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11 results on '"Muzhikyan, Arman"'

2. IgGκ Signal Peptide Enhances the Efficacy of an Influenza Vector Vaccine Against Respiratory Syncytial Virus Infection in Mice

Author

Pulkina, Anastasia Alexandrovna, primary, Vasilyev, Kirill Alexandrovich, additional, Muzhikyan, Arman Artushovich, additional, Sergeeva, Maria, additional, Romanovskaya-Romanko, Ekaterina Andreevna, additional, Shurigina, Anna Polina Sergeevna, additional, Vasin, Andrey Vladimirovich, additional, Stukova, Marina Anatolievna, additional, and Egorov, Andrey, additional

Published
2022
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3. Сomparative analysis of acridineacetate-containing compounds’ radio-sensitizing effect during malignant tumor experimental radiotherapy in a metastatic colorectal cancer model in balb/c mice

Author

Trashkov, Alexander P., primary, Muzhikyan, Arman A., additional, Tsygan, Nikolay V., additional, Ryabtsev, Alexander V., additional, Rybakova, Anna V., additional, Kvanchiani, Varvara V., additional, Kravtsova, Aleftina A., additional, and Vasiliev, Andrei G., additional

Published
2020
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4. Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses

Author

Matyushenko, Victoria, primary, Kotomina, Tatiana, additional, Kudryavtsev, Igor, additional, Mezhenskaya, Daria, additional, Prokopenko, Polina, additional, Matushkina, Anastasia, additional, Sivak, Konstantin, additional, Muzhikyan, Arman, additional, Rudenko, Larisa, additional, and Isakova-Sivak, Irina, additional

Published
2020
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7. Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

Author

Isakova-Sivak, Irina, primary, Matyushenko, Victoria, additional, Kotomina, Tatiana, additional, Kiseleva, Irina, additional, Krutikova, Elena, additional, Donina, Svetlana, additional, Rekstin, Andrey, additional, Larionova, Natalia, additional, Mezhenskaya, Daria, additional, Sivak, Konstantin, additional, Muzhikyan, Arman, additional, Katelnikova, Anastasia, additional, and Rudenko, Larisa, additional

Published
2019
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8. Sequential Immunization with Universal Live Attenuated Influenza Vaccine Candidates Protects Ferrets against a High-Dose Heterologous Virus Challenge

Author

Isakova-Sivak, Irina, primary, Matyushenko, Victoria, additional, Kotomina, Tatiana, additional, Kiseleva, Irina, additional, Krutikova, Elena, additional, Donina, Svetlana, additional, Rekstin, Andrey, additional, Larionova, Natalia, additional, Sivak, Konstantin, additional, Muzhikyan, Arman, additional, Katelnikova, Anastasia, additional, and Rudenko, Larisa, additional

Published
2018
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9. Rationale for vaccination with trivalent or quadrivalent live attenuated influenza vaccines: Protective vaccine efficacy in the ferret model

Author

Rudenko, Larisa, primary, Kiseleva, Irina, additional, Krutikova, Elena, additional, Stepanova, Ekaterina, additional, Rekstin, Andrey, additional, Donina, Svetlana, additional, Pisareva, Maria, additional, Grigorieva, Elena, additional, Kryshen, Kirill, additional, Muzhikyan, Arman, additional, Makarova, Marina, additional, Sparrow, Erin Grace, additional, Torelli, Guido, additional, and Kieny, Marie-Paule, additional

Published
2018
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10. Two Live Attenuated Vaccines against Recent Low–and Highly Pathogenic H7N9 Influenza Viruses Are Safe and Immunogenic in Ferrets

Author

Rudenko, Larisa, primary, Kiseleva, Irina, additional, Krutikova, Elena, additional, Stepanova, Ekaterina, additional, Isakova-Sivak, Irina, additional, Donina, Svetlana, additional, Rekstin, Andrey, additional, Pisareva, Maria, additional, Bazhenova, Ekaterina, additional, Kotomina, Tatiana, additional, Katelnikova, Anastasia, additional, Muzhikyan, Arman, additional, Makarov, Valery, additional, Sparrow, Erin, additional, and Torelli, Guido, additional

Published
2018
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11. Two Live Attenuated Vaccines against Recent Low⁻and Highly Pathogenic H7N9 Influenza Viruses Are Safe and Immunogenic in Ferrets.

Author

Rudenko L, Kiseleva I, Krutikova E, Stepanova E, Isakova-Sivak I, Donina S, Rekstin A, Pisareva M, Bazhenova E, Kotomina T, Katelnikova A, Muzhikyan A, Makarov V, Sparrow EG, and Torelli G

Abstract

Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïve. To be better prepared for the potential occurrence of an H7N9 pandemic, in 2017 the World Health Organization recommended developing candidate vaccine viruses from two new H7N9 viruses, A/Guangdong/17SF003/2016 (A/GD) and A/Hong Kong/125/2017 (A/HK). This report describes the development of live attenuated influenza vaccine (LAIV) candidates against A/GD and A/HK viruses and study of their safety and immunogenicity in the ferret model in order to choose the most promising one for a phase I clinical trial. The A/HK-based vaccine candidate (A/17/HK) was developed by classical reassortment in eggs. The A/GD-based vaccine candidate (A/17/GD) was generated by reverse genetics. Ferrets were vaccinated with two doses of LAIV or phosphate-buffered saline. Both H7N9 LAIVs tested were safe for ferrets, as shown by absence of clinical signs, and by virological and histological data; they were immunogenic after a single vaccination. These results provide a compelling argument for further testing of these vaccines in volunteers. Since the A/HK virus represents the cluster that has caused the majority of human cases, and because the A/HK-based LAIV candidate was developed by classical reassortment, this is the preferred candidate for a phase I clinical trial.

Published
2018
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