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From cyclotron frequency ratios of HD^{+}/^{3}He^{+}, HD^{+}/T^{+}, and T^{+}/^{3}He^{+} we measure the mass difference between atoms of T and ^{3}He to be 1.995 940 8 (23)×10^{-5} u, corresponding to a Q value for tritium β decay of 18 592.071(22) eV. This enables an improved check on systematics of β decay experiments that set limits on neutrino mass. Using the HD^{+} mass calculated from the atomic masses of the proton and deuteron as given by Rau et al. [Nature 585, 43 (2020)NATUAS0028-083610.1038/s41586-020-2628-7], we also obtain improved atomic masses for the triton and helion (considered to be fundamental constants), namely, 3.015 500 716 066 (39) and 3.014 932 246 957 (38) u.

By simultaneously measuring the cyclotron frequencies of an H_{2}^{+} ion and a deuteron in a coupled magnetron orbit we have made an extended series of measurements of their cyclotron frequency ratio. From the observed changes in H_{2}^{+} mass energy we have followed the decay of three H_{2}^{+} ions to the vibrational ground state. We are able to assign some of our measured ratios to specific rovibrational levels, hence reducing uncertainty due to H_{2}^{+} rotational energy. Assuming the most probable assignment, we obtain a deuteron-to-proton mass ratio, m_{d}/m_{p}=1.999 007 501 272(9). Combined with the atomic mass of the deuteron [S. Rau et al., Nature (London) 585, 43 (2020).NATUAS0028-083610.1038/s41586-020-2628-7] we also obtain a new value for the atomic mass of the proton, m_{p}=1.007 276 466 574(10)  u.

We have measured cyclotron frequency ratios of H_{2}^{+} to D^{+} with sufficient precision to resolve the mass increase of H_{2}^{+} due to vibrational energy. Additional discrimination against excited vibrational levels was provided by increasing the rate of vibrational decay through Stark quenching. From our results we obtain a value for the deuteron-to-proton mass ratio, m_{d}/m_{p}=1.999 007 501 274(38), which has an uncertainty three times smaller than the current CODATA value.

Background: Ultrasound-guided regional anesthesia is increasingly used in the perioperative period but performance requires a mastery of regional ultrasound anatomy. We aimed to study whether the use of generative retrieval to learn ultrasound anatomy would improve long-term recall., Methods: Fourth-year medical students without prior training in ultrasound techniques were randomized into standard practice (SP) and generative retrieval (GR) groups. An initial pre-test consisted of 74 regional anesthesia ultrasound images testing common anatomic structures. During the study/learning session, GR participants were required to verbally identify an unlabeled anatomical structure within 10 seconds of the ultrasound image appearing on the screen. A labeled image of the structure was then shown to the GR participant for 5 seconds. SP participants viewed the same ultrasound images labeled with the correct anatomical structure for 15 seconds. Retention was tested at 1 week and 1 month following the study session. Participants completed a satisfaction survey after each session., Results: Forty-five medical students were enrolled with forty included in the analysis. There was no statistically significant difference in baseline scores (GR = 11.5 ± 4.9; SP = 11.2 ± 6.2; P = 0.84). There was no difference in scores at both the 1-week (SP = 54.5 ± 13.3; GR = 53.9 ± 10.5; P = 0.88) and 1-month (SP = 54.0 ± 14.5; GR = 50.7 ± 11.1; P = 0.42) time points. There was no statistically significant difference in learner satisfaction metrics between the groups., Conclusions: The use of generative retrieval practice to learn regional anesthesia ultrasound anatomy did not yield significant differences in learning and retention compared with standard learning., Competing Interests: Conflicts: The authors declare no conflicts of interest., (© 2019 Society for Education in Anesthesia.)

We have made precise measurements of the cyclotron frequency ratios H_{3}^{+}/HD^{+} and H_{3}^{+}/^{3}He^{+} and observe that different H_{3}^{+} ions result in different cyclotron frequency ratios. We interpret these differences as due to the molecular rotational energy of H_{3}^{+} changing its inertial mass. We also confirm that certain high J, K rotational levels of H_{3}^{+} have mean lifetimes exceeding several weeks. From measurements with the lightest H_{3}^{+} ion we obtain lower limits on the atomic masses of deuterium and helium-3 with respect to the proton.

By measuring the cyclotron frequency ratios of (3)He(+) to HD(+) and T(+) to HD(+), and using HD(+) as a mass reference, we obtain new atomic masses for (3)He and T. Our results are M[(3)He]=3.016 029 322 43(19)  u and M[T]=3.016 049 281 78(19)  u, where the uncertainty includes an uncertainty of 0.12 nu in the mass reference. Allowing for cancellation of common systematic errors, we find the Q value for tritium β decay to be (M[T]-M[(3)He])c(2)=18 592.01(7)  eV. This allows an improved test of systematics in measurements of tritium β decay that set limits on neutrino mass.

Human mesenchymal stem cells (hMSCs) induced towards chondrogenesis develop a pericellular matrix (PCM), rich in type VI collagen (ColVI) and proteoglycans such as decorin (DCN). Individual PCM protein functions still need to be elucidated to fully understand the mechanobiological role of this matrix. In this study we identified ColVI and DCN as important contributors in the mechanical function of the PCM and as biochemical modulators during chondrogenesis through targeted knockdown using shRNA lentiviral vectors. Gene expression, western blotting, immunofluorescence and cell deformation analysis were examined at 7, 14 and 28 days post chondrogenic induction. ColVI and DCN knockdown each affected gene expression of acan, bgn, and sox9 during chondrogenesis. ColVI was found to be of central importance in resisting applied strains, while DCN knockdown had strain dependent effects on deformation. We demonstrate that by using genetic engineering to control the biophysical microenvironment created by differentiating cells, it may be possible to guide cellular mechanotransduction.

Using precision, cryogenic, Penning-trap mass spectrometry we have measured the atomic mass difference M[;{115}In]-M[;{115}Sn] to be 497.489(10) keV/c;{2}. Combined with the energy of the 3/2;{+} first excited state of ;{115}Sn [J. Blachot, Nuclear Data Sheets 104, 967 (2005)10.1016/j.nds.2005.03.003], the Q value of the ;{115}In(9/2;{+}) --> ;{115}Sn(3/2;{+}) beta decay is determined to be 155(24) eV. This confirms the inference of Cattadori [Nucl. Phys. A 748, 333 (2005)10.1016/j.nuclphysa.2004.10.025] that this small branching-ratio beta decay has the lowest-known Q value. We also report improved values of the individual atomic masses: M[;{115}In] = 114.903 878 774(16) u and M[;{115}Sn] = 114.903 344 697(17) u.

The atomic masses of 130Te and 130Xe have been obtained by measuring cyclotron frequency ratios of pairs of triply charged ions simultaneously trapped in a Penning trap. The results, with 1 standard deviation uncertainty, are M(130Te)=129.906 222 744(16) u and M(130Xe)=129.903 509 351(15) u. From the mass difference the double-beta-decay Q value of 130Te is determined to be Qbetabeta(130Te)=2527.518(13) keV. This is a factor of 150 more precise than the result of the AME2003 [G. Audi, Nucl. Phys. A729, 337 (2003)10.1016/j.nuclphysa.2003.11.003].

Using colinear fast-beam laser spectroscopy with copropagating and counter-propagating beams we have measured the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ with the result 7230.585(6) cm{-1}. The experiment made use of a dual-wavelength, high-finesse, power build-up cavity excited by single-frequency lasers at 1319 and 1450 nm. The result will provide a precision test of ab initio relativistic many-body atomic theory at moderate Z.

By trapping pairs of ions in a Penning trap, alternating each ion between large and small cyclotron orbits, we have measured the cyclotron frequency ratios 12C2H4+/28Si+, 13C2H2+/28Si+, 28SiH3+/31P+, and 16O2+/31PH+, all to <30 ppt precision. The 16O2+/31PH+ data exhibit a bimodal distribution due to the polarizability of the Lambda-doubling components of the PH+ ground state, from which we obtain the electric dipole moment of 31PH+, 0.331(8) ea0. Combined with other atomic mass measurements we also obtain improved values for m(28Si), 27.976 926 535 0(6) u, and m(31P), 30.973 761 998 9(9) u.

The atomic mass of 136Xe has been measured by comparing cyclotron frequencies of single ions in a Penning trap. The result, with 1 standard deviation uncertainty, is M(136Xe)=135.907 214 484 (11) u. Combined with previous results for the mass of 136Ba [Audi, Wapstra, and Thibault, Nucl. Phys. A 729, 337 (2003)10.1016/j.nuclphysa.2003.11.003], this gives a Q value (M[136Xe]-M[136Ba])c(2)=2457.83(37) keV, sufficiently precise for ongoing searches for the neutrinoless double-beta decay of 136Xe.

One of the most striking predictions of Einstein's special theory of relativity is also perhaps the best known formula in all of science: E=mc(2). If this equation were found to be even slightly incorrect, the impact would be enormous--given the degree to which special relativity is woven into the theoretical fabric of modern physics and into everyday applications such as global positioning systems. Here we test this mass-energy relationship directly by combining very accurate measurements of atomic-mass difference, Delta(m), and of gamma-ray wavelengths to determine E, the nuclear binding energy, for isotopes of silicon and sulphur. Einstein's relationship is separately confirmed in two tests, which yield a combined result of 1-Delta(mc2)/E=(-1.4+/-4.4)x10(-7), indicating that it holds to a level of at least 0.00004%. To our knowledge, this is the most precise direct test of the famous equation yet described.

Using Doppler-tuned fast-beam laser spectroscopy the 1s2s 1S0-1s2p 3P1 intercombination interval in 28Si12+ has been measured to be 7230.5(2) cm(-1). The experiment made use of a single-frequency Nd:YAG (1.319 microm) laser and a high-finesse optical buildup cavity. The result provides a precision test of modern relativistic and QED atomic theory.

Background: Cancer clinicians do not receive routine training in the psychosocial aspects of patient care such as how to communicate bad news or respond to patients who have unrealistic expectations of cure. Postgraduate workshops may be an effective way to increase interpersonal skills in managing these stressful patient encounters., Methods: The authors conducted 2 half-day workshops for oncology faculty, one on breaking bad news and one on dealing with "problem situations." Participants met in a large group for didactic presentations and then small groups in which they used role-play and discussion to problem-solve difficult cases from their practices. The small groups were assisted in their work by trained physician facilitators. The workshops were evaluated by means of a follow-up satisfaction questionnaire as well as a self-efficacy measure, which was administered before and after the workshops., Results: Twenty-seven faculty and 2 oncology fellows participated in the training programs. Satisfaction questionnaires showed that the programs met the educational objectives and were considered to be useful and relevant by the participants. Self-efficacy questionnaires revealed an increase in confidence in communicating bad news and managing problem situation cases from before to after the workshop. The majority of attendees welcomed the opportunity to discuss their difficult cases with colleagues. A number resolved to implement newly learned approaches to common patient problems they encountered frequently., Conclusions: Communication skills workshops may be a useful modality to provide training to oncologists in stressful aspects of the physician-patient relationship. Further research is needed to assess whether long term benefits accrue to the participants., (Copyright 1999 American Cancer Society.)

Background: Physicians caring for cancer patients receive little formal training in difficult communications such as breaking bad news, discussing life support, and addressing patients' emotional concerns., Methods: The authors conducted a three-day workshop in communication skills for nine oncology attendings and three fellows. Topics for the workshop were selected by participants by a pre-workshop questionnaire. Small groups of four to five participants interviewed simulated patients who role-played scripts based on the selected topics. Sessions on self-awareness and one on planning for continuing the work of the group after the workshop were included., Results: Responses to pretest and posttest questionnaires showed that the workshop increased the participants' confidence in a number of communication areas and also in managing physician burnout. Process issues such as patient death and expectations for cure were also discussed., Conclusion: Interactive workshops offer a promising way of teaching communication skills and aspects of the physician-patient relationship to oncologists. Conclusions regarding outcome, however, are preliminary and tentative, and long-term results are uncertain.