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22 results on '"Muzlovic, I."'

1. Molecular epidemiology of MRSA in 13 ICUs from eight European countries

Author

Hetem, D. J., Derde, L. P. G., Empel, J., Mroczkowska, A., Orczykowska-Kotyna, M., Kozińska, A., Hryniewicz, W., Goossens, H., Bonten, M. J. M., Cooper, B., Malhotra-Kumar, S., Willems, R., Gniadkowski, M., Dautzenberg, M., Annane, D., Aragão, I., Chalfine, A., Dumpis, U., Esteves, F., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G., Tomic, V., Martí, A. Torres, Stammet, P., Brun-Buisson, C., Aires, E., Antoniadou, A., Armaganidis, A., Blairon, F., Carneiro, J., Chaskou, D., Coppadoro, P., Dias, A.-P., Drinovec, I., Elia, M., Exarchou, V., Flet, A., Fournier, J., Gillet, N., Jaklič, A., Jereb, M., Kane, A., Karkali, E., Kieffer, J., Kirpach, P., Landelle, C., Landercy, F., Lawrence, C., Legrand, P., Lopes, V., Magira, E., Marco, F., Martínez, J. A., Melbārde-Kelmere, A., Misset, B., Monte, R., Moreno, E., Nguyen, J. C., Novak, M., Orazi, D., Papadomichelakis, E., Papaparaskevas, J., Paris, M., Pavleas, J., Pimenta, F., Piñer, R., Radouan, A., Ramunno, M.-G., Reis, M., Rinaldi, I., Ronco, E., Jose, A. San, Seme, K., Skiada, A., Trapassi, S., Tronci, M., Verachten, M., Vila, J., Vrankar, K., Winkler, M., Zagavierou, S., Hopman, M., Leus, F., Schotsman, J., and Zwerver, J.

Published
2016
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2. Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008–11

Author

Papagiannitsis, C. C., Izdebski, R., Baraniak, A., Fiett, J., Herda, M., Hrabák, J., Derde, L. P. G., Bonten, M. J. M., Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-Buisson, C., Gniadkowski, M., Grabowska, A., Nikonorow, E., Dautzenberg, M. J., Adler, A., Kazma, M., Navon-Venezia, S., Malhotra-Kumar, S., Lammens, C., Legrand, P., Annane, D., Chalfine, A., Giamarellou, H., Petrikkos, G. L., Nardi, G., Balode, A., Dumpis, U., Stammet, P., Arag, I., Esteves, F., Muzlovic, I., Tomic, V., Mart, A. Torres, Lawrence, C., Salomon, J., Paul, M., Lerman, Y., Rossini, A., Salvia, A., Samso, J. Vidal, and Fierro, J.

Published
2015
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3. MLST reveals potentially high-risk international clones of Enterobacter cloacae

Author

Izdebski, R., Baraniak, A., Herda, M., Fiett, J., Bonten, M. J. M., Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-Buisson, C., Gniadkowski, M., Grabowska, A., Nikonorow, E., Derde, L. P. G., Dautzenberg, M. J., Adler, A., Kazma, M., Navon-Venezia, S., Malhotra-Kumar, S., Lammens, C., Dumpis, U., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G. L., Stammet, P., Salomon, J., Lawrence, C., Legrand, P., Rossini, A., Salvia, A., Samso, J. Vidal, Fierro, J., Paul, M., and Lerman, Y.

Published
2015
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5. Assessing predictive accuracy for outcomes of ventilator-associated events in an international cohort: the EUVAE study

Author

Ramirez-Estrada, S., Lagunes, L., Pena-Lopez, Y., Vahedian-Azimi, A., Nseir, S., Arvaniti, K., Bastug, A., Totorika, I., Oztoprak, N., Bouadma, L., Koulenti, D., Rello, J., Asumaninan, Gragera, B. A., Poulakou, G., Dimopoulos, G., Bozkurt, I., Muzlovic, I., Vidaur, L., Oikonomou, M., and Bassetti, M.

Subjects
Ventilator-associated events, Male, medicine.medical_specialty, Original, Atelectasis, Critical Care and Intensive Care Medicine, Hypoxemia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Anesthesiology, Intensive care, Medicine, Ventilator-associated pneumonia, Humans, 030212 general & internal medicine, Prospective Studies, Bronchitis, Diagnostic Techniques and Procedures, Aged, Surveillance, Ventilator-associated tracheobronchitis, Anti-Bacterial Agents, Female, Middle Aged, Pneumonia, Ventilator-Associated, Respiration, Artificial, business.industry, Respiration, Pneumonia, medicine.disease, Ventilator-Associated, 030228 respiratory system, Emergency medicine, Cohort, Artificial, medicine.symptom, business, Complication
Abstract

Purpose To analyze the impact on patient outcome of ventilator-associated events (VAEs) as defined by the Centers for Disease Control and Prevention (CDC) in 2008, 2013, and the correlation with ventilator-associated pneumonia (VAP) or tracheobronchitis (VAT). Methods This was a prospective, observational, multicenter, international study conducted at 13 intensive care units (ICUs); thirty consecutive adults mechanically ventilated for ≥ 48 h per site were eligible, with daily follow-up being recorded in a collaborative web database; VAEs were assessed using the 2013 CDC classification and its 2015 update. Results A total of 2856 ventilator days in 244 patients were analyzed, identifying 33 VAP and 51 VAT episodes; 30-day ICU mortality was significantly higher (42.8 vs. 19.6%, p

Published
2018

6. MLST reveals potentially high-risk international clones of Enterobacter cloacae

Author

Izdebski, R. Baraniak, A. Herda, M. Fiett, J. Bonten, M.J.M. Carmeli, Y. Goossens, H. Hryniewicz, W. Brun-buisson, C. Gniadkowski, M. Grabowska, A. Nikonorow, E. Derde, L.P.G. Dautzenberg, M.J. Adler, A. Kazma, M. Navon-venezia, S. Malhotra-kumar, S. Lammens, C. Dumpis, U. Giamarellou, H. Muzlovic, I. Nardi, G. Petrikkos, G.L. Stammet, P. Salomon, J. Lawrence, C. Legrand, P. Rossini, A. Salvia, A. Samso, J.V. Fierro, J. Paul, M. Lerman, Y. MOSAR WP2, WP3 WP5 study groups

Subjects
bacterial infections and mycoses
Abstract

Objectives: To perform the first multinational Enterobacter cloacae clonality study, using the MLST scheme newly developed in Japan. Methods: The analysis included 195 rectal carriage E. cloacae isolates resistant to expanded-spectrum cephalosporins (ESCs), collected from patients in 12 hospital units across Europe and Israel. All of the isolates were typed by PFGE and 173 isolates were subjected to MLST. ESC resistance was analysed phenotypically; genes encoding ESBLs and carbapenemases were identified by PCR and sequencing. Results: MLST distinguished 88 STs, which correlated with the PFGE data. PFGE was more discriminatory, producing 129 pulsotypes (169 patterns). Numerous STs were observed in several countries each. The most widespread were ST66, ST78, ST108 and ST114, each having at least 10 isolates from three to five countries, diversified into multiple pulsotypes, with clusters of related isolates in one or more centres. Analysis of the STs against the MLST database revealed several epidemic clonal complexes, such as those with central genotypes ST74 (including ST78) or ST114 (including ST66). ESC resistance was equally related to overexpression of the AmpC cephalosporinase and to ESBL production. Among ESBL producers some spreading subclones were identified, including specific ST66, ST78 and ST114 pulsotypes, associated with CTX-M-15 production. Several isolates produced carbapenemase VIM-1 or KPC-2. Conclusions: Together with the information available in the MLST database, our results suggest that, like Escherichia coli and Klebsiella pneumoniae, E. cloacae harbours clonal lineages of increased epidemic potential that may be associated with resistance spread. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Published
2015

7. Survey of metallo-β-lactamase-producing Enterobacteriaceae colonizing patients in European ICUs and rehabilitation units, 2008-11

Author

Papagiannitsis, C.C. Izdebski, R. Baraniak, A. Fiett, J. Herda, M. Hrabák, J. Derde, L.P.G. Bonten, M.J.M. Carmeli, Y. Goossens, H. Hryniewicz, W. Brun-Buisson, C. Gniadkowski, M. Grabowska, A. Nikonorow, E. Dautzenberg, M.J. Adler, A. Kazma, M. Navon-Venezia, S. Malhotra-Kumar, S. Lammens, C. Legrand, P. Annane, D. Chalfine, A. Joseph, S. Giamarellou, H. Petrikkos, G.L. Nardi, G. Balode, A. Dumpis, U. Stammet, P. Aragâo, I. Esteves, F. Muzlovic, I. Tomic, V. Martí, A.T. Lawrence, C. Salomon, J. Paul, M. Lerman, Y. Rossini, A. Salvia, A. Samso, J.V. Fierro, J. MOSAR WP2, WP3 WP5 study groups

Subjects
biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Objectives: The objective of this study was to perform a multinational survey of patients' colonization by metallo-β-lactamase (MBL)-producing Enterobacteriaceae, including their molecular characterization. Methods: Patients in 18 hospital units across Europe and Israel (n = 17 945) were screened between mid-2008 and mid-2011. MBL-producing isolates were typed by PFGE and MLST. MBL genes were amplified and sequenced within their integrons. Plasmids with MBL genes were analysed by nuclease S1 plus hybridization profiling, mating and transformation assays, and by PCR-based replicon typing. Results: Ninety-one patients in nine centres (six countries), including 62 patients in two Greek ICUs, carried 94 non-duplicate MBL-producing organisms. Klebsiella pneumoniae isolates from Greece dominated (n = 57) and belonged mainly to ST147, ST36 and ST383. All but one of the isolates expressed VIM-1-type MBLs. Isolates of Greek origins produced five enzymes, including new VIM-39, encoded by class 1 integrons of four types. In-e541-like elements prevailed, comprising six variants located on IncR, IncFIIK, IncR + FIIK, IncR + A/C or non-typeable plasmids. The other group were new In4873 and In4863, being the first In416-like elements identified in Greece, which were present on IncA/C or non-typeable plasmids. Isolates from other countries produced only VIM-1 and the major integron was In916, identified in 16 organisms from France, Italy and Spain. In916 was carried by four plasmid types, including IncA/C, IncFIIK and IncHI2. Other integrons included a new element, In3103, in Spain and In110 identified only in Latvia. Conclusions: This study provided fully comparable data on the occurrence and molecular characteristics of VIM-producing Enterobacteriaceae in a group of hospital units across Europe, documenting recent changes in their epidemiology. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Published
2015

8. Molecular epidemiology of MRSA in 13 ICUs from eight European countries

Author

MMB opleiding Arts microbioloog, MICU, Medische Staf Intensive Care, Infection & Immunity, Epi Infectieziekten, MMB, JC onderzoeksprogramma Infectieziekten, MMB Research line 2, Epi Infectieziekten Team 1, Datamanagement 1, Hetem, D. J., Derde, L. P G, Empel, J., Mroczkowska, A., Orczykowska-Kotyna, M., Kozińska, A., Hryniewicz, W., Goossens, H., Bonten, M. J M, Cooper, B., Malhotra-Kumar, S., Willems, R., Gniadkowski, M., Dautzenberg, M., Annane, D., Aragão, I., Chalfine, A., Dumpis, U., Esteves, F., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G., Tomic, V., Torres Martí, A., Stammet, P., Brun-Buisson, C., Aires, E., Antoniadou, A., Armaganidis, A., Blairon, F., Carneiro, J., Chaskou, D., Coppadoro, P., Dias, A. P., Drinovec, I., Elia, M., Exarchou, V., Flet, A., Fournier, J., Gillet, N., Jaklič, A., Jereb, M., Kane, A., Karkali, E., Kieffer, J., Kirpach, P., Landelle, C., Landercy, F., Lawrence, C., Legrand, P., Lopes, V., Magira, E., Marco, F., Martínez, J. A., Melbarde-Kelmere, A., Misset, B., Monte, R., Moreno, E., Nguyen, J. C., Novak, M., Orazi, D., Papadomichelakis, E., Papaparaskevas, J., Paris, M., Pavleas, J., Pimenta, F., Piñer, R., Radouan, A., Ramunno, M. G., Reis, M., Rinaldi, I., Ronco, E., San Jose, A., Seme, K., Skiada, A., Trapassi, S., Tronci, M., Verachten, M., Vila, J., Vrankar, K., Winkler, M., Zagavierou, S., Hopman, M., Leus, F., Schotsman, J., Zwerver, J., MMB opleiding Arts microbioloog, MICU, Medische Staf Intensive Care, Infection & Immunity, Epi Infectieziekten, MMB, JC onderzoeksprogramma Infectieziekten, MMB Research line 2, Epi Infectieziekten Team 1, Datamanagement 1, Hetem, D. J., Derde, L. P G, Empel, J., Mroczkowska, A., Orczykowska-Kotyna, M., Kozińska, A., Hryniewicz, W., Goossens, H., Bonten, M. J M, Cooper, B., Malhotra-Kumar, S., Willems, R., Gniadkowski, M., Dautzenberg, M., Annane, D., Aragão, I., Chalfine, A., Dumpis, U., Esteves, F., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G., Tomic, V., Torres Martí, A., Stammet, P., Brun-Buisson, C., Aires, E., Antoniadou, A., Armaganidis, A., Blairon, F., Carneiro, J., Chaskou, D., Coppadoro, P., Dias, A. P., Drinovec, I., Elia, M., Exarchou, V., Flet, A., Fournier, J., Gillet, N., Jaklič, A., Jereb, M., Kane, A., Karkali, E., Kieffer, J., Kirpach, P., Landelle, C., Landercy, F., Lawrence, C., Legrand, P., Lopes, V., Magira, E., Marco, F., Martínez, J. A., Melbarde-Kelmere, A., Misset, B., Monte, R., Moreno, E., Nguyen, J. C., Novak, M., Orazi, D., Papadomichelakis, E., Papaparaskevas, J., Paris, M., Pavleas, J., Pimenta, F., Piñer, R., Radouan, A., Ramunno, M. G., Reis, M., Rinaldi, I., Ronco, E., San Jose, A., Seme, K., Skiada, A., Trapassi, S., Tronci, M., Verachten, M., Vila, J., Vrankar, K., Winkler, M., Zagavierou, S., Hopman, M., Leus, F., Schotsman, J., and Zwerver, J.

Published
2016

9. MLST reveals potentially high-risk international clones of Enterobacter cloacae

Author

Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB, MICU, Medische Staf Intensive Care, Izdebski, R., Baraniak, A., Herda, M., Fiett, J., Bonten, M. J M, Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-buisson, C., Gniadkowski, M., Grabowska, A., Nikonorow, E., Derde, L. P G, Dautzenberg, M. J., Adler, A., Kazma, M., Navon-venezia, S., Malhotra-kumar, S., Lammens, C., Dumpis, U., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G. L., Stammet, P., Salomon, J., Lawrence, C., Legrand, P., Rossini, A., Salvia, A., Samso, J. Vidal, Fierro, J., Paul, M., Lerman, Y., Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB, MICU, Medische Staf Intensive Care, Izdebski, R., Baraniak, A., Herda, M., Fiett, J., Bonten, M. J M, Carmeli, Y., Goossens, H., Hryniewicz, W., Brun-buisson, C., Gniadkowski, M., Grabowska, A., Nikonorow, E., Derde, L. P G, Dautzenberg, M. J., Adler, A., Kazma, M., Navon-venezia, S., Malhotra-kumar, S., Lammens, C., Dumpis, U., Giamarellou, H., Muzlovic, I., Nardi, G., Petrikkos, G. L., Stammet, P., Salomon, J., Lawrence, C., Legrand, P., Rossini, A., Salvia, A., Samso, J. Vidal, Fierro, J., Paul, M., and Lerman, Y.

Published
2015

10. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study

Author

Keth, Th, Azoulay, E, Echeverria, Pm, Vincent, Jl, Collaboratorsmargarit, A, Valentini, R, Alan Javier, Z, Bevilacqua, C, Curone, M, Rabuffetti, R, Comignani, P, Torres Boden, M, Chertcoff, F, Cardonatti, G, Adén, F, Marcos, L, Dónofrio, M, Fernández, R, Lamberghini, R, Balasini, S, Teves, J, Las Heras, M, Sinner, J, Ceraso, D, Curcio, D, Aguilar, L, Weller, C, Cardonnet, L, Santa Cruz, R, Manrique, E, Bernardez, D, Iolster, T, Chiappero, G, Ramos, P, Vergara, J, Moine, I, Ilutovich, S, Jannello, G, Waschbusch, M, Rios Picaza, G, Raimondi, A, Miriam, M, Lovesio, C, Caridi, M, Leong, T, Orford, N, Reece, G, Ernest, D, Hawker, F, Tan, J, Giannellis, C, Ihle, B, Bersten, A, Mcinnes, J, Tallott, M, Mcfadyen, B, Vibert, J, Parr, M, Tran, K, Sutton, J, Webb, S, Groves, N, Cole, L, Long, D, Bass, F, Erickson, S, Lipman, J, Delzoppo, C, Thomas, J, Dobb, G, Daley, M, Roberts, B, Santamaria, J, Young, J, Festa, M, Holland, R, Mullany, D, Williams, P, Corkeron, M, Gales, M, Banerjee, A, Yung, M, Mutz, N, Hiesmayr, M, Faybik, P, Fitzgerald, R, Firlinger, F, Zasmeta, G, Zink, M, Sieber, W, Hildegard, J, Bakondy, R, Schlieber, J, Filzwieser, G, Beer, R, Joannidis, M, Schuster, R, Scherzer, W, Smolle, K, Fitzal, S, Manzoor, R, Brunain, J, D'Hondt, A, Huylenbroeck, G, Van der Schueren, M, 't Kindt, H, Slock, E, Rijckaert, D, Raemaekers, J, Bourgeois, M, Van Cotthem, I, Nackaerts, G, Gusu, D, Gadisseux, P, Vancollie, O, Lignian, H, Michel, P, Fraipont, V, Vander Stappen, M, Forêt, F, De Bels, D, Devriendt, J, Massaut, J, Biston, P, Roman, A, Lambermont, B, De Meulder, A, Frederic, V, Sottiaux, T, Ruyffelaere, P, Collin, V, Anane, S, Kleiren, P, Simon, M, Machayekhi, S, Frans, E, Leroy, G, Berghmans, T, Joseph, R, Eerens, J, Laterre, P, Lagrou, B, Rutsaert, R, Pisarek, W, Dive, A, De Waele, J, Spapen, H, Damas, P, Malbrain, M, Hidalgo, J, Baptista, M, Salgado, D, Braga, M, Avila, C, Westphal, G, Caser, E, Alves, A, Friedman, G, Luz, M, Assuncao, M, Reis, H, Gomes, A, Silva, U, Nogueira Fh, W, El Dash, S, Valiatti, J, Barbosa, A, Coelho, C, Knibel, M, Minelli, C, Caovilla, J, Teixeira, G, Hovnanian, A, Rea Neto, A, Lobo, S, Lugarinho, M, Souza, P, Ferreira, D, Duarte, P, Oliveira, M, Marques, J, Machado, R, Rehder, P, Mataloun, S, Grilo, M, Quesado, P, Moock, M, Ferreira, F, Teles, J, Silva, E, Morais, A, Bruzzi de Carvalho, F, Wanderley, M, Velasco, M, Brandão da Silva, N, Feijó, J, Souza Dantas, V, Costa Filho, R, Japiassú, A, Villela, D, Santos, C, Passos, R, Alheira Rocha, R, Silva, R, Houly, J, Aldrighi, J, Hatum, R, Suparregui Dias, F, Ferreira, L, Ferro, L, Gomez, J, Fleury, R, David, C, Resener, T, Mendes, C, Germano, A, De Marco, F, Lage, S, Salluh, J, Torelly, A, Sad, R, Oliveira, G, Lima, R, Paranhos, J, Rocha, M, Bitencourt, W, Grion, C, Forte, D, Guimarães, H, Piras, C, Stephanova, L, Lyubenov, L, Tsarianski, G, Dimov, G, Green, R, Levasseur, J, Ward, R, Lesur, O, Poirier, G, Wax, R, Wood, G, Cook, D, Marshall, J, Herridge, M, Ferguson, N, Espinoza, M, Valdés jimenez, S, Bruhn, A, Micolich, J, Fricke, G, Galvez, S, Escamilla Leon, I, Zhan, Q, Xu, Y, Zhao, Y, Zhang, L, Qin, T, Du, B, Li, M, Wang, X, Jing, Y, Zhang, Z, Xianyao, W, Li, F, Congshan, Y, Rebolledo, C, Diaz, D, Murillo Arboleda, R, Arias Antun, A, Montenegro, G, Granados, M, Dueñas, C, Perez, N, Libreros Duque, G, Coral, M, Ortiz, G, Rodriguez, D, Barsic, B, Cubrilo Turek, M, Gornik, I, Grljusic, M, Caballero lopez, A, Iraola Ferrer, M, Pavlik, P, Manak, J, Radej, J, Belohlavek, J, Sevcik, P, Blahut, L, Tyl, D, Steinbach, J, Herold, I, Zykova, I, Prchal, D, Bartosik, T, Kolarova, M, Hájek, R, Kohoutová, J, Marek, O, Hon, P, Chytra, I, Betsch, H, Fogh, B, Espersen, K, Jacobsen, K, Berezowicz, P, Andrade, C, Guerrero, F, Salgado, E, Barahona, D, Del Pozo Sanchez, H, Jibaja, M, Alansary, A, Reintam, A, Starkopf, J, Harjola, V, Tual, L, Leone, M, Serge, M, Leroy, O, Mallet, L, Marc, B, Dormoy, D, Pascal, H, Tronchon, L, Garrigues, B, Santré, C, Dupont, H, Duranteau, J, Leon, A, Henry, L, Canevet, C, Dube, L, Julien, H, Nadia, A, Francois, B, Gérard, J, Freysz, M, Remy, G, Blanloeil, Y, Squara, P, Korach, Jm, Durand, M, Gabriel, C, Eric, P, Jacobs, F, Bronchard, R, Kipnis, E, Moussa, M, Launoy, A, Guérin, C, Vanhems, P, Wynckel, A, Clair, B, Fulgencio, J, Gottwalles, Y, Krummel, T, Lepape, A, Lesieur, O, Payen, D, Hérvé, O, Farkas, J, Cougot, P, Mallédant, Y, Joannes Boyau, O, Standl, T, Sierig, U, Geiseler, J, Hopf, H, Conrad Opel, E, Hermann, C, Ventzke, M, Henneberg, T, Esposito, F, Loeser, H, Spies, C, Zuckermann Becker, H, Voegeler, S, Scherer, R, Pauer, A, Kljucar, S, Delfs, K, Blank, E, Busch, J, Wendt, K, Lessmann, J, Bach, F, Sakr, Y, Berlet, T, Kernchen, A, Quintel, M, Holst, D, Kilger, E, Holubarsch, T, Raufhake, C, Stolt, C, Lubasch, A, Meier Hellmann, A, Woebker, G, Scharnofske, C, Breyer, M, Risch, T, Manhold, C, Goethe, Jw, Meininger, D, Greive, C, Rau, J, Seibel, A, Henn beilharz, A, Wolbert, R, Scherke, T, Martin, J, Rudolph, M, Gleissner, J, Wolf, M, Schleibach, F, Jaschinski, U, Lunkeit, A, Welte, M, Bingold, T, Kogelmann, K, Fischer, F, Fischer, B, Schmid, M, Klein, M, Bechtold, A, Bodmann, K, Klasen, J, Meyrl, H, Goetz, J, Geldner, G, Helmes, T, Jensen, N, Eickmeyer, H, Lengfelder, W, Langenstein, B, Bogdanski, R, Jelen Esselborn, S, Umgelter, A, Dörr, F, Lüttje, K, Heinemeyer, D, Uhl, M, Schirle, P, Benad, H, Glaser, M, Panzer, W, Huettemann, E, Stierwaldt, R, Schappacher, M, Müller, E, Stadlmeyer, W, Fantini, M, Dummer, B, Thörner, M, Jost, V, Loerbroks, T, Glück, T, Zimmermann, R, Clement, R, Hering, R, Klinger, T, Mehl, J, Polozek, H, Rothhammer, A, Seidler, R, Lorenz, P, Mueritz, W, Lutze, M, Euler, M, Heintz, M, Winkler, M, Angstwurm, M, Krohe, K, Treu, T, Steiner, T, Locher, S, Walz, A, Zahn, P, Brandt, W, Marks, M, Henning, F, Janssens, U, Luethgens, M, Theelen, W, Sydow, M, Weber, M, Meiser, A, Deutschmann, C, Buttner, C, Jokiel, M, Bozzetti, C, Jürgen, B, Fiedler, F, Wresch, K, Kremer, A, Bleier, H, Rueckert, M, Ditter, H, Peckelsen, C, Friederich, P, Weber, K, Krueger, W, Lowack, R, Michalsen, A, Ragaller, M, Groeschel, A, Friedrich, T, Hinz, M, Christel, A, Hartwig, T, Kaisers, U, Schmitt, D, Vögeler, S, Weiss, M, Reiter, K, Schwab, T, Trieschmann, U, Kindgen milles, D, Engel, J, Sedemund adib, B, Lauterbach, M, Max, M, Volkert, T, Waydhas, C, Hien, S, Briegel, J, Guralnik, V, Zoremba, N, Riessen, R, Müllges, W, Nierhaus, A, Strauss, R, Utzolino, S, Thul, J, Abel, P, Gründling, M, Kessler, W, Scheuren, K, Vagts, D, Rensing, H, Schoch, B, Kopp, K, Gerlach, H, Corea, M, Uhrig, A, Schroeder, S, Jordan, F, Huber, T, Bittinger, M, Sofianos, E, Armaganidis, A, Routsi, C, Bitzani, M, Chalkiadaki, A, Michalopoulos, A, Mouloudi, E, Ioannidou, E, Myrianthefs, P, Koulenti, D, Karampela, I, Kyriazopoulos, G, Mandragos, K, Clouva molyvdas, P, Moraiti, A, Pneumatikos, I, Filos, K, Zakynthinos, E, Kotanidou, A, Vakalos, A, Cheng, A, Buckley, T, Gomersall, C, Kiss, K, Tamási, P, Sarkany, A, Csomos, A, Zöllei, É, Todi, S, Udwadia, F, Shah, R, Amin, P, Samavedam, S, Mathai, A, Patil, M, Jog, S, Gurjar, M, Vats, M, Varma, A, Gopal, P, Kapadia, F, Chawla, R, Iyer, S, Sahu, S, Bakshi, C, Ambike, D, Govil, D, Karipparambath, V, Chacko, J, Sathe, P, Rungta, N, Jani, C, Bhome, A, Prayag, S, Ray, S, Rajagopalan, R, Divatia, J, Da costa, R, Shyam Sunder, T, Wibowo, P, Maskoen, T, Sugiman, T, Nowruzinia, S, Lotfi, A, Mahmoodpoor, A, Donnelly, M, Breen, D, Ng, S, Bates, J, Sprung, C, Lev, A, Kishinevsky, E, Cohen, J, Sofer, S, Vesconi, S, Greco, S, Borelli, M, Cecilia, P, Sapuppo, M, Lazzero, A, Mangani, V, Petrucci, N, Minerva, M, Rummo, G, De blasio, E, Marzorati, S, Rosi, R, Giarratano, A, Margarit, O, Guberti, A, Scolz, S, Stelian, E, Emmi, V, Caspani, M, Rosano, A, Abbruzzese, C, Colonna, S, Ceriani, R, De Blasi, R, Panella, L, Borrelli, F, Lorella, P, Ruatti, H, Munch, C, Sorbara, C, Fiore, G, Chieregato, A, Conti, V, Guadagnucci, A, Pizzamiglio, M, Locicero, Mt, Marri, I, Sicignano, A, Conte, V, Oggioni, R, De Gasperi, A, De negri, P, Santagostino, G, Roberto, F, Marino, G, Castiglione, G, Sforza, D, Camillo, S, Giuseppe, N, Bassetti, Matteo, Napoli, D, Ferraro, F, Clementi, S, Di Filippo, A, Cotogni, P, Ranieri, Mv, Antonelli, M, Martinelli, L, Gianesello, L, Gullo, A, Morelli, A, Biancofiore, G, DELLA ROCCA, Giorgio, Hashimoto, S, Onodera, M, Kobayashi, A, Shinozuka, T, Imanaka, H, Ikeda, T, Yaguchi, A, Misane, I, Piebalga, A, Moughaghab, A, Pilvinis, V, Vosylius, S, Balciunas, M, Kekstas, G, Margaret, H, Klop, M, Grozdanovski, K, Eftimova, B, Wafa, S, Lim, C, Mat nor, M, Tai, L, Syed Mohd Tahir, S, Idris, N, Tan, C, Borg, M, Manzo, E, Gutierrez Morales, H, Miguel, P, Villagomez, A, Bassols, A, Aguirre, G, Cerón, U, Lopez ramos, J, Monjardín, J, Bermudez Aceves, E, Gonzalez Salazar, F, Rodriguez Gonzalez, D, Poblano Morales, M, Ramirez, F, Cetina, M, Navarro, J, Villagomez Ortiz, A, Sanchez, V, Chavarria, U, Fernandez Ponce, O, Serna secundino, H, Leonardo, O, Diego Manuel, R, Mijangos, J, Vazquez de Anda, G, Martin, E, Gutierrez, P, López Islas, I, Soberanes, L, Pejakov, L, Sbihi, A, Ouahid, B, Naoufel, M, De Pont, A, Rosseel, P, Ten Cate, J, Van Berkel, G, Corsten, S, Bakker, J, Vogelaar, J, Blom, H, Kieft, H, Kuiper, M, Gille, A, Pickkers, P, Vet, J, Ammann, J, Den Boer, S, Wesselink, R, Speelberg, B, Pham, C, Rodgers, M, Bergmans, D, Groeneveld, J, Mcarthur, C, Parke, R, Mehrtens, J, Celi, L, Freebairn, R, Rankin, N, Heffernan, C, Mchugh, G, Beca, J, Van haren, F, Barry, B, Kalkoff, M, Loevstad, R, Klepstad, P, Erno, P, Junker, A, Naqvi, S, Javed, I, Sinclair, J, Rivera, R, Chavez, C, Donayre Taber, Z, Quispe Sierra, R, Muñoz, J, Galvez Ruiz, J, Fang Li, J, Candiotti Herrera, M, Arroyo, A, Becerra, R, Meza, J, Mayorga, M, Garba, P, Kot, J, Gaszynski, T, Piechota, M, Renata, S, Müller, P, Stepinska, J, Jacek, K, Cieniawa, T, Mikstacki, A, Tamowicz, B, Bartkowska Sniatkowska, A, Karpel, E, Kusza, K, Smuszkiewicz, P, Mikaszewska Sokolewicz, M, Goraj, R, Kubler, A, Bártolo, A, Castelo Branco Sousa, M, Esteves, F, Martins, A, João, Hs, Oliveira, T, Ponce, P, Mourão, L, Febra, C, Carmo, E, Lopes, V, Póvoa, P, Rezende, A, Costa, H, Moreira, P, Pádua, F, Leite, A, Almeida, E, Alves, M, Sousa, A, Telo, L, João, S, Dias, C, Paiva, J, Ribeiro, R, Amaro, P, Carneiro, A, Moreno, R, Matos, R, Afonso, S, Bouw, M, França, C, Ibrahim, A, Tabacaru, R, Ionita, V, Tulbure, D, Filipescu, D, Pascanu, S, Grigoras, I, Copotoiu, S, Popov, D, Lebedev, E, Olga, I, Yaroshetskiy, A, Lugovkina, T, Dmitry, B, Malinin, O, Lekmanov, A, Abulmagd, M, Arabi, Y, Alhashemi, J, Ali, A, Maghrabi, K, Debek, A, Malik, M, Jankovic, R, Palibrk, I, Maravic stojkovic, V, Malenkovic, V, Surbatovic, M, Bumbasirevic, V, Lim, N, Loh, T, Tan, H, Sekeresova, H, Koutun, J, Firment, J, Malik, P, Trenkler, S, Muzlovic, I, Kosec, L, Ozek, B, Kasnik, D, Tomic, V, Knafelj, R, Svigelj, V, Du Plessis, H, Raine, R, Bhagwanjee, S, Richards, G, Goosen, J, De Jager, J, Schleicher, G, Rubio, O, Mañez, R, Burgueño Campiñez, M, Alvarez, M, Jorda, R, Naveira Abeigón, E, Monedero, P, Alemparte Pardavila, E, Garcia del Valle, S, Perez Calvo, C, Palomar, M, Caballero Zirena, A, Arribas, M, Bustamante Munguira, E, Ruiz, J, Blanco Vicente, A, Zavala, E, Valencia, M, Blesa Malpica, A, Martinez Sagasti, F, Nieto, M, Aguilar, G, Martinon Torres, F, Lorente, C, Insausti, J, Vegas Pinto, R, Santos, I, Escriba, A, Olaechea, P, Muñoz, E, Antón Caraballo, E, Galdos Anuncibay, P, Lopez Camps, V, Esteban Reboll, F, Estella, A, Bocero, L, Ibañez, A, Yagüe, G, Pueyo, L, María Jesús, L, Iglesias Fraile, L, Silva, J, Garro, P, Palma, L, Ramos gómez, L, Rovira, A, Martin Delgado, M, Monton Dito, J, Garcia, F, Latour Perez, J, Albaya, A, Bustinza, A, Sole violán, J, Ugarte Peña, P, Yuste, I, De Rojas Román, J, Vallés, J, Esteban, E, Quintana Tort Martorell, E, Moreno, M, López Ciudad, V, Manzano Ramirez, A, Sánchez Olmedo, J, Borges, M, Amador Amerigo, J, Guerrero Gomez, F, Montejo González, J, Sirvent, J, Pujol, I, Mesalles Sanjuan, E, Barcenilla Gaite, F, Serrano, N, Cerdá, E, Lesmes Serrano, A, Garcia Fuentes, C, Macias Pingarrón, J, Espinosa, E, Sanchez Garcia, M, Felices, F, de la Torre Prados, M, Maria Jesus, H, Luis, V, Jara, R, Briones Lopez, M, Posada, P, Galvan, B, Mariscal, F, Rello, J, Gil, B, Sierra, R, Rico Feijoo, J, Izura, J, González, J, Soto Ibáñez, J, Agabani, H, Petersen, P, Johansson, L, Blomqvist, H, Peterzén, B, Wyon, N, Lindström, I, Paulsson, A, Agvald Ohman, C, Petersson, J, Friberg, H, Einar, V, Hammarskjöld, F, Schindele, M, Arvidsson, S, Sellgren, S, Hulting, J, Häggqvist, J, Rudenstam, J, Lind, D, Kokinsky, E, Owall, A, Jacobson, S, Stiernstrom, H, Nydahl, A, Eggimann, P, Stocker, R, Loderer, G, Loetscher, R, Heer, K, Zender, H, Cottini, S, Pagnamenta, A, Eich, G, Felleiter, P, Marco, M, Pugin, J, Shu Hui, W, Hsieh, K, Toomtong, P, Khwannimit, B, Kietdumrongwong, P, Khaldi, A, Messadi, A, Labbene, I, Frikha, N, Atalan, K, Ates, C, Kahveci, A, Ozgencil, E, Kizilkaya, M, Bosnak, M, Bodur, H, Akan, M, Guven, M, Turkoglu, M, Topeli, A, Togal, T, Uzel, N, Akinci, I, Cakar, N, Tugrul, S, Demirkiran, O, Adanir, T, Dogruer, K, Turkmen, A, Guven, H, Ulger, F, Kocak, S, Nalapko, Y, Rady, S, Alsabbah, A, Elahi, N, Al rahma, H, Rahman, M, Kashef, S, Cuthbertson, B, Gunning, K, Myint, Y, Bewley, J, Burnstein, R, Haji Michael, P, Wrathall, D, Folan, L, Nesbitt, I, Ratnaparkhi, A, Pambakian, S, Booth, M, Watters, M, Sherry, T, Buehner, U, Barrera Groba, C, Bothma, P, George, N, Frater, J, Hollos, L, Mclellan, S, Hunter, J, Garrioch, M, O'Keeffe, N, Divekar, N, Eggert, S, Smith, S, Vincent, A, Withington, P, Macmillan, C, Webster, R, Vuylsteke, A, Appadu, B, Barrera groba, C, Mcquillan, P, Blunt, M, Parekh, N, William, D, Jones, C, Krige, A, Schuster Bruce, M, Boyden, J, Boulanger, C, Swann, D, Walker, J, Wigmore, T, Law, R, Baldwin, F, Muench, C, Robinson, S, Crerar Gilbert, A, Rhodes, A, Mahambrey, T, Cameron, L, Thornton, J, Stotz, M, Russell, M, Longmate, A, Kitson, R, Browne, B, Thorniley, A, Gonzalez, I, Swart, M, Singer, M, Gautam, N, Prasad, V, Watson, D, Szakmany, T, Cardy, J, Binning, A, Loveland, R, Gannon, J, Martinelli, G, Nightingale, P, Howes, J, Steingrub, J, Ammons, L, Fisher, M, Gandhi, N, Martin, G, Deutschman, C, Dean, N, Michetti, C, Belzberg, H, Hutchinson, K, Van der kloot, T, Afessa, B, Kaufman, D, Iqbal, J, Ost, D, Afifi, S, West, M, Wunderink, R, Stein, S, Hagg, D, Jimenez, E, Blosser, S, Chhangani, S, Kleinpell, R, Reich, H, Fields, E, Willms, D, Castellanos Mateus, P, Melnik, L, Oud, L, Chi, E, Halfon, R, Badr, A, Restrepo, M, Pohlman, A, Branson, R, Simpson, S, Kett, D, Jacobs, T, Park, P, Wahl, W, Patricia, C, Hammersley, J, Papadimos, T, Sawyer, R, Freire, A, Rodriguez, W, Ryan, A, Margolis, B, Groth, M, Escanda, H, Baraibar, J, Paciel, D, Bagnulo, H, Hitta, F, Nadales, P, Albornoz, H, Salmen, Z, Pacheco, C, Bui, T, Potie, F, and Nguyen Huu, C.

Published
2011

11. Routine surface disinfection in health care facilities: should we do it?

Author

Allerberger, F., Ayliffe, G., Bassetti, M., Braveny, I., Bucher, A., Damani, N., Daschner, F., Dettenkofer, M., Ezpeleta, C., Gastmeier, P., Geffers, C., Giamarellou, H., Goldman, D., Grzesiowski, P., Gubina, M., Haanen, P.E., Haydouchka, I., Hubner, J., Kalenic, S., Knippenberg-Gordebeke, G. van, Kranenburg, A.M., Krcmery, V., Kropec, A., Kruger, W.D., Lemmen, S., Mayhall, C.G., Meester, M., Mehtar, S., Munzinger, J., Muzlovic, I., Ojajarvi, J., Ruden, H., Scott, G., Shah, P.M., Tambic-Andraszevic, A., Unertl, K., Voss, A., Weist, K., Allerberger, F., Ayliffe, G., Bassetti, M., Braveny, I., Bucher, A., Damani, N., Daschner, F., Dettenkofer, M., Ezpeleta, C., Gastmeier, P., Geffers, C., Giamarellou, H., Goldman, D., Grzesiowski, P., Gubina, M., Haanen, P.E., Haydouchka, I., Hubner, J., Kalenic, S., Knippenberg-Gordebeke, G. van, Kranenburg, A.M., Krcmery, V., Kropec, A., Kruger, W.D., Lemmen, S., Mayhall, C.G., Meester, M., Mehtar, S., Munzinger, J., Muzlovic, I., Ojajarvi, J., Ruden, H., Scott, G., Shah, P.M., Tambic-Andraszevic, A., Unertl, K., Voss, A., and Weist, K.

Abstract

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Published
2002

13. Orotracheal tube as a risk factor for lower respiratory tract infection: preliminary data from a randomised trial.

Author

Muzlovic I, Perme J, and Stubljar D

Subjects
Aged, Equipment Design, Female, Humans, Male, Prospective Studies, Respiratory System, Risk Factors, Intensive Care Units statistics & numerical data, Intubation, Intratracheal adverse effects, Pneumonia, Ventilator-Associated epidemiology, Pneumonia, Ventilator-Associated prevention & control
Abstract

Purpose: The aim of the study was to investigate whether polyurethane (PU) endotracheal tubes, continuous measurements of cuff pressure and aspiration of the subglottic space as a bundle of parameters could reduce patients' risk for developing ventilator associated pneumonia (VAP)., Methods: Two groups of patients that differed only in terms of endotracheal tubes and intubation intervention were compared. Group A was ventilated using PU tubes a with conical cuff; they also had continuous cuff pressure measurement and continuous subglottic aspiration. Group B was ventilated using PVC tubes with a cylindrical cuff; the patients underwent intermittent cuff pressure measurement and intermittent subglottic aspiration., Results: Seven patients in group A (13.2%) and 18 in group B (36.0%) out of 103 were diagnosed with VAP. VAP patients were in general older, stayed longer in the ICU and were ventilated significantly longer compared with the patients with no VAP. Eight more patients in group B died compared with group A. Moreover, subjects in group A survived longer. Patient age, hours on mechanical ventilation, and days on an ICU were all positively associated with the occurrence of VAP., Conclusions: Prevention parameters in ventilation (PU cuff, conical cuff, continuous subglottic drainage and continuous cuff pressure measurement) could prevent the incidence of VAP in ICU patients.

Published
2018
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14. CD64 index on neutrophils can diagnose sepsis and predict 30-day survival in subjects after ventilator-associated pneumonia.

Author

Muzlovic I, Ihan A, and Stubljar D

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Pilot Projects, ROC Curve, Survival Analysis, Biomarkers analysis, Neutrophils chemistry, Pneumonia, Ventilator-Associated complications, Receptors, IgG analysis, Sepsis mortality, Sepsis pathology
Abstract

Introduction: Sepsis associated with ventilator-associated pneumonia (VAP) causes mortality in intensive care unit (ICU) patients. The time of diagnosis is crucial, and microbiological cultures take time. In this study, the diagnostic accuracy of CD64 index to predict VAP-induced sepsis and survival time in subjects requiring mechanical ventilation were evaluated and compared to conventional biomarkers and culturing methods., Methodology: A total of 32 subjects with VAP were included. Sepsis after VAP was diagnosed in 25 (78.1%) patients according to clinical signs, radiographic examination, and samples of blood and trachea taken for culturing. Simultaneously with cultures, CD64 index on neutrophils, C-reactive protein (CRP), procalcitonin (PCT), and count of leucocytes and neutrophils were determined., Results: Biomarker values were evaluated in both groups of subjects (with and without sepsis after VAP). The values of CD64 index and CRP were significantly higher in the sepsis group. Receiver operating characteristic (ROC) curve analysis revealed an area under curve (AUC) of 0.929 for CD64 index in differentiating subjects with VAP-induced sepsis from those without sepsis. The biomarkers CRP and PCT showed comparable results (AUC of 0.869 and 0.909, respectively). Blood cultures were positive in 12 subjects, endotracheal aspirate in 19. CD64 index and isolation of pathogen with positive blood cultures or from endotracheal aspirate (positive in 24 cases) could predict survival time before application of more targeted antibiotic therapy., Conclusions: CD64 index may be used as a useful diagnostic tool to recognize VAP-induced sepsis; moreover, accompanied with an identified pathogen, can predict survival for ICU patients.

Published
2016
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15. Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial.

Author

Derde LPG, Cooper BS, Goossens H, Malhotra-Kumar S, Willems RJL, Gniadkowski M, Hryniewicz W, Empel J, Dautzenberg MJD, Annane D, Aragão I, Chalfine A, Dumpis U, Esteves F, Giamarellou H, Muzlovic I, Nardi G, Petrikkos GL, Tomic V, Martí AT, Stammet P, Brun-Buisson C, and Bonten MJM

Subjects
Aged, Bacterial Infections diagnosis, Bacterial Infections transmission, Cross Infection transmission, Enterobacteriaceae isolation & purification, Enterococcus isolation & purification, Female, Hand Disinfection methods, Humans, Incidence, Infection Control methods, Male, Middle Aged, Staphylococcus aureus isolation & purification, Treatment Outcome, Bacterial Infections prevention & control, Carrier State diagnosis, Chlorhexidine therapeutic use, Cross Infection prevention & control, Disease Transmission, Infectious prevention & control, Disinfectants therapeutic use, Intensive Care Units
Abstract

Background: Intensive care units (ICUs) are high-risk areas for transmission of antimicrobial-resistant bacteria, but no controlled study has tested the effect of rapid screening and isolation of carriers on transmission in settings with best-standard precautions. We assessed interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in European ICUs., Methods: We did this study in three phases at 13 ICUs. After a 6 month baseline period (phase 1), we did an interrupted time series study of universal chlorhexidine body-washing combined with hand hygiene improvement for 6 months (phase 2), followed by a 12-15 month cluster randomised trial (phase 3). ICUs were randomly assigned by computer generated randomisation schedule to either conventional screening (chromogenic screening for meticillin-resistant Staphylococcus aureus [MRSA] and vancomycin-resistant enterococci [VRE]) or rapid screening (PCR testing for MRSA and VRE and chromogenic screening for highly resistant Enterobacteriaceae [HRE]); with contact precautions for identified carriers. The primary outcome was acquisition of resistant bacteria per 100 patient-days at risk, for which we calculated step changes and changes in trends after the introduction of each intervention. We assessed acquisition by microbiological surveillance and analysed it with a multilevel Poisson segmented regression model. We compared screening groups with a likelihood ratio test that combined step changes and changes to trend. This study is registered with ClinicalTrials.gov, number NCT00976638., Findings: Seven ICUs were assigned to rapid screening and six to conventional screening. Mean hand hygiene compliance improved from 52% in phase 1 to 69% in phase 2, and 77% in phase 3. Median proportions of patients receiving chlorhexidine body-washing increased from 0% to 100% at the start of phase 2. For trends in acquisition of antimicrobial-resistant bacteria, weekly incidence rate ratio (IRR) was 0·976 (0·954-0·999) for phase 2 and 1·015 (0·998-1·032) for phase 3. For step changes, weekly IRR was 0·955 (0·676-1·348) for phase 2 and 0·634 (0·349-1·153) for phase 3. The decrease in trend in phase 2 was largely caused by changes in acquisition of MRSA (weekly IRR 0·925, 95% CI 0·890-0·962). Acquisition was lower in the conventional screening group than in the rapid screening group, but did not differ significantly (p=0·06)., Interpretation: Improved hand hygiene plus unit-wide chlorhexidine body-washing reduced acquisition of antimicrobial-resistant bacteria, particularly MRSA. In the context of a sustained high level of compliance to hand hygiene and chlorhexidine bathings, screening and isolation of carriers do not reduce acquisition rates of multidrug-resistant bacteria, whether or not screening is done with rapid testing or conventional testing., Funding: European Commission., (Copyright © 2014 Derde et al. Open Access article distributed under the terms of CC BY-NC-SA. Published by Elsevier Ltd. All rights reserved.)

Published
2014
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16. Severe human granulocytic anaplasmosis transmitted by blood transfusion.

Author

Jereb M, Pecaver B, Tomazic J, Muzlovic I, Avsic-Zupanc T, Premru-Srsen T, Levicnik-Stezinar S, Karner P, and Strle F

Subjects
Adult, Anaplasma phagocytophilum genetics, Anaplasmosis blood, Anaplasmosis drug therapy, Animals, Anti-Bacterial Agents therapeutic use, Female, Granulocytes, Humans, Pregnancy, Anaplasma phagocytophilum isolation & purification, Anaplasmosis microbiology, Anaplasmosis transmission, Blood Donors, Pregnancy Complications therapy, Transfusion Reaction
Abstract

A 36-year-old woman acquired severe human granulocytic anaplasmosis after blood transfusion following a cesarean section. Although intensive treatment with mechanical ventilation was needed, the patient had an excellent recovery. Disease caused by Anaplasma phagocytophilum infection was confirmed in 1 blood donor and in the transfusion recipient.

Published
2012
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17. Severe tick-borne encephalitis in Slovenia in the years 2001-2005: time for a mass vaccination campaign?

Author

Jereb M, Karner P, Muzlovic I, and Jurca T

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Viral blood, Cross-Sectional Studies, Encephalitis, Tick-Borne immunology, Female, Humans, Immunoglobulin G blood, Male, Middle Aged, Retrospective Studies, Risk Factors, Slovenia, Viral Vaccines immunology, Encephalitis Viruses, Tick-Borne immunology, Encephalitis, Tick-Borne epidemiology, Encephalitis, Tick-Borne prevention & control, Mass Vaccination, Viral Vaccines administration & dosage
Abstract

The aim of this retrospective study was to assess some clinical, epidemiological and laboratory parameters of severe tick-borne encephalitis in Slovenia in the last five years, to compare them with published data, and to estimate need for providing a policy of active immunization. Thirty-three adult patients with a severe course of the disease, admitted to the intensive care unit of the Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia during a five year period, participated. All the patients had specific serum IgM antibodies against tick-borne encephalitis virus at admissions and IgG antibodies were present in 29 out of 33 patients. Twenty-two patients were admitted because of severe consciousness disturbances, nine suffered from spinal nerve paralysis, in two patients cranial nerve paralysis was observed, and one suffered from generalized tonic-clonic seizures. Ten patients were mechanically ventilated and three died. Leukocytosis in peripheral veins was found in twenty-one patients and nine had a C-reactive protein serum concentration over 50 mg/l. Nineteen patients had a cerebrospinal fluid leukocyte count exceeding 100 x 10(6)/l and a cerebrospinal fluid protein concentration was over the cut-off value of 0.45 g/l in majority. The findings of the present study confirmed some previous reports about clinical, epidemiological and laboratory characteristics of patients with severe tick-borne encephalitis. We have found that tick-borne encephalitis in Slovenia has a relatively low fatality rate. However, the severe course with long-lasting sequelae of the disease justifies vaccination of a risk population in endemic areas.

Published
2006
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18. Clinical review: Severe malaria.

Author

Trampuz A, Jereb M, Muzlovic I, and Prabhu RM

Subjects
Antimalarials therapeutic use, Blood Transfusion, Critical Care methods, Humans, Severity of Illness Index, Malaria, Falciparum complications, Malaria, Falciparum diagnosis, Malaria, Falciparum pathology, Malaria, Falciparum physiopathology, Malaria, Falciparum therapy
Abstract

Malaria represents a medical emergency because it may rapidly progress to complications and death without prompt and appropriate treatment. Severe malaria is almost exclusively caused by Plasmodium falciparum. The incidence of imported malaria is increasing and the case fatality rate remains high despite progress in intensive care and antimalarial treatment. Clinical deterioration usually appears 3-7 days after onset of fever. Complications involve the nervous, respiratory, renal, and/or hematopoietic systems. Metabolic acidosis and hypoglycemia are common systemic complications. Intravenous quinine and quinidine are the most widely used drugs in the initial treatment of severe falciparum malaria, whereas artemisinin derivatives are currently recommended for quinine-resistant cases. As soon as the patient is clinically stable and able to swallow, oral treatment should be given. The intravascular volume should be maintained at the lowest level sufficient for adequate systemic perfusion to prevent development of acute respiratory distress syndrome. Renal replacement therapy should be initiated early. Exchange blood transfusion has been suggested for the treatment of patients with severe malaria and high parasitemia. For early diagnosis, it is paramount to consider malaria in every febrile patient with a history of travel in an area endemic for malaria.

Published
2003
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19. Routine surface disinfection in health care facilities: should we do it?

Author

Allerberger F, Ayliffe G, Bassetti M, Braveny I, Bucher A, Damani N, Daschner F, Dettenkofer M, Ezpeleta C, Gastmeier P, Geffers C, Giamarellou H, Goldman D, Grzesiowski P, Gubina M, Haanen PE, Haydouchka I, Hübner J, Kalenic S, Van Knippenberg-Gordebeke G, Kranenburg AM, Krcmery V, Kropec A, Krüger W, Lemmen S, Mayhall CG, Meester M, Mehtar S, Munzinger J, Muzlovic I, Ojajarvi J, Rüden H, Scott G, Shah P, Tambic-Andraszevic A, Unertl K, Voss A, and Weist K

Subjects
Risk Factors, Disinfection methods, Hospital Units standards, Infection Control methods
Published
2002
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20. Severe tick-borne encephalitis in Slovenia: epidemiological, clinical and laboratory findings.

Author

Jereb M, Muzlovic I, Avsic-Zupanc T, and Karner P

Subjects
Adolescent, Adult, Aged, Cross-Sectional Studies, Encephalitis, Tick-Borne epidemiology, Encephalitis, Tick-Borne immunology, Female, Humans, Incidence, Leukocyte Count, Male, Middle Aged, Retrospective Studies, Serologic Tests, Slovenia epidemiology, Survival Rate, Antibodies, Viral blood, Encephalitis Viruses, Tick-Borne immunology, Encephalitis, Tick-Borne diagnosis, Immunoglobulin G blood, Immunoglobulin M blood
Abstract

The aim of this retrospective study was to determine epidemiological, clinical and laboratory characteristics in adult patients with the severe form of tick-borne encephalitis. Thirty-one patients with a severe course of disease admitted to the intensive care unit of the Department of Infectious Diseases at the University Medical Centre Ljubljana, Slovenia, between 1996 and 2000 were included in the study. Tick-borne encephalitis virus infection was confirmed by the demonstration of specific IgM and IgG antibodies in serum using routine serological screening tests. All the patients had specific IgM antibodies at admission and IgG antibodies were present in 90.3%. Nineteen patients suffered from severe meningoencephalitis, 11 from meningoencephalomyelitis, and dysfunction of the autonomic nervous system was found in one patient. The mortality rate was 3.3%. Tick bite was recorded in 58% and a characteristic biphasic course of the disease was found in 16 patients. The median cerebrospinal fluid leukocyte count was 112 x 10(6)/l, and in 93.5% of patients the cerebrospinal fluid protein concentration was greater than the cut-off value of 0.45 g/l. The findings of the present study indicate some clinical, epidemiological and laboratory distinctions between published data on the mild or moderately severe form of tick-borne encephalitis and our patients with severe disease.

Published
2002

21. Fatal human herpesvirus 6-associated multifocal meningoencephalitis in an adult female patient.

Author

Beović B, Pecaric-Meglic N, Marin J, Bedernjak J, Muzlovic I, and Cizman M

Subjects
Adult, Brain pathology, Encephalitis, Herpes Simplex drug therapy, Fatal Outcome, Female, Herpesvirus 6, Human pathogenicity, Humans, Magnetic Resonance Imaging, Encephalitis, Herpes Simplex physiopathology, Exanthema Subitum physiopathology, Herpesvirus 6, Human isolation & purification
Abstract

Human herpesvirus 6 (HHV 6) is a known cause of central nervous system infection in immunocompromised patients. Less is known about the clinical course of HHV 6 encephalitis in immunocompetent patients. We report a case of meningoencephalitis in a 42-y-old immunocompetent patient associated with HHV 6 infection.

Published
2001
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