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5. Sentinel lymph node pathological ultrastaging: Final outcome of the Sentix prospective international study in patients with early-stage cervical cancer

Author

Kocian, Roman, Kohler, Christhardt, Bajsova, Sylva, Jarkovsky, Jiri, Zapardiel, Ignacio, Di Martino, Giampaolo, van Lonkhuijzen, Luc, Sehnal, Borek, Sanchez, Octavio Arencibia, Gil-Ibanez, Blanca, Martinelli, Fabio, Presl, Jiri, Minar, Lubos, Pilka, Radovan, Kascak, Peter, Havelka, Pavel, Michal, Martin, van Gorp, Toon, Nemejcova, Kristyna, Dundr, Pavel, and Cibula, David

Published
2024
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8. Unraveling the Molecular Landscape of Uterine Tumor Resembling Ovarian Sex Cord Tumor: Insights From A Clinicopathological, Morphologic, Immunohistochemical, and Molecular Analysis of 35 Cases

Author

Flídrová, Miroslava, Hájková, Nikola, Hojný, Jan, Dvořák, Jiří, Michálková, Romana, Krkavcová, Eva, Laco, Jan, McCluggage, W. Glenn, Giordano, Giovanna, Silini, Enrico Maria, Michalová, Květoslava, Bizoń, Magdalena, Němejcová, Kristýna, Dundr, Pavel, and Kendall Bártů, Michaela

Published
2024
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9. A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrations

Author

Stružinská, Ivana, Hájková, Nikola, Hojný, Jan, Krkavcová, Eva, Michálková, Romana, Dvořák, Jiří, Němejcová, Kristýna, Matěj, Radoslav, Laco, Jan, Drozenová, Jana, Fabian, Pavel, Hausnerová, Jitka, Méhes, Gábor, Škapa, Petr, Švajdler, Marián, Cibula, David, Frühauf, Filip, Bártů, Michaela Kendall, and Dundr, Pavel

Published
2023
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10. A comprehensive immunohistochemical analysis of IMP2 and IMP3 in 542 cases of ovarian tumors

Author

Němejcová, Kristýna, Bártů, Michaela Kendall, Michálková, Romana, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Singh, Naveena, Stolnicu, Simona, Škapa, Petr, Švajdler, Marián, Stružinská, Ivana, Cibula, David, Kocian, Roman, Lax, Sigurd F., McCluggage, W. Glenn, and Dundr, Pavel

Published
2023
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12. Somatic Genomic and Transcriptomic Characterization of Primary Ovarian Serous Borderline Tumors and Low-Grade Serous Carcinomas

Author

Stružinská, Ivana, Hájková, Nikola, Hojný, Jan, Krkavcová, Eva, Michálková, Romana, Bui, Quang Hiep, Matěj, Radoslav, Laco, Jan, Drozenová, Jana, Fabian, Pavel, Škapa, Petr, Špůrková, Zuzana, Cibula, David, Frühauf, Filip, Jirásek, Tomáš, Zima, Tomáš, Méhes, Gábor, Kendall Bártů, Michaela, Němejcová, Kristýna, and Dundr, Pavel

Published
2024
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13. Mucinous Tumors, Pathology of the Ovary

Author

Dundr, Pavel, Hájková, Nikola, Bártů, Michaela, Němejcová, Kristýna, Stružinská, Ivana, van Krieken, J. H. J. M., Series Editor, Stolnicu, Simona, editor, and Ali-Fehmi, Rouba, editor

Published
2023
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15. Microsatellite instability in non-endometrioid ovarian epithelial tumors: a study of 400 cases comparing immunohistochemistry, PCR, and NGS based testing with mutation status of MMR genes

Author

Hájková, Nikola, Bártů, Michaela Kendall, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Frühauf, Filip, Hausnerová, Jitka, Hojný, Jan, Krkavcová, Eva, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, McCluggage, Wilson Glenn, Stružinská, Ivana, and Dundr, Pavel

Published
2023
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16. Refined criteria for p53 expression in ovarian mucinous tumours are highly concordant with TP53 mutation status, but p53 expression/TP53 status lack prognostic significance

Author

Dundr, Pavel, Hájková, Nikola, Kendall Bártů, Michaela, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Frühauf, Filip, Hausnerová, Jitka, Hojný, Jan, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, McCluggage, W. Glenn, and Stružinská, Ivana

Published
2023
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17. Primary Mucinous Tumors of the Ovary: An Interobserver Reproducibility and Detailed Molecular Study Reveals Significant Overlap Between Diagnostic Categories

Author

Dundr, Pavel, Bártů, Michaela, Bosse, Tjalling, Bui, Quang Hiep, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Hojný, Jan, Hájková, Nikola, Jakša, Radek, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Šafanda, Adam, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, Stružinská, Ivana, and McCluggage, W. Glenn

Published
2023
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18. The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance

Author

Dundr, Pavel, Bazalová, Barbora, Bártů, Michaela, Bosse, Tjalling, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Jakša, Radek, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, McCluggage, W. Glenn, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Škapa, Petr, Švajdler, Marián, and Stružinská, Ivana

Published
2022
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23. Benign Lesions of the Vagina

Author

Dundr, Pavel, Němejcová, Kristýna, Bártů, Michaela, Zheng, Wenxin, editor, Fadare, Oluwole, editor, Quick, Charles Matthew, editor, Shen, Danhua, editor, and Guo, Donghui, editor

Published
2019
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27. Neuroendocrine Marker Expression in Primary Non-neuroendocrine Epithelial Tumors of the Ovary: A Study of 551 Cases.

Author

Bártů, Michaela Kendall, Němejcová, Kristýna, Michálková, Romana, Quang Hiep Bui, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Šafanda, Adam, Singh, Naveena, Škapa, Petr, Špůrková, Zuzana, Stolnicu, Simona, Švajdler, Marián, Lax, Sigurd F., McCluggage, W. Glenn, and Dundr, Pavel

Published
2024
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29. Stratification of lymph node metastases as macrometastases, micrometastases, or isolated tumor cells has no clinical implication in patients with cervical cancer: Subgroup analysis of the SCCAN project

Author

Dostálek, Lukáš, Benešová, Klára, Klát, Jaroslav, Kim, Sarah H., Falconer, Henrik, Kostun, Jan, dos Reis, Ricardo, Zapardiel, Ignacio, Landoni, Fabio, Ortiz, David Isla, van Lonkhuijzen, Luc R. C. W., Lopez, Aldo, Odetto, Diego, Borčinová, Martina, Jarkovsky, Jiri, Salehi, Sahar, Němejcová, Kristýna, Bajsová, Sylva, Park, Kay J., Javůrková, Veronika, Abu-Rustum, Nadeem R., Dundr, Pavel, Cibula, David, Dostalek, L, Benesova, K, Klat, J, Kim, S, Falconer, H, Kostun, J, dos Reis, R, Zapardiel, I, Landoni, F, Ortiz, D, van Lonkhuijzen, L, Lopez, A, Odetto, D, Borcinova, M, Jarkovsky, J, Salehi, S, Nemejcova, K, Bajsova, S, Park, K, Javurkova, V, Abu-Rustum, N, Dundr, P, Cibula, D, Obstetrics and Gynaecology, and CCA - Cancer Treatment and Quality of Life

Subjects
History, Low volume metastasis, Macrometastasi, Polymers and Plastics, Prognosi, Disease-free survival, Isolated tumor cells, Macrometastasis, Obstetrics and Gynecology, Isolated tumor cell, Classification, Prognosis, Industrial and Manufacturing Engineering, Low volume metastasi, Micrometastasis, Micrometastasi, Oncology, Cervical cancer, Histopathological ultrastaging, Business and International Management, Sentinel lymph node
Abstract

Background: In cervical cancer, presence of lymph-node macrometastases (MAC) is a major prognostic factor and an indication for adjuvant treatment. However, since clinical impact of micrometastases (MIC) and isolated tumor-cells (ITC) remains controversial, we sought to identify a cut-off value for the metastasis size not associated with negative prognosis. Methods: We analyzed data from 967 cervical cancer patients (T1a1L1-T2b) registered in the SCCAN (Surveillance in Cervical CANcer) database, who underwent primary surgical treatment, including sentinel lymph-node (SLN) biopsy with pathological ultrastaging. The size of SLN metastasis was considered a continuous variable and multiple testing was performed for cut-off values of 0.01-1.0 mm. Disease-free survival (DFS) was compared between N0 and subgroups of N1 patients defined by cut-off ranges. Results: LN metastases were found in 172 (18%) patients, classified as MAC, MIC, and ITC in 79, 54, and 39 patients, respectively. DFS was shorter in patients with MAC (HR 2.20, P = 0.003) and MIC (HR 2.87, P < 0.001), while not differing between MAC/MIC (P = 0.484). DFS in the ITC subgroup was neither different from N0 (P = 0.127) nor from MIC/MAC subgroups (P = 0.449). Cut-off analysis revealed significantly shorter DFS compared to N0 in all subgroups with metastases ≥0.4 mm (HR 2.311, P = 0.04). The significance of metastases

Published
2023

30. Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases

Author

Dundr, Pavel, primary, Machado-Lopez, Alba, additional, Mas, Aymara, additional, Věcková, Zuzana, additional, Mára, Michal, additional, Richtárová, Adéla, additional, Matěj, Radoslav, additional, Stružinská, Ivana, additional, Kendall Bártů, Michaela, additional, Němejcová, Kristýna, additional, Dvořák, Jiří, additional, and Hojný, Jan, additional

Published
2023
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31. Neuroendocrine Marker Expression in Primary Non-neuroendocrine Epithelial Tumors of the Ovary: A Study of 551 Cases

Author

Kendall Bártů, Michaela, Němejcová, Kristýna, Michálková, Romana, Bui, Quang Hiep, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Šafanda, Adam, Singh, Naveena, Škapa, Petr, Špůrková, Zuzana, Stolnicu, Simona, Švajdler, Marián, Lax, Sigurd F., McCluggage, W. Glenn, and Dundr, Pavel

Abstract

Expression of neuroendocrine (NE) markers in primary ovarian non-NE epithelial tumors has rarely been evaluated. The aim of our study was to evaluate the expression of the most widely used NE markers in these neoplasms and to determine any prognostic significance of NE marker expression. The cohort consisted of 551 primary ovarian tumors, including serous borderline tumors, low-grade serous carcinomas, high-grade serous carcinomas (HGSC), clear cell carcinomas, endometroid carcinomas, mucinous borderline tumors, and mucinous carcinomas. Immunohistochemical analysis was performed using antibodies against INSM1, synaptophysin, chromogranin, and CD56 on tissue microarray. Positivity for INSM1, synaptophysin, chromogranin, and CD56 was most frequently observed in mucinous tumors (48.7%, 26.0%, 41.5%, and 100%, respectively). The positivity for these NE markers was mostly restricted to nonmucinous elements distributed throughout the tumor. The mucinous borderline tumor and mucinous carcinomas groups had similar proportions of positivity (mucinous borderline tumor: 53%, mucinous carcinomas: 39%). In the other tumor types, except for HGSC, there was only focal expression (5%–10%) or negativity for NE markers. HGSC showed high CD56 expression (in 26% of cases). Survival analysis was only performed for CD56 in HGSC as this was the only group with sufficient positive cases, and it showed no prognostic significance. Except for mucinous tumors, expression of NE markers in non-NE ovarian epithelial tumors is low. CD56 expression in HGSC occurs frequently but is without diagnostic or prognostic value.

Published
2024
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38. Primary retroperitoneal nodal endometrioid carcinoma associated with Lynch syndrome: A case report

Author

Fischerova, Daniela, primary, Scovazzi, Umberto, additional, Sousa, Natacha, additional, Hovhannisyan, Tatevik, additional, Burgetova, Andrea, additional, Dundr, Pavel, additional, Němejcová, Kristýna, additional, Bennett, Rosalie, additional, Vočka, Michal, additional, Frühauf, Filip, additional, Kocian, Roman, additional, Indrielle-Kelly, Tereza, additional, and Cibula, David, additional

Published
2023
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39. Additional file 1 of A comprehensive immunohistochemical analysis of 26 markers in 250 cases of serous ovarian tumors

Author

Němejcová, Kristýna, Šafanda, Adam, Bártů, Michaela Kendall, Michálková, Romana, Drozenová, Jana, Fabian, Pavel, Hausnerová, Jitka, Laco, Jan, Matěj, Radoslav, Méhes, Gábor, Škapa, Petr, Stružinská, Ivana, and Dundr, Pavel

Abstract

Additional file 1: TableS1. List of antibodies. TableS2. Overview of optimal cut-offs for the selected markers distinguishingbetween HGSC vs. LGSC and LGSC vs. mSBT. Suitable markers are marked in bold,based on sensitivity and specificity.

Published
2023
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41. 2022-RA-222-ESGO Quality of life after extended pelvic exenterations

Author

Lednický, Štefan, primary, Hoschlová, Eva, additional, Sláma, Jiří, additional, Wiesnerová, Markéta, additional, Mitáš, Petr, additional, Matějovský, Zdeněk, additional, Schneiderová, Michaela, additional, Dundr, Pavel, additional, Němejcová, Kristýna, additional, Burgetová, Andrea, additional, Zámečník, Libor, additional, Vočka, Michal, additional, Kocián, Roman, additional, Fruehauf, Filip, additional, Dostálek, Lukáš, additional, Fischerová, Daniela, additional, Borčinová, Martina, additional, and Cibula, David, additional

Published
2022
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42. Refined criteria for p53 expression in ovarian mucinous tumours are highly concordant with TP53mutation status, but p53 expression/TP53status lack prognostic significance

Author

Dundr, Pavel, Hájková, Nikola, Kendall Bártů, Michaela, Cibula, David, Drozenová, Jana, Fabian, Pavel, Fadare, Oluwole, Frühauf, Filip, Hausnerová, Jitka, Hojný, Jan, Laco, Jan, Lax, Sigurd F., Matěj, Radoslav, Méhes, Gábor, Michálková, Romana, Němejcová, Kristýna, Singh, Naveena, Stolnicu, Simona, Švajdler, Marián, Zima, Tomáš, McCluggage, W. Glenn, and Stružinská, Ivana

Abstract

In gynecological neoplasms, immunohistochemical (IHC) expression of p53 is generally an accurate predictor of TP53mutation status if correctly interpreted by the pathologist. However, the literature concerning cut-offs, frequency and prognostic significance of p53 staining in ovarian mucinous tumours is limited and heterogeneous. We performed an analysis of 123 primary ovarian mucinous tumours including mucinous borderline tumours (MBT), mucinous carcinomas (MC), and tumours with equivocal features between MBT and MC. We assessed p53 expression for the three recognised patterns of aberrant staining in ovarian carcinoma [overexpression (‘all’), null and cytoplasmic] but using a recently suggested cut-off for aberrant overexpression in ovarian mucinous tumours (strong nuclear p53 staining in ≥12 consecutive tumour cells) and correlated the results with next generation sequencing (NGS) in all qualitatively sufficient cases (92/123). Aberrant p53 expression was present in 25/75 (33.3%) MBT, 23/33 (69.7%) MC (75% of MC with expansile invasion and 61.5% with infiltrative invasion), and 10/15 (66.7%) tumours equivocal between MBT and MC. Regarding the 92 tumours with paired IHC and mutation results, 86 showed concordant results and six cases were discordant. Three discordant MBT cases showed aberrant expression but were TP53wild-type on sequencing. Three cases had normal p53 expression but contained a TP53mutation. Overall, IHC predicted the TP53mutation status with high sensitivity (94.1%) and specificity (92.7%). The accuracy of IHC was 93.5% with a positive predictive value of 94.1% and a negative predictive value of 92.7%. When comparing MC cases with wild-type TP53versus those with TP53mutation, there were no significant differences concerning disease-free survival, local recurrence-free survival, or metastases-free survival (p>0.05). In the MBT subgroup, there were no events for survival analyses. In conclusion, using an independent large sample set of ovarian mucinous tumours, the results of our study confirm that the suggested refined cut-off of strong nuclear p53 staining in ≥12 consecutive tumour cells reflect high accuracy, sensitivity and specificity for an underlying TP53mutation but the TP53mutation status has no prognostic significance in either MC or MBT.

Published
2023
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44. Early-stage cervical cancer: Tumor delineation by magnetic resonance imaging and ultrasound — A European multicenter trial

Author

Epstein, Elisabeth, Testa, Antonia, Gaurilcikas, Adrius, Di Legge, Alessia, Ameye, Liveke, Atstupenaite, Vaida, Valentini, Anna Lia, Gui, Benedetta, Wallengren, Nils-Olof, Pudaric, Sonja, Cizauskas, Arvydas, Måsbäck, Anna, Zannoni, Gian Franco, Kannisto, Päivi, Zikan, Michal, Pinkavova, Ivana, Burgetova, Andrea, Dundr, Pavel, Nemejcova, Kristyna, Cibula, David, and Fischerova, Daniela

Published
2013
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45. The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis

Author

Laco, Jan, Sieglová, Kateřina, Vošmiková, Hana, Dundr, Pavel, Němejcová, Kristýna, Michálek, Jaroslav, Čelakovský, Petr, Chrobok, Viktor, Mottl, Radovan, Mottlová, Alena, Tuček, Luboš, Slezák, Radovan, Chmelařová, Marcela, Sirák, Igor, Vošmik, Milan, and Ryška, Aleš

Published
2015
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47. Stratification of Lymph Node Metastases as Macrometastases, Micrometastases, Or Isolated Tumor Cells Has No Clinical Implication in Patients with Cervical Cancer: Subgroup Analysis of the SCCAN Project

Author

Dostálek, Lukáš, primary, Benešová, Klára, additional, Klát, Jaroslav, additional, Kim, Sarah H., additional, Falconer, Henrik, additional, Kostun, Jan, additional, dos Reis, Ricardo, additional, Zapardiel, Ignacio, additional, Landoni, Fabio, additional, Ortiz, David Isla, additional, van Lonkhuijzen, Luc R.C.W., additional, Lopez, Aldo, additional, Odetto, Diego, additional, Borčinová, Martina, additional, Parenica, Jiri, additional, Salehi, Sahar, additional, Němejcová, Kristýna, additional, Bajsová, Sylva, additional, Park, Kay J., additional, Javůrková, Veronika, additional, Abu-Rustum, Nadeem R., additional, Dundr, Pavel, additional, and Cibula, David, additional

Published
2022
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48. Uterine cellular leiomyomas are characterized by common HMGA2 aberrations, followed by chromosome 1p deletion and MED12 mutation: morphological, molecular, and immunohistochemical study of 52 cases

Author

Dundr, Pavel, primary, Gregová, Mária, additional, Hojný, Jan, additional, Krkavcová, Eva, additional, Michálková, Romana, additional, Němejcová, Kristýna, additional, Bártů, Michaela, additional, Hájková, Nikola, additional, Laco, Jan, additional, Mára, Michal, additional, Richtárová, Adéla, additional, Zima, Tomáš, additional, and Stružinská, Ivana, additional

Published
2021
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49. A comprehensive analysis of the expression, epigenetic and genetic changes of HNF1B and ECI2 in 122 cases of high-grade serous ovarian carcinoma

Author

Němejcová, Kristýna, Bártů, Michaela, Hojný, Jan, Hájková, Nikola, Michálková, Romana, Krkavcová, Eva, Stružinská, Ivana, Bui, Hiep Quang, Dundr, Pavel, Cibula, David, and Jirsová, Kateřina

Subjects
ovarian carcinoma, hepatocyte nuclear factor 1β, mRNA, high-grade serous carcinoma, enoyl-CoA (Δ) isomerase 2, immunohistochemistry, Articles, methylation, mutation analysis
Abstract

High-grade serous ovarian cancer (HGSC) is the most common subtype of ovarian cancer, with a poor prognosis; however, most studies concerning ovarian carcinoma have focused mainly on clear cell carcinoma. The involvement of hepatocyte nuclear factor 1β (HNF1B) in the carcinogenesis of HGSC has not yet been fully elucidated. To the best of our knowledge, the present study is the first to analyse the expression of the possible downstream target of HNF1B, enoyl-CoA (Δ) isomerase 2 (ECI2), in HGSC. The present study performed a comprehensive analysis of HNF1B mRNA and protein expression, and epigenetic and genetic changes, as well as an analysis of ECI2 mRNA and protein expression in 122 cases of HGSC. HNF1B protein expression was detected in 28/122 cases, and was positively associated with lymphovascular invasion (P=0.025). Protein expression of ECI2 was detected in 115/122 cases, but no associations with clinicopathological variables were revealed. Therefore, ECI2 does not seem to function as a suitable prognostic marker for HGSC. In the sample set, a positive correlation between HNF1B and ECI2 protein expression was detected (P=0.005). HNF1B mRNA was also positively correlated with HNF1B protein expression (P=0.001). HNF1B promoter methylation was detected in 26/67 (38.8%) of cases. A novel pathogenic somatic HNF1B mutation was detected in 1/61 (1.6%) of the analysed HGSC cases. No other correlations between the examined SNPs (rs4430796, rs757210 and rs7405776), HNF1B promoter methylation, HNF1B/ECI2 expression or clinicopathological characteristics were found.

Published
2021

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