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467 results on '"Myerson, Saul G."'

8. Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis

Author

Kwak, Soongu, Everett, Russell J., Treibel, Thomas A., Yang, Seokhun, Hwang, Doyeon, Ko, Taehoon, Williams, Michelle C., Bing, Rong, Singh, Trisha, Joshi, Shruti, Lee, Heesun, Lee, Whal, Kim, Yong-Jin, Chin, Calvin W.L., Fukui, Miho, Al Musa, Tarique, Rigolli, Marzia, Singh, Anvesha, Tastet, Lionel, Dobson, Laura E., Wiesemann, Stephanie, Ferreira, Vanessa M., Captur, Gabriella, Lee, Sahmin, Schulz-Menger, Jeanette, Schelbert, Erik B., Clavel, Marie-Annick, Park, Sung-Ji, Rheude, Tobias, Hadamitzky, Martin, Gerber, Bernhard L., Newby, David E., Myerson, Saul G., Pibarot, Phillipe, Cavalcante, João L., McCann, Gerry P., Greenwood, John P., Moon, James C., Dweck, Marc R., and Lee, Seung-Pyo

Published
2021
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11. Myocardial scar and remodelling predict long-term mortality in severe aortic stenosis beyond 10 years.

Author

Thornton, George D, Vassiliou, Vassilios S, Musa, Tarique A, Aziminia, Nikoo, Craig, Neil, Dattani, Abhishek, Davies, Rhodri H, Captur, Gabriella, Moon, James C, Dweck, Marc R, Myerson, Saul G, Prasad, Sanjay K, McCann, Gerry P, Greenwood, John P, Singh, Anvesha, Treibel, Thomas A, and Consortium, BSCMR AS700

Subjects
AORTIC stenosis, HEART failure, MORTALITY, HEART valve prosthesis implantation, SCARS, VENTRICULAR ejection fraction, LEFT ventricular hypertrophy
Abstract

This article, published in the European Heart Journal, discusses the association between myocardial scar and long-term mortality in patients with severe aortic stenosis (AS). The study, conducted by a UK consortium, used cardiovascular magnetic resonance (CMR) imaging to detect myocardial scarring and found that it was independently associated with increased all-cause and cardiovascular mortality beyond 10 years of follow-up. The presence of scar reduced median survival by 3.5 years. The study also identified other factors, such as age, sex, type 2 diabetes mellitus, and atrial fibrillation, that were associated with mortality. The findings suggest that evaluating myocardial scar is important for assessing post-intervention risk in patients with severe AS. [Extracted from the article]

Published
2024
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15. Non-invasive cardiovascular magnetic resonance assessment of pressure recovery distance after aortic valve stenosis

Author

Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Fernandes, Joao F., Gill, Harminder, Nio, Amanda, Faraci, Alessandro, Galli, Valeria, Marlevi, David, Bissell, Malenka, Ha, Hojin, Rajani, Ronak, Mortier, Peter, Myerson, Saul G., Dyverfeldt, Petter, Ebbers, Tino, Nordsletten, David A., Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Fernandes, Joao F., Gill, Harminder, Nio, Amanda, Faraci, Alessandro, Galli, Valeria, Marlevi, David, Bissell, Malenka, Ha, Hojin, Rajani, Ronak, Mortier, Peter, Myerson, Saul G., Dyverfeldt, Petter, Ebbers, Tino, and Nordsletten, David A.

Abstract

Background Decisions in the management of aortic stenosis are based on the peak pressure drop, captured by Doppler echocardiography, whereas gold standard catheterization measurements assess the net pressure drop but are limited by associated risks. The relationship between these two measurements, peak and net pressure drop, is dictated by the pressure recovery along the ascending aorta which is mainly caused by turbulence energy dissipation. Currently, pressure recovery is considered to occur within the first 40–50 mm distally from the aortic valve, albeit there is inconsistency across interventionist centers on where/how to position the catheter to capture the net pressure drop. Methods We developed a non-invasive method to assess the pressure recovery distance based on blood flow momentum via 4D Flow cardiovascular magnetic resonance (CMR). Multi-center acquisitions included physical flow phantoms with different stenotic valve configurations to validate this method, first against reference measurements and then against turbulent energy dissipation (respectively n = 8 and n = 28 acquisitions) and to investigate the relationship between peak and net pressure drops. Finally, we explored the potential errors of cardiac catheterisation pressure recordings as a result of neglecting the pressure recovery distance in a clinical bicuspid aortic valve (BAV) cohort of n = 32 patients. Results In-vitro assessment of pressure recovery distance based on flow momentum achieved an average error of 1.8 ± 8.4 mm when compared to reference pressure sensors in the first phantom workbench. The momentum pressure recovery distance and the turbulent energy dissipation distance showed no statistical difference (mean difference of 2.8 ± 5.4 mm, R2 = 0.93) in the second phantom workbench. A linear correlation was observed between peak and net pressure drops, however, with strong dependences on the valvular morphology. Finally, in the BAV cohort the pressure recovery distance was 7

Published
2023

16. Report from the Annual Conference of the British Society of Echocardiography, November 2017, Edinburgh International Conference Centre, Edinburgh

Author

Sharma, Vishal, Stout, Martin, Pearce, Keith, Klein, Allan L., Alsharqi, Maryam, Nihoyannopoulos, Petros, Khan, Jamal Nasir, Griffiths, Timothy, Sandhu, Kully, Cabezon, Sinead, Kwok, Chun Shing, Baig, Shanat, Naneishvili, Tamara, Lee, Vetton Chee Kay, Pasricha, Arron, Robins, Emily, Kanagala, Prathap, Fatima, Tamseel, Mihai, Andreea, Butler, Robert, Duckett, Simon, Heatlie, Grant, Gu, Haotian, Chowienczyk, Phil, Arnold, Linda, Coffey, Sean, Loudon, Margaret, Wilson, Jo, Kennedy, Andrew, Myerson, Saul G., Prendergast, Bernard, Jackson, Alice M., Lennie, Vera, Luke, Peter Lee, Eggett, Christopher James, Spyridopoulos, Loakim, Irvine, Timothy Simon, Ismail, Nashwah, Macnab, Anita, Bleakley, Caroline, Eskandari, Mehdi, Aldalati, Omar, Whittaker, Almira, Huang, Marilou, Monaghan, Mark J., Turner, Thomas J., Steele, Conor, Barton, Anna, Cameron, Alan C., Sonecki, Piotr, Phang, Gyee Vuei, Voukalis, Christos, Teh, Hwee Phen, Apostolakis, Stavros, Wong, Chih, Lee, Matthew M. Y., Goodfield, Nicolas E. R., Lane, Emma, Slessor, David, Crawley, Richard, Ntoskas, Theodoros, Ahmad, Farhanda, Woodmansey, Paul, Fletcher, Andrew J., Robinson, Shaun, Rana, Bushra S., Batchelor, Liam, McAdam, Brogan, Coats, Caroline J., Mayall, Louise C., Campbell, Niall G., and Garnett, Hannah

Published
2019
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24. Myocardial Scar and Mortality in Severe Aortic Stenosis: Data From the BSCMR Valve Consortium

Author

Musa, Tarique A., Treibel, Thomas A., Vassiliou, Vassiliou S., Captur, Gabriella, Singh, Anvesha, Chin, Calvin, Dobson, Laura E., Pica, Silvia, Loudon, Margaret, Malley, Tamir, Rigolli, Marzia, Foley, James R.J., Bijsterveld, Petra, Law, Graham R., Dweck, Marc R., Myerson, Saul G., McCann, Gerry P., Prasad, Sanjay K., Moon, James C., and Greenwood, John P.

Published
2018
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28. United Kingdom standards for non-invasive cardiac imaging: recommendations from the Imaging Council of the British Cardiovascular Society

Author

Treibel, Thomas A., Kelion, Andrew, Ingram, Thomas E., Archbold, R. Andrew, Myerson, Saul G., Menezes, Leon J., Morgan-Hughes, Gareth J., Schofield, Rebecca, Keenan, Niall G., Clarke, Sarah C., Keys, Alan, Keogh, Bruce, Masani, Navroz, Ray, Simon, Westwood, Mark, Pearce, Keith, Colebourn, Claire L., Bull, Russell K., Greenwood, John Pierre, Roditi, Giles H., Lloyd, Guy, Imaging Council of the British Cardiovascular Society, British Society of Echocardiography, British Cardiovascular Society, British Society of Cardiovascular Magnetic Resonance, British Nuclear Cardiology Society, and British Society of Cardiovascular Imaging/Computed Tomography

Abstract

Heart and circulatory diseases affect more than seven million people in the UK. Non-invasive cardiac imaging is a critical element of contemporary cardiology practice. Progressive improvements in technology over the last 20 years have increased diagnostic accuracy in all modalities and led to the incorporation of non-invasive imaging into many standard cardiac clinical care pathways. Cardiac imaging tests are requested by a variety of healthcare practitioners and performed in a range of settings from the most advanced hospitals to local health centres. Imaging is used to detect the presence and consequences of cardiovascular disease, as well as to monitor the response to therapies. The previous UK national imaging strategy statement which brought together all of the non-invasive imaging modalities was published in 2010. The purpose of this document is to collate contemporary standards developed by the modality-specific professional organisations which make up the British Cardiovascular Society Imaging Council, bringing together common and essential recommendations. The development process has been inclusive and iterative. Imaging societies (representing both cardiology and radiology) reviewed and agreed on the initial structure. The final document therefore represents a position, which has been generated inclusively, presents rigorous standards, is applicable to clinical practice and deliverable. This document will be of value to a variety of healthcare professionals including imaging departments, the National Health Service or other organisations, regulatory bodies, commissioners and other purchasers of services, and service users, i.e., patients, and their relatives.

Published
2022

30. Effectiveness of exhaled nitric oxide for the prediction of non-invasive left atrial pressure in older people: a cross-sectional cohort study.

Author

Jones, Samuel Thomas, Londahl, Monica, Prothero, Anthony, Richard Hobbs, F. D., Pavord, Ian, Myerson, Saul G., Prendergast, Bernard D., and Coffey, Sean

Subjects
BLOOD pressure, ECHOCARDIOGRAPHY, HEART valve diseases, CROSS-sectional method, CARDIOVASCULAR diseases, RISK assessment, PRIMARY health care, SEX distribution, HEART atrium, DESCRIPTIVE statistics, RESPIRATION, NITRIC oxide, LEFT heart atrium, LONGITUDINAL method, ALGORITHMS, DISEASE risk factors, OLD age
Abstract

Background: During left-sided heart failure (HF), left atrial and pulmonary venous pressure increase, which may lead to pulmonary congestion. Previous cohort studies, examining participants with symptomatic HF or rheumatic heart disease, suggest a relationship between increased left atrial pressure (LAP) and fractional exhaled nitric oxide (FeNO). Aim: To examine the strength of association between FeNO and echocardiographic assessment of LAP by the E/e’ ratio, to determine if FeNO could be used to identify those with elevated LAP. Design & setting: This cross-sectional cohort study examined a subset of the OxVALVE cohort aged ≥65 years. Data collection was undertaken in primary care practices in central England. Method: Each participant underwent a focused cardiovascular history and clinical examination. Standard transthoracic echocardiographic (TTE) assessment was performed on all participants, with the E/e’ ratio calculated to obtain a validated surrogate of LAP. FeNO was measured in 227 participants. Results: FeNO was higher in males compared with females and no different in participants with asthma, chronic obstructive pulmonary disease (COPD), or those using inhaled steroids. Participants with a high E/e’ (>14) were older, with a higher proportion of females than males. There was no relationship between E/e’ and FeNO, either when measured as a continuous variable or in the group with high E/e’. Conclusion: FeNO was not found to be an accurate predictor of elevated LAP in a primary care setting. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Association of Myocardial Fibrosis and Stroke Volume by Cardiovascular Magnetic Resonance in Patients With Severe Aortic Stenosis With Outcome After Valve Replacement

Author

Thornton, George D., primary, Musa, Tarique A., additional, Rigolli, Marzia, additional, Loudon, Margaret, additional, Chin, Calvin, additional, Pica, Silvia, additional, Malley, Tamir, additional, Foley, James R. J., additional, Vassiliou, Vassilios S., additional, Davies, Rhodri H., additional, Captur, Gabriella, additional, Dobson, Laura E., additional, Moon, James C., additional, Dweck, Marc R., additional, Myerson, Saul G., additional, Prasad, Sanjay K., additional, Greenwood, John P., additional, McCann, Gerry P., additional, Singh, Anvesha, additional, and Treibel, Thomas A., additional

Published
2022
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34. A Longitudinal Study of Mitral Regurgitation Detected after Acute Myocardial Infarction

Author

Sharma, Harish, primary, Yuan, Mengshi, additional, Shakeel, Iqra, additional, Hodson, James, additional, Radhakrishnan, Ashwin, additional, Brown, Samuel, additional, May, John, additional, O’Connor, Kieran, additional, Zia, Nawal, additional, Doshi, Sagar N., additional, Hothi, Sandeep S., additional, Townend, Jonathan N., additional, Myerson, Saul G., additional, Ludman, Peter F., additional, Steeds, Richard P., additional, and Nadir, M. Adnan, additional

Published
2022
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35. The characteristics of mitral regurgitation: Data from patients admitted following acute myocardial infarction

Author

Sharma, Harish, primary, Radhakrishnan, Ashwin, additional, Nightingale, Peter, additional, Brown, Samuel, additional, May, John, additional, O'Connor, Kieran, additional, Shakeel, Iqra, additional, Zia, Nawal, additional, Doshi, Sagar N., additional, Townend, Jonathan N., additional, Myerson, Saul G., additional, Kirchhof, Paulus, additional, Ludman, Peter F., additional, Adnan Nadir, M., additional, and Steeds, Richard P., additional

Published
2021
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40. Sex differences in left ventricular remodelling, myocardial fibrosis and mortality after aortic valve replacement

Author

Singh, Anvesha, Musa, Tarique Al, Treibel, Thomas A, Vassiliou, Vassiliou S, Captur, Gabriella, Chin, Calvin, Dobson, Laura E, Pica, Silvia, Loudon, Margaret, Malley, Tamir, Rigolli, Marzia, Foley, James Robert John, Bijsterveld, Petra, Law, Graham R, Dweck, Marc Richard, Myerson, Saul G, Prasad, Sanjay K, Moon, James C, Greenwood, John P, and McCann, Gerry P

Subjects
Aged, 80 and over, Heart Valve Prosthesis Implantation, Male, Sex Characteristics, Ventricular Remodeling, Myocardium, aortic stenosis, Aortic Valve Stenosis, Kaplan-Meier Estimate, Middle Aged, Prognosis, Fibrosis, United Kingdom, AVR, Echocardiography, Valvular Heart Disease, Aortic Valve, Humans, Female, Longitudinal Studies, Postoperative Period, CMR, Aged
Abstract

Objectives : To investigate sex-differences in left ventricular remodeling and outcome in patients undergoing surgical or transcatheter aortic valve replacement (SAVR/TAVR). Methods : In this multicentre, observational, outcome study with imaging core lab analysis, patients with severe aortic stenosis (AS) listed for intervention at one of six UK centres were prospectively recruited and underwent cardiovascular magnetic resonance imaging (CMR). The primary endpoint was all-cause mortality and secondary endpoint was cardiovascular mortality. Results : 674 patients (425 male, 249 female, age 7514 years) were included: 399 SAVR, 275 TAVR. Females were older, had higher surgical risk scores and underwent TAVR more frequently (53% vs. 33.6%, p

Published
2019

47. Artificial Intelligence for Contrast-Free MRI: Scar Assessment in Myocardial Infarction Using Deep Learning-Based Virtual Native Enhancement.

Author

Zhang, Qiang, Burrage, Matthew K., Shanmuganathan, Mayooran, Gonzales, Ricardo A., Lukaschuk, Elena, Thomas, Katharine E., Mills, Rebecca, Leal Pelado, Joana, Nikolaidou, Chrysovalantou, Popescu, Iulia A., Lee, Yung P., Zhang, Xinheng, Dharmakumar, Rohan, Myerson, Saul G., Rider, Oliver, Channon, Keith M., Neubauer, Stefan, Piechnik, Stefan K., Ferreira, Vanessa M., and Oxford Acute Myocardial Infarction (OxAMI) Study

Published
2022
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48. Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis.

Author

UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Kwak, Soongu, Everett, Russell J, Treibel, Thomas A, Yang, Seokhun, Hwang, Doyeon, Ko, Taehoon, Williams, Michelle C, Bing, Rong, Singh, Trisha, Joshi, Shruti, Lee, Heesun, Lee, Whal, Kim, Yong-Jin, Chin, Calvin W L, Fukui, Miho, Al Musa, Tarique, Rigolli, Marzia, Singh, Anvesha, Tastet, Lionel, Dobson, Laura E, Wiesemann, Stephanie, Ferreira, Vanessa M, Captur, Gabriella, Lee, Sahmin, Schulz-Menger, Jeanette, Schelbert, Erik B, Clavel, Marie-Annick, Park, Sung-Ji, Rheude, Tobias, Hadamitzky, Martin, Gerber, Bernhard, Newby, David E, Myerson, Saul G, Pibarot, Phillipe, Cavalcante, João L, McCann, Gerry P, Greenwood, John P, Moon, James C, Dweck, Marc R, Lee, Seung-Pyo, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, Kwak, Soongu, Everett, Russell J, Treibel, Thomas A, Yang, Seokhun, Hwang, Doyeon, Ko, Taehoon, Williams, Michelle C, Bing, Rong, Singh, Trisha, Joshi, Shruti, Lee, Heesun, Lee, Whal, Kim, Yong-Jin, Chin, Calvin W L, Fukui, Miho, Al Musa, Tarique, Rigolli, Marzia, Singh, Anvesha, Tastet, Lionel, Dobson, Laura E, Wiesemann, Stephanie, Ferreira, Vanessa M, Captur, Gabriella, Lee, Sahmin, Schulz-Menger, Jeanette, Schelbert, Erik B, Clavel, Marie-Annick, Park, Sung-Ji, Rheude, Tobias, Hadamitzky, Martin, Gerber, Bernhard, Newby, David E, Myerson, Saul G, Pibarot, Phillipe, Cavalcante, João L, McCann, Gerry P, Greenwood, John P, Moon, James C, Dweck, Marc R, and Lee, Seung-Pyo

Abstract

Cardiovascular magnetic resonance (CMR) is increasingly used for risk stratification in aortic stenosis (AS). However, the relative prognostic power of CMR markers and their respective thresholds remains undefined. Using machine learning, the study aimed to identify prognostically important CMR markers in AS and their thresholds of mortality. Patients with severe AS undergoing AVR (n = 440, derivation; n = 359, validation cohort) were prospectively enrolled across 13 international sites (median 3.8 years' follow-up). CMR was performed shortly before surgical or transcatheter AVR. A random survival forest model was built using 29 variables (13 CMR) with post-AVR death as the outcome. There were 52 deaths in the derivation cohort and 51 deaths in the validation cohort. The 4 most predictive CMR markers were extracellular volume fraction, late gadolinium enhancement, indexed left ventricular end-diastolic volume (LVEDVi), and right ventricular ejection fraction. Across the whole cohort and in asymptomatic patients, risk-adjusted predicted mortality increased strongly once extracellular volume fraction exceeded 27%, while late gadolinium enhancement >2% showed persistent high risk. Increased mortality was also observed with both large (LVEDVi >80 mL/m) and small (LVEDVi ≤55 mL/m) ventricles, and with high (>80%) and low (≤50%) right ventricular ejection fraction. The predictability was improved when these 4 markers were added to clinical factors (3-year C-index: 0.778 vs 0.739). The prognostic thresholds and risk stratification by CMR variables were reproduced in the validation cohort. Machine learning identified myocardial fibrosis and biventricular remodeling markers as the top predictors of survival in AS and highlighted their nonlinear association with mortality. These markers may have potential in optimizing the decision of AVR.

Published
2021

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