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23 results on '"Myers, Jamie L."'

9. Molecular detection and ecological significance of the cyanobacterial genera geitlerinema and leptolyngbya in black band disease of corals

Author

Sekar, Raju, Myers, Jamie L., and Richardson, Laurie L.

Subjects
Cyanobacteria -- Genetic aspects, Gel electrophoresis -- Research, Biological sciences
Abstract

The cyanobacteria is isolated from black band disease into culture which confirms their presence in the BBD community by using denaturing gradient gel electrophoresis. The results confirm the presence of Geitlerinema in the BBD community and its ecological significance.

Published
2007

10. Identification of Novel Protein Expression Changes Following Cisplatin Treatment and Application to Combination Therapy

Author

Stark, Amy L., primary, Madian, Ashraf G., additional, Williams, Sawyer W., additional, Chen, Vincent, additional, Wing, Claudia, additional, Hause, Ronald J., additional, To, Lida Anita, additional, Gill, Amy L., additional, Myers, Jamie L., additional, Gorsic, Lidija K., additional, Ciaccio, Mark F., additional, White, Kevin P., additional, Jones, Richard B., additional, and Dolan, M. Eileen, additional

Published
2017
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12. Identification of Novel Protein Expression Changes Following Cisplatin Treatment and Application to Combination Therapy

Author

Stark, Amy L., Madian, Ashraf G., Williams, Sawyer W., Chen, Vincent, Wing, Claudia, Hause, Ronald J., To, Lida Anita, Gill, Amy L., Myers, Jamie L., Gorsic, Lidija K., Ciaccio, Mark F., White, Kevin P., Jones, Richard B., and Dolan, M. Eileen

Abstract

Determining the effect of chemotherapeutic treatment on changes in protein expression can provide important targets for overcoming resistance. Due to challenges in simultaneously measuring large numbers of proteins, a paucity of data exists on global changes. To overcome these challenges, we utilized microwestern arrays that allowed us to measure the abundance and modification state of hundreds of cell signaling and transcription factor proteins in cells following drug exposure. HapMap lymphoblastoid cell lines (LCLs) were exposed to cisplatin, a chemotherapeutic agent commonly used to treat testicular, head and neck, non-small cell lung, and gynecological cancers. We evaluated the expression of 259 proteins following 2, 6, and 12 h of cisplatin treatment in two LCLs with discordant sensitivity to cisplatin. Of these 259 proteins, 66 displayed significantly different protein expression changes (p< 0.05). Fifteen of these proteins were evaluated in a second pair of LCLs with discordant sensitivities to cisplatin; six demonstrated significant differences in expression. We then evaluated a subset of 63 proteins in a second set of LCLs with discordant sensitivity, and 40% of those that were significant in the first pair were also significant in the second part with concordant directionality (p< 0.05). We functionally validated one of the top proteins identified, PDK1, and demonstrated a synergistic relationship between cisplatin and a PDK1 inhibitor in multiple lung cancer lines. This study highlights the potential for identifying novel targets through an understanding of cellular changes in protein expression and modification following drug treatments.

Published
2024
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13. Protein Quantitative Trait Loci Identify Novel Candidates Modulating Cellular Response to Chemotherapy

Author

Stark, Amy L., primary, Hause, Ronald J., additional, Gorsic, Lidija K., additional, Antao, Nirav N., additional, Wong, Shan S., additional, Chung, Sophie H., additional, Gill, Daniel F., additional, Im, Hae K., additional, Myers, Jamie L., additional, White, Kevin P., additional, Jones, Richard Baker, additional, and Dolan, M. Eileen, additional

Published
2014
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14. A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469

Author

Ramírez, Jacqueline, primary, Kim, Tae Won, additional, Liu, Wanqing, additional, Myers, Jamie L., additional, Mirkov, Snezana, additional, Owzar, Kouros, additional, Watson, Dorothy, additional, Mulkey, Flora, additional, Gamazon, Eric R., additional, Stock, Wendy, additional, Undevia, Samir, additional, Innocenti, Federico, additional, and Ratain, Mark J., additional

Published
2014
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15. Linkage and association of successful aging to the 6q25 region in large Amish kindreds

Author

Edwards, Digna R. Velez, primary, Gilbert, John R., additional, Hicks, James E., additional, Myers, Jamie L., additional, Jiang, Lan, additional, Cummings, Anna C., additional, Guo, Shengru, additional, Gallins, Paul J., additional, Konidari, Ioanna, additional, Caywood, Laura, additional, Reinhart-Mercer, Lori, additional, Fuzzell, Denise, additional, Knebusch, Claire, additional, Laux, Renee, additional, Jackson, Charles E., additional, Pericak-Vance, Margaret A., additional, Haines, Jonathan L., additional, and Scott, William K., additional

Published
2012
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16. MCP1 SNPs and Pulmonary Tuberculosis in Cohorts from West Africa, the USA and Argentina: Lack of Association or Epistasis with IL12B Polymorphisms

Author

Velez Edwards, Digna R., primary, Tacconelli, Alessandra, additional, Wejse, Christian, additional, Hill, Philip C., additional, Morris, Gerard A. J., additional, Edwards, Todd L., additional, Gilbert, John R., additional, Myers, Jamie L., additional, Park, Yo Son, additional, Stryjewski, Martin E., additional, Abbate, Eduardo, additional, Estevan, Rosa, additional, Rabna, Paulo, additional, Novelli, Giuseppe, additional, Hamilton, Carol D., additional, Adegbola, Richard, additional, Østergaard, Lars, additional, Williams, Scott M., additional, Scott, William K., additional, and Sirugo, Giorgio, additional

Published
2012
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17. Correction: Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina

Author

Morris, Gerard A. J., primary, Edwards, Digna R. Velez, additional, Hill, Philip C., additional, Wejse, Christian, additional, Bisseye, Cyrille, additional, Olesen, Rikke, additional, Edwards, Todd L., additional, Gilbert, John R., additional, Myers, Jamie L., additional, Stryjewski, Martin E., additional, Abbate, Eduardo, additional, Estevan, Rosa, additional, Hamilton, Carol D., additional, Tacconelli, Alessandra, additional, Novelli, Giuseppe, additional, Brunetti, Ercole, additional, Aaby, Peter, additional, Sodemann, Morten, additional, Østergaard, Lars, additional, Adegbola, Richard, additional, Williams, Scott M., additional, Scott, William K., additional, and Sirugo, Giorgio, additional

Published
2011
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18. Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina

Author

Morris, Gerard A. J., primary, Edwards, Digna R. Velez, additional, Hill, Philip C., additional, Wejse, Christian, additional, Bisseye, Cyrille, additional, Olesen, Rikke, additional, Edwards, Todd L., additional, Gilbert, John R., additional, Myers, Jamie L., additional, Stryjewski, Martin E., additional, Abbate, Eduardo, additional, Estevan, Rosa, additional, Hamilton, Carol D., additional, Tacconelli, Alessandra, additional, Novelli, Giuseppe, additional, Brunetti, Ercole, additional, Aaby, Peter, additional, Sodemann, Morten, additional, Østergaard, Lars, additional, Adegbola, Richard, additional, Williams, Scott M., additional, Scott, William K., additional, and Sirugo, Giorgio, additional

Published
2011
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19. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans

Author

Velez, Digna Rosa, primary, Wejse, Christian, additional, Stryjewski, Martin E., additional, Abbate, Eduardo, additional, Hulme, William F., additional, Myers, Jamie L., additional, Estevan, Rosa, additional, Patillo, Sara G., additional, Olesen, Rikke, additional, Tacconelli, Alessandra, additional, Sirugo, Giorgio, additional, Gilbert, John R., additional, Hamilton, Carol D., additional, and Scott, William K., additional

Published
2009
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23. MCP1 SNPs and Pulmonary Tuberculosis in Cohorts from West Africa, the USA and Argentina: Lack of Association or Epistasis with IL12B Polymorphisms.

Author

Edwards, Digna R. Velez, Tacconelli, Alessandra, Wejse, Christian, Hill, Philip C., Morris, Gerard A. J., Edwards, Todd L., Gilbert, John R., Myers, Jamie L., Park, Yo Son, Stryjewski, Martin E., Abbate, Eduardo, Estevan, Rosa, Rabna, Paulo, Novelli, Giuseppe, Hamilton, Carol D., Adegbola, Richard, Østergaard, Lars, Williams, Scott M., Scott, William K., and Sirugo, Giorgio

Subjects
TUBERCULOSIS, MONOCYTE chemotactic factor, SINGLE nucleotide polymorphisms, MULTICULTURALISM
Abstract

The monocyte chemotactic protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of monocytes to M. tuberculosis infection sites, and previous studies have reported that genetic variants in MCP1 are associated with differential susceptibility to pulmonary tuberculosis (PTB). We examined eight MCP1 single nucleotide polymorphisms (SNPs) in a multi-ethnic, case-control design that included: 321 cases and 346 controls from Guinea-Bissau, 258 cases and 271 controls from The Gambia, 295 cases and 179 controls from the U.S. (African-Americans), and an additional set of 237 cases and 144 controls of European ancestry from the U.S. and Argentina. Two locus interactions were also examined for polymorphisms in MCP1 and interleukin 12B (IL12B), another gene implicated in PTB risk. Examination of previously associated MCP1 SNPs rs1024611 (-2581A/G), rs2857656 (-362G/C) and rs4586 (+900C/T) did not show evidence for association. One interaction between rs2857656 and IL12B SNP rs2288831 was observed among Africans but the effect was in the opposite direction in Guineans (OR = 1.90, p = 0.001) and Gambians (OR = 0.64, p = 0.024). Our data indicate that the effect of genetic variation within MCP1 is not clear cut and additional studies will be needed to elucidate its role in TB susceptibility. [ABSTRACT FROM AUTHOR]

Published
2012
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