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We examined 50 patients with acute myocardial infarction (MI) who in dependence on prescription in the content of basic therapy of sulfhydric group containing angiotensin converting enzyme inhibitors (ACEI) zofenopril and captopril were divided into 2 groups each comprizing 25 patients. We studied dynamics of lipid peroxidation, protective antioxidant systems, the state of endothelial function, systemic inflammation, and endogenous cytoprotective mechanisms - the system of nitric oxide (NO) and stress proteins of HSP70 family - during fist 24 hours of hospitalization, in 1 and 6 months after development of MI. We have found that long-term administration of ACEI promotes lowering of free radical oxidation products what is related to activation of protective antioxidant enzymes and total antioxidant activity of blood serum. Preparations also exert positive effect on the state of protective HSP70 system and parameters of endothelial function.

To compare clinical response to captopril (capoten) vs benazepril (lotensin) in patients with chronic cardiac failure (CCF) as well as their influence on central hemodynamics, some indices of platelet hemostasis, myocardial ischemia degree, exercise tolerance.54 patients with CCF (NYHA FC II and III) entered the trial. 26 patients received captopril (capoten) in a dose 25-75 mg/day (group 1) while 28 patients were given benazepril (lotensin) in a dose 5-30 mg/day for 4 weeks (group 2). Group II was treated for the following 24 weeks. The results were assessed with electro- and echocardiography, bicycle exercise test, platelet aggregation measurement and by clinical symptoms.A positive clinical response was registered to both the drugs which improved the functional class, exercise tolerance, platelet aggregation, reduced the number of arrhythmia and myocardial ischemia episodes. Long-term treatment with lotensin resulted in further improvement of clinical and laboratory indices. Side effects, in which lotensin discontinuation is needed, were absent. Lotensin was more potent than capoten in reducing episodes of ST expression on ECG and episodes of painless myocardial ischemia.