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5. List of Contributors

Author

Abbatecola, Angela Marie, primary, Abe, Koji, additional, Abisambra, Jose F., additional, Ahmad, Aliya, additional, Alaei, Hojjatollah, additional, Alagiakrishnan, Kannayiram, additional, Aliev, Gjumrakch, additional, Allegri, Ricardo Francisco, additional, Almeida, Osvaldo P., additional, Álvarez-Cervera, Fernando J., additional, Alwi, Nor Amalina Ahmad, additional, Ames, David, additional, Anderson-Mooney, Amelia Jane, additional, Andrade, José Paulo, additional, Anglés, Neus, additional, Armstrong, R.A., additional, Assunção, Marco, additional, Atteia, Hebatallah Husseini, additional, Avila, Marco Fidel, additional, Bair, Ming-Jong, additional, Barbagallo, Mario, additional, Barberger-Gateau, Pascale, additional, Barbieri, Michelangela, additional, Barreto, George E., additional, Bata-García, José L., additional, Begum, Monirun, additional, Bellia, Francesco, additional, Belvedere, Mario, additional, Bennett, Louise E., additional, Białecka, Monika, additional, Bird, Michael, additional, Blundo, Carlo, additional, Boccardi, Virginia, additional, Bolea, Irene, additional, Bosco, Domenico, additional, Brouwer-Brolsma, Elske M., additional, Brust, John C.M., additional, Buffa, Roberto, additional, Bunner, Kendra D., additional, Burri, Lena, additional, Cabezas, Ricardo, additional, Camina, María Alicia, additional, Campbell, Tessa N., additional, Cano, Lourdes Rexach, additional, Chen, Huan-Lin, additional, Chen, Jianmin, additional, Cheung, David Wing-Shing, additional, Choy, Francis Y.M., additional, Chua, J., additional, Colica, Carmen, additional, Corcia, Philippe, additional, Craft, Suzanne, additional, Cristiano, Dario, additional, Cusimano, Michael D., additional, Dalton, Kate, additional, Davidson, Terry L., additional, De Bartolo, Matteo, additional, de Bem, Andreza Fabro, additional, de Castro, Isac, additional, de Groot, Lisette C.P.G.M., additional, de la Cruz Marcos, Sandra, additional, de Oliveira, Jade, additional, del Balzo, Valeria, additional, Deguchi, Kentaro, additional, Deguchi, Shoko, additional, Deth, Richard, additional, Dominguez, Ligia J., additional, Donini, Lorenzo M., additional, Doruk, Huseyin, additional, Dziewas, Rainer, additional, Díes, Rafael Carles, additional, El-Bachá, Ramon Santos, additional, El-Swefy, Sahar Elsayed, additional, Enciso, Laura Carreño, additional, Ermio, Caterina, additional, Escribano, Begoña M., additional, Estrada-Sánchez, Ana María, additional, Etgen, Thorleif, additional, Farina, Marcelo, additional, Fava, Antonietta, additional, Feart, Catherine, additional, Feng, Lei, additional, Fernández-Fernández, Laura, additional, Ferreira, Danilio Alvear Sampaio, additional, Fiala, Milan, additional, Fialdini, Renata Caruso, additional, Fisher, Cheryl, additional, Galimberti, Daniela, additional, Galvin, James E., additional, Gelber, Rebecca P., additional, Gerace, Carmela, additional, Giannakopoulos, Panteleimon, additional, Giannopoulos, Phillip F., additional, Giridharan, Vijayasree V., additional, Giusti, Anna Maria, additional, Gonzalez, Janneth, additional, Góngora-Alfaro, José L., additional, Gordon, Paul H., additional, Greiwe, Jeffrey S., additional, Grima, Natalie A., additional, Guedes, Rubem, additional, Gupta, Susham, additional, Gyengesi, Erika, additional, Haller, Sven, additional, Hanson, Angela J., additional, Harvey, Jenni, additional, Hassan, Ossama Morsi, additional, Henderson, Samuel T., additional, Herrup, Karl, additional, Hickey, M.A., additional, Hoerr, Robert, additional, Hou, Xiaoli, additional, Huang, Chengyu, additional, Hügel, Helmut M., additional, Hwang, Sam-Long, additional, Ikeda, Yoshio, additional, Irie, Kazuhiro, additional, Jack, Alexandria, additional, Jackson, Neale, additional, Jackson, Richard L., additional, Jannise, Brittany, additional, Jiang, Yugang, additional, Johnson, C.Shanthi, additional, Jolliff, James S., additional, Jové, Mariona, additional, Kam, Jonathan S., additional, Kanoski, Scott E., additional, Khan, Khurshid, additional, Kimura, Takemi, additional, Kitagishi, Yasuko, additional, Konishi, Tetsuya, additional, Kovacs, Gabor G., additional, Krause, Debra, additional, Kua, Ee-Heok, additional, Kurata, Tomoko, additional, Kurian, Mini, additional, Kwok, Timothy, additional, Lam, Wai Ping, additional, Lattanzio, Fabrizia, additional, Lawrence, Catherine B., additional, Lee, Tih-Shih, additional, Lee, Yuan-Kai, additional, Leslie, Paula, additional, Leung, Ping Chung, additional, Li, Runping, additional, Liang, Willmann, additional, Lim, Siong-Meng, additional, Lin, Fengwu, additional, Lin, I-Tsung, additional, Loef, Martin, additional, Lovblad, Karl-Olof, additional, Luque, Evelio, additional, Luz, Protásio Lemos da, additional, Macaulay, S.Lance, additional, Madan, Swati, additional, Maetzler, Walter, additional, Mahendran, R., additional, Majeed, Abu Bakar Abdul, additional, Mander, Alastair G., additional, Mani, Vasudevan, additional, Manley, Graham, additional, Manor, Danny, additional, Margetts, Christine, additional, Marini, Elisabetta, additional, Martin-Fernandez, J.Javier, additional, Martínez-Martos, José Manuel, additional, Martínez, Irene Villegas, additional, de Mateo Silleras, Beatriz, additional, Matsuda, Satoru, additional, May, Brian H., additional, McGirr, Alexander, additional, McCormick, Laurie M., additional, Mehta, Jatin, additional, Mereu, Elena, additional, Messina, Antonino, additional, Minami, Akari, additional, Mirowsky, John, additional, Moore, Eileen M., additional, Moreira, Eduardo Luiz Gasnhar, additional, Morelló, José Ramón, additional, Mori, Takashi, additional, Münch, Gerald, additional, Murakami, Kazuma, additional, Mutter, Joachim, additional, Naharci, Mehmet Ilkin, additional, Nakao, Frank Shigeo, additional, Ng, Tze-Pin, additional, Nigro, Julie, additional, Ninomiya, Toshiharu, additional, Nishiyama, Marcelo, additional, Nomani, Erum, additional, Nooyens, Astrid C.J., additional, Oda, Adriana Leico, additional, Okamura, Hitoshi, additional, Oliveira, Acary Souza Bulle, additional, Ono, Yuna, additional, Orsitto, Giuseppe, additional, Ozawa, Mio, additional, Pallet, Véronique, additional, Pamplona, Reinald, additional, Paolisso, Giuseppe, additional, Paradiso, Sergio, additional, Pase, Matthew P., additional, Patki, Gaurav, additional, Piguet, Olivier, additional, Pinto, Alessandro, additional, Pirritano, Domenico, additional, Plastino, Massimiliano, additional, Poggiogalle, Eleonora, additional, Polidori, M.Cristina, additional, Polimanti, Renato, additional, Portero-Otin, Manuel, additional, Power, Brian D., additional, Praticò, Domenico, additional, Prediger, Rui Daniel S., additional, Preedy, Victor R., additional, Prendergast, Mark A., additional, Rae, Daniela, additional, Ramasamy, Kalavathy, additional, Ramli, Muhammad Zaki, additional, Ramirez, Bartolomé, additional, Ramírez-Expósito, María Jesús, additional, Rebec, George V., additional, Reddy, V.Prakash, additional, Redondo del Río, María Paz, additional, Reguant, Jordi, additional, Reisi, Parham, additional, Remington, Ruth, additional, Ricci, Monica, additional, Rizzarelli, Enrico, additional, Robinson, Stephen R., additional, Rogers, Eugene, additional, Rosini, Francesca, additional, Roupas, Peter, additional, Rufa, Alessandra, additional, Russo, María Julieta, additional, Sahathevan, Ramesh, additional, Salim, Samina, additional, Salvioni, Cristina Cleide dos Santos, additional, Sample, Camille H., additional, Santamaría, Abel, additional, Saqqur, Maher, additional, Saragat, Bruno, additional, Sauvant, Julie, additional, Sauvant, Patrick, additional, Scarpini, Elio, additional, Scelza, M.F.Z., additional, Schwen, Richard J., additional, Self, Rachel L., additional, Serrano, José C.E., additional, Shea, Thomas B., additional, Shih, Ping-Hsiao, additional, Shimizu, Takahiko, additional, Shunichiro, Shinagawa, additional, Siahmard, Zahra, additional, Sławek, Jarosław, additional, Smoliner, Christine, additional, Solé, Montse, additional, Sprini, Delia, additional, Squitti, Rosanna, additional, Srulijes, Karin, additional, Stahl, Wilhelm, additional, Stanich, Patricia, additional, Stephens, Brian R., additional, Sun, Mingxue, additional, Takamatsu, Junichi, additional, Tang, Hong Chai, additional, Thandavarayan, Rajarajan A., additional, Torrente, Daniel, additional, Town, Terrence, additional, Túnez, Isaac, additional, Ulatowski, Lynn, additional, Unzeta, Mercedes, additional, Valente, Tony, additional, van Keizerswaard, Jolanda, additional, van de Rest, Ondine, additional, van der Zwaluw, Nikita L., additional, Vecchio, Graziella, additional, Veiga, Judith Jimenez, additional, Vila-Rodriguez, Fidel, additional, Walach, Harald, additional, Warnecke, Tobias, additional, Watters, David A.K., additional, Weber, Wolfgang, additional, Weitzman, Rachel, additional, White, Lon R., additional, Wirth, Rainer, additional, Wu, Chia-Hsien, additional, Xiao, Kai, additional, Xue, Charlie C.L., additional, Yen, Gow-Chin, additional, Yew, David Tai-Wai, additional, Yokoi, Teruo, additional, Zhang, Anthony L., additional, Zhang, Lihong, additional, and Zito, Giancarlo, additional

Published
2015
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14. Is dental amalgam safe for humans? The opinion of the scientific committee of the European Commission

Author

Mutter Joachim

Subjects
Industrial medicine. Industrial hygiene, RC963-969
Abstract

Abstract It was claimed by the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR)) in a report to the EU-Commission that "....no risks of adverse systemic effects exist and the current use of dental amalgam does not pose a risk of systemic disease..." [1, available from: http://ec.europa.eu/health/ph_risk/committees/04_scenihr/docs/scenihr_o_016.pdf]. SCENIHR disregarded the toxicology of mercury and did not include most important scientific studies in their review. But the real scientific data show that: (a) Dental amalgam is by far the main source of human total mercury body burden. This is proven by autopsy studies which found 2-12 times more mercury in body tissues of individuals with dental amalgam. Autopsy studies are the most valuable and most important studies for examining the amalgam-caused mercury body burden. (b) These autopsy studies have shown consistently that many individuals with amalgam have toxic levels of mercury in their brains or kidneys. (c) There is no correlation between mercury levels in blood or urine, and the levels in body tissues or the severity of clinical symptoms. SCENIHR only relied on levels in urine or blood. (d) The half-life of mercury in the brain can last from several years to decades, thus mercury accumulates over time of amalgam exposure in body tissues to toxic levels. However, SCENIHR state that the half-life of mercury in the body is only "20-90 days". (e) Mercury vapor is about ten times more toxic than lead on human neurons and with synergistic toxicity to other metals. (f) Most studies cited by SCENIHR which conclude that amalgam fillings are safe have severe methodical flaws.

Published
2011
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15. Metals and Parkinson's Disease : Mechanisms and Biochemical Processes

Author

Bjorklund, Geir, Stejskal, Vera, Urbina, Mauricio A., Dadar, Maryam, Chirumbolo, Salvatore, Mutter, Joachim, Bjorklund, Geir, Stejskal, Vera, Urbina, Mauricio A., Dadar, Maryam, Chirumbolo, Salvatore, and Mutter, Joachim

Abstract

Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease (PD), while the remaining cases are of unknown etiology. It is believed that environmental factors may be involved in the causality of a large proportion of PD cases. Several PD genes are activated by xenobiotic exposure, and a link between pesticide exposure and PD has been demonstrated. Many epidemiological studies have shown an association between PD and exposure to metals such as mercury, lead, manganese, copper, iron, aluminum, bismuth, thallium, and zinc. This review explores the biological effects, the pathogenetic processes, genetic susceptibilities to metals as well as examining future strategies for PD treatment, such as chelation therapy.

Published
2018
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25. Xenobiotikaausleitung bei einer Patientin mit Fibromyalgie, chronischer Erschöpfung und stammbetonter Adipositas.

Author

Mutter, Joachim, Naumann, Johannes, and Guethlin, Corina

Abstract

Der Fall einer 28-jährigen Patientin wird geschildert, die seit mehr als 5 Jahren an ausgeprägter Erschöpfung, Weichteilschmerzen, Obstipation, Stammfettsucht, abdominellen Striae, Ödemen, Tinnitus sowie Follikulitis und Schwellung des Gesichtes litt. Es konnte eine isolierte sekundäre Nebenniereninsuffizienz festgestellt werden. Es fanden sich Hinweise für eine umweltmedizinische Genese der Beschwerden. Es wurde eine umfassende Therapie, die Ernährungsberatung, Ausleitung, Nahrungsergänzungen und Akupunktur beinhaltete, durchgeführt. Unter dieser kam es zu einer vollständigen Heilung der Erkrankung. Ein derartiger Fall wurde bisher in der Literatur noch nicht beschrieben. Der Fall, der schulmedizinische Befund sowie die möglichen pathogenetischen Mechanismen werden aus komplementärmedizinischer Sicht ausführlich und praxisnah dargestellt. [ABSTRACT FROM AUTHOR]

Published
2007
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27. Elimination of xenobiotics in a female patient with fibromyalgia, chronic fatigue, and trunk obesity.

Author

Mutter J, Naumann J, and Guethlin C

Subjects
Adult, Complementary Therapies, Dietary Supplements, Fatigue Syndrome, Chronic diet therapy, Female, Fibromyalgia diet therapy, Humans, Obesity diet therapy, Treatment Outcome, Acupuncture Therapy methods, Chelating Agents therapeutic use, Fatigue Syndrome, Chronic therapy, Fibromyalgia therapy, Obesity therapy
Abstract

We describe the case of a 28-year-old woman, who had been suffering for more than 5 years from severe fatigue, myofascial pain, obstipation, obesity of trunk, abdominal striae, oedema, tinnitus, folliculitis, and facial swelling. The patient also showed a secondary adrenocortical insufficiency. From the anamnesis we assumed that environmental factors could account for the symptoms. The therapy consisted of dietary advise, chelating agents, supplements, and acupuncture. Under this therapy the patient became completely symptom-free. No such case has ever been reported before. We report mainly on the CAM diagnostic and therapeutic procedures, which are discussed together with the assumed pathogenetic factors.

Published
2007
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28. Mercury and autism: accelerating evidence?

Author

Mutter J, Naumann J, Schneider R, Walach H, and Haley B

Subjects
Autistic Disorder drug therapy, Autistic Disorder epidemiology, Autoimmune Diseases chemically induced, Autoimmune Diseases pathology, Chelating Agents therapeutic use, Child, Humans, Inflammation chemically induced, Inflammation pathology, Mercury analysis, Mercury metabolism, Mercury Poisoning metabolism, Autistic Disorder chemically induced, Mercury toxicity, Mercury Poisoning epidemiology
Abstract

The causes of autism and neurodevelopmental disorders are unknown. Genetic and environmental risk factors seem to be involved. Because of an observed increase in autism in the last decades, which parallels cumulative mercury exposure, it was proposed that autism may be in part caused by mercury. We review the evidence for this proposal. Several epidemiological studies failed to find a correlation between mercury exposure through thimerosal, a preservative used in vaccines, and the risk of autism. Recently, it was found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Repetitive doses of thimerosal leads to neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequently, autistic children have significantly decreased level of reduced glutathione. Promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites.

Published
2005

29. Alzheimer disease: mercury as pathogenetic factor and apolipoprotein E as a moderator.

Author

Mutter J, Naumann J, Sadaghiani C, Schneider R, and Walach H

Subjects
Aged, Alzheimer Disease genetics, Alzheimer Disease pathology, Animals, Apolipoprotein E2, Apolipoprotein E4, Cell Death drug effects, Chromosomes, Human, Pair 19 genetics, Dental Amalgam chemistry, Genetic Predisposition to Disease, Humans, Middle Aged, Neurofibrillary Tangles pathology, Neurons pathology, Rats, Alzheimer Disease etiology, Apolipoproteins E genetics, Dental Amalgam adverse effects, Mercury adverse effects, Neurons drug effects
Abstract

The etiology of most cases of Alzheimer's disease (AD) is as yet unknown. Epidemiological studies suggest that environmental factors may be involved beside genetic risk factors. Some studies have shown higher mercury concentrations in brains of deceased and in blood of living patients with Alzheimer's disease. Experimental studies have found that even smallest amounts of mercury but no other metals in low concentrations were able to cause all nerve cell changes, which are typical for Alzheimer's disease. The most important genetic risk factor for sporadic Alzheimer's disease is the presence of the apolipoprotein Ee4 allele whereas the apolipoprotein Ee2 allele reduces the risk of developing Alzheimer's disease. Some investigators have suggested that apolipoprotein Ee4 has a reduced ability to bind metals like mercury and therefore explain the higher risk for Alzheimer's disease. Therapeutic approaches embrace pharmaceuticals which bind metals in the brain of patients with Alzheimer's disease. In sum, both the findings from epidemiological and demographical studies, the frequency of amalgam application in industrialized countries, clinical studies, experimental studies and the dental state of AD patients in comparison to controls suggest a decisive role for inorganic mercury in the etiology of AD.

Published
2004

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