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Your search keyword '"Mycotrienin I"' showing total 6 results
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6 results on '"Mycotrienin I"'

1. Total Synthesis of (+)-Mycotrienol and (+)-Mycotrienin I: Application of Asymmetric Crotylsilane Bond Constructions

Author

Craig E. Masse, James S. Panek, Michael Yang, and and Jason Solomon

Subjects
Crotylsilane, Coupling (electronics), Colloid and Surface Chemistry, Chemistry, Stereochemistry, Protein subunit, Mycotrienin I, Enantioselective synthesis, Total synthesis, Ansamycin Antibiotics, General Chemistry, Biochemistry, Catalysis
Abstract

A highly convergent asymmetric synthesis of the ansamycin antibiotics (+)-mycotrienin I (1c) and (+)-mycotrienol (1d) has been achieved through the synthesis and coupling of the C9−C16 subunit 3b a...

Published
1998
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2. Studies directed toward the synthesis of (+)-mycotrienin I. Asymmetric synthesis of the C9N21 aromatic synthon

Author

James S. Panek, Michael Yang, and Jason S. Solomon

Subjects
chemistry.chemical_compound, chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Synthon, Mycotrienin I, Enantioselective synthesis, Convergent synthesis, Alkylation, Biochemistry, Combinatorial chemistry, Dithiane
Abstract

The asymmetric synthesis of the C9N21 fragment of (+)-mycotrienin I is described employing chiral allylsilane bond construction methodology for the installation of the C12C13 absolute stereochemical relationships. In this convergent synthesis the construction of the C9C16 and C17N21 aromatic synthon subunits and their coupling through a lithio dithiane alkylation strategy are detailed.

Published
1995
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