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3. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

Author

Fukuhara, Hideo, primary, Yumoto, Kohei, additional, Sako, Miyuki, additional, Kajikawa, Mizuho, additional, Ose, Toyoyuki, additional, Kawamura, Mihiro, additional, Yoda, Mei, additional, Chen, Surui, additional, Ito, Yuri, additional, Takeda, Shin, additional, Mwaba, Mwila Hilton, additional, Wang, Jiaqi, additional, Hashiguchi, Takao, additional, Kamishikiryo, Jun, additional, Maita, Nobuo, additional, Kitatsuji, Chihiro, additional, Takeda, Makoto, additional, Kuroki, Kimiko, additional, and Maenaka, Katsumi, additional

Published
2024
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4. Author response: Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

Author

Fukuhara, Hideo, primary, Yumoto, Kohei, additional, Sako, Miyuki, additional, Kajikawa, Mizuho, additional, Ose, Toyoyuki, additional, Kawamura, Mihiro, additional, Yoda, Mei, additional, Chen, Surui, additional, Ito, Yuri, additional, Takeda, Shin, additional, Mwaba, Mwila Hilton, additional, Wang, Jiaqi, additional, Hashiguchi, Takao, additional, Kamishikiryo, Jun, additional, Maita, Nobuo, additional, Kitatsuji, Chihiro, additional, Takeda, Makoto, additional, Kuroki, Kimiko, additional, and Maenaka, Katsumi, additional

Published
2024
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5. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination

Author

Fukuhara, Hideo, primary, Yumoto, Kohei, additional, Sako, Miyuki, additional, Kajikawa, Mizuho, additional, Ose, Toyoyuki, additional, Kawamura, Mihiro, additional, Yoda, Mei, additional, Chen, Surui, additional, Ito, Yuri, additional, Takeda, Shin, additional, Mwaba, Mwila Hilton, additional, Wang, Jiaqi, additional, Hashiguchi, Takao, additional, Kamishikiryo, Jun, additional, Maita, Nobuo, additional, Kitatsuji, Chihiro, additional, Takeda, Makoto, additional, Kuroki, Kimiko, additional, and Maenaka, Katsumi, additional

Published
2023
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6. ヘマグルチニンタンパク質を標的としたモノクローナル抗体による犬ジステンパーウイルスの感染阻害 [全文の要約]

Author

MWABA, MWILA HILTON, 前仲, 勝実, 小川, 美香子, 黒木, 喜美子, 高倉, 栄男, and 福原, 秀雄

Abstract

この博士論文全文の閲覧方法については、以下のサイトをご参照ください。【担当：薬学部図書室】, https://www.lib.hokudai.ac.jp/dissertations/copy-guides/, (主査) 教授 前仲 勝実, 教授 小川 美香子, 准教授 黒木 喜美子, 講師 高倉 栄男, 特任助教 福原 秀雄, 生命科学院（生命科学専攻）

Published
2019

8. Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species

Author

Fukuhara, Hideo, primary, Ito, Yuri, additional, Sako, Miyuki, additional, Kajikawa, Mizuho, additional, Yoshida, Koki, additional, Seki, Fumio, additional, Mwaba, Mwila Hilton, additional, Hashiguchi, Takao, additional, Higashibata, Masa-aki, additional, Ose, Toyoyuki, additional, Kuroki, Kimiko, additional, Takeda, Makoto, additional, and Maenaka, Katsumi, additional

Published
2019
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9. Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species

Author

Fukuhara, Hideo, Ito, Yuri, Sako, Miyuki, Kajikawa, Mizuho, Yoshida, Koki, Seki, Fumio, Mwaba, Mwila Hilton, Hashiguchi, Takao, Higashibata, Masa-aki, Ose, Toyoyuki, Kuroki, Kimiko, Takeda, Makoto, Maenaka, Katsumi, Fukuhara, Hideo, Ito, Yuri, Sako, Miyuki, Kajikawa, Mizuho, Yoshida, Koki, Seki, Fumio, Mwaba, Mwila Hilton, Hashiguchi, Takao, Higashibata, Masa-aki, Ose, Toyoyuki, Kuroki, Kimiko, Takeda, Makoto, and Maenaka, Katsumi

Abstract

Measles virus (MV) and canine distemper virus (CDV) are highly contagious and deadly, forming part of the morbillivirus genus. The receptor recognition by morbillivirus hemagglutinin (H) is important for determining tissue tropism and host range. Recent reports largely urge caution as regards to the potential expansion of host specificities of morbilliviruses. Nonetheless, the receptor-binding potential in different species of morbillivirus H proteins is largely unknown. Herein, we show that the CDV-H protein binds to the dog signaling lymphocyte activation molecule (SLAM), but not to the human, tamarin, or mouse SLAM. In contrast, MV-H can bind to human, tamarin and dog SLAM, but not to that of mice. Notably, MV binding to dog SLAM showed a lower affinity and faster kinetics than that of human SLAM, and MV exhibits a similar entry activity in dog SLAM- and human SLAM-expressing Vero cells. The mutagenesis study using a fusion assay, based on the MV-H-SLAM complex structure, revealed differences in tolerance for the receptor specificity between MV-H and CDV-H. These results provide insights into H-SLAM specificity related to potential host expansion.

Published
2019

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