1. Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function.
- Author
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Gerber D, Ghidinelli M, Tinelli E, Somandin C, Gerber J, Pereira JA, Ommer A, Figlia G, Miehe M, Nägeli LG, Suter V, Tadini V, Sidiropoulos PN, Wessig C, Toyka KV, and Suter U
- Subjects
- Animals, Axons metabolism, Cell Death, Cell Differentiation, Cell Survival, Cytokinesis, Mice, Mitosis, Myelin Sheath metabolism, Peripheral Nerves metabolism, Transcriptome genetics, Dynamin II metabolism, Oligodendroglia metabolism, Schwann Cells metabolism
- Abstract
Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesicular trafficking. Here, we genetically ablated Dnm2 in Schwann cells (SCs) and in oligodendrocytes of mice. Dnm2 deletion in developing SCs resulted in severely impaired axonal sorting and myelination onset. Induced Dnm2 deletion in adult SCs caused a rapidly-developing peripheral neuropathy with abundant demyelination. In both experimental settings, mutant SCs underwent prominent cell death, at least partially due to cytokinesis failure. Strikingly, when Dnm2 was deleted in adult SCs, non-recombined SCs still expressing DNM2 were able to remyelinate fast and efficiently, accompanied by neuropathy remission. These findings reveal a remarkable self-healing capability of peripheral nerves that are affected by SC loss. In the central nervous system, however, we found no major defects upon Dnm2 deletion in oligodendrocytes., Competing Interests: DG, MG, ET, CS, JG, JP, AO, GF, MM, LN, VS, VT, PS, CW, KT, US No competing interests declared, (© 2019, Gerber et al.)
- Published
- 2019
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