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20 results on '"Mutter, Jurik A."'

1. Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling

Author

Alig, Stefan K., Shahrokh Esfahani, Mohammad, Garofalo, Andrea, Li, Michael Yu, Rossi, Cédric, Flerlage, Tim, Flerlage, Jamie E., Adams, Ragini, Binkley, Michael S., Shukla, Navika, Jin, Michael C., Olsen, Mari, Telenius, Adèle, Mutter, Jurik A., Schroers-Martin, Joseph G., Sworder, Brian J., Rai, Shinya, King, Daniel A., Schultz, Andre, Bögeholz, Jan, Su, Shengqin, Kathuria, Karan R., Liu, Chih Long, Kang, Xiaoman, Strohband, Maya J., Langfitt, Deanna, Pobre-Piza, Kristine Faye, Surman, Sherri, Tian, Feng, Spina, Valeria, Tousseyn, Thomas, Buedts, Lieselot, Hoppe, Richard, Natkunam, Yasodha, Fornecker, Luc-Matthieu, Castellino, Sharon M., Advani, Ranjana, Rossi, Davide, Lynch, Ryan, Ghesquières, Hervé, Casasnovas, Olivier, Kurtz, David M., Marks, Lianna J., Link, Michael P., André, Marc, Vandenberghe, Peter, Steidl, Christian, Diehn, Maximilian, and Alizadeh, Ash A.

Published
2024
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3. Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling

Author

Alig, Stefan K., primary, Esfahani, Mohammad Shahrokh, additional, Garofalo, Andrea, additional, Li, Michael Yu, additional, Rossi, Cédric, additional, Flerlage, Tim, additional, Flerlage, Jamie E., additional, Adams, Ragini, additional, Binkley, Michael S., additional, Shukla, Navika, additional, Jin, Michael C., additional, Olsen, Mari, additional, Telenius, Adèle, additional, Mutter, Jurik A., additional, Schroers-Martin, Joseph G., additional, Sworder, Brian J., additional, Rai, Shinya, additional, King, Daniel A., additional, Schultz, Andre, additional, Bögeholz, Jan, additional, Su, Shengqin, additional, Kathuria, Karan R., additional, Liu, Chih Long, additional, Kang, Xiaoman, additional, Strohband, Maya J., additional, Langfitt, Deanna, additional, Pobre-Piza, Kristine Faye, additional, Surman, Sherri, additional, Tian, Feng, additional, Spina, Valeria, additional, Tousseyn, Thomas, additional, Buedts, Lieselot, additional, Hoppe, Richard, additional, Natkunam, Yasodha, additional, Fornecker, Luc-Matthieu, additional, Castellino, Sharon M., additional, Advani, Ranjana, additional, Rossi, Davide, additional, Lynch, Ryan, additional, Ghesquières, Hervé, additional, Casasnovas, Olivier, additional, Kurtz, David M., additional, Marks, Lianna J., additional, Link, Michael P., additional, André, Marc, additional, Vandenberghe, Peter, additional, Steidl, Christian, additional, Diehn, Maximilian, additional, and Alizadeh, Ash A., additional

Published
2023
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4. Expression of Irf3 and Irf7 in tumour cells drives pancreatic cancer development and progression

Author

Fahr, Lisa, primary, Benitz, Simone, additional, Straub, Tobias, additional, Mutter, Jurik, additional, Lisiecki, Hannah, additional, Mahajan, Ujjwal M., additional, Beyer, Georg, additional, Steiger, Katja, additional, Terrasi, Andrea, additional, Schotta, Gunnar, additional, Imhof, Axel, additional, Lauber, Kirsten, additional, Kleeff, Jörg, additional, Michalski, Christoph W., additional, Mayerle, Julia, additional, and Regel, Ivonne, additional

Published
2023
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5. Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas

Author

Lauer, Eliza M, primary, Riegler, Ella, additional, Mutter, Jurik A, additional, Alig, Stefan K, additional, Bleul, Sabine, additional, Kuehn, Julia, additional, Ranganathan, Lavanya, additional, Klingler, Christian, additional, Demerath, Theo, additional, Würtemberger, Urs, additional, Rau, Alexander, additional, Weiß, Jakob, additional, Eisenblaetter, Michel, additional, Bamberg, Fabian, additional, Prinz, Marco, additional, Finke, Jürgen, additional, Duyster, Justus, additional, Illerhaus, Gerald, additional, Diehn, Maximilian, additional, Alizadeh, Ash A, additional, Schorb, Elisabeth, additional, Reinacher, Peter C, additional, and Scherer, Florian, additional

Published
2023
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6. Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas.

Author

Lauer, Eliza M, Riegler, Ella, Mutter, Jurik A, Alig, Stefan K, Bleul, Sabine, Kuehn, Julia, Ranganathan, Lavanya, Klingler, Christian, Demerath, Theo, Würtemberger, Urs, Rau, Alexander, Weiß, Jakob, Eisenblaetter, Michel, Bamberg, Fabian, Prinz, Marco, Finke, Jürgen, Duyster, Justus, Illerhaus, Gerald, Diehn, Maximilian, and Alizadeh, Ash A

Published
2024
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7. Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas

Author

Mutter, Jurik A., primary, Alig, Stefan K., additional, Esfahani, Mohammad S., additional, Lauer, Eliza M., additional, Mitschke, Jan, additional, Kurtz, David M., additional, Kühn, Julia, additional, Bleul, Sabine, additional, Olsen, Mari, additional, Liu, Chih Long, additional, Jin, Michael C., additional, Macaulay, Charles W., additional, Neidert, Nicolas, additional, Volk, Timo, additional, Eisenblaetter, Michel, additional, Rauer, Sebastian, additional, Heiland, Dieter H., additional, Finke, Jürgen, additional, Duyster, Justus, additional, Wehrle, Julius, additional, Prinz, Marco, additional, Illerhaus, Gerald, additional, Reinacher, Peter C., additional, Schorb, Elisabeth, additional, Diehn, Maximilian, additional, Alizadeh, Ash A., additional, and Scherer, Florian, additional

Published
2022
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8. Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas.

Author

Mutter, Jurik A., Alig, Stefan K., Esfahani, Mohammad S., Lauer, Eliza M., Mitschke, Jan, Kurtz, David M., Kühn, Julia, Bleul, Sabine, Olsen, Mari, Liu, Chih Long, Jin, Michael C., Macaulay, Charles W., Neidert, Nicolas, Volk, Timo, Eisenblaetter, Michel, Rauer, Sebastian, Heiland, Dieter H., Finke, Jürgen, Duyster, Justus, and Wehrle, Julius

Published
2023
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9. Profiling of Circulating Tumor DNA for Noninvasive Disease Detection, Risk Stratification, and MRD Monitoring in Patients with CNS Lymphoma

Author

Mutter, Jurik Andreas, primary, Alig, Stefan, additional, Lauer, Eliza Maria, additional, Esfahani, Mohammad Shahrokh, additional, Mitschke, Jan, additional, Kurtz, David M., additional, Kühn, Julia, additional, Bleul, Sabine, additional, Olsen, Mari, additional, Liu, Chih Long, additional, Jin, Michael C., additional, Macaulay, Charles, additional, Neidert, Nicolas Noel, additional, Volk, Timo, additional, Rauer, Sebastian, additional, Heiland, Dieter Henrik, additional, Finke, Jürgen, additional, Duyster, Justus, additional, Wehrle, Julius, additional, Prinz, Marco, additional, Illerhaus, Gerald, additional, Reinacher, Peter C., additional, Schorb, Elisabeth, additional, Diehn, Maximilian, additional, Alizadeh, Ash A., additional, and Scherer, Florian, additional

Published
2021
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10. Early assessment of circulating tumor DNA after curative‐intent resection predicts tumor recurrence in early‐stage and locally advanced non‐small‐cell lung cancer

Author

Waldeck, Silvia, primary, Mitschke, Jan, additional, Wiesemann, Sebastian, additional, Rassner, Michael, additional, Andrieux, Geoffroy, additional, Deuter, Max, additional, Mutter, Jurik, additional, Lüchtenborg, Anne‐Marie, additional, Kottmann, Daniel, additional, Titze, Laurin, additional, Zeisel, Christoph, additional, Jolic, Martina, additional, Philipp, Ulrike, additional, Lassmann, Silke, additional, Bronsert, Peter, additional, Greil, Christine, additional, Rawluk, Justyna, additional, Becker, Heiko, additional, Isbell, Lisa, additional, Müller, Alexandra, additional, Doostkam, Soroush, additional, Passlick, Bernward, additional, Börries, Melanie, additional, Duyster, Justus, additional, Wehrle, Julius, additional, Scherer, Florian, additional, and von Bubnoff, Nikolas, additional

Published
2021
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13. Genomic, Transcriptional, and Immunological Validation of Distinct Molecular Subtypes of Classic Hodgkin Lymphoma through Tissue-Based and Noninvasive Methods

Author

Alig, Stefan K., Shahrokh Esfahani, Mohammad, Garofalo, Andrea, Li, Michael Yu, Rossi, Cédric, Flerlage, Timothy, Flerlage, Jamie E., Adams, Ragini, Binkley, Michael S., Shukla, Navika, Jin, Michael, Olsen, Mari, Telenius, Adele, Mutter, Jurik A, Schroers-Martin, Joseph, Sworder, Brian J., Rai, Shinya, King, Daniel, Schultz, Andre, Bögeholz, Jan Lukas, Su, Shengqin, Kathuria, Karan R, Liu, Chih Long, Kang, Xiaoman, Langfitt, Deanna M., Pobre-Piza, Kristine Faye, Tian, Feng, Strohband, Maya J., Spina, Valeria, Tousseyn, Thomas, Buedts, Lieselot, Fornecker, Luc-Matthieu, Castellino, Sharon M., Advani, Ranjana H., Rossi, Davide, Lynch, Ryan C, Ghesquieres, Herve, Casasnovas, Olivier, Kurtz, David M., Marks, Lianna J., Link, Michael P., Andre, Marc, Vandenberghe, Peter, Steidl, Christian, Diehn, Maximilian, and Alizadeh, Ash A.

Published
2023
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14. Ibrutinib in patients with relapsed/refractory central nervous system lymphoma: A retrospective single-centre analysis

Author

Lauer, Eliza M., Waterhouse, Miguel, Braig, Moritz, Mutter, Jurik, Bleul, Sabine, Duque-Afonso, Jesús, Duyster, Justus, Marks, Reinhard, Reinacher, Peter Christoph, Prinz, Marco, Illerhaus, Gerald, Finke, Jürgen, Schorb, Elisabeth, Scherer, Florian, and Publica

Subjects
real-world analysis, relapsed / refractory disease, Ibrutinib, BTK inhibition, central nervous system lymphoma
Published
2020

15. Ibrutinib in patients with relapsed/refractory central nervous system lymphoma: A retrospective single‐centre analysis

Author

Lauer, Eliza M., primary, Waterhouse, Miguel, additional, Braig, Moritz, additional, Mutter, Jurik, additional, Bleul, Sabine, additional, Duque‐Afonso, Jesús, additional, Duyster, Justus, additional, Marks, Reinhard, additional, Reinacher, Peter C., additional, Prinz, Marco, additional, Illerhaus, Gerald, additional, Finke, Jürgen, additional, Schorb, Elisabeth, additional, and Scherer, Florian, additional

Published
2020
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16. Early assessment of circulating tumor DNA after curative‐intent resection predicts tumor recurrence in early‐stage and locally advanced non‐small‐cell lung cancer.

Author

Waldeck, Silvia, Mitschke, Jan, Wiesemann, Sebastian, Rassner, Michael, Andrieux, Geoffroy, Deuter, Max, Mutter, Jurik, Lüchtenborg, Anne‐Marie, Kottmann, Daniel, Titze, Laurin, Zeisel, Christoph, Jolic, Martina, Philipp, Ulrike, Lassmann, Silke, Bronsert, Peter, Greil, Christine, Rawluk, Justyna, Becker, Heiko, Isbell, Lisa, and Müller, Alexandra

Abstract

Circulating tumor DNA (ctDNA) has demonstrated great potential as a noninvasive biomarker to assess minimal residual disease (MRD) and profile tumor genotypes in patients with non‐small‐cell lung cancer (NSCLC). However, little is known about its dynamics during and after tumor resection, or its potential for predicting clinical outcomes. Here, we applied a targeted‐capture high‐throughput sequencing approach to profile ctDNA at various disease milestones and assessed its predictive value in patients with early‐stage and locally advanced NSCLC. We prospectively enrolled 33 consecutive patients with stage IA to IIIB NSCLC undergoing curative‐intent tumor resection (median follow‐up: 26.2 months). From 21 patients, we serially collected 96 plasma samples before surgery, during surgery, 1–2 weeks postsurgery, and during follow‐up. Deep next‐generation sequencing using unique molecular identifiers was performed to identify and quantify tumor‐specific mutations in ctDNA. Twelve patients (57%) had detectable mutations in ctDNA before tumor resection. Both ctDNA detection rates and ctDNA concentrations were significantly higher in plasma obtained during surgery compared with presurgical specimens (57% versus 19% ctDNA detection rate, and 12.47 versus 6.64 ng·mL−1, respectively). Four patients (19%) remained ctDNA‐positive at 1–2 weeks after surgery, with all of them (100%) experiencing disease progression at later time points. In contrast, only 4 out of 12 ctDNA‐negative patients (33%) after surgery experienced relapse during follow‐up. Positive ctDNA in early postoperative plasma samples was associated with shorter progression‐free survival (P = 0.013) and overall survival (P = 0.004). Our findings suggest that, in early‐stage and locally advanced NSCLC, intraoperative plasma sampling results in high ctDNA detection rates and that ctDNA positivity early after resection identifies patients at risk for relapse. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Ring1b-mediated epigenetic silencing of acinar cell fate genes is a mandatory event in pancreatic carcinogenesis

Author

Benitz, Simone, primary, Straub, Tobias, additional, Mahajan, Ujjwal Mukund, additional, Mutter, Jurik, additional, Czemmel, Stefan, additional, Unruh, Tatjana, additional, Fahr, Lisa, additional, Wingerath, Britta, additional, Deubler, Sabrina, additional, Cheng, Tao, additional, Nahnsen, Sven, additional, Bruns, Philipp, additional, Kong, Bo, additional, Raulefs, Susanne, additional, Ceyhan, Güralp, additional, Mayerle, Julia, additional, Steiger, Katja, additional, Esposito, Irene, additional, Kleeff, Jörg, additional, Michalski, Christoph W., additional, and Regel, Ivonne, additional

Published
2019
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19. Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis

Author

Benitz, Simone, primary, Straub, Tobias, additional, Mahajan, Ujjwal Mukund, additional, Mutter, Jurik, additional, Czemmel, Stefan, additional, Unruh, Tatjana, additional, Wingerath, Britta, additional, Deubler, Sabrina, additional, Fahr, Lisa, additional, Cheng, Tao, additional, Nahnsen, Sven, additional, Bruns, Philipp, additional, Kong, Bo, additional, Raulefs, Susanne, additional, Ceyhan, Güralp O, additional, Mayerle, Julia, additional, Steiger, Katja, additional, Esposito, Irene, additional, Kleeff, Jörg, additional, Michalski, Christoph W, additional, and Regel, Ivonne, additional

Published
2019
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20. Inferred Gene Expression By Cell-Free DNA Profiling Allows Noninvasive Lymphoma Classification

Author

Mutter, Jurik A, Shahrokh Esfahani, Mohammad, Schroers-Martin, Joseph, Alig, Stefan K., Hamilton, Mark P., Sworder, Brian J., Tessoulin, Benoit, Boegeholz, Jan, Flerlage, Timothy, Flerlage, Jamie E., Binkley, Michael S., Sugio, Takeshi, Rossi, Cédric, Olsen, Mari, Liu, Chih Long, Le Gouill, Steven, Kurtz, David M., Diehn, Maximilian, and Alizadeh, Ash A.

Abstract

Background:Current diagnostic criteria for mature B-cell tumors require a combination of histopathological, immunophenotypic, cytogenetic, and genetic evaluations on tissue biopsy specimens (Campo, Blood2022; Alaggio, Leuk2022). Despite this battery of techniques, substantial heterogeneity remains in specific subgroups that can be further resolved using additional molecular diagnostic methods, including gene expression profiling (GEP). For example, among aggressive B-cell tumors, a subset recognized as high-grade B-cell lymphomas can be identified as harboring MYC+BCL2 lesions by FISH (HGBCL-DH-BCL2). However, a significant remaining high-risk subset also have a characteristic tumor gene expression “double-hit signature” or “dark zone signature” (DZsig) (Ennishi, JCO2018; Alduaij, Blood2023).

Published
2023
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