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1. All we know about COVID-19 in pregnancy: from perinatal to ethical and psychological perspective

Author

Spiniello, Lorenzo, Di Mascio, Daniele, Bianco, Cristina, Esposito, Oscar, Giangiordano, Ilaria, Muzii, Ludovico, Giancotti, Antonella, Brunelli, Roberto, and Saccone, Gabriele

Subjects
Pediatrics, RJ1-570, Gynecology and obstetrics, RG1-991
Abstract

The Novel Coronavirus (SARS-CoV-2), also known as Wuhan coronavirus, causes the 2019-nCoV acute respiratory disease or COVID-19. While coronavirus infection is a common and usually self-limiting infection, in a specific population like pregnant women, complications of the disease appear to be more relevant, and pregnant women are particularly susceptible to morbidity and mortality, especially in case of high pathogenicity virus. Most common complications associated with COVID-19 in pregnancy include preterm birth, cesarean delivery, and perinatal deaths. The risk of vertical transmission seems to be negligible.

Published
2020
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8. Sentinel node mapping, sentinel node mapping plus back-up lymphadenectomy, and lymphadenectomy in Early-sTage cERvical caNcer scheduled for fertilItY-sparing approach: The ETERNITY project

Author

Bogani, Giorgio, Scambia, Giovanni, Fagotti, Anna, Fanfani, Francesco, De Vincenzo, Rosa, Ciavattini, Andrea, Sopracordevole, Francesco, Clemente, Nicolò, Del Fabro, Anna, Buttignol, Monica, Cianci, Stefano, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Malzoni, Mario, Falcone, Francesca, Casarin, Jvan, Ghezzi, Fabio, Vizza, Enrico, Berretta, Roberto, Petrillo, Marco, Capobianco, Giampiero, Scarfone, Giovanna, Casaccia, Filippo, Fichera, Mariasole, Leo, Livio, Sozzi, Giulio, Colalillo, Alessio, Cosentino, Francesco, Gardella, Barbara, Serrachioli, Renato, Raimondo, Diego, Chiantera, Vito, Ercoli, Alfredo, Dominoni, Mattia, Zupi, Enrico, Centini, Gabriele, Uccella, Stefano, Franchi, Massimo, Ferrari, Filippo Alberto, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Zanagnolo, Vanna, Schivardi, Gabriella, De Vitis, Luigi Antonio, Cuccu, Ilaria, Ferrari, Federico, Vizzielli, Giuseppe, Restaino, Stefano, Driul, Lorenza, Arcieri, Martina, Sorbi, Flavia, Fambrini, Massimiliano, Aguzzoli, Lorenzo, Mandato, Vincenzo Dario, Murina, Filippo, Solima, Eugenio, Vignali, Michele, Vercellini, Paolo, Ceccaroni, Marcello, Di Donato, Violante, Giannini, Andrea, Muzii, Ludovico, Chiappa, Valentina, Palladino, Simona, Tozzi, Roberto, Cormio, Gennaro, and Raspagliesi, Francesco

Published
2024
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18. How to Manage Endometriosis in Adolescence: The Endometriosis Treatment Italian Club Approach

Author

Lazzeri, Lucia, Andersson, Karin Louise, Angioni, Stefano, Arena, Alessandro, Arena, Saverio, Bartiromo, Ludovica, Berlanda, Nicola, Bonin, Cecilia, Candiani, Massimo, Centini, Gabriele, Forno, Simona Del, Donati, Agnese, Exacoustos, Caterina, Fuggetta, Eliana, Labanca, Luca, Maiorana, Antonio, Maneschi, Francesco, Mattei, Alberto, Muzii, Ludovico, Ottolina, Jessica, Perandini, Alessio, Perelli, Federica, Pino, Ida, Porpora, Maria Grazia, Remorgida, Valentino, Scaramuzzino, Sara, Schimberni, Matteo, Seracchioli, Renato, Solima, Eugenio, Vignali, Michele, Zupi, Errico, and Martire, Francesco Giuseppe

Published
2023
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19. Ten-year outcomes following laparoscopic and open abdominal radical hysterectomy for “low-risk” early-stage cervical cancer: A propensity-score based analysis

Author

Di Donato, Violante, Bogani, Giorgio, Casarin, Jvan, Ghezzi, Fabio, Malzoni, Mario, Falcone, Francesca, Petrillo, Marco, Capobianco, Giampiero, Calò, Filippo, D’Augè, Tullio Golia, Muzii, Ludovico, Benedetti Panici, Pierluigi, Ervas, Elisa, Ditto, Antonino, Raspagliesi, Francesco, Sopracordevole, Francesco, Vizza, Enrico, and Giannini, Andrea

Published
2023
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21. Hysterectomy alone vs. hysterectomy plus sentinel node mapping in endometrial cancer: Perioperative and long-term results from a propensity-score based study

Author

Bogani, Giorgio, Di Donato, Violante, Papadia, Andrea, Buda, Alessandro, Casarin, Jvan, Multinu, Francesco, Plotti, Francesco, Gasparri, Maria Luisa, Pinelli, Ciro, Perrone, Anna Myriam, Ferrero, Simone, Sorbi, Flavia, Landoni, Fabio, Palaia, Innocenza, Perniola, Giorgia, De Iaco, Pierandrea, Cianci, Stefano, Alletti, Salvatore Gueli, Petrillo, Marco, Vizzielli, Giuseppe, Fanfani, Francesco, Angioli, Roberto, Muzii, Ludovico, Ghezzi, Fabio, Vizza, Enrico, Mueller, Michael D., Scambia, Giovanni, Panici, Pierluigi Benedetti, and Raspagliesi, Francesco

Published
2023
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24. Practice patterns and 90-day treatment-related morbidity in early-stage cervical cancer

Author

Bogani, Giorgio, Donato, Violante Di, Scambia, Giovanni, Ghezzi, Fabio, Casarin, Jvan, Landoni, Fabio, Di Martino, Giampaolo, Grassi, Tommaso, Perrone, Anna Myriam, De Iaco, Pierandrea, Multinu, Francesco, Berretta, Roberto, Capozzi, Vito A., Zupi, Errico, Centini, Gabriele, Pellegrino, Antonio, Corso, Silvia, Stevenazzi, Guido, Boschi, Anna Chiara, Comerci, Giuseppe, Greco, Pantaleo, Scutiero, Gennaro, Sopracordevole, Francesco, Giorda, Giorgio, Fichera, Mariasole, Simoncini, Tommaso, Caretto, Marta, Sartori, Enrico, Ferrari, Federico, Cianci, Antonio, Sarpietro, Giuseppe, Matarazzo, Maria Grazia, Giampaolino, Pierluigi, Bifulco, Giuseppe, Morelli, Michele, Dio, Michele Di, Ferrero, Annamaria, Biglia, Nicoletta, Barra, Fabio, Ferrero, Simone, Cianci, Stefano, Chiantera, Vito, Sozzi, Giulio, Ercoli, Alfredo, Schettini, Sergio, Orlando, Teresa, Cannone, Francesco G., Ettore, Giuseppe, Puppo, Andrea, Olearo, Elena, Leone Roberti Maggiore, Umberto, Artuso, Valeria, Palaia, Innocenza, Perniola, Giorgia, Tripodi, Rossana, D'Augè, Tullio Golia, Cuccu, Ilaria, Fischetti, Margherita, Santangelo, Giusi, Casorelli, Assunta, Giannini, Andrea, D’Oria, Ottavia, Vizzielli, Giuseppe, Restaino, Stefano, Bergamini, Alice, Bocciolone, Luca, Plotti, Francesco, Angioli, Roberto, Mantovani, Giulia, Ceccaroni, Marcello, Cassini, Chiara, Dominoni, Mattia, Giambanco, Laura, Amodeo, Silvia, Leo, Livio, Thommaset, Raphaël, Raimondo, Diego, Seracchioli, Renato, Malzoni, Mario, Falcone, Francesca, Gorlero, Franco, Di Luca, Martina, Busato, Enrico, Kilzie, Sami, Dell'Acqua, Andrea, Scarfone, Giovanna, Vercellini, Paolo, Petrillo, Marco, Capobianco, Giampiero, Ciavattini, Andrea, Mereu, Liliana, Scollo, Paolo, Sorbi, Flavia, Fambrini, Massimiliano, Romano, Federico, Ricci, Giuseppe, Trojano, Giuseppe, Damiani, Gianluca Raffaello, Consonni, Roberto, Di Lorenzo, Nadia, Lippolis, Antonio, Tinelli, Raffaele, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Palomba, Stefano, Tripodi, Marcello, Calandra, Davide, Pellegrini, Franco, Zullo, Fulvio, Surico, Daniela, Remorgida, Valentino, Ruscitto, Francesco, Beretta, Paolo, Vizza, Enrico, Muzii, Ludovico, Panici, Pierluigi Benedetti, and Raspagliesi, Francesco

Published
2022
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26. Unexplained infertility and age-related infertility: indistinguishable diagnostic entities but different IVF prognosis.

Author

Mattei, Giulia, Reschini, Marco, Piani, Letizia Li, Fornelli, Gianfranco, Vigano, Paola, Muzii, Ludovico, Vercellini, Paolo, and Somigliana, Edgardo

Subjects
OOCYTE retrieval, OLDER women, AGE distribution, BIRTH rate, RESEARCH grants, INFERTILITY, FERTILIZATION in vitro
Abstract

STUDY QUESTION Is IVF indicated for couples with age-related infertility? SUMMARY ANSWER IVF may be of doubtful utility for age-related infertility. WHAT IS KNOWN ALREADY A diagnosis of unexplained infertility is drawn when the diagnostic work-up fails to identify any patent cause. Although typically managed uniformly, unexplained infertility is likely to comprise a wide range of conditions, including age-related infertility (at least in older women). Unfortunately, no validated tests for the identification of age-related infertility exist and these women are typically treated as unexplained cases. However, homologous ART may be less effective for these women because these techniques may be unable to treat the detrimental effects of ageing on oocyte competence. STUDY DESIGN, SIZE, DURATION Women aged 18–42 years who underwent IVF procedures between January 2014 and December 2021 were selected retrospectively. In the first part of the study, we aimed to assess whether the proportion of women with unexplained infertility (i.e. without patent causes of infertility) increased with age. In the second part of the study, women with unexplained infertility were matched 1:1 by age, study period, and duration of infertility, to those with a patent cause of infertility. If our hypothesis is valid, the first part of the study should highlight an increase in the proportion of unexplained infertility with age. Moreover, in the second part of the study, one should observe a sharper decrease in the rate of IVF success of the procedure with age in women with an unremarkable work-up compared to those with a definite cause of infertility. PARTICIPANTS/MATERIALS, SETTING, METHODS Women were included if: they had been trying to conceive for more than 2 years, they had retrieved more than three oocytes, and had not undergone previous IVF attempts. We exclude couples with severe male factor (criptozoospermia), chronic anovulation, untreated hydrosalpinx, or intracavitary diseases. The first part of the study aimed at investigating the relative proportion of unexplained infertility with age. The outcome of the second part was the distribution of the live births between unexplained versus explained infertility, in women younger or older than 35 years. Only the results of the first IVF cycle were considered (including both fresh and frozen cycles). The live birth rate corresponded to the cumulative chance of a live birth per oocyte retrieval. MAIN RESULTS AND THE ROLE OF CHANCE One thousand five hundred and thirty-five women were selected for the first part of the study; 742 of them had unexplained infertility (48%). The frequency of this diagnosis was lower among women aged <35 years (40%) compared to those ≥35 years (52%) (P  < 0.001). A clear gradient emerged when considering smaller intervals of age (P  < 0.001). A total of 1134 women (567 unexplained cases and 567 explained cases) were selected for the second part of the study. Baseline variables were comparable between women with unexplained and explained infertility. Among women younger than 35 years (n = 229 unexplained cases and 229 explained cases), 108 live births were observed in women with unexplained infertility (47%) and 88 in those with explained infertility (38%). In comparison, among women older than 35 years, the live births occurred in 90 (27%) and 114 (34%) couples, respectively (P  = 0.03). The adjusted odds ratio (OR) for a live birth in older women with unexplained infertility was 0.63 (95% CI: 0.43–0.94). In other words, the effectiveness of IVF in older women with unexplained infertility is reduced by an additional 37% when compared to women of similar age with a patent cause of infertility. Moreover, when considering smaller intervals of age, a gradient of the adverse effect of age on the distribution of live births between unexplained and explained infertility emerged (P  = 0.003). Overall, these results support the hypothesis that IVF may be of modest benefit in women with age-related infertility. The decline in IVF success is sharper in women with unexplained infertility compared to those with explained infertility, indirectly suggesting that IVF cannot effectively treat age-related infertility. LIMITATIONS, REASONS FOR CAUTION We postulated that the greater decline in IVF success with age in the unexplained group could be related to the concomitant increase in the proportion of women with age-related infertility. However, even if this is theoretically logical, the unavailability of validated tools to diagnose age-related infertility makes our inference speculative. We cannot exclude that the prevalence of other unknown causes of infertility that cannot also be effectively overcome with IVF could increase with age. WIDER IMPLICATIONS OF THE FINDINGS Our findings suggest that IVF may be of modest utility for treating age-related infertility. Offering this procedure to older women with an unremarkable infertility work-up may be questioned. However, the diagnosis of age-related infertility remains challenging and identifying a biomarker that could reliably diagnose age-related infertility is a priority. STUDY FUNDING/COMPETING INTEREST(S) The study was partially funded by the Italian Ministry of Health—current research IRCCS and by a specific grant supported by Ferring. ES declares receiving honoraria for lectures at meetings from IBSA and Gedeon-Richter and he also handles private grants of research from Ferring, IBSA, Theramex, and Gedeon-Richter. All the other authors do not have any conflict of interest to declare. TRIAL REGISTRATION NUMBER N/A. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Targeting BRAF pathway in low-grade serous ovarian cancer.

Author

Perrone, Chiara, Angioli, Roberto, Luvero, Daniela, Giannini, Andrea, Di Donato, Violante, Cuccu, Ilaria, Muzii, Ludovico, Raspagliesi, Francesco, and Bogani, Giorgio

Subjects
BRAF genes, OVARIAN cancer, MITOGEN-activated protein kinases, OVERALL survival
Abstract

Mutations in genes encoding for proteins along the RAS-RAF-MEK-ERK pathway have been detected in a variety of tumor entities including ovarian carcinomas. In the recent years, several inhibitors of this pathway have been developed, whose antitumor potential is currently being assessed in different clinical trials. Low grade serous ovarian carcinoma, is a rare gynecological tumor which shows favorable overall survival, compared to the general ovarian cancer population, but worrying resistance to conventional chemotherapies. The clinical behavior of low grade serous ovarian carcinoma reflects the different gene profile compared to high-grade serous carcinoma: KRAS/BRAF mutations. BRAF inhibitors as single agents were approved for the treatment of BRAF mutated tumors. Nevertheless, many patients face progressive disease. The understanding of the mechanisms of resistance to BRAF inhibitors therapy and preclinical studies showing that BRAF and mitogen-activated protein kinase kinase (MEK) inhibitors combined therapy delays the onset of resistance compared to BRAF inhibitor single agent, led to the clinical investigation of combined therapy. The aim of this paper is to review the efficacy and safety of the combination of BRAF plus MEK inhibitors on ovarian carcinomas, in particularly focusing on low grade serous ovarian carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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28. List of contributors

Author

Abramowitz, Matthew C., primary, Alluri, Prasanna, additional, Alyas, Tahira, additional, Arafat, Waleed, additional, Attar, Rukset, additional, Avnioglu, Seda, additional, Barnwal, Ravi Pratap, additional, Bellati, Filippo, additional, Benedetti Panici, Pierluigi, additional, Berardi, Rossana, additional, Bhatia, Alka, additional, Biray Avci, Cigir, additional, Breto, Adrian L., additional, Caruso, Giuseppe, additional, Caserta, Donatella, additional, Ceafalan, Laura C., additional, Cesmeli, Selin, additional, Corcoy, Rosa, additional, Di Bartolomeo, Gabrielle, additional, Di Donato, Violante, additional, Di Micco, Rosa, additional, Escolà-Gil, Joan Carles, additional, Fakhar, Maham, additional, Farmer, Madeline, additional, Farooqi, Ammad Ahmad, additional, Fuste, Victoria, additional, Gallo, Ryan, additional, Gasparri, Maria Luisa, additional, Gentilini, Oreste D., additional, Gherghiceanu, Mihaela, additional, Goel, Sumit, additional, Goker Bagca, Bakiye, additional, Hara, Daiki, additional, Hinescu, Mihail E., additional, Hu, Xiaoyu, additional, Ioghen, Octavian, additional, Iqbal, Muhammad Javed, additional, Jain, Srishti, additional, Julve, Josep, additional, Karasholakova, Lazzat, additional, Kaur, Indu Pal, additional, Khamis, Yomna, additional, Kryvenko, Oleksandr N., additional, Kusoglu, Alican, additional, Lerma, Enrique, additional, Mahmood, Naila Nasir, additional, Malik, Durr-e-shahwar, additional, Malkani, Naila, additional, Martinelli, Chiara, additional, Mato, Eugènia, additional, Mobeen, Iqra, additional, Moral, Antonio, additional, Mumtaz, Sidra, additional, Muzii, Ludovico, additional, Naureen, Humaira, additional, Niculae, Andrei M., additional, Ozbey, Ulku, additional, Paez Espinosa, Enma Veronica, additional, Palaia, Innocenza, additional, Pandit, Chitvan, additional, Papadia, Andrea, additional, Pérez, José Ignacio, additional, Perniola, Giorgia, additional, Pimentel, Tatiana Colombo, additional, Pollack, Alan, additional, Pra, Alan Dal, additional, Punnen, Sanoj, additional, Rashid, Muhammad Usman, additional, Redd, Kristina, additional, Revilla, Giovanna, additional, Rinaldi, Silvia, additional, Roberson, Tinsley, additional, Ruscito, Ilary, additional, Shi, Junwei, additional, Siconolfi, Arianna, additional, Singh, Aagamjit, additional, Singh, Gurpal, additional, Singh, Joga, additional, Smith, Metta, additional, Sohail, Muhammad Imran, additional, Soni, Udit, additional, Spohr, Tania Cristina Leite de Sampaio e, additional, Steed, Kayla Lewis, additional, Stoyanova, Radka, additional, Tanriover, Gamze, additional, Tao, Wensi, additional, Tutar, Yusuf, additional, Yaylim, Ilhan, additional, Yilmaz, Seher, additional, Youssef, Lara, additional, Yulaevna, Ishmuratova Margarita, additional, and Zuber, Veronica, additional

Published
2022
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29. Metastasis in gynecological cancers

Author

Di Donato, Violante, primary, Caruso, Giuseppe, additional, Perniola, Giorgia, additional, Palaia, Innocenza, additional, Muzii, Ludovico, additional, and Benedetti Panici, Pierluigi, additional

Published
2022
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30. Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study

Author

Di Mascio, Daniele, Khalil, Asma, Pilu, Gianluigi, Rizzo, Giuseppe, Caulo, Massimo, Liberati, Marco, Giancotti, Antonella, Lees, Christoph, Volpe, Paolo, Buca, Danilo, Oronzi, Ludovica, D'Amico, Alice, Tinari, Sara, Stampalija, Tamara, Fantasia, Ilaria, Pasquini, Lucia, Masini, Giulia, Brunelli, Roberto, D'Ambrosio, Valentina, Muzii, Ludovico, Manganaro, Lucia, Antonelli, Amanda, Ercolani, Giada, Ciulla, Sandra, Saccone, Gabriele, Maruotti, Giuseppe Maria, Carbone, Luigi, Zullo, Fulvio, Olivieri, Claudiana, Ghi, Tullio, Frusca, Tiziana, Dall'Asta, Andrea, Visentin, Silvia, Cosmi, Erich, Forlani, Francesco, Galindo, Alberto, Villalain, Cecilia, Herraiz, Ignacio, Sileo, Filomena Giulia, Mendez Quintero, Olivia, Salsi, Ginevra, Bracalente, Gabriella, Morales-Roselló, José, Loscalzo, Gabriela, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Parazzini, Cecilia, Lanna, Mariano, Ormitti, Francesca, Toni, Francesco, Murru, Flora, Di Maurizio, Marco, Trincia, Elena, Garcia, Raquel, Bennike Bjørn Petersen, Olav, Neerup, Lisa, Sandager, Puk, Prefumo, Federico, Pinelli, Lorenzo, Mappa, Ilenia, Acuti Martellucci, Cecilia, Flacco, Maria Elena, Manzoli, Lamberto, Giangiordano, Ilaria, Nappi, Luigi, Scambia, Giovanni, Berghella, Vincenzo, and D'Antonio, Francesco

Published
2021
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31. Removal Versus Retention of Cervical Cerclage With Preterm Prelabor Rupture of Membranes: Systematic Review and Meta-analysis

Author

Zullo, Fabrizio, primary, Di Mascio, Daniele, additional, Chauhan, Suneet P., additional, Chrysostomou, Spyridakis, additional, Suff, Natalie, additional, Pecorini, Francesco, additional, D'Ambrosio, Valentina, additional, Sorrenti, Sara, additional, D'Alberti, Elena, additional, Galoppi, Paola, additional, Muzii, Ludovico, additional, Giancotti, Antonella, additional, and Brunelli, Roberto, additional

Published
2024
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33. Factors predicting morbidity in surgically-staged high-risk endometrial cancer patients

Author

Bogani, Giorgio, Papadia, Andrea, Buda, Alessandro, Casarin, Jvan, Di Donato, Violante, Plotti, Francesco, Gasparri, Maria Luisa, Cimmino, Chiara, Pinelli, Ciro, Perrone, Anna Myriam, Barra, Fabio, Cromi, Antonella, Di Martino, Giampaolo, Palaia, Innocenza, Ferrero, Simone, Indini, Alice, De Iaco, Pierandrea, Angioli, Roberto, Luvero, Daniela, Muzii, Ludovico, Ghezzi, Fabio, Landoni, Fabio, Mueller, Michael D., Benedetti Panici, Pierluigi, and Raspagliesi, Francesco

Published
2021
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35. Reply: A paradox? Which paradox?

Author

Somigliana, Edgardo, primary, Chinè, Alessandra, additional, Reschini, Marco, additional, Fornelli, Gianfranco, additional, Basili, Ludovica, additional, Busnelli, Andrea, additional, Viganò, Paola, additional, and Muzii, Ludovico, additional

Published
2024
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37. Uterine serous carcinoma

Author

Bogani, Giorgio, Ray-Coquard, Isabelle, Concin, Nicole, Ngoi, Natalie Y.L., Morice, Philippe, Enomoto, Takayuki, Takehara, Kazuhiro, Denys, Hannelore, Nout, Remi A., Lorusso, Domenica, Vaughan, Michelle M., Bini, Marta, Takano, Masashi, Provencher, Diane, Indini, Alice, Sagae, Satoru, Wimberger, Pauline, Póka, Robert, Segev, Yakir, Kim, Se Ik, Candido dos Reis, Francisco J., Lopez, Salvatore, Mariani, Andrea, Leitao, Mario M., Jr, Raspagliesi, Francesco, Panici, Pieluigi Benedetti, Di Donato, Violante, Muzii, Ludovico, Colombo, Nicoletta, Scambia, Giovanni, Pignata, Sandro, and Monk, Bradley J.

Published
2021
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38. High-risk HPV-positive and -negative high-grade cervical dysplasia: Analysis of 5-year outcomes

Author

Bogani, Giorgio, Sopracordevole, Francesco, Di Donato, Violante, Ciavattini, Andrea, Ghelardi, Alessandro, Lopez, Salvatore, Simoncini, Tommaso, Plotti, Francesco, Casarin, Jvan, Serati, Maurizio, Pinelli, Ciro, Valenti, Gaetano, Bergamini, Alice, Gardella, Barbara, Dell'acqua, Andrea, Monti, Ermelinda, Vercellini, Paolo, Fischetti, Margherita, D'ippolito, Giovanni, Aguzzoli, Lorenzo, Mandato, Vincenzo D., Carunchio, Paola, Carlinfante, Gabriele, Giannella, Luca, Scaffa, Cono, Falcone, Francesca, Borghi, Chiara, Ditto, Antonino, Malzoni, Mario, Giannini, Andrea, Salerno, Maria Giovanna, Liberale, Viola, Contino, Biagio, Donfrancesco, Cristina, Desiato, Michele, Perrone, Anna Myriam, Dondi, Giulia, De Iaco, Pierandrea, Chiappa, Valentina, Ferrero, Simone, Sarpietro, Giuseppe, Matarazzo, Maria G., Cianci, Antonio, Bosio, Sara, Ruisi, Simona, Guerrisi, Rocco, Brusadelli, Claudia, Mosca, Lavinia, Lagana’, Antonio Simone, Tinelli, Raffaele, Signorelli, Mauro, De Vincenzo, Rosa, Zannoni, Gian Franco, Ferrandina, Gabriella, Lovati, Sara, Petrillo, Marco, Dessole, Salvatore, Carlea, Annunziata, Zullo, Fulvio, Angioli, Roberto, Greggi, Stefano, Spinillo, Arsenio, Ghezzi, Fabio, Colacurci, Nicola, Muzii, Ludovico, Benedetti Panici, Pierluigi, Scambia, Giovanni, and Raspagliesi, Francesco

Published
2021
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41. Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study

Author

BOGANI, Giorgio, DI DONATO, Violante, SOPRACORDEVOLE, Francesco, CIAVATTINI, Andrea, GHELARDI, Alessandro, LOPEZ, Salvatore, SIMONCINI, Tommaso, PLOTTI, Francesco, CASARIN, Jvan, SERATI, Maurizio, PINELLI, Ciro, VALENTI, Gaetano, BERGAMINI, Alice, GARDELLA, Barbara, DELL'ACQUA, Andrea, MONTI, Ermelinda, VERCELLINI, Paolo, FISCHETTI, Margherita, D'IPPOLITO, Giovanni, AGUZZOLI, Lorenzo, MANDATO, Vincenzo D., CARUNCHIO, Paola, CARLINFANTE, Gabriele, GIANNELLA, Luca, SCAFFA, Cono, FALCONE, Francesca, BORGHI, Chiara, DITTO, Antonino, MALZONI, Mario, GIANNINI, Andrea, SALERNO, Maria Giovanna, LIBERALE, Viola, CONTINO, Biagio, DONFRANCESCO, Cristina, DESIATO, Michele, PERRONE, Anna Myriam, DONDI, Giulia, De IACO, Pierandrea, LEONE ROBERTI MAGGIORE, Umberto, SIGNORELLI, Mauro, CHIAPPA, Valentina, FERRERO, Simone, SARPIETRO, Giuseppe, MATARAZZO, Maria G., CIANCI, Antonio, BOSIO, Sara, RUISI, Simona, GUERRISI, Rocco, BRUSADELLI, Claudia, MOSCA, Lavinia, TINELLI, Raffaele, DE VINCENZO, Rosa, ZANNONI, Gian Franco, FERRANDINA, Gabriella, PETRILLO, Marco, DESSOLE, Salvatore, ANGIOLI, Roberto, GREGGI, Stefano, SPINILLO, Arsenio, GHEZZI, Fabio, COLACURCI, Nicola, MUZII, Ludovico, BENEDETTI PANICI, Pierluigi, SCAMBIA, Giovanni, and RASPAGLIESI, Francesco

Published
2020
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43. Hormone replacement therapy in gynecological cancer survivors and BRCA mutation carriers: a MITO group survey.

Author

Palaia, Innocenza, Caruso, Giuseppe, Di Donato, Violante, Turetta, Camilla, Savarese, Antonella, Perniola, Giorgia, Gallo, Roberta, Giannini, Andrea, Salutari, Vanda, Bogani, Giorgio, Tomao, Federica, Giannarelli, Diana, Gentile, Gabriella, Musella, Angela, Muzii, Ludovico, and Pignata, Sandro

Subjects
HORMONE therapy, CANCER survivors, MEDICAL personnel, BRCA genes, GYNECOLOGIC care, CANCER treatment
Abstract

Objective: Early iatrogenic menopause in gynecological cancer survivors and BRCA mutation (BRCAm) carriers undergoing risk-reducing salpingo-oophorectomy (RRSO) is a major health concern. Hormone replacement therapy (HRT) is the most effective remedy, but remains underused in clinical practice. The Multicenter Italian Trials in Ovarian cancer and gynecologic malignancies (MITO) group promoted a national survey to investigate the knowledge and attitudes of healthcare professionals regarding the prescription of HRT. Methods: The survey consisted of a self-administered, multiple-choice 45-item questionnaire, available online to all MITO members for 2 months starting from January 2022. Results: A total of 61 participants completed the questionnaire (47 out of 180 MITO centers; compliance: 26.1%). Most respondents were female (73.8%), younger than 50 years (65.6%), and gynecologic oncologists (55.7%), working in public general hospitals (49.2%). An 84.4% of specialists actively discuss HRT with patients and 51.0% of patients ask the specialist for an opinion on HRT. The rate of specialists globally in favor of prescribing HRT was 22.9% for ovarian cancer, 49.1% for cervical cancer, and 8.2% for endometrial cancer patients. Most respondents (70.5%) believe HRT is safe for BRCA-mutated patients after RRSO. Nearly 70% of physicians prescribe systemic HRT, while 23.8% prefer local HRT. Most specialists recommend HRT for as long as there is a benefit and generally for up to 5 years. Conclusion: Real-world data suggest that many healthcare professionals still do not easily prescribe HRT for gynecological cancer survivors and BRCA mutation carriers after RRSO. Further efforts are required to implement the use of HRT in clinical practice and to support both clinicians in recommending HRT and patients in accepting it. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Spotlight on compounded bioidentical hormones

Author

Santangelo, Giusi, primary, Lagana, Antonio Simone, additional, Giannini, Andrea, additional, Murina, Filippo, additional, Di Dio, Camilla, additional, Ruggiero, Gianfilippo, additional, Di Donato, Violante, additional, Perniola, Giorgia, additional, Fischetti, Margherita, additional, Casorelli, Assunta, additional, Clemente, Francesco Francesco, additional, Minnetti, Marianna, additional, Lombardo, Francesco, additional, Panici, Pierluigi Benedetti, additional, Muzii, Ludovico, additional, and Bogani, Giorgio, additional

Published
2023
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48. Robotic vs. laparoscopic approach in obese patients with endometrial cancer: which is the best? A mini-review

Author

Golia D’Augè, Tullio, primary, Cuccu, Ilaria, additional, De Angelis, Emanuele, additional, Buzzaccarini, Giovanni, additional, D’Oria, Ottavia, additional, Besharat, Aris Raad, additional, Caserta, Donatella, additional, Muzii, Ludovico, additional, Bogani, Giorgio, additional, Di Donato, Violante, additional, and Giannini, Andrea, additional

Published
2023
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