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10,644 results on '"Myung-Ho In"'

1. Cardiorespiratory dynamics in the brain: Review on the significance of cardiovascular and respiratory correlates in functional MRI signal

Author

Mahathi Kandimalla, Seokbeen Lim, Jay Thakkar, Sannidhi Dewan, Daehun Kang, Myung-Ho In, Hang Joon Jo, Dong Pyo Jang, Zuzana Nedelska, Maria I. Lapid, Yunhong Shu, Cheon-Pyung, Petrice M. Cogswell, Val J. Lowe, Jeyeon Lee, and Hoon-Ki Min

Subjects
Cardiopulmonary, Cardiorespiratory dynamics, Integrative physiology, fMRI (Functional Magnetic Resonance Imaging), BOLD (Blood Oxygen Level-Dependent), rsfMRI (Resting-State fMRI), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Cardiorespiratory signals have long been treated as ''noise'' in functional magnetic resonance imaging (fMRI) research, with the goal of minimizing their impact to isolate neural activity. However, there is a growing recognition that these signals, once seen as confounding variables, provide valuable insights into brain function and overall health. This shift reflects the dynamic interaction between the cardiovascular, respiratory, and neural systems, which together support brain activity. In this review, we explore the role of cardiorespiratory dynamics—such as heart rate variability (HRV), respiratory sinus arrhythmia (RSA), and changes in blood flow, oxygenation, and carbon dioxide levels—embedded within fMRI signals. These physiological signals reflect critical aspects of neurovascular coupling and are influenced by factors such as physiological stress, breathing patterns, and age-related changes. We also discuss the complexities of distinguishing these signals from neuronal activity in fMRI data, given their significant contribution to signal variability and interactions with cerebrospinal fluid (CSF). Recognizing the influence of these cardiorespiratory dynamics is crucial for improving the interpretation of fMRI data, shedding light on heart-brain and respiratory-brain connections, and enhancing our understanding of circulation, oxygen delivery, and waste elimination within the brain.

Published
2025
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2. Improved Resting-State Functional MRI Using Multi-Echo Echo-Planar Imaging on a Compact 3T MRI Scanner with High-Performance Gradients

Author

Daehun Kang, Myung-Ho In, Hang Joon Jo, Maria A. Halverson, Nolan K. Meyer, Zaki Ahmed, Erin M. Gray, Radhika Madhavan, Thomas K. Foo, Brice Fernandez, David F. Black, Kirk M. Welker, Joshua D. Trzasko, John Huston, Matt A. Bernstein, and Yunhong Shu

Subjects
fMRI, BOLD, resting state, multi-echo EPI, compact 3T, gradient system, Chemical technology, TP1-1185
Abstract

In blood-oxygen-level-dependent (BOLD)-based resting-state functional (RS-fMRI) studies, usage of multi-echo echo-planar-imaging (ME-EPI) is limited due to unacceptable late echo times when high spatial resolution is used. Equipped with high-performance gradients, the compact 3T MRI system (C3T) enables a three-echo whole-brain ME-EPI protocol with smaller than 2.5 mm isotropic voxel and shorter than 1 s repetition time, as required in landmark fMRI studies. The performance of the ME-EPI was comprehensively evaluated with signal variance reduction and region-of-interest-, seed- and independent-component-analysis-based functional connectivity analyses and compared with a counterpart of single-echo EPI with the shortest TR possible. Through the multi-echo combination, the thermal noise level is reduced. Functional connectivity, as well as signal intensity, are recovered in the medial orbital sulcus and anterior transverse collateral sulcus in ME-EPI. It is demonstrated that ME-EPI provides superior sensitivity and accuracy for detecting functional connectivity and/or brain networks in comparison with single-echo EPI. In conclusion, the high-performance gradient enabled high-spatial-temporal resolution ME-EPI would be the method of choice for RS-fMRI study on the C3T.

Published
2023
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3. Impact of prospective motion correction, distortion correction methods and large vein bias on the spatial accuracy of cortical laminar fMRI at 9.4 Tesla

Author

Jonas Bause, Jonathan R. Polimeni, Johannes Stelzer, Myung-Ho In, Philipp Ehses, Pablo Kraemer-Fernandez, Ali Aghaeifar, Eric Lacosse, Rolf Pohmann, and Klaus Scheffler

Subjects
Laminar fMRI, Gradient echo EPI, Prospective motion correction, Distortion correction, Ultra-high field, Macro-vascular bias, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Functional imaging with sub-millimeter spatial resolution is a basic requirement for assessing functional MRI (fMRI) responses across different cortical depths and is used extensively in the emerging field of laminar fMRI. Such studies seek to investigate the detailed functional organization of the brain and may develop to a new powerful tool for human neuroscience. However, several studies have shown that measurement of laminar fMRI responses can be biased by the image acquisition and data processing strategies. In this work, measurements with three different gradient-echo EPI BOLD fMRI protocols with a voxel size down to 650 ​μm isotropic were performed at 9.4 ​T. We estimated how prospective motion correction can help to improve spatial accuracy by reducing the number of spatial resampling steps in postprocessing. In addition, we demonstrate key requirements for accurate geometric distortion correction to ensure that distortion correction maps are properly aligned to the functional data and that strong variations of distortions near large veins can lead to signal overlays which cannot be corrected for during postprocessing. Furthermore, this study illustrates the spatial extent of bias induced by pial and other larger veins in laminar BOLD experiments. Since these issues under investigation affect studies performed with more conventional spatial resolutions, the methods applied in this work may also help to improve the understanding of the BOLD signal more broadly.

Published
2020
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4. Resting‐state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brain

Author

Shinho Cho, Jan T. Hachmann, Irena Balzekas, Myung‐Ho In, Lindsey G. Andres‐Beck, Kendall H. Lee, Hoon‐Ki Min, and Hang Joon Jo

Subjects
blood‐oxygenation‐level‐dependent hemodynamic response, deep brain stimulation, functional connectivity change, functional magnetic resonance imaging, network effect, nucleus accumbens, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Introduction While the clinical efficacy of deep brain stimulation (DBS) the treatment of motor‐related symptoms is well established, the mechanism of action of the resulting cognitive and behavioral effects has been elusive. Methods By combining functional magnetic resonance imaging (fMRI) and DBS, we investigated the pattern of blood‐oxygenation‐level‐dependent (BOLD) signal changes induced by stimulating the nucleus accumbens in a large animal model. Results We found that diffused BOLD activation across multiple functional networks, including the prefrontal, limbic, and thalamic regions during the stimulation, resulted in a significant change in inter‐regional functional connectivity. More importantly, the magnitude of the modulation was closely related to the strength of the inter‐regional resting‐state functional connectivity. Conclusions Nucleus accumbens stimulation affects the functional activity in networks that underlie cognition and behavior. Our study provides an insight into the nature of the functional connectivity, which mediates activation effect via brain networks.

Published
2019
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5. Mapping BOLD Activation by Pharmacologically Evoked Tremor in Swine

Author

Jeyeon Lee, Hang Joon Jo, Inyong Kim, Jihyun Lee, Hoon-Ki Min, Myung-Ho In, Emily J. Knight, and Su-Youne Chang

Subjects
tremor, essential tremor, harmaline-induced tremor, pharmacological fMRI, swine model, pig, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Harmaline-induced tremor is one of the most commonly utilized disease models for essential tremor (ET). However, the underlying neural networks involved in harmaline-induced tremor and the degree to which these are a representative model of the pathophysiologic mechanism of ET are incompletely understood. In this study, we evaluated the functional brain network effects induced by systemic injection of harmaline using pharmacological functional magnetic resonance imaging (ph-fMRI) in the swine model. With harmaline administration, we observed significant activation changes in cerebellum, thalamus, and inferior olivary nucleus (ION). In addition, inter-regional correlations in activity between cerebellum and deep cerebellar nuclei and between cerebellum and thalamus were significantly enhanced. These harmaline-induced effects gradually decreased with repeated administration of drug, replicating the previously demonstrated ‘tolerance’ effect. This study demonstrates that harmaline-induced tremor is associated with activity changes in brain regions previously implicated in humans with ET. Thus, harmaline-induction of tremor in the swine may be a useful model to explore the neurological effects of novel therapeutic agents and/or neuromodulation techniques for ET.

Published
2019
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11. Distortion correction in EPI using an extended PSF method with a reversed phase gradient approach.

Author

Myung-Ho In, Oleg Posnansky, Erik B Beall, Mark J Lowe, and Oliver Speck

Subjects
Medicine, Science
Abstract

In echo-planar imaging (EPI), such as commonly used for functional MRI (fMRI) and diffusion-tensor imaging (DTI), compressed distortion is a more difficult challenge than local stretching as spatial information can be lost in strongly compressed areas. In addition, the effects are more severe at ultra-high field (UHF) such as 7T due to increased field inhomogeneity. To resolve this problem, two EPIs with opposite phase-encoding (PE) polarity were acquired and combined after distortion correction. For distortion correction, a point spread function (PSF) mapping method was chosen due to its high correction accuracy and extended to perform distortion correction of both EPIs with opposite PE polarity thus reducing the PSF reference scan time. Because the amount of spatial information differs between the opposite PE datasets, the method was further extended to incorporate a weighted combination of the two distortion-corrected images to maximize the spatial information content of a final corrected image. The correction accuracy of the proposed method was evaluated in distortion-corrected data using both forward and reverse phase-encoded PSF reference data and compared with the reversed gradient approaches suggested previously. Further we demonstrate that the extended PSF method with an improved weighted combination can recover local distortions and spatial information loss and be applied successfully not only to spin-echo EPI, but also to gradient-echo EPIs acquired with both PE directions to perform geometrically accurate image reconstruction.

Published
2015
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15. Quantum interference probed by the thermovoltage in Sb-doped Bi2Se3 nanowires

Author

Kwon, Duhyuk, Kim, Bum-Kyu, Doh, Yong-Joo, Yu, Dong, Song, Jonghyun, and Bae, Myung-Ho

Subjects
Quantum Physics, Engineering, Physical Sciences, Nanotechnology, Condensed Matter Physics, Energy materials, Quantum solids, Thermal property
Abstract

The magnetic-flux-dependent dispersions of sub-bands in topologically protected surface states of a topological insulator nanowire manifest as Aharonov-Bohm oscillations (ABOs) observed in conductance measurements, reflecting the Berry's phase of π because of the spin-helical surface states. Here, we used thermoelectric measurements to probe a variation in the density of states at the Fermi level of the surface state of a topological insulator nanowire (Sb-doped Bi2Se3) under external magnetic fields and an applied gate voltage. The ABOs observed in the magnetothermovoltage showed 180° out-of-phase oscillations depending on the gate voltage values, which can be used to tune the Fermi wave number and the density of states at the Fermi level. The temperature dependence of the ABO amplitudes showed that the phase coherence was kept to T = 15 K. We suggest that thermoelectric measurements could be applied for investigating the electronic structure at the Fermi level in various quantum materials.

Published
2023

16. Intravascular imaging-guided percutaneous coronary intervention in patients with acute myocardial infarction and cardiogenic shock

Author

Joh, Hyun Sung, Lee, Seung Hun, Jo, Jinhwan, Kim, Hyun Kuk, Lim, Woo-Hyun, Kim, Hack-Lyoung, Seo, Jae-Bin, Chung, Woo-Young, Kim, Sang-Hyun, Zo, Joo-Hee, Kim, Myung-A., Kim, Min Chul, Kim, Ju Han, Hong, Young Joon, Ahn, Young Keun, Jeong, Myung Ho, Hur, Seung Ho, Kim, Doo Il, Chang, Kiyuk, Park, Hun Sik, Bae, Jang-Whan, Jeong, Jin-Ok, Park, Yong Hwan, Yun, Kyeong Ho, Yoon, Chang-Hwan, Kim, Yisik, Hwang, Jin-Yong, Kim, Hyo-Soo, Hong, David, Kwon, Woochan, Choi, Ki Hong, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, and Lee, Joo Myung

Published
2024
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17. Intervención coronaria percutánea guiada por imagen intravascular en pacientes con infarto agudo de miocardio y shock cardiogénico

Author

Joh, Hyun Sung, Lee, Seung Hun, Jo, Jinhwan, Kim, Hyun Kuk, Lim, Woo-Hyun, Kim, Hack-Lyoung, Seo, Jae-Bin, Chung, Woo-Young, Kim, Sang-Hyun, Zo, Joo-Hee, Kim, Myung-A., Kim, Min Chul, Kim, Ju Han, Hong, Young Joon, Ahn, Young Keun, Jeong, Myung Ho, Hur, Seung Ho, Kim, Doo Il, Chang, Kiyuk, Park, Hun Sik, Bae, Jang-Whan, Jeong, Jin-Ok, Park, Yong Hwan, Yun, Kyeong Ho, Yoon, Chang-Hwan, Kim, Yisik, Hwang, Jin-Yong, Kim, Hyo-Soo, Hong, David, Kwon, Woochan, Choi, Ki Hong, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, and Lee, Joo Myung

Published
2024
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19. Preliminary Investigation on Efficacy and Safety of Substance P-Coated Stent for Promoting Re-Endothelialization: A Porcine Coronary Artery Restenosis Model

Author

Park, Dae Sung, Oh, Seok, Jin, Yu Jeong, Na, Mi Hyang, Kim, Munki, Kim, Jeong Ha, Hyun, Dae Young, Cho, Kyung Hoon, Hong, Young Joon, Kim, Ju Han, Ahn, Youngkeun, Hermida-Prieto, Manuel, Vázquez-Rodríguez, José Manuel, Gutiérrez-Chico, Juan Luis, Mariñas-Pardo, Luis, Lim, Kyung Seob, Park, Jun-Kyu, Byeon, Dae-Heung, Cho, Young-Nan, Kee, Seung-Jung, Sim, Doo Sun, and Jeong, Myung Ho

Published
2024
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20. Abstract 4139844: Clinical Relevance of FFR-guided PCI According to Left Ventricular Systolic Function in Patients with Acute Myocardial Infarction and Multivessel Disease

Author

Lee, Yong-Kyu, Lee, Seung Hun, Kim, Hangyul, Ahn, Joon Ho, Cho, Kyung-Hoon, Kim, Min Chul, Sim, Doo Sun, Lee, Joo Myung, Hong, David, Hahn, Joo-Yong, Kim, Hyun Kuk, Park, Keun Ho, Choo, Eun Ho, Kim, Chan Joon, Ahn, Gyun, Doh, Joon-Hyung, Lee, Sang Yeub, Park, Sang Don, Lee, Hyun-Jong, Kang, Min Gyu, Nam, Chang-Wook, Choi, Ki Hong, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Choi, Seung-Hyuk, Kim, Ju Han, Ahn, Youngkeun, Jeong, Myung Ho, Gwon, Hyeon-Cheol, Koh, Jin-sin, and Hong, Young Joon

Published
2024
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26. Clinical outcomes of adjusted-dose versus standard-dose prasugrel in East Asian patients with acute myocardial infarction

Author

Honda, Satoshi, Lee, Sangyeub, Cho, Kyung Hoon, Takegami, Misa, Nishihira, Kensaku, Kojima, Sunao, Asaumi, Yasuhide, Saji, Mike, Yamashita, Jun, Hibi, Kiyoshi, Takahashi, Jun, Sakata, Yasuhiko, Takayama, Morimasa, Sumiyoshi, Tetsuya, Ogawa, Hisao, Kimura, Kazuo, Sim, Doo Sun, Kim, Hyun Kuk, Kim, Weon, Ahn, Youngkeun, Jeong, Myung Ho, and Yasuda, Satoshi

Published
2024
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30. Timing of fractional flow reserve-guided complete revascularization in patients with ST-segment elevation myocardial infarction with multivessel disease: Rationale and design of the OPTION-STEMI trial

Author

Kim, Min Chul, Ahn, Joon Ho, Hyun, Dae Young, Lim, Yongwhan, Lee, Seung Hun, Oh, Seok, Cho, Kyung Hoon, Sim, Doo Sun, Hong, Young Joon, Kim, Ju Han, Jeong, Myung Ho, Cho, Jang Hyun, Lee, Sang-Rok, Kang, Dong Oh, Hwang, Jin-Yong, Youn, Young Jin, Jeong, Young-Hoon, Park, Yongwhi, Kim, Dong-Bin, Choo, Eun-Ho, Kim, Chan Joon, Kim, Weon, Rhew, Jay Young, Lee, Jung-Hee, Yoo, Sang-Yong, and Ahn, Youngkeun

Published
2024
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40. Prognosis after discontinuing renin angiotensin aldosterone system inhibitor for heart failure with restored ejection fraction after acute myocardial infarction

Author

Lee, Seung Hun, Rhee, Tae-Min, Shin, Doosup, Hong, David, Choi, Ki Hong, Kim, Hyun Kuk, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuck, Chae, Shung Chull, Cho, Myeong-Chan, Kim, Chong Jin, Kim, Ju Han, Kim, Hyo-Soo, Gwon, Hyeon-Cheol, Jeong, Myung Ho, and Lee, Joo Myung

Published
2023
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41. Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder

Author

Kim, Bora, Ha, Mina, Kim, Young Shin, Koh, Yun-Joo, Dong, Shan, Kwon, Ho-Jang, Kim, Young-Suk, Lim, Myung-Ho, Paik, Ki-Chung, Yoo, Seung-Jin, Kim, Hosanna, Hong, Patricia S, Sanders, Stephan J, and Leventhal, Bennett L

Subjects
Biomedical and Clinical Sciences, Psychology, Behavioral and Social Science, Autism, Pediatric, Genetics, Tobacco Smoke and Health, Intellectual and Developmental Disabilities (IDD), Tobacco, Mental Health, Prevention, Brain Disorders, 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Mental health, Autism Spectrum Disorder, Causality, Family, Female, Humans, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Smoking, autism spectrum disorders, environmental factors, risk factor epidemiology, Specialist Studies in Education, Cognitive Sciences, Developmental & Child Psychology, Biomedical and clinical sciences
Abstract

Lay abstractWhat is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring.

Published
2021

44. Validación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico

Author

Lee, Joo Myung, Lee, Seung Hun, Kwon, Woochan, Kim, Han Byul, Hong, David, Kim, Hyun Kuk, Cho, Sang-Geon, Shin, Doosup, Park, Ki Seong, Kim, Jahae, Moon, Jang Bae, Song, Ho-Chun, Lee, Seungrok, Ha, Dong-Heon, Jang, Jinah, Ahn, Youngkeun, Jeong, Myung Ho, Choi, Ki Hong, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, and Hong, Young Joon

Published
2024
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46. Experimental validation of coronary stenosis severity and development of ischemic myocardium

Author

Lee, Joo Myung, Lee, Seung Hun, Kwon, Woochan, Kim, Han Byul, Hong, David, Kim, Hyun Kuk, Cho, Sang-Geon, Shin, Doosup, Park, Ki Seong, Kim, Jahae, Moon, Jang Bae, Song, Ho-Chun, Lee, Seungrok, Ha, Dong-Heon, Jang, Jinah, Ahn, Youngkeun, Jeong, Myung Ho, Choi, Ki Hong, Park, Taek Kyu, Yang, Jeong Hoon, Song, Young Bin, Hahn, Joo-Yong, Choi, Seung-Hyuk, Gwon, Hyeon-Cheol, and Hong, Young Joon

Published
2024
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48. Clinical Value of Single-Projection Angiography–Derived FFR in Noninfarct-Related Artery

Author

Kwon, Woochan, Choi, Ki Hong, Lee, Seung Hun, Hong, David, Shin, Doosup, Kim, Hyun Kuk, Park, Keun Ho, Choo, Eun Ho, Kim, Chan Joon, Kim, Min Chul, Hong, Young Joon, Ahn, Sung Gyun, Doh, Joon-Hyung, Lee, Sang Yeub, Park, Sang Don, Lee, Hyun-Jong, Kang, Min Gyu, Koh, Jin-Sin, Cho, Yun-Kyeong, Nam, Chang-Wook, Joh, Hyun Sung, Kyu Park, Taek, Yang, Jeong Hoon, Song, Young Bin, Choi, Seung-Hyuk, Jeong, Myung Ho, Gwon, Hyeon-Cheol, Hahn, Joo-Yong, and Lee, Joo Myung

Published
2024
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