosilicate and illite sorbents produced on their basis were studied. It was shown that dressing of CSS samples results in that their chemical and mineralogical compositions change. It was found that the washing of CSS with water, followed by treatment with hydrochloric acid and Trilon B, leads to a 1.2–1.3 times increase in the content of the main component of CSS, illite, due to the dissolution of carbonates (dolomite and calcite) and gypsum. It was found that presence of illite plays a key role in the sorption activity of the sorbents toward the radionuclides 137Cs and 90Sr. With enriched samples of illite sorbents (IS-3o and IS-3m),the distribution coefficients of 137Cs become twice larger, and those of 90Sr, 20 times larger in comparison with the undressed samples of aluminosilicate sorbents (AS-3o and AS-3m). It is shown that the production of aluminosilicate and illite sorbents from CSS and the use of these sorbents for purification of liquid radioactive wastes to remove the radionuclides 137Cs and 90Sr and for creating barriers providing the safe storage and burial of low- and medium-activity of radioactive wastes are promising.

A review is presented of the work performed from the early 1950s to the present at the Laboratory of Radioelement Chromatography of the USSR Academy of Sciences’ Institute of Physical Chemistry (the Russian Academy of Sciences’ Frumkin Institute of Physical Chemistry and Electrochemistry). The works in the field of studying the patterns of sorption and dynamics of chromatography for systems of chelate displacement chromatography (CDC), the chromatographic separation of elements under conditions of ionizing radiation, and the chromatographic separation of radionuclides with the use of separating ions are described. The separation of 137Cs radionuclide from irradiated nuclear fuel (INF) reprocessing solutions using ferrocyanide sorbents, the use of ion-exchange resins for the recovery of rare-earth elements (REEs) and actinides from solutions of different composition, and advances in the field of the sorption purification of liquid radioactive wastes of different chemical and radionuclide composition are also considered. The means developed at the Laboratory provided the basis for the technologies of the separation of radioactive elements from INF reprocessing solutions and the purification of liquid radioactive wastes. These technologies are used today at enterprises of the Rosatom State Atomic Energy Corporation, nuclear power stations, and other facilities of the nuclear industry.

Extraction from aqueous solutions of oxalate and ethylenediaminetetraacetate (EDTA) ions, anionic (ASF) and nonionogenic (NSF) surfactants, and a complex of Co(III) with EDTA by the nanofiltration (NF) method was studied. It was shown that 98–99% of NSFs and EDTA, 85–90% of ASFs and oxalate ions, and 76–79% of the Co(III)–EDTA complex can be extracted with the use of a polymeric NF membrane. The possibility is demonstrated of effectively extracting EDTA and oxalate ions with an NF membrane at solution pH varied within the range 1–13 and sodium nitrate concentrations of 0 to 159 g/dm3. A conclusion is made that using the nanofiltration method is promising for effective removal of various organic complexing and surface-active substances and the Co(III)–EDTA complex from solutions with complex salt composition.

The paper describes the main types of sorption materials used to remove cesium and strontium radionuclides from low-level and intermediate-level liquid radioactive waste (LRW). It mainly focuses on sorbents produced at an industrial or pilot scale in Russia. Based on a developed standardized technique, it presents the experimental values for 137Cs and 90Sr distribution coefficients (Kd ) accounting for various types of sorbents. The study demonstrates that based on the developed technique, sorption characteristics of various types of sorption materials can be compared in an unbiased manner and most effective sorbents can be reasonably selected to treat liquid radioactive waste of various salt and radionuclide composition.

Sorbents based on manganese oxides were prepared by KMnO4 reduction in aqueous-ethanol medium. The influence of the synthesis conditions (temperature and time of the sol-gel synthesis, type of structure-forming cations, calcination temperature) on the pore structure and on the performance and selectivity in 90Sr sorption was studied. The sorbents have the mesoporous structure with the specific surface area of 180–220 m2 g−1 and mean pore size of 10–20 nm. Manganese oxide of channel structure in the Na+ form, prepared by the reaction at 25°C for 5 h and heat-treated at 350°C, exhibits the highest performance and selectivity in 90Sr sorption (distribution coefficient Kd = 1.04 × 104 cm3 g−1, Sr-Ca separation factor DSr/Ca = 99). The sorbents synthesized exhibit the highest performance and selectivity in neutral and alkaline media.

Sorption of Sr(II) and Pb(II) onto impregnated sorbents based on di(tert-butylcyclohexano)-18-crown-6 and an ionic liquid, 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (C4mim+Tf2N−), was studied. The influence of the crown ether concentration in the sorbent, kind and pretreatment of the support, and kind of the solvent used for impregnation on the sorption of Sr and Pb onto sorbents based on di(tert-butylcyclohexano)-18-crown-6 and C4mim+Tf2N− was analyzed. Sr(II) is taken up most efficiently from neutral and weakyl acidic (up to 0.01 M HNO3) media with the degree of sorption R > 90% and distribution coefficients Kd from 1410 to 706 cm3 g−1, respectively. The efficiency of the Sr(II) sorption is not affected by Na+ ions in the solution up to their concentration of 1 M. In the presence of calcium ions, as the Ca(II) concentration in the solution is increased from 0.02 to 0.16 M, Kd of Sr(II) decreases by a factor of 4. In sorption of 90Sr from seawater, Kd is 193 cm3 g−1; it increases by a factor of 1.05 and 1.25 upon dilution of seawater by a factor of 2 and 10, respectively. Lead(II) is quantitatively taken up from neutral media (R > 98%) and from 0.01–1.0 M HCl and 0.01–3.0 M HNO3 solutions (R > 87%). The sorbents prepared show promise for radioanalytical determination of Sr and Pb radionuclides in natural objects.

40Ar/39Ar datings of quartz-mica-sulfide, quartz-gold-arsenopyrite-pyrrhotite and quartz-gold-antimony associations at the ultra-large (more than 1000t. Au) Olimpiadinski gold deposit (Yenisei ridge) have been correlated. It was found that hydrothermal activity at the deposit lasted at least 150 ma.y. from 817 to 660 ma.y.

In this study, nanostructured manganese oxides were synthesized using sol–gel method by reduction of KMnO4 with ethyl alcohol. Firstly, the effect of K+, Na+, Ca2+, and Mg2+ ions as templates on their structure and adsorption properties was studied. According to X-ray diffraction analysis, all samples were identified as amorphous phases. Fourier-transform infrared spectroscopy confirmed that prepared sorption materials had a band around 760 cm−1, characteristic for the tunnel-type manganese oxides. The BET surface area of the obtained samples was 188–293 m2 g−1, the sorption volume of 0.431–1.136 m3 g−1, and the average pore size of 6–20 nm. The maximum Sr2+ sorption capacity of 120 mg g−1 was observed for the non-templated manganese oxide sorbents synthesized at 25 °C during 5 h. The calculated isotherm parameters and corresponding correlation coefficients revealed that the Sr2+ uptake process followed the Freundlich and Redlich-Peterson models for metal ion-templated manganese oxides. The increase in temperature and time of synthesis, as well as the application of K+, Na+, Ca2+, and Mg2+ ions as templates led to the decrease of sorption capacity down to 40–60 mg g−1 and 60–80 mg g−1, respectively. The highest sorption efficiency of metal ion-templated manganese oxides in Na+, K+, and Ca2+-form was shown for 90Sr, its Kd being (3.8–5.1) × 103 cm3 g−1. For Na+ ion-templated sample, as typical, the Kd values were 2.0 × 10−1–8.6 × 104 cm3 g−1 in the pH range of 0.5–12.0 and 3.5 × 102–6.2 × 101 cm3 g−1 for Ca2+ ion concentration varied from 10 to 80 mM, respectively.

Electromembrane processes have been used to reduce 100–1000 times the carryover of cadmium ions from cadmium electroplating baths into electroplating wastewater. Laboratory experiments and industrial practice have shown that the efficiency of the process depends on the type of cadmium plating electrolyte used: it is maximum for cyanide electrolytes (cadmium recovery efficiency is 99.9%) and minimum for sulfuric acid electrolytes free of ammonium ions (recovery efficiency is 99%). The technology and equipment developed are used in a number of industrial plants.

The behavior of salts (chlorides, nitrates, sulfates, phosphates, borates, ferri- and ferrocyanides) of various alkali metals (Li, Na, K, Cs) and ammonium in the course of nanofiltration (NF) of their aqueous solutions was studied. The NF polymer membrane at high salt concentrations (>30 g dm−3) retains alkali metal and ammonium ions to a low extent (1–5%). At lower salt concentrations, the retaining ability of the NF membrane increases. In nanofiltration of solutions of Na and K salts with anions of different charge, the retaining ability of the NF membrane increases with an increase in the anion charge. The pH dependence of the ability of the NF membrane to retain sodium nitrate was studied. This parameter was constant at pH in the ranges 2.0–5.5 and 7.5–13.0, but at pH in the range 5.5–7.5 the retaining ability decreased approximately by half. Experiments on retention of sodium borates of various compositions showed that the solutions containing bulky polynuclear anions consisting of 4–5 boron atoms were retained by the NF membrane with 45–50% efficiency, whereas neutral boric acid molecules were not noticeably retained by the membrane. Thus, nanofiltration can be used for selective separation of inactive alkali metal salts from radioactive components of liquid radioactive waste.

New cement compositions for solidifying mixtures of spent ion-exchange resins in sodium, nitrate, and tetraboric-acid form were developed. Depending on the composition of the cement and the ionic form of the anionite, the proposed cements make it possible to incorporate into the matrix 22–83 wt.% more ionexchange resins compared with using conventional portland cement. The matrices with heightened content of ion-exchange resins meet the requirements of cemented radioactive waste in terms of strength, water resistance, and leaching of 137Cs.

The retention of 16 quinoline and tetrahydroquinoline derivatives was investigated under liquid chromatography conditions using porous graphitized carbon (PGC), octadecyl silica (ODS) and hypercrosslinked polystyrene (HCLP) stationary phases. For most of the analytes, retention on PGC was greater than on ODS, while retention on HCLP was even greater than on both ODS and PGC. The non-linearity of retention dependencies on acetonitrile content in the eluent was observed for compounds containing carboxy, hydrazo and methoxy groups. The relationships between quinolines structure and their retention factors were investigated. It was found that sorption on different sorbents correlated with different descriptors. Retention on ODS was found to be highly correlated with lipophilicity only while on HCLP it depended on both lipophilicity and polarizability of the sorbates. The feature of PGC was a good correlation of retention factors with topological and geometrical parameters. Additionally, ability of PGC to form OH…π bonds with hydroxymethylquinolines was found. The observed regularities allow one to rationally optimize the chromatographic analysis of structurally similar compounds, which is very important for bioactive substances.

The structure of water–acetonitrile solutions of derivatives of quinoline and tetrahydroquinoline is investigated by means of аb initio molecular dynamics. It is shown that the propensity of molecules to form different types of hydrogen bonds depends largely on both the nature of the functional groups and on steric factors. When porous graphitic carbon is used as a sorbent, a linear correlation is observed between the fraction of configurations with hydrogen bonds and the logarithm of the retention factor under conditions of reverse-phase liquid chromatography.

As a result of the examination of 240 patients with verified diagnosis of spondylogenic vertebrobasilar insufficiency (sVBI), the usage of the screening algorithm was substantiated. This system provides decreasing of terms for diagnostics and volume of diagnostical procedures. The efficacy of screening algorithm on the base of examination of 136 healthy persons and 240 patients with sVBI (І stage — 104, ІІ stage — 76, ІІІ stage — 60 patients) was confirmed. On the base of the results of SVBI‑pro system, it has been revealed, that among 136 healthy people 7 people had the sVBI (the mistake of hyperdiagnostics is 5.1 %), among 240 patients with verified sVBI, 32 people were identified as a healthy persons by SVBI‑pro (the mistake of hypodiagnostics is 13.3 %). The data confirms the efficacy of the early diagnostic method and necessity of individual sVBI stage verification., По результатам обследования 240 больных с верифицированным диагнозом «спондилогенная вертебробазилярная недостаточность» (CВБН) была обоснована и разработана информационно‑консультативная система «SVBI‑pro», позволяющая сократить термины и объем обследований при одновременном повышении доступности диагностики CВБН. Эффективность использования информационно‑консультативной системы «SVBI‑pro» исследовали инверсным методом у 136 пациентов молодого возраста без неврологической патологии и 240 пациентов с верифицированным диагнозом CВБН (І стадия — 104, ІІ — 76, ІІІ — 60). Из 136 клинически здоровых по результатам алгоритмизированной оценки с помощью системы «SVBI‑pro» у 7 выявлено наличие CВБН (ошибка гипердиагностики — 5,1 %), а из 240 пациентов с верифицированной CВБН 32 пациента идентифицированы как здоровые (ошибка гиподиагностики — 13,3 %). Частота ошибок гиподиагностики зависела от стадии заболевания: при CВБН‑І — 21,1 %, при CВБН‑ІІ — 10,5 %, при CВБН‑ІІІ — 3,3 %, что определяет разную эффективность ранней диагностики и необходимость в персонализированном подходе к верификации стадии CВБН., За результатами обстеження 240 хворих з верифікованим діагнозом «спондилогенна вертебробазилярна недостатність» (CВБН) обґрунтовано та розроблено інформаційно‑консультативну систему «SVBI‑pro», яка дає змогу скоротити терміни діагностики та обсяг обстежень при одночасному підвищенні доступності діагностики CВБН особливо при скринінгових обстеженнях. Ефективність застосування інформаційно‑консультативної системи «SVBI‑pro» досліджували інверсним методом у 136 пацієнтах молодого віку без неврологічної патології та 240 хворих із верифікованим діагнозом CВБН (І стадія — 104, ІІ — 76, ІІІ — 60). Із 136 клінічно здорових за результатами алгоритмізованої оцінки за допомогою системи «SVBI‑pro» у 7 виявлено наявність CВБН (помилка гіпердіагностики — 5,1 %), а із 240 хворих із CВБН 32 ідентифіковано як здорові (помилка гіподіагностики — 13,3 %). Частота помилок гіподіагностики залежала від стадії захворювання: при CВБН‑І — 21,1 %, при CВБН‑ІІ — 10,5 %, при CВБН‑ІІІ — 3,3 %, що визначає різну ефективність ранньої діагностики та потребу в персоналізованому підході до верифікації стадії CВБН.

The relationship between the leveling power of electrolytes, the primary current distribution, and the microdistribution of the metal deposition rate is considered. For electrolytes with positive, zero, and negative leveling power, the calculations of microdistribution of metal deposition rate are carried out with regard to the data on the primary current distribution obtained experimentally for a macromodel of the microprofile under study. Good agreement is demonstrated between the microdistribution calculated using the described method and the results of direct measurements of metal distribution over the surface with the regular twodimensional microprofile.

The role of the macro- and microdistribution factors in the electrodeposition of metals and alloys on the components of electronic devices has been studied. There are three types of deviation of the deposition rate distribution from uniform distribution caused by differences: (1) in the surface area of ​​the cathode and dielectric sections, (2) in the deposition rate in the individual sections of one group, and (3) between the local deposition rates at different points of the surface of the individual cathode section. Methods for evaluating the microthrowing and leveling ability and predicting the microdistribution from the leveling ability data and the use of the Wagner number for evaluating the role of the macrodistribution factors were considered. Examples were given to illustrate the types of deposition rate distribution from electrolytes with positive, zero, and negative leveling ability.

The use of the electromembrane method for the purification of chromium plating electrolytes from cationic impurities (iron, copper, etc.) by three approaches are described. The first variant is based on the removal of these ions during their migration from the solution to be purified into a catholyte through a cationexchange membrane. The second variant is a transfer of chromate anions from a contaminated solution into the anolyte through an anion-exchange membrane. In the third method for the recuperation of chromic acid, accumulated in a recovery bath, it is proposed to use the immersed electrochemical module, combining the processes of concentration and purification from impurities, instead of evaporation.

A number of sorbents based on di-(tert-butylbenzo)-18-crown-6, 1-octanol, and various supports (LPS-500, hydrophobized silica) was obtained. The effect of temperature, support impregnation time, and thiocyanate ion concentration on cobalt sorption was evaluated. A comparison of the sorbent efficiency of cobalt recovery from thiocyanate solutions was performed for sorbents obtained by impregnation with different solvents (methanol, chloroform). Sorption and kinetic characteristics (isotherm, sorption and desorption kinetics, selectivity) of the sorbents in relation to cobalt in thiocyanate solutions were obtained. The sorbent was shown to possess a high selectivity towards Co in the presence of foreign ions. Sorption and desorption of cobalt were investigated under dynamic conditions. The technique developed for determination of cobalt ions and the specific activity of 60Co radionuclide in aqueous environmental objects enabled quantitative recovery of 60Co against the prevailing background of 137Cs and 152Eu radionuclides accompanied by not less than 20-fold sample concentrating.

A number of impregnated sorbents based on di-(tert-butyldibenzo)-18-crown-6 (DTBDB18C6) and di-(tert-butylcyclohexano)-18-crown-6 (DTBDCH18C6) was obtained using different diluents for the crown ether and the styrene–divinylbenzene support. Sorption characteristics of the sorbents in relation to cobalt ions and 60Co radionuclide in thiocyanate solutions were determined within the range of pH of 1–7. It was found the DTBDB18C6-based sorbents were the most efficient for the sorption of cobalt macro quantities whereas the DTBDCH18C6-based ones for the sorption of 60Co radionuclide, using nitrobenzene as a diluent. A possibility was shown of the complete cobalt desorption by hydrochloric and nitric acid solutions with the concentration of 0.1–1.0 mol L–1.

A number of physicochemical characteristics of ten 1,2,3,4-tetrahydroquinoline derivatives synthesized for the first time, along with their third order Wiener and Randic indices are calculated by quantum chemical methods. Correlations between the topological indices, physicochemical parameters, and retention factors of the mentioned compounds are obtained for conditions of reversed-phase high performance liquid chromatography on porous graphitized carbon.

Approaches that allow one to carry out quantitative analysis of real objects, solutions of nitric acid after contact with sorbents based on N,N,N′,N′-tetra-n-octyldiglycolamide (TODGA), by MALDI mass spectrometry are considered. The internal standard for the quantitative determination of the target component in real samples containing a high excess of inorganic salts is selected. It is found out that reproducible results can be obtained by the external standard method for a large sampling of experimental data, but the internal standard method can significantly improve the accuracy of quantitative analysis. The use of the internal standard makes it possible to eliminate an inaccuracy related to nonuniformity of sample preparation.

The aim of our study was to investigate relationships between quinoline derivatives structure and their retention under reversed-phase liquid chromatography conditions. Retention factors of quinolines were experimentally measured and various geometrical and physicochemical parameters representing analytes molecular structure were calculated. Equations connecting chromatographic data with computed characteristics for the set of 17 investigated compounds were constructed. It was shown that the most precise dependencies include combination of physico-chemical and geometrical parameters.

A series of impregnated sorbents based on di-tert-butyldicyclohexyl-18-crown-6 (DTBDCH18C6), various diluents (1-octanol, nitrobenzene, telomeric alcohol n3), and supports (Porolas-Т, LPS-500, hydrophobized silica gel) for removing tracer and weighable amounts of Sr ions from nitric acid solutions were prepared. The distribution coefficient of tracer amounts of 90Sr on all the synthesized sorbents increases with an increase in the HNO3 concentration in the range 1–7 M. The most pronounced increase in the sorption occurs with an increase in the HNO3 concentration to 3 M. The maximal distribution coefficient of 90Sr (Kd = 158 cm3 g–1) is reached for the sorbent based on DTBDCH18C6 and 1-octanol in 7 M HNO3. Experiments on sorption of weighable amounts of Sr2+ ions show that the static capacity of all the prepared sorbents for Sr in nitric acid solutions amounts to 4.3, 9.2, and 8.4 mg g–1 for the sorbents based on 1-octanol, nitrobenzene, and telomeric alcohol n3, respectively. The synthesized sorbents are suitable for radioanalytical determination of Sr radionuclides in liquid radioactive waste and in radioactively contaminated natural objects.

Impedance measurements for oxide films on zirconium-based E-635 alloy that is used as cladding for fuel rods in nuclear reactors are conducted. The impedance data are shown to provide surface-averaged properties of the oxide films. A galvanostatic method applied for evaluating the alloy’s tendency to localized corrosion enabled us to determine the minimum thickness of the oxide layer, which depended on surface treatment used. The elemental composition of and residual stress at the surface are determined via microfluorescence spectroscopy and X-ray diffraction analysis.

Sorption of tracer amounts of 137Cs and 90Sr radionuclides from model solutions of various compositions onto synthetic titanosilicates, framework ivanyukite and layered SL3, both synthesized at the Center for Nanomaterials Science, Kola Scientific Center, Russian Academy of Sciences, was studied. Synthetic ivanyukite and titanosilicate SL3 well compete with Termoxid-25 ferrocyanide sorbent in the ability to take up cesium from neutral NaNO3 solutions and from a simulated solution of bottom residue from a nuclear power plant with RBMK reactors. The maximal sorption of 137Cs onto ivanyukite is observed at pH 6–7. The dependence of the 137Cs distribution coefficient (K d) on ivanyukite on the concentration of sodium and potassium ions in the solution was studied. Potassium ions affect the cesium sorption more strongly than sodium ions do. In the ability to take up 90Sr, synthetic ivanyukite well competes with synthetic zeolite of type A and with the sorbent based on modified manganese dioxide. The dependences of K d of 90Sr on the concentrations of the Na+ and Ca2+ ions in the solution were determined. Calcium ions affect the strontium sorption more strongly than sodium ions do. Ivanyukite and SL3 show promise as sorbents for removing cesium and strontium radionuclides from multicomponent salt solutions.